SLC26A11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the solute linked carrier 26 family of anion exchangers. Members of this family of proteins are essential for numerous cellular functions including homeostasis and intracellular electrolyte balance. The encoded protein is a sodium independent sulfate transporter that is sensitive to the anion exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.26396385
2transcription from mitochondrial promoter (GO:0006390)7.75153060
3embryonic process involved in female pregnancy (GO:0060136)7.66958798
4positive regulation of protein homooligomerization (GO:0032464)7.47283502
5replication fork processing (GO:0031297)6.99055340
6regulation of integrin activation (GO:0033623)6.78743196
7oxidative demethylation (GO:0070989)6.31593122
8regulation of protein homooligomerization (GO:0032462)6.17857959
9establishment of apical/basal cell polarity (GO:0035089)6.03346685
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.47576097
11cellular response to ATP (GO:0071318)5.34563244
12DNA deamination (GO:0045006)5.31315059
13positive regulation of developmental pigmentation (GO:0048087)5.19592358
14poly(A)+ mRNA export from nucleus (GO:0016973)5.12783773
15establishment or maintenance of monopolar cell polarity (GO:0061339)5.09194794
16establishment of monopolar cell polarity (GO:0061162)5.09194794
17mitochondrial DNA metabolic process (GO:0032042)4.95789026
18DNA strand renaturation (GO:0000733)4.90263093
19glycosphingolipid catabolic process (GO:0046479)4.86723850
20negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.85499443
21negative regulation of interleukin-12 production (GO:0032695)4.85371224
22embryonic placenta development (GO:0001892)4.82400014
23oligosaccharide catabolic process (GO:0009313)4.69062931
24negative regulation of JAK-STAT cascade (GO:0046426)4.64959357
25amino sugar catabolic process (GO:0046348)4.60884155
26glutamine family amino acid biosynthetic process (GO:0009084)4.56739192
27somatic hypermutation of immunoglobulin genes (GO:0016446)4.56081910
28somatic diversification of immune receptors via somatic mutation (GO:0002566)4.56081910
29negative regulation of protein oligomerization (GO:0032460)4.50764901
30mitotic G1 DNA damage checkpoint (GO:0031571)4.45248323
31glycolipid catabolic process (GO:0019377)4.32069397
32mitotic G1/S transition checkpoint (GO:0044819)4.28641921
33positive regulation of protein oligomerization (GO:0032461)4.28624390
34viral mRNA export from host cell nucleus (GO:0046784)4.26352485
35regulation of mononuclear cell migration (GO:0071675)4.24160263
36negative regulation of fatty acid biosynthetic process (GO:0045717)4.22066031
37DNA integration (GO:0015074)4.20704896
38G1 DNA damage checkpoint (GO:0044783)4.14298588
39ceramide catabolic process (GO:0046514)4.09715195
40labyrinthine layer development (GO:0060711)4.07271961
41regulation of protein oligomerization (GO:0032459)4.06168323
42negative regulation of cell cycle arrest (GO:0071157)4.01057498
43positive regulation by host of viral transcription (GO:0043923)3.98305623
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.97614405
45mRNA cleavage (GO:0006379)3.94974885
46positive regulation of receptor recycling (GO:0001921)3.93900854
47cellular response to zinc ion (GO:0071294)3.93866726
48negative regulation of Ras GTPase activity (GO:0034261)3.92846767
49protein localization to endosome (GO:0036010)3.90662784
50response to peptidoglycan (GO:0032494)3.85001964
51apoptotic process involved in morphogenesis (GO:0060561)3.84488212
52face development (GO:0060324)3.72145738
53convergent extension (GO:0060026)3.70705558
54negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.70389744
55membrane tubulation (GO:0097320)3.69614932
56regulation of vitamin D biosynthetic process (GO:0060556)3.69538561
57glial cell migration (GO:0008347)3.68416466
58sulfur amino acid catabolic process (GO:0000098)3.67259543
59regulation of translational fidelity (GO:0006450)3.62932841
60negative regulation of stress fiber assembly (GO:0051497)3.58824489
61positive regulation of heat generation (GO:0031652)3.57133761
62protein targeting to vacuole (GO:0006623)3.56852943
63protein targeting to lysosome (GO:0006622)3.56852943
64establishment of protein localization to vacuole (GO:0072666)3.56852943
65regulation of mitochondrial depolarization (GO:0051900)3.56297011
66regulation of response to reactive oxygen species (GO:1901031)3.56186152
67very-low-density lipoprotein particle assembly (GO:0034379)3.56001067
68membrane invagination (GO:0010324)3.54468343
69regulation of cholesterol storage (GO:0010885)3.53947110
70heme transport (GO:0015886)3.53321320
71negative regulation of tumor necrosis factor production (GO:0032720)3.52331157
72positive regulation of chemokine biosynthetic process (GO:0045080)3.52245721
73membrane lipid catabolic process (GO:0046466)3.51202410
74regulation of chronic inflammatory response (GO:0002676)3.50940736
75regulation of hydrogen peroxide-induced cell death (GO:1903205)3.50923152
76negative regulation of nitric oxide biosynthetic process (GO:0045019)3.44468901
77negative regulation of cell killing (GO:0031342)3.41892789
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.41892789
79sphingolipid catabolic process (GO:0030149)3.41582854
80negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.40961893
81anatomical structure regression (GO:0060033)3.40116640
82lipopolysaccharide-mediated signaling pathway (GO:0031663)3.39017086
83alkaloid metabolic process (GO:0009820)3.38445017
84negative regulation of response to reactive oxygen species (GO:1901032)3.35621323
85regulation of RNA export from nucleus (GO:0046831)3.33516744
86monocyte chemotaxis (GO:0002548)3.32570402
87cellular response to thyroid hormone stimulus (GO:0097067)3.30437416
88embryonic camera-type eye development (GO:0031076)3.28481479
89positive regulation of monocyte chemotaxis (GO:0090026)3.27597287
90base-excision repair (GO:0006284)3.26444499
91double-strand break repair via nonhomologous end joining (GO:0006303)3.22684495
92non-recombinational repair (GO:0000726)3.22684495
93N-acetylneuraminate metabolic process (GO:0006054)3.22503194
94negative regulation of viral release from host cell (GO:1902187)3.21015446
95axon ensheathment in central nervous system (GO:0032291)3.20160891
96central nervous system myelination (GO:0022010)3.20160891
97regulation of chemokine biosynthetic process (GO:0045073)3.19872994
98DNA demethylation (GO:0080111)3.18252662
99sphingomyelin metabolic process (GO:0006684)3.16785969
100positive regulation of gamma-delta T cell activation (GO:0046645)3.15950313
101hypotonic response (GO:0006971)3.13907868
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.12703495
103mannose metabolic process (GO:0006013)3.11747464
104eosinophil chemotaxis (GO:0048245)3.11673474
105negative regulation of heart rate (GO:0010459)3.11466673
106base-excision repair, AP site formation (GO:0006285)3.11363264
107macrophage activation involved in immune response (GO:0002281)3.10680439
108establishment of mitochondrion localization (GO:0051654)3.09581104
109regulation of podosome assembly (GO:0071801)3.09468461
110myeloid dendritic cell differentiation (GO:0043011)3.09053946
111mitotic cell cycle arrest (GO:0071850)3.06099886
112regulation of early endosome to late endosome transport (GO:2000641)3.05570373
113negative regulation of cytokine production involved in immune response (GO:0002719)3.05521056
114nuclear envelope reassembly (GO:0031468)3.04337163
115mitotic nuclear envelope reassembly (GO:0007084)3.04337163
116spliceosomal tri-snRNP complex assembly (GO:0000244)3.04107766
117regulation of glomerular filtration (GO:0003093)3.03050954
118regulation of cytokine secretion involved in immune response (GO:0002739)3.01727064
119neutrophil activation involved in immune response (GO:0002283)3.01474272
120negative regulation of interleukin-1 beta production (GO:0032691)3.01284602
121lysosome organization (GO:0007040)3.00120290
122lytic vacuole organization (GO:0080171)3.00120290
123pentose metabolic process (GO:0019321)2.98000823
124granulocyte activation (GO:0036230)2.96745981
125negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.96218430
126regulation of cell size (GO:0008361)2.95147299
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.93526878
128asymmetric protein localization (GO:0008105)2.93108051
129negative regulation of appetite (GO:0032099)2.92801286
130negative regulation of response to food (GO:0032096)2.92801286
131activation of Rac GTPase activity (GO:0032863)2.91870766
132ganglioside metabolic process (GO:0001573)2.90015238
133signal complex assembly (GO:0007172)2.89795022
134NIK/NF-kappaB signaling (GO:0038061)2.89174084
135cellular response to toxic substance (GO:0097237)2.89161592
136regulation of fever generation (GO:0031620)2.88826860
137trophectodermal cell differentiation (GO:0001829)2.88511197
138phagosome maturation (GO:0090382)2.87743171
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86780175
140positive regulation of DNA repair (GO:0045739)2.86773258
141regulation of heat generation (GO:0031650)2.86449730
142positive regulation of antigen processing and presentation (GO:0002579)2.86282781
143pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84047751
144negative regulation of mRNA processing (GO:0050686)2.83181602
145positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80782951
146positive regulation of cholesterol efflux (GO:0010875)2.77875060
147regulation of T cell tolerance induction (GO:0002664)2.76059558
148immunoglobulin mediated immune response (GO:0016064)2.72957532
149eosinophil migration (GO:0072677)2.72797802
150positive regulation of mast cell activation (GO:0033005)2.72248108
151negative regulation of interleukin-1 production (GO:0032692)2.67467578
152regulation of vitamin metabolic process (GO:0030656)2.64429422
153adhesion of symbiont to host cell (GO:0044650)2.63735553
154virion attachment to host cell (GO:0019062)2.63735553
155regulation of membrane protein ectodomain proteolysis (GO:0051043)2.63114726
156regulation of interleukin-12 production (GO:0032655)2.62575986
157negative regulation of production of molecular mediator of immune response (GO:0002701)2.61755457
158regulation of interleukin-2 biosynthetic process (GO:0045076)2.59821771
159positive regulation of NF-kappaB import into nucleus (GO:0042346)2.59197818
160positive regulation of leukocyte degranulation (GO:0043302)2.58856091
161positive regulation of mast cell degranulation (GO:0043306)2.58320924
162positive regulation of mast cell activation involved in immune response (GO:0033008)2.58320924
163positive regulation of calcium-mediated signaling (GO:0050850)2.58146445
164regulation of mast cell degranulation (GO:0043304)2.56991064
165amyloid precursor protein catabolic process (GO:0042987)2.56863738
166keratan sulfate catabolic process (GO:0042340)2.54611608
167negative regulation of lipid storage (GO:0010888)2.54559190
168regulation of macrophage chemotaxis (GO:0010758)2.54171672
169myeloid dendritic cell activation (GO:0001773)2.54046490
170T-helper 1 type immune response (GO:0042088)2.51311164
171regulation of T-helper 1 cell differentiation (GO:0045625)2.51074541
172response to muramyl dipeptide (GO:0032495)2.50544448
173regulation of monocyte chemotaxis (GO:0090025)2.50413619
174interferon-gamma-mediated signaling pathway (GO:0060333)2.50188754
175branching involved in labyrinthine layer morphogenesis (GO:0060670)2.49865035
176positive regulation of lymphocyte apoptotic process (GO:0070230)2.49218631
177regulation of antigen processing and presentation (GO:0002577)2.48819705
178regulation of mast cell activation (GO:0033003)2.47877323
179regulation of interferon-alpha production (GO:0032647)2.47597521
180cellular response to lipopolysaccharide (GO:0071222)2.47059192
181regulation of interferon-beta biosynthetic process (GO:0045357)2.46908794
182regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.46484559
183detection of molecule of bacterial origin (GO:0032490)2.45165651
184regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.44851058
185regulation of natural killer cell mediated immunity (GO:0002715)2.44851058
186response to acidic pH (GO:0010447)2.44377193
187type I interferon signaling pathway (GO:0060337)2.44340045
188cellular response to type I interferon (GO:0071357)2.44340045
189cellular response to molecule of bacterial origin (GO:0071219)2.43520622
190germinal center formation (GO:0002467)2.43466984
191vitamin D metabolic process (GO:0042359)2.42860216
192fat-soluble vitamin biosynthetic process (GO:0042362)2.42800618
193response to type I interferon (GO:0034340)2.41820269
194regulation of nitric oxide biosynthetic process (GO:0045428)2.41121092
195pH reduction (GO:0045851)2.39538255
196adhesion of symbiont to host (GO:0044406)2.39460965
197proline biosynthetic process (GO:0006561)10.5903447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.33911432
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.31726522
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.58083574
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.58083574
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.58083574
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.55750524
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36616972
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.35664395
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.18132067
10VDR_21846776_ChIP-Seq_THP-1_Human3.05553873
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.99932551
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.92549609
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86149008
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76054100
15* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.74384138
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.63002284
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39239569
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38401344
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.35341424
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34531631
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32679705
22POU5F1_16518401_ChIP-PET_MESCs_Mouse2.29374876
23* LXR_22292898_ChIP-Seq_THP-1_Human2.25010718
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22632428
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19819826
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.10903976
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10479926
28KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.09243863
29TCF3_18692474_ChIP-Seq_MESCs_Mouse2.09129653
30* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07379521
31* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03147630
32PU.1_20513432_ChIP-Seq_Bcells_Mouse2.02597298
33PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.89593803
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87903243
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87383373
36VDR_24787735_ChIP-Seq_THP-1_Human1.85420251
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81881874
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76268080
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74216533
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71317514
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.69362528
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67821203
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67758705
44RACK7_27058665_Chip-Seq_MCF-7_Human1.67481371
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66211447
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64535419
47SPI1_23127762_ChIP-Seq_K562_Human1.63713093
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.59806174
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56386515
50* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56250476
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56177558
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56053101
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54780303
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54626561
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53093875
56KDM2B_26808549_Chip-Seq_DND41_Human1.52031616
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.51543296
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49947065
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.49530081
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46666125
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46310975
62RXR_22158963_ChIP-Seq_LIVER_Mouse1.46169102
63STAT1_20625510_ChIP-Seq_HELA_Human1.45847664
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42936656
65NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39243340
66* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37712275
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.37347995
68ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37170758
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36157514
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.35544739
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.35522396
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35428921
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34662663
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34041571
75* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.33718826
76RUNX_20019798_ChIP-Seq_JUKART_Human1.33406831
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32971939
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32662577
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30776127
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29111261
81VDR_24763502_ChIP-Seq_THP-1_Human1.27576908
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26989666
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26600819
84POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26384986
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.25749534
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25653747
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25134406
88SPI1_23547873_ChIP-Seq_NB4_Human1.25119965
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24917810
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24649266
91ETS1_21867929_ChIP-Seq_TH2_Mouse1.23802748
92MYC_22102868_ChIP-Seq_BL_Human1.23471272
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22489126
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22220622
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21882219
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.21820493
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21356593
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20581293
99* RARB_24833708_ChIP-Seq_LIVER_Mouse1.20328919
100* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19424253
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19398649
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18808941
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17838117
104PU_27001747_Chip-Seq_BMDM_Mouse1.15517761
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15073261
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.14370052
107* BCOR_27268052_Chip-Seq_Bcells_Human1.14326438
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14224283
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13883736
110SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13363310
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.11717648
112* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11651107
113* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11420262
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10389001
115CDX2_20551321_ChIP-Seq_CACO-2_Human1.09934880
116* P68_20966046_ChIP-Seq_HELA_Human1.09233550
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09232959
118PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09168853
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08939412
120MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07435703
121* SPI1_26923725_Chip-Seq_HPCs_Mouse1.06686452
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06648365
123MAF_26560356_Chip-Seq_TH1_Human1.05436830
124TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04657236
125* E2F1_20622854_ChIP-Seq_HELA_Human1.04135801
126LXR_22158963_ChIP-Seq_LIVER_Mouse1.03205575
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02595200
128* UTX_26944678_Chip-Seq_JUKART_Human1.02188951
129NANOG_18692474_ChIP-Seq_MEFs_Mouse1.02180049
130TRIM28_21343339_ChIP-Seq_HEK293_Human1.02126391
131ZNF263_19887448_ChIP-Seq_K562_Human1.00964037
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00204338
133SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99874424
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99252970
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98726506
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98519393
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98364987
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98160058
139MYC_18555785_ChIP-Seq_MESCs_Mouse0.97479377
140MAF_26560356_Chip-Seq_TH2_Human0.97464022
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.97263662
142FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97121134
143SA1_27219007_Chip-Seq_ERYTHROID_Human0.97020622
144KDM2B_26808549_Chip-Seq_JURKAT_Human0.96973233
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96459163
146TCF7_22412390_ChIP-Seq_EML_Mouse0.96096095
147SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96045673
148* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95851692
149KDM2B_26808549_Chip-Seq_K562_Human0.95548522
150CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94762663
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94644817
152* SMC4_20622854_ChIP-Seq_HELA_Human0.94491540
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94101020
154* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93882150
155SA1_27219007_Chip-Seq_Bcells_Human0.93794825
156* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93712875
157CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93235627
158SCL_19346495_ChIP-Seq_HPC-7_Human0.93209930
159BCL6_27268052_Chip-Seq_Bcells_Human0.92272545
160OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92191645
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91907049
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.90850661
163STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89551512
164SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86335419
165PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84821744
166NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84138054
167DROSHA_22980978_ChIP-Seq_HELA_Human0.83438808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.66983899
2MP0005171_absent_coat_pigmentation5.10412344
3MP0009278_abnormal_bone_marrow4.95955607
4MP0005058_abnormal_lysosome_morphology3.97373337
5MP0003303_peritoneal_inflammation3.85842662
6MP0010030_abnormal_orbit_morphology3.19314703
7MP0003172_abnormal_lysosome_physiology3.18736004
8MP0002009_preneoplasia3.09297497
9MP0005671_abnormal_response_to3.08316956
10MP0002148_abnormal_hypersensitivity_rea2.95592113
11MP0003436_decreased_susceptibility_to2.94835032
12MP0003724_increased_susceptibility_to2.83374605
13MP0005174_abnormal_tail_pigmentation2.83158691
14MP0000604_amyloidosis2.79308965
15MP0004233_abnormal_muscle_weight2.65727339
16MP0009785_altered_susceptibility_to2.50055558
17MP0002419_abnormal_innate_immunity2.49753016
18MP0002254_reproductive_system_inflammat2.40461005
19MP0005000_abnormal_immune_tolerance2.29120517
20MP0001835_abnormal_antigen_presentation2.28128934
21MP0002139_abnormal_hepatobiliary_system2.28076244
22MP0004510_myositis2.27457550
23MP0005387_immune_system_phenotype2.25634356
24MP0001790_abnormal_immune_system2.25634356
25MP0003453_abnormal_keratinocyte_physiol2.16442441
26MP0005075_abnormal_melanosome_morpholog2.14069328
27MP0005025_abnormal_response_to2.12888533
28MP0004133_heterotaxia2.11351016
29MP0003283_abnormal_digestive_organ2.10320744
30MP0001545_abnormal_hematopoietic_system2.10104889
31MP0005397_hematopoietic_system_phenotyp2.10104889
32MP0005167_abnormal_blood-brain_barrier2.06388258
33MP0000015_abnormal_ear_pigmentation2.05832765
34MP0008995_early_reproductive_senescence2.05561371
35MP0000343_altered_response_to2.01787184
36MP0009764_decreased_sensitivity_to1.95241176
37MP0003300_gastrointestinal_ulcer1.90641546
38MP0002452_abnormal_antigen_presenting1.88107933
39MP0001533_abnormal_skeleton_physiology1.88085885
40MP0002723_abnormal_immune_serum1.86944932
41MP0006082_CNS_inflammation1.84266156
42MP0003890_abnormal_embryonic-extraembry1.82810507
43MP0003329_amyloid_beta_deposits1.79483509
44MP0002998_abnormal_bone_remodeling1.77711856
45MP0003191_abnormal_cellular_cholesterol1.77448608
46MP0002249_abnormal_larynx_morphology1.76757071
47MP0002282_abnormal_trachea_morphology1.76717831
48MP0005310_abnormal_salivary_gland1.76396564
49MP0000579_abnormal_nail_morphology1.66576949
50MP0001800_abnormal_humoral_immune1.62688569
51MP0005451_abnormal_body_composition1.60571895
52MP0000462_abnormal_digestive_system1.60186121
53MP0000371_diluted_coat_color1.58343701
54MP0002420_abnormal_adaptive_immunity1.56577360
55MP0001819_abnormal_immune_cell1.55776400
56MP0009840_abnormal_foam_cell1.55718426
57MP0001845_abnormal_inflammatory_respons1.53224641
58MP0000685_abnormal_immune_system1.52159880
59MP0004947_skin_inflammation1.51877265
60MP0003656_abnormal_erythrocyte_physiolo1.48898642
61MP0006072_abnormal_retinal_apoptosis1.47382157
62MP0008469_abnormal_protein_level1.47240747
63MP0000639_abnormal_adrenal_gland1.45146860
64MP0001293_anophthalmia1.39356832
65MP0001853_heart_inflammation1.38573395
66MP0000470_abnormal_stomach_morphology1.37068418
67MP0001340_abnormal_eyelid_morphology1.36074382
68MP0000920_abnormal_myelination1.34818855
69MP0003195_calcinosis1.32212626
70MP0005365_abnormal_bile_salt1.30753167
71MP0003448_altered_tumor_morphology1.28341634
72MP0006054_spinal_hemorrhage1.26023593
73MP0010155_abnormal_intestine_physiology1.25192964
74MP0002086_abnormal_extraembryonic_tissu1.20289481
75MP0002405_respiratory_system_inflammati1.19154702
76MP0003786_premature_aging1.17197465
77MP0003634_abnormal_glial_cell1.17190692
78MP0003119_abnormal_digestive_system1.16117554
79MP0002060_abnormal_skin_morphology1.15615057
80MP0005085_abnormal_gallbladder_physiolo1.14842156
81MP0004142_abnormal_muscle_tone1.11428386
82MP0002269_muscular_atrophy1.08932402
83MP0005166_decreased_susceptibility_to1.07159606
84MP0005076_abnormal_cell_differentiation1.06300212
85MP0002084_abnormal_developmental_patter1.06251568
86MP0003690_abnormal_glial_cell1.05741069
87MP0001324_abnormal_eye_pigmentation1.03987462
88MP0002090_abnormal_vision1.03295543
89MP0003828_pulmonary_edema1.02783590
90MP0000716_abnormal_immune_system0.99956262
91MP0004197_abnormal_fetal_growth/weight/0.99653271
92MP0003879_abnormal_hair_cell0.99634596
93MP0000858_altered_metastatic_potential0.98993407
94MP0005257_abnormal_intraocular_pressure0.96877388
95MP0002796_impaired_skin_barrier0.96262946
96MP0003567_abnormal_fetal_cardiomyocyte0.95430657
97MP0002075_abnormal_coat/hair_pigmentati0.94933788
98MP0001697_abnormal_embryo_size0.94448014
99MP0002111_abnormal_tail_morphology0.94389289
100MP0003045_fibrosis0.94245140
101MP0000467_abnormal_esophagus_morphology0.93589422
102MP0010352_gastrointestinal_tract_polyps0.93169880
103MP0003950_abnormal_plasma_membrane0.93074977
104MP0002933_joint_inflammation0.92955941
105MP0002332_abnormal_exercise_endurance0.91356430
106MP0002932_abnormal_joint_morphology0.90452019
107MP0003183_abnormal_peptide_metabolism0.90265003
108MP0003806_abnormal_nucleotide_metabolis0.89714229
109MP0008004_abnormal_stomach_pH0.89379572
110MP0002085_abnormal_embryonic_tissue0.89345379
111MP0005464_abnormal_platelet_physiology0.86572282
112MP0005390_skeleton_phenotype0.86401725
113MP0002653_abnormal_ependyma_morphology0.85559749
114MP0000689_abnormal_spleen_morphology0.85504340
115MP0000762_abnormal_tongue_morphology0.85239697
116MP0003136_yellow_coat_color0.84330248
117MP0000490_abnormal_crypts_of0.82416630
118MP0002837_dystrophic_cardiac_calcinosis0.82291973
119MP0001501_abnormal_sleep_pattern0.81311790
120MP0004134_abnormal_chest_morphology0.80679430
121MP0010094_abnormal_chromosome_stability0.80568692
122MP0009333_abnormal_splenocyte_physiolog0.79512942
123MP0005508_abnormal_skeleton_morphology0.76801453
124MP0005647_abnormal_sex_gland0.76499767
125MP0002166_altered_tumor_susceptibility0.75341075
126MP0005023_abnormal_wound_healing0.74979506
127MP0003075_altered_response_to0.74916308
128MP0005266_abnormal_metabolism0.74863711
129MP0008932_abnormal_embryonic_tissue0.74551963
130MP0004185_abnormal_adipocyte_glucose0.72848602
131MP0003795_abnormal_bone_structure0.72624607
132MP0009115_abnormal_fat_cell0.72496018
133MP0001186_pigmentation_phenotype0.72408166
134MP0003633_abnormal_nervous_system0.71960858
135MP0003566_abnormal_cell_adhesion0.71718174
136MP0005377_hearing/vestibular/ear_phenot0.71168888
137MP0003878_abnormal_ear_physiology0.71168888
138MP0003279_aneurysm0.70817167
139MP0004019_abnormal_vitamin_homeostasis0.69990205
140MP0008874_decreased_physiological_sensi0.69747892
141MP0001542_abnormal_bone_strength0.69422184
142MP0001663_abnormal_digestive_system0.68143727
143MP0002114_abnormal_axial_skeleton0.67155258
144MP0008877_abnormal_DNA_methylation0.65803290
145MP0004858_abnormal_nervous_system0.65778341
146MP0005164_abnormal_response_to0.65214621
147MP0002429_abnormal_blood_cell0.64910331
148MP0002229_neurodegeneration0.64365567
149MP0003632_abnormal_nervous_system0.63431222
150MP0009763_increased_sensitivity_to0.62990340
151MP0001672_abnormal_embryogenesis/_devel0.62546732
152MP0005380_embryogenesis_phenotype0.62546732
153MP0003631_nervous_system_phenotype0.62368205
154MP0001873_stomach_inflammation0.61635516
155MP0003755_abnormal_palate_morphology0.61387656
156MP0000432_abnormal_head_morphology0.61369346
157MP0005595_abnormal_vascular_smooth0.60516641
158MP0002064_seizures0.60429715
159MP0003935_abnormal_craniofacial_develop0.60365820
160MP0002277_abnormal_respiratory_mucosa0.60043295
161MP0002108_abnormal_muscle_morphology0.59947800
162MP0002693_abnormal_pancreas_physiology0.58420618
163MP0002398_abnormal_bone_marrow0.58028839
164MP0002019_abnormal_tumor_incidence0.57787451
165MP0008260_abnormal_autophagy0.57402377
166MP0004742_abnormal_vestibular_system0.57292082
167MP0009765_abnormal_xenobiotic_induced0.57246868
168MP0010386_abnormal_urinary_bladder0.56493399
169MP0000367_abnormal_coat/_hair0.56348469
170MP0010630_abnormal_cardiac_muscle0.56240441
171MP0003137_abnormal_impulse_conducting0.56209811
172MP0003638_abnormal_response/metabolism_0.56068577
173MP0005253_abnormal_eye_physiology0.53762652
174MP0001784_abnormal_fluid_regulation0.53624819
175MP0005391_vision/eye_phenotype0.53464161

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)9.02641322
2Abnormality of glycosphingolipid metabolism (HP:0004343)9.02641322
3Abnormality of glycolipid metabolism (HP:0010969)9.02641322
4Vacuolated lymphocytes (HP:0001922)6.47613882
5Increased cerebral lipofuscin (HP:0011813)6.17331309
6Pustule (HP:0200039)5.62654880
7Increased neuronal autofluorescent lipopigment (HP:0002074)5.19206773
8Concave nail (HP:0001598)5.17154286
9Rib fusion (HP:0000902)5.15549892
10Turricephaly (HP:0000262)5.15545838
11Rectal fistula (HP:0100590)5.10121541
12Rectovaginal fistula (HP:0000143)5.10121541
13Intestinal fistula (HP:0100819)4.82234174
14Ulnar bowing (HP:0003031)4.79235921
15Loss of speech (HP:0002371)4.73414743
16Abnormality of macrophages (HP:0004311)4.70219663
17Vaginal fistula (HP:0004320)4.64982114
18Alopecia of scalp (HP:0002293)4.63465654
19Anteriorly placed anus (HP:0001545)4.56410788
20Facial hemangioma (HP:0000329)4.40479942
21Increased IgM level (HP:0003496)4.39827515
22Coronal craniosynostosis (HP:0004440)4.35781479
23Dysostosis multiplex (HP:0000943)4.30316796
24Disinhibition (HP:0000734)4.30183539
25Annular pancreas (HP:0001734)4.22495352
26Mutism (HP:0002300)4.22020319
27Premature skin wrinkling (HP:0100678)4.16210022
28Hypochromic microcytic anemia (HP:0004840)4.06091141
29Poikiloderma (HP:0001029)4.01278960
30Alacrima (HP:0000522)3.97104155
31Urinary glycosaminoglycan excretion (HP:0003541)3.89858975
32Mucopolysacchariduria (HP:0008155)3.89858975
33Systemic lupus erythematosus (HP:0002725)3.84867263
34Clumsiness (HP:0002312)3.71465115
35Abnormality of polysaccharide metabolism (HP:0011012)3.62041361
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.62041361
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.62041361
38Nuclear cataract (HP:0100018)3.57407905
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.46319995
40Orchitis (HP:0100796)3.44733582
41Recurrent bacterial skin infections (HP:0005406)3.44613764
42Retrobulbar optic neuritis (HP:0100654)3.43553680
43Optic neuritis (HP:0100653)3.43553680
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.42927731
45Male infertility (HP:0003251)3.39896425
46Abnormal hemoglobin (HP:0011902)3.38810425
47Autoimmune thrombocytopenia (HP:0001973)3.35695290
48Eczematoid dermatitis (HP:0000976)3.31548860
49Myositis (HP:0100614)3.28442328
50Short humerus (HP:0005792)3.24719117
51Broad alveolar ridges (HP:0000187)3.23561456
52Albinism (HP:0001022)3.21136348
53Recurrent abscess formation (HP:0002722)3.17532953
54Stomatitis (HP:0010280)3.17161990
55Vertebral hypoplasia (HP:0008417)3.11565948
56Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.11565948
57Tongue fasciculations (HP:0001308)3.11421268
58Abnormality of male internal genitalia (HP:0000022)3.08964538
59Diaphragmatic weakness (HP:0009113)3.06370997
60Apathy (HP:0000741)3.03244542
61Aplasia/hypoplasia of the humerus (HP:0006507)3.01814811
62Diminished motivation (HP:0000745)3.01437672
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.98910580
64Large for gestational age (HP:0001520)2.98375653
65Intestinal atresia (HP:0011100)2.94078217
66Decreased lacrimation (HP:0000633)2.93408980
67Orthostatic hypotension (HP:0001278)2.92594416
68Dysautonomia (HP:0002459)2.91935193
69Neuronal loss in central nervous system (HP:0002529)2.85371890
70Pancreatic islet-cell hyperplasia (HP:0004510)2.84582972
71Aplasia of the musculature (HP:0100854)2.81888407
72Hypokinesia (HP:0002375)2.81368010
73Muscle fibrillation (HP:0010546)2.81130422
74Retinal atrophy (HP:0001105)2.79759919
75J-shaped sella turcica (HP:0002680)2.74713398
76Joint stiffness (HP:0001387)2.73414933
77Mediastinal lymphadenopathy (HP:0100721)2.73343272
78Cerebral inclusion bodies (HP:0100314)2.72788741
79Short chin (HP:0000331)2.69636390
80Cerebral aneurysm (HP:0004944)2.67765928
81Congenital hip dislocation (HP:0001374)2.67710447
82Choanal stenosis (HP:0000452)2.66329252
83Absent radius (HP:0003974)2.61508165
84Prolonged neonatal jaundice (HP:0006579)2.60240852
85Hematochezia (HP:0002573)2.59703510
86Inappropriate behavior (HP:0000719)2.57382214
87Bowed forearm bones (HP:0003956)2.56001391
88Bowing of the arm (HP:0006488)2.56001391
89Recurrent gram-negative bacterial infections (HP:0005420)2.54979386
90Hypotrichosis (HP:0001006)2.52955619
91Supranuclear gaze palsy (HP:0000605)2.49209694
92Bifid uvula (HP:0000193)2.48573460
93Hamartoma (HP:0010566)2.46737443
94Absent forearm bone (HP:0003953)2.46422436
95Aplasia involving forearm bones (HP:0009822)2.46422436
96T lymphocytopenia (HP:0005403)2.43598731
97Polycythemia (HP:0001901)2.43122610
98Squamous cell carcinoma (HP:0002860)2.43108187
99Metaphyseal irregularity (HP:0003025)2.39887407
100Increased serum ferritin (HP:0003281)2.38875749
101Purpura (HP:0000979)2.34447135
102Dementia (HP:0000726)2.33960947
103Hypotelorism (HP:0000601)2.32754037
104Abnormality of the aortic arch (HP:0012303)2.32051812
105Pulmonary infiltrates (HP:0002113)2.30990927
106Asymmetric septal hypertrophy (HP:0001670)2.30354832
107Global brain atrophy (HP:0002283)2.28378861
108Narrow nasal bridge (HP:0000446)2.27393789
109Diminished movement (HP:0002374)2.27232355
110Agnosia (HP:0010524)2.23321716
111Xanthomatosis (HP:0000991)2.22987009
112Upper motor neuron abnormality (HP:0002127)2.22809470
113Peripheral demyelination (HP:0011096)2.21636842
114Glomerulonephritis (HP:0000099)2.21347505
115Split hand (HP:0001171)2.21194958
116Thickened helices (HP:0000391)2.20630139
117Colitis (HP:0002583)2.17561714
118Progressive neurologic deterioration (HP:0002344)2.16870198
119IgA deficiency (HP:0002720)2.16790928
120Obstructive lung disease (HP:0006536)2.12930047
121Chronic obstructive pulmonary disease (HP:0006510)2.12930047
122Hypochromic anemia (HP:0001931)2.12773837
123Growth hormone excess (HP:0000845)2.09302408
124Abnormality of T cell number (HP:0011839)2.09011331
125Vertebral fusion (HP:0002948)2.08548076
126Abnormality of the vasculature of the conjunctiva (HP:0008054)2.08332282
127Basal cell carcinoma (HP:0002671)2.08110603
128Myocardial infarction (HP:0001658)2.07894500
129Cardiomegaly (HP:0001640)2.07332247
130Mesangial abnormality (HP:0001966)2.05773093
131Hepatosplenomegaly (HP:0001433)2.05477579
132Keratoconjunctivitis sicca (HP:0001097)2.05150670
133Agitation (HP:0000713)2.03442814
134Increased CSF protein (HP:0002922)2.00348493
135Elevated erythrocyte sedimentation rate (HP:0003565)1.99876439
136Abnormality of placental membranes (HP:0011409)1.98800547
137Amniotic constriction ring (HP:0009775)1.98800547
138Keratoconjunctivitis (HP:0001096)1.97961527
139Capillary hemangiomas (HP:0005306)1.96870073
140Hemoptysis (HP:0002105)1.96526163
141Cheilitis (HP:0100825)1.96261018
142Pathologic fracture (HP:0002756)1.95944602
143Recurrent skin infections (HP:0001581)1.95410745
144Amelogenesis imperfecta (HP:0000705)1.95288113
145Protuberant abdomen (HP:0001538)1.93904344
146Premature graying of hair (HP:0002216)1.92702010
147Bulbar palsy (HP:0001283)1.92206815
148Neurofibrillary tangles (HP:0002185)1.91891553
149Personality changes (HP:0000751)1.91447995
150Polyneuropathy (HP:0001271)1.90500036
151Hypoplasia of the ulna (HP:0003022)1.89517581
152Gastrointestinal atresia (HP:0002589)1.89455207
153Thoracic kyphosis (HP:0002942)1.89253626
154Axonal loss (HP:0003447)1.83969893
155Amyloidosis (HP:0011034)1.82558618
156Abnormality of the periventricular white matter (HP:0002518)1.80585880
157Generalized amyotrophy (HP:0003700)1.80461752
158Abnormality of iron homeostasis (HP:0011031)1.79992072
159Memory impairment (HP:0002354)1.77434157
160Depressed nasal tip (HP:0000437)1.76901349
161Lower limb hyperreflexia (HP:0002395)1.76872665
162Basal ganglia calcification (HP:0002135)1.76569420
163Increased number of teeth (HP:0011069)1.76400673
164Ectopic anus (HP:0004397)1.75505767
165Volvulus (HP:0002580)1.75304431
166Absent thumb (HP:0009777)1.74882399
167Acne (HP:0001061)1.73439637
168Recurrent fungal infections (HP:0002841)1.71010799
169Ovoid vertebral bodies (HP:0003300)1.69763278
170Zonular cataract (HP:0010920)1.68756074
171Coarse hair (HP:0002208)1.68172976
172Interstitial pulmonary disease (HP:0006530)1.68148481
173Redundant skin (HP:0001582)1.67536792
174Polyphagia (HP:0002591)1.62188885
175Deformed sella turcica (HP:0002681)1.62019177
176Urinary incontinence (HP:0000020)1.61968875
177Bone pain (HP:0002653)1.60749683
178Thin bony cortex (HP:0002753)1.60129744
179Macroglossia (HP:0000158)1.59946294
180Abnormality of transition element cation homeostasis (HP:0011030)1.58890682
181Parakeratosis (HP:0001036)1.58710996
182Pulmonary embolism (HP:0002204)1.58700286
183Poor head control (HP:0002421)1.57932618

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.18341167
2MAPK155.15004436
3DDR24.94146797
4MAP3K64.23803437
5IRAK33.98020106
6FGR3.52231734
7GRK73.39718691
8MAP3K113.15473334
9TYRO33.05501739
10PINK12.98625701
11MATK2.82078121
12TXK2.75194885
13CSK2.48298368
14PRKD22.46862229
15UHMK12.45254352
16ADRBK22.39409573
17TBK12.22972492
18TRPM72.21015142
19MAP3K142.14942434
20BMX2.13053832
21YES12.11128277
22ACVR1B2.01923251
23PIM22.00862506
24DYRK1B1.92150522
25DAPK11.92014546
26NME21.90028835
27TYK21.86551808
28TGFBR21.84367042
29PDGFRA1.63139999
30IRAK41.62756547
31ERN11.52944846
32RIPK41.52591209
33TAOK11.51215330
34MAP3K31.48443372
35RIPK11.48254451
36CAMKK21.45378960
37CAMK1D1.43744287
38IKBKE1.40977793
39MAP2K61.39840443
40ZAP701.39787250
41CDK61.36604035
42CDK71.34371961
43SIK31.34138940
44DAPK21.29396721
45PIM11.28408542
46MAP2K31.27812785
47EPHB11.26603975
48GSK3A1.24139280
49PHKG11.18860135
50PHKG21.18860135
51RPS6KL11.11878985
52RPS6KC11.11878985
53CHUK1.11764231
54AKT31.08660406
55RPS6KA61.02317114
56MOS1.01091075
57ABL20.99267098
58JAK30.98143100
59FES0.97826241
60PRPF4B0.96747160
61MAPK110.96144616
62CDC42BPA0.95828008
63RPS6KA20.94086149
64CAMKK10.92835086
65STK390.88307431
66PRKD30.88038773
67MAP3K130.84784114
68BLK0.84460531
69MAP4K10.84444252
70MARK30.82551562
71JAK10.81488732
72MAP3K10.80676556
73ITK0.80342364
74LIMK10.78116618
75HIPK20.77883374
76MAP3K100.75710810
77TAOK30.75369255
78IRAK10.73696160
79IRAK20.72828787
80TRIB30.70965928
81SYK0.70769660
82CSNK1G10.70696132
83MTOR0.68899084
84TESK10.68617420
85HCK0.67569735
86CHEK20.66408054
87LATS20.66236909
88EPHA30.65746657
89LYN0.65135942
90CAMK2B0.62711083
91PDGFRB0.62252974
92CAMK1G0.61182136
93MAPK120.60153095
94PAK60.59794924
95EGFR0.59521514
96TESK20.57573465
97PDK10.55343877
98PDPK10.55020040
99LCK0.54617423
100PRKAA10.52209074
101NTRK20.52060839
102PDK20.51849396
103CAMK2G0.50951190
104FGFR40.50904107
105PRKAA20.50648220
106KIT0.50595234
107RAF10.50284980
108IKBKB0.48615562
109MAP3K50.47920998
110PRKD10.47854198
111RPS6KA10.47303713
112KDR0.45813914
113OXSR10.44059280
114BTK0.43619694
115CAMK2D0.43551878
116MARK20.41538448
117INSR0.41265567
118MAPK10.41020315
119MAPK30.40439787
120MET0.40359428
121TNK20.40248423
122PTK20.39181733
123MAPK100.36744800
124PRKCQ0.36075616
125PRKCH0.36011699
126MAPK40.36007191
127PAK20.35495343
128DYRK30.35298997
129MAP3K90.34379785
130MAPK70.33361308
131STK100.32960034
132FYN0.31482386
133TAOK20.31237414
134BMPR20.30433013
135CDK120.29273445
136ABL10.28959311
137MUSK0.28287690
138CSNK1G20.28148719
139CSNK1A1L0.27373543
140CAMK2A0.27221834
141PKN10.27144700
142CSNK2A10.26492624
143CSF1R0.26289587
144CDK20.25731086
145DYRK20.24703821
146CSNK1G30.24690112
147SGK10.24482582
148SIK10.24314337
149MELK0.23895737
150PLK10.23877488
151MAPKAPK20.23280694
152PRKCD0.21263372
153STK30.20403614
154MAPK140.19984644
155CLK10.18236727
156JAK20.17861624
157PRKCZ0.17315915
158CSNK2A20.15668560
159SIK20.15112237
160GRK60.13042660
161RPS6KA30.12978243
162MAP2K20.11184499
163ATR0.10710019
164FLT30.10473502

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.39396963
2Other glycan degradation_Homo sapiens_hsa005114.35511072
3Base excision repair_Homo sapiens_hsa034103.87216796
4Mismatch repair_Homo sapiens_hsa034303.64102114
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.13027472
6Steroid biosynthesis_Homo sapiens_hsa001003.09443049
7Rheumatoid arthritis_Homo sapiens_hsa053232.81725810
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.63131004
9Arginine and proline metabolism_Homo sapiens_hsa003302.61262334
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.49404681
11Osteoclast differentiation_Homo sapiens_hsa043802.44219277
12Notch signaling pathway_Homo sapiens_hsa043302.30850264
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.27566913
14Fatty acid metabolism_Homo sapiens_hsa012122.26852145
15Fatty acid elongation_Homo sapiens_hsa000622.18603615
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.08270586
17Collecting duct acid secretion_Homo sapiens_hsa049662.05111015
18Allograft rejection_Homo sapiens_hsa053301.94223714
19Graft-versus-host disease_Homo sapiens_hsa053321.93418508
20DNA replication_Homo sapiens_hsa030301.91758454
21Hedgehog signaling pathway_Homo sapiens_hsa043401.88464661
22Tuberculosis_Homo sapiens_hsa051521.86957600
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.85883641
24Leishmaniasis_Homo sapiens_hsa051401.85463506
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.83658811
26Malaria_Homo sapiens_hsa051441.78188909
27Folate biosynthesis_Homo sapiens_hsa007901.78042315
28Circadian rhythm_Homo sapiens_hsa047101.75555186
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75366836
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74850312
31mTOR signaling pathway_Homo sapiens_hsa041501.73784392
32TNF signaling pathway_Homo sapiens_hsa046681.69875826
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68600865
34Pertussis_Homo sapiens_hsa051331.67836737
35Hippo signaling pathway_Homo sapiens_hsa043901.65832578
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60082287
37Lysine degradation_Homo sapiens_hsa003101.57992863
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.57504176
39Autoimmune thyroid disease_Homo sapiens_hsa053201.57243766
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57160129
41Antigen processing and presentation_Homo sapiens_hsa046121.54391848
42Sulfur relay system_Homo sapiens_hsa041221.54086359
43Salmonella infection_Homo sapiens_hsa051321.53177993
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.52338047
45Asthma_Homo sapiens_hsa053101.51214438
46Primary immunodeficiency_Homo sapiens_hsa053401.47332768
47Lysosome_Homo sapiens_hsa041421.46835121
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46413192
49Intestinal immune network for IgA production_Homo sapiens_hsa046721.40538936
50Type I diabetes mellitus_Homo sapiens_hsa049401.38021894
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37342827
52Shigellosis_Homo sapiens_hsa051311.36959674
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34195911
54TGF-beta signaling pathway_Homo sapiens_hsa043501.33092394
55Adherens junction_Homo sapiens_hsa045201.32282447
56Biosynthesis of amino acids_Homo sapiens_hsa012301.28860795
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27822388
58Nucleotide excision repair_Homo sapiens_hsa034201.19603111
59Vibrio cholerae infection_Homo sapiens_hsa051101.18584995
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18078990
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.17961382
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16776919
63Hematopoietic cell lineage_Homo sapiens_hsa046401.16695982
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15620448
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14722067
66Sphingolipid metabolism_Homo sapiens_hsa006001.13548647
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10713535
68Toxoplasmosis_Homo sapiens_hsa051451.10695781
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08905552
70T cell receptor signaling pathway_Homo sapiens_hsa046601.07406872
71Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02844916
72mRNA surveillance pathway_Homo sapiens_hsa030151.01751281
73Chemokine signaling pathway_Homo sapiens_hsa040621.01351277
74Basal cell carcinoma_Homo sapiens_hsa052171.00742523
75Arginine biosynthesis_Homo sapiens_hsa002200.99334068
76Synaptic vesicle cycle_Homo sapiens_hsa047210.99022392
77Wnt signaling pathway_Homo sapiens_hsa043100.97386382
78VEGF signaling pathway_Homo sapiens_hsa043700.97297269
79p53 signaling pathway_Homo sapiens_hsa041150.96433813
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96382156
81Bladder cancer_Homo sapiens_hsa052190.93578158
82Dorso-ventral axis formation_Homo sapiens_hsa043200.92803416
83African trypanosomiasis_Homo sapiens_hsa051430.89089141
84Influenza A_Homo sapiens_hsa051640.87369374
85B cell receptor signaling pathway_Homo sapiens_hsa046620.85323646
86Homologous recombination_Homo sapiens_hsa034400.82568602
87Glutathione metabolism_Homo sapiens_hsa004800.79970332
88Choline metabolism in cancer_Homo sapiens_hsa052310.79039991
89Hepatitis C_Homo sapiens_hsa051600.78256218
90Staphylococcus aureus infection_Homo sapiens_hsa051500.77897719
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75935094
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.72926294
93Fructose and mannose metabolism_Homo sapiens_hsa000510.71203596
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70700218
95Spliceosome_Homo sapiens_hsa030400.70472054
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69716736
97Endocytosis_Homo sapiens_hsa041440.68642002
98Fanconi anemia pathway_Homo sapiens_hsa034600.68437466
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65059069
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.64686497
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64212690
102Tight junction_Homo sapiens_hsa045300.62465610
103Apoptosis_Homo sapiens_hsa042100.59811276
104PPAR signaling pathway_Homo sapiens_hsa033200.58940919
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58795487
106Colorectal cancer_Homo sapiens_hsa052100.58477901
107Mineral absorption_Homo sapiens_hsa049780.58102308
108Acute myeloid leukemia_Homo sapiens_hsa052210.56610340
109Herpes simplex infection_Homo sapiens_hsa051680.54954888
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54640085
111MicroRNAs in cancer_Homo sapiens_hsa052060.54562603
112Histidine metabolism_Homo sapiens_hsa003400.54370683
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53322414
114ABC transporters_Homo sapiens_hsa020100.53316871
115Hepatitis B_Homo sapiens_hsa051610.53163887
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52859393
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52335039
118Ether lipid metabolism_Homo sapiens_hsa005650.52315510
119Prolactin signaling pathway_Homo sapiens_hsa049170.52309173
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.51534216
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.51339814
122Amoebiasis_Homo sapiens_hsa051460.50170998
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49043338
124Type II diabetes mellitus_Homo sapiens_hsa049300.48921884
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48356956
126RNA transport_Homo sapiens_hsa030130.46702606
127Viral myocarditis_Homo sapiens_hsa054160.46361625
128ErbB signaling pathway_Homo sapiens_hsa040120.46189353
129Chronic myeloid leukemia_Homo sapiens_hsa052200.44861718
130AMPK signaling pathway_Homo sapiens_hsa041520.44532414
131Vitamin B6 metabolism_Homo sapiens_hsa007500.41169485
132Nitrogen metabolism_Homo sapiens_hsa009100.41168666
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.40805614
134Galactose metabolism_Homo sapiens_hsa000520.40524951
135Glycerolipid metabolism_Homo sapiens_hsa005610.39876267
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38840768
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38835400
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.38410039
139GnRH signaling pathway_Homo sapiens_hsa049120.37227543
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36380836
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.35621216
142Proteoglycans in cancer_Homo sapiens_hsa052050.33912389
143Caffeine metabolism_Homo sapiens_hsa002320.33749586
144Ovarian steroidogenesis_Homo sapiens_hsa049130.33334633
145MAPK signaling pathway_Homo sapiens_hsa040100.30921915
146Sulfur metabolism_Homo sapiens_hsa009200.29914833
147Legionellosis_Homo sapiens_hsa051340.29086958
148Gap junction_Homo sapiens_hsa045400.26348427
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25891944
150Phagosome_Homo sapiens_hsa041450.25748554
151Small cell lung cancer_Homo sapiens_hsa052220.25416306
152Focal adhesion_Homo sapiens_hsa045100.25080276
153Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.23703005
154Insulin resistance_Homo sapiens_hsa049310.23157058
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23097467
156Prion diseases_Homo sapiens_hsa050200.22730391
157Epstein-Barr virus infection_Homo sapiens_hsa051690.22084429
158Linoleic acid metabolism_Homo sapiens_hsa005910.20906852
159Complement and coagulation cascades_Homo sapiens_hsa046100.20902664
160Leukocyte transendothelial migration_Homo sapiens_hsa046700.20517745
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20096704
162Pancreatic cancer_Homo sapiens_hsa052120.19799518
163HIF-1 signaling pathway_Homo sapiens_hsa040660.18957754
164Maturity onset diabetes of the young_Homo sapiens_hsa049500.17560512
165Prostate cancer_Homo sapiens_hsa052150.14949192
166Insulin signaling pathway_Homo sapiens_hsa049100.14838850
167Measles_Homo sapiens_hsa051620.13384847

Most similar genes based on co-expression Upload to Enrichr

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