

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.97008445 |
| 2 | cullin deneddylation (GO:0010388) | 5.11265535 |
| 3 | protein deneddylation (GO:0000338) | 5.01976960 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 4.83126062 |
| 5 | water-soluble vitamin biosynthetic process (GO:0042364) | 4.73164924 |
| 6 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.56706513 |
| 7 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.41289710 |
| 8 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.40792539 |
| 9 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.40770411 |
| 10 | protein complex biogenesis (GO:0070271) | 4.36327404 |
| 11 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.27447364 |
| 12 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.25112491 |
| 13 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.16319662 |
| 14 | ATP synthesis coupled proton transport (GO:0015986) | 4.16319662 |
| 15 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.15999251 |
| 16 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.15999251 |
| 17 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.15649628 |
| 18 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.15649628 |
| 19 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.15649628 |
| 20 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.12876997 |
| 21 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.10079523 |
| 22 | NADH dehydrogenase complex assembly (GO:0010257) | 4.10079523 |
| 23 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.10079523 |
| 24 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.05044824 |
| 25 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.02091119 |
| 26 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.01422814 |
| 27 | negative regulation of ligase activity (GO:0051352) | 4.01422814 |
| 28 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.00177948 |
| 29 | rRNA modification (GO:0000154) | 3.98008608 |
| 30 | DNA deamination (GO:0045006) | 3.97663025 |
| 31 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.96001272 |
| 32 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.96001272 |
| 33 | protein K6-linked ubiquitination (GO:0085020) | 3.92727754 |
| 34 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.91210877 |
| 35 | protein neddylation (GO:0045116) | 3.68449340 |
| 36 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.67485088 |
| 37 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.53944672 |
| 38 | positive regulation of ligase activity (GO:0051351) | 3.53322753 |
| 39 | GTP biosynthetic process (GO:0006183) | 3.51898874 |
| 40 | rRNA methylation (GO:0031167) | 3.50459465 |
| 41 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.50317325 |
| 42 | cytokine biosynthetic process (GO:0042089) | 3.49958691 |
| 43 | respiratory chain complex IV assembly (GO:0008535) | 3.46378916 |
| 44 | respiratory electron transport chain (GO:0022904) | 3.45486728 |
| 45 | regulation of chronic inflammatory response (GO:0002676) | 3.44179293 |
| 46 | signal peptide processing (GO:0006465) | 3.42617062 |
| 47 | electron transport chain (GO:0022900) | 3.42136090 |
| 48 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.29636462 |
| 49 | cytochrome complex assembly (GO:0017004) | 3.28433482 |
| 50 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.28372083 |
| 51 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.28303065 |
| 52 | positive regulation of cell cycle arrest (GO:0071158) | 3.21959002 |
| 53 | CENP-A containing nucleosome assembly (GO:0034080) | 3.20787818 |
| 54 | chromatin remodeling at centromere (GO:0031055) | 3.17821238 |
| 55 | regulation of cellular amine metabolic process (GO:0033238) | 3.09810107 |
| 56 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.07427371 |
| 57 | establishment of integrated proviral latency (GO:0075713) | 3.05923873 |
| 58 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.04204299 |
| 59 | IMP biosynthetic process (GO:0006188) | 3.03448650 |
| 60 | postreplication repair (GO:0006301) | 3.01887867 |
| 61 | amino acid activation (GO:0043038) | 3.01047558 |
| 62 | tRNA aminoacylation (GO:0043039) | 3.01047558 |
| 63 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.00114819 |
| 64 | intracellular protein transmembrane import (GO:0044743) | 2.97276412 |
| 65 | tRNA aminoacylation for protein translation (GO:0006418) | 2.96444998 |
| 66 | regulation of ligase activity (GO:0051340) | 2.95116744 |
| 67 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.90118400 |
| 68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.90118400 |
| 69 | protein-cofactor linkage (GO:0018065) | 2.88350623 |
| 70 | UTP biosynthetic process (GO:0006228) | 2.87356885 |
| 71 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.84564621 |
| 72 | regulation of mitochondrial translation (GO:0070129) | 2.83647477 |
| 73 | guanosine-containing compound biosynthetic process (GO:1901070) | 2.82533474 |
| 74 | mitochondrial RNA metabolic process (GO:0000959) | 2.81813605 |
| 75 | replication fork processing (GO:0031297) | 2.81405357 |
| 76 | tRNA metabolic process (GO:0006399) | 2.80993748 |
| 77 | recombinational repair (GO:0000725) | 2.80588564 |
| 78 | protein targeting to mitochondrion (GO:0006626) | 2.80204426 |
| 79 | DNA strand elongation (GO:0022616) | 2.80131818 |
| 80 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.78933052 |
| 81 | cytokine metabolic process (GO:0042107) | 2.78782662 |
| 82 | pseudouridine synthesis (GO:0001522) | 2.78614133 |
| 83 | righting reflex (GO:0060013) | 2.78493561 |
| 84 | histone exchange (GO:0043486) | 2.78351922 |
| 85 | double-strand break repair via homologous recombination (GO:0000724) | 2.77662893 |
| 86 | cell wall macromolecule catabolic process (GO:0016998) | 2.75189337 |
| 87 | telomere maintenance via telomere lengthening (GO:0010833) | 2.74295857 |
| 88 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.74001023 |
| 89 | tRNA processing (GO:0008033) | 2.73060838 |
| 90 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.72170209 |
| 91 | negative regulation of protein ubiquitination (GO:0031397) | 2.72125488 |
| 92 | piRNA metabolic process (GO:0034587) | 2.69084425 |
| 93 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.67275133 |
| 94 | signal transduction in response to DNA damage (GO:0042770) | 2.66450248 |
| 95 | inner mitochondrial membrane organization (GO:0007007) | 2.66102143 |
| 96 | nonmotile primary cilium assembly (GO:0035058) | 2.65209468 |
| 97 | protein K11-linked ubiquitination (GO:0070979) | 2.64782863 |
| 98 | regulation of cell cycle arrest (GO:0071156) | 2.64691865 |
| 99 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.62379655 |
| 100 | cell cycle G1/S phase transition (GO:0044843) | 2.62379655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.18894498 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.55422492 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.03897195 |
| 4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.89172223 |
| 5 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.67049530 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.29339295 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.14124834 |
| 8 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.98544385 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.82806914 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.81930203 |
| 11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.81586464 |
| 12 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.64995702 |
| 13 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.59534771 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.58846375 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.57439734 |
| 16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.38096802 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.36831048 |
| 18 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.34609643 |
| 19 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.29693185 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28028593 |
| 21 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.16264369 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.12546685 |
| 23 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.02734373 |
| 24 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.02062212 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.98409648 |
| 26 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.88113374 |
| 27 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.87948348 |
| 28 | EWS_26573619_Chip-Seq_HEK293_Human | 1.77738858 |
| 29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.76526314 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.72537278 |
| 31 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.71705598 |
| 32 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.71379166 |
| 33 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.69116702 |
| 34 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.67734971 |
| 35 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.62980163 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.61196754 |
| 37 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.53909695 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.52417491 |
| 39 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.51888105 |
| 40 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50830404 |
| 41 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.49701079 |
| 42 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.46114351 |
| 43 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.45426247 |
| 44 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.44921410 |
| 45 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.42469087 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.41454034 |
| 47 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41229506 |
| 48 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.36228757 |
| 49 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.34065570 |
| 50 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.33072281 |
| 51 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.32607573 |
| 52 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.32030650 |
| 53 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.30654552 |
| 54 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.30381911 |
| 55 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.29867561 |
| 56 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.28879022 |
| 57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.24265789 |
| 58 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.22850587 |
| 59 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.22180190 |
| 60 | P300_19829295_ChIP-Seq_ESCs_Human | 1.21224417 |
| 61 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.16913672 |
| 62 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.16063927 |
| 63 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.15815362 |
| 64 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.15793699 |
| 65 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.14819484 |
| 66 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.14290925 |
| 67 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.12614020 |
| 68 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.11447524 |
| 69 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.11282194 |
| 70 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.06167682 |
| 71 | NCOR_22424771_ChIP-Seq_293T_Human | 1.05823383 |
| 72 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.05275571 |
| 73 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.01874759 |
| 74 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.01874759 |
| 75 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.99915708 |
| 76 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.99468022 |
| 77 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.99131714 |
| 78 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.97989453 |
| 79 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.97803872 |
| 80 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.96996803 |
| 81 | AR_20517297_ChIP-Seq_VCAP_Human | 0.96770416 |
| 82 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.95599606 |
| 83 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.93582839 |
| 84 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.93556061 |
| 85 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.93556061 |
| 86 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.92875866 |
| 87 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.91168780 |
| 88 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.90738800 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88642592 |
| 90 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.87455033 |
| 91 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.86787513 |
| 92 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.86037773 |
| 93 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.85099227 |
| 94 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.84919961 |
| 95 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.84537354 |
| 96 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.84064432 |
| 97 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.83797650 |
| 98 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.83789639 |
| 99 | GATA3_26560356_Chip-Seq_TH2_Human | 0.82752954 |
| 100 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.81695290 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.81082304 |
| 2 | MP0002736_abnormal_nociception_after | 3.69601488 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 3.69516960 |
| 4 | MP0010094_abnormal_chromosome_stability | 2.95848962 |
| 5 | MP0003646_muscle_fatigue | 2.95774091 |
| 6 | MP0008057_abnormal_DNA_replication | 2.85059455 |
| 7 | MP0000372_irregular_coat_pigmentation | 2.82226041 |
| 8 | MP0001968_abnormal_touch/_nociception | 2.74992552 |
| 9 | MP0002837_dystrophic_cardiac_calcinosis | 2.50859835 |
| 10 | MP0003786_premature_aging | 2.49925646 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.42267831 |
| 12 | MP0005408_hypopigmentation | 2.27096975 |
| 13 | MP0003693_abnormal_embryo_hatching | 2.12086490 |
| 14 | MP0008875_abnormal_xenobiotic_pharmacok | 2.06155388 |
| 15 | MP0003186_abnormal_redox_activity | 1.91767046 |
| 16 | MP0003718_maternal_effect | 1.87361054 |
| 17 | MP0002102_abnormal_ear_morphology | 1.86326511 |
| 18 | MP0006035_abnormal_mitochondrial_morpho | 1.83396196 |
| 19 | MP0003880_abnormal_central_pattern | 1.78829160 |
| 20 | MP0008872_abnormal_physiological_respon | 1.78180629 |
| 21 | MP0005075_abnormal_melanosome_morpholog | 1.77976934 |
| 22 | MP0001501_abnormal_sleep_pattern | 1.74453109 |
| 23 | MP0004142_abnormal_muscle_tone | 1.74105987 |
| 24 | MP0006072_abnormal_retinal_apoptosis | 1.73625780 |
| 25 | MP0003111_abnormal_nucleus_morphology | 1.67233323 |
| 26 | MP0001986_abnormal_taste_sensitivity | 1.62490992 |
| 27 | MP0005551_abnormal_eye_electrophysiolog | 1.59748677 |
| 28 | MP0003077_abnormal_cell_cycle | 1.57046556 |
| 29 | MP0004957_abnormal_blastocyst_morpholog | 1.55978032 |
| 30 | MP0000685_abnormal_immune_system | 1.47663005 |
| 31 | MP0004147_increased_porphyrin_level | 1.46094178 |
| 32 | MP0005171_absent_coat_pigmentation | 1.42194963 |
| 33 | MP0003136_yellow_coat_color | 1.40427188 |
| 34 | MP0001835_abnormal_antigen_presentation | 1.40346285 |
| 35 | MP0009046_muscle_twitch | 1.38688819 |
| 36 | MP0003195_calcinosis | 1.31282069 |
| 37 | MP0002095_abnormal_skin_pigmentation | 1.30517040 |
| 38 | MP0004885_abnormal_endolymph | 1.26945930 |
| 39 | MP0001529_abnormal_vocalization | 1.26500696 |
| 40 | MP0005253_abnormal_eye_physiology | 1.26056405 |
| 41 | MP0010386_abnormal_urinary_bladder | 1.25526434 |
| 42 | MP0005165_increased_susceptibility_to | 1.25302027 |
| 43 | MP0005671_abnormal_response_to | 1.25233625 |
| 44 | MP0002006_tumorigenesis | 1.23757595 |
| 45 | MP0001873_stomach_inflammation | 1.23499867 |
| 46 | MP0008877_abnormal_DNA_methylation | 1.20954081 |
| 47 | MP0002272_abnormal_nervous_system | 1.20091490 |
| 48 | MP0002938_white_spotting | 1.18546394 |
| 49 | MP0000358_abnormal_cell_content/ | 1.17874979 |
| 50 | MP0001984_abnormal_olfaction | 1.10859320 |
| 51 | MP0001905_abnormal_dopamine_level | 1.10181665 |
| 52 | MP0008007_abnormal_cellular_replicative | 1.09677124 |
| 53 | MP0001764_abnormal_homeostasis | 1.08778901 |
| 54 | MP0008775_abnormal_heart_ventricle | 1.07866686 |
| 55 | MP0002733_abnormal_thermal_nociception | 1.07563252 |
| 56 | MP0009333_abnormal_splenocyte_physiolog | 1.07227541 |
| 57 | MP0000427_abnormal_hair_cycle | 1.05211836 |
| 58 | MP0004742_abnormal_vestibular_system | 1.04345153 |
| 59 | MP0004215_abnormal_myocardial_fiber | 1.03859678 |
| 60 | MP0001486_abnormal_startle_reflex | 1.03757901 |
| 61 | MP0008932_abnormal_embryonic_tissue | 1.02165821 |
| 62 | MP0002138_abnormal_hepatobiliary_system | 1.01060840 |
| 63 | MP0002148_abnormal_hypersensitivity_rea | 0.99192825 |
| 64 | MP0003119_abnormal_digestive_system | 0.98916751 |
| 65 | MP0005670_abnormal_white_adipose | 0.98309725 |
| 66 | MP0005646_abnormal_pituitary_gland | 0.97633185 |
| 67 | MP0004145_abnormal_muscle_electrophysio | 0.97133701 |
| 68 | MP0001970_abnormal_pain_threshold | 0.96377128 |
| 69 | MP0002210_abnormal_sex_determination | 0.96089054 |
| 70 | MP0009764_decreased_sensitivity_to | 0.96018583 |
| 71 | MP0005084_abnormal_gallbladder_morpholo | 0.92982381 |
| 72 | MP0005379_endocrine/exocrine_gland_phen | 0.92127241 |
| 73 | MP0001485_abnormal_pinna_reflex | 0.90054108 |
| 74 | MP0005410_abnormal_fertilization | 0.88130049 |
| 75 | MP0001929_abnormal_gametogenesis | 0.87680082 |
| 76 | MP0002751_abnormal_autonomic_nervous | 0.87624741 |
| 77 | MP0005423_abnormal_somatic_nervous | 0.83562974 |
| 78 | MP0009745_abnormal_behavioral_response | 0.83030111 |
| 79 | MP0005389_reproductive_system_phenotype | 0.81593929 |
| 80 | MP0004782_abnormal_surfactant_physiolog | 0.81139535 |
| 81 | MP0005645_abnormal_hypothalamus_physiol | 0.79516860 |
| 82 | MP0001756_abnormal_urination | 0.79325134 |
| 83 | MP0006276_abnormal_autonomic_nervous | 0.77252243 |
| 84 | MP0000653_abnormal_sex_gland | 0.76096377 |
| 85 | MP0005085_abnormal_gallbladder_physiolo | 0.75971934 |
| 86 | MP0005636_abnormal_mineral_homeostasis | 0.75171457 |
| 87 | MP0001963_abnormal_hearing_physiology | 0.74850173 |
| 88 | MP0002166_altered_tumor_susceptibility | 0.73949220 |
| 89 | MP0009785_altered_susceptibility_to | 0.73847873 |
| 90 | MP0005365_abnormal_bile_salt | 0.73631640 |
| 91 | MP0004019_abnormal_vitamin_homeostasis | 0.73525382 |
| 92 | MP0001145_abnormal_male_reproductive | 0.72839350 |
| 93 | MP0005266_abnormal_metabolism | 0.72309145 |
| 94 | MP0001853_heart_inflammation | 0.72295617 |
| 95 | MP0005174_abnormal_tail_pigmentation | 0.70310173 |
| 96 | MP0002067_abnormal_sensory_capabilities | 0.69797870 |
| 97 | MP0002160_abnormal_reproductive_system | 0.67496612 |
| 98 | MP0002090_abnormal_vision | 0.66517601 |
| 99 | MP0004043_abnormal_pH_regulation | 0.63166523 |
| 100 | MP0001119_abnormal_female_reproductive | 0.62784462 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.57764002 |
| 2 | Acute encephalopathy (HP:0006846) | 4.86498700 |
| 3 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.83039680 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.70676517 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.67692885 |
| 6 | Increased CSF lactate (HP:0002490) | 4.57842363 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.03805156 |
| 8 | Cerebral edema (HP:0002181) | 3.66251899 |
| 9 | Abnormality of the labia minora (HP:0012880) | 3.64510339 |
| 10 | Hepatic necrosis (HP:0002605) | 3.62952631 |
| 11 | Congenital sensorineural hearing impairment (HP:0008527) | 3.43358861 |
| 12 | Increased hepatocellular lipid droplets (HP:0006565) | 3.31233553 |
| 13 | Increased serum lactate (HP:0002151) | 3.13460151 |
| 14 | Congenital, generalized hypertrichosis (HP:0004540) | 3.12891030 |
| 15 | Lipid accumulation in hepatocytes (HP:0006561) | 2.93940027 |
| 16 | Renal Fanconi syndrome (HP:0001994) | 2.84738258 |
| 17 | Lactic acidosis (HP:0003128) | 2.76004018 |
| 18 | Respiratory failure (HP:0002878) | 2.75106619 |
| 19 | Optic disc pallor (HP:0000543) | 2.69080477 |
| 20 | Pancreatic cysts (HP:0001737) | 2.67652847 |
| 21 | Leukodystrophy (HP:0002415) | 2.61574035 |
| 22 | Increased serum pyruvate (HP:0003542) | 2.61458239 |
| 23 | Exertional dyspnea (HP:0002875) | 2.60511257 |
| 24 | Meckel diverticulum (HP:0002245) | 2.58210196 |
| 25 | Abnormality of glycolysis (HP:0004366) | 2.56738296 |
| 26 | Degeneration of anterior horn cells (HP:0002398) | 2.54860119 |
| 27 | Abnormality of the anterior horn cell (HP:0006802) | 2.54860119 |
| 28 | Abolished electroretinogram (ERG) (HP:0000550) | 2.51164405 |
| 29 | Exercise intolerance (HP:0003546) | 2.50835002 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.42865839 |
| 31 | Pancreatic fibrosis (HP:0100732) | 2.40252498 |
| 32 | Lethargy (HP:0001254) | 2.37214157 |
| 33 | Congenital stationary night blindness (HP:0007642) | 2.29439539 |
| 34 | Medial flaring of the eyebrow (HP:0010747) | 2.27580898 |
| 35 | CNS demyelination (HP:0007305) | 2.26639343 |
| 36 | Abnormality of midbrain morphology (HP:0002418) | 2.26161099 |
| 37 | Molar tooth sign on MRI (HP:0002419) | 2.26161099 |
| 38 | Abnormality of chromosome stability (HP:0003220) | 2.24072200 |
| 39 | 3-Methylglutaconic aciduria (HP:0003535) | 2.22697303 |
| 40 | Increased intramyocellular lipid droplets (HP:0012240) | 2.22521919 |
| 41 | Abnormality of the prostate (HP:0008775) | 2.21024379 |
| 42 | Prostate neoplasm (HP:0100787) | 2.20828550 |
| 43 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.19409751 |
| 44 | True hermaphroditism (HP:0010459) | 2.18784477 |
| 45 | Supernumerary spleens (HP:0009799) | 2.14870149 |
| 46 | Methylmalonic acidemia (HP:0002912) | 2.08257164 |
| 47 | Cutaneous melanoma (HP:0012056) | 2.05807271 |
| 48 | Opisthotonus (HP:0002179) | 2.04441135 |
| 49 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.04049894 |
| 50 | Adrenal hypoplasia (HP:0000835) | 2.03902329 |
| 51 | Abnormality of the preputium (HP:0100587) | 2.03867485 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.03687660 |
| 53 | Methylmalonic aciduria (HP:0012120) | 2.02974666 |
| 54 | Progressive microcephaly (HP:0000253) | 2.00285423 |
| 55 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.00049307 |
| 56 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.96530916 |
| 57 | Abnormality of alanine metabolism (HP:0010916) | 1.96530916 |
| 58 | Hyperalaninemia (HP:0003348) | 1.96530916 |
| 59 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.95797521 |
| 60 | Abnormality of urine glucose concentration (HP:0011016) | 1.93888716 |
| 61 | Glycosuria (HP:0003076) | 1.93888716 |
| 62 | Palpitations (HP:0001962) | 1.93493785 |
| 63 | Neoplasm of the adrenal gland (HP:0100631) | 1.93391859 |
| 64 | Hypoplasia of the fovea (HP:0007750) | 1.92306726 |
| 65 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.92306726 |
| 66 | Pendular nystagmus (HP:0012043) | 1.87558722 |
| 67 | Delayed CNS myelination (HP:0002188) | 1.86765411 |
| 68 | Retinal dysplasia (HP:0007973) | 1.84309210 |
| 69 | Abnormality of methionine metabolism (HP:0010901) | 1.82799033 |
| 70 | IgG deficiency (HP:0004315) | 1.80914650 |
| 71 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.80726200 |
| 72 | Clubbing of toes (HP:0100760) | 1.80155625 |
| 73 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.80048528 |
| 74 | Abnormal protein glycosylation (HP:0012346) | 1.79070856 |
| 75 | Abnormal glycosylation (HP:0012345) | 1.79070856 |
| 76 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.79070856 |
| 77 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.79070856 |
| 78 | Chromsome breakage (HP:0040012) | 1.78966486 |
| 79 | Colon cancer (HP:0003003) | 1.78787327 |
| 80 | Patchy hypopigmentation of hair (HP:0011365) | 1.78520840 |
| 81 | Blindness (HP:0000618) | 1.77552394 |
| 82 | Congenital primary aphakia (HP:0007707) | 1.75828808 |
| 83 | Absent/shortened dynein arms (HP:0200106) | 1.74127461 |
| 84 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.74127461 |
| 85 | Hypoproteinemia (HP:0003075) | 1.72984307 |
| 86 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.71230164 |
| 87 | Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) | 1.70485713 |
| 88 | Short 1st metacarpal (HP:0010034) | 1.70485713 |
| 89 | Sclerocornea (HP:0000647) | 1.70331046 |
| 90 | Abnormal spermatogenesis (HP:0008669) | 1.69861906 |
| 91 | Abnormality of renal resorption (HP:0011038) | 1.68803424 |
| 92 | Cerebral hypomyelination (HP:0006808) | 1.68495594 |
| 93 | Constricted visual fields (HP:0001133) | 1.67531072 |
| 94 | Gait imbalance (HP:0002141) | 1.67010903 |
| 95 | Increased muscle lipid content (HP:0009058) | 1.66524453 |
| 96 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.64483365 |
| 97 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.64483365 |
| 98 | Gaze-evoked nystagmus (HP:0000640) | 1.62939518 |
| 99 | Emotional lability (HP:0000712) | 1.62913209 |
| 100 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.62905547 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.08939871 |
| 2 | EIF2AK1 | 3.60403112 |
| 3 | STK16 | 3.47291608 |
| 4 | FRK | 3.27232466 |
| 5 | EIF2AK3 | 2.96913088 |
| 6 | PDK2 | 2.87150756 |
| 7 | BMPR1B | 2.56421029 |
| 8 | TSSK6 | 2.55973000 |
| 9 | SRPK1 | 2.53851038 |
| 10 | TRIM28 | 2.29932592 |
| 11 | NUAK1 | 2.17742704 |
| 12 | NEK1 | 2.14282888 |
| 13 | BUB1 | 2.00063575 |
| 14 | MST4 | 1.97918447 |
| 15 | PBK | 1.93319012 |
| 16 | VRK1 | 1.89007236 |
| 17 | MAP3K12 | 1.85165803 |
| 18 | PLK3 | 1.81640251 |
| 19 | PLK4 | 1.73573221 |
| 20 | CCNB1 | 1.67307620 |
| 21 | TLK1 | 1.52635470 |
| 22 | ZAK | 1.52358410 |
| 23 | NME1 | 1.48499264 |
| 24 | CSNK1G3 | 1.45760176 |
| 25 | GRK1 | 1.43419987 |
| 26 | MKNK2 | 1.41085662 |
| 27 | PLK2 | 1.37342761 |
| 28 | EPHA4 | 1.32894625 |
| 29 | NME2 | 1.31070135 |
| 30 | CSNK1A1L | 1.27965349 |
| 31 | OXSR1 | 1.26949586 |
| 32 | TAOK3 | 1.24143160 |
| 33 | PHKG1 | 1.22044469 |
| 34 | PHKG2 | 1.22044469 |
| 35 | CSNK1G2 | 1.17498688 |
| 36 | DAPK1 | 1.17467327 |
| 37 | MKNK1 | 1.17073016 |
| 38 | TIE1 | 1.13714896 |
| 39 | CSNK1G1 | 1.13381930 |
| 40 | CDK19 | 1.07606175 |
| 41 | MAPK13 | 1.06328329 |
| 42 | STK39 | 1.04098906 |
| 43 | PLK1 | 1.02701815 |
| 44 | ADRBK2 | 1.02658937 |
| 45 | ACVR1B | 1.01939878 |
| 46 | WNK4 | 0.92555827 |
| 47 | CDC7 | 0.92457696 |
| 48 | EIF2AK2 | 0.87358708 |
| 49 | TTK | 0.86755269 |
| 50 | STK38L | 0.85656707 |
| 51 | MYLK | 0.78650840 |
| 52 | BCKDK | 0.76688265 |
| 53 | LIMK1 | 0.75359765 |
| 54 | ERBB3 | 0.71837551 |
| 55 | KDR | 0.71638293 |
| 56 | CAMK2D | 0.71290830 |
| 57 | LMTK2 | 0.69491618 |
| 58 | MAP4K2 | 0.68624204 |
| 59 | ATR | 0.65103068 |
| 60 | TEC | 0.65100423 |
| 61 | PAK3 | 0.62540775 |
| 62 | GRK5 | 0.60721973 |
| 63 | ALK | 0.60534872 |
| 64 | BCR | 0.59909352 |
| 65 | TNIK | 0.59010619 |
| 66 | NEK6 | 0.58067616 |
| 67 | WNK3 | 0.57612720 |
| 68 | ADRBK1 | 0.56583865 |
| 69 | PTK2B | 0.55925164 |
| 70 | TXK | 0.55361593 |
| 71 | WEE1 | 0.53080301 |
| 72 | INSRR | 0.52924336 |
| 73 | RPS6KB2 | 0.51530574 |
| 74 | MAPKAPK3 | 0.51314018 |
| 75 | ILK | 0.50706546 |
| 76 | TAF1 | 0.49250229 |
| 77 | AURKB | 0.48728296 |
| 78 | CAMKK2 | 0.47912911 |
| 79 | CAMK2A | 0.47030471 |
| 80 | PASK | 0.46692093 |
| 81 | CSNK2A1 | 0.43764303 |
| 82 | ERBB4 | 0.42845276 |
| 83 | PRKCI | 0.41934380 |
| 84 | PAK4 | 0.40947008 |
| 85 | CAMK2G | 0.39782386 |
| 86 | AURKA | 0.39651602 |
| 87 | TGFBR1 | 0.39536749 |
| 88 | PRKCE | 0.39020475 |
| 89 | IKBKB | 0.38976562 |
| 90 | STK10 | 0.37877791 |
| 91 | PINK1 | 0.36993260 |
| 92 | MAPKAPK5 | 0.36739783 |
| 93 | BMPR2 | 0.35363793 |
| 94 | DAPK3 | 0.34048146 |
| 95 | CSNK2A2 | 0.32853193 |
| 96 | ATM | 0.31483601 |
| 97 | CSNK1A1 | 0.31397379 |
| 98 | PKN1 | 0.30722896 |
| 99 | CHEK2 | 0.30635282 |
| 100 | CAMK2B | 0.28998142 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.48439719 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.12252326 |
| 3 | Homologous recombination_Homo sapiens_hsa03440 | 2.77994775 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 2.62698415 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.60756280 |
| 6 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.55957937 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.48947493 |
| 8 | Mismatch repair_Homo sapiens_hsa03430 | 2.40576960 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.32187321 |
| 10 | Asthma_Homo sapiens_hsa05310 | 2.07771353 |
| 11 | RNA polymerase_Homo sapiens_hsa03020 | 2.06625864 |
| 12 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.94707690 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.87356059 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 1.81602143 |
| 15 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.77916813 |
| 16 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.73665480 |
| 17 | Base excision repair_Homo sapiens_hsa03410 | 1.71716538 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.70077623 |
| 19 | Ribosome_Homo sapiens_hsa03010 | 1.67356281 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.50091075 |
| 21 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.48551208 |
| 22 | Allograft rejection_Homo sapiens_hsa05330 | 1.47944879 |
| 23 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.46852343 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.45717305 |
| 25 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.40967461 |
| 26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.38253608 |
| 27 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.35011831 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.31054474 |
| 29 | Basal transcription factors_Homo sapiens_hsa03022 | 1.29734436 |
| 30 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.29039770 |
| 31 | Spliceosome_Homo sapiens_hsa03040 | 1.27489724 |
| 32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.27170575 |
| 33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.25666420 |
| 34 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.25500088 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.24464820 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.18593908 |
| 37 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16676753 |
| 38 | RNA transport_Homo sapiens_hsa03013 | 1.15201252 |
| 39 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.15184650 |
| 40 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.12950711 |
| 41 | Peroxisome_Homo sapiens_hsa04146 | 1.10646710 |
| 42 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.10380986 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.09164093 |
| 44 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.05236656 |
| 45 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.03221788 |
| 46 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.95968278 |
| 47 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.92067974 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.88769106 |
| 49 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.84613989 |
| 50 | Phototransduction_Homo sapiens_hsa04744 | 0.82268754 |
| 51 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.81661214 |
| 52 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.80745410 |
| 53 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.80091948 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.77006832 |
| 55 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.76289802 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.75612762 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.75174642 |
| 58 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.74947045 |
| 59 | Metabolic pathways_Homo sapiens_hsa01100 | 0.72759617 |
| 60 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.72570778 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.71194031 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.70629234 |
| 63 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.69721205 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.69115327 |
| 65 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.69029447 |
| 66 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.68061277 |
| 67 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.65209269 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.62507035 |
| 69 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62478285 |
| 70 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.61908713 |
| 71 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.61424324 |
| 72 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.61310600 |
| 73 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.60844790 |
| 74 | Olfactory transduction_Homo sapiens_hsa04740 | 0.60554448 |
| 75 | Sulfur relay system_Homo sapiens_hsa04122 | 0.59522044 |
| 76 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.55546720 |
| 77 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.54752703 |
| 78 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.53798936 |
| 79 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.51263543 |
| 80 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.50953441 |
| 81 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.50244468 |
| 82 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.50208373 |
| 83 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.49868705 |
| 84 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.47587618 |
| 85 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.46324598 |
| 86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.45908380 |
| 87 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.42428151 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.41878566 |
| 89 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.39316166 |
| 90 | Cell cycle_Homo sapiens_hsa04110 | 0.38772578 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.35829394 |
| 92 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.35598137 |
| 93 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34917448 |
| 94 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.34356558 |
| 95 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.32880232 |
| 96 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.32611984 |
| 97 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.32073573 |
| 98 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.30684964 |
| 99 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.30253007 |
| 100 | Mineral absorption_Homo sapiens_hsa04978 | 0.27851789 |

