SLC26A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62115140
2L-phenylalanine catabolic process (GO:0006559)7.62115140
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.30367484
4L-phenylalanine metabolic process (GO:0006558)7.30367484
5aromatic amino acid family catabolic process (GO:0009074)6.91508696
6indole-containing compound catabolic process (GO:0042436)6.29863365
7indolalkylamine catabolic process (GO:0046218)6.29863365
8tryptophan catabolic process (GO:0006569)6.29863365
9glyoxylate metabolic process (GO:0046487)6.08311932
10kynurenine metabolic process (GO:0070189)6.03741716
11tryptophan metabolic process (GO:0006568)5.92519003
12bile acid biosynthetic process (GO:0006699)5.92102068
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.90395638
14cysteine metabolic process (GO:0006534)5.64891513
15urea metabolic process (GO:0019627)5.54632392
16urea cycle (GO:0000050)5.54632392
17alpha-linolenic acid metabolic process (GO:0036109)5.46564683
18sulfur amino acid catabolic process (GO:0000098)5.35600258
19negative regulation of fibrinolysis (GO:0051918)5.34257993
20serine family amino acid catabolic process (GO:0009071)5.28069409
21high-density lipoprotein particle remodeling (GO:0034375)5.22714193
22peptidyl-glutamic acid carboxylation (GO:0017187)5.18194393
23protein carboxylation (GO:0018214)5.18194393
24complement activation, alternative pathway (GO:0006957)5.17272739
25regulation of plasminogen activation (GO:0010755)5.16437263
26regulation of protein activation cascade (GO:2000257)5.14799993
27regulation of fibrinolysis (GO:0051917)5.14586736
28nitrogen cycle metabolic process (GO:0071941)5.11186462
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.05460541
30lysine metabolic process (GO:0006553)5.03892401
31lysine catabolic process (GO:0006554)5.03892401
32bile acid metabolic process (GO:0008206)5.03142743
33aromatic amino acid family metabolic process (GO:0009072)5.02716868
34homocysteine metabolic process (GO:0050667)4.94793917
35regulation of complement activation (GO:0030449)4.81570035
36tyrosine metabolic process (GO:0006570)4.75679617
37alpha-amino acid catabolic process (GO:1901606)4.72017535
38amino-acid betaine metabolic process (GO:0006577)4.71812895
39regulation of cholesterol biosynthetic process (GO:0045540)4.57072647
40reverse cholesterol transport (GO:0043691)4.56246702
41cellular ketone body metabolic process (GO:0046950)4.54923990
42regulation of triglyceride catabolic process (GO:0010896)4.54883796
43regulation of cholesterol esterification (GO:0010872)4.51984913
44proline metabolic process (GO:0006560)4.51979884
45protein-lipid complex remodeling (GO:0034368)4.47614224
46macromolecular complex remodeling (GO:0034367)4.47614224
47plasma lipoprotein particle remodeling (GO:0034369)4.47614224
48indolalkylamine metabolic process (GO:0006586)4.46393831
49triglyceride homeostasis (GO:0070328)4.44597137
50acylglycerol homeostasis (GO:0055090)4.44597137
51glycine metabolic process (GO:0006544)4.41198996
52cellular glucuronidation (GO:0052695)4.40828115
53coenzyme catabolic process (GO:0009109)4.38019735
54serine family amino acid metabolic process (GO:0009069)4.37778013
55cellular amino acid catabolic process (GO:0009063)4.36997648
56intestinal cholesterol absorption (GO:0030299)4.36468395
57negative regulation of cholesterol transport (GO:0032375)4.36413039
58negative regulation of sterol transport (GO:0032372)4.36413039
59amine catabolic process (GO:0009310)4.35689867
60cellular biogenic amine catabolic process (GO:0042402)4.35689867
61glutamate metabolic process (GO:0006536)4.34817850
62bile acid and bile salt transport (GO:0015721)4.32409066
63protein-lipid complex assembly (GO:0065005)4.30446623
64epoxygenase P450 pathway (GO:0019373)4.29627515
65phospholipid efflux (GO:0033700)4.24897472
66cellular modified amino acid catabolic process (GO:0042219)4.24873600
67drug catabolic process (GO:0042737)4.22739380
68benzene-containing compound metabolic process (GO:0042537)4.22620564
69imidazole-containing compound metabolic process (GO:0052803)4.22434298
70plasma lipoprotein particle clearance (GO:0034381)4.14468291
71serine family amino acid biosynthetic process (GO:0009070)4.13666203
72ethanol oxidation (GO:0006069)4.12734154
73plasma lipoprotein particle organization (GO:0071827)4.12373505
74dicarboxylic acid biosynthetic process (GO:0043650)4.07491857
75urate metabolic process (GO:0046415)4.07395497
76drug transmembrane transport (GO:0006855)4.06428813
77aldehyde catabolic process (GO:0046185)4.03100343
78positive regulation of fatty acid biosynthetic process (GO:0045723)4.02000245
79regulation of apoptotic cell clearance (GO:2000425)3.97985131
80uronic acid metabolic process (GO:0006063)3.97205449
81glucuronate metabolic process (GO:0019585)3.97205449
82cholesterol efflux (GO:0033344)3.96074781
83protein-lipid complex subunit organization (GO:0071825)3.94787433
84ketone body metabolic process (GO:1902224)3.94055789
85arginine metabolic process (GO:0006525)3.92882874
86short-chain fatty acid metabolic process (GO:0046459)3.90586474
87fibrinolysis (GO:0042730)3.85426064
88regulation of cholesterol metabolic process (GO:0090181)3.83088276
89acetyl-CoA metabolic process (GO:0006084)3.82771031
90carboxylic acid catabolic process (GO:0046395)3.82449394
91organic acid catabolic process (GO:0016054)3.82449394
92omega-hydroxylase P450 pathway (GO:0097267)3.81349424
93positive regulation of lipid catabolic process (GO:0050996)3.79943599
94plasma lipoprotein particle assembly (GO:0034377)3.78497402
95exogenous drug catabolic process (GO:0042738)3.78392026
96regulation of bile acid biosynthetic process (GO:0070857)3.76025118
97cofactor catabolic process (GO:0051187)3.75241104
98low-density lipoprotein particle remodeling (GO:0034374)3.74642290
99regulation of cholesterol homeostasis (GO:2000188)3.73550067
100acute-phase response (GO:0006953)3.72168255
101phospholipid homeostasis (GO:0055091)3.71823461
102aspartate family amino acid catabolic process (GO:0009068)3.69596089
103blood coagulation, intrinsic pathway (GO:0007597)3.66564407
104cholesterol homeostasis (GO:0042632)3.64838706
105complement activation, classical pathway (GO:0006958)3.61923159
106sterol homeostasis (GO:0055092)3.60207453
107flavonoid metabolic process (GO:0009812)3.59785706
108positive regulation of triglyceride lipase activity (GO:0061365)3.58848658
109positive regulation of lipoprotein lipase activity (GO:0051006)3.58848658
110very-low-density lipoprotein particle assembly (GO:0034379)3.58189017
111complement activation (GO:0006956)3.57654355
112response to nitrosative stress (GO:0051409)3.56914022
113cytolysis (GO:0019835)3.56234483
1142-oxoglutarate metabolic process (GO:0006103)3.55622137
115proline biosynthetic process (GO:0006561)3.53528120
116mannose metabolic process (GO:0006013)3.51593188
117negative regulation of lipid transport (GO:0032369)3.51445044
118negative regulation of hemostasis (GO:1900047)3.41805132
119negative regulation of blood coagulation (GO:0030195)3.41805132
120positive regulation of hemostasis (GO:1900048)3.32181070
121positive regulation of blood coagulation (GO:0030194)3.32181070
122negative regulation of fatty acid transport (GO:2000192)3.29764219
123regulation of fatty acid biosynthetic process (GO:0042304)3.26403374
124negative regulation of lipase activity (GO:0060192)3.24460495
125lipoprotein metabolic process (GO:0042157)3.19732458
126positive regulation of steroid metabolic process (GO:0045940)3.13264411
127negative regulation of fatty acid biosynthetic process (GO:0045717)3.08812068
128protein activation cascade (GO:0072376)3.08454132
129positive regulation of extracellular matrix organization (GO:1903055)3.08310173
130positive regulation of coagulation (GO:0050820)3.03519787
131negative regulation of coagulation (GO:0050819)3.02869642
132glutamine family amino acid biosynthetic process (GO:0009084)3.01754262
133regulation of lipoprotein particle clearance (GO:0010984)2.96649152
134negative regulation of wound healing (GO:0061045)2.94276950
135opsonization (GO:0008228)2.94007428
136regulation of glucose import in response to insulin stimulus (GO:2001273)2.92057295
137regulation of humoral immune response (GO:0002920)2.90647085
138regulation of fatty acid beta-oxidation (GO:0031998)2.90457280
139positive regulation of triglyceride metabolic process (GO:0090208)2.89288416
140negative regulation of cell size (GO:0045792)2.87470511
141regulation of extracellular matrix organization (GO:1903053)2.86054417
142regulation of extracellular matrix disassembly (GO:0010715)2.84727722
143insulin-like growth factor receptor signaling pathway (GO:0048009)2.82879854
144cholesterol transport (GO:0030301)2.82707068
145sterol transport (GO:0015918)2.82707068
146drug metabolic process (GO:0017144)2.79610167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.39115218
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.18734155
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.84534987
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48860452
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.22354084
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.96620443
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.80300282
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04860081
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95956221
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.12750926
11VDR_21846776_ChIP-Seq_THP-1_Human2.65148115
12MYC_22102868_ChIP-Seq_BL_Human2.47579796
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.32484172
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.30358919
15RACK7_27058665_Chip-Seq_MCF-7_Human2.26567517
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22036251
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20327554
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16003178
19TCF7_22412390_ChIP-Seq_EML_Mouse2.12027611
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.11339736
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09951015
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03583474
23* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01709620
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8722624
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84994175
26KDM2B_26808549_Chip-Seq_DND41_Human1.81510241
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.64524164
28P68_20966046_ChIP-Seq_HELA_Human1.62506949
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60201531
30* KDM2B_26808549_Chip-Seq_K562_Human1.58383352
31CLOCK_20551151_ChIP-Seq_293T_Human1.56582445
32SMC4_20622854_ChIP-Seq_HELA_Human1.51024183
33GATA1_22025678_ChIP-Seq_K562_Human1.48225412
34* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48157557
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.45953193
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.44139903
37HTT_18923047_ChIP-ChIP_STHdh_Human1.43732778
38CREB1_26743006_Chip-Seq_LNCaP_Human1.43113756
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42419885
40VDR_24763502_ChIP-Seq_THP-1_Human1.40312842
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.39275295
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39146750
43DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37728033
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37074400
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33736471
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.32753359
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32618315
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31884497
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.31762909
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31588656
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29035869
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.27315401
53MAF_26560356_Chip-Seq_TH1_Human1.23981289
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23360254
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21263467
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20791035
57BCOR_27268052_Chip-Seq_Bcells_Human1.19791243
58RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18307287
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18084209
60MAF_26560356_Chip-Seq_TH2_Human1.17934030
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15362526
62ATF3_27146783_Chip-Seq_COLON_Human1.15116414
63* NCOR1_26117541_ChIP-Seq_K562_Human1.14901086
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13691041
65TP53_22127205_ChIP-Seq_IMR90_Human1.13478482
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.12214866
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11890877
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10517149
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10415683
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09415542
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09307182
72P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08666689
73RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08431642
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.07783992
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07157644
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05888978
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04389823
78UTX_26944678_Chip-Seq_JUKART_Human1.03399620
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02879407
80CTCF_27219007_Chip-Seq_Bcells_Human1.02720796
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02697153
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02690621
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02528116
84BCL6_27268052_Chip-Seq_Bcells_Human1.01351593
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.00743138
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00118315
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99806746
88MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98698195
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95046984
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91351941
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90994829
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.89672114
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88505749
94GATA4_25053715_ChIP-Seq_YYC3_Human0.87536006
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85883750
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82158466
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80472409
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80378600
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.75809912
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75728524
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75229978
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73977010
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72885276
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.72346240
105ZNF263_19887448_ChIP-Seq_K562_Human0.71761311
106* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71646092
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71492166
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68275458
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67007834
110ESR1_21235772_ChIP-Seq_MCF-7_Human0.66295910
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64247473
112NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64247473
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.63798638
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63095803
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62712203
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62465773
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.60853265
118LXR_22292898_ChIP-Seq_THP-1_Human0.59060629
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58358007
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57323470
121* CEBPB_22108803_ChIP-Seq_LS180_Human0.56738379
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55696465
123EGR1_19032775_ChIP-ChIP_M12_Human0.55243079
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.55112779
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.54005904
126MYC_19915707_ChIP-ChIP_AK7_Human0.53618182
127AR_20517297_ChIP-Seq_VCAP_Human0.53419780
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.52241068
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51083144
130GATA1_19941826_ChIP-Seq_K562_Human0.50648242
131CBP_21632823_ChIP-Seq_H3396_Human0.50051656
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49863869
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.49119842
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.48419522
135STAT1_17558387_ChIP-Seq_HELA_Human0.48379207
136GATA6_25053715_ChIP-Seq_YYC3_Human0.47262217
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45898807
138GATA2_19941826_ChIP-Seq_K562_Human0.45863425
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45633714
140PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45081018
141TAF2_19829295_ChIP-Seq_ESCs_Human0.43989955
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43113912
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42911818
144* P53_21459846_ChIP-Seq_SAOS-2_Human0.42200717
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40517685
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39929051
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.39205072
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.37998456
149CDX2_22108803_ChIP-Seq_LS180_Human0.37281306
150TAF15_26573619_Chip-Seq_HEK293_Human0.37119264
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.37107287
152BCAT_22108803_ChIP-Seq_LS180_Human0.37000128
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36589453
154SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36310684
155ERG_20517297_ChIP-Seq_VCAP_Human0.35618801
156CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35287209
157GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.34913965
158NCOR_22424771_ChIP-Seq_293T_Human0.34904301
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.34608084
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.34565064
161GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.34451433
162P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34193250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41944520
2* MP0005360_urolithiasis7.12010620
3MP0005085_abnormal_gallbladder_physiolo6.37450078
4MP0005365_abnormal_bile_salt6.12994363
5MP0008875_abnormal_xenobiotic_pharmacok5.17019317
6MP0003806_abnormal_nucleotide_metabolis4.19403481
7MP0003252_abnormal_bile_duct4.00222872
8MP0010329_abnormal_lipoprotein_level3.47146063
9MP0003172_abnormal_lysosome_physiology3.10880072
10MP0009840_abnormal_foam_cell3.10654466
11MP0003195_calcinosis3.04279200
12MP0005332_abnormal_amino_acid3.03385537
13MP0005083_abnormal_biliary_tract3.02705092
14MP0001666_abnormal_nutrient_absorption2.56234404
15MP0005076_abnormal_cell_differentiation2.55755686
16MP0004019_abnormal_vitamin_homeostasis2.48102828
17MP0003191_abnormal_cellular_cholesterol2.29575590
18MP0002138_abnormal_hepatobiliary_system2.29351283
19* MP0000609_abnormal_liver_physiology2.11598513
20MP0002118_abnormal_lipid_homeostasis2.08716480
21MP0003868_abnormal_feces_composition1.85982404
22* MP0005319_abnormal_enzyme/_coenzyme1.80920002
23MP0001764_abnormal_homeostasis1.67913276
24MP0000566_synostosis1.66710454
25MP0001849_ear_inflammation1.66367299
26MP0005584_abnormal_enzyme/coenzyme_acti1.63756481
27MP0002249_abnormal_larynx_morphology1.62758296
28MP0008260_abnormal_autophagy1.62321655
29MP0004185_abnormal_adipocyte_glucose1.61646440
30MP0002089_abnormal_postnatal_growth/wei1.54004489
31MP0003566_abnormal_cell_adhesion1.52943769
32* MP0009643_abnormal_urine_homeostasis1.47695142
33MP0005409_darkened_coat_color1.45945327
34MP0009697_abnormal_copulation1.43275769
35MP0005451_abnormal_body_composition1.40625165
36MP0003186_abnormal_redox_activity1.37863866
37MP0004858_abnormal_nervous_system1.36796115
38MP0003656_abnormal_erythrocyte_physiolo1.36443906
39MP0003011_delayed_dark_adaptation1.26926201
40MP0001915_intracranial_hemorrhage1.24724878
41MP0000858_altered_metastatic_potential1.19628746
42* MP0000598_abnormal_liver_morphology1.16202123
43MP0002166_altered_tumor_susceptibility1.11978418
44* MP0005636_abnormal_mineral_homeostasis1.11220270
45MP0005647_abnormal_sex_gland1.10901608
46MP0004947_skin_inflammation1.09302975
47MP0003453_abnormal_keratinocyte_physiol1.08410583
48MP0003705_abnormal_hypodermis_morpholog1.07744243
49MP0009764_decreased_sensitivity_to1.06025795
50MP0000678_abnormal_parathyroid_gland1.03976835
51MP0010234_abnormal_vibrissa_follicle1.03857782
52MP0000604_amyloidosis1.02675124
53MP0005375_adipose_tissue_phenotype1.02001307
54MP0003091_abnormal_cell_migration1.00135877
55MP0009763_increased_sensitivity_to0.98788680
56MP0008438_abnormal_cutaneous_collagen0.96614990
57MP0003879_abnormal_hair_cell0.95562981
58MP0004233_abnormal_muscle_weight0.95387154
59MP0000003_abnormal_adipose_tissue0.94322378
60MP0002254_reproductive_system_inflammat0.91525409
61MP0006036_abnormal_mitochondrial_physio0.90067816
62MP0001348_abnormal_lacrimal_gland0.89651223
63MP0005084_abnormal_gallbladder_morpholo0.89626490
64MP0005670_abnormal_white_adipose0.89440056
65* MP0009642_abnormal_blood_homeostasis0.88966091
66* MP0008469_abnormal_protein_level0.87600824
67MP0005408_hypopigmentation0.87483413
68MP0001873_stomach_inflammation0.85062605
69MP0005023_abnormal_wound_healing0.84106371
70MP0010368_abnormal_lymphatic_system0.83006328
71MP0000767_abnormal_smooth_muscle0.82596200
72MP0002876_abnormal_thyroid_physiology0.82081357
73MP0001756_abnormal_urination0.81041770
74MP0005220_abnormal_exocrine_pancreas0.80806712
75MP0002078_abnormal_glucose_homeostasis0.79850837
76MP0009765_abnormal_xenobiotic_induced0.77997877
77MP0005376_homeostasis/metabolism_phenot0.77658385
78MP0003115_abnormal_respiratory_system0.75531474
79MP0004883_abnormal_blood_vessel0.75413452
80MP0001661_extended_life_span0.74441405
81MP0005535_abnormal_body_temperature0.72464771
82MP0002971_abnormal_brown_adipose0.70731188
83MP0003279_aneurysm0.70502223
84MP0002132_abnormal_respiratory_system0.70416009
85MP0004043_abnormal_pH_regulation0.69272374
86MP0002998_abnormal_bone_remodeling0.68144757
87MP0005334_abnormal_fat_pad0.67172265
88MP0004130_abnormal_muscle_cell0.64095051
89* MP0002136_abnormal_kidney_physiology0.63571301
90MP0000467_abnormal_esophagus_morphology0.63478471
91MP0003690_abnormal_glial_cell0.63118349
92MP0002928_abnormal_bile_duct0.62938770
93MP0000371_diluted_coat_color0.62678695
94MP0005266_abnormal_metabolism0.62219473
95MP0003329_amyloid_beta_deposits0.62022164
96MP0009278_abnormal_bone_marrow0.61861746
97MP0005257_abnormal_intraocular_pressure0.60912552
98MP0002933_joint_inflammation0.60347476
99MP0002060_abnormal_skin_morphology0.59012275
100MP0009053_abnormal_anal_canal0.58951237
101MP0005397_hematopoietic_system_phenotyp0.58634975
102MP0001545_abnormal_hematopoietic_system0.58634975
103MP0009931_abnormal_skin_appearance0.58565476
104MP0000733_abnormal_muscle_development0.58460631
105MP0005501_abnormal_skin_physiology0.58213533
106MP0006035_abnormal_mitochondrial_morpho0.57759258
107MP0010155_abnormal_intestine_physiology0.57030191
108MP0002396_abnormal_hematopoietic_system0.56844716
109MP0001958_emphysema0.55390792
110MP0003303_peritoneal_inflammation0.55192658
111MP0000639_abnormal_adrenal_gland0.52488479
112MP0005395_other_phenotype0.52465517
113MP0005448_abnormal_energy_balance0.51598950
114MP0003638_abnormal_response/metabolism_0.48977464
115MP0005464_abnormal_platelet_physiology0.48166530
116MP0003724_increased_susceptibility_to0.44741543
117MP0005058_abnormal_lysosome_morphology0.44161959
118MP0002822_catalepsy0.44127734
119MP0003953_abnormal_hormone_level0.43732420
120MP0005666_abnormal_adipose_tissue0.43445755
121MP0003718_maternal_effect0.43108126
122MP0008874_decreased_physiological_sensi0.42759304
123MP0002168_other_aberrant_phenotype0.40237429
124MP0009672_abnormal_birth_weight0.39149497
125MP0004782_abnormal_surfactant_physiolog0.38906707
126MP0003075_altered_response_to0.38767162
127MP0000230_abnormal_systemic_arterial0.38520608
128MP0004381_abnormal_hair_follicle0.36749687
129MP0005166_decreased_susceptibility_to0.36749489
130MP0003436_decreased_susceptibility_to0.36651106
131* MP0001765_abnormal_ion_homeostasis0.36590226
132MP0002837_dystrophic_cardiac_calcinosis0.35929885
133MP0008872_abnormal_physiological_respon0.35637024
134* MP0008873_increased_physiological_sensi0.34681590
135MP0002796_impaired_skin_barrier0.34294690
136MP0009384_cardiac_valve_regurgitation0.32098477
137MP0005248_abnormal_Harderian_gland0.32025061
138MP0009115_abnormal_fat_cell0.31564222
139MP0000579_abnormal_nail_morphology0.31084956
140MP0004147_increased_porphyrin_level0.29870859
141MP0002970_abnormal_white_adipose0.29647172
142MP0002135_abnormal_kidney_morphology0.29609155
143MP0004264_abnormal_extraembryonic_tissu0.28636675
144MP0006082_CNS_inflammation0.28635060
145MP0003300_gastrointestinal_ulcer0.27313622
146MP0000249_abnormal_blood_vessel0.27282025
147MP0001853_heart_inflammation0.26837943
148MP0001243_abnormal_dermal_layer0.26679357

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.25415286
2Intrahepatic cholestasis (HP:0001406)7.11782160
3Deep venous thrombosis (HP:0002625)6.99490775
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46828760
5Prolonged partial thromboplastin time (HP:0003645)6.17678916
6Xanthomatosis (HP:0000991)6.08053936
7Hypobetalipoproteinemia (HP:0003563)5.98948812
8Hyperlipoproteinemia (HP:0010980)5.18422045
9Complement deficiency (HP:0004431)5.12176509
10Hyperammonemia (HP:0001987)4.62784676
11Joint hemorrhage (HP:0005261)4.59649967
12Hyperglycinemia (HP:0002154)4.51847733
13Hypolipoproteinemia (HP:0010981)4.48387797
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46520824
15Ketosis (HP:0001946)4.41694085
16Epidermoid cyst (HP:0200040)4.29431612
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.25253819
18Hyperglycinuria (HP:0003108)4.23060411
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20900468
20Abnormality of the common coagulation pathway (HP:0010990)4.20186186
21Abnormality of glycine metabolism (HP:0010895)4.13511301
22Abnormality of serine family amino acid metabolism (HP:0010894)4.13511301
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.08841175
24Abnormality of methionine metabolism (HP:0010901)4.07070433
25Fat malabsorption (HP:0002630)4.02262684
26Hypoalphalipoproteinemia (HP:0003233)3.91541115
27Hypoglycemic coma (HP:0001325)3.85347649
28Abnormality of pyrimidine metabolism (HP:0004353)3.74266612
29Abnormality of complement system (HP:0005339)3.70983740
30Conjugated hyperbilirubinemia (HP:0002908)3.66985276
31Abnormality of the intrinsic pathway (HP:0010989)3.57984718
32Broad face (HP:0000283)3.54857809
33Abnormality of fatty-acid metabolism (HP:0004359)3.43317263
34Hypercholesterolemia (HP:0003124)3.37746040
35Hyperbilirubinemia (HP:0002904)3.35672952
36Abnormality of nucleobase metabolism (HP:0010932)3.32554538
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28391763
38Ketoacidosis (HP:0001993)3.26206068
39Delayed CNS myelination (HP:0002188)3.24506958
40Gout (HP:0001997)3.20958151
41Abnormality of purine metabolism (HP:0004352)3.11698502
42Abnormality of serum amino acid levels (HP:0003112)3.09646839
43Hepatocellular carcinoma (HP:0001402)3.05738358
44Steatorrhea (HP:0002570)2.99232638
45Thin bony cortex (HP:0002753)2.87557096
46Metabolic acidosis (HP:0001942)2.87433839
47Hypochromic microcytic anemia (HP:0004840)2.83547936
48Cervical subluxation (HP:0003308)2.80777077
49Myocardial infarction (HP:0001658)2.79693385
50Vascular calcification (HP:0004934)2.75767250
51Spontaneous abortion (HP:0005268)2.75389020
52Dicarboxylic aciduria (HP:0003215)2.72170895
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72170895
54Cerebral aneurysm (HP:0004944)2.71687711
55Lethargy (HP:0001254)2.70540151
56Systemic lupus erythematosus (HP:0002725)2.68141286
57J-shaped sella turcica (HP:0002680)2.66733541
58Abnormality of the Achilles tendon (HP:0005109)2.65286276
59Ulnar bowing (HP:0003031)2.63259699
60Mucopolysacchariduria (HP:0008155)2.62569993
61Urinary glycosaminoglycan excretion (HP:0003541)2.62569993
62Skin nodule (HP:0200036)2.62245160
63Flat acetabular roof (HP:0003180)2.61460360
64Obstructive sleep apnea (HP:0002870)2.61022085
65Biconcave vertebral bodies (HP:0004586)2.57408991
66Acanthocytosis (HP:0001927)2.57083289
67Generalized aminoaciduria (HP:0002909)2.48630952
68Spastic diplegia (HP:0001264)2.46830848
69Hypoglycemic seizures (HP:0002173)2.46534053
70Irritability (HP:0000737)2.43970863
71Cardiovascular calcification (HP:0011915)2.43913568
72Cerebral edema (HP:0002181)2.42993710
73Abnormality of polysaccharide metabolism (HP:0011012)2.41468679
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41468679
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41468679
76Abnormal gallbladder morphology (HP:0012437)2.41442268
77Neonatal onset (HP:0003623)2.40222924
78Reticulocytosis (HP:0001923)2.36284427
79Cholelithiasis (HP:0001081)2.35772441
80Malnutrition (HP:0004395)2.35695666
81Protrusio acetabuli (HP:0003179)2.35678755
82Mitral stenosis (HP:0001718)2.32378808
83Abnormal gallbladder physiology (HP:0012438)2.30591208
84Cholecystitis (HP:0001082)2.30591208
85Glomerulonephritis (HP:0000099)2.29774431
86Enlarged kidneys (HP:0000105)2.29761760
87Nephritis (HP:0000123)2.27122866
88Sensorimotor neuropathy (HP:0007141)2.26863872
89Asymmetry of the thorax (HP:0001555)2.26471290
90Alkalosis (HP:0001948)2.25647081
91Late onset (HP:0003584)2.24289577
92Proximal tubulopathy (HP:0000114)2.24127730
93Vomiting (HP:0002013)2.22763839
94Hyperacusis (HP:0010780)2.22629037
95Dysostosis multiplex (HP:0000943)2.22281622
96Stridor (HP:0010307)2.21174810
97Recurrent gram-negative bacterial infections (HP:0005420)2.20899740
98Rickets (HP:0002748)2.19095676
99Increased purine levels (HP:0004368)2.17804434
100Hyperuricemia (HP:0002149)2.17804434
101Abnormality of the thoracic spine (HP:0100711)2.16720141
102Esophageal varix (HP:0002040)2.15835500
103Pancreatitis (HP:0001733)2.15374547
104Lymphangioma (HP:0100764)2.14211811
105Purpura (HP:0000979)2.14007859
106Hydroxyprolinuria (HP:0003080)2.10216003
107Abnormality of proline metabolism (HP:0010907)2.10216003
108Amyloidosis (HP:0011034)2.09485181
109Brushfield spots (HP:0001088)2.08098135
110Abnormal enzyme/coenzyme activity (HP:0012379)2.05485081
111Menorrhagia (HP:0000132)2.05397410
112Bronchomalacia (HP:0002780)2.03948856
113Opisthotonus (HP:0002179)2.03734843
114Abnormality of urine glucose concentration (HP:0011016)2.03169068
115Glycosuria (HP:0003076)2.03169068
116Achilles tendon contracture (HP:0001771)2.03081429
117Gingival bleeding (HP:0000225)2.03068537
118Thrombophlebitis (HP:0004418)2.02465657
119Poikilocytosis (HP:0004447)2.02335951
120Abnormality of the gallbladder (HP:0005264)2.00417548
121Hypertriglyceridemia (HP:0002155)1.99909556
122Hyperinsulinemic hypoglycemia (HP:0000825)1.99891836
123Hypophosphatemic rickets (HP:0004912)1.94057088
124Aneurysm (HP:0002617)1.93637306
125Hemorrhage of the eye (HP:0011885)1.91156170
126Colitis (HP:0002583)1.87809969
127Abnormality of transition element cation homeostasis (HP:0011030)1.86686212
128Abnormality of carpal bone ossification (HP:0006257)1.86603623
129Abnormal cartilage morphology (HP:0002763)1.85594643
130Abnormality of iron homeostasis (HP:0011031)1.84066713
131Abnormality of the fingertips (HP:0001211)1.83608958
132Neonatal hypoglycemia (HP:0001998)1.83237548
133Disproportionate tall stature (HP:0001519)1.82267252
134Renal cortical cysts (HP:0000803)1.81882380
135Elevated alkaline phosphatase (HP:0003155)1.81084696
136Vertebral compression fractures (HP:0002953)1.80635105
137Impaired platelet aggregation (HP:0003540)1.80330520
138Abnormal platelet function (HP:0011869)1.80330520
139Thoracic kyphosis (HP:0002942)1.79111418
140Increased serum ferritin (HP:0003281)1.77869131
141Blue sclerae (HP:0000592)1.77186942
142Self-mutilation (HP:0000742)1.76513195
143Abnormality of alkaline phosphatase activity (HP:0004379)1.74221994
144Upper limb amyotrophy (HP:0009129)1.73144520
145Distal upper limb amyotrophy (HP:0007149)1.73144520
146Abnormal ossification of hand bones (HP:0005921)1.72694429
147Advanced eruption of teeth (HP:0006288)1.71101941
148Sparse lateral eyebrow (HP:0005338)1.70300881
149Distal lower limb amyotrophy (HP:0008944)1.69604198
150Short nail (HP:0001799)1.64708526
151Increased connective tissue (HP:0009025)1.63942339
152Deformed sella turcica (HP:0002681)1.62394432
153Hypophosphatemia (HP:0002148)1.62232880
154Epistaxis (HP:0000421)1.59144595
155Premature skin wrinkling (HP:0100678)1.58423102
156Seborrheic dermatitis (HP:0001051)1.57160539
157Bifid scrotum (HP:0000048)1.56987876
158Visceral angiomatosis (HP:0100761)1.54072990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.20473935
2FGFR44.48340040
3SIK14.32026073
4ERN14.25166621
5INSRR3.08161858
6TAOK33.07654733
7ERBB42.86670719
8EEF2K2.76191921
9SMG12.66579822
10MST1R2.30896571
11CDK122.28953296
12MAP2K42.19258604
13EPHA22.11822030
14PRPF4B2.07384843
15MAPK111.95540742
16PKN21.94879529
17FLT31.76500806
18PIK3CG1.75403418
19TRIB31.66674877
20TYK21.61741880
21LATS11.60269791
22TNK21.52885520
23PTK61.49936516
24PRKD31.47579571
25ABL21.46182104
26DAPK21.40612572
27PDGFRA1.40311351
28MARK21.38661706
29FRK1.35698738
30NEK91.33549682
31STK38L1.33162228
32AKT31.31598304
33MAP4K11.31460445
34PRKD21.30725908
35MAP3K71.28964235
36WNK41.27974608
37TTN1.22706220
38JAK21.22027886
39KDR1.21467601
40FGFR21.19325591
41PRKAA21.16885997
42PINK11.16260652
43GRK61.15819909
44TAOK11.14697907
45WNK31.07714762
46MAP2K31.05420743
47MAP3K141.02478777
48EPHB11.01829113
49ERBB21.01083993
50MAPK150.99876535
51TBK10.98801994
52ZAP700.98266765
53CDC42BPA0.97720356
54JAK10.97019762
55MAP3K100.92371288
56PRKCZ0.92047452
57MAPK40.91889028
58MAP3K30.91285275
59MET0.89198104
60SIK20.85301544
61RPS6KA20.85029162
62DYRK1B0.81740390
63GSK3A0.81162788
64SGK30.79866644
65IRAK30.78365908
66MAPK120.77740925
67MAP3K110.77339821
68OXSR10.75620920
69PRKACG0.75215716
70TIE10.75132952
71PRKAA10.73890540
72CAMKK10.71710691
73LMTK20.71344503
74CDK60.70717839
75CAMK1D0.69071243
76PAK40.67749882
77CSK0.67182843
78HIPK20.66393206
79RPS6KL10.66060062
80RPS6KC10.66060062
81BLK0.65557827
82SGK4940.65238663
83SGK2230.65238663
84CDK70.64704932
85EPHA30.64693129
86CAMK2G0.64224394
87TGFBR20.63455902
88PTK20.61148271
89RIPK10.60351994
90SGK20.59775913
91PDPK10.58655094
92TYRO30.56745382
93MAP2K60.55198281
94RIPK40.53880523
95MAPKAPK30.53748861
96IKBKE0.52632573
97BMX0.51738350
98CHUK0.51231628
99KSR20.50713683
100MAPK70.49996870
101CSNK1G10.48871896
102PRKCQ0.48646087
103CSF1R0.48393377
104DDR20.47953549
105IRAK40.47024282
106RPS6KA60.46964801
107FGFR30.46901107
108PDGFRB0.45378094
109PDK30.41951876
110PDK40.41951876
111MAP3K50.40572481
112ICK0.40434114
113PKN10.39631303
114TAOK20.39291471
115GRK10.39236413
116IGF1R0.39161504
117MTOR0.38343602
118CDK40.36873948
119MAP3K130.36638716
120PRKCG0.35809477
121MAP3K20.35529610
122RPS6KB20.35396797
123MAP2K10.35161174
124BTK0.34807678
125JAK30.34767965
126PDK10.34636298
127MAPK80.33351272
128NTRK10.31906583
129EGFR0.31642370
130CAMK1G0.31446218
131RET0.31411701
132WNK10.31321352
133PIM20.31085133
134CAMK40.30902865
135BRD40.30782578
136MAP3K60.30736036
137RPS6KA10.30516380
138EPHA40.30417214
139PAK20.29845956
140MAPK30.29137499
141MELK0.28766375
142IRAK10.27132114
143MAP3K10.26792423
144PRKCA0.26654345
145MAP2K20.26374144
146STK380.26021269
147NEK10.25845445
148PBK0.24785409
149IRAK20.23995477

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.38411673
2Nitrogen metabolism_Homo sapiens_hsa009103.51774110
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.46604887
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31903672
5Other glycan degradation_Homo sapiens_hsa005113.02222412
6Arginine biosynthesis_Homo sapiens_hsa002202.96707298
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70872740
8Tryptophan metabolism_Homo sapiens_hsa003802.69345290
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61088548
10Complement and coagulation cascades_Homo sapiens_hsa046102.60148356
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55078770
12Fatty acid degradation_Homo sapiens_hsa000712.49248985
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.44723286
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39956012
15Butanoate metabolism_Homo sapiens_hsa006502.30337034
16Peroxisome_Homo sapiens_hsa041462.14149853
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09612730
18Propanoate metabolism_Homo sapiens_hsa006402.00721091
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.89378504
20Chemical carcinogenesis_Homo sapiens_hsa052041.88907983
21Histidine metabolism_Homo sapiens_hsa003401.87466718
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86350709
23PPAR signaling pathway_Homo sapiens_hsa033201.82939254
24Fatty acid metabolism_Homo sapiens_hsa012121.80948743
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.74648619
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74609402
27beta-Alanine metabolism_Homo sapiens_hsa004101.73139213
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71164713
29Retinol metabolism_Homo sapiens_hsa008301.64628018
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63482171
31Staphylococcus aureus infection_Homo sapiens_hsa051501.62104715
32Selenocompound metabolism_Homo sapiens_hsa004501.59930473
33Caffeine metabolism_Homo sapiens_hsa002321.59836083
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58204581
35Bile secretion_Homo sapiens_hsa049761.54141793
36Phenylalanine metabolism_Homo sapiens_hsa003601.52510875
37Sulfur metabolism_Homo sapiens_hsa009201.47003717
38Pyruvate metabolism_Homo sapiens_hsa006201.45969211
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40106274
40Tyrosine metabolism_Homo sapiens_hsa003501.36874987
41Starch and sucrose metabolism_Homo sapiens_hsa005001.32470945
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.29786189
43Fatty acid elongation_Homo sapiens_hsa000621.27719881
44Folate biosynthesis_Homo sapiens_hsa007901.23677817
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.20574794
46ABC transporters_Homo sapiens_hsa020101.19542496
47Steroid biosynthesis_Homo sapiens_hsa001001.18624245
48Biosynthesis of amino acids_Homo sapiens_hsa012301.18527749
49Carbon metabolism_Homo sapiens_hsa012001.16640228
50Acute myeloid leukemia_Homo sapiens_hsa052211.14118348
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.09904525
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09627480
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07666674
54Fat digestion and absorption_Homo sapiens_hsa049751.07566953
55Notch signaling pathway_Homo sapiens_hsa043301.07290518
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04735691
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04279621
58Arginine and proline metabolism_Homo sapiens_hsa003301.00797403
59Vitamin digestion and absorption_Homo sapiens_hsa049770.96481587
60Sulfur relay system_Homo sapiens_hsa041220.95922638
61Chronic myeloid leukemia_Homo sapiens_hsa052200.94165972
62Non-small cell lung cancer_Homo sapiens_hsa052230.92355160
63Vitamin B6 metabolism_Homo sapiens_hsa007500.89061832
64Lysine degradation_Homo sapiens_hsa003100.86770795
65mTOR signaling pathway_Homo sapiens_hsa041500.83565791
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83237609
67VEGF signaling pathway_Homo sapiens_hsa043700.79115248
68One carbon pool by folate_Homo sapiens_hsa006700.74335297
69Glutathione metabolism_Homo sapiens_hsa004800.73896795
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73430866
71Glycerolipid metabolism_Homo sapiens_hsa005610.69608590
72Bladder cancer_Homo sapiens_hsa052190.64955712
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63950101
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61579959
75Endometrial cancer_Homo sapiens_hsa052130.59133302
76Pentose phosphate pathway_Homo sapiens_hsa000300.58688184
77Choline metabolism in cancer_Homo sapiens_hsa052310.55453267
78Sphingolipid metabolism_Homo sapiens_hsa006000.54501039
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53336930
80Pancreatic cancer_Homo sapiens_hsa052120.52959122
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51676714
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48965505
83Metabolic pathways_Homo sapiens_hsa011000.47836504
84Pertussis_Homo sapiens_hsa051330.47120739
85Fatty acid biosynthesis_Homo sapiens_hsa000610.46527362
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45853764
87Prolactin signaling pathway_Homo sapiens_hsa049170.45584817
88Thyroid cancer_Homo sapiens_hsa052160.42435491
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41613099
90Prostate cancer_Homo sapiens_hsa052150.39745080
91Inositol phosphate metabolism_Homo sapiens_hsa005620.38662427
92Amoebiasis_Homo sapiens_hsa051460.38486424
93ErbB signaling pathway_Homo sapiens_hsa040120.38399519
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.38312309
95B cell receptor signaling pathway_Homo sapiens_hsa046620.37217129
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36647829
97Glioma_Homo sapiens_hsa052140.35861908
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34074942
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.34046880
100Renal cell carcinoma_Homo sapiens_hsa052110.33180101
101Prion diseases_Homo sapiens_hsa050200.30821708
102Fructose and mannose metabolism_Homo sapiens_hsa000510.26908506
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24869468
104Galactose metabolism_Homo sapiens_hsa000520.23873384
105Insulin resistance_Homo sapiens_hsa049310.23553100
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.22386447
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21023561
108Linoleic acid metabolism_Homo sapiens_hsa005910.17402551
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.13218897
110Glucagon signaling pathway_Homo sapiens_hsa049220.08931494
111AMPK signaling pathway_Homo sapiens_hsa041520.02339170
112Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2270384
113Lysosome_Homo sapiens_hsa04142-0.2254909
114Protein digestion and absorption_Homo sapiens_hsa04974-0.2171941
115African trypanosomiasis_Homo sapiens_hsa05143-0.2010419
116Mineral absorption_Homo sapiens_hsa04978-0.1954197
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1857056
118Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1820491
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1745761
120Hepatitis C_Homo sapiens_hsa05160-0.1629250
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1522956
122Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1493155
123Renin-angiotensin system_Homo sapiens_hsa04614-0.1475152
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1435944
125Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1289550
126Regulation of autophagy_Homo sapiens_hsa04140-0.1268872
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1098481
128Insulin signaling pathway_Homo sapiens_hsa04910-0.1051939
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0912228
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0895154
131Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0775807
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0166418

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