ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neuron remodeling (GO:0016322)	7.03395858
2	regulation of mitotic spindle organization (GO:0060236)	7.02390322
3	S-adenosylmethionine metabolic process (GO:0046500)	6.00759200
4	positive regulation of triglyceride biosynthetic process (GO:0010867)	5.48527959
5	lateral sprouting from an epithelium (GO:0060601)	5.27265091
6	DNA double-strand break processing (GO:0000729)	5.25576767
7	keratinocyte development (GO:0003334)	5.04340198
8	regulation of hippo signaling (GO:0035330)	4.94765991
9	tryptophan catabolic process (GO:0006569)	4.76729252
10	indole-containing compound catabolic process (GO:0042436)	4.76729252
11	indolalkylamine catabolic process (GO:0046218)	4.76729252
12	mRNA modification (GO:0016556)	4.72297642
13	positive regulation of receptor activity (GO:2000273)	4.63059639
14	substrate-dependent cell migration (GO:0006929)	4.57013893
15	regulation of transforming growth factor beta2 production (GO:0032909)	4.56664506
16	regulation of spindle organization (GO:0090224)	4.48612627
17	positive regulation of glycoprotein biosynthetic process (GO:0010560)	4.26107406
18	regulation of triglyceride biosynthetic process (GO:0010866)	4.11085014
19	regulation of meiosis I (GO:0060631)	4.10672723
20	tryptophan metabolic process (GO:0006568)	4.06562376
21	cornea development in camera-type eye (GO:0061303)	4.05886800
22	sulfation (GO:0051923)	4.01235506
23	glial cell proliferation (GO:0014009)	4.01198012
24	genitalia morphogenesis (GO:0035112)	3.99299817
25	retinal cone cell development (GO:0046549)	3.95269850
26	histone H3-K4 trimethylation (GO:0080182)	3.90599584
27	hindbrain development (GO:0030902)	3.86583574
28	protein K11-linked deubiquitination (GO:0035871)	3.82608492
29	heparin metabolic process (GO:0030202)	3.76742527
30	heparin biosynthetic process (GO:0030210)	3.76742527
31	DNA replication checkpoint (GO:0000076)	3.71524505
32	organ formation (GO:0048645)	3.69401857
33	oligosaccharide biosynthetic process (GO:0009312)	3.64643810
34	generation of neurons (GO:0048699)	3.63989709
35	negative regulation of translational initiation (GO:0045947)	3.61739126
36	positive regulation of T cell differentiation in thymus (GO:0033089)	3.60663698
37	RNA destabilization (GO:0050779)	3.56697415
38	head development (GO:0060322)	3.56624244
39	indolalkylamine metabolic process (GO:0006586)	3.56246200
40	adaptation of signaling pathway (GO:0023058)	3.46264252
41	aromatic amino acid family catabolic process (GO:0009074)	3.46148269
42	cellular response to virus (GO:0098586)	3.45137176
43	estrogen metabolic process (GO:0008210)	3.43023185
44	peptidyl-lysine trimethylation (GO:0018023)	3.42991423
45	regulation of mitotic spindle checkpoint (GO:1903504)	3.39303451
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.39303451
47	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.39098671
48	embryonic hemopoiesis (GO:0035162)	3.35898529
49	neuron maturation (GO:0042551)	3.33476358
50	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.33120722
51	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.33120722
52	transmission of nerve impulse (GO:0019226)	3.32401901
53	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	3.30377691
54	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.26689747
55	ephrin receptor signaling pathway (GO:0048013)	3.25732698
56	flavonoid metabolic process (GO:0009812)	3.23225118
57	positive regulation of developmental pigmentation (GO:0048087)	3.22861877
58	protein export from nucleus (GO:0006611)	3.21763889
59	positive regulation of triglyceride metabolic process (GO:0090208)	3.13139496
60	morphogenesis of an epithelial fold (GO:0060571)	3.12569410
61	histone lysine methylation (GO:0034968)	3.11067184
62	positive regulation of fibroblast migration (GO:0010763)	3.10853215
63	tRNA modification (GO:0006400)	3.09131150
64	centriole replication (GO:0007099)	3.08120641
65	detection of light stimulus involved in sensory perception (GO:0050962)	3.01414047
66	detection of light stimulus involved in visual perception (GO:0050908)	3.01414047
67	DNA packaging (GO:0006323)	2.98833409
68	positive regulation of glycoprotein metabolic process (GO:1903020)	2.98334490
69	negative regulation of neurotransmitter secretion (GO:0046929)	2.97805629
70	limb bud formation (GO:0060174)	2.95809471
71	cellular biogenic amine catabolic process (GO:0042402)	2.94011786
72	amine catabolic process (GO:0009310)	2.94011786
73	piRNA metabolic process (GO:0034587)	2.92136778
74	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.89361752
75	regulation of translation, ncRNA-mediated (GO:0045974)	2.89361752
76	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.89361752
77	positive regulation of RNA splicing (GO:0033120)	2.88909766
78	recombinational repair (GO:0000725)	2.88889283
79	double-strand break repair via homologous recombination (GO:0000724)	2.88261500
80	pancreas development (GO:0031016)	2.87689956
81	nuclear pore complex assembly (GO:0051292)	2.84114574
82	positive regulation of fatty acid transport (GO:2000193)	2.82729538
83	somatic stem cell maintenance (GO:0035019)	2.80263400
84	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.80137404
85	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.80137404
86	kynurenine metabolic process (GO:0070189)	2.79845596
87	intra-S DNA damage checkpoint (GO:0031573)	2.79807649
88	left/right axis specification (GO:0070986)	2.77847618
89	mannosylation (GO:0097502)	2.77323494
90	negative regulation of endothelial cell apoptotic process (GO:2000352)	2.77310220
91	polyol transport (GO:0015791)	2.74518485
92	positive regulation of receptor internalization (GO:0002092)	2.74224911
93	pore complex assembly (GO:0046931)	2.73873774
94	regulation of MHC class I biosynthetic process (GO:0045343)	2.73163766
95	regulation of viral entry into host cell (GO:0046596)	2.70233034
96	adenosine metabolic process (GO:0046085)	2.68104506
97	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.68054411
98	phosphatidylglycerol biosynthetic process (GO:0006655)	2.67639959
99	protein targeting to vacuole (GO:0006623)	2.67532579
100	establishment of protein localization to vacuole (GO:0072666)	2.67532579

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.15087587
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32178990
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.27255237
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.11798163
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.80234618
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.78247938
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.33748271
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30207571
9	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.23467739
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.23312331
11	VDR_22108803_ChIP-Seq_LS180_Human	2.22503584
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18427311
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02958817
14	AHR_22903824_ChIP-Seq_MCF-7_Human	2.01432793
15	SUZ12_27294783_Chip-Seq_NPCs_Mouse	2.00431572
16	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.99954944
17	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.98453561
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97631090
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87040409
20	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.84810200
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84727202
22	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.84135931
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.80774712
24	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.80774712
25	FUS_26573619_Chip-Seq_HEK293_Human	1.78153477
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75103488
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.73040588
28	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.72974855
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.72482480
30	P300_19829295_ChIP-Seq_ESCs_Human	1.67279757
31	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.59848075
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54903217
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.54313804
34	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.52937020
35	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.50672007
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47004858
37	TCF4_22108803_ChIP-Seq_LS180_Human	1.46448174
38	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.45896840
39	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44125226
40	EWS_26573619_Chip-Seq_HEK293_Human	1.43303456
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42526863
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.41797449
43	NCOR_22424771_ChIP-Seq_293T_Human	1.41048495
44	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37335314
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36545130
46	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.35875867
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35547607
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.34013210
49	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.33688598
50	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.33334739
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32783633
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29248111
53	PHF8_20622853_ChIP-Seq_HELA_Human	1.28241697
54	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26570183
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.26556859
56	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.26315730
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.25945650
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23921243
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23135260
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.22549822
61	TCF4_23295773_ChIP-Seq_U87_Human	1.21322671
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21172108
63	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.20725597
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20201371
65	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20195676
66	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.19927027
67	STAT3_23295773_ChIP-Seq_U87_Human	1.18891492
68	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16095055
69	GATA1_22025678_ChIP-Seq_K562_Human	1.15774117
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.14977946
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14694858
72	P300_18555785_Chip-Seq_ESCs_Mouse	1.14190061
73	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.14089176
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13462076
75	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.12494287
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.11678545
77	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.11572061
78	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.11324945
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.10572314
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.10484614
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10375714
82	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09687833
83	RBPJ_21746931_ChIP-Seq_IB4_Human	1.09444567
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.09424544
85	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09400142
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.09351055
87	AR_25329375_ChIP-Seq_VCAP_Human	1.08788080
88	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.08370306
89	TBL1_22424771_ChIP-Seq_293T_Human	1.08273863
90	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.07255100
91	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06542173
92	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06542173
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06495753
94	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06495753
95	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.06027421
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04819522
97	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.04423805
98	NFYB_21822215_ChIP-Seq_K562_Human	1.04397389
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04152144
100	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.03534588

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002160_abnormal_reproductive_system	4.58797491
2	MP0004147_increased_porphyrin_level	4.40741102
3	MP0001727_abnormal_embryo_implantation	4.35777607
4	MP0003172_abnormal_lysosome_physiology	3.54479113
5	MP0001919_abnormal_reproductive_system	3.04328734
6	MP0003693_abnormal_embryo_hatching	2.67400548
7	MP0005075_abnormal_melanosome_morpholog	2.65140274
8	MP0000015_abnormal_ear_pigmentation	2.47185942
9	MP0001188_hyperpigmentation	2.45398482
10	MP0005389_reproductive_system_phenotype	2.26360785
11	MP0001873_stomach_inflammation	2.22254828
12	MP0003950_abnormal_plasma_membrane	2.20671214
13	MP0000537_abnormal_urethra_morphology	2.20099221
14	MP0001346_abnormal_lacrimal_gland	2.13802772
15	MP0002138_abnormal_hepatobiliary_system	2.11722237
16	MP0002282_abnormal_trachea_morphology	2.07722994
17	MP0002102_abnormal_ear_morphology	2.06596629
18	MP0005551_abnormal_eye_electrophysiolog	2.04473804
19	MP0005646_abnormal_pituitary_gland	1.97799145
20	MP0001529_abnormal_vocalization	1.92734479
21	MP0009697_abnormal_copulation	1.90746009
22	MP0000383_abnormal_hair_follicle	1.90271761
23	MP0010094_abnormal_chromosome_stability	1.87382238
24	MP0006292_abnormal_olfactory_placode	1.84944659
25	MP0003718_maternal_effect	1.80469351
26	MP0000613_abnormal_salivary_gland	1.71476857
27	MP0003656_abnormal_erythrocyte_physiolo	1.70504098
28	MP0008058_abnormal_DNA_repair	1.68905479
29	MP0008872_abnormal_physiological_respon	1.68275808
30	MP0004808_abnormal_hematopoietic_stem	1.62007650
31	MP0003045_fibrosis	1.58624257
32	MP0000427_abnormal_hair_cycle	1.58597553
33	MP0005248_abnormal_Harderian_gland	1.55622546
34	MP0000569_abnormal_digit_pigmentation	1.54459117
35	MP0005410_abnormal_fertilization	1.48535709
36	MP0008877_abnormal_DNA_methylation	1.47694999
37	MP0005395_other_phenotype	1.47539769
38	MP0000647_abnormal_sebaceous_gland	1.45487827
39	MP0000467_abnormal_esophagus_morphology	1.45382037
40	MP0006072_abnormal_retinal_apoptosis	1.44617070
41	MP0002938_white_spotting	1.44424852
42	MP0003303_peritoneal_inflammation	1.42229920
43	MP0000631_abnormal_neuroendocrine_gland	1.41782115
44	MP0002168_other_aberrant_phenotype	1.41193039
45	MP0009333_abnormal_splenocyte_physiolog	1.32056691
46	MP0001764_abnormal_homeostasis	1.29208984
47	MP0005084_abnormal_gallbladder_morpholo	1.28786445
48	MP0003936_abnormal_reproductive_system	1.22176416
49	MP0001486_abnormal_startle_reflex	1.21859338
50	MP0000372_irregular_coat_pigmentation	1.21465160
51	MP0000627_abnormal_mammary_gland	1.18409458
52	MP0002254_reproductive_system_inflammat	1.17221486
53	MP0003698_abnormal_male_reproductive	1.16681610
54	MP0010678_abnormal_skin_adnexa	1.16586130
55	MP0004134_abnormal_chest_morphology	1.14475491
56	MP0003011_delayed_dark_adaptation	1.13922945
57	MP0003195_calcinosis	1.09073766
58	MP0001929_abnormal_gametogenesis	1.08528739
59	MP0000516_abnormal_urinary_system	1.08277160
60	MP0005367_renal/urinary_system_phenotyp	1.08277160
61	MP0000653_abnormal_sex_gland	1.02396124
62	MP0008007_abnormal_cellular_replicative	1.02339993
63	MP0004924_abnormal_behavior	1.00203276
64	MP0005386_behavior/neurological_phenoty	1.00203276
65	MP0001145_abnormal_male_reproductive	1.00141236
66	MP0000778_abnormal_nervous_system	0.99826066
67	MP0008995_early_reproductive_senescence	0.98535289
68	MP0002837_dystrophic_cardiac_calcinosis	0.97098047
69	MP0003786_premature_aging	0.88777573
70	MP0005253_abnormal_eye_physiology	0.88580194
71	MP0002098_abnormal_vibrissa_morphology	0.87867103
72	MP0001663_abnormal_digestive_system	0.83835656
73	MP0002638_abnormal_pupillary_reflex	0.81008998
74	MP0001485_abnormal_pinna_reflex	0.80003951
75	MP0000538_abnormal_urinary_bladder	0.79375992
76	MP0003252_abnormal_bile_duct	0.79102559
77	MP0000470_abnormal_stomach_morphology	0.78944575
78	MP0003787_abnormal_imprinting	0.78671871
79	MP0001851_eye_inflammation	0.76960463
80	MP0005187_abnormal_penis_morphology	0.75257596
81	MP0000049_abnormal_middle_ear	0.73906034
82	MP0005636_abnormal_mineral_homeostasis	0.73250531
83	MP0005085_abnormal_gallbladder_physiolo	0.72111583
84	MP0008789_abnormal_olfactory_epithelium	0.69436918
85	MP0003943_abnormal_hepatobiliary_system	0.69395312
86	MP0005464_abnormal_platelet_physiology	0.68020334
87	MP0005167_abnormal_blood-brain_barrier	0.67656220
88	MP0002557_abnormal_social/conspecific_i	0.67057030
89	MP0001177_atelectasis	0.66964971
90	MP0000371_diluted_coat_color	0.66607284
91	MP0002095_abnormal_skin_pigmentation	0.66549487
92	MP0002115_abnormal_skeleton_extremities	0.65454557
93	MP0005220_abnormal_exocrine_pancreas	0.64306203
94	MP0003121_genomic_imprinting	0.63286274
95	MP0010386_abnormal_urinary_bladder	0.62841703
96	MP0004133_heterotaxia	0.62512487
97	MP0005670_abnormal_white_adipose	0.62061856
98	MP0005365_abnormal_bile_salt	0.61849217
99	MP0002108_abnormal_muscle_morphology	0.60566230
100	MP0003763_abnormal_thymus_physiology	0.57719992

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperinsulinemic hypoglycemia (HP:0000825)	6.63200339
2	Albinism (HP:0001022)	4.13597651
3	Gonadotropin excess (HP:0000837)	3.85725723
4	Partial agenesis of the corpus callosum (HP:0001338)	3.78833964
5	Submucous cleft hard palate (HP:0000176)	3.59275568
6	Ectopic kidney (HP:0000086)	3.55818692
7	Hematochezia (HP:0002573)	3.52693035
8	Microretrognathia (HP:0000308)	3.37871402
9	Petechiae (HP:0000967)	3.24146661
10	Abnormality of midbrain morphology (HP:0002418)	3.23454012
11	Molar tooth sign on MRI (HP:0002419)	3.23454012
12	Thickened helices (HP:0000391)	3.14198100
13	Alveolar cell carcinoma (HP:0006519)	3.00002684
14	Action tremor (HP:0002345)	2.99270437
15	Exertional dyspnea (HP:0002875)	2.99052895
16	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.97261524
17	Aplastic anemia (HP:0001915)	2.91576721
18	Duplicated collecting system (HP:0000081)	2.82521768
19	Neoplasm of the tracheobronchial system (HP:0100552)	2.70004362
20	High anterior hairline (HP:0009890)	2.68730882
21	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.66849526
22	Short 1st metacarpal (HP:0010034)	2.66849526
23	Menstrual irregularities (HP:0000858)	2.65674313
24	Thyroid-stimulating hormone excess (HP:0002925)	2.61769837
25	Abnormality of the renal collecting system (HP:0004742)	2.57112583
26	Abnormality of the 1st metacarpal (HP:0010009)	2.46716170
27	Papilledema (HP:0001085)	2.45965668
28	Cystic hygroma (HP:0000476)	2.45233037
29	Pendular nystagmus (HP:0012043)	2.44981536
30	Wide nose (HP:0000445)	2.43297645
31	Nephronophthisis (HP:0000090)	2.40109160
32	Delayed CNS myelination (HP:0002188)	2.39152380
33	Abnormality of chromosome stability (HP:0003220)	2.38280765
34	Stomatitis (HP:0010280)	2.35810020
35	Selective tooth agenesis (HP:0001592)	2.34316621
36	Absent eyebrow (HP:0002223)	2.34189361
37	Curly hair (HP:0002212)	2.26482192
38	Depressed nasal tip (HP:0000437)	2.24837334
39	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.24339785
40	Posterior subcapsular cataract (HP:0007787)	2.23794587
41	Attenuation of retinal blood vessels (HP:0007843)	2.23760048
42	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.22016000
43	Asplenia (HP:0001746)	2.21000436
44	Myelodysplasia (HP:0002863)	2.20858543
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.19922923
46	Abnormal protein N-linked glycosylation (HP:0012347)	2.19922923
47	Abnormal protein glycosylation (HP:0012346)	2.19922923
48	Abnormal glycosylation (HP:0012345)	2.19922923
49	Abnormal rod and cone electroretinograms (HP:0008323)	2.19626699
50	Abnormality of the renal medulla (HP:0100957)	2.18015366
51	Abnormality of the labia minora (HP:0012880)	2.13710740
52	Type I transferrin isoform profile (HP:0003642)	2.13201282
53	Narrow forehead (HP:0000341)	2.12817791
54	Tachypnea (HP:0002789)	2.12373635
55	Abnormality of the antihelix (HP:0009738)	2.09985609
56	Lissencephaly (HP:0001339)	2.09555637
57	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.08770318
58	Increased CSF protein (HP:0002922)	2.06520847
59	Congenital stationary night blindness (HP:0007642)	2.02956634
60	Abnormal number of incisors (HP:0011064)	2.01989873
61	Pancreatic cysts (HP:0001737)	2.01179324
62	Anophthalmia (HP:0000528)	2.01149811
63	Severe visual impairment (HP:0001141)	1.96785134
64	Bulbous nose (HP:0000414)	1.96442676
65	Concave nail (HP:0001598)	1.95565269
66	Chronic hepatic failure (HP:0100626)	1.93586529
67	Colon cancer (HP:0003003)	1.90870885
68	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.89233092
69	Opisthotonus (HP:0002179)	1.88887803
70	Dysdiadochokinesis (HP:0002075)	1.87730322
71	Fair hair (HP:0002286)	1.86465220
72	Chorioretinal atrophy (HP:0000533)	1.85798277
73	Impaired platelet aggregation (HP:0003540)	1.85308775
74	Abnormal platelet function (HP:0011869)	1.85308775
75	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.84675989
76	Epidermoid cyst (HP:0200040)	1.83779950
77	Short phalanx of the thumb (HP:0009660)	1.83184911
78	Abnormality of the pons (HP:0007361)	1.82875299
79	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.82772035
80	Absent eyelashes (HP:0000561)	1.80035656
81	Bile duct proliferation (HP:0001408)	1.79991497
82	Abnormal biliary tract physiology (HP:0012439)	1.79991497
83	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.78757491
84	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.77684419
85	Long clavicles (HP:0000890)	1.77014010
86	Abnormality of macular pigmentation (HP:0008002)	1.76442196
87	Absent hair (HP:0002298)	1.74841486
88	Heterotopia (HP:0002282)	1.74668354
89	Focal motor seizures (HP:0011153)	1.73210593
90	Intention tremor (HP:0002080)	1.72584646
91	Macular degeneration (HP:0000608)	1.72401442
92	Clumsiness (HP:0002312)	1.70398875
93	Abnormality of chromosome segregation (HP:0002916)	1.69245487
94	Poor eye contact (HP:0000817)	1.69153213
95	True hermaphroditism (HP:0010459)	1.68998501
96	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.68071636
97	Lip pit (HP:0100267)	1.67517880
98	Optic nerve hypoplasia (HP:0000609)	1.66904539
99	Pancreatic islet-cell hyperplasia (HP:0004510)	1.66674484
100	Facial hemangioma (HP:0000329)	1.65518800

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	AKT3	6.33114449
2	TNIK	5.70518440
3	PNCK	5.22478175
4	MAP4K2	4.76429093
5	CDK9	3.81679220
6	NLK	3.63126757
7	GRK1	3.19297157
8	EIF2AK3	2.58602019
9	WEE1	2.51738894
10	TTK	2.18740900
11	BRAF	2.17742185
12	MUSK	1.91931432
13	PLK4	1.83554648
14	EPHB2	1.82575396
15	NUAK1	1.77944867
16	EPHA3	1.66296956
17	PIM2	1.59490546
18	EIF2AK1	1.52875549
19	FRK	1.44241047
20	VRK1	1.43948159
21	WNK3	1.41804459
22	INSRR	1.31416213
23	CDC7	1.28750826
24	BRSK2	1.28123088
25	FER	1.26848587
26	SGK2	1.12696167
27	TAF1	1.01169828
28	PRKCE	1.00092233
29	MAP2K2	0.95815441
30	DYRK2	0.92796829
31	PAK3	0.92434747
32	MAPKAPK5	0.88462977
33	MAPKAPK3	0.84253831
34	MELK	0.81722249
35	PIK3CA	0.78061150
36	VRK2	0.69348928
37	MST4	0.68603025
38	OXSR1	0.65895261
39	CDK8	0.64887218
40	ADRBK2	0.63510626
41	PLK3	0.63206554
42	TRIM28	0.59345130
43	CAMK1G	0.58720496
44	CSNK1G2	0.56158983
45	SGK494	0.53822088
46	SGK223	0.53822088
47	IKBKB	0.53209303
48	BCR	0.53061402
49	ZAK	0.52861477
50	PRKCG	0.52036306
51	SGK3	0.50982714
52	EPHA4	0.50085210
53	PINK1	0.49079278
54	PRKCI	0.47840649
55	MAP2K1	0.47386005
56	ATR	0.46339701
57	RPS6KB1	0.45207475
58	ZAP70	0.44923113
59	CHUK	0.44838769
60	MAPK3	0.44287809
61	PIK3CG	0.43893223
62	CSNK1G3	0.42938551
63	ABL1	0.42490769
64	CSNK1A1L	0.41704755
65	MAP3K4	0.41440958
66	TNK2	0.40357499
67	RPS6KA4	0.39047813
68	PLK1	0.38525813
69	TLK1	0.38411974
70	ABL2	0.37953524
71	ERBB2	0.36939583
72	ATM	0.33210400
73	DYRK3	0.32117999
74	CSNK2A1	0.31728320
75	MAPK1	0.31396642
76	MAPK13	0.30757505
77	CSNK1G1	0.29258875
78	GSK3A	0.28775731
79	HIPK2	0.28660831
80	RPS6KA5	0.28126373
81	PLK2	0.27815134
82	MKNK2	0.27135473
83	IRAK1	0.22574492
84	MAP2K6	0.22332828
85	STK39	0.22108951
86	CHEK2	0.21075606
87	CDK3	0.19375470
88	CSNK1D	0.19086621
89	LATS1	0.17633799
90	STK38L	0.17376770
91	RPS6KA6	0.17133159
92	CSNK2A2	0.17112737
93	DYRK1A	0.15959246
94	MAPK11	0.15561583
95	CSNK1E	0.15505884
96	PRKCZ	0.14878606
97	PRKD1	0.13164790
98	CAMK1	0.12022134
99	RPS6KL1	0.11999964
100	RPS6KC1	0.11999964

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Selenocompound metabolism_Homo sapiens_hsa00450	3.85519589
2	Sulfur metabolism_Homo sapiens_hsa00920	3.31442959
3	Thyroid cancer_Homo sapiens_hsa05216	2.98447231
4	Lysine degradation_Homo sapiens_hsa00310	2.96521721
5	Homologous recombination_Homo sapiens_hsa03440	2.91039987
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.41705581
7	Basal transcription factors_Homo sapiens_hsa03022	2.35125940
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.18795922
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.10284267
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.08843124
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.00190366
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.96590229
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.93967243
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90333759
15	Basal cell carcinoma_Homo sapiens_hsa05217	1.89404085
16	beta-Alanine metabolism_Homo sapiens_hsa00410	1.87001028
17	RNA degradation_Homo sapiens_hsa03018	1.85456076
18	DNA replication_Homo sapiens_hsa03030	1.85172456
19	Prostate cancer_Homo sapiens_hsa05215	1.74265977
20	Butanoate metabolism_Homo sapiens_hsa00650	1.69455453
21	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.67430359
22	Phototransduction_Homo sapiens_hsa04744	1.53574050
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.48299438
24	Endometrial cancer_Homo sapiens_hsa05213	1.39523577
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.39358133
26	Acute myeloid leukemia_Homo sapiens_hsa05221	1.37142943
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36700850
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.36192593
29	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.35608409
30	Tight junction_Homo sapiens_hsa04530	1.28944958
31	Histidine metabolism_Homo sapiens_hsa00340	1.24706665
32	Fatty acid elongation_Homo sapiens_hsa00062	1.23458412
33	ABC transporters_Homo sapiens_hsa02010	1.20545919
34	Colorectal cancer_Homo sapiens_hsa05210	1.16748405
35	RNA transport_Homo sapiens_hsa03013	1.15902758
36	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.10258912
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.08182068
38	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.04215032
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.00148182
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.96702455
41	Protein export_Homo sapiens_hsa03060	0.94736725
42	Cocaine addiction_Homo sapiens_hsa05030	0.94241895
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.92534102
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.92409514
45	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92127271
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85453167
47	p53 signaling pathway_Homo sapiens_hsa04115	0.82858652
48	Mismatch repair_Homo sapiens_hsa03430	0.80918588
49	Purine metabolism_Homo sapiens_hsa00230	0.80806374
50	Peroxisome_Homo sapiens_hsa04146	0.78366982
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77835517
52	Hippo signaling pathway_Homo sapiens_hsa04390	0.76197153
53	Salivary secretion_Homo sapiens_hsa04970	0.75782422
54	Tyrosine metabolism_Homo sapiens_hsa00350	0.75411107
55	RNA polymerase_Homo sapiens_hsa03020	0.74047896
56	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73929665
57	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.73467764
58	Cell cycle_Homo sapiens_hsa04110	0.72477885
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70619884
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65702898
61	Retinol metabolism_Homo sapiens_hsa00830	0.65041222
62	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62340856
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61580760
64	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.60963286
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59779475
66	mTOR signaling pathway_Homo sapiens_hsa04150	0.58740213
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.58301561
68	Non-homologous end-joining_Homo sapiens_hsa03450	0.57933401
69	One carbon pool by folate_Homo sapiens_hsa00670	0.55695885
70	Non-small cell lung cancer_Homo sapiens_hsa05223	0.55484671
71	Sulfur relay system_Homo sapiens_hsa04122	0.55362470
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50340142
73	Melanoma_Homo sapiens_hsa05218	0.49737318
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49449019
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48879000
76	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.46451739
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46276990
78	Pancreatic cancer_Homo sapiens_hsa05212	0.45840560
79	Insulin secretion_Homo sapiens_hsa04911	0.45646194
80	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45243289
81	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.44606438
82	Regulation of autophagy_Homo sapiens_hsa04140	0.44468685
83	Caffeine metabolism_Homo sapiens_hsa00232	0.40989767
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.40981891
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40299698
86	Bladder cancer_Homo sapiens_hsa05219	0.38402976
87	Propanoate metabolism_Homo sapiens_hsa00640	0.37063583
88	Base excision repair_Homo sapiens_hsa03410	0.34945770
89	Pancreatic secretion_Homo sapiens_hsa04972	0.34827580
90	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34498496
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31887364
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.31253529
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.31028930
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.30241235
95	Wnt signaling pathway_Homo sapiens_hsa04310	0.30012795
96	Circadian rhythm_Homo sapiens_hsa04710	0.29648348
97	Alcoholism_Homo sapiens_hsa05034	0.29281326
98	Hepatitis C_Homo sapiens_hsa05160	0.27504748
99	Nicotine addiction_Homo sapiens_hsa05033	0.25843738
100	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25823927

SLC25A6P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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