SLC25A6P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleoside transport (GO:0015858)9.65814129
2interferon-gamma production (GO:0032609)7.50370431
3nucleotide-sugar biosynthetic process (GO:0009226)6.96396518
4cofactor transport (GO:0051181)6.31698932
5modified amino acid transport (GO:0072337)6.08355050
6peroxisome fission (GO:0016559)5.94484224
7coenzyme A biosynthetic process (GO:0015937)5.59400909
8pantothenate metabolic process (GO:0015939)5.54018661
9reproduction (GO:0000003)5.35883082
10regulation of mitochondrial membrane potential (GO:0051881)5.28116693
11cellular response to estradiol stimulus (GO:0071392)5.01285637
12exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.96266805
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.71820498
14ATP synthesis coupled proton transport (GO:0015986)4.71820498
15sulfur compound transport (GO:0072348)4.68516576
16urinary tract smooth muscle contraction (GO:0014848)4.62135776
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.61791445
18negative regulation of cAMP-mediated signaling (GO:0043951)4.58161571
19DNA deamination (GO:0045006)4.48567074
20short-chain fatty acid metabolic process (GO:0046459)4.42535019
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.33695275
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.33695275
23carbohydrate derivative transport (GO:1901264)4.33477080
24nucleotide-sugar metabolic process (GO:0009225)4.21012272
25regulation of receptor binding (GO:1900120)4.16241493
26monoubiquitinated protein deubiquitination (GO:0035520)4.04584680
27positive regulation of protein kinase C signaling (GO:0090037)4.00022826
28positive regulation of transcription regulatory region DNA binding (GO:2000679)3.88549316
29positive regulation of icosanoid secretion (GO:0032305)3.85066177
30lateral ventricle development (GO:0021670)3.81873665
31outer ear morphogenesis (GO:0042473)3.79400095
32negative regulation of execution phase of apoptosis (GO:1900118)3.77254502
33histone H2A acetylation (GO:0043968)3.75044735
34regulation of proton transport (GO:0010155)3.64910398
35regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.63950712
36regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.63950712
37ribosomal small subunit biogenesis (GO:0042274)3.54984994
38positive regulation of fatty acid transport (GO:2000193)3.54290776
39purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.52587281
40mitochondrion morphogenesis (GO:0070584)3.50246652
41aerobic respiration (GO:0009060)3.49620843
42ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.45139619
43nucleoside bisphosphate biosynthetic process (GO:0033866)3.45139619
44purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.45139619
45homocysteine metabolic process (GO:0050667)3.34740664
46establishment of protein localization to peroxisome (GO:0072663)3.34113264
47protein localization to peroxisome (GO:0072662)3.34113264
48protein targeting to peroxisome (GO:0006625)3.34113264
49endoderm formation (GO:0001706)3.30988384
50regulation of histone phosphorylation (GO:0033127)3.29380745
51water-soluble vitamin biosynthetic process (GO:0042364)3.28908530
52translational elongation (GO:0006414)3.28893877
53cobalamin metabolic process (GO:0009235)3.27590465
54dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.27426469
55response to muscle activity (GO:0014850)3.26926184
56histone H3-K36 demethylation (GO:0070544)3.25109343
57innate immune response in mucosa (GO:0002227)3.22656461
58viral transcription (GO:0019083)3.19957208
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.19821146
60cellular response to estrogen stimulus (GO:0071391)3.18718143
61coenzyme A metabolic process (GO:0015936)3.17834545
62alpha-beta T cell differentiation involved in immune response (GO:0002293)3.17784780
63alpha-beta T cell activation involved in immune response (GO:0002287)3.17784780
64T cell differentiation involved in immune response (GO:0002292)3.17784780
65cytidine deamination (GO:0009972)3.12163398
66cytidine metabolic process (GO:0046087)3.12163398
67cytidine catabolic process (GO:0006216)3.12163398
68translational termination (GO:0006415)3.11231170
69protein deneddylation (GO:0000338)3.10359945
70myoblast differentiation (GO:0045445)3.09213545
71response to pheromone (GO:0019236)3.08852085
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03751227
73ribosomal small subunit assembly (GO:0000028)3.03460162
74antibacterial humoral response (GO:0019731)2.99977456
75peroxisomal transport (GO:0043574)2.99547345
76regulation of icosanoid secretion (GO:0032303)2.98791613
77alternative mRNA splicing, via spliceosome (GO:0000380)2.97016945
78positive regulation of myoblast differentiation (GO:0045663)2.94142049
79meiotic chromosome segregation (GO:0045132)2.88807115
80cerebral cortex neuron differentiation (GO:0021895)2.86463046
81response to misfolded protein (GO:0051788)2.79866626
82positive regulation of defense response to virus by host (GO:0002230)2.79123482
83nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.78142951
84striated muscle atrophy (GO:0014891)2.75419269
85antimicrobial humoral response (GO:0019730)2.74651280
86oligosaccharide catabolic process (GO:0009313)2.73723108
87viral protein processing (GO:0019082)2.73562359
88regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73202324
89regulation of neurotransmitter uptake (GO:0051580)2.71576495
90mucosal immune response (GO:0002385)2.70506862
91response to inactivity (GO:0014854)2.69476353
92endocardial cushion morphogenesis (GO:0003203)2.69385213
93cellular component biogenesis (GO:0044085)2.68280133
94amino acid transmembrane transport (GO:0003333)2.67931761
95ribosomal large subunit biogenesis (GO:0042273)2.64361116
96GMP metabolic process (GO:0046037)2.62786940
97GDP-mannose metabolic process (GO:0019673)15.3436441
98mannose metabolic process (GO:0006013)15.0990818
99chaperone-mediated protein transport (GO:0072321)12.1746423
100nucleoside transmembrane transport (GO:1901642)11.7777120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse9.91730449
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.25058010
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.62688814
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.81206629
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30566784
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.84763455
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69006392
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54042558
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.49797772
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.37842766
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.25187585
12ZNF274_21170338_ChIP-Seq_K562_Hela2.21715884
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08283684
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.00776926
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.98536979
16GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.90803565
17ETS1_20019798_ChIP-Seq_JURKAT_Human1.89617338
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81934789
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76043530
20SRY_22984422_ChIP-ChIP_TESTIS_Rat1.75586399
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.69964022
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.69964022
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.69964022
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.69741354
25IGF1R_20145208_ChIP-Seq_DFB_Human1.65276003
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63449360
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58365031
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57348046
29GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.56352563
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.53977534
31KDM5A_27292631_Chip-Seq_BREAST_Human1.48892748
32GATA6_21074721_ChIP-Seq_CACO-2_Human1.46938444
33PHF8_20622853_ChIP-Seq_HELA_Human1.46062498
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45729441
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.44242026
36CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.41816250
37RBPJ_21746931_ChIP-Seq_IB4_Human1.41047665
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.40510943
39VDR_22108803_ChIP-Seq_LS180_Human1.37350061
40HTT_18923047_ChIP-ChIP_STHdh_Human1.36737785
41PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.36514866
42BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36321518
43ETV1_20927104_ChIP-Seq_GIST48_Human1.33157806
44ELK1_19687146_ChIP-ChIP_HELA_Human1.31905286
45NFYB_21822215_ChIP-Seq_K562_Human1.31362032
46NFYA_21822215_ChIP-Seq_K562_Human1.30145132
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29948136
48HNFA_21074721_ChIP-Seq_CACO-2_Human1.24836639
49EGR1_19032775_ChIP-ChIP_M12_Human1.23502077
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23139924
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22935142
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21456384
53VDR_23849224_ChIP-Seq_CD4+_Human1.19860835
54FOXH1_21741376_ChIP-Seq_ESCs_Human1.19472756
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18812868
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16365742
57MYC_19829295_ChIP-Seq_ESCs_Human1.16191487
58IRF1_19129219_ChIP-ChIP_H3396_Human1.15610671
59NANOG_20526341_ChIP-Seq_ESCs_Human1.15587970
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13911150
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13584429
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13156856
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12952341
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11025505
65CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10360815
66TBL1_22424771_ChIP-Seq_293T_Human1.06418198
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.06033123
68SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.05269369
69FUS_26573619_Chip-Seq_HEK293_Human1.04288993
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.03393563
71FOXP3_21729870_ChIP-Seq_TREG_Human1.03106107
72SA1_27219007_Chip-Seq_Bcells_Human1.00945008
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98781252
74PRDM14_20953172_ChIP-Seq_ESCs_Human0.96263443
75CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95910964
76ELF5_23300383_ChIP-Seq_T47D_Human0.95841815
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95813905
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94468860
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93526439
80RNF2_27304074_Chip-Seq_NSC_Mouse0.93055613
81AR_20517297_ChIP-Seq_VCAP_Human0.91101240
82CDX2_22108803_ChIP-Seq_LS180_Human0.90816894
83NCOR_22424771_ChIP-Seq_293T_Human0.89996611
84SOX2_21211035_ChIP-Seq_LN229_Human0.88764033
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88063111
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85831355
87GATA3_21878914_ChIP-Seq_MCF-7_Human0.84869255
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.83612794
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81984825
90E2F1_20622854_ChIP-Seq_HELA_Human0.81672941
91E2F4_17652178_ChIP-ChIP_JURKAT_Human0.81251221
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.80632547
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80632547
94NANOG_16153702_ChIP-ChIP_HESCs_Human0.80492146
95RUNX_20019798_ChIP-Seq_JUKART_Human0.79571905
96STAT1_20625510_ChIP-Seq_HELA_Human0.78884893
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78143527
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77932225
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77104871
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76461118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex7.71717759
2MP0006072_abnormal_retinal_apoptosis4.49300332
3MP0009379_abnormal_foot_pigmentation4.21489097
4MP0003646_muscle_fatigue3.72085408
5MP0004043_abnormal_pH_regulation3.34730430
6MP0001727_abnormal_embryo_implantation3.06858270
7MP0006082_CNS_inflammation2.89006187
8MP0005671_abnormal_response_to2.55305495
9MP0001529_abnormal_vocalization2.53088673
10MP0001873_stomach_inflammation2.51282391
11MP0008260_abnormal_autophagy2.46919233
12MP0001790_abnormal_immune_system2.17753359
13MP0005387_immune_system_phenotype2.17753359
14MP0002822_catalepsy2.02661322
15MP0004270_analgesia1.70051959
16MP0008872_abnormal_physiological_respon1.68010319
17MP0003890_abnormal_embryonic-extraembry1.65521918
18MP0008875_abnormal_xenobiotic_pharmacok1.65216916
19MP0004133_heterotaxia1.65209242
20MP0000015_abnormal_ear_pigmentation1.65191827
21MP0005464_abnormal_platelet_physiology1.59938181
22MP0001986_abnormal_taste_sensitivity1.59775570
23MP0002277_abnormal_respiratory_mucosa1.46409703
24MP0003878_abnormal_ear_physiology1.45856183
25MP0005377_hearing/vestibular/ear_phenot1.45856183
26MP0005174_abnormal_tail_pigmentation1.37795561
27MP0005409_darkened_coat_color1.36971058
28MP0005253_abnormal_eye_physiology1.31814110
29MP0003567_abnormal_fetal_cardiomyocyte1.29429899
30MP0001666_abnormal_nutrient_absorption1.27757555
31MP0001542_abnormal_bone_strength1.26116076
32MP0002102_abnormal_ear_morphology1.22252404
33MP0004264_abnormal_extraembryonic_tissu1.21853372
34MP0004858_abnormal_nervous_system1.20739993
35MP0005167_abnormal_blood-brain_barrier1.19909292
36MP0001881_abnormal_mammary_gland1.19507742
37MP0010386_abnormal_urinary_bladder1.19179961
38MP0001905_abnormal_dopamine_level1.18384502
39MP0002138_abnormal_hepatobiliary_system1.16221826
40MP0002160_abnormal_reproductive_system1.16218795
41MP0009764_decreased_sensitivity_to1.16050479
42MP0009333_abnormal_splenocyte_physiolog1.15713882
43MP0001485_abnormal_pinna_reflex1.14233897
44MP0005645_abnormal_hypothalamus_physiol1.10470057
45MP0002127_abnormal_cardiovascular_syste1.10202998
46MP0002139_abnormal_hepatobiliary_system1.09199279
47MP0008877_abnormal_DNA_methylation1.08347362
48MP0010155_abnormal_intestine_physiology1.07362626
49MP0002837_dystrophic_cardiac_calcinosis1.06377268
50MP0003195_calcinosis1.04035475
51MP0005360_urolithiasis1.03497959
52MP0003879_abnormal_hair_cell1.03266505
53MP0001663_abnormal_digestive_system1.02427397
54MP0000678_abnormal_parathyroid_gland1.00779184
55MP0002971_abnormal_brown_adipose0.98750992
56MP0009250_abnormal_appendicular_skeleto0.97789917
57MP0006035_abnormal_mitochondrial_morpho0.95059098
58MP0005389_reproductive_system_phenotype0.95003344
59MP0001501_abnormal_sleep_pattern0.94888149
60MP0002295_abnormal_pulmonary_circulatio0.89351423
61MP0008775_abnormal_heart_ventricle0.86861566
62MP0002234_abnormal_pharynx_morphology0.86598188
63MP0003718_maternal_effect0.84906435
64MP0002177_abnormal_outer_ear0.84846317
65MP0002735_abnormal_chemical_nociception0.84415126
66MP0005503_abnormal_tendon_morphology0.84020314
67MP0001968_abnormal_touch/_nociception0.83771951
68MP0003283_abnormal_digestive_organ0.82043179
69MP0005084_abnormal_gallbladder_morpholo0.81459196
70MP0005220_abnormal_exocrine_pancreas0.80288988
71MP0005000_abnormal_immune_tolerance0.79959827
72MP0005448_abnormal_energy_balance0.79692732
73MP0001835_abnormal_antigen_presentation0.78357731
74MP0001765_abnormal_ion_homeostasis0.78231014
75MP0000579_abnormal_nail_morphology0.77620605
76MP0008873_increased_physiological_sensi0.77041603
77MP0009765_abnormal_xenobiotic_induced0.76473841
78MP0002148_abnormal_hypersensitivity_rea0.75822280
79MP0002095_abnormal_skin_pigmentation0.74346085
80MP0004215_abnormal_myocardial_fiber0.74082143
81MP0005195_abnormal_posterior_eye0.73450171
82MP0005085_abnormal_gallbladder_physiolo0.73111475
83MP0002876_abnormal_thyroid_physiology0.72682908
84MP0004782_abnormal_surfactant_physiolog0.71998640
85MP0004885_abnormal_endolymph0.69987732
86MP0003693_abnormal_embryo_hatching0.69623376
87MP0002736_abnormal_nociception_after0.69532163
88MP0004142_abnormal_muscle_tone0.68532812
89MP0002796_impaired_skin_barrier0.65071564
90MP0005385_cardiovascular_system_phenoty0.65054900
91MP0001544_abnormal_cardiovascular_syste0.65054900
92MP0005381_digestive/alimentary_phenotyp0.64742332
93MP0002734_abnormal_mechanical_nocicepti0.63959467
94MP0005386_behavior/neurological_phenoty0.63744614
95MP0004924_abnormal_behavior0.63744614
96MP0005551_abnormal_eye_electrophysiolog0.63618270
97MP0000343_altered_response_to0.63362752
98MP0009785_altered_susceptibility_to0.63096698
99MP0002210_abnormal_sex_determination0.62300661
100MP0002098_abnormal_vibrissa_morphology0.61417268

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)9.54681868
2Hypobetalipoproteinemia (HP:0003563)7.47662630
3Acanthocytosis (HP:0001927)6.66930619
4Neurodegeneration (HP:0002180)6.42835160
5Akinesia (HP:0002304)6.28427811
6Patent foramen ovale (HP:0001655)5.45262745
7Dyskinesia (HP:0100660)5.14438606
8Methylmalonic acidemia (HP:0002912)4.90199158
9Abnormality of the phalanges of the 2nd finger (HP:0009541)4.84937449
10Tubulointerstitial nephritis (HP:0001970)4.32745715
11Diminished movement (HP:0002374)4.15235042
12Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.09459130
13Dysphonia (HP:0001618)3.91496847
14Decreased muscle mass (HP:0003199)3.65625288
15Delayed CNS myelination (HP:0002188)3.64992812
16Abnormality of the vitamin B12 metabolism (HP:0004341)3.61688857
17Methylmalonic aciduria (HP:0012120)3.60105396
18Broad distal phalanx of finger (HP:0009836)3.53947595
19Hyperglycinemia (HP:0002154)3.41914378
20Brushfield spots (HP:0001088)3.40250995
21Abnormality of vitamin B metabolism (HP:0004340)3.38263346
22Abnormality of the basal ganglia (HP:0002134)3.26493620
23Long nose (HP:0003189)3.26419983
24Agitation (HP:0000713)3.20658661
25Abnormality of the pons (HP:0007361)3.11847612
26Craniofacial dystonia (HP:0012179)3.11444259
27Hypolipoproteinemia (HP:0010981)3.08800561
28Abnormality of the 2nd finger (HP:0004100)3.07274073
29Focal dystonia (HP:0004373)2.92112132
30Congenital glaucoma (HP:0001087)2.82671390
31Amblyopia (HP:0000646)2.81853294
32Ketoacidosis (HP:0001993)2.80491629
33Hypoplasia of the pons (HP:0012110)2.80221168
34Poikilocytosis (HP:0004447)2.78007910
35Restlessness (HP:0000711)2.77120855
36Partial duplication of the phalanx of hand (HP:0009999)2.72682989
37Progressive muscle weakness (HP:0003323)2.69307291
38Abnormality of fatty-acid metabolism (HP:0004359)2.63193859
39CNS demyelination (HP:0007305)2.60856838
40Microretrognathia (HP:0000308)2.58701404
41Carpal bone hypoplasia (HP:0001498)2.58273588
42Stenosis of the external auditory canal (HP:0000402)2.58180118
43Delayed closure of the anterior fontanelle (HP:0001476)2.56890655
44Hemiplegia (HP:0002301)2.54926896
45Impaired smooth pursuit (HP:0007772)2.51155160
46Large eyes (HP:0001090)2.48924996
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45670693
48Abnormality of alanine metabolism (HP:0010916)2.43301130
49Hyperalaninemia (HP:0003348)2.43301130
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43301130
51Congenital sensorineural hearing impairment (HP:0008527)2.36981559
52Abnormality of vitamin metabolism (HP:0100508)2.35018154
53EMG: neuropathic changes (HP:0003445)2.32700885
54Hepatic necrosis (HP:0002605)2.32571976
55Renal tubular dysfunction (HP:0000124)2.29610274
56Abnormality of glycolipid metabolism (HP:0010969)2.26641855
57Abnormality of liposaccharide metabolism (HP:0010968)2.26641855
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.26641855
59Buphthalmos (HP:0000557)2.23092300
60Morphological abnormality of the pyramidal tract (HP:0002062)2.22629355
61Clumsiness (HP:0002312)2.22523631
62Abnormality of serum amino acid levels (HP:0003112)2.22409266
63Congenital stationary night blindness (HP:0007642)2.17823474
64Coronal craniosynostosis (HP:0004440)2.16320253
65Elevated erythrocyte sedimentation rate (HP:0003565)2.12627776
66Macrocytic anemia (HP:0001972)2.12573352
67Decreased circulating renin level (HP:0003351)2.09560606
68Agnosia (HP:0010524)2.07758434
69Bradykinesia (HP:0002067)2.07434371
70Neurofibrillary tangles (HP:0002185)2.06842483
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06371852
72Dicarboxylic aciduria (HP:0003215)2.06371852
73Hypoproteinemia (HP:0003075)2.06124424
74Ketosis (HP:0001946)2.03842924
75Orchitis (HP:0100796)2.03551904
76Hepatocellular necrosis (HP:0001404)2.03454093
77Abnormality of the parietal bone (HP:0002696)2.02961974
78Aplasia/hypoplasia of the uterus (HP:0008684)2.02728287
79Parakeratosis (HP:0001036)2.01809587
80Choreoathetosis (HP:0001266)2.01420549
81Abnormality of cells of the erythroid lineage (HP:0012130)2.00714680
82Poor suck (HP:0002033)2.00558712
83Increased CSF lactate (HP:0002490)1.99786711
84Rapidly progressive (HP:0003678)1.95441514
85Impulsivity (HP:0100710)1.94832265
86Turricephaly (HP:0000262)1.93508982
87Bicuspid aortic valve (HP:0001647)1.88959376
88Abnormality of serine family amino acid metabolism (HP:0010894)1.86630717
89Abnormality of glycine metabolism (HP:0010895)1.86630717
90Chorioretinal atrophy (HP:0000533)1.85848840
91Tubulointerstitial abnormality (HP:0001969)1.84880791
92Generalized aminoaciduria (HP:0002909)1.82663399
93Cholelithiasis (HP:0001081)1.79220229
94Dyschromatopsia (HP:0007641)1.78629648
95Abnormal gallbladder morphology (HP:0012437)1.78162114
96Hypoglycemic coma (HP:0001325)1.77383779
97Hyperbilirubinemia (HP:0002904)1.76544235
98Delayed cranial suture closure (HP:0000270)1.76252425
99Abnormality of ocular smooth pursuit (HP:0000617)1.75879108
100Gliosis (HP:0002171)1.75654441

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.27333445
2PDK26.19547222
3MAP2K63.82167457
4TIE13.20198099
5PASK2.97440187
6MAP4K22.47625983
7TXK2.01459508
8FRK1.91762439
9GRK11.91518592
10VRK21.89692581
11AKT21.87634864
12MAP3K61.85650742
13STK381.75829846
14MST41.66917741
15SRPK11.63941282
16NUAK11.63457487
17PBK1.56858156
18PRKD21.52434338
19ADRBK21.52260035
20LCK1.37279761
21ZAK1.34593054
22PRKG21.33830825
23WNK31.29293019
24PKN11.25809594
25VRK11.18281517
26TGFBR11.18090844
27TLK11.13493670
28WNK41.12304985
29MAP2K31.01656474
30INSRR0.98710281
31TEC0.94324730
32ROCK20.92329547
33TESK20.91820624
34SYK0.87816049
35NTRK30.87201883
36IRAK20.86167286
37PRKCH0.85023627
38ADRBK10.83814549
39ABL20.79499854
40TBK10.79388245
41PDK10.76417111
42BMPR1B0.75315635
43STK390.75094601
44FES0.71947571
45PIK3CG0.70651776
46ERBB40.70400993
47PDPK10.70334128
48STK160.69415662
49PRKCQ0.66815935
50PIM10.65576365
51CSF1R0.63238575
52YES10.63173423
53OBSCN0.60247839
54PRKCA0.60187838
55PLK30.58944444
56MAP4K10.58506932
57CAMK2A0.56260120
58NME10.55114112
59ZAP700.54730288
60PRKCD0.54709765
61STK30.54568754
62NEK20.53012489
63PLK40.52599102
64MAP3K50.52234407
65MYLK0.51819671
66STK38L0.50759102
67PRKCG0.50464176
68CAMK2D0.50305613
69MAP2K40.50122206
70CSNK2A10.48227153
71RPS6KB10.47512530
72PRKCE0.47406128
73MAP2K20.46506125
74OXSR10.45684711
75GRK50.44976071
76MAP2K10.44063412
77LIMK10.43034870
78EIF2AK30.42832851
79BRAF0.41877708
80ITK0.41707236
81CCNB10.39438838
82INSR0.39366015
83TAOK30.39241874
84PRKACA0.39007241
85EGFR0.38221863
86IGF1R0.37218244
87KDR0.36113981
88MATK0.35828846
89TSSK60.35242051
90CSNK1G30.35212547
91ROCK10.34894130
92MUSK0.34865431
93CSNK1G10.34498212
94FYN0.33636394
95ACVR1B0.33112213
96PIK3CA0.33002692
97IRAK10.31930647
98RPS6KB20.31888253
99MAP3K120.31581932
100KIT0.31380761

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.18427249
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.30689429
3Ribosome_Homo sapiens_hsa030104.25936797
4Fructose and mannose metabolism_Homo sapiens_hsa000514.21568794
5Linoleic acid metabolism_Homo sapiens_hsa005912.48734901
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.35176863
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29249221
8Allograft rejection_Homo sapiens_hsa053302.29165172
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.18370666
10Autoimmune thyroid disease_Homo sapiens_hsa053202.16417375
11RNA degradation_Homo sapiens_hsa030182.15732530
12Proteasome_Homo sapiens_hsa030502.02548951
13Regulation of autophagy_Homo sapiens_hsa041401.99049982
14Asthma_Homo sapiens_hsa053101.95839823
15Oxidative phosphorylation_Homo sapiens_hsa001901.83660247
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.73502458
17Propanoate metabolism_Homo sapiens_hsa006401.68280766
18Fat digestion and absorption_Homo sapiens_hsa049751.60951094
19Parkinsons disease_Homo sapiens_hsa050121.59227830
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58046855
21Selenocompound metabolism_Homo sapiens_hsa004501.48194308
22Type I diabetes mellitus_Homo sapiens_hsa049401.42227085
23Arachidonic acid metabolism_Homo sapiens_hsa005901.38226940
24Phototransduction_Homo sapiens_hsa047441.37138415
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34452538
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26400754
27Graft-versus-host disease_Homo sapiens_hsa053321.26352275
28Caffeine metabolism_Homo sapiens_hsa002321.25097662
29Vitamin digestion and absorption_Homo sapiens_hsa049771.24366584
30Tryptophan metabolism_Homo sapiens_hsa003801.20739488
31Ether lipid metabolism_Homo sapiens_hsa005651.20424022
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18477089
33Renin-angiotensin system_Homo sapiens_hsa046141.17395085
34Peroxisome_Homo sapiens_hsa041461.07232047
35RNA polymerase_Homo sapiens_hsa030201.03037674
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00268852
37Nitrogen metabolism_Homo sapiens_hsa009100.99879505
38Alzheimers disease_Homo sapiens_hsa050100.98347350
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.91466632
40Collecting duct acid secretion_Homo sapiens_hsa049660.86732029
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82439649
42Steroid hormone biosynthesis_Homo sapiens_hsa001400.82353608
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79446415
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78734351
45Retinol metabolism_Homo sapiens_hsa008300.78058357
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73865136
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73431422
48Cardiac muscle contraction_Homo sapiens_hsa042600.73019065
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72901135
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70882556
51Insulin secretion_Homo sapiens_hsa049110.70349916
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68272116
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68182401
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67900470
55Chemical carcinogenesis_Homo sapiens_hsa052040.67712156
56Hematopoietic cell lineage_Homo sapiens_hsa046400.67293681
57Huntingtons disease_Homo sapiens_hsa050160.62323723
58Glutathione metabolism_Homo sapiens_hsa004800.61635261
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59463019
60Pyruvate metabolism_Homo sapiens_hsa006200.58755181
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58346283
62Metabolic pathways_Homo sapiens_hsa011000.56683793
63Renin secretion_Homo sapiens_hsa049240.56129348
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55921378
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.55658483
66Protein export_Homo sapiens_hsa030600.54145021
67Butanoate metabolism_Homo sapiens_hsa006500.52954950
68Purine metabolism_Homo sapiens_hsa002300.52536259
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52015442
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.51330890
71T cell receptor signaling pathway_Homo sapiens_hsa046600.48236736
72Rheumatoid arthritis_Homo sapiens_hsa053230.47739804
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45628435
74Mismatch repair_Homo sapiens_hsa034300.44235536
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.42527768
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41041659
77Thyroid hormone synthesis_Homo sapiens_hsa049180.39859105
78Histidine metabolism_Homo sapiens_hsa003400.38376203
79Glycerolipid metabolism_Homo sapiens_hsa005610.37277588
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33666421
81Mineral absorption_Homo sapiens_hsa049780.33497931
82Olfactory transduction_Homo sapiens_hsa047400.33234154
83Pancreatic secretion_Homo sapiens_hsa049720.33055204
84Taste transduction_Homo sapiens_hsa047420.32714494
85Basal transcription factors_Homo sapiens_hsa030220.32414883
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30800273
87Protein digestion and absorption_Homo sapiens_hsa049740.29289476
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26918611
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26669412
90Vitamin B6 metabolism_Homo sapiens_hsa007500.22938082
91Systemic lupus erythematosus_Homo sapiens_hsa053220.22757205
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.22203591
93Serotonergic synapse_Homo sapiens_hsa047260.21800685
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21099607
95Non-homologous end-joining_Homo sapiens_hsa034500.20732911
96Salivary secretion_Homo sapiens_hsa049700.20253688
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.19961491
98Ovarian steroidogenesis_Homo sapiens_hsa049130.19880864
99Homologous recombination_Homo sapiens_hsa034400.17810458
100Fatty acid degradation_Homo sapiens_hsa000710.17331988

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