

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 6.28645758 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.84864953 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.84864953 |
| 4 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.83656321 |
| 5 | proteasome assembly (GO:0043248) | 5.31965234 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.93222998 |
| 7 | protein neddylation (GO:0045116) | 4.93012849 |
| 8 | chaperone-mediated protein transport (GO:0072321) | 4.89917363 |
| 9 | respiratory electron transport chain (GO:0022904) | 4.67887096 |
| 10 | electron transport chain (GO:0022900) | 4.62238218 |
| 11 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 4.58455477 |
| 12 | ribosomal small subunit assembly (GO:0000028) | 4.31826345 |
| 13 | protein deneddylation (GO:0000338) | 4.27117856 |
| 14 | cullin deneddylation (GO:0010388) | 4.22478719 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.90998421 |
| 16 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.85382876 |
| 17 | peptidyl-histidine modification (GO:0018202) | 3.82059223 |
| 18 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.81564921 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.79321677 |
| 20 | pseudouridine synthesis (GO:0001522) | 3.78874083 |
| 21 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.72056308 |
| 22 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.72056308 |
| 23 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.72056308 |
| 24 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.70019125 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.70019125 |
| 26 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.66416236 |
| 27 | protein-cofactor linkage (GO:0018065) | 3.64870721 |
| 28 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.62678552 |
| 29 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.56021371 |
| 30 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.56021371 |
| 31 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.53975371 |
| 32 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.52601747 |
| 33 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.51942726 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.48650714 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.48650714 |
| 36 | positive regulation of isotype switching (GO:0045830) | 3.47678084 |
| 37 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.45889194 |
| 38 | maturation of 5.8S rRNA (GO:0000460) | 3.43882694 |
| 39 | positive regulation of DNA recombination (GO:0045911) | 3.40742280 |
| 40 | ribosomal large subunit biogenesis (GO:0042273) | 3.40422149 |
| 41 | protein complex biogenesis (GO:0070271) | 3.39354006 |
| 42 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.37086041 |
| 43 | ATP biosynthetic process (GO:0006754) | 3.35437306 |
| 44 | isotype switching (GO:0045190) | 3.33465526 |
| 45 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.33465526 |
| 46 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.33465526 |
| 47 | response to pheromone (GO:0019236) | 3.32141363 |
| 48 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.29911855 |
| 49 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.26055974 |
| 50 | NADH dehydrogenase complex assembly (GO:0010257) | 3.26055974 |
| 51 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.26055974 |
| 52 | translation (GO:0006412) | 3.24441931 |
| 53 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.21503905 |
| 54 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.21137002 |
| 55 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.19266011 |
| 56 | termination of RNA polymerase III transcription (GO:0006386) | 3.18968479 |
| 57 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.18968479 |
| 58 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.18393796 |
| 59 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.18335851 |
| 60 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.15222705 |
| 61 | respiratory chain complex IV assembly (GO:0008535) | 3.11772055 |
| 62 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.11464008 |
| 63 | rRNA modification (GO:0000154) | 3.10778762 |
| 64 | rRNA processing (GO:0006364) | 3.08525140 |
| 65 | positive regulation of ligase activity (GO:0051351) | 3.08284069 |
| 66 | hydrogen ion transmembrane transport (GO:1902600) | 3.07559500 |
| 67 | positive regulation of cell cycle arrest (GO:0071158) | 3.06474460 |
| 68 | ribosomal small subunit biogenesis (GO:0042274) | 3.05928276 |
| 69 | histone mRNA metabolic process (GO:0008334) | 3.02853240 |
| 70 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.01868209 |
| 71 | rRNA metabolic process (GO:0016072) | 3.00188903 |
| 72 | deoxyribose phosphate catabolic process (GO:0046386) | 3.00187906 |
| 73 | protein targeting to mitochondrion (GO:0006626) | 2.99435202 |
| 74 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.96452895 |
| 75 | proton transport (GO:0015992) | 2.95927771 |
| 76 | deoxyribonucleotide catabolic process (GO:0009264) | 2.93982744 |
| 77 | oxidative phosphorylation (GO:0006119) | 2.92664561 |
| 78 | hydrogen transport (GO:0006818) | 2.91032021 |
| 79 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.90647774 |
| 80 | regulation of podosome assembly (GO:0071801) | 2.90364662 |
| 81 | cotranslational protein targeting to membrane (GO:0006613) | 2.90174999 |
| 82 | regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139) | 2.87943710 |
| 83 | positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141) | 2.87943710 |
| 84 | protein targeting to ER (GO:0045047) | 2.86609322 |
| 85 | rRNA methylation (GO:0031167) | 2.85361858 |
| 86 | ribosome assembly (GO:0042255) | 2.85227582 |
| 87 | cytochrome complex assembly (GO:0017004) | 2.85131749 |
| 88 | cytidine deamination (GO:0009972) | 2.84384903 |
| 89 | cytidine metabolic process (GO:0046087) | 2.84384903 |
| 90 | cytidine catabolic process (GO:0006216) | 2.84384903 |
| 91 | positive regulation of muscle cell apoptotic process (GO:0010661) | 2.80893740 |
| 92 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.80709669 |
| 93 | resolution of meiotic recombination intermediates (GO:0000712) | 2.80268204 |
| 94 | translational elongation (GO:0006414) | 2.78359832 |
| 95 | establishment of protein localization to mitochondrion (GO:0072655) | 2.77731270 |
| 96 | GTP biosynthetic process (GO:0006183) | 2.77381471 |
| 97 | regulation of cellular amine metabolic process (GO:0033238) | 2.76151636 |
| 98 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.75728700 |
| 99 | transcription from mitochondrial promoter (GO:0006390) | 2.73849327 |
| 100 | viral transcription (GO:0019083) | 2.73820427 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.26570616 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.62395588 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.26516173 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.00313572 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56123436 |
| 6 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05954609 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.03511099 |
| 8 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.69576830 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.66614392 |
| 10 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.63186649 |
| 11 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.60248222 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.56865900 |
| 13 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.42562726 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.41169336 |
| 15 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.23832737 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.22852034 |
| 17 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.22449777 |
| 18 | IRF1_19129219_ChIP-ChIP_H3396_Human | 2.17171512 |
| 19 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.15480294 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.14419725 |
| 21 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.13813554 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.09270756 |
| 23 | VDR_22108803_ChIP-Seq_LS180_Human | 1.97365548 |
| 24 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.95728343 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.93202567 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.79112569 |
| 27 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77084667 |
| 28 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.74917461 |
| 29 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.66832735 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.62672409 |
| 31 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.60506586 |
| 32 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.59236048 |
| 33 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.56697325 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.55280268 |
| 35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.54567312 |
| 36 | EWS_26573619_Chip-Seq_HEK293_Human | 1.52929958 |
| 37 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.52694402 |
| 38 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.52563728 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.50616278 |
| 40 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.50222004 |
| 41 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.48320532 |
| 42 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.46854309 |
| 43 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.46319957 |
| 44 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.44441541 |
| 45 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.42621326 |
| 46 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.39457778 |
| 47 | NCOR_22424771_ChIP-Seq_293T_Human | 1.38869909 |
| 48 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.33652139 |
| 49 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.30972755 |
| 50 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.27193656 |
| 51 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.26824423 |
| 52 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23931805 |
| 53 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.21861376 |
| 54 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.18191673 |
| 55 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.17557398 |
| 56 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.15633649 |
| 57 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.15054524 |
| 58 | AR_20517297_ChIP-Seq_VCAP_Human | 1.12817005 |
| 59 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.12232806 |
| 60 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.11705131 |
| 61 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.10434693 |
| 62 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.10362839 |
| 63 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.10258569 |
| 64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.09328529 |
| 65 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.08788733 |
| 66 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.07573447 |
| 67 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.06316538 |
| 68 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.06071109 |
| 69 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.03496501 |
| 70 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.03224932 |
| 71 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.03224932 |
| 72 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.02403952 |
| 73 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.01183785 |
| 74 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.01183785 |
| 75 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.00527288 |
| 76 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 1.00466547 |
| 77 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.00441615 |
| 78 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.00196044 |
| 79 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.99888995 |
| 80 | FUS_26573619_Chip-Seq_HEK293_Human | 0.99520549 |
| 81 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.98317102 |
| 82 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.97108056 |
| 83 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.96976329 |
| 84 | FOXH1_21741376_ChIP-Seq_EPCs_Human | 0.95212349 |
| 85 | P300_19829295_ChIP-Seq_ESCs_Human | 0.94463029 |
| 86 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.93005197 |
| 87 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.92416849 |
| 88 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.92293958 |
| 89 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.91402842 |
| 90 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.91327212 |
| 91 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.90950005 |
| 92 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.90559357 |
| 93 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.88644023 |
| 94 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.88311348 |
| 95 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.88104988 |
| 96 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.88051669 |
| 97 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.87830038 |
| 98 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.87052818 |
| 99 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.85715202 |
| 100 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.85363988 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.00911190 |
| 2 | MP0002102_abnormal_ear_morphology | 3.87176365 |
| 3 | MP0004145_abnormal_muscle_electrophysio | 3.86413181 |
| 4 | MP0000372_irregular_coat_pigmentation | 3.83152020 |
| 5 | MP0001873_stomach_inflammation | 3.32189258 |
| 6 | MP0009333_abnormal_splenocyte_physiolog | 2.73870743 |
| 7 | MP0008058_abnormal_DNA_repair | 2.71379135 |
| 8 | MP0004147_increased_porphyrin_level | 2.71342510 |
| 9 | MP0009379_abnormal_foot_pigmentation | 2.54410633 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.50602186 |
| 11 | MP0003186_abnormal_redox_activity | 2.50483250 |
| 12 | MP0003693_abnormal_embryo_hatching | 2.35118224 |
| 13 | MP0003646_muscle_fatigue | 2.24065201 |
| 14 | MP0003806_abnormal_nucleotide_metabolis | 2.23671216 |
| 15 | MP0005645_abnormal_hypothalamus_physiol | 2.23426560 |
| 16 | MP0003195_calcinosis | 2.19978381 |
| 17 | MP0001835_abnormal_antigen_presentation | 2.13187601 |
| 18 | MP0008057_abnormal_DNA_replication | 2.10726591 |
| 19 | MP0003718_maternal_effect | 1.79790890 |
| 20 | MP0010307_abnormal_tumor_latency | 1.77205315 |
| 21 | MP0002837_dystrophic_cardiac_calcinosis | 1.76002757 |
| 22 | MP0004957_abnormal_blastocyst_morpholog | 1.75891238 |
| 23 | MP0010094_abnormal_chromosome_stability | 1.71694392 |
| 24 | MP0004782_abnormal_surfactant_physiolog | 1.65154770 |
| 25 | MP0006054_spinal_hemorrhage | 1.60648504 |
| 26 | MP0005171_absent_coat_pigmentation | 1.54460617 |
| 27 | MP0005379_endocrine/exocrine_gland_phen | 1.49779354 |
| 28 | MP0008872_abnormal_physiological_respon | 1.49383357 |
| 29 | MP0001968_abnormal_touch/_nociception | 1.46240652 |
| 30 | MP0002163_abnormal_gland_morphology | 1.45237751 |
| 31 | MP0009785_altered_susceptibility_to | 1.41859025 |
| 32 | MP0008877_abnormal_DNA_methylation | 1.39040545 |
| 33 | MP0003786_premature_aging | 1.36838589 |
| 34 | MP0004142_abnormal_muscle_tone | 1.36768771 |
| 35 | MP0003077_abnormal_cell_cycle | 1.33759521 |
| 36 | MP0008875_abnormal_xenobiotic_pharmacok | 1.30559576 |
| 37 | MP0006035_abnormal_mitochondrial_morpho | 1.29964969 |
| 38 | MP0002160_abnormal_reproductive_system | 1.28413804 |
| 39 | MP0008007_abnormal_cellular_replicative | 1.27786679 |
| 40 | MP0000685_abnormal_immune_system | 1.26664924 |
| 41 | MP0003763_abnormal_thymus_physiology | 1.26642748 |
| 42 | MP0005408_hypopigmentation | 1.26319011 |
| 43 | MP0001790_abnormal_immune_system | 1.24859559 |
| 44 | MP0005387_immune_system_phenotype | 1.24859559 |
| 45 | MP0005670_abnormal_white_adipose | 1.24464271 |
| 46 | MP0002148_abnormal_hypersensitivity_rea | 1.19954820 |
| 47 | MP0005167_abnormal_blood-brain_barrier | 1.18987309 |
| 48 | MP0005075_abnormal_melanosome_morpholog | 1.16704358 |
| 49 | MP0002938_white_spotting | 1.14899064 |
| 50 | MP0008775_abnormal_heart_ventricle | 1.13195678 |
| 51 | MP0006276_abnormal_autonomic_nervous | 1.12793861 |
| 52 | MP0004215_abnormal_myocardial_fiber | 1.08486026 |
| 53 | MP0002138_abnormal_hepatobiliary_system | 1.06427217 |
| 54 | MP0001764_abnormal_homeostasis | 1.06336931 |
| 55 | MP0001188_hyperpigmentation | 1.03408013 |
| 56 | MP0009697_abnormal_copulation | 1.01602530 |
| 57 | MP0005084_abnormal_gallbladder_morpholo | 1.01177295 |
| 58 | MP0002693_abnormal_pancreas_physiology | 0.99278998 |
| 59 | MP0003011_delayed_dark_adaptation | 0.98534541 |
| 60 | MP0001905_abnormal_dopamine_level | 0.97793379 |
| 61 | MP0005360_urolithiasis | 0.97470233 |
| 62 | MP0005636_abnormal_mineral_homeostasis | 0.96685092 |
| 63 | MP0005389_reproductive_system_phenotype | 0.96621438 |
| 64 | MP0002095_abnormal_skin_pigmentation | 0.96211781 |
| 65 | MP0004885_abnormal_endolymph | 0.93446134 |
| 66 | MP0003122_maternal_imprinting | 0.92432565 |
| 67 | MP0006072_abnormal_retinal_apoptosis | 0.88004927 |
| 68 | MP0001800_abnormal_humoral_immune | 0.87352374 |
| 69 | MP0008932_abnormal_embryonic_tissue | 0.86277183 |
| 70 | MP0005646_abnormal_pituitary_gland | 0.85763289 |
| 71 | MP0004742_abnormal_vestibular_system | 0.83946415 |
| 72 | MP0002210_abnormal_sex_determination | 0.82757804 |
| 73 | MP0002736_abnormal_nociception_after | 0.81516413 |
| 74 | MP0005551_abnormal_eye_electrophysiolog | 0.77910421 |
| 75 | MP0001485_abnormal_pinna_reflex | 0.76407777 |
| 76 | MP0005253_abnormal_eye_physiology | 0.75023347 |
| 77 | MP0001663_abnormal_digestive_system | 0.74141639 |
| 78 | MP0003111_abnormal_nucleus_morphology | 0.73981038 |
| 79 | MP0006292_abnormal_olfactory_placode | 0.73192374 |
| 80 | MP0005266_abnormal_metabolism | 0.71383231 |
| 81 | MP0001119_abnormal_female_reproductive | 0.70833855 |
| 82 | MP0009643_abnormal_urine_homeostasis | 0.70408447 |
| 83 | MP0003880_abnormal_central_pattern | 0.70355514 |
| 84 | MP0002405_respiratory_system_inflammati | 0.69517997 |
| 85 | MP0000653_abnormal_sex_gland | 0.69092980 |
| 86 | MP0001853_heart_inflammation | 0.69067240 |
| 87 | MP0005085_abnormal_gallbladder_physiolo | 0.67988948 |
| 88 | MP0003567_abnormal_fetal_cardiomyocyte | 0.66831641 |
| 89 | MP0001929_abnormal_gametogenesis | 0.66492079 |
| 90 | MP0005410_abnormal_fertilization | 0.66334618 |
| 91 | MP0004134_abnormal_chest_morphology | 0.65481209 |
| 92 | MP0001919_abnormal_reproductive_system | 0.65025483 |
| 93 | MP0010030_abnormal_orbit_morphology | 0.64861807 |
| 94 | MP0005083_abnormal_biliary_tract | 0.64601453 |
| 95 | MP0005395_other_phenotype | 0.62982076 |
| 96 | MP0005174_abnormal_tail_pigmentation | 0.61220943 |
| 97 | MP0005365_abnormal_bile_salt | 0.60223078 |
| 98 | MP0003787_abnormal_imprinting | 0.59064050 |
| 99 | MP0005332_abnormal_amino_acid | 0.58700683 |
| 100 | MP0001502_abnormal_circadian_rhythm | 0.57742895 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.07551234 |
| 2 | Acute encephalopathy (HP:0006846) | 4.48785200 |
| 3 | Progressive macrocephaly (HP:0004481) | 4.44753958 |
| 4 | Increased CSF lactate (HP:0002490) | 4.43720452 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.41567885 |
| 6 | 3-Methylglutaconic aciduria (HP:0003535) | 4.29315194 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.23289501 |
| 8 | Cerebral edema (HP:0002181) | 3.77950239 |
| 9 | Increased serum lactate (HP:0002151) | 3.54714426 |
| 10 | Abnormality of the labia minora (HP:0012880) | 3.54092731 |
| 11 | Abnormality of alanine metabolism (HP:0010916) | 3.46842253 |
| 12 | Hyperalaninemia (HP:0003348) | 3.46842253 |
| 13 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 3.46842253 |
| 14 | Hepatic necrosis (HP:0002605) | 3.40988248 |
| 15 | Hepatocellular necrosis (HP:0001404) | 3.36136942 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.19907610 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 2.87660241 |
| 18 | Lactic acidosis (HP:0003128) | 2.86479106 |
| 19 | Abnormal number of erythroid precursors (HP:0012131) | 2.86023300 |
| 20 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.81816000 |
| 21 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.81162209 |
| 22 | Renal Fanconi syndrome (HP:0001994) | 2.77691097 |
| 23 | Optic disc pallor (HP:0000543) | 2.77205089 |
| 24 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.73126484 |
| 25 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.73126484 |
| 26 | Lethargy (HP:0001254) | 2.68807147 |
| 27 | Stenosis of the external auditory canal (HP:0000402) | 2.64309374 |
| 28 | Increased intramyocellular lipid droplets (HP:0012240) | 2.63245454 |
| 29 | Central scotoma (HP:0000603) | 2.48221741 |
| 30 | Progressive microcephaly (HP:0000253) | 2.47290269 |
| 31 | Generalized aminoaciduria (HP:0002909) | 2.42258093 |
| 32 | Respiratory failure (HP:0002878) | 2.40028466 |
| 33 | Abnormality of urine glucose concentration (HP:0011016) | 2.39733008 |
| 34 | Glycosuria (HP:0003076) | 2.39733008 |
| 35 | Methylmalonic acidemia (HP:0002912) | 2.39087696 |
| 36 | Exercise intolerance (HP:0003546) | 2.35810511 |
| 37 | Aplastic anemia (HP:0001915) | 2.32242543 |
| 38 | Constricted visual fields (HP:0001133) | 2.31981186 |
| 39 | Colon cancer (HP:0003003) | 2.27691762 |
| 40 | Poor head control (HP:0002421) | 2.27380568 |
| 41 | Respiratory difficulties (HP:0002880) | 2.25968323 |
| 42 | Supernumerary spleens (HP:0009799) | 2.25613450 |
| 43 | Exertional dyspnea (HP:0002875) | 2.24261283 |
| 44 | Leukodystrophy (HP:0002415) | 2.23182790 |
| 45 | Hypothermia (HP:0002045) | 2.17340522 |
| 46 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.17188401 |
| 47 | Elevated erythrocyte sedimentation rate (HP:0003565) | 2.17009428 |
| 48 | Pancreatic cysts (HP:0001737) | 2.16759089 |
| 49 | Posterior subcapsular cataract (HP:0007787) | 2.10208137 |
| 50 | Increased muscle lipid content (HP:0009058) | 2.07522462 |
| 51 | Increased serum pyruvate (HP:0003542) | 2.07102231 |
| 52 | Nausea (HP:0002018) | 2.06961270 |
| 53 | Hypokalemic alkalosis (HP:0001949) | 2.06882960 |
| 54 | Abnormality of serum amino acid levels (HP:0003112) | 2.06007627 |
| 55 | Increased IgM level (HP:0003496) | 2.02159632 |
| 56 | Stomatitis (HP:0010280) | 2.02027651 |
| 57 | Hypoproteinemia (HP:0003075) | 1.99435046 |
| 58 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.99008142 |
| 59 | Hypoplasia of the fovea (HP:0007750) | 1.99008142 |
| 60 | Methylmalonic aciduria (HP:0012120) | 1.98555380 |
| 61 | Abnormality of renal resorption (HP:0011038) | 1.98421940 |
| 62 | Alkalosis (HP:0001948) | 1.97823638 |
| 63 | Molar tooth sign on MRI (HP:0002419) | 1.96352843 |
| 64 | Abnormality of midbrain morphology (HP:0002418) | 1.96352843 |
| 65 | Degeneration of anterior horn cells (HP:0002398) | 1.93525119 |
| 66 | Abnormality of the anterior horn cell (HP:0006802) | 1.93525119 |
| 67 | CNS hypomyelination (HP:0003429) | 1.92260068 |
| 68 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.91763636 |
| 69 | Attenuation of retinal blood vessels (HP:0007843) | 1.90590056 |
| 70 | Abnormality of the fovea (HP:0000493) | 1.89404605 |
| 71 | Pancreatic fibrosis (HP:0100732) | 1.88730929 |
| 72 | Metabolic alkalosis (HP:0200114) | 1.87566916 |
| 73 | Parakeratosis (HP:0001036) | 1.86918911 |
| 74 | Abnormality of the pons (HP:0007361) | 1.86787214 |
| 75 | Congenital stationary night blindness (HP:0007642) | 1.86045043 |
| 76 | Type I transferrin isoform profile (HP:0003642) | 1.85696125 |
| 77 | CNS demyelination (HP:0007305) | 1.82390073 |
| 78 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.81686422 |
| 79 | Hypoglycemic coma (HP:0001325) | 1.80013192 |
| 80 | Abnormal pancreas size (HP:0012094) | 1.79798435 |
| 81 | Neutropenia (HP:0001875) | 1.79543276 |
| 82 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.79397262 |
| 83 | Abnormal protein glycosylation (HP:0012346) | 1.79397262 |
| 84 | Abnormal glycosylation (HP:0012345) | 1.79397262 |
| 85 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.79397262 |
| 86 | Polyuria (HP:0000103) | 1.78199386 |
| 87 | Abnormality of methionine metabolism (HP:0010901) | 1.77041435 |
| 88 | Macrocytic anemia (HP:0001972) | 1.75751815 |
| 89 | Abnormality of T cell physiology (HP:0011840) | 1.75177281 |
| 90 | Abnormality of homocysteine metabolism (HP:0010919) | 1.73824798 |
| 91 | Homocystinuria (HP:0002156) | 1.73824798 |
| 92 | Abnormality of T cells (HP:0002843) | 1.73695487 |
| 93 | Optic neuritis (HP:0100653) | 1.73358679 |
| 94 | Retrobulbar optic neuritis (HP:0100654) | 1.73358679 |
| 95 | Abnormality of T cell number (HP:0011839) | 1.72651458 |
| 96 | Stomach cancer (HP:0012126) | 1.71961055 |
| 97 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.71909272 |
| 98 | X-linked dominant inheritance (HP:0001423) | 1.71654930 |
| 99 | Abnormality of magnesium homeostasis (HP:0004921) | 1.71159351 |
| 100 | Sparse eyelashes (HP:0000653) | 1.71003990 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 5.25899415 |
| 2 | PDK2 | 4.77502661 |
| 3 | TXK | 3.73273579 |
| 4 | BCKDK | 3.40226315 |
| 5 | MST4 | 3.22844587 |
| 6 | EIF2AK1 | 2.99561326 |
| 7 | ADRBK2 | 2.58640707 |
| 8 | MUSK | 2.49094027 |
| 9 | BUB1 | 2.42064809 |
| 10 | VRK1 | 2.28398386 |
| 11 | EIF2AK3 | 2.27809212 |
| 12 | GRK1 | 2.14962139 |
| 13 | SRPK1 | 2.13309288 |
| 14 | ZAK | 2.11867931 |
| 15 | NME2 | 2.08007948 |
| 16 | NME1 | 1.85915361 |
| 17 | TLK1 | 1.84595363 |
| 18 | TIE1 | 1.79538878 |
| 19 | NEK1 | 1.73173089 |
| 20 | NUAK1 | 1.71884567 |
| 21 | TSSK6 | 1.60355685 |
| 22 | PLK3 | 1.51216848 |
| 23 | MKNK1 | 1.37695001 |
| 24 | PASK | 1.36654576 |
| 25 | MAP2K6 | 1.25800987 |
| 26 | STK16 | 1.25422908 |
| 27 | ITK | 1.22081022 |
| 28 | DYRK2 | 1.16490230 |
| 29 | TEC | 1.12543879 |
| 30 | MAP3K12 | 1.11373790 |
| 31 | MAPKAPK5 | 1.02086652 |
| 32 | PBK | 0.98512312 |
| 33 | BMPR1B | 0.98168635 |
| 34 | KDR | 0.92800158 |
| 35 | WNK4 | 0.91949841 |
| 36 | OXSR1 | 0.89327156 |
| 37 | TAF1 | 0.89258157 |
| 38 | FRK | 0.89239832 |
| 39 | TNIK | 0.88986101 |
| 40 | BTK | 0.86902325 |
| 41 | PLK1 | 0.84663471 |
| 42 | MAP3K9 | 0.82581886 |
| 43 | PRKCG | 0.82424839 |
| 44 | BMPR2 | 0.81272627 |
| 45 | GRK5 | 0.80314451 |
| 46 | NLK | 0.75937212 |
| 47 | MAP4K1 | 0.71000831 |
| 48 | MKNK2 | 0.68526242 |
| 49 | PINK1 | 0.67677752 |
| 50 | INSRR | 0.66642460 |
| 51 | ADRBK1 | 0.66609509 |
| 52 | FLT3 | 0.66272174 |
| 53 | STK39 | 0.65284433 |
| 54 | WNK3 | 0.64948266 |
| 55 | PLK4 | 0.64678816 |
| 56 | EIF2AK2 | 0.59905105 |
| 57 | SYK | 0.59645700 |
| 58 | PLK2 | 0.57591722 |
| 59 | FGFR2 | 0.56783830 |
| 60 | RPS6KA5 | 0.56000852 |
| 61 | CSNK2A1 | 0.55986764 |
| 62 | AURKB | 0.54235244 |
| 63 | GRK7 | 0.53329150 |
| 64 | FGFR1 | 0.52137306 |
| 65 | CAMKK2 | 0.51677311 |
| 66 | MYLK | 0.50855878 |
| 67 | PIK3CA | 0.48437933 |
| 68 | PAK3 | 0.48194050 |
| 69 | ILK | 0.47344555 |
| 70 | ATR | 0.46750296 |
| 71 | DAPK1 | 0.46481648 |
| 72 | CCNB1 | 0.45967732 |
| 73 | PRKCI | 0.45552764 |
| 74 | CAMK2A | 0.44882644 |
| 75 | ALK | 0.42842424 |
| 76 | CSNK2A2 | 0.39608195 |
| 77 | TGFBR1 | 0.38512456 |
| 78 | NTRK2 | 0.38163167 |
| 79 | PHKG1 | 0.38150410 |
| 80 | PHKG2 | 0.38150410 |
| 81 | DAPK3 | 0.38104959 |
| 82 | CHEK2 | 0.37655703 |
| 83 | PRKCH | 0.37293478 |
| 84 | TRIM28 | 0.35743151 |
| 85 | PRKCA | 0.35591552 |
| 86 | PRKACA | 0.35013599 |
| 87 | TAOK3 | 0.34142648 |
| 88 | WEE1 | 0.34068727 |
| 89 | PRKCE | 0.32517657 |
| 90 | CDC7 | 0.32372688 |
| 91 | IKBKB | 0.32264065 |
| 92 | CSNK1E | 0.32062713 |
| 93 | ACVR1B | 0.27078112 |
| 94 | PRKCD | 0.27040831 |
| 95 | STK11 | 0.26981105 |
| 96 | PRKCQ | 0.26912502 |
| 97 | OBSCN | 0.25850244 |
| 98 | RIPK4 | 0.25792982 |
| 99 | ABL2 | 0.25497267 |
| 100 | ATM | 0.24823049 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.12814579 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.07249600 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.71689207 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.47729295 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.03420897 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 2.54795598 |
| 7 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.42721064 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.24779126 |
| 9 | RNA polymerase_Homo sapiens_hsa03020 | 2.22105839 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.10432812 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.03008615 |
| 12 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.97481450 |
| 13 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.94563319 |
| 14 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.81822374 |
| 15 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.80579059 |
| 16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.75463848 |
| 17 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.53064854 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.52108940 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.46346610 |
| 20 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.40541404 |
| 21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.39968792 |
| 22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.38107212 |
| 23 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.35278033 |
| 24 | RNA degradation_Homo sapiens_hsa03018 | 1.34068547 |
| 25 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.31391986 |
| 26 | Mismatch repair_Homo sapiens_hsa03430 | 1.30336150 |
| 27 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.27869793 |
| 28 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.27149590 |
| 29 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.25719173 |
| 30 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.22088074 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.21953845 |
| 32 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.19524202 |
| 33 | RNA transport_Homo sapiens_hsa03013 | 1.18383515 |
| 34 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.18317429 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.18315730 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.17982835 |
| 37 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.15790898 |
| 38 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.15495829 |
| 39 | DNA replication_Homo sapiens_hsa03030 | 1.13279416 |
| 40 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.05038913 |
| 41 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.02972480 |
| 42 | Peroxisome_Homo sapiens_hsa04146 | 1.02492097 |
| 43 | Allograft rejection_Homo sapiens_hsa05330 | 1.01299653 |
| 44 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.99894200 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.98357235 |
| 46 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.97761054 |
| 47 | Sulfur relay system_Homo sapiens_hsa04122 | 0.95495496 |
| 48 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.93532797 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.93270409 |
| 50 | Base excision repair_Homo sapiens_hsa03410 | 0.93153231 |
| 51 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.89434765 |
| 52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.84921290 |
| 53 | Spliceosome_Homo sapiens_hsa03040 | 0.81417745 |
| 54 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.81261607 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.81053959 |
| 56 | Phototransduction_Homo sapiens_hsa04744 | 0.80643582 |
| 57 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.76173783 |
| 58 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.76024570 |
| 59 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.70819750 |
| 60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.69614348 |
| 61 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.69002581 |
| 62 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.67634198 |
| 63 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.66082821 |
| 64 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.64009053 |
| 65 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.63436740 |
| 66 | Asthma_Homo sapiens_hsa05310 | 0.62856849 |
| 67 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.60565958 |
| 68 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.60339779 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59785728 |
| 70 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.59543646 |
| 71 | Carbon metabolism_Homo sapiens_hsa01200 | 0.59109811 |
| 72 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.56324860 |
| 73 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.54794903 |
| 74 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.54781240 |
| 75 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.53633473 |
| 76 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52511086 |
| 77 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.52007061 |
| 78 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.51552135 |
| 79 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.48044795 |
| 80 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.47440961 |
| 81 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.47113778 |
| 82 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.46365291 |
| 83 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.46080787 |
| 84 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.45956259 |
| 85 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.44445387 |
| 86 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.43248193 |
| 87 | Retinol metabolism_Homo sapiens_hsa00830 | 0.42837521 |
| 88 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.41034471 |
| 89 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40965830 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.40302711 |
| 91 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.38770138 |
| 92 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36721501 |
| 93 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.34628192 |
| 94 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.34273143 |
| 95 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.33152862 |
| 96 | Cell cycle_Homo sapiens_hsa04110 | 0.32071504 |
| 97 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.31589518 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.31517551 |
| 99 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.28606217 |
| 100 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.26491478 |

