SLC26A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)8.64601650
2sarcomere organization (GO:0045214)7.98687635
3cardiac myofibril assembly (GO:0055003)7.23495486
4thyroid hormone metabolic process (GO:0042403)6.90185472
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.59602779
6myofibril assembly (GO:0030239)6.42974788
7cardiac muscle contraction (GO:0060048)5.98521479
8negative regulation of potassium ion transmembrane transport (GO:1901380)5.97440874
9plasma membrane repair (GO:0001778)5.92193137
10regulation of actin filament-based movement (GO:1903115)5.72307931
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.62308518
12tricarboxylic acid cycle (GO:0006099)5.46898045
13ventricular cardiac muscle cell action potential (GO:0086005)5.44981335
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.44551004
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.44191477
16cardiac muscle cell development (GO:0055013)5.34637099
17muscle filament sliding (GO:0030049)5.27860576
18actin-myosin filament sliding (GO:0033275)5.27860576
19adult heart development (GO:0007512)5.20100228
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.19890891
21cardiac cell development (GO:0055006)5.02769526
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.98507413
23ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.97115074
24actomyosin structure organization (GO:0031032)4.94277132
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.91216461
26regulation of relaxation of muscle (GO:1901077)4.89823808
27heart trabecula formation (GO:0060347)4.88520364
28cardiac muscle tissue morphogenesis (GO:0055008)4.88439464
29carnitine shuttle (GO:0006853)4.86183015
30pyrimidine nucleobase catabolic process (GO:0006208)4.82762307
31postsynaptic membrane organization (GO:0001941)4.77915244
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.77300800
33cell communication involved in cardiac conduction (GO:0086065)4.72971575
34cardiac muscle hypertrophy (GO:0003300)4.52368585
35striated muscle contraction (GO:0006941)4.50655267
36fatty acid transmembrane transport (GO:1902001)4.45839029
37neuron recognition (GO:0008038)4.45434348
38regulation of the force of heart contraction (GO:0002026)4.44893564
39axonal fasciculation (GO:0007413)4.42810351
40regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.40582791
41actin-mediated cell contraction (GO:0070252)4.38682655
42regulation of skeletal muscle contraction (GO:0014819)4.35764751
43regulation of cardiac muscle cell contraction (GO:0086004)4.33113551
44regulation of striated muscle contraction (GO:0006942)4.32946718
45regulation of sarcomere organization (GO:0060297)4.31788076
46muscle tissue morphogenesis (GO:0060415)4.31568372
47striated muscle hypertrophy (GO:0014897)4.26781923
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16656906
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.14806638
50behavioral response to nicotine (GO:0035095)4.12172115
51cell migration in hindbrain (GO:0021535)4.11792442
52cerebral cortex radially oriented cell migration (GO:0021799)4.11371476
53regulation of membrane repolarization (GO:0060306)4.08553238
54regulation of acyl-CoA biosynthetic process (GO:0050812)4.06599153
55cell communication by electrical coupling (GO:0010644)4.02062480
56regulation of cell communication by electrical coupling (GO:0010649)3.97667972
572-oxoglutarate metabolic process (GO:0006103)3.97595693
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.96200548
59positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.93565710
60neuronal ion channel clustering (GO:0045161)3.87752891
61dendritic spine morphogenesis (GO:0060997)3.87580581
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.87382326
63membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83721147
64regulation of cardiac muscle contraction (GO:0055117)3.78668954
65cardiac muscle cell action potential involved in contraction (GO:0086002)3.77808220
66muscle hypertrophy (GO:0014896)3.76499760
67NADH metabolic process (GO:0006734)3.74675152
68nucleobase catabolic process (GO:0046113)3.74337920
69presynaptic membrane assembly (GO:0097105)3.74167837
70synaptic vesicle exocytosis (GO:0016079)3.72750074
71neuron cell-cell adhesion (GO:0007158)3.71246076
72cardiac muscle cell action potential (GO:0086001)3.71061936
73neurotransmitter-gated ion channel clustering (GO:0072578)3.70828335
74establishment of mitochondrion localization (GO:0051654)3.70504745
75regulation of short-term neuronal synaptic plasticity (GO:0048172)3.69796252
76positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.68870040
77protein localization to synapse (GO:0035418)3.68624003
78oxygen transport (GO:0015671)3.68245528
79regulation of coenzyme metabolic process (GO:0051196)3.68095418
80regulation of cofactor metabolic process (GO:0051193)3.68095418
81neuronal action potential propagation (GO:0019227)3.67939927
82presynaptic membrane organization (GO:0097090)3.64974900
83negative regulation of potassium ion transport (GO:0043267)3.64594720
84carnitine transmembrane transport (GO:1902603)3.62405599
85aspartate family amino acid catabolic process (GO:0009068)3.61457117
86heart process (GO:0003015)3.60948529
87heart contraction (GO:0060047)3.60948529
88synaptic vesicle maturation (GO:0016188)3.59908638
89response to parathyroid hormone (GO:0071107)3.58429138
90central nervous system projection neuron axonogenesis (GO:0021952)3.58404948
91regulation of heart rate (GO:0002027)3.53600318
92relaxation of cardiac muscle (GO:0055119)3.52154032
93auditory behavior (GO:0031223)3.52100749
94synaptic vesicle docking involved in exocytosis (GO:0016081)3.47621866
95regulation of heart contraction (GO:0008016)3.42877701
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.41121494
97positive regulation of cation channel activity (GO:2001259)3.38977781
98glutamate secretion (GO:0014047)3.38109574
99lysine catabolic process (GO:0006554)3.38016831
100lysine metabolic process (GO:0006553)3.38016831
101actin filament-based movement (GO:0030048)3.37703020
102regulation of ATPase activity (GO:0043462)3.37456225
103regulation of ATP catabolic process (GO:1903289)3.37456225
104regulation of sequestering of triglyceride (GO:0010889)3.36762976
105negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.36483586
106layer formation in cerebral cortex (GO:0021819)3.36286186
107central nervous system myelination (GO:0022010)3.35311386
108axon ensheathment in central nervous system (GO:0032291)3.35311386
109regulation of cardioblast differentiation (GO:0051890)3.35242389
110regulation of synapse structural plasticity (GO:0051823)3.34203743
111carnitine transport (GO:0015879)3.33049152
112amino-acid betaine transport (GO:0015838)3.33049152
113thyroid gland development (GO:0030878)3.32654797
114transmission of nerve impulse (GO:0019226)3.32480456
115regulation of fatty acid oxidation (GO:0046320)3.31710259
116negative regulation of striated muscle cell apoptotic process (GO:0010664)3.28181091
117cardiac muscle adaptation (GO:0014887)3.28093415
118cardiac muscle hypertrophy in response to stress (GO:0014898)3.28093415
119muscle hypertrophy in response to stress (GO:0003299)3.28093415
120cardiac conduction (GO:0061337)3.25599904
121positive regulation of heart contraction (GO:0045823)3.25000883
122regulation of heart rate by cardiac conduction (GO:0086091)3.23067506
123positive regulation of glycogen biosynthetic process (GO:0045725)3.22351346
124locomotory exploration behavior (GO:0035641)3.22022105
125negative regulation of protein localization to cell surface (GO:2000009)3.22000590
126positive regulation of synapse maturation (GO:0090129)3.19814368
127creatine metabolic process (GO:0006600)3.18587741
128ionotropic glutamate receptor signaling pathway (GO:0035235)3.17803299
129synaptic transmission, cholinergic (GO:0007271)3.16975885
130synaptic transmission, glutamatergic (GO:0035249)3.16420332
131axon extension (GO:0048675)3.16118288
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15031011
133venous blood vessel morphogenesis (GO:0048845)3.14615311
134positive regulation of heart rate (GO:0010460)3.14604020
135oxaloacetate metabolic process (GO:0006107)3.13569987
136mechanosensory behavior (GO:0007638)3.10921933
137spinal cord development (GO:0021510)3.10629340
138fatty acid beta-oxidation (GO:0006635)3.08261259
139regulation of sulfur metabolic process (GO:0042762)3.07638108
140regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07536318
141establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07016731
142mitochondrion transport along microtubule (GO:0047497)3.07016731
143head development (GO:0060322)3.04789312
144vocalization behavior (GO:0071625)3.01960305
145positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99300041
146neuron projection extension (GO:1990138)2.98593417
147positive regulation of dendritic spine development (GO:0060999)2.98504805
148regulation of glutamate receptor signaling pathway (GO:1900449)2.96834327
149retinal ganglion cell axon guidance (GO:0031290)2.96460108
150cerebral cortex neuron differentiation (GO:0021895)2.93971000
151protein localization to cilium (GO:0061512)2.93418503
152synapse assembly (GO:0007416)2.91744031
153cell-cell junction maintenance (GO:0045217)2.90580870
154regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89824295
155axon extension involved in axon guidance (GO:0048846)2.89236381
156neuron projection extension involved in neuron projection guidance (GO:1902284)2.89236381
157central nervous system neuron axonogenesis (GO:0021955)2.87180791
158response to auditory stimulus (GO:0010996)2.86809662
159regulation of synaptic vesicle exocytosis (GO:2000300)2.86451616
160neurotransmitter secretion (GO:0007269)2.86198425
161positive regulation of dendritic spine morphogenesis (GO:0061003)2.85786240
162neuron fate determination (GO:0048664)2.83579422
163spinal cord association neuron differentiation (GO:0021527)2.80722901
164neurofilament cytoskeleton organization (GO:0060052)2.79107258
165neuromuscular synaptic transmission (GO:0007274)2.78519695
166membrane depolarization during action potential (GO:0086010)2.78447923
167positive regulation of synapse assembly (GO:0051965)2.76847970
168exploration behavior (GO:0035640)2.76774362
169positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74263795
170negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73272899
171dendritic spine organization (GO:0097061)2.70249544
172regulation of synapse maturation (GO:0090128)2.68810501
173regulation of respiratory system process (GO:0044065)2.68797602
174regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66163933
175regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65767455
176snRNA transcription (GO:0009301)2.65216487
177cell junction maintenance (GO:0034331)2.64345209
178ganglion development (GO:0061548)2.63602095
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.62429024
180neuron-neuron synaptic transmission (GO:0007270)2.62186166
181glutamate receptor signaling pathway (GO:0007215)2.60977272
182gamma-aminobutyric acid transport (GO:0015812)2.60823304
183brain morphogenesis (GO:0048854)2.58034553
184dendrite morphogenesis (GO:0048813)2.58006429
185cellular potassium ion homeostasis (GO:0030007)2.56060772
186short-term memory (GO:0007614)2.55414052
187regulation of axon guidance (GO:1902667)2.54328439
188cranial nerve morphogenesis (GO:0021602)2.53391347
189regulation of dendritic spine morphogenesis (GO:0061001)2.52080763
190positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49219631
191camera-type eye morphogenesis (GO:0048593)2.49188535
192synaptic vesicle endocytosis (GO:0048488)2.48482538
193positive regulation of membrane potential (GO:0045838)2.48055223
194regulation of axon extension involved in axon guidance (GO:0048841)2.47622069
195membrane depolarization (GO:0051899)2.47447216
196negative regulation of axon extension (GO:0030517)2.45576597
197synapse organization (GO:0050808)2.45537607
198adult walking behavior (GO:0007628)2.45425726
199positive regulation of dendrite morphogenesis (GO:0050775)2.44841973
200nephron tubule morphogenesis (GO:0072078)2.43122456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.36243379
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.69502998
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.68163488
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45487172
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.23656608
6TBX20_22328084_ChIP-Seq_HEART_Mouse3.20304002
7TBX20_22080862_ChIP-Seq_HEART_Mouse3.20304002
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95534244
9ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.89831161
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.85507036
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72942482
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.59961312
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.59072047
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54338592
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53285397
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.52489696
17REST_21632747_ChIP-Seq_MESCs_Mouse2.49780674
18GBX2_23144817_ChIP-Seq_PC3_Human2.42340922
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37841494
20PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36998559
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36335407
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35128836
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28365973
24EZH2_22144423_ChIP-Seq_EOC_Human2.25210377
25ERG_21242973_ChIP-ChIP_JURKAT_Human2.19949979
26ESR2_21235772_ChIP-Seq_MCF-7_Human2.17914188
27RXR_22158963_ChIP-Seq_LIVER_Mouse2.17248777
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15950225
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09965427
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.06179337
31LXR_22158963_ChIP-Seq_LIVER_Mouse2.06080441
32BP1_19119308_ChIP-ChIP_Hs578T_Human2.03855305
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02169356
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00506227
35MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.00339828
36REST_18959480_ChIP-ChIP_MESCs_Mouse2.00213160
37DROSHA_22980978_ChIP-Seq_HELA_Human1.97959858
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.97883950
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95402813
40ZNF263_19887448_ChIP-Seq_K562_Human1.89689850
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88296982
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.86371703
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.81115352
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74754400
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62631556
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.62334135
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60148347
48RNF2_27304074_Chip-Seq_NSC_Mouse1.59888593
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58335259
50CLOCK_20551151_ChIP-Seq_293T_Human1.55913705
51KDM2B_26808549_Chip-Seq_DND41_Human1.50299489
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49429209
53* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49340546
54* LXR_22292898_ChIP-Seq_THP-1_Human1.49260555
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48910355
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48123844
57* CTCF_27219007_Chip-Seq_Bcells_Human1.48013585
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47703986
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.44741058
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.43233881
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41294339
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.40824674
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39136278
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35146274
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.34609413
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34208752
67RACK7_27058665_Chip-Seq_MCF-7_Human1.33229015
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31824347
69GATA1_19941826_ChIP-Seq_K562_Human1.31741697
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31532624
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29714017
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28430994
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28285826
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27119811
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26397321
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25880251
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25656737
78KDM2B_26808549_Chip-Seq_K562_Human1.25235431
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24825040
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22576974
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20767238
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20348147
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17851158
84TP63_22573176_ChIP-Seq_HFKS_Human1.16952827
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.11805192
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10835261
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10804664
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.10615197
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10065449
90SOX9_26525672_Chip-Seq_HEART_Mouse1.09525357
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08155695
92AR_21572438_ChIP-Seq_LNCaP_Human1.07119300
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06760959
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.06320717
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06009178
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05929525
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05598870
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.05446199
99P68_20966046_ChIP-Seq_HELA_Human1.04899846
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04128124
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04128124
102FOXA2_19822575_ChIP-Seq_HepG2_Human1.03937050
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02494296
104TET1_21490601_ChIP-Seq_MESCs_Mouse1.02415972
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.02051463
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01524429
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01524429
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01309650
109* RARB_27405468_Chip-Seq_BRAIN_Mouse1.01089995
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.00809791
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00703768
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00477145
113VDR_22108803_ChIP-Seq_LS180_Human1.00153851
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99930355
115KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99836849
116GATA1_22025678_ChIP-Seq_K562_Human0.99643231
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99387752
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99083395
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98269462
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97794134
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96385548
122GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96325607
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96161253
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95555558
125TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94958635
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94865676
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.94434603
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94257303
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93794358
130* TP53_23651856_ChIP-Seq_MEFs_Mouse0.93564353
131AR_19668381_ChIP-Seq_PC3_Human0.92845934
132SPI1_23127762_ChIP-Seq_K562_Human0.92647536
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92564479
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92368987
135SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91858172
136SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90930806
137GATA2_19941826_ChIP-Seq_K562_Human0.90601567
138NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90153938
139* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.90103217
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89581247
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.89125560
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89017901
143NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87886289
144TCF7_22412390_ChIP-Seq_EML_Mouse0.87606902
145OCT4_19829295_ChIP-Seq_ESCs_Human0.87165117
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87048865
147TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86719450
148CREB1_26743006_Chip-Seq_LNCaP_Human0.86696531
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86296126
150KLF4_19829295_ChIP-Seq_ESCs_Human0.86036934
151SOX3_22085726_ChIP-Seq_NPCs_Mouse0.85907925
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85707011
153* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85498917
154KDM2B_26808549_Chip-Seq_JURKAT_Human0.85426404
155STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84696577
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.83949915
157CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83227489
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82789163
159* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82469394
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82454680
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.81993232
162SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.80416547
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79582143
164SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.79029093
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.77828557
166MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.76942359
167SMAD4_21799915_ChIP-Seq_A2780_Human0.76423481
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75653134
169TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75343985

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.71164846
2MP0004084_abnormal_cardiac_muscle5.90344487
3MP0003646_muscle_fatigue5.39133690
4MP0004215_abnormal_myocardial_fiber4.78386921
5MP0000751_myopathy4.62265521
6MP0004036_abnormal_muscle_relaxation4.24376318
7MP0005330_cardiomyopathy3.81538810
8MP0000749_muscle_degeneration3.19436826
9MP0000778_abnormal_nervous_system3.11928641
10MP0003880_abnormal_central_pattern3.02189236
11MP0002972_abnormal_cardiac_muscle2.95171292
12MP0008775_abnormal_heart_ventricle2.84744349
13MP0004087_abnormal_muscle_fiber2.83797514
14MP0003137_abnormal_impulse_conducting2.77480656
15MP0003635_abnormal_synaptic_transmissio2.69166611
16MP0005423_abnormal_somatic_nervous2.65906622
17MP0005385_cardiovascular_system_phenoty2.61479767
18MP0001544_abnormal_cardiovascular_syste2.61479767
19MP0004270_analgesia2.60016040
20MP0006138_congestive_heart_failure2.54909607
21MP0006276_abnormal_autonomic_nervous2.51402257
22MP0010630_abnormal_cardiac_muscle2.50711889
23MP0005620_abnormal_muscle_contractility2.45424049
24MP0004484_altered_response_of2.43871127
25MP0000750_abnormal_muscle_regeneration2.36939046
26MP0006292_abnormal_olfactory_placode2.32828754
27MP0004130_abnormal_muscle_cell2.20794486
28MP0003828_pulmonary_edema2.18480601
29MP0002063_abnormal_learning/memory/cond2.17578795
30MP0002106_abnormal_muscle_physiology2.17337532
31MP0002735_abnormal_chemical_nociception2.11866954
32MP0003122_maternal_imprinting2.11177235
33MP0004510_myositis2.10796448
34MP0005499_abnormal_olfactory_system2.09872005
35MP0005394_taste/olfaction_phenotype2.09872005
36MP0004085_abnormal_heartbeat2.09131344
37MP0002734_abnormal_mechanical_nocicepti2.06721332
38MP0002269_muscular_atrophy2.05873800
39MP0003787_abnormal_imprinting1.96160871
40MP0002064_seizures1.85248581
41MP0008789_abnormal_olfactory_epithelium1.84679551
42MP0009745_abnormal_behavioral_response1.84679338
43MP0009379_abnormal_foot_pigmentation1.83443859
44MP0002272_abnormal_nervous_system1.82450056
45MP0010368_abnormal_lymphatic_system1.81296420
46MP0002736_abnormal_nociception_after1.78622827
47MP0002572_abnormal_emotion/affect_behav1.74143410
48MP0005369_muscle_phenotype1.73051553
49MP0001502_abnormal_circadian_rhythm1.72411754
50MP0002638_abnormal_pupillary_reflex1.71549892
51MP0001968_abnormal_touch/_nociception1.71228165
52MP0000955_abnormal_spinal_cord1.70518287
53MP0002184_abnormal_innervation1.69584187
54MP0000747_muscle_weakness1.68166936
55MP0001984_abnormal_olfaction1.67094697
56MP0001486_abnormal_startle_reflex1.65461528
57MP0002557_abnormal_social/conspecific_i1.65428033
58MP0000566_synostosis1.64835173
59MP0000049_abnormal_middle_ear1.64728590
60MP0000759_abnormal_skeletal_muscle1.64050793
61MP0006036_abnormal_mitochondrial_physio1.62084003
62MP0002733_abnormal_thermal_nociception1.60057161
63MP0002882_abnormal_neuron_morphology1.59332569
64MP0001970_abnormal_pain_threshold1.58626328
65MP0002332_abnormal_exercise_endurance1.57271473
66MP0002127_abnormal_cardiovascular_syste1.57004317
67MP0003221_abnormal_cardiomyocyte_apopto1.55309474
68MP0004233_abnormal_muscle_weight1.54107696
69MP0004811_abnormal_neuron_physiology1.51802678
70MP0004043_abnormal_pH_regulation1.50374224
71MP0005670_abnormal_white_adipose1.50295259
72MP0009046_muscle_twitch1.49276630
73MP0000534_abnormal_ureter_morphology1.48714610
74MP0002653_abnormal_ependyma_morphology1.47283487
75MP0003121_genomic_imprinting1.46571468
76MP0002067_abnormal_sensory_capabilities1.42669334
77MP0005165_increased_susceptibility_to1.39999752
78MP0002822_catalepsy1.39719594
79MP0005666_abnormal_adipose_tissue1.35093218
80MP0005167_abnormal_blood-brain_barrier1.35036209
81MP0002152_abnormal_brain_morphology1.33195043
82MP0002752_abnormal_somatic_nervous1.32899423
83MP0001440_abnormal_grooming_behavior1.32690231
84MP0004142_abnormal_muscle_tone1.32603716
85MP0006072_abnormal_retinal_apoptosis1.32078880
86MP0000631_abnormal_neuroendocrine_gland1.30391324
87MP0004885_abnormal_endolymph1.30253673
88MP0005551_abnormal_eye_electrophysiolog1.29486686
89MP0001529_abnormal_vocalization1.29176663
90MP0004145_abnormal_muscle_electrophysio1.28777023
91MP0003942_abnormal_urinary_system1.24182034
92MP0003861_abnormal_nervous_system1.22343674
93MP0005386_behavior/neurological_phenoty1.22082791
94MP0004924_abnormal_behavior1.22082791
95MP0002234_abnormal_pharynx_morphology1.19018809
96MP0003136_yellow_coat_color1.18337054
97MP0003950_abnormal_plasma_membrane1.16918882
98MP0001299_abnormal_eye_distance/1.16669724
99MP0001879_abnormal_lymphatic_vessel1.16493803
100MP0000681_abnormal_thyroid_gland1.16325479
101MP0000026_abnormal_inner_ear1.15359133
102MP0008569_lethality_at_weaning1.14334358
103MP0003567_abnormal_fetal_cardiomyocyte1.12560482
104MP0008877_abnormal_DNA_methylation1.12523101
105MP0003938_abnormal_ear_development1.12388499
106MP0003123_paternal_imprinting1.11141506
107MP0003890_abnormal_embryonic-extraembry1.10246316
108MP0000343_altered_response_to1.10004916
109MP0002066_abnormal_motor_capabilities/c1.08915691
110MP0000266_abnormal_heart_morphology1.07764375
111MP0001963_abnormal_hearing_physiology1.07351517
112MP0010030_abnormal_orbit_morphology1.05077795
113MP0004742_abnormal_vestibular_system1.02735521
114MP0001188_hyperpigmentation1.02491130
115MP0004133_heterotaxia1.01247617
116MP0002249_abnormal_larynx_morphology1.01223090
117MP0003385_abnormal_body_wall1.00620422
118MP0003879_abnormal_hair_cell1.00013564
119MP0000678_abnormal_parathyroid_gland0.98732202
120MP0004185_abnormal_adipocyte_glucose0.97674414
121MP0003279_aneurysm0.97013158
122MP0005646_abnormal_pituitary_gland0.94885737
123MP0005195_abnormal_posterior_eye0.93416230
124MP0003566_abnormal_cell_adhesion0.92771777
125MP0002116_abnormal_craniofacial_bone0.91217063
126MP0005623_abnormal_meninges_morphology0.87686093
127MP0005375_adipose_tissue_phenotype0.86027418
128MP0002128_abnormal_blood_circulation0.85384672
129MP0002751_abnormal_autonomic_nervous0.85360963
130MP0002909_abnormal_adrenal_gland0.85309059
131MP0001501_abnormal_sleep_pattern0.85261756
132MP0000230_abnormal_systemic_arterial0.85084766
133MP0005085_abnormal_gallbladder_physiolo0.82195404
134MP0010386_abnormal_urinary_bladder0.81026184
135MP0006035_abnormal_mitochondrial_morpho0.80667967
136MP0003634_abnormal_glial_cell0.80548226
137MP0005377_hearing/vestibular/ear_phenot0.78790992
138MP0003878_abnormal_ear_physiology0.78790992
139MP0001485_abnormal_pinna_reflex0.78771340
140MP0003119_abnormal_digestive_system0.78511507
141MP0002069_abnormal_eating/drinking_beha0.78510255
142MP0002233_abnormal_nose_morphology0.78339783
143MP0005319_abnormal_enzyme/_coenzyme0.77192433
144MP0005451_abnormal_body_composition0.76431645
145MP0003755_abnormal_palate_morphology0.76169460
146MP0000920_abnormal_myelination0.75639970
147MP0003633_abnormal_nervous_system0.75452803
148MP0000383_abnormal_hair_follicle0.74630383
149MP0005409_darkened_coat_color0.73968648
150MP0002229_neurodegeneration0.72858178
151MP0005253_abnormal_eye_physiology0.72631778
152MP0008961_abnormal_basal_metabolism0.71595845
153MP0002102_abnormal_ear_morphology0.70774786
154MP0002081_perinatal_lethality0.70757223
155MP0003705_abnormal_hypodermis_morpholog0.67785398
156MP0005266_abnormal_metabolism0.66779118
157MP0004272_abnormal_basement_membrane0.66062214
158MP0000767_abnormal_smooth_muscle0.63820062
159MP0005360_urolithiasis0.60942003
160MP0005584_abnormal_enzyme/coenzyme_acti0.59848105
161MP0002295_abnormal_pulmonary_circulatio0.59845888
162MP0008874_decreased_physiological_sensi0.59337037
163MP0002108_abnormal_muscle_morphology0.57610540
164MP0002925_abnormal_cardiovascular_devel0.54524354
165MP0009840_abnormal_foam_cell0.51493336
166MP0005595_abnormal_vascular_smooth0.49924560
167MP0005187_abnormal_penis_morphology0.49908716
168MP0002138_abnormal_hepatobiliary_system0.47735439
169MP0009643_abnormal_urine_homeostasis0.47609088
170MP0002078_abnormal_glucose_homeostasis0.46869931
171MP0010678_abnormal_skin_adnexa0.46854745
172MP0003806_abnormal_nucleotide_metabolis0.46336690
173MP0005332_abnormal_amino_acid0.46167149
174MP0002971_abnormal_brown_adipose0.45948476
175MP0003191_abnormal_cellular_cholesterol0.45818701
176MP0005535_abnormal_body_temperature0.45641169
177MP0002118_abnormal_lipid_homeostasis0.45555492
178MP0000249_abnormal_blood_vessel0.44913779
179MP0001958_emphysema0.40668026
180MP0005083_abnormal_biliary_tract0.40656329
181MP0008875_abnormal_xenobiotic_pharmacok0.38881921
182MP0000003_abnormal_adipose_tissue0.38256722
183MP0005365_abnormal_bile_salt0.37988517
184MP0001614_abnormal_blood_vessel0.37646637
185MP0009115_abnormal_fat_cell0.36966985
186MP0003303_peritoneal_inflammation0.36512228
187MP0003075_altered_response_to0.36420014
188MP0010329_abnormal_lipoprotein_level0.35939351
189MP0004859_abnormal_synaptic_plasticity0.35320268
190MP0001765_abnormal_ion_homeostasis0.33627413
191MP0004147_increased_porphyrin_level0.31043774

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.97447627
2Ventricular tachycardia (HP:0004756)6.95191129
3Muscle fiber splitting (HP:0003555)6.00030091
4Atrial fibrillation (HP:0005110)5.99680791
5Calf muscle hypertrophy (HP:0008981)5.88966882
6Myokymia (HP:0002411)5.76111333
7Primary atrial arrhythmia (HP:0001692)5.63153779
8Supraventricular tachycardia (HP:0004755)5.43975654
9Supraventricular arrhythmia (HP:0005115)5.36286584
10Exercise-induced myalgia (HP:0003738)5.30414454
11Right ventricular cardiomyopathy (HP:0011663)5.28532525
12Muscle hypertrophy of the lower extremities (HP:0008968)5.24523374
13Exercise-induced muscle cramps (HP:0003710)5.22435588
14Lipoatrophy (HP:0100578)5.03410669
15Syncope (HP:0001279)4.90531906
16Abnormality of the calf musculature (HP:0001430)4.82789451
17Hyporeflexia of lower limbs (HP:0002600)4.76697473
18Bundle branch block (HP:0011710)4.63570005
19Abnormality of the left ventricular outflow tract (HP:0011103)4.49913783
20Subaortic stenosis (HP:0001682)4.49913783
21Palpitations (HP:0001962)4.48923729
22Myoglobinuria (HP:0002913)4.30983687
23Prolonged QT interval (HP:0001657)4.26784100
24Dilated cardiomyopathy (HP:0001644)4.18724546
25Atrioventricular block (HP:0001678)4.13907895
26Increased connective tissue (HP:0009025)4.10798669
27Heart block (HP:0012722)4.02828058
28EMG: myopathic abnormalities (HP:0003458)4.02715716
29Asymmetric septal hypertrophy (HP:0001670)4.01939179
30Ventricular arrhythmia (HP:0004308)3.98715957
31Entropion (HP:0000621)3.97077348
32Goiter (HP:0000853)3.90109434
33Ventricular fibrillation (HP:0001663)3.82591538
34Difficulty running (HP:0009046)3.78404375
35Abnormal atrioventricular conduction (HP:0005150)3.74049101
36Focal motor seizures (HP:0011153)3.52426220
37Poikiloderma (HP:0001029)3.45813267
38Rhabdomyolysis (HP:0003201)3.25671890
39Type II lissencephaly (HP:0007260)3.21094730
40Myotonia (HP:0002486)3.16895570
41Difficulty climbing stairs (HP:0003551)3.16151765
42Focal seizures (HP:0007359)3.15593364
43Abnormal EKG (HP:0003115)3.10338368
44Testicular atrophy (HP:0000029)2.91486248
45Abnormality of DNA repair (HP:0003254)2.79140849
46Ketoacidosis (HP:0001993)2.75451767
47Abnormality of the aortic arch (HP:0012303)2.71762221
48Action tremor (HP:0002345)2.67056637
49Cerebellar dysplasia (HP:0007033)2.66997946
50Pili torti (HP:0003777)2.64158756
51Poor suck (HP:0002033)2.63336140
52Increased variability in muscle fiber diameter (HP:0003557)2.62253756
53Papilledema (HP:0001085)2.58366943
54Hypoglycemic coma (HP:0001325)2.56607823
55Distal lower limb muscle weakness (HP:0009053)2.54113410
56Left ventricular hypertrophy (HP:0001712)2.49334299
57Epileptic encephalopathy (HP:0200134)2.48769371
58Retinal dysplasia (HP:0007973)2.47185795
59Ketosis (HP:0001946)2.46628797
60Palmoplantar keratoderma (HP:0000982)2.45215867
61Limb-girdle muscle atrophy (HP:0003797)2.43638726
62Hepatic necrosis (HP:0002605)2.42799732
63Abnormality of midbrain morphology (HP:0002418)2.42161095
64Molar tooth sign on MRI (HP:0002419)2.42161095
65Dysmetric saccades (HP:0000641)2.41181980
66Abnormality of the labia minora (HP:0012880)2.40548257
67Spastic gait (HP:0002064)2.40029286
68Distal lower limb amyotrophy (HP:0008944)2.38625765
69Polycythemia (HP:0001901)2.37093674
70Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.36618835
71Lissencephaly (HP:0001339)2.36257837
72Drooling (HP:0002307)2.35409276
73Dicarboxylic aciduria (HP:0003215)2.35364275
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35364275
75Poor eye contact (HP:0000817)2.32677330
76Type 2 muscle fiber atrophy (HP:0003554)2.32055403
77Amblyopia (HP:0000646)2.30193368
78Abnormality of skeletal muscle fiber size (HP:0012084)2.30045858
79Atonic seizures (HP:0010819)2.29330440
80Abnormality of the corticospinal tract (HP:0002492)2.27300870
81Abnormality of fatty-acid metabolism (HP:0004359)2.26247902
82Areflexia of lower limbs (HP:0002522)2.24799422
83Polyphagia (HP:0002591)2.24779049
84Sudden cardiac death (HP:0001645)2.24317125
85Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24198017
86Short 4th metacarpal (HP:0010044)2.24198017
87Abnormal social behavior (HP:0012433)2.21437935
88Impaired social interactions (HP:0000735)2.21437935
89Urinary urgency (HP:0000012)2.18185113
90Broad metatarsal (HP:0001783)2.16667536
91Gait imbalance (HP:0002141)2.16161325
92Hypoplasia of the brainstem (HP:0002365)2.15674059
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.15674059
94Anomalous pulmonary venous return (HP:0010772)2.15320579
95Abnormal mitochondria in muscle tissue (HP:0008316)2.14008840
96Nephronophthisis (HP:0000090)2.12816131
97Cerebral edema (HP:0002181)2.12790635
98Muscle stiffness (HP:0003552)2.12254395
99Abnormality of the foot musculature (HP:0001436)2.10901209
100Oligodactyly (hands) (HP:0001180)2.10783272
101Sleep apnea (HP:0010535)2.10447544
102Abnormality of the lower motor neuron (HP:0002366)2.09804527
103Oligodactyly (HP:0012165)2.09134241
104Abnormal eating behavior (HP:0100738)2.08547369
105Increased muscle lipid content (HP:0009058)2.08377840
106Confusion (HP:0001289)2.08072456
107Excessive salivation (HP:0003781)2.07023478
108Pachygyria (HP:0001302)2.06880115
109Severe muscular hypotonia (HP:0006829)2.06224536
110Ankle clonus (HP:0011448)2.03721898
111Acute necrotizing encephalopathy (HP:0006965)2.03062689
112Absent speech (HP:0001344)2.02847349
113Muscle fiber atrophy (HP:0100295)2.02621890
114Foot dorsiflexor weakness (HP:0009027)2.02562292
115Hepatocellular necrosis (HP:0001404)2.02118003
116Ragged-red muscle fibers (HP:0003200)2.01248942
117EMG: neuropathic changes (HP:0003445)2.00843167
118Hyperammonemia (HP:0001987)2.00754633
119Respiratory distress (HP:0002098)1.99460252
120Occipital encephalocele (HP:0002085)1.97556766
121Renal dysplasia (HP:0000110)1.96103479
122Febrile seizures (HP:0002373)1.95477560
123Hyperinsulinemic hypoglycemia (HP:0000825)1.94908460
124Congestive heart failure (HP:0001635)1.94607996
125Abnormality of the 4th metacarpal (HP:0010012)1.94085987
126Lymphangioma (HP:0100764)1.94050426
127Generalized tonic-clonic seizures (HP:0002069)1.93152271
128Palpebral edema (HP:0100540)1.92887323
129Hypoventilation (HP:0002791)1.90023359
130Labial hypoplasia (HP:0000066)1.88559577
131Abnormality of the pulmonary veins (HP:0011718)1.88264850
132Acute encephalopathy (HP:0006846)1.88181784
133Lower limb amyotrophy (HP:0007210)1.87887918
134Turricephaly (HP:0000262)1.86573022
135Diaphragmatic weakness (HP:0009113)1.86559736
136Facial diplegia (HP:0001349)1.86172472
137Progressive cerebellar ataxia (HP:0002073)1.85002405
138Urinary bladder sphincter dysfunction (HP:0002839)1.84832602
139Neck muscle weakness (HP:0000467)1.83818631
140Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83061083
141Cerebral hypomyelination (HP:0006808)1.82799505
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81794349
143Large for gestational age (HP:0001520)1.80144440
144Decreased muscle mass (HP:0003199)1.77518492
145Cerebral hemorrhage (HP:0001342)1.76600651
146Muscular dystrophy (HP:0003560)1.76513273
147Medial flaring of the eyebrow (HP:0010747)1.74876586
148Visual hallucinations (HP:0002367)1.74089010
149Cholelithiasis (HP:0001081)1.73710937
150Narrow nasal bridge (HP:0000446)1.73551990
151Hyperglycinuria (HP:0003108)1.73520648
152Failure to thrive in infancy (HP:0001531)1.73087380
153Double outlet right ventricle (HP:0001719)1.72842962
154Congenital malformation of the right heart (HP:0011723)1.72842962
155Impaired vibration sensation in the lower limbs (HP:0002166)1.72496815
156Mildly elevated creatine phosphokinase (HP:0008180)1.71195528
157Narrow forehead (HP:0000341)1.70690811
158Pancreatic islet-cell hyperplasia (HP:0004510)1.70288582
159Congenital primary aphakia (HP:0007707)1.70244620
160Type 1 muscle fiber predominance (HP:0003803)1.69957369
161Buphthalmos (HP:0000557)1.67958504
162Increased intramyocellular lipid droplets (HP:0012240)1.67784818
163Abnormality of the tricuspid valve (HP:0001702)1.67274054
164Annular pancreas (HP:0001734)1.66907459
165Generalized muscle weakness (HP:0003324)1.66622956
166Nephrogenic diabetes insipidus (HP:0009806)1.66530466
167Pulmonary artery stenosis (HP:0004415)1.66410207
168Mitochondrial inheritance (HP:0001427)1.66217261
169Rapidly progressive (HP:0003678)1.64152539
170Thyroid-stimulating hormone excess (HP:0002925)1.64140484
171Lactic acidosis (HP:0003128)1.63949801
172Respiratory failure (HP:0002878)1.63852610
173Abnormality of the diencephalon (HP:0010662)1.63724473
174Abnormality of lateral ventricle (HP:0030047)1.63666460
175Broad-based gait (HP:0002136)1.63615607
176Abnormality of the renal medulla (HP:0100957)1.63213051
177Intellectual disability, moderate (HP:0002342)1.63091449
178Hypoplasia of the corpus callosum (HP:0002079)1.62353132
179Dialeptic seizures (HP:0011146)1.61555237
180Facial hemangioma (HP:0000329)1.60613279
181Hypoplastic female external genitalia (HP:0012815)1.60487939
182Meningocele (HP:0002435)1.59227386
183Limb dystonia (HP:0002451)1.59147620
184Proximal amyotrophy (HP:0007126)1.57993220
185Split foot (HP:0001839)1.57851988
186Conjunctival hamartoma (HP:0100780)1.57820347
187Nonprogressive disorder (HP:0003680)1.56833477
188Cortical visual impairment (HP:0100704)1.55666193
189Shawl scrotum (HP:0000049)1.55506938
190Shallow orbits (HP:0000586)1.54833216
191Vitreoretinal degeneration (HP:0000655)1.54792854
192Cystic liver disease (HP:0006706)1.54406523
193Vaginal atresia (HP:0000148)1.52226813
194Intellectual disability, severe (HP:0010864)1.52070679
195Absence seizures (HP:0002121)1.51621125
196Genital tract atresia (HP:0001827)1.51377298
197Hypoplastic ischia (HP:0003175)1.50648243
198Wide anterior fontanel (HP:0000260)1.50081910
199Partial duplication of the phalanx of hand (HP:0009999)1.48974690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.64637014
2MARK15.18313302
3CASK3.92607938
4LMTK23.67730003
5TIE13.63208856
6PHKG23.40926063
7PHKG13.40926063
8DMPK3.38286559
9MYLK3.37304773
10NTRK23.13225312
11PDK32.87047995
12PDK42.87047995
13PKN22.69639404
14OBSCN2.63851456
15TRIB32.62483584
16SIK22.55437144
17BCKDK2.38336155
18NTRK12.37064777
19MAP3K92.22155707
20NEK12.01721720
21KDR1.96861993
22DYRK21.94173393
23EPHB21.66049165
24PDK21.65817722
25TNIK1.65559521
26MAPK131.63668451
27TYRO31.62260219
28EPHA41.59967355
29MINK11.58199747
30CAMK1G1.55841412
31PAK31.54841763
32PIK3CA1.52938906
33SGK2231.45322056
34SGK4941.45322056
35PNCK1.43320736
36MUSK1.39834478
37MAP3K41.37828392
38PRKD11.37524540
39MAP3K71.35454514
40CAMK1D1.33724651
41UHMK11.33554302
42PTK2B1.28850503
43PINK11.27602206
44DYRK1A1.26441466
45RIPK11.23624084
46EPHB11.20411155
47CAMK2D1.19884653
48CDC42BPA1.18223694
49MAP2K31.16830642
50CDK51.13498991
51PRKCG1.11536040
52MAP2K71.11501911
53MAP2K41.05486792
54CAMKK11.05485086
55FGFR21.01997862
56KSR11.00533198
57STK240.99868052
58SGK20.99709823
59STK380.99688686
60INSRR0.99352752
61STK160.97929406
62PRKCZ0.97578806
63CAMK2B0.95472133
64WNK30.94419713
65GRK70.94216652
66MAPK120.91647031
67WNK40.91349955
68PRKAA20.90711818
69ROCK10.89736910
70DAPK30.88831093
71CDK190.88759953
72FER0.88705813
73MAP3K50.85727990
74RPS6KA20.85559249
75STK40.83322609
76DYRK1B0.82689529
77SIK10.81416568
78TAOK10.80711229
79FGFR40.80406707
80PRKD30.80094580
81TGFBR20.78740491
82RET0.78100905
83ICK0.77197011
84TGFBR10.75443857
85CAMKK20.75251828
86CAMK40.73581082
87PTK60.73067870
88PRKAA10.72133033
89ROCK20.72014869
90CDK11A0.71465945
91CDK150.71102911
92ILK0.70313822
93CDK180.68910887
94LIMK10.68125029
95CAMK2A0.66296902
96SGK30.66248489
97RPS6KC10.65837159
98RPS6KL10.65837159
99DAPK20.65367643
100ALK0.64341353
101WNK10.62924845
102MARK20.62122382
103CDK140.61420138
104PKN10.60828578
105ADRBK20.60442602
106CAMK10.60118021
107TRPM70.60114841
108FLT30.58782557
109PLK20.58108323
110CSNK1G20.57897042
111RPS6KA60.57244989
112PDGFRA0.56264237
113JAK10.56229519
114MAP3K60.56138347
115PDPK10.55292779
116STK110.54142872
117ERN10.52808940
118ERBB20.52329367
119MAPK100.51805397
120LRRK20.51647948
121PRKACB0.50731217
122TESK10.49602221
123NTRK30.49106017
124PRKACG0.49009637
125PRKCE0.47260623
126CDK90.45896354
127KSR20.45296636
128PDK10.44934810
129GRK10.44261738
130PRKCH0.43118374
131RPS6KA30.42810053
132CSNK1E0.42602625
133PRKG20.42442850
134RPS6KB10.42192739
135MAP3K10.41752478
136MAP3K110.41547048
137DDR20.41282365
138BCR0.40238534
139MAP3K30.39705486
140BLK0.39503731
141MET0.39040170
142PRKACA0.38408233
143MAPKAPK30.35171898
144STK38L0.34084466
145JAK20.33476914
146PAK60.32889372
147PRKCQ0.31538971
148MTOR0.28911585
149ZAK0.28771578
150FES0.28143744
151SGK10.28132328
152MAP2K60.27608309
153TYK20.25828126
154CLK10.25470869
155MAP3K130.25232676
156CAMK2G0.24768646
157PDGFRB0.24109845
158PTK20.22979507
159PRKD20.22872579

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.87774407
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.40616627
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.08592292
4Nicotine addiction_Homo sapiens_hsa050333.62115812
5Cardiac muscle contraction_Homo sapiens_hsa042603.61125816
6Dilated cardiomyopathy_Homo sapiens_hsa054143.33768533
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.13628289
8Propanoate metabolism_Homo sapiens_hsa006402.84993417
9Fatty acid degradation_Homo sapiens_hsa000712.79579577
10Cocaine addiction_Homo sapiens_hsa050302.56530111
11GABAergic synapse_Homo sapiens_hsa047272.42059625
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27795330
13Glutamatergic synapse_Homo sapiens_hsa047242.24073529
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15389631
15Carbon metabolism_Homo sapiens_hsa012002.15314659
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14200562
17Arginine biosynthesis_Homo sapiens_hsa002202.08463038
18Parkinsons disease_Homo sapiens_hsa050122.00372518
19Autoimmune thyroid disease_Homo sapiens_hsa053202.00316134
20Dopaminergic synapse_Homo sapiens_hsa047281.95780800
21Axon guidance_Homo sapiens_hsa043601.92235888
22Synaptic vesicle cycle_Homo sapiens_hsa047211.89598665
23Fatty acid metabolism_Homo sapiens_hsa012121.86211941
24Oxidative phosphorylation_Homo sapiens_hsa001901.84766913
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79489325
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.70252324
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69774923
28Viral myocarditis_Homo sapiens_hsa054161.66009508
29Amphetamine addiction_Homo sapiens_hsa050311.65498886
30Pyruvate metabolism_Homo sapiens_hsa006201.58251682
31Alzheimers disease_Homo sapiens_hsa050101.55913321
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46057777
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44048332
34Phototransduction_Homo sapiens_hsa047441.42701351
35Butanoate metabolism_Homo sapiens_hsa006501.39420380
36Basal cell carcinoma_Homo sapiens_hsa052171.35092265
37PPAR signaling pathway_Homo sapiens_hsa033201.34338230
38Hedgehog signaling pathway_Homo sapiens_hsa043401.31584213
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28253450
40Tryptophan metabolism_Homo sapiens_hsa003801.28058168
41Notch signaling pathway_Homo sapiens_hsa043301.27206350
42Melanogenesis_Homo sapiens_hsa049161.26628726
43Hippo signaling pathway_Homo sapiens_hsa043901.24329260
44Thyroid hormone synthesis_Homo sapiens_hsa049181.24027177
45Sulfur relay system_Homo sapiens_hsa041221.23233434
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20416836
47Gap junction_Homo sapiens_hsa045401.14550114
48Biosynthesis of amino acids_Homo sapiens_hsa012301.13605951
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12014714
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09943494
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.09682642
52Insulin resistance_Homo sapiens_hsa049311.08335772
53Glucagon signaling pathway_Homo sapiens_hsa049221.05538547
54Huntingtons disease_Homo sapiens_hsa050161.04100695
55Lysine degradation_Homo sapiens_hsa003101.00064340
56Bile secretion_Homo sapiens_hsa049760.98450293
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97909358
58Tyrosine metabolism_Homo sapiens_hsa003500.97183538
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96406597
60Starch and sucrose metabolism_Homo sapiens_hsa005000.93761416
61Gastric acid secretion_Homo sapiens_hsa049710.91624542
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91519001
63Serotonergic synapse_Homo sapiens_hsa047260.91440060
64Nitrogen metabolism_Homo sapiens_hsa009100.89603315
65Wnt signaling pathway_Homo sapiens_hsa043100.84338039
66beta-Alanine metabolism_Homo sapiens_hsa004100.83870777
67Calcium signaling pathway_Homo sapiens_hsa040200.81909109
68Long-term depression_Homo sapiens_hsa047300.81036633
69Glioma_Homo sapiens_hsa052140.80249230
70Fatty acid elongation_Homo sapiens_hsa000620.78399778
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75842749
72HIF-1 signaling pathway_Homo sapiens_hsa040660.74955119
73Insulin signaling pathway_Homo sapiens_hsa049100.73866161
74Oxytocin signaling pathway_Homo sapiens_hsa049210.72748331
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71852833
76cAMP signaling pathway_Homo sapiens_hsa040240.71667980
77Phenylalanine metabolism_Homo sapiens_hsa003600.71160156
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70591968
79Arginine and proline metabolism_Homo sapiens_hsa003300.68619659
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67448780
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.66930002
82Dorso-ventral axis formation_Homo sapiens_hsa043200.66507527
83Focal adhesion_Homo sapiens_hsa045100.66398631
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65900253
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65891427
86Ras signaling pathway_Homo sapiens_hsa040140.64859772
87Type II diabetes mellitus_Homo sapiens_hsa049300.64416585
88MAPK signaling pathway_Homo sapiens_hsa040100.63359152
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.62239657
90ErbB signaling pathway_Homo sapiens_hsa040120.61753316
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60948902
92Renin secretion_Homo sapiens_hsa049240.59275791
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59009478
94Steroid biosynthesis_Homo sapiens_hsa001000.58794905
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58700469
96Adherens junction_Homo sapiens_hsa045200.58648668
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.58456560
98Ether lipid metabolism_Homo sapiens_hsa005650.57456447
99Circadian entrainment_Homo sapiens_hsa047130.56704940
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.55396618
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55345404
102Peroxisome_Homo sapiens_hsa041460.54742549
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.54376708
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54005554
105AMPK signaling pathway_Homo sapiens_hsa041520.53661436
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53067233
107Circadian rhythm_Homo sapiens_hsa047100.52932978
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52601712
109Vibrio cholerae infection_Homo sapiens_hsa051100.49179010
110VEGF signaling pathway_Homo sapiens_hsa043700.44599547
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44196070
112Fat digestion and absorption_Homo sapiens_hsa049750.43967047
113Insulin secretion_Homo sapiens_hsa049110.43804381
114Melanoma_Homo sapiens_hsa052180.43803837
115Ribosome_Homo sapiens_hsa030100.43719458
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43350947
117mTOR signaling pathway_Homo sapiens_hsa041500.42531649
118Oocyte meiosis_Homo sapiens_hsa041140.41693089
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.39143275
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38657868
121Amoebiasis_Homo sapiens_hsa051460.37522487
122Tight junction_Homo sapiens_hsa045300.36478308
123ECM-receptor interaction_Homo sapiens_hsa045120.36184640
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35663669
125Fatty acid biosynthesis_Homo sapiens_hsa000610.35033173
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.34604205
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32737242
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31579327
129Morphine addiction_Homo sapiens_hsa050320.31397630
130Estrogen signaling pathway_Homo sapiens_hsa049150.31271608
131Caffeine metabolism_Homo sapiens_hsa002320.30222136
132Salivary secretion_Homo sapiens_hsa049700.28383475
133Taste transduction_Homo sapiens_hsa047420.26959982
134Renal cell carcinoma_Homo sapiens_hsa052110.26909740
135Galactose metabolism_Homo sapiens_hsa000520.25445788
136GnRH signaling pathway_Homo sapiens_hsa049120.24486719
137Mineral absorption_Homo sapiens_hsa049780.24414359
138Long-term potentiation_Homo sapiens_hsa047200.24256330
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23195587
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22132319
141Rap1 signaling pathway_Homo sapiens_hsa040150.21399552
142Pancreatic secretion_Homo sapiens_hsa049720.18466501
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17180437
144Fructose and mannose metabolism_Homo sapiens_hsa000510.16407186
145Cholinergic synapse_Homo sapiens_hsa047250.16356434
146Glycerolipid metabolism_Homo sapiens_hsa005610.14748232
147Olfactory transduction_Homo sapiens_hsa047400.14419372
148Toxoplasmosis_Homo sapiens_hsa051450.14246699

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