SLC25A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.73930980
2ribosomal small subunit assembly (GO:0000028)6.48112959
3ribosomal small subunit biogenesis (GO:0042274)6.28302252
4translational termination (GO:0006415)6.24911674
5translational elongation (GO:0006414)5.66732677
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.37861836
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.27086693
8protein targeting to ER (GO:0045047)5.13559255
9cotranslational protein targeting to membrane (GO:0006613)5.10197985
10* viral life cycle (GO:0019058)5.09657713
11formation of translation preinitiation complex (GO:0001731)4.98406754
12cellular protein complex disassembly (GO:0043624)4.88346401
13establishment of protein localization to endoplasmic reticulum (GO:0072599)4.86669373
14protein localization to endoplasmic reticulum (GO:0070972)4.84052044
15translational initiation (GO:0006413)4.78108729
16protein complex disassembly (GO:0043241)4.60251975
17maturation of SSU-rRNA (GO:0030490)4.32217868
18proline biosynthetic process (GO:0006561)4.30659061
19macromolecular complex disassembly (GO:0032984)4.22205988
20pentose-phosphate shunt (GO:0006098)4.13510136
21regulation of mammary gland epithelial cell proliferation (GO:0033599)4.00004356
22peptidyl-arginine omega-N-methylation (GO:0035247)3.85495456
23negative regulation of erythrocyte differentiation (GO:0045647)3.79755346
24protein targeting to membrane (GO:0006612)3.76831250
25NADPH regeneration (GO:0006740)3.75880856
26DNA unwinding involved in DNA replication (GO:0006268)3.75440934
27ribosomal large subunit biogenesis (GO:0042273)3.70193397
28protein maturation by protein folding (GO:0022417)3.66407625
29COPI coating of Golgi vesicle (GO:0048205)3.64969268
30Golgi transport vesicle coating (GO:0048200)3.64969268
31ribonucleoprotein complex biogenesis (GO:0022613)3.61414282
32glucose catabolic process (GO:0006007)3.55688234
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53969053
34pinocytosis (GO:0006907)3.48862691
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.42856454
36deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.36061668
37regulation of translational fidelity (GO:0006450)3.33150475
38translation (GO:0006412)3.31267462
39mRNA catabolic process (GO:0006402)3.27849565
40GDP-mannose metabolic process (GO:0019673)3.25781419
41histone arginine methylation (GO:0034969)3.25145495
42DNA strand elongation involved in DNA replication (GO:0006271)3.22013180
43negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19804903
44NADH metabolic process (GO:0006734)3.15166118
45DNA strand elongation (GO:0022616)3.13248025
46RNA catabolic process (GO:0006401)3.09260565
47nucleosome disassembly (GO:0006337)3.06538629
48protein-DNA complex disassembly (GO:0032986)3.06538629
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.03175230
503-UTR-mediated mRNA stabilization (GO:0070935)3.02295785
51pentose metabolic process (GO:0019321)3.02010238
52negative regulation of cell size (GO:0045792)2.99801088
53peptidyl-arginine methylation (GO:0018216)2.98696065
54peptidyl-arginine N-methylation (GO:0035246)2.98696065
55spliceosomal tri-snRNP complex assembly (GO:0000244)2.98648699
56establishment of integrated proviral latency (GO:0075713)2.98034316
57negative regulation of B cell apoptotic process (GO:0002903)2.93272840
58purine deoxyribonucleotide catabolic process (GO:0009155)2.87441510
59proline metabolic process (GO:0006560)2.87330516
60ncRNA 3-end processing (GO:0043628)2.86366891
61negative regulation of mRNA processing (GO:0050686)2.84862080
62negative regulation of RNA splicing (GO:0033119)2.84861955
63UV protection (GO:0009650)2.83563903
64deoxyribonucleotide catabolic process (GO:0009264)2.78027916
65deoxyribose phosphate catabolic process (GO:0046386)2.75162251
66establishment of protein localization to membrane (GO:0090150)2.74664920
67intracellular estrogen receptor signaling pathway (GO:0030520)2.74577040
68ribosome biogenesis (GO:0042254)2.74522802
69telomere maintenance via semi-conservative replication (GO:0032201)2.74137379
70cellular response to interleukin-4 (GO:0071353)2.73039132
71apoptotic process involved in morphogenesis (GO:0060561)2.71594368
72establishment of viral latency (GO:0019043)2.69495619
73tricarboxylic acid metabolic process (GO:0072350)2.67551603
74NIK/NF-kappaB signaling (GO:0038061)2.61631876
75negative regulation of mRNA metabolic process (GO:1903312)2.61340209
76activation of MAPKKK activity (GO:0000185)2.61338241
77nucleotide salvage (GO:0043173)2.50156384
78DNA replication initiation (GO:0006270)2.48765611
79retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48461760
80cellular component biogenesis (GO:0044085)2.48420143
81pyrimidine nucleotide catabolic process (GO:0006244)2.48316202
82T cell apoptotic process (GO:0070231)2.47244587
83maternal placenta development (GO:0001893)2.45987797
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.45965732
85viral mRNA export from host cell nucleus (GO:0046784)2.45386790
86oxidative phosphorylation (GO:0006119)2.44769634
87response to interleukin-4 (GO:0070670)2.44311065
88heterochromatin organization (GO:0070828)2.41127008
89positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.40567302
90rRNA transcription (GO:0009303)2.38705014
91trophectodermal cell differentiation (GO:0001829)2.38495600
92cellular hyperosmotic response (GO:0071474)2.37972563
93L-serine metabolic process (GO:0006563)2.36964635
94protein retention in ER lumen (GO:0006621)2.36786872
95regulation of mitochondrial translation (GO:0070129)2.34425354
96nucleobase-containing small molecule interconversion (GO:0015949)2.34193619
97mannose metabolic process (GO:0006013)2.34015124
98regulation of superoxide anion generation (GO:0032928)2.33895710
99mitochondrial fusion (GO:0008053)2.33840827
100base-excision repair (GO:0006284)2.33828082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48843071
2E2F7_22180533_ChIP-Seq_HELA_Human3.16615241
3MYC_18555785_ChIP-Seq_MESCs_Mouse2.91568083
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88452094
5MYC_22102868_ChIP-Seq_BL_Human2.84726754
6VDR_21846776_ChIP-Seq_THP-1_Human2.71302462
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57037177
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34614611
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.29042813
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13450103
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10699086
12LXR_22292898_ChIP-Seq_THP-1_Human2.09622451
13XRN2_22483619_ChIP-Seq_HELA_Human1.98086606
14CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93696660
15ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89762462
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.87614209
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83393938
18ZNF263_19887448_ChIP-Seq_K562_Human1.81585118
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76941992
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76588062
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70527945
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.68885508
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.64999964
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64966564
25RACK7_27058665_Chip-Seq_MCF-7_Human1.64595735
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63660457
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57774870
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57275313
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57154010
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57144054
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.52129711
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49797748
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.48085007
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.47775515
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43980434
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.43755960
37TCF7_22412390_ChIP-Seq_EML_Mouse1.43376824
38CIITA_25753668_ChIP-Seq_RAJI_Human1.39470531
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38864493
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38782548
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38580103
42KDM2B_26808549_Chip-Seq_DND41_Human1.38472272
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37792743
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37751851
45P68_20966046_ChIP-Seq_HELA_Human1.37641413
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.37445112
47VDR_24763502_ChIP-Seq_THP-1_Human1.36701893
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36219580
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33310345
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31073656
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30792532
52UTX_26944678_Chip-Seq_JUKART_Human1.29585646
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28800644
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.27537931
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27335458
56TTF2_22483619_ChIP-Seq_HELA_Human1.25291792
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24260097
58MAF_26560356_Chip-Seq_TH1_Human1.23933214
59* GABP_19822575_ChIP-Seq_HepG2_Human1.23662926
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23113076
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22498858
62MAF_26560356_Chip-Seq_TH2_Human1.21918458
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21167885
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20067811
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.19451700
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18873158
67DCP1A_22483619_ChIP-Seq_HELA_Human1.17350527
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17043649
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16741243
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16230804
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15041599
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14803234
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14636490
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13993641
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13707508
76NCOR1_26117541_ChIP-Seq_K562_Human1.12756497
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12409124
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12099206
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10973240
80KDM5A_27292631_Chip-Seq_BREAST_Human1.10041899
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09886499
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09485426
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09048160
84CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09037445
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08919195
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08508757
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08242524
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07780613
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.07074720
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06539172
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05221134
92ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04239823
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03945550
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03427408
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.03363789
96BCOR_27268052_Chip-Seq_Bcells_Human1.01868000
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01205035
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.00919519
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.00656468
100BCL6_27268052_Chip-Seq_Bcells_Human1.00492873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.52634258
2MP0003693_abnormal_embryo_hatching2.76882471
3MP0009278_abnormal_bone_marrow2.67682594
4MP0005058_abnormal_lysosome_morphology2.61271316
5MP0002396_abnormal_hematopoietic_system2.55774166
6MP0003705_abnormal_hypodermis_morpholog2.52753607
7MP0003111_abnormal_nucleus_morphology2.47155767
8MP0008260_abnormal_autophagy2.45711794
9MP0004957_abnormal_blastocyst_morpholog2.37696971
10MP0005451_abnormal_body_composition2.30106009
11MP0002796_impaired_skin_barrier2.26589552
12MP0009333_abnormal_splenocyte_physiolog2.12510278
13MP0001849_ear_inflammation2.05992850
14MP0004858_abnormal_nervous_system2.05858747
15MP0000490_abnormal_crypts_of2.03290633
16MP0005501_abnormal_skin_physiology1.99031503
17MP0010094_abnormal_chromosome_stability1.90632633
18MP0003077_abnormal_cell_cycle1.85985345
19MP0001730_embryonic_growth_arrest1.83883881
20MP0000678_abnormal_parathyroid_gland1.73164986
21MP0004264_abnormal_extraembryonic_tissu1.65577487
22MP0001545_abnormal_hematopoietic_system1.64288076
23MP0005397_hematopoietic_system_phenotyp1.64288076
24MP0003763_abnormal_thymus_physiology1.64072299
25MP0008932_abnormal_embryonic_tissue1.64029333
26MP0009840_abnormal_foam_cell1.57964293
27MP0000350_abnormal_cell_proliferation1.57755502
28MP0009672_abnormal_birth_weight1.56116588
29MP0005075_abnormal_melanosome_morpholog1.55152006
30MP0010030_abnormal_orbit_morphology1.53520644
31MP0000313_abnormal_cell_death1.44640164
32MP0003436_decreased_susceptibility_to1.42770946
33MP0005257_abnormal_intraocular_pressure1.40689095
34MP0002398_abnormal_bone_marrow1.34003153
35MP0005076_abnormal_cell_differentiation1.33993757
36MP0001873_stomach_inflammation1.33912982
37MP0003806_abnormal_nucleotide_metabolis1.33868600
38MP0005464_abnormal_platelet_physiology1.33725563
39MP0000858_altered_metastatic_potential1.32828491
40MP0002080_prenatal_lethality1.31856448
41MP0004808_abnormal_hematopoietic_stem1.31115433
42MP0003303_peritoneal_inflammation1.30456887
43MP0000703_abnormal_thymus_morphology1.29152831
44MP0003123_paternal_imprinting1.26105651
45MP0008058_abnormal_DNA_repair1.24799022
46MP0004185_abnormal_adipocyte_glucose1.24228031
47MP0002089_abnormal_postnatal_growth/wei1.19044456
48MP0002429_abnormal_blood_cell1.17077547
49MP0001881_abnormal_mammary_gland1.16012856
50MP0002019_abnormal_tumor_incidence1.15121209
51MP0002722_abnormal_immune_system1.13536832
52MP0002249_abnormal_larynx_morphology1.13209495
53MP0001853_heart_inflammation1.11435315
54MP0004381_abnormal_hair_follicle1.10543747
55MP0001672_abnormal_embryogenesis/_devel1.08398804
56MP0005380_embryogenesis_phenotype1.08398804
57MP0003566_abnormal_cell_adhesion1.04585021
58MP0004947_skin_inflammation1.03848081
59MP0000685_abnormal_immune_system1.03708800
60MP0004782_abnormal_surfactant_physiolog1.02885407
61MP0003984_embryonic_growth_retardation1.02462904
62MP0003186_abnormal_redox_activity1.02083572
63MP0003172_abnormal_lysosome_physiology1.00853885
64MP0008007_abnormal_cellular_replicative1.00834263
65MP0002132_abnormal_respiratory_system0.99220793
66MP0000477_abnormal_intestine_morphology0.98699158
67MP0003191_abnormal_cellular_cholesterol0.98292462
68MP0000716_abnormal_immune_system0.97715225
69MP0005666_abnormal_adipose_tissue0.97288595
70MP0000689_abnormal_spleen_morphology0.97145674
71MP0005670_abnormal_white_adipose0.96716100
72MP0003183_abnormal_peptide_metabolism0.96435873
73MP0002088_abnormal_embryonic_growth/wei0.94753028
74MP0002420_abnormal_adaptive_immunity0.94156483
75MP0001819_abnormal_immune_cell0.94142998
76MP0005025_abnormal_response_to0.93753068
77MP0005000_abnormal_immune_tolerance0.93687605
78MP0009931_abnormal_skin_appearance0.90999633
79MP0000681_abnormal_thyroid_gland0.90145551
80MP0000465_gastrointestinal_hemorrhage0.90051664
81MP0001697_abnormal_embryo_size0.89696157
82MP0002085_abnormal_embryonic_tissue0.89588522
83MP0002098_abnormal_vibrissa_morphology0.87844367
84MP0003786_premature_aging0.87161688
85MP0008438_abnormal_cutaneous_collagen0.86736967
86MP0005621_abnormal_cell_physiology0.85726621
87MP0010155_abnormal_intestine_physiology0.81866321
88MP0006036_abnormal_mitochondrial_physio0.80155277
89MP0001800_abnormal_humoral_immune0.80000596
90MP0002086_abnormal_extraembryonic_tissu0.79759754
91MP0003866_abnormal_defecation0.79659747
92MP0003453_abnormal_keratinocyte_physiol0.79217448
93MP0002452_abnormal_antigen_presenting0.78184986
94MP0005384_cellular_phenotype0.77178106
95MP0000537_abnormal_urethra_morphology0.76329429
96MP0005375_adipose_tissue_phenotype0.75714396
97MP0004233_abnormal_muscle_weight0.75062940
98MP0000358_abnormal_cell_content/0.73833494
99MP0003315_abnormal_perineum_morphology0.73305134
100MP0002723_abnormal_immune_serum0.71898447

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.04929809
2Abnormality of cells of the erythroid lineage (HP:0012130)4.01664101
3Agammaglobulinemia (HP:0004432)3.63838304
4Abnormal number of erythroid precursors (HP:0012131)3.63427034
5Cellulitis (HP:0100658)3.13966407
6Abnormal gallbladder physiology (HP:0012438)3.04384726
7Cholecystitis (HP:0001082)3.04384726
8Microvesicular hepatic steatosis (HP:0001414)3.03982436
9Hyperacusis (HP:0010780)2.94957476
10Multiple enchondromatosis (HP:0005701)2.83730269
11Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83598934
12Vertebral compression fractures (HP:0002953)2.79515578
13Thrombocytosis (HP:0001894)2.71491860
14Macrocytic anemia (HP:0001972)2.68788708
15Abnormality of reticulocytes (HP:0004312)2.64689098
16Long palpebral fissure (HP:0000637)2.57973656
17Premature skin wrinkling (HP:0100678)2.55489003
18Pallor (HP:0000980)2.54449936
19Hypertensive crisis (HP:0100735)2.52198593
20Trismus (HP:0000211)2.51658104
21Ragged-red muscle fibers (HP:0003200)2.47286405
22Centrally nucleated skeletal muscle fibers (HP:0003687)2.45367327
23Broad distal phalanx of finger (HP:0009836)2.37317358
24Seborrheic dermatitis (HP:0001051)2.36264819
25Petechiae (HP:0000967)2.36173194
26Increased IgE level (HP:0003212)2.36005070
27Rough bone trabeculation (HP:0100670)2.30590430
28Protrusio acetabuli (HP:0003179)2.25302111
29Progressive muscle weakness (HP:0003323)2.19968833
30Polygenic inheritance (HP:0010982)2.19465177
31Colitis (HP:0002583)2.18893020
32Gastrointestinal stroma tumor (HP:0100723)2.16193823
33Biconcave vertebral bodies (HP:0004586)2.13471802
34Panhypogammaglobulinemia (HP:0003139)2.10141879
35Disproportionate tall stature (HP:0001519)2.08989841
36Abnormality of the thoracic spine (HP:0100711)2.00996116
37Gastrointestinal inflammation (HP:0004386)1.99783611
38Reticulocytosis (HP:0001923)1.98259288
39Recurrent viral infections (HP:0004429)1.97419622
40Abnormality of the umbilical cord (HP:0010881)1.96674932
41Aplastic anemia (HP:0001915)1.96150006
42Growth hormone excess (HP:0000845)1.95365577
43Thoracic kyphosis (HP:0002942)1.92602251
44Abnormality of small intestinal villus morphology (HP:0011472)1.92551716
45Villous atrophy (HP:0011473)1.92551716
46Partial duplication of the phalanx of hand (HP:0009999)1.92551297
47Partial duplication of thumb phalanx (HP:0009944)1.89109640
48Insomnia (HP:0100785)1.87906419
49Deep palmar crease (HP:0006191)1.84580773
50Hepatosplenomegaly (HP:0001433)1.84410849
51Obstructive lung disease (HP:0006536)1.83585576
52Chronic obstructive pulmonary disease (HP:0006510)1.83585576
53Abnormal umbilical cord blood vessels (HP:0011403)1.81850317
54Single umbilical artery (HP:0001195)1.81850317
55Abnormality of the fetal cardiovascular system (HP:0010948)1.81850317
56Gastrointestinal dysmotility (HP:0002579)1.81673280
57Thin bony cortex (HP:0002753)1.80734598
58Abnormal trabecular bone morphology (HP:0100671)1.80692580
59Achilles tendon contracture (HP:0001771)1.78398012
60Aplasia/Hypoplasia of the thymus (HP:0010515)1.78394414
61Verrucae (HP:0200043)1.76557860
62Papilloma (HP:0012740)1.76557860
63Lymphangioma (HP:0100764)1.75509907
64Asymmetry of the thorax (HP:0001555)1.75208691
65Cerebral palsy (HP:0100021)1.71467952
66Testicular atrophy (HP:0000029)1.70025985
67Purpura (HP:0000979)1.67779459
68Meningitis (HP:0001287)1.66539843
69Premature rupture of membranes (HP:0001788)1.66429919
70Premature ovarian failure (HP:0008209)1.65401384
71Eczematoid dermatitis (HP:0000976)1.64349058
72J-shaped sella turcica (HP:0002680)1.59184517
73Athetosis (HP:0002305)1.59017525
74Increased neuronal autofluorescent lipopigment (HP:0002074)1.57940964
75Lymphopenia (HP:0001888)1.57455605
76Abnormality of glycolysis (HP:0004366)1.57335427
77High anterior hairline (HP:0009890)1.57018222
78Annular pancreas (HP:0001734)1.56431244
79Flattened epiphyses (HP:0003071)1.56103535
80Truncus arteriosus (HP:0001660)1.55908600
81Emphysema (HP:0002097)1.55404330
82Increased cerebral lipofuscin (HP:0011813)1.54946284
83Overriding aorta (HP:0002623)1.54566891
84Generalized amyotrophy (HP:0003700)1.54339990
85Pointed chin (HP:0000307)1.53894027
86Myopathic facies (HP:0002058)1.53222166
87Easy fatigability (HP:0003388)1.52869513
88Hyperparathyroidism (HP:0000843)1.51573390
89Abnormality of cells of the lymphoid lineage (HP:0012140)1.50984703
90Stridor (HP:0010307)1.49253924
91Recurrent lower respiratory tract infections (HP:0002783)1.48420985
92Delayed cranial suture closure (HP:0000270)1.47971970
93Mediastinal lymphadenopathy (HP:0100721)1.47854544
94Breech presentation (HP:0001623)1.47503958
95Delayed epiphyseal ossification (HP:0002663)1.47136717
96Inflammation of the large intestine (HP:0002037)1.46973246
97Wide cranial sutures (HP:0010537)1.46797357
98Hyperthyroidism (HP:0000836)1.46557323
99Cholelithiasis (HP:0001081)1.45456595
100Distal lower limb muscle weakness (HP:0009053)1.45191021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.47116608
2SMG13.99979877
3TRIB33.80108302
4VRK23.51785337
5TESK23.03449309
6PRPF4B2.93530683
7EEF2K2.88579199
8ERN12.60006972
9MAP3K102.09501394
10MAP4K12.07797685
11TESK11.92804227
12KDR1.90086885
13BCKDK1.86690523
14SIK11.76547470
15LRRK21.74902612
16PASK1.69384355
17ICK1.69000018
18ARAF1.53264332
19CDK191.53082446
20PIM21.51794417
21MAP3K111.50611961
22PKN21.49551055
23IRAK31.45715387
24RPS6KB21.38762099
25TAOK21.36366969
26FGFR41.36296050
27CDK121.27024168
28SCYL21.26522448
29CDK71.18286277
30BUB11.17300300
31TBK11.07281084
32EPHA20.97434906
33MAP3K80.97241370
34CDK40.94324741
35RIPK40.92312042
36PAK40.92070372
37CDC70.90184381
38ILK0.90146276
39DAPK10.89837914
40BRAF0.86442631
41PRKD30.85827786
42MAP2K20.85232818
43AURKA0.74862218
44GRK60.74685625
45MAP2K30.73850218
46PDK20.73601259
47RPS6KL10.72641547
48RPS6KC10.72641547
49PTK60.69864216
50MTOR0.68967394
51TTK0.68764849
52STK160.65831501
53RIPK10.64764616
54PRKD20.63778868
55RPS6KA20.62532170
56DAPK30.59971088
57MAPK110.59169049
58KIT0.58345147
59MAP3K130.55603361
60SRPK10.55522420
61MAP3K10.54577884
62PDPK10.51674433
63ATR0.51554710
64MATK0.51427052
65PBK0.51294730
66SIK30.51225164
67CSF1R0.51220891
68BMX0.50392173
69ABL20.50208782
70BTK0.50168511
71FES0.49978528
72AKT20.49754392
73IRAK40.49550853
74RPS6KA60.48862085
75PAK20.48531813
76PAK10.48154287
77TAF10.48033538
78TYK20.48020453
79CDK11A0.46648806
80CHEK10.46603417
81LMTK20.45914673
82CLK10.45264298
83MARK20.45231410
84JAK30.45111066
85PDGFRA0.43655593
86ALK0.43045363
87CHEK20.41851015
88HIPK20.41648998
89MAPKAPK20.40890744
90AURKB0.40464721
91CDK20.39157514
92LIMK10.39089322
93FLT30.38940515
94RPS6KA10.38731707
95ZAP700.38044064
96NME10.37255475
97MAPKAPK30.36277384
98IRAK20.36234410
99CDK90.34784755
100IKBKE0.33342078

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.11518495
2DNA replication_Homo sapiens_hsa030303.72095666
3Base excision repair_Homo sapiens_hsa034103.32293688
4Pentose phosphate pathway_Homo sapiens_hsa000302.57319540
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53662848
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.48946036
7Biosynthesis of amino acids_Homo sapiens_hsa012302.31059168
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.21339052
9Sulfur relay system_Homo sapiens_hsa041222.16566618
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14333905
11Spliceosome_Homo sapiens_hsa030402.03499398
12Other glycan degradation_Homo sapiens_hsa005111.99027988
13Fructose and mannose metabolism_Homo sapiens_hsa000511.85977318
14Carbon metabolism_Homo sapiens_hsa012001.81729088
15Mismatch repair_Homo sapiens_hsa034301.77016250
16Acute myeloid leukemia_Homo sapiens_hsa052211.75767187
17Primary immunodeficiency_Homo sapiens_hsa053401.66622676
18Galactose metabolism_Homo sapiens_hsa000521.62839775
19Pyrimidine metabolism_Homo sapiens_hsa002401.48849088
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.42392789
21Proteasome_Homo sapiens_hsa030501.36943910
22Chronic myeloid leukemia_Homo sapiens_hsa052201.33765765
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31559217
24Notch signaling pathway_Homo sapiens_hsa043301.29051359
25RNA transport_Homo sapiens_hsa030131.26061753
26B cell receptor signaling pathway_Homo sapiens_hsa046621.22157422
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20394346
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18296167
29Fatty acid elongation_Homo sapiens_hsa000621.13233301
30Bladder cancer_Homo sapiens_hsa052191.11767274
31Thyroid cancer_Homo sapiens_hsa052161.09795373
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06636631
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02344497
34RNA polymerase_Homo sapiens_hsa030201.00970013
35Epstein-Barr virus infection_Homo sapiens_hsa051691.00503989
36Nucleotide excision repair_Homo sapiens_hsa034200.99955228
37Non-small cell lung cancer_Homo sapiens_hsa052230.99189537
38mRNA surveillance pathway_Homo sapiens_hsa030150.96538593
39Cell cycle_Homo sapiens_hsa041100.95554242
40Glutathione metabolism_Homo sapiens_hsa004800.95248768
41One carbon pool by folate_Homo sapiens_hsa006700.92376976
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92243881
43Shigellosis_Homo sapiens_hsa051310.92167173
44Herpes simplex infection_Homo sapiens_hsa051680.91901962
45Non-homologous end-joining_Homo sapiens_hsa034500.91433964
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91386824
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89658431
48Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86517669
49* HTLV-I infection_Homo sapiens_hsa051660.81120108
50Pancreatic cancer_Homo sapiens_hsa052120.75916745
51Apoptosis_Homo sapiens_hsa042100.75795961
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.75735717
53N-Glycan biosynthesis_Homo sapiens_hsa005100.75495020
54Viral myocarditis_Homo sapiens_hsa054160.74576507
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70916799
56Vibrio cholerae infection_Homo sapiens_hsa051100.68039116
57Endometrial cancer_Homo sapiens_hsa052130.67183040
58Homologous recombination_Homo sapiens_hsa034400.65715575
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.64768171
60Colorectal cancer_Homo sapiens_hsa052100.64120887
61Pyruvate metabolism_Homo sapiens_hsa006200.63237639
62Hepatitis B_Homo sapiens_hsa051610.62598822
63Antigen processing and presentation_Homo sapiens_hsa046120.62528928
64VEGF signaling pathway_Homo sapiens_hsa043700.62367971
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61018063
66Allograft rejection_Homo sapiens_hsa053300.59325486
67Leishmaniasis_Homo sapiens_hsa051400.59168872
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55913678
69Purine metabolism_Homo sapiens_hsa002300.54795989
70Viral carcinogenesis_Homo sapiens_hsa052030.54586412
71mTOR signaling pathway_Homo sapiens_hsa041500.51999808
72Autoimmune thyroid disease_Homo sapiens_hsa053200.49291041
73Endocytosis_Homo sapiens_hsa041440.48919852
74Asthma_Homo sapiens_hsa053100.48862307
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.47295465
76HIF-1 signaling pathway_Homo sapiens_hsa040660.47162514
77Folate biosynthesis_Homo sapiens_hsa007900.46614102
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.45029744
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44627395
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44200251
81Lysine degradation_Homo sapiens_hsa003100.44181087
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43609052
83Hepatitis C_Homo sapiens_hsa051600.42880957
84* Influenza A_Homo sapiens_hsa051640.42746004
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41625581
86Small cell lung cancer_Homo sapiens_hsa052220.41461015
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40577598
88Lysosome_Homo sapiens_hsa041420.39310107
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.37732493
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35081919
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.34843616
92Insulin signaling pathway_Homo sapiens_hsa049100.34519448
93Prostate cancer_Homo sapiens_hsa052150.33656415
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31896361
95Vitamin digestion and absorption_Homo sapiens_hsa049770.31861241
96AMPK signaling pathway_Homo sapiens_hsa041520.31394545
97p53 signaling pathway_Homo sapiens_hsa041150.31156391
98Graft-versus-host disease_Homo sapiens_hsa053320.29603101
99Parkinsons disease_Homo sapiens_hsa050120.29253465
100Prion diseases_Homo sapiens_hsa050200.28562940

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