ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleoside transport (GO:0015858)	9.65814129
2	interferon-gamma production (GO:0032609)	7.50370431
3	nucleotide-sugar biosynthetic process (GO:0009226)	6.96396518
4	cofactor transport (GO:0051181)	6.31698932
5	modified amino acid transport (GO:0072337)	6.08355050
6	peroxisome fission (GO:0016559)	5.94484224
7	coenzyme A biosynthetic process (GO:0015937)	5.59400909
8	pantothenate metabolic process (GO:0015939)	5.54018661
9	reproduction (GO:0000003)	5.35883082
10	regulation of mitochondrial membrane potential (GO:0051881)	5.28116693
11	cellular response to estradiol stimulus (GO:0071392)	5.01285637
12	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	4.96266805
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.71820498
14	ATP synthesis coupled proton transport (GO:0015986)	4.71820498
15	sulfur compound transport (GO:0072348)	4.68516576
16	urinary tract smooth muscle contraction (GO:0014848)	4.62135776
17	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	4.61791445
18	negative regulation of cAMP-mediated signaling (GO:0043951)	4.58161571
19	DNA deamination (GO:0045006)	4.48567074
20	short-chain fatty acid metabolic process (GO:0046459)	4.42535019
21	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.33695275
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.33695275
23	carbohydrate derivative transport (GO:1901264)	4.33477080
24	nucleotide-sugar metabolic process (GO:0009225)	4.21012272
25	regulation of receptor binding (GO:1900120)	4.16241493
26	monoubiquitinated protein deubiquitination (GO:0035520)	4.04584680
27	positive regulation of protein kinase C signaling (GO:0090037)	4.00022826
28	positive regulation of transcription regulatory region DNA binding (GO:2000679)	3.88549316
29	positive regulation of icosanoid secretion (GO:0032305)	3.85066177
30	lateral ventricle development (GO:0021670)	3.81873665
31	outer ear morphogenesis (GO:0042473)	3.79400095
32	negative regulation of execution phase of apoptosis (GO:1900118)	3.77254502
33	histone H2A acetylation (GO:0043968)	3.75044735
34	regulation of proton transport (GO:0010155)	3.64910398
35	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.63950712
36	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.63950712
37	ribosomal small subunit biogenesis (GO:0042274)	3.54984994
38	positive regulation of fatty acid transport (GO:2000193)	3.54290776
39	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.52587281
40	mitochondrion morphogenesis (GO:0070584)	3.50246652
41	aerobic respiration (GO:0009060)	3.49620843
42	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.45139619
43	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.45139619
44	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.45139619
45	homocysteine metabolic process (GO:0050667)	3.34740664
46	protein targeting to peroxisome (GO:0006625)	3.34113264
47	establishment of protein localization to peroxisome (GO:0072663)	3.34113264
48	protein localization to peroxisome (GO:0072662)	3.34113264
49	endoderm formation (GO:0001706)	3.30988384
50	regulation of histone phosphorylation (GO:0033127)	3.29380745
51	water-soluble vitamin biosynthetic process (GO:0042364)	3.28908530
52	translational elongation (GO:0006414)	3.28893877
53	cobalamin metabolic process (GO:0009235)	3.27590465
54	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.27426469
55	response to muscle activity (GO:0014850)	3.26926184
56	histone H3-K36 demethylation (GO:0070544)	3.25109343
57	innate immune response in mucosa (GO:0002227)	3.22656461
58	viral transcription (GO:0019083)	3.19957208
59	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.19821146
60	cellular response to estrogen stimulus (GO:0071391)	3.18718143
61	coenzyme A metabolic process (GO:0015936)	3.17834545
62	T cell differentiation involved in immune response (GO:0002292)	3.17784780
63	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.17784780
64	alpha-beta T cell activation involved in immune response (GO:0002287)	3.17784780
65	cytidine deamination (GO:0009972)	3.12163398
66	cytidine metabolic process (GO:0046087)	3.12163398
67	cytidine catabolic process (GO:0006216)	3.12163398
68	translational termination (GO:0006415)	3.11231170
69	protein deneddylation (GO:0000338)	3.10359945
70	myoblast differentiation (GO:0045445)	3.09213545
71	response to pheromone (GO:0019236)	3.08852085
72	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.03751227
73	ribosomal small subunit assembly (GO:0000028)	3.03460162
74	antibacterial humoral response (GO:0019731)	2.99977456
75	peroxisomal transport (GO:0043574)	2.99547345
76	regulation of icosanoid secretion (GO:0032303)	2.98791613
77	alternative mRNA splicing, via spliceosome (GO:0000380)	2.97016945
78	positive regulation of myoblast differentiation (GO:0045663)	2.94142049
79	meiotic chromosome segregation (GO:0045132)	2.88807115
80	cerebral cortex neuron differentiation (GO:0021895)	2.86463046
81	response to misfolded protein (GO:0051788)	2.79866626
82	positive regulation of defense response to virus by host (GO:0002230)	2.79123482
83	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)	2.78142951
84	striated muscle atrophy (GO:0014891)	2.75419269
85	antimicrobial humoral response (GO:0019730)	2.74651280
86	oligosaccharide catabolic process (GO:0009313)	2.73723108
87	viral protein processing (GO:0019082)	2.73562359
88	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.73202324
89	regulation of neurotransmitter uptake (GO:0051580)	2.71576495
90	mucosal immune response (GO:0002385)	2.70506862
91	response to inactivity (GO:0014854)	2.69476353
92	endocardial cushion morphogenesis (GO:0003203)	2.69385213
93	cellular component biogenesis (GO:0044085)	2.68280133
94	amino acid transmembrane transport (GO:0003333)	2.67931761
95	ribosomal large subunit biogenesis (GO:0042273)	2.64361116
96	GMP metabolic process (GO:0046037)	2.62786940
97	GDP-mannose metabolic process (GO:0019673)	15.3436441
98	mannose metabolic process (GO:0006013)	15.0990818
99	chaperone-mediated protein transport (GO:0072321)	12.1746423
100	nucleoside transmembrane transport (GO:1901642)	11.7777120

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	9.91730449
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.25058010
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.62688814
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.81206629
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.30566784
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84763455
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.69006392
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.54042558
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.49797772
10	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.37842766
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.25187585
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.21715884
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.08283684
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.00776926
15	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.98536979
16	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.90803565
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.89617338
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81934789
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.76043530
20	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.75586399
21	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.69964022
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.69964022
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.69964022
24	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.69741354
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65276003
26	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.63449360
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.58365031
28	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.57348046
29	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.56352563
30	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.53977534
31	KDM5A_27292631_Chip-Seq_BREAST_Human	1.48892748
32	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.46938444
33	PHF8_20622853_ChIP-Seq_HELA_Human	1.46062498
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45729441
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.44242026
36	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.41816250
37	RBPJ_21746931_ChIP-Seq_IB4_Human	1.41047665
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.40510943
39	VDR_22108803_ChIP-Seq_LS180_Human	1.37350061
40	HTT_18923047_ChIP-ChIP_STHdh_Human	1.36737785
41	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.36514866
42	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.36321518
43	ETV1_20927104_ChIP-Seq_GIST48_Human	1.33157806
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.31905286
45	NFYB_21822215_ChIP-Seq_K562_Human	1.31362032
46	NFYA_21822215_ChIP-Seq_K562_Human	1.30145132
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29948136
48	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.24836639
49	EGR1_19032775_ChIP-ChIP_M12_Human	1.23502077
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.23139924
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22935142
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21456384
53	VDR_23849224_ChIP-Seq_CD4+_Human	1.19860835
54	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.19472756
55	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.18812868
56	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.16365742
57	MYC_19829295_ChIP-Seq_ESCs_Human	1.16191487
58	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15610671
59	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15587970
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.13911150
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13584429
62	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.13156856
63	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.12952341
64	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.11025505
65	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.10360815
66	TBL1_22424771_ChIP-Seq_293T_Human	1.06418198
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06033123
68	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	1.05269369
69	FUS_26573619_Chip-Seq_HEK293_Human	1.04288993
70	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.03393563
71	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03106107
72	SA1_27219007_Chip-Seq_Bcells_Human	1.00945008
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98781252
74	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96263443
75	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.95910964
76	ELF5_23300383_ChIP-Seq_T47D_Human	0.95841815
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.95813905
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94468860
79	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.93526439
80	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93055613
81	AR_20517297_ChIP-Seq_VCAP_Human	0.91101240
82	CDX2_22108803_ChIP-Seq_LS180_Human	0.90816894
83	NCOR_22424771_ChIP-Seq_293T_Human	0.89996611
84	SOX2_21211035_ChIP-Seq_LN229_Human	0.88764033
85	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88063111
86	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85831355
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84869255
88	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.83612794
89	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.81984825
90	E2F1_20622854_ChIP-Seq_HELA_Human	0.81672941
91	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.81251221
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.80632547
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.80632547
94	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.80492146
95	RUNX_20019798_ChIP-Seq_JUKART_Human	0.79571905
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.78884893
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.78143527
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.77932225
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.77104871
100	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.76461118

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002638_abnormal_pupillary_reflex	7.71717759
2	MP0006072_abnormal_retinal_apoptosis	4.49300332
3	MP0009379_abnormal_foot_pigmentation	4.21489097
4	MP0003646_muscle_fatigue	3.72085408
5	MP0004043_abnormal_pH_regulation	3.34730430
6	MP0001727_abnormal_embryo_implantation	3.06858270
7	MP0006082_CNS_inflammation	2.89006187
8	MP0005671_abnormal_response_to	2.55305495
9	MP0001529_abnormal_vocalization	2.53088673
10	MP0001873_stomach_inflammation	2.51282391
11	MP0008260_abnormal_autophagy	2.46919233
12	MP0005387_immune_system_phenotype	2.17753359
13	MP0001790_abnormal_immune_system	2.17753359
14	MP0002822_catalepsy	2.02661322
15	MP0004270_analgesia	1.70051959
16	MP0008872_abnormal_physiological_respon	1.68010319
17	MP0003890_abnormal_embryonic-extraembry	1.65521918
18	MP0008875_abnormal_xenobiotic_pharmacok	1.65216916
19	MP0004133_heterotaxia	1.65209242
20	MP0000015_abnormal_ear_pigmentation	1.65191827
21	MP0005464_abnormal_platelet_physiology	1.59938181
22	MP0001986_abnormal_taste_sensitivity	1.59775570
23	MP0002277_abnormal_respiratory_mucosa	1.46409703
24	MP0005377_hearing/vestibular/ear_phenot	1.45856183
25	MP0003878_abnormal_ear_physiology	1.45856183
26	MP0005174_abnormal_tail_pigmentation	1.37795561
27	MP0005409_darkened_coat_color	1.36971058
28	MP0005253_abnormal_eye_physiology	1.31814110
29	MP0003567_abnormal_fetal_cardiomyocyte	1.29429899
30	MP0001666_abnormal_nutrient_absorption	1.27757555
31	MP0001542_abnormal_bone_strength	1.26116076
32	MP0002102_abnormal_ear_morphology	1.22252404
33	MP0004264_abnormal_extraembryonic_tissu	1.21853372
34	MP0004858_abnormal_nervous_system	1.20739993
35	MP0005167_abnormal_blood-brain_barrier	1.19909292
36	MP0001881_abnormal_mammary_gland	1.19507742
37	MP0010386_abnormal_urinary_bladder	1.19179961
38	MP0001905_abnormal_dopamine_level	1.18384502
39	MP0002138_abnormal_hepatobiliary_system	1.16221826
40	MP0002160_abnormal_reproductive_system	1.16218795
41	MP0009764_decreased_sensitivity_to	1.16050479
42	MP0009333_abnormal_splenocyte_physiolog	1.15713882
43	MP0001485_abnormal_pinna_reflex	1.14233897
44	MP0005645_abnormal_hypothalamus_physiol	1.10470057
45	MP0002127_abnormal_cardiovascular_syste	1.10202998
46	MP0002139_abnormal_hepatobiliary_system	1.09199279
47	MP0008877_abnormal_DNA_methylation	1.08347362
48	MP0010155_abnormal_intestine_physiology	1.07362626
49	MP0002837_dystrophic_cardiac_calcinosis	1.06377268
50	MP0003195_calcinosis	1.04035475
51	MP0005360_urolithiasis	1.03497959
52	MP0003879_abnormal_hair_cell	1.03266505
53	MP0001663_abnormal_digestive_system	1.02427397
54	MP0000678_abnormal_parathyroid_gland	1.00779184
55	MP0002971_abnormal_brown_adipose	0.98750992
56	MP0009250_abnormal_appendicular_skeleto	0.97789917
57	MP0006035_abnormal_mitochondrial_morpho	0.95059098
58	MP0005389_reproductive_system_phenotype	0.95003344
59	MP0001501_abnormal_sleep_pattern	0.94888149
60	MP0002295_abnormal_pulmonary_circulatio	0.89351423
61	MP0008775_abnormal_heart_ventricle	0.86861566
62	MP0002234_abnormal_pharynx_morphology	0.86598188
63	MP0003718_maternal_effect	0.84906435
64	MP0002177_abnormal_outer_ear	0.84846317
65	MP0002735_abnormal_chemical_nociception	0.84415126
66	MP0005503_abnormal_tendon_morphology	0.84020314
67	MP0001968_abnormal_touch/_nociception	0.83771951
68	MP0003283_abnormal_digestive_organ	0.82043179
69	MP0005084_abnormal_gallbladder_morpholo	0.81459196
70	MP0005220_abnormal_exocrine_pancreas	0.80288988
71	MP0005000_abnormal_immune_tolerance	0.79959827
72	MP0005448_abnormal_energy_balance	0.79692732
73	MP0001835_abnormal_antigen_presentation	0.78357731
74	MP0001765_abnormal_ion_homeostasis	0.78231014
75	MP0000579_abnormal_nail_morphology	0.77620605
76	MP0008873_increased_physiological_sensi	0.77041603
77	MP0009765_abnormal_xenobiotic_induced	0.76473841
78	MP0002148_abnormal_hypersensitivity_rea	0.75822280
79	MP0002095_abnormal_skin_pigmentation	0.74346085
80	MP0004215_abnormal_myocardial_fiber	0.74082143
81	MP0005195_abnormal_posterior_eye	0.73450171
82	MP0005085_abnormal_gallbladder_physiolo	0.73111475
83	MP0002876_abnormal_thyroid_physiology	0.72682908
84	MP0004782_abnormal_surfactant_physiolog	0.71998640
85	MP0004885_abnormal_endolymph	0.69987732
86	MP0003693_abnormal_embryo_hatching	0.69623376
87	MP0002736_abnormal_nociception_after	0.69532163
88	MP0004142_abnormal_muscle_tone	0.68532812
89	MP0002796_impaired_skin_barrier	0.65071564
90	MP0001544_abnormal_cardiovascular_syste	0.65054900
91	MP0005385_cardiovascular_system_phenoty	0.65054900
92	MP0005381_digestive/alimentary_phenotyp	0.64742332
93	MP0002734_abnormal_mechanical_nocicepti	0.63959467
94	MP0004924_abnormal_behavior	0.63744614
95	MP0005386_behavior/neurological_phenoty	0.63744614
96	MP0005551_abnormal_eye_electrophysiolog	0.63618270
97	MP0000343_altered_response_to	0.63362752
98	MP0009785_altered_susceptibility_to	0.63096698
99	MP0002210_abnormal_sex_determination	0.62300661
100	MP0002098_abnormal_vibrissa_morphology	0.61417268

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Global brain atrophy (HP:0002283)	9.54681868
2	Hypobetalipoproteinemia (HP:0003563)	7.47662630
3	Acanthocytosis (HP:0001927)	6.66930619
4	Neurodegeneration (HP:0002180)	6.42835160
5	Akinesia (HP:0002304)	6.28427811
6	Patent foramen ovale (HP:0001655)	5.45262745
7	Dyskinesia (HP:0100660)	5.14438606
8	Methylmalonic acidemia (HP:0002912)	4.90199158
9	Abnormality of the phalanges of the 2nd finger (HP:0009541)	4.84937449
10	Tubulointerstitial nephritis (HP:0001970)	4.32745715
11	Diminished movement (HP:0002374)	4.15235042
12	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	4.09459130
13	Dysphonia (HP:0001618)	3.91496847
14	Decreased muscle mass (HP:0003199)	3.65625288
15	Delayed CNS myelination (HP:0002188)	3.64992812
16	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.61688857
17	Methylmalonic aciduria (HP:0012120)	3.60105396
18	Broad distal phalanx of finger (HP:0009836)	3.53947595
19	Hyperglycinemia (HP:0002154)	3.41914378
20	Brushfield spots (HP:0001088)	3.40250995
21	Abnormality of vitamin B metabolism (HP:0004340)	3.38263346
22	Abnormality of the basal ganglia (HP:0002134)	3.26493620
23	Long nose (HP:0003189)	3.26419983
24	Agitation (HP:0000713)	3.20658661
25	Abnormality of the pons (HP:0007361)	3.11847612
26	Craniofacial dystonia (HP:0012179)	3.11444259
27	Hypolipoproteinemia (HP:0010981)	3.08800561
28	Abnormality of the 2nd finger (HP:0004100)	3.07274073
29	Focal dystonia (HP:0004373)	2.92112132
30	Congenital glaucoma (HP:0001087)	2.82671390
31	Amblyopia (HP:0000646)	2.81853294
32	Ketoacidosis (HP:0001993)	2.80491629
33	Hypoplasia of the pons (HP:0012110)	2.80221168
34	Poikilocytosis (HP:0004447)	2.78007910
35	Restlessness (HP:0000711)	2.77120855
36	Partial duplication of the phalanx of hand (HP:0009999)	2.72682989
37	Progressive muscle weakness (HP:0003323)	2.69307291
38	Abnormality of fatty-acid metabolism (HP:0004359)	2.63193859
39	CNS demyelination (HP:0007305)	2.60856838
40	Microretrognathia (HP:0000308)	2.58701404
41	Carpal bone hypoplasia (HP:0001498)	2.58273588
42	Stenosis of the external auditory canal (HP:0000402)	2.58180118
43	Delayed closure of the anterior fontanelle (HP:0001476)	2.56890655
44	Hemiplegia (HP:0002301)	2.54926896
45	Impaired smooth pursuit (HP:0007772)	2.51155160
46	Large eyes (HP:0001090)	2.48924996
47	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.45670693
48	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.43301130
49	Abnormality of alanine metabolism (HP:0010916)	2.43301130
50	Hyperalaninemia (HP:0003348)	2.43301130
51	Congenital sensorineural hearing impairment (HP:0008527)	2.36981559
52	Abnormality of vitamin metabolism (HP:0100508)	2.35018154
53	EMG: neuropathic changes (HP:0003445)	2.32700885
54	Hepatic necrosis (HP:0002605)	2.32571976
55	Renal tubular dysfunction (HP:0000124)	2.29610274
56	Abnormality of glycolipid metabolism (HP:0010969)	2.26641855
57	Abnormality of liposaccharide metabolism (HP:0010968)	2.26641855
58	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.26641855
59	Buphthalmos (HP:0000557)	2.23092300
60	Morphological abnormality of the pyramidal tract (HP:0002062)	2.22629355
61	Clumsiness (HP:0002312)	2.22523631
62	Abnormality of serum amino acid levels (HP:0003112)	2.22409266
63	Congenital stationary night blindness (HP:0007642)	2.17823474
64	Coronal craniosynostosis (HP:0004440)	2.16320253
65	Elevated erythrocyte sedimentation rate (HP:0003565)	2.12627776
66	Macrocytic anemia (HP:0001972)	2.12573352
67	Decreased circulating renin level (HP:0003351)	2.09560606
68	Agnosia (HP:0010524)	2.07758434
69	Bradykinesia (HP:0002067)	2.07434371
70	Neurofibrillary tangles (HP:0002185)	2.06842483
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.06371852
72	Dicarboxylic aciduria (HP:0003215)	2.06371852
73	Hypoproteinemia (HP:0003075)	2.06124424
74	Ketosis (HP:0001946)	2.03842924
75	Orchitis (HP:0100796)	2.03551904
76	Hepatocellular necrosis (HP:0001404)	2.03454093
77	Abnormality of the parietal bone (HP:0002696)	2.02961974
78	Aplasia/hypoplasia of the uterus (HP:0008684)	2.02728287
79	Parakeratosis (HP:0001036)	2.01809587
80	Choreoathetosis (HP:0001266)	2.01420549
81	Abnormality of cells of the erythroid lineage (HP:0012130)	2.00714680
82	Poor suck (HP:0002033)	2.00558712
83	Increased CSF lactate (HP:0002490)	1.99786711
84	Rapidly progressive (HP:0003678)	1.95441514
85	Impulsivity (HP:0100710)	1.94832265
86	Turricephaly (HP:0000262)	1.93508982
87	Bicuspid aortic valve (HP:0001647)	1.88959376
88	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86630717
89	Abnormality of glycine metabolism (HP:0010895)	1.86630717
90	Chorioretinal atrophy (HP:0000533)	1.85848840
91	Tubulointerstitial abnormality (HP:0001969)	1.84880791
92	Generalized aminoaciduria (HP:0002909)	1.82663399
93	Cholelithiasis (HP:0001081)	1.79220229
94	Dyschromatopsia (HP:0007641)	1.78629648
95	Abnormal gallbladder morphology (HP:0012437)	1.78162114
96	Hypoglycemic coma (HP:0001325)	1.77383779
97	Hyperbilirubinemia (HP:0002904)	1.76544235
98	Delayed cranial suture closure (HP:0000270)	1.76252425
99	Abnormality of ocular smooth pursuit (HP:0000617)	1.75879108
100	Gliosis (HP:0002171)	1.75654441

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	6.27333445
2	PDK2	6.19547222
3	MAP2K6	3.82167457
4	TIE1	3.20198099
5	PASK	2.97440187
6	MAP4K2	2.47625983
7	TXK	2.01459508
8	FRK	1.91762439
9	GRK1	1.91518592
10	VRK2	1.89692581
11	AKT2	1.87634864
12	MAP3K6	1.85650742
13	STK38	1.75829846
14	MST4	1.66917741
15	SRPK1	1.63941282
16	NUAK1	1.63457487
17	PBK	1.56858156
18	PRKD2	1.52434338
19	ADRBK2	1.52260035
20	LCK	1.37279761
21	ZAK	1.34593054
22	PRKG2	1.33830825
23	WNK3	1.29293019
24	PKN1	1.25809594
25	VRK1	1.18281517
26	TGFBR1	1.18090844
27	TLK1	1.13493670
28	WNK4	1.12304985
29	MAP2K3	1.01656474
30	INSRR	0.98710281
31	TEC	0.94324730
32	ROCK2	0.92329547
33	TESK2	0.91820624
34	SYK	0.87816049
35	NTRK3	0.87201883
36	IRAK2	0.86167286
37	PRKCH	0.85023627
38	ADRBK1	0.83814549
39	ABL2	0.79499854
40	TBK1	0.79388245
41	PDK1	0.76417111
42	BMPR1B	0.75315635
43	STK39	0.75094601
44	FES	0.71947571
45	PIK3CG	0.70651776
46	ERBB4	0.70400993
47	PDPK1	0.70334128
48	STK16	0.69415662
49	PRKCQ	0.66815935
50	PIM1	0.65576365
51	CSF1R	0.63238575
52	YES1	0.63173423
53	OBSCN	0.60247839
54	PRKCA	0.60187838
55	PLK3	0.58944444
56	MAP4K1	0.58506932
57	CAMK2A	0.56260120
58	NME1	0.55114112
59	ZAP70	0.54730288
60	PRKCD	0.54709765
61	STK3	0.54568754
62	NEK2	0.53012489
63	PLK4	0.52599102
64	MAP3K5	0.52234407
65	MYLK	0.51819671
66	STK38L	0.50759102
67	PRKCG	0.50464176
68	CAMK2D	0.50305613
69	MAP2K4	0.50122206
70	CSNK2A1	0.48227153
71	RPS6KB1	0.47512530
72	PRKCE	0.47406128
73	MAP2K2	0.46506125
74	OXSR1	0.45684711
75	GRK5	0.44976071
76	MAP2K1	0.44063412
77	LIMK1	0.43034870
78	EIF2AK3	0.42832851
79	BRAF	0.41877708
80	ITK	0.41707236
81	CCNB1	0.39438838
82	INSR	0.39366015
83	TAOK3	0.39241874
84	PRKACA	0.39007241
85	EGFR	0.38221863
86	IGF1R	0.37218244
87	KDR	0.36113981
88	MATK	0.35828846
89	TSSK6	0.35242051
90	CSNK1G3	0.35212547
91	ROCK1	0.34894130
92	MUSK	0.34865431
93	CSNK1G1	0.34498212
94	FYN	0.33636394
95	ACVR1B	0.33112213
96	PIK3CA	0.33002692
97	IRAK1	0.31930647
98	RPS6KB2	0.31888253
99	MAP3K12	0.31581932
100	KIT	0.31380761

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	5.18427249
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	4.30689429
3	Ribosome_Homo sapiens_hsa03010	4.25936797
4	Fructose and mannose metabolism_Homo sapiens_hsa00051	4.21568794
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.48734901
6	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	2.35176863
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29249221
8	Allograft rejection_Homo sapiens_hsa05330	2.29165172
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.18370666
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16417375
11	RNA degradation_Homo sapiens_hsa03018	2.15732530
12	Proteasome_Homo sapiens_hsa03050	2.02548951
13	Regulation of autophagy_Homo sapiens_hsa04140	1.99049982
14	Asthma_Homo sapiens_hsa05310	1.95839823
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.83660247
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.73502458
17	Propanoate metabolism_Homo sapiens_hsa00640	1.68280766
18	Fat digestion and absorption_Homo sapiens_hsa04975	1.60951094
19	Parkinsons disease_Homo sapiens_hsa05012	1.59227830
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.58046855
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.48194308
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.42227085
23	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.38226940
24	Phototransduction_Homo sapiens_hsa04744	1.37138415
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34452538
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.26400754
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.26352275
28	Caffeine metabolism_Homo sapiens_hsa00232	1.25097662
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.24366584
30	Tryptophan metabolism_Homo sapiens_hsa00380	1.20739488
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.20424022
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.18477089
33	Renin-angiotensin system_Homo sapiens_hsa04614	1.17395085
34	Peroxisome_Homo sapiens_hsa04146	1.07232047
35	RNA polymerase_Homo sapiens_hsa03020	1.03037674
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00268852
37	Nitrogen metabolism_Homo sapiens_hsa00910	0.99879505
38	Alzheimers disease_Homo sapiens_hsa05010	0.98347350
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.91466632
40	Collecting duct acid secretion_Homo sapiens_hsa04966	0.86732029
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82439649
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82353608
43	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.79446415
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78734351
45	Retinol metabolism_Homo sapiens_hsa00830	0.78058357
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73865136
47	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.73431422
48	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73019065
49	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72901135
50	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70882556
51	Insulin secretion_Homo sapiens_hsa04911	0.70349916
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68272116
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68182401
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.67900470
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67712156
56	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.67293681
57	Huntingtons disease_Homo sapiens_hsa05016	0.62323723
58	Glutathione metabolism_Homo sapiens_hsa00480	0.61635261
59	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.59463019
60	Pyruvate metabolism_Homo sapiens_hsa00620	0.58755181
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58346283
62	Metabolic pathways_Homo sapiens_hsa01100	0.56683793
63	Renin secretion_Homo sapiens_hsa04924	0.56129348
64	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.55921378
65	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55658483
66	Protein export_Homo sapiens_hsa03060	0.54145021
67	Butanoate metabolism_Homo sapiens_hsa00650	0.52954950
68	Purine metabolism_Homo sapiens_hsa00230	0.52536259
69	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52015442
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.51330890
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.48236736
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47739804
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45628435
74	Mismatch repair_Homo sapiens_hsa03430	0.44235536
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42527768
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41041659
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.39859105
78	Histidine metabolism_Homo sapiens_hsa00340	0.38376203
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37277588
80	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.33666421
81	Mineral absorption_Homo sapiens_hsa04978	0.33497931
82	Olfactory transduction_Homo sapiens_hsa04740	0.33234154
83	Pancreatic secretion_Homo sapiens_hsa04972	0.33055204
84	Taste transduction_Homo sapiens_hsa04742	0.32714494
85	Basal transcription factors_Homo sapiens_hsa03022	0.32414883
86	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.30800273
87	Protein digestion and absorption_Homo sapiens_hsa04974	0.29289476
88	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.26918611
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26669412
90	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22938082
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.22757205
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.22203591
93	Serotonergic synapse_Homo sapiens_hsa04726	0.21800685
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.21099607
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.20732911
96	Salivary secretion_Homo sapiens_hsa04970	0.20253688
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.19961491
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19880864
99	Homologous recombination_Homo sapiens_hsa03440	0.17810458
100	Fatty acid degradation_Homo sapiens_hsa00071	0.17331988

SLC25A6P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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