SLC25A5P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.28645758
2ATP synthesis coupled proton transport (GO:0015986)5.84864953
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.84864953
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.83656321
5proteasome assembly (GO:0043248)5.31965234
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.93222998
7protein neddylation (GO:0045116)4.93012849
8chaperone-mediated protein transport (GO:0072321)4.89917363
9respiratory electron transport chain (GO:0022904)4.67887096
10electron transport chain (GO:0022900)4.62238218
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.58455477
12ribosomal small subunit assembly (GO:0000028)4.31826345
13protein deneddylation (GO:0000338)4.27117856
14cullin deneddylation (GO:0010388)4.22478719
15regulation of cellular amino acid metabolic process (GO:0006521)3.90998421
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.85382876
17peptidyl-histidine modification (GO:0018202)3.82059223
18pyrimidine nucleotide catabolic process (GO:0006244)3.81564921
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.79321677
20pseudouridine synthesis (GO:0001522)3.78874083
21signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72056308
22signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72056308
23signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72056308
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.70019125
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.70019125
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66416236
27protein-cofactor linkage (GO:0018065)3.64870721
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.62678552
29signal transduction involved in DNA damage checkpoint (GO:0072422)3.56021371
30signal transduction involved in DNA integrity checkpoint (GO:0072401)3.56021371
31regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.53975371
32signal transduction involved in cell cycle checkpoint (GO:0072395)3.52601747
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51942726
34negative regulation of ligase activity (GO:0051352)3.48650714
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.48650714
36positive regulation of isotype switching (GO:0045830)3.47678084
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45889194
38maturation of 5.8S rRNA (GO:0000460)3.43882694
39positive regulation of DNA recombination (GO:0045911)3.40742280
40ribosomal large subunit biogenesis (GO:0042273)3.40422149
41protein complex biogenesis (GO:0070271)3.39354006
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37086041
43ATP biosynthetic process (GO:0006754)3.35437306
44isotype switching (GO:0045190)3.33465526
45somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.33465526
46somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.33465526
47response to pheromone (GO:0019236)3.32141363
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29911855
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.26055974
50NADH dehydrogenase complex assembly (GO:0010257)3.26055974
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26055974
52translation (GO:0006412)3.24441931
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.21503905
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.21137002
55folic acid-containing compound biosynthetic process (GO:0009396)3.19266011
56termination of RNA polymerase III transcription (GO:0006386)3.18968479
57transcription elongation from RNA polymerase III promoter (GO:0006385)3.18968479
58mitochondrial respiratory chain complex assembly (GO:0033108)3.18393796
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18335851
60purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15222705
61respiratory chain complex IV assembly (GO:0008535)3.11772055
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11464008
63rRNA modification (GO:0000154)3.10778762
64rRNA processing (GO:0006364)3.08525140
65positive regulation of ligase activity (GO:0051351)3.08284069
66hydrogen ion transmembrane transport (GO:1902600)3.07559500
67positive regulation of cell cycle arrest (GO:0071158)3.06474460
68ribosomal small subunit biogenesis (GO:0042274)3.05928276
69histone mRNA metabolic process (GO:0008334)3.02853240
70DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.01868209
71rRNA metabolic process (GO:0016072)3.00188903
72deoxyribose phosphate catabolic process (GO:0046386)3.00187906
73protein targeting to mitochondrion (GO:0006626)2.99435202
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.96452895
75proton transport (GO:0015992)2.95927771
76deoxyribonucleotide catabolic process (GO:0009264)2.93982744
77oxidative phosphorylation (GO:0006119)2.92664561
78hydrogen transport (GO:0006818)2.91032021
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90647774
80regulation of podosome assembly (GO:0071801)2.90364662
81cotranslational protein targeting to membrane (GO:0006613)2.90174999
82regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.87943710
83positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.87943710
84protein targeting to ER (GO:0045047)2.86609322
85rRNA methylation (GO:0031167)2.85361858
86ribosome assembly (GO:0042255)2.85227582
87cytochrome complex assembly (GO:0017004)2.85131749
88cytidine deamination (GO:0009972)2.84384903
89cytidine metabolic process (GO:0046087)2.84384903
90cytidine catabolic process (GO:0006216)2.84384903
91positive regulation of muscle cell apoptotic process (GO:0010661)2.80893740
92ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80709669
93resolution of meiotic recombination intermediates (GO:0000712)2.80268204
94translational elongation (GO:0006414)2.78359832
95establishment of protein localization to mitochondrion (GO:0072655)2.77731270
96GTP biosynthetic process (GO:0006183)2.77381471
97regulation of cellular amine metabolic process (GO:0033238)2.76151636
98regulation of vitamin D biosynthetic process (GO:0060556)2.75728700
99transcription from mitochondrial promoter (GO:0006390)2.73849327
100viral transcription (GO:0019083)2.73820427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.26570616
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.62395588
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.26516173
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.00313572
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56123436
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.05954609
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.03511099
8VDR_23849224_ChIP-Seq_CD4+_Human2.69576830
9ELK1_19687146_ChIP-ChIP_HELA_Human2.66614392
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.63186649
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60248222
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.56865900
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42562726
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41169336
15ZNF274_21170338_ChIP-Seq_K562_Hela2.23832737
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.22852034
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.22449777
18IRF1_19129219_ChIP-ChIP_H3396_Human2.17171512
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15480294
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14419725
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13813554
22FOXP3_21729870_ChIP-Seq_TREG_Human2.09270756
23VDR_22108803_ChIP-Seq_LS180_Human1.97365548
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95728343
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.93202567
26IGF1R_20145208_ChIP-Seq_DFB_Human1.79112569
27MYC_18940864_ChIP-ChIP_HL60_Human1.77084667
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74917461
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66832735
30GABP_19822575_ChIP-Seq_HepG2_Human1.62672409
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60506586
32DCP1A_22483619_ChIP-Seq_HELA_Human1.59236048
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56697325
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.55280268
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54567312
36EWS_26573619_Chip-Seq_HEK293_Human1.52929958
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52694402
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52563728
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50616278
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50222004
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.48320532
42EZH2_22144423_ChIP-Seq_EOC_Human1.46854309
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46319957
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44441541
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42621326
46GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39457778
47NCOR_22424771_ChIP-Seq_293T_Human1.38869909
48PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33652139
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30972755
50TTF2_22483619_ChIP-Seq_HELA_Human1.27193656
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26824423
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.23931805
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21861376
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.18191673
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17557398
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15633649
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15054524
58AR_20517297_ChIP-Seq_VCAP_Human1.12817005
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12232806
60KDM5A_27292631_Chip-Seq_BREAST_Human1.11705131
61NANOG_20526341_ChIP-Seq_ESCs_Human1.10434693
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10362839
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10258569
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09328529
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08788733
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07573447
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06316538
68ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06071109
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03496501
70FOXA1_25329375_ChIP-Seq_VCAP_Human1.03224932
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03224932
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02403952
73NANOG_19829295_ChIP-Seq_ESCs_Human1.01183785
74SOX2_19829295_ChIP-Seq_ESCs_Human1.01183785
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00527288
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00466547
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00441615
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00196044
79XRN2_22483619_ChIP-Seq_HELA_Human0.99888995
80FUS_26573619_Chip-Seq_HEK293_Human0.99520549
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98317102
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97108056
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96976329
84FOXH1_21741376_ChIP-Seq_EPCs_Human0.95212349
85P300_19829295_ChIP-Seq_ESCs_Human0.94463029
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93005197
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92416849
88TP53_22573176_ChIP-Seq_HFKS_Human0.92293958
89RBPJ_21746931_ChIP-Seq_IB4_Human0.91402842
90PHF8_20622853_ChIP-Seq_HELA_Human0.91327212
91GATA6_21074721_ChIP-Seq_CACO-2_Human0.90950005
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.90559357
93ER_23166858_ChIP-Seq_MCF-7_Human0.88644023
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88311348
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88104988
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.88051669
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.87830038
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87052818
99IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85715202
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85363988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.00911190
2MP0002102_abnormal_ear_morphology3.87176365
3MP0004145_abnormal_muscle_electrophysio3.86413181
4MP0000372_irregular_coat_pigmentation3.83152020
5MP0001873_stomach_inflammation3.32189258
6MP0009333_abnormal_splenocyte_physiolog2.73870743
7MP0008058_abnormal_DNA_repair2.71379135
8MP0004147_increased_porphyrin_level2.71342510
9MP0009379_abnormal_foot_pigmentation2.54410633
10MP0006036_abnormal_mitochondrial_physio2.50602186
11MP0003186_abnormal_redox_activity2.50483250
12MP0003693_abnormal_embryo_hatching2.35118224
13MP0003646_muscle_fatigue2.24065201
14MP0003806_abnormal_nucleotide_metabolis2.23671216
15MP0005645_abnormal_hypothalamus_physiol2.23426560
16MP0003195_calcinosis2.19978381
17MP0001835_abnormal_antigen_presentation2.13187601
18MP0008057_abnormal_DNA_replication2.10726591
19MP0003718_maternal_effect1.79790890
20MP0010307_abnormal_tumor_latency1.77205315
21MP0002837_dystrophic_cardiac_calcinosis1.76002757
22MP0004957_abnormal_blastocyst_morpholog1.75891238
23MP0010094_abnormal_chromosome_stability1.71694392
24MP0004782_abnormal_surfactant_physiolog1.65154770
25MP0006054_spinal_hemorrhage1.60648504
26MP0005171_absent_coat_pigmentation1.54460617
27MP0005379_endocrine/exocrine_gland_phen1.49779354
28MP0008872_abnormal_physiological_respon1.49383357
29MP0001968_abnormal_touch/_nociception1.46240652
30MP0002163_abnormal_gland_morphology1.45237751
31MP0009785_altered_susceptibility_to1.41859025
32MP0008877_abnormal_DNA_methylation1.39040545
33MP0003786_premature_aging1.36838589
34MP0004142_abnormal_muscle_tone1.36768771
35MP0003077_abnormal_cell_cycle1.33759521
36MP0008875_abnormal_xenobiotic_pharmacok1.30559576
37MP0006035_abnormal_mitochondrial_morpho1.29964969
38MP0002160_abnormal_reproductive_system1.28413804
39MP0008007_abnormal_cellular_replicative1.27786679
40MP0000685_abnormal_immune_system1.26664924
41MP0003763_abnormal_thymus_physiology1.26642748
42MP0005408_hypopigmentation1.26319011
43MP0001790_abnormal_immune_system1.24859559
44MP0005387_immune_system_phenotype1.24859559
45MP0005670_abnormal_white_adipose1.24464271
46MP0002148_abnormal_hypersensitivity_rea1.19954820
47MP0005167_abnormal_blood-brain_barrier1.18987309
48MP0005075_abnormal_melanosome_morpholog1.16704358
49MP0002938_white_spotting1.14899064
50MP0008775_abnormal_heart_ventricle1.13195678
51MP0006276_abnormal_autonomic_nervous1.12793861
52MP0004215_abnormal_myocardial_fiber1.08486026
53MP0002138_abnormal_hepatobiliary_system1.06427217
54MP0001764_abnormal_homeostasis1.06336931
55MP0001188_hyperpigmentation1.03408013
56MP0009697_abnormal_copulation1.01602530
57MP0005084_abnormal_gallbladder_morpholo1.01177295
58MP0002693_abnormal_pancreas_physiology0.99278998
59MP0003011_delayed_dark_adaptation0.98534541
60MP0001905_abnormal_dopamine_level0.97793379
61MP0005360_urolithiasis0.97470233
62MP0005636_abnormal_mineral_homeostasis0.96685092
63MP0005389_reproductive_system_phenotype0.96621438
64MP0002095_abnormal_skin_pigmentation0.96211781
65MP0004885_abnormal_endolymph0.93446134
66MP0003122_maternal_imprinting0.92432565
67MP0006072_abnormal_retinal_apoptosis0.88004927
68MP0001800_abnormal_humoral_immune0.87352374
69MP0008932_abnormal_embryonic_tissue0.86277183
70MP0005646_abnormal_pituitary_gland0.85763289
71MP0004742_abnormal_vestibular_system0.83946415
72MP0002210_abnormal_sex_determination0.82757804
73MP0002736_abnormal_nociception_after0.81516413
74MP0005551_abnormal_eye_electrophysiolog0.77910421
75MP0001485_abnormal_pinna_reflex0.76407777
76MP0005253_abnormal_eye_physiology0.75023347
77MP0001663_abnormal_digestive_system0.74141639
78MP0003111_abnormal_nucleus_morphology0.73981038
79MP0006292_abnormal_olfactory_placode0.73192374
80MP0005266_abnormal_metabolism0.71383231
81MP0001119_abnormal_female_reproductive0.70833855
82MP0009643_abnormal_urine_homeostasis0.70408447
83MP0003880_abnormal_central_pattern0.70355514
84MP0002405_respiratory_system_inflammati0.69517997
85MP0000653_abnormal_sex_gland0.69092980
86MP0001853_heart_inflammation0.69067240
87MP0005085_abnormal_gallbladder_physiolo0.67988948
88MP0003567_abnormal_fetal_cardiomyocyte0.66831641
89MP0001929_abnormal_gametogenesis0.66492079
90MP0005410_abnormal_fertilization0.66334618
91MP0004134_abnormal_chest_morphology0.65481209
92MP0001919_abnormal_reproductive_system0.65025483
93MP0010030_abnormal_orbit_morphology0.64861807
94MP0005083_abnormal_biliary_tract0.64601453
95MP0005395_other_phenotype0.62982076
96MP0005174_abnormal_tail_pigmentation0.61220943
97MP0005365_abnormal_bile_salt0.60223078
98MP0003787_abnormal_imprinting0.59064050
99MP0005332_abnormal_amino_acid0.58700683
100MP0001502_abnormal_circadian_rhythm0.57742895

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.07551234
2Acute encephalopathy (HP:0006846)4.48785200
3Progressive macrocephaly (HP:0004481)4.44753958
4Increased CSF lactate (HP:0002490)4.43720452
5Abnormal mitochondria in muscle tissue (HP:0008316)4.41567885
63-Methylglutaconic aciduria (HP:0003535)4.29315194
7Mitochondrial inheritance (HP:0001427)4.23289501
8Cerebral edema (HP:0002181)3.77950239
9Increased serum lactate (HP:0002151)3.54714426
10Abnormality of the labia minora (HP:0012880)3.54092731
11Abnormality of alanine metabolism (HP:0010916)3.46842253
12Hyperalaninemia (HP:0003348)3.46842253
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.46842253
14Hepatic necrosis (HP:0002605)3.40988248
15Hepatocellular necrosis (HP:0001404)3.36136942
16Increased hepatocellular lipid droplets (HP:0006565)3.19907610
17Lipid accumulation in hepatocytes (HP:0006561)2.87660241
18Lactic acidosis (HP:0003128)2.86479106
19Abnormal number of erythroid precursors (HP:0012131)2.86023300
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81816000
21Abnormality of cells of the erythroid lineage (HP:0012130)2.81162209
22Renal Fanconi syndrome (HP:0001994)2.77691097
23Optic disc pallor (HP:0000543)2.77205089
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73126484
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73126484
26Lethargy (HP:0001254)2.68807147
27Stenosis of the external auditory canal (HP:0000402)2.64309374
28Increased intramyocellular lipid droplets (HP:0012240)2.63245454
29Central scotoma (HP:0000603)2.48221741
30Progressive microcephaly (HP:0000253)2.47290269
31Generalized aminoaciduria (HP:0002909)2.42258093
32Respiratory failure (HP:0002878)2.40028466
33Abnormality of urine glucose concentration (HP:0011016)2.39733008
34Glycosuria (HP:0003076)2.39733008
35Methylmalonic acidemia (HP:0002912)2.39087696
36Exercise intolerance (HP:0003546)2.35810511
37Aplastic anemia (HP:0001915)2.32242543
38Constricted visual fields (HP:0001133)2.31981186
39Colon cancer (HP:0003003)2.27691762
40Poor head control (HP:0002421)2.27380568
41Respiratory difficulties (HP:0002880)2.25968323
42Supernumerary spleens (HP:0009799)2.25613450
43Exertional dyspnea (HP:0002875)2.24261283
44Leukodystrophy (HP:0002415)2.23182790
45Hypothermia (HP:0002045)2.17340522
46Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17188401
47Elevated erythrocyte sedimentation rate (HP:0003565)2.17009428
48Pancreatic cysts (HP:0001737)2.16759089
49Posterior subcapsular cataract (HP:0007787)2.10208137
50Increased muscle lipid content (HP:0009058)2.07522462
51Increased serum pyruvate (HP:0003542)2.07102231
52Nausea (HP:0002018)2.06961270
53Hypokalemic alkalosis (HP:0001949)2.06882960
54Abnormality of serum amino acid levels (HP:0003112)2.06007627
55Increased IgM level (HP:0003496)2.02159632
56Stomatitis (HP:0010280)2.02027651
57Hypoproteinemia (HP:0003075)1.99435046
58Aplasia/Hypoplasia of the fovea (HP:0008060)1.99008142
59Hypoplasia of the fovea (HP:0007750)1.99008142
60Methylmalonic aciduria (HP:0012120)1.98555380
61Abnormality of renal resorption (HP:0011038)1.98421940
62Alkalosis (HP:0001948)1.97823638
63Molar tooth sign on MRI (HP:0002419)1.96352843
64Abnormality of midbrain morphology (HP:0002418)1.96352843
65Degeneration of anterior horn cells (HP:0002398)1.93525119
66Abnormality of the anterior horn cell (HP:0006802)1.93525119
67CNS hypomyelination (HP:0003429)1.92260068
68Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91763636
69Attenuation of retinal blood vessels (HP:0007843)1.90590056
70Abnormality of the fovea (HP:0000493)1.89404605
71Pancreatic fibrosis (HP:0100732)1.88730929
72Metabolic alkalosis (HP:0200114)1.87566916
73Parakeratosis (HP:0001036)1.86918911
74Abnormality of the pons (HP:0007361)1.86787214
75Congenital stationary night blindness (HP:0007642)1.86045043
76Type I transferrin isoform profile (HP:0003642)1.85696125
77CNS demyelination (HP:0007305)1.82390073
78Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81686422
79Hypoglycemic coma (HP:0001325)1.80013192
80Abnormal pancreas size (HP:0012094)1.79798435
81Neutropenia (HP:0001875)1.79543276
82Abnormal protein N-linked glycosylation (HP:0012347)1.79397262
83Abnormal protein glycosylation (HP:0012346)1.79397262
84Abnormal glycosylation (HP:0012345)1.79397262
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79397262
86Polyuria (HP:0000103)1.78199386
87Abnormality of methionine metabolism (HP:0010901)1.77041435
88Macrocytic anemia (HP:0001972)1.75751815
89Abnormality of T cell physiology (HP:0011840)1.75177281
90Abnormality of homocysteine metabolism (HP:0010919)1.73824798
91Homocystinuria (HP:0002156)1.73824798
92Abnormality of T cells (HP:0002843)1.73695487
93Optic neuritis (HP:0100653)1.73358679
94Retrobulbar optic neuritis (HP:0100654)1.73358679
95Abnormality of T cell number (HP:0011839)1.72651458
96Stomach cancer (HP:0012126)1.71961055
97Abnormality of the vitamin B12 metabolism (HP:0004341)1.71909272
98X-linked dominant inheritance (HP:0001423)1.71654930
99Abnormality of magnesium homeostasis (HP:0004921)1.71159351
100Sparse eyelashes (HP:0000653)1.71003990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.25899415
2PDK24.77502661
3TXK3.73273579
4BCKDK3.40226315
5MST43.22844587
6EIF2AK12.99561326
7ADRBK22.58640707
8MUSK2.49094027
9BUB12.42064809
10VRK12.28398386
11EIF2AK32.27809212
12GRK12.14962139
13SRPK12.13309288
14ZAK2.11867931
15NME22.08007948
16NME11.85915361
17TLK11.84595363
18TIE11.79538878
19NEK11.73173089
20NUAK11.71884567
21TSSK61.60355685
22PLK31.51216848
23MKNK11.37695001
24PASK1.36654576
25MAP2K61.25800987
26STK161.25422908
27ITK1.22081022
28DYRK21.16490230
29TEC1.12543879
30MAP3K121.11373790
31MAPKAPK51.02086652
32PBK0.98512312
33BMPR1B0.98168635
34KDR0.92800158
35WNK40.91949841
36OXSR10.89327156
37TAF10.89258157
38FRK0.89239832
39TNIK0.88986101
40BTK0.86902325
41PLK10.84663471
42MAP3K90.82581886
43PRKCG0.82424839
44BMPR20.81272627
45GRK50.80314451
46NLK0.75937212
47MAP4K10.71000831
48MKNK20.68526242
49PINK10.67677752
50INSRR0.66642460
51ADRBK10.66609509
52FLT30.66272174
53STK390.65284433
54WNK30.64948266
55PLK40.64678816
56EIF2AK20.59905105
57SYK0.59645700
58PLK20.57591722
59FGFR20.56783830
60RPS6KA50.56000852
61CSNK2A10.55986764
62AURKB0.54235244
63GRK70.53329150
64FGFR10.52137306
65CAMKK20.51677311
66MYLK0.50855878
67PIK3CA0.48437933
68PAK30.48194050
69ILK0.47344555
70ATR0.46750296
71DAPK10.46481648
72CCNB10.45967732
73PRKCI0.45552764
74CAMK2A0.44882644
75ALK0.42842424
76CSNK2A20.39608195
77TGFBR10.38512456
78NTRK20.38163167
79PHKG10.38150410
80PHKG20.38150410
81DAPK30.38104959
82CHEK20.37655703
83PRKCH0.37293478
84TRIM280.35743151
85PRKCA0.35591552
86PRKACA0.35013599
87TAOK30.34142648
88WEE10.34068727
89PRKCE0.32517657
90CDC70.32372688
91IKBKB0.32264065
92CSNK1E0.32062713
93ACVR1B0.27078112
94PRKCD0.27040831
95STK110.26981105
96PRKCQ0.26912502
97OBSCN0.25850244
98RIPK40.25792982
99ABL20.25497267
100ATM0.24823049

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.12814579
2Oxidative phosphorylation_Homo sapiens_hsa001904.07249600
3Parkinsons disease_Homo sapiens_hsa050123.71689207
4Ribosome_Homo sapiens_hsa030103.47729295
5Protein export_Homo sapiens_hsa030603.03420897
6Huntingtons disease_Homo sapiens_hsa050162.54795598
7One carbon pool by folate_Homo sapiens_hsa006702.42721064
8Alzheimers disease_Homo sapiens_hsa050102.24779126
9RNA polymerase_Homo sapiens_hsa030202.22105839
10Homologous recombination_Homo sapiens_hsa034402.10432812
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03008615
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.97481450
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94563319
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81822374
15Propanoate metabolism_Homo sapiens_hsa006401.80579059
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75463848
17Cardiac muscle contraction_Homo sapiens_hsa042601.53064854
18Basal transcription factors_Homo sapiens_hsa030221.52108940
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46346610
20Nitrogen metabolism_Homo sapiens_hsa009101.40541404
21Fatty acid elongation_Homo sapiens_hsa000621.39968792
22Folate biosynthesis_Homo sapiens_hsa007901.38107212
23Butanoate metabolism_Homo sapiens_hsa006501.35278033
24RNA degradation_Homo sapiens_hsa030181.34068547
25Pyrimidine metabolism_Homo sapiens_hsa002401.31391986
26Mismatch repair_Homo sapiens_hsa034301.30336150
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27869793
28Primary immunodeficiency_Homo sapiens_hsa053401.27149590
29Pyruvate metabolism_Homo sapiens_hsa006201.25719173
30Fatty acid biosynthesis_Homo sapiens_hsa000611.22088074
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21953845
32Sulfur metabolism_Homo sapiens_hsa009201.19524202
33RNA transport_Homo sapiens_hsa030131.18383515
34Regulation of autophagy_Homo sapiens_hsa041401.18317429
35Purine metabolism_Homo sapiens_hsa002301.18315730
36Vitamin B6 metabolism_Homo sapiens_hsa007501.17982835
37Linoleic acid metabolism_Homo sapiens_hsa005911.15790898
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15495829
39DNA replication_Homo sapiens_hsa030301.13279416
40Fanconi anemia pathway_Homo sapiens_hsa034601.05038913
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02972480
42Peroxisome_Homo sapiens_hsa041461.02492097
43Allograft rejection_Homo sapiens_hsa053301.01299653
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99894200
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98357235
46Nucleotide excision repair_Homo sapiens_hsa034200.97761054
47Sulfur relay system_Homo sapiens_hsa041220.95495496
48Rheumatoid arthritis_Homo sapiens_hsa053230.93532797
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.93270409
50Base excision repair_Homo sapiens_hsa034100.93153231
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89434765
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84921290
53Spliceosome_Homo sapiens_hsa030400.81417745
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.81261607
55Metabolic pathways_Homo sapiens_hsa011000.81053959
56Phototransduction_Homo sapiens_hsa047440.80643582
57Collecting duct acid secretion_Homo sapiens_hsa049660.76173783
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.76024570
59Fat digestion and absorption_Homo sapiens_hsa049750.70819750
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69614348
61Type I diabetes mellitus_Homo sapiens_hsa049400.69002581
62Arachidonic acid metabolism_Homo sapiens_hsa005900.67634198
63Steroid biosynthesis_Homo sapiens_hsa001000.66082821
64Ether lipid metabolism_Homo sapiens_hsa005650.64009053
65Tryptophan metabolism_Homo sapiens_hsa003800.63436740
66Asthma_Homo sapiens_hsa053100.62856849
67Non-homologous end-joining_Homo sapiens_hsa034500.60565958
68Graft-versus-host disease_Homo sapiens_hsa053320.60339779
69Olfactory transduction_Homo sapiens_hsa047400.59785728
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59543646
71Carbon metabolism_Homo sapiens_hsa012000.59109811
72Autoimmune thyroid disease_Homo sapiens_hsa053200.56324860
73Glutathione metabolism_Homo sapiens_hsa004800.54794903
74Arginine biosynthesis_Homo sapiens_hsa002200.54781240
75Chemical carcinogenesis_Homo sapiens_hsa052040.53633473
76Fatty acid metabolism_Homo sapiens_hsa012120.52511086
77Biosynthesis of amino acids_Homo sapiens_hsa012300.52007061
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51552135
79Hematopoietic cell lineage_Homo sapiens_hsa046400.48044795
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47440961
81Caffeine metabolism_Homo sapiens_hsa002320.47113778
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46365291
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.46080787
84Systemic lupus erythematosus_Homo sapiens_hsa053220.45956259
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44445387
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43248193
87Retinol metabolism_Homo sapiens_hsa008300.42837521
88N-Glycan biosynthesis_Homo sapiens_hsa005100.41034471
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40965830
90Tyrosine metabolism_Homo sapiens_hsa003500.40302711
91Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38770138
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36721501
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34628192
94Selenocompound metabolism_Homo sapiens_hsa004500.34273143
95African trypanosomiasis_Homo sapiens_hsa051430.33152862
96Cell cycle_Homo sapiens_hsa041100.32071504
97Antigen processing and presentation_Homo sapiens_hsa046120.31589518
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31517551
99Starch and sucrose metabolism_Homo sapiens_hsa005000.28606217
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26491478

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