SLC25A5P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.83221878
2proteasome assembly (GO:0043248)6.01540530
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.72275092
4ATP synthesis coupled proton transport (GO:0015986)4.70926873
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.70926873
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.58333714
7regulation of cellular amino acid metabolic process (GO:0006521)4.44833606
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.42573491
9leukotriene biosynthetic process (GO:0019370)4.42315953
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.40152933
11rRNA modification (GO:0000154)4.38853608
12intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.28507300
13signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.28507300
14signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.24839894
15signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.24839894
16signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.24839894
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.22772984
18protein neddylation (GO:0045116)4.05073400
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.04770190
20negative regulation of ligase activity (GO:0051352)4.04770190
21signal transduction involved in DNA integrity checkpoint (GO:0072401)4.04667378
22signal transduction involved in DNA damage checkpoint (GO:0072422)4.04667378
23signal transduction involved in cell cycle checkpoint (GO:0072395)3.98480373
24anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.97012752
25regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.94376026
26cullin deneddylation (GO:0010388)3.93501749
27viral mRNA export from host cell nucleus (GO:0046784)3.86593564
28protein K6-linked ubiquitination (GO:0085020)3.86546127
29protein deneddylation (GO:0000338)3.83038721
30rRNA methylation (GO:0031167)3.81213268
31protein complex biogenesis (GO:0070271)3.80690791
32negative regulation of thymocyte apoptotic process (GO:0070244)3.74543093
33water-soluble vitamin biosynthetic process (GO:0042364)3.73934048
34positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.72140170
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71808465
36histamine secretion (GO:0001821)3.70285719
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.69611231
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.61383528
39NADH dehydrogenase complex assembly (GO:0010257)3.61383528
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61383528
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.61371381
42mitochondrial respiratory chain complex assembly (GO:0033108)3.57873720
43GTP biosynthetic process (GO:0006183)3.55729522
44positive regulation of ligase activity (GO:0051351)3.55599470
45chaperone-mediated protein transport (GO:0072321)3.54430750
46platelet dense granule organization (GO:0060155)3.51618847
47DNA double-strand break processing (GO:0000729)3.48867187
48respiratory chain complex IV assembly (GO:0008535)3.44694312
49respiratory electron transport chain (GO:0022904)3.42570778
50electron transport chain (GO:0022900)3.38357144
51regulation of cellular amine metabolic process (GO:0033238)3.34794783
52cytidine catabolic process (GO:0006216)3.28011612
53cytidine deamination (GO:0009972)3.28011612
54cytidine metabolic process (GO:0046087)3.28011612
55establishment of protein localization to mitochondrial membrane (GO:0090151)3.24564325
56activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.24527067
57positive regulation of cell cycle arrest (GO:0071158)3.22215908
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.20648320
59DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.15416817
60antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12470909
61cytochrome complex assembly (GO:0017004)3.12412142
62regulation of ubiquitin-protein transferase activity (GO:0051438)3.10987966
63ribosome assembly (GO:0042255)3.10690324
64purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.10333989
65response to pheromone (GO:0019236)3.04497794
66regulation of ligase activity (GO:0051340)2.99778221
67histamine transport (GO:0051608)2.98985310
68pseudouridine synthesis (GO:0001522)2.97104921
69UTP biosynthetic process (GO:0006228)2.93266416
70DNA catabolic process, exonucleolytic (GO:0000738)2.92451099
71deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.91639630
72RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91029633
73purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90518844
74regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.88855646
75dopamine transport (GO:0015872)2.87010904
76adenosine metabolic process (GO:0046085)2.86491951
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.83724248
78negative regulation of cell cycle G1/S phase transition (GO:1902807)2.80966280
79negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.80966280
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.74852057
81termination of RNA polymerase III transcription (GO:0006386)2.74852057
82negative regulation of protein ubiquitination (GO:0031397)2.70389617
83protein prenylation (GO:0018342)2.67956549
84prenylation (GO:0097354)2.67956549
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.66655531
86L-fucose catabolic process (GO:0042355)2.66010759
87fucose catabolic process (GO:0019317)2.66010759
88L-fucose metabolic process (GO:0042354)2.66010759
89double-strand break repair via homologous recombination (GO:0000724)2.65842739
90regulation of cell cycle arrest (GO:0071156)2.65511274
91preassembly of GPI anchor in ER membrane (GO:0016254)2.64328812
92recombinational repair (GO:0000725)2.64130550
93regulation of B cell apoptotic process (GO:0002902)2.62573714
94ATP biosynthetic process (GO:0006754)2.60985741
95positive regulation of DNA recombination (GO:0045911)2.60608323
96fatty acid derivative biosynthetic process (GO:1901570)2.60400691
97icosanoid biosynthetic process (GO:0046456)2.60400691
98CTP biosynthetic process (GO:0006241)2.59345796
99CTP metabolic process (GO:0046036)2.59345796
100protein-cofactor linkage (GO:0018065)2.58646572

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.48264939
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21774529
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.13938745
4VDR_22108803_ChIP-Seq_LS180_Human4.08845331
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.95318245
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.83755265
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75069140
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.72286812
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68876330
10VDR_23849224_ChIP-Seq_CD4+_Human2.68733959
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62425739
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.52664129
13ELK1_19687146_ChIP-ChIP_HELA_Human2.49678345
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.30014303
15ZNF274_21170338_ChIP-Seq_K562_Hela2.24857863
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22213547
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21266573
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20030054
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02471754
20EWS_26573619_Chip-Seq_HEK293_Human1.95042021
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.93684614
22E2F7_22180533_ChIP-Seq_HELA_Human1.93096005
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.88870095
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86195521
25FOXP3_21729870_ChIP-Seq_TREG_Human1.82739658
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77496813
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71819035
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66721236
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66164255
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60049761
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58698218
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57079127
33FUS_26573619_Chip-Seq_HEK293_Human1.56562838
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56098424
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46173213
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44816946
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44073477
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43833510
39GBX2_23144817_ChIP-Seq_PC3_Human1.42447513
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41429363
41DCP1A_22483619_ChIP-Seq_HELA_Human1.41357412
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40714495
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40042310
44MYC_18940864_ChIP-ChIP_HL60_Human1.37646957
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.37261312
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34709734
47P300_19829295_ChIP-Seq_ESCs_Human1.34707389
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.34181800
49IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31838284
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.31786723
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.31162901
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31018298
53TP53_22573176_ChIP-Seq_HFKS_Human1.30839527
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.28010724
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27380661
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26793413
57TAF15_26573619_Chip-Seq_HEK293_Human1.24869602
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23706830
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22532556
60ER_23166858_ChIP-Seq_MCF-7_Human1.19336026
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.18983118
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17020204
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16766294
64SOX2_19829295_ChIP-Seq_ESCs_Human1.13214269
65NANOG_19829295_ChIP-Seq_ESCs_Human1.13214269
66MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11503917
67CDX2_22108803_ChIP-Seq_LS180_Human1.11302764
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.11007601
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10521594
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07729206
71AR_20517297_ChIP-Seq_VCAP_Human1.05556433
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.02937896
73NCOR_22424771_ChIP-Seq_293T_Human1.02777935
74CRX_20693478_ChIP-Seq_RETINA_Mouse1.02141746
75GABP_19822575_ChIP-Seq_HepG2_Human1.02091126
76IRF1_19129219_ChIP-ChIP_H3396_Human1.02084526
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01325517
78TTF2_22483619_ChIP-Seq_HELA_Human1.01034355
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00934659
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00892272
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.00892272
82GATA3_26560356_Chip-Seq_TH2_Human1.00288462
83E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99951771
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99003803
85GATA3_26560356_Chip-Seq_TH1_Human0.98361807
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97764539
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.97663106
88THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96230378
89TCF4_22108803_ChIP-Seq_LS180_Human0.94139684
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93638003
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92701290
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92380051
93HTT_18923047_ChIP-ChIP_STHdh_Human0.91732875
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91656224
95SALL1_21062744_ChIP-ChIP_HESCs_Human0.90809287
96ERG_20517297_ChIP-Seq_VCAP_Human0.90251650
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.90036777
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89671595
99SALL4_22934838_ChIP-ChIP_CD34+_Human0.89647919
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89196066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation3.49434104
2MP0002736_abnormal_nociception_after3.41607269
3MP0002102_abnormal_ear_morphology3.06276145
4MP0001835_abnormal_antigen_presentation3.05786030
5MP0003195_calcinosis2.92706003
6MP0009697_abnormal_copulation2.89918070
7MP0001968_abnormal_touch/_nociception2.71930859
8MP0002163_abnormal_gland_morphology2.69377649
9MP0006036_abnormal_mitochondrial_physio2.38938739
10MP0003693_abnormal_embryo_hatching2.28430700
11MP0005075_abnormal_melanosome_morpholog2.28078049
12MP0002095_abnormal_skin_pigmentation2.23921288
13MP0005408_hypopigmentation2.13731871
14MP0003806_abnormal_nucleotide_metabolis2.11840914
15MP0005379_endocrine/exocrine_gland_phen2.11388889
16MP0005671_abnormal_response_to2.07353421
17MP0000015_abnormal_ear_pigmentation1.90079026
18MP0005377_hearing/vestibular/ear_phenot1.85526900
19MP0003878_abnormal_ear_physiology1.85526900
20MP0005171_absent_coat_pigmentation1.83003039
21MP0009333_abnormal_splenocyte_physiolog1.82420217
22MP0010094_abnormal_chromosome_stability1.77330630
23MP0008872_abnormal_physiological_respon1.76547552
24MP0003786_premature_aging1.74600043
25MP0001873_stomach_inflammation1.72846154
26MP0003252_abnormal_bile_duct1.72620520
27MP0002166_altered_tumor_susceptibility1.70618693
28MP0005551_abnormal_eye_electrophysiolog1.67635162
29MP0008058_abnormal_DNA_repair1.66679735
30MP0006035_abnormal_mitochondrial_morpho1.65733513
31MP0003646_muscle_fatigue1.63893230
32MP0003186_abnormal_redox_activity1.61896126
33MP0005084_abnormal_gallbladder_morpholo1.60900211
34MP0004147_increased_porphyrin_level1.59117660
35MP0008875_abnormal_xenobiotic_pharmacok1.51548060
36MP0000427_abnormal_hair_cycle1.50360657
37MP0003567_abnormal_fetal_cardiomyocyte1.48251417
38MP0008057_abnormal_DNA_replication1.47558080
39MP0002148_abnormal_hypersensitivity_rea1.45534817
40MP0002006_tumorigenesis1.42771608
41MP0003111_abnormal_nucleus_morphology1.40201417
42MP0000371_diluted_coat_color1.30037424
43MP0004957_abnormal_blastocyst_morpholog1.29344324
44MP0008995_early_reproductive_senescence1.26949125
45MP0006054_spinal_hemorrhage1.26937380
46MP0005645_abnormal_hypothalamus_physiol1.26671422
47MP0009785_altered_susceptibility_to1.26601702
48MP0000647_abnormal_sebaceous_gland1.26392772
49MP0000685_abnormal_immune_system1.25709067
50MP0004215_abnormal_myocardial_fiber1.25566112
51MP0005253_abnormal_eye_physiology1.23647454
52MP0003718_maternal_effect1.23095396
53MP0000613_abnormal_salivary_gland1.21294143
54MP0004885_abnormal_endolymph1.21084735
55MP0006072_abnormal_retinal_apoptosis1.20148544
56MP0005646_abnormal_pituitary_gland1.19499595
57MP0002138_abnormal_hepatobiliary_system1.11580474
58MP0001800_abnormal_humoral_immune1.07298405
59MP0002751_abnormal_autonomic_nervous1.05243536
60MP0004019_abnormal_vitamin_homeostasis1.05144031
61MP0001905_abnormal_dopamine_level1.04734353
62MP0005085_abnormal_gallbladder_physiolo0.95312576
63MP0001727_abnormal_embryo_implantation0.90784406
64MP0005387_immune_system_phenotype0.90681695
65MP0001790_abnormal_immune_system0.90681695
66MP0004381_abnormal_hair_follicle0.90135823
67MP0002089_abnormal_postnatal_growth/wei0.87461583
68MP0002277_abnormal_respiratory_mucosa0.86584515
69MP0008877_abnormal_DNA_methylation0.84387061
70MP0002282_abnormal_trachea_morphology0.84275141
71MP0002876_abnormal_thyroid_physiology0.83339680
72MP0001119_abnormal_female_reproductive0.81541006
73MP0006292_abnormal_olfactory_placode0.81378364
74MP0000639_abnormal_adrenal_gland0.81302497
75MP0001765_abnormal_ion_homeostasis0.81068678
76MP0002127_abnormal_cardiovascular_syste0.80862870
77MP0002938_white_spotting0.78501871
78MP0002272_abnormal_nervous_system0.78417291
79MP0004145_abnormal_muscle_electrophysio0.76773449
80MP0003638_abnormal_response/metabolism_0.76615844
81MP0005389_reproductive_system_phenotype0.74597271
82MP0004742_abnormal_vestibular_system0.74306917
83MP0000631_abnormal_neuroendocrine_gland0.74184441
84MP0001485_abnormal_pinna_reflex0.73232237
85MP0003183_abnormal_peptide_metabolism0.72932712
86MP0005000_abnormal_immune_tolerance0.71981061
87MP0000689_abnormal_spleen_morphology0.71700568
88MP0009046_muscle_twitch0.71273492
89MP0002160_abnormal_reproductive_system0.70370760
90MP0002723_abnormal_immune_serum0.68688602
91MP0009764_decreased_sensitivity_to0.68229573
92MP0002837_dystrophic_cardiac_calcinosis0.65545640
93MP0002452_abnormal_antigen_presenting0.65387781
94MP0002075_abnormal_coat/hair_pigmentati0.64105789
95MP0000653_abnormal_sex_gland0.63781427
96MP0005670_abnormal_white_adipose0.63549477
97MP0003136_yellow_coat_color0.63403122
98MP0001661_extended_life_span0.63366941
99MP0002822_catalepsy0.63167833
100MP0003077_abnormal_cell_cycle0.62789074

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.54886332
2Increased CSF lactate (HP:0002490)4.04993977
3Acute encephalopathy (HP:0006846)3.96652043
4Mitochondrial inheritance (HP:0001427)3.94284650
5Progressive macrocephaly (HP:0004481)3.89421408
6Abnormal mitochondria in muscle tissue (HP:0008316)3.82182751
7Hepatocellular necrosis (HP:0001404)3.73869429
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.65559448
9Absent/shortened dynein arms (HP:0200106)3.65559448
10Hepatic necrosis (HP:0002605)3.59352171
11Congenital stationary night blindness (HP:0007642)3.28657888
12Severe combined immunodeficiency (HP:0004430)3.27890966
13Thyroiditis (HP:0100646)3.26717744
14Elevated erythrocyte sedimentation rate (HP:0003565)3.13511762
15Aplasia/Hypoplasia of the fovea (HP:0008060)3.09441604
16Hypoplasia of the fovea (HP:0007750)3.09441604
17Panhypogammaglobulinemia (HP:0003139)2.94596445
18Congenital, generalized hypertrichosis (HP:0004540)2.91471211
19Cerebral edema (HP:0002181)2.90972987
20Aplasia/Hypoplasia of the macula (HP:0008059)2.85604074
21Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78510699
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78510699
23Increased hepatocellular lipid droplets (HP:0006565)2.76322384
24Increased serum lactate (HP:0002151)2.75968036
25Renal Fanconi syndrome (HP:0001994)2.73324936
26Abnormality of the prostate (HP:0008775)2.72281269
27B lymphocytopenia (HP:0010976)2.70415252
28IgG deficiency (HP:0004315)2.66458461
29Aplasia/Hypoplasia affecting the retina (HP:0008061)2.66424048
30Pancreatic cysts (HP:0001737)2.65824304
31Generalized aminoaciduria (HP:0002909)2.63805044
32Combined immunodeficiency (HP:0005387)2.61851885
33Abnormality of the fovea (HP:0000493)2.61457814
34Congenital sensorineural hearing impairment (HP:0008527)2.60427983
35Abnormal spermatogenesis (HP:0008669)2.52326437
36Hypothermia (HP:0002045)2.52042183
37Increased serum pyruvate (HP:0003542)2.50525478
38Abnormality of B cell number (HP:0010975)2.44003678
39Molar tooth sign on MRI (HP:0002419)2.41208681
40Abnormality of midbrain morphology (HP:0002418)2.41208681
41Lipid accumulation in hepatocytes (HP:0006561)2.39692010
42Lactic acidosis (HP:0003128)2.33078831
43Azoospermia (HP:0000027)2.29874127
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.27409212
45Stomatitis (HP:0010280)2.26721151
46Respiratory failure (HP:0002878)2.26062075
47True hermaphroditism (HP:0010459)2.25899827
48Submucous cleft hard palate (HP:0000176)2.25360866
49Abnormality of eosinophils (HP:0001879)2.23131111
50Abnormal respiratory motile cilium morphology (HP:0005938)2.20356867
51Abnormal respiratory epithelium morphology (HP:0012253)2.20356867
52Rough bone trabeculation (HP:0100670)2.18411200
53Abnormality of methionine metabolism (HP:0010901)2.18246437
54Progressive inability to walk (HP:0002505)2.17841920
55Abnormality of glycolysis (HP:0004366)2.17626269
56Optic disc pallor (HP:0000543)2.17348580
573-Methylglutaconic aciduria (HP:0003535)2.15083108
58Hypoproteinemia (HP:0003075)2.14345712
59Abnormality of renal resorption (HP:0011038)2.10602772
60Prostate neoplasm (HP:0100787)2.08367168
61Palpitations (HP:0001962)2.08124363
62Adrenal hypoplasia (HP:0000835)2.06154169
63Progressive microcephaly (HP:0000253)2.05844053
64Opisthotonus (HP:0002179)2.03617667
65Eosinophilia (HP:0001880)2.03102913
66Exertional dyspnea (HP:0002875)2.03096988
67Pancreatic fibrosis (HP:0100732)2.02698560
68Agammaglobulinemia (HP:0004432)2.02665022
69Cerebral hypomyelination (HP:0006808)1.99580001
70Lethargy (HP:0001254)1.99309893
71Aplastic anemia (HP:0001915)1.97334366
72Leukodystrophy (HP:0002415)1.94836066
73Nausea (HP:0002018)1.94719897
74Facial diplegia (HP:0001349)1.94624571
75Abnormality of the labia minora (HP:0012880)1.94197563
76Tongue fasciculations (HP:0001308)1.94166035
77Oral leukoplakia (HP:0002745)1.94145748
78Exercise intolerance (HP:0003546)1.93147771
79Abnormal lung lobation (HP:0002101)1.92484286
80Mesangial abnormality (HP:0001966)1.91365083
81Hypomagnesemia (HP:0002917)1.87281567
82Abolished electroretinogram (ERG) (HP:0000550)1.86653344
83Abnormal ciliary motility (HP:0012262)1.85557722
84Symptomatic seizures (HP:0011145)1.81801857
85Constricted visual fields (HP:0001133)1.81145084
86Abnormality of macular pigmentation (HP:0008002)1.79706601
87Supernumerary spleens (HP:0009799)1.78941458
88Chronic otitis media (HP:0000389)1.78111231
89Methylmalonic acidemia (HP:0002912)1.77136244
90Abnormality of urine glucose concentration (HP:0011016)1.76060106
91Glycosuria (HP:0003076)1.76060106
92Autoimmune hemolytic anemia (HP:0001890)1.75959192
93Polydipsia (HP:0001959)1.75609792
94Abnormal drinking behavior (HP:0030082)1.75609792
95Palpebral edema (HP:0100540)1.75484064
96Abnormality of the renal cortex (HP:0011035)1.73455346
97Inability to walk (HP:0002540)1.73380741
98J-shaped sella turcica (HP:0002680)1.71440019
99IgM deficiency (HP:0002850)1.71040915
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70236678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.54711529
2VRK23.50460206
3NUAK13.36108127
4EIF2AK33.19264835
5MST43.10479734
6CCNB12.66564914
7TSSK62.62776455
8MAP3K122.54964435
9EIF2AK12.41829844
10TXK2.25279103
11FRK2.16196748
12NEK12.01472534
13BUB11.92811628
14PDK21.85622794
15NME11.80089230
16WNK41.75052611
17PLK31.74991639
18TNIK1.69860336
19PLK21.66334037
20DAPK11.63188303
21PLK41.60021004
22VRK11.59519127
23TAF11.57091546
24TLK11.39831475
25MAPK131.38347291
26WEE11.32231308
27TEC1.27821780
28MAPKAPK31.23541078
29CSNK1G21.22646493
30CSNK1G31.20834066
31MYLK1.19030430
32GRK11.18976412
33CAMKK21.18848304
34TESK11.16953890
35ADRBK21.16529464
36TAOK31.16258946
37STK391.13814513
38BMPR1B1.13435547
39EIF2AK21.11598957
40GRK51.05824570
41TRIM281.05258068
42ILK1.04539763
43CSNK1A1L1.03470149
44CSNK1G11.02285004
45MAP4K20.97362898
46OXSR10.96998850
47TTK0.94688031
48ITK0.89070770
49PTK2B0.88626837
50STK38L0.87499412
51IRAK10.87293924
52PHKG20.80903342
53PHKG10.80903342
54BRSK20.79114852
55ZAK0.74966657
56MKNK20.74445921
57ERBB30.72026875
58KDR0.71958307
59TIE10.71912229
60WNK30.70952048
61NLK0.65250083
62BMPR20.64294340
63SRPK10.63933605
64SYK0.62325657
65ADRBK10.61977409
66PBK0.61140889
67MAPKAPK50.60132456
68PIK3CG0.59309706
69DYRK20.56524717
70MKNK10.55887519
71BRSK10.55313527
72DAPK30.55025403
73CDK80.54905949
74LIMK10.54282184
75INSRR0.49731076
76BCKDK0.48864623
77PLK10.47008048
78CAMK2A0.46969720
79PINK10.46527826
80IKBKE0.45426693
81ATR0.45042960
82FER0.44487019
83CDC70.42024888
84BCR0.41865028
85IKBKB0.40774727
86NME20.40710507
87SIK30.38903814
88STK100.36523042
89IGF1R0.36269841
90PRKCE0.34449124
91CSNK2A10.34431590
92OBSCN0.33971194
93AURKB0.31777365
94WNK10.31378900
95PRKG10.30366845
96CAMK2D0.29971159
97LYN0.29010542
98RIPK40.28744571
99PAK30.28580980
100PRKCA0.28145545

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.37985435
2Oxidative phosphorylation_Homo sapiens_hsa001903.25397250
3Parkinsons disease_Homo sapiens_hsa050123.07967991
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65312861
5Homologous recombination_Homo sapiens_hsa034402.41860695
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.20264755
7Protein export_Homo sapiens_hsa030602.12686447
8DNA replication_Homo sapiens_hsa030302.01081020
9Alzheimers disease_Homo sapiens_hsa050101.94619314
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.86513325
11Asthma_Homo sapiens_hsa053101.86234131
12Mismatch repair_Homo sapiens_hsa034301.84226384
13Huntingtons disease_Homo sapiens_hsa050161.83132371
14RNA polymerase_Homo sapiens_hsa030201.78566854
15Primary immunodeficiency_Homo sapiens_hsa053401.76952927
16One carbon pool by folate_Homo sapiens_hsa006701.73928325
17Allograft rejection_Homo sapiens_hsa053301.58618966
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51455480
19Ribosome_Homo sapiens_hsa030101.50578089
20Sulfur metabolism_Homo sapiens_hsa009201.49146833
21Non-homologous end-joining_Homo sapiens_hsa034501.44919350
22RNA degradation_Homo sapiens_hsa030181.42677502
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.38524926
24Graft-versus-host disease_Homo sapiens_hsa053321.32794569
25Type I diabetes mellitus_Homo sapiens_hsa049401.31134898
26RNA transport_Homo sapiens_hsa030131.28973766
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28902011
28Autoimmune thyroid disease_Homo sapiens_hsa053201.28583206
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28124113
30Pyrimidine metabolism_Homo sapiens_hsa002401.26916848
31Propanoate metabolism_Homo sapiens_hsa006401.23755387
32Collecting duct acid secretion_Homo sapiens_hsa049661.22943840
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21663160
34Fanconi anemia pathway_Homo sapiens_hsa034601.19785358
35Glutathione metabolism_Homo sapiens_hsa004801.18215463
36Purine metabolism_Homo sapiens_hsa002301.15515906
37Linoleic acid metabolism_Homo sapiens_hsa005911.14588571
38Fatty acid elongation_Homo sapiens_hsa000621.12324560
39Nucleotide excision repair_Homo sapiens_hsa034201.12115772
40Rheumatoid arthritis_Homo sapiens_hsa053231.11953986
41Phototransduction_Homo sapiens_hsa047441.10515312
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07803691
43Antigen processing and presentation_Homo sapiens_hsa046121.04246087
44Cardiac muscle contraction_Homo sapiens_hsa042601.03776716
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01304210
46Selenocompound metabolism_Homo sapiens_hsa004500.99695804
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98960025
48Spliceosome_Homo sapiens_hsa030400.98832492
49Pyruvate metabolism_Homo sapiens_hsa006200.97313390
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95509575
51Arachidonic acid metabolism_Homo sapiens_hsa005900.95206004
52Tryptophan metabolism_Homo sapiens_hsa003800.95005095
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92373697
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86386068
55Basal transcription factors_Homo sapiens_hsa030220.86338363
56Regulation of autophagy_Homo sapiens_hsa041400.85033478
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84543147
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83883746
59Peroxisome_Homo sapiens_hsa041460.83087304
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.82622751
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81593953
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80743811
63Base excision repair_Homo sapiens_hsa034100.79496735
64Nitrogen metabolism_Homo sapiens_hsa009100.73644639
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72104743
66Sulfur relay system_Homo sapiens_hsa041220.70534360
67Ether lipid metabolism_Homo sapiens_hsa005650.70020614
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67749647
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67517834
70Metabolic pathways_Homo sapiens_hsa011000.62685312
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62573883
72Chemical carcinogenesis_Homo sapiens_hsa052040.61258486
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54849744
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54664612
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53471820
76Caffeine metabolism_Homo sapiens_hsa002320.52022813
77Glycerolipid metabolism_Homo sapiens_hsa005610.51901241
78Fat digestion and absorption_Homo sapiens_hsa049750.51645017
79Fatty acid degradation_Homo sapiens_hsa000710.45181431
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44810511
81Folate biosynthesis_Homo sapiens_hsa007900.44693938
82Olfactory transduction_Homo sapiens_hsa047400.41124440
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40066537
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.39320707
85Legionellosis_Homo sapiens_hsa051340.39286160
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38918299
87p53 signaling pathway_Homo sapiens_hsa041150.38093600
88Epstein-Barr virus infection_Homo sapiens_hsa051690.38034537
89beta-Alanine metabolism_Homo sapiens_hsa004100.37991694
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.37500815
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37030473
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.36771428
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34554588
94Cell cycle_Homo sapiens_hsa041100.34489344
95Oocyte meiosis_Homo sapiens_hsa041140.30770867
96Mineral absorption_Homo sapiens_hsa049780.29529551
97Serotonergic synapse_Homo sapiens_hsa047260.27139264
98Retinol metabolism_Homo sapiens_hsa008300.25576266
99Hematopoietic cell lineage_Homo sapiens_hsa046400.23217663
100Morphine addiction_Homo sapiens_hsa050320.22987011

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