SLC26A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)7.05301748
2cellular glucuronidation (GO:0052695)6.80108922
3maintenance of gastrointestinal epithelium (GO:0030277)6.56333295
4polyketide metabolic process (GO:0030638)6.54374549
5doxorubicin metabolic process (GO:0044598)6.54374549
6daunorubicin metabolic process (GO:0044597)6.54374549
7glucuronate metabolic process (GO:0019585)6.51575357
8uronic acid metabolic process (GO:0006063)6.51575357
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.26072874
10UDP-N-acetylglucosamine metabolic process (GO:0006047)5.83092919
11positive regulation of respiratory burst (GO:0060267)5.76488492
12angiotensin maturation (GO:0002003)5.69292885
13renal system process involved in regulation of blood volume (GO:0001977)5.63632473
14transcytosis (GO:0045056)5.56392921
15positive regulation of fatty acid beta-oxidation (GO:0032000)5.20274186
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.17438814
17endocrine process (GO:0050886)5.17438814
18regulation of systemic arterial blood pressure by hormone (GO:0001990)5.17438814
19purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.14728074
203-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.14728074
21receptor guanylyl cyclase signaling pathway (GO:0007168)5.11744433
22O-glycan processing (GO:0016266)4.98921836
23response to pheromone (GO:0019236)4.87953281
24positive regulation of guanylate cyclase activity (GO:0031284)4.84237959
25intestinal epithelial cell development (GO:0060576)4.82759643
26calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.82081614
27epoxygenase P450 pathway (GO:0019373)4.67913177
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.63817158
29negative regulation of keratinocyte proliferation (GO:0010839)4.62560223
30epithelial structure maintenance (GO:0010669)4.61360153
31* sulfate transmembrane transport (GO:1902358)4.60927885
32ethanol oxidation (GO:0006069)4.53948413
33glomerular filtration (GO:0003094)4.50383157
34regulation of systemic arterial blood pressure (GO:0003073)4.47542442
35NADH metabolic process (GO:0006734)4.46516514
36regulation of cGMP biosynthetic process (GO:0030826)4.25747448
37fat-soluble vitamin biosynthetic process (GO:0042362)4.20838891
38cGMP-mediated signaling (GO:0019934)4.18290611
39positive regulation of pseudopodium assembly (GO:0031274)4.12556101
40renal filtration (GO:0097205)4.11220643
41intestinal absorption (GO:0050892)4.08923987
42renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)4.00765470
43positive regulation of fatty acid oxidation (GO:0046321)4.00224987
44regulation of cholesterol homeostasis (GO:2000188)3.92946895
45aminoglycoside antibiotic metabolic process (GO:0030647)3.91683271
46diol metabolic process (GO:0034311)3.89038139
47regulation of cellular extravasation (GO:0002691)3.88722201
48flavonoid metabolic process (GO:0009812)3.88684701
49* sulfate transport (GO:0008272)3.87456434
50drug transmembrane transport (GO:0006855)3.86225119
51fucose catabolic process (GO:0019317)3.84696742
52L-fucose metabolic process (GO:0042354)3.84696742
53L-fucose catabolic process (GO:0042355)3.84696742
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.84482045
55sphingoid metabolic process (GO:0046519)3.83803027
56nucleoside diphosphate biosynthetic process (GO:0009133)3.82257356
57negative regulation of myotube differentiation (GO:0010832)3.75769406
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.73523212
59regulation of respiratory burst (GO:0060263)3.73424177
60regulation of pseudopodium assembly (GO:0031272)3.69126440
61drug metabolic process (GO:0017144)3.62360378
62positive regulation of interleukin-1 secretion (GO:0050716)3.61871767
63sodium ion homeostasis (GO:0055078)3.61720509
64one-carbon metabolic process (GO:0006730)3.58217328
65labyrinthine layer development (GO:0060711)3.57865615
66cellular anion homeostasis (GO:0030002)3.56501013
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.56367481
68ethanol metabolic process (GO:0006067)3.55334047
69sulfation (GO:0051923)3.50762994
70lipoprotein transport (GO:0042953)3.50144845
71drug transport (GO:0015893)3.49455952
72regulation of cGMP metabolic process (GO:0030823)3.49346070
73nucleotide transmembrane transport (GO:1901679)3.48691855
74sulfur amino acid catabolic process (GO:0000098)3.42127207
75positive regulation of lipid catabolic process (GO:0050996)3.40043674
76auditory receptor cell differentiation (GO:0042491)3.37618929
77interferon-gamma production (GO:0032609)3.36945197
78diacylglycerol metabolic process (GO:0046339)3.36456604
79cellular response to pH (GO:0071467)3.35539144
80presynaptic membrane assembly (GO:0097105)3.33744883
81protein O-linked glycosylation (GO:0006493)3.32495466
82hormone catabolic process (GO:0042447)3.32174780
83positive regulation of prostaglandin secretion (GO:0032308)3.30558741
84auditory receptor cell stereocilium organization (GO:0060088)3.28701477
85regulation of fatty acid beta-oxidation (GO:0031998)3.28344354
86urea cycle (GO:0000050)3.27859413
87dendritic cell chemotaxis (GO:0002407)3.24892784
88antibacterial humoral response (GO:0019731)3.22617887
89kidney morphogenesis (GO:0060993)3.20745714
90fucose metabolic process (GO:0006004)3.20523481
91exogenous drug catabolic process (GO:0042738)3.20449915
92desmosome organization (GO:0002934)3.20140926
93protein heterotetramerization (GO:0051290)3.20094914
94regulation of vitamin metabolic process (GO:0030656)3.19779964
95glycerol metabolic process (GO:0006071)3.19233314
96drug catabolic process (GO:0042737)3.19209299
97receptor recycling (GO:0001881)3.18621309
98sphingomyelin metabolic process (GO:0006684)3.14409734
99positive regulation of glycoprotein biosynthetic process (GO:0010560)3.13851417
100lung secretory cell differentiation (GO:0061140)3.12990982
101regulation of interleukin-1 secretion (GO:0050704)3.12928826
102nucleotide-sugar metabolic process (GO:0009225)3.12617452
103digestive system process (GO:0022600)3.11641282
104vitamin transmembrane transport (GO:0035461)3.11222925
105phenylpropanoid metabolic process (GO:0009698)3.11129588
106antimicrobial humoral response (GO:0019730)3.10605156
107glycosphingolipid catabolic process (GO:0046479)3.10046244
108* sulfur compound transport (GO:0072348)3.09937144
109regulation of bile acid biosynthetic process (GO:0070857)3.09555802
110glycosylceramide metabolic process (GO:0006677)3.09516224
111positive regulation of interleukin-1 beta secretion (GO:0050718)3.08793690
112hepatocyte apoptotic process (GO:0097284)3.08787523
113phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.05837359
114urea metabolic process (GO:0019627)3.05389527
115regulation of pigment cell differentiation (GO:0050932)3.04650728
116intermediate filament organization (GO:0045109)3.04130496
117negative regulation of leukocyte chemotaxis (GO:0002689)3.02902872
118nucleotide-sugar biosynthetic process (GO:0009226)3.02657412
119purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.02336967
120ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.02336967
121nucleoside bisphosphate biosynthetic process (GO:0033866)3.02336967
122cGMP biosynthetic process (GO:0006182)3.01159310
123sialylation (GO:0097503)3.01142271
124glycolipid catabolic process (GO:0019377)2.99932107
125digestion (GO:0007586)2.99928960
126vitamin A metabolic process (GO:0006776)2.98370079
127striated muscle atrophy (GO:0014891)2.98301962
128dendritic cell migration (GO:0036336)2.96898843
129regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.96729509
130positive regulation of glycoprotein metabolic process (GO:1903020)2.94681776
131regulation of chemokine secretion (GO:0090196)2.94193579
132glucocorticoid biosynthetic process (GO:0006704)2.93934790
133regulation of protein glycosylation (GO:0060049)2.93642581
134eosinophil chemotaxis (GO:0048245)2.91768552
135regulation of histone H3-K27 methylation (GO:0061085)2.89364061
136regulation of actin nucleation (GO:0051125)2.88042691
137detection of molecule of bacterial origin (GO:0032490)2.87202280
138regulation of keratinocyte proliferation (GO:0010837)2.86314334
139actin filament depolymerization (GO:0030042)2.84949372
140bile acid and bile salt transport (GO:0015721)2.83266697
141muscle atrophy (GO:0014889)2.83049196
142positive regulation of epidermal cell differentiation (GO:0045606)2.82389231
143negative regulation of protein autophosphorylation (GO:0031953)2.79477275
144regulation of interleukin-1 beta secretion (GO:0050706)2.79354673
145sphingosine metabolic process (GO:0006670)2.78253689
146phosphate ion homeostasis (GO:0055062)2.78046338
147trivalent inorganic anion homeostasis (GO:0072506)2.78046338
148oligosaccharide catabolic process (GO:0009313)2.77967341
149oligosaccharide biosynthetic process (GO:0009312)2.77345254
150thrombin receptor signaling pathway (GO:0070493)2.76726027
151positive regulation of icosanoid secretion (GO:0032305)2.73339176
152postsynaptic membrane organization (GO:0001941)2.73129789
153mature B cell differentiation (GO:0002335)2.72156863
154phosphatidylcholine biosynthetic process (GO:0006656)2.71218390
155presynaptic membrane organization (GO:0097090)2.70582760
156embryonic camera-type eye morphogenesis (GO:0048596)2.69982589
157neural tube formation (GO:0001841)2.69172805
158regulation of metalloenzyme activity (GO:0048552)2.67733560
159positive regulation of systemic arterial blood pressure (GO:0003084)2.66494706
160regulation of interleukin-8 secretion (GO:2000482)2.66190821
161keratan sulfate biosynthetic process (GO:0018146)2.62507453
162glycosphingolipid biosynthetic process (GO:0006688)2.60513926
163regulation of prostaglandin secretion (GO:0032306)2.58778902
164neurotransmitter biosynthetic process (GO:0042136)2.56181448
165developmental pigmentation (GO:0048066)2.54746437
166lateral ventricle development (GO:0021670)2.51134925
167positive regulation of uterine smooth muscle contraction (GO:0070474)2.51085586
168positive regulation of actin filament depolymerization (GO:0030836)2.49873139
169positive regulation of interleukin-1 production (GO:0032732)2.49335725
170positive regulation of interleukin-8 secretion (GO:2000484)2.48929630
171positive regulation of cellular amide metabolic process (GO:0034250)2.47957344
172detection of external biotic stimulus (GO:0098581)2.47230043
173skeletal muscle adaptation (GO:0043501)2.45915327
174amino sugar metabolic process (GO:0006040)2.45267381
175positive regulation of epidermis development (GO:0045684)2.44837731
176* bicarbonate transport (GO:0015701)2.44595234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human3.94480298
2CDX2_19796622_ChIP-Seq_MESCs_Mouse3.28316697
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.23291527
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.90508952
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75741726
6VDR_22108803_ChIP-Seq_LS180_Human2.64593344
7FOXO3_23340844_ChIP-Seq_DLD1_Human2.64014146
8GBX2_23144817_ChIP-Seq_PC3_Human2.59775506
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.50480667
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.47897880
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.36946671
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31131166
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.29133746
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.23598097
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.22483059
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19362807
17* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14139940
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.08411388
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.08056004
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.07570820
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05360577
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04058685
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02249326
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01731840
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98444188
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.97362298
27SOX2_20726797_ChIP-Seq_SW620_Human1.97088568
28EZH2_22144423_ChIP-Seq_EOC_Human1.92554195
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80492121
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80345034
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.78048020
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77143741
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.76683803
34* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.71211524
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68591817
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.68236933
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66343874
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.66170695
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.65731672
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64576595
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.62751960
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56323615
43GATA4_25053715_ChIP-Seq_YYC3_Human1.56251570
44* CDX2_22108803_ChIP-Seq_LS180_Human1.56037522
45SUZ12_18555785_Chip-Seq_ESCs_Mouse1.55236337
46* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52313256
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52094628
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51930049
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.51808285
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51730789
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51498934
52EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50121187
53P53_22387025_ChIP-Seq_ESCs_Mouse1.49609488
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.48976024
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48579827
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.48142228
57KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47720131
58STAT3_18555785_Chip-Seq_ESCs_Mouse1.47712727
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47256517
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.45558554
61E2F1_18555785_Chip-Seq_ESCs_Mouse1.44561482
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43910138
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43441044
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41918729
65ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40839826
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.40325957
67RACK7_27058665_Chip-Seq_MCF-7_Human1.39812730
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.39061198
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37981800
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37573851
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.36538105
72AR_21909140_ChIP-Seq_LNCAP_Human1.34963766
73P300_18555785_Chip-Seq_ESCs_Mouse1.34289050
74OCT4_18555785_Chip-Seq_ESCs_Mouse1.31463395
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.31441594
76ZNF263_19887448_ChIP-Seq_K562_Human1.31299498
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31170177
78GATA6_25053715_ChIP-Seq_YYC3_Human1.29986649
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28903543
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28578269
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28018593
82NMYC_18555785_Chip-Seq_ESCs_Mouse1.26942257
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.26701705
84CLOCK_20551151_ChIP-Seq_293T_Human1.25605432
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25358431
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24863120
87RXR_22108803_ChIP-Seq_LS180_Human1.24698269
88BCAT_22108803_ChIP-Seq_LS180_Human1.23709192
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22962098
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.22897072
91FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22073342
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22029518
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.21682170
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.21399471
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.19913619
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18979767
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18186640
98VDR_24787735_ChIP-Seq_THP-1_Human1.18089409
99PU1_27457419_Chip-Seq_LIVER_Mouse1.17939872
100KLF4_18555785_Chip-Seq_ESCs_Mouse1.17283398
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16738721
102DROSHA_22980978_ChIP-Seq_HELA_Human1.16671204
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16574954
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16570828
105* CEBPB_22108803_ChIP-Seq_LS180_Human1.16400134
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15825046
107* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15097373
108* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14577438
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13962575
110SMAD3_21741376_ChIP-Seq_HESCs_Human1.13435436
111KLF5_25053715_ChIP-Seq_YYC3_Human1.12145047
112RNF2_27304074_Chip-Seq_NSC_Mouse1.11566548
113GATA2_19941826_ChIP-Seq_K562_Human1.11099299
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10498759
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10498759
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08874304
117JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.08853462
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08724398
119CTCF_18555785_Chip-Seq_ESCs_Mouse1.08651378
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.08642850
121GATA1_19941826_ChIP-Seq_K562_Human1.08173121
122Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07416784
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.06922931
124LXR_22292898_ChIP-Seq_THP-1_Human1.06907917
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.06470537
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06170034
127GATA3_24758297_ChIP-Seq_MCF-7_Human1.05225873
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04279022
129SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03719125
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03464149
131SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03133863
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02940133
133PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01959092
134RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01904008
135P300_19829295_ChIP-Seq_ESCs_Human1.01694351
136* CRX_20693478_ChIP-Seq_RETINA_Mouse1.01565328
137* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01184479
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01053955
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00785654
140IRF1_19129219_ChIP-ChIP_H3396_Human0.99393043
141SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99216146
142P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98863633
143* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98615389
144SMAD1_18555785_Chip-Seq_ESCs_Mouse0.98248774
145CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97633065
146PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97482739
147KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93729230
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88318710
149NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88034388
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86622102
151PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86169842
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85996425
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85773520
154STAT1_20625510_ChIP-Seq_HELA_Human0.85744874
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85460215
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.81745039
157SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81182810
158NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79149135
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78662625
160SA1_27219007_Chip-Seq_Bcells_Human0.77789659
161NANOG_20526341_ChIP-Seq_ESCs_Human0.76800650
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74442219
163SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73868460
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73366782
165TCF3_18692474_ChIP-Seq_MEFs_Mouse0.73274815
166TP63_22573176_ChIP-Seq_HFKS_Human0.72986098
167CREB1_26743006_Chip-Seq_LNCaP_Human0.72658923
168* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.71902716
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71790060
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71330547
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71171824
172RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71047320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.71058628
2MP0005377_hearing/vestibular/ear_phenot4.55315497
3MP0003878_abnormal_ear_physiology4.55315497
4MP0005360_urolithiasis4.41842326
5* MP0003866_abnormal_defecation3.62453232
6MP0005257_abnormal_intraocular_pressure3.44318377
7MP0005365_abnormal_bile_salt3.42698813
8MP0002277_abnormal_respiratory_mucosa3.32274260
9MP0000462_abnormal_digestive_system3.10264162
10MP0010352_gastrointestinal_tract_polyps3.07369087
11MP0001873_stomach_inflammation2.94999673
12MP0000566_synostosis2.90933078
13MP0002822_catalepsy2.84941074
14MP0010155_abnormal_intestine_physiology2.78588989
15MP0001188_hyperpigmentation2.70555860
16MP0010234_abnormal_vibrissa_follicle2.70042748
17* MP0001663_abnormal_digestive_system2.58779320
18MP0001664_abnormal_digestion2.55534352
19* MP0005381_digestive/alimentary_phenotyp2.47880546
20MP0001666_abnormal_nutrient_absorption2.41747558
21* MP0000490_abnormal_crypts_of2.41496408
22MP0002132_abnormal_respiratory_system2.18533647
23MP0005670_abnormal_white_adipose2.13859609
24MP0009379_abnormal_foot_pigmentation2.13246634
25MP0003283_abnormal_digestive_organ2.11785537
26MP0004264_abnormal_extraembryonic_tissu2.10827041
27MP0008004_abnormal_stomach_pH2.10775324
28MP0002009_preneoplasia2.09798866
29MP0006292_abnormal_olfactory_placode2.00720027
30MP0003879_abnormal_hair_cell1.83849381
31MP0002138_abnormal_hepatobiliary_system1.83768622
32* MP0000477_abnormal_intestine_morphology1.81343182
33MP0003252_abnormal_bile_duct1.79648381
34MP0003136_yellow_coat_color1.79269424
35MP0005409_darkened_coat_color1.71761338
36MP0005310_abnormal_salivary_gland1.67497482
37MP0002163_abnormal_gland_morphology1.65244543
38MP0005174_abnormal_tail_pigmentation1.64474511
39MP0001986_abnormal_taste_sensitivity1.61959336
40MP0004381_abnormal_hair_follicle1.61714417
41MP0003315_abnormal_perineum_morphology1.61401804
42MP0004147_increased_porphyrin_level1.58023836
43MP0002796_impaired_skin_barrier1.56387515
44MP0009643_abnormal_urine_homeostasis1.49723660
45MP0004043_abnormal_pH_regulation1.47517327
46MP0000538_abnormal_urinary_bladder1.47368214
47MP0005167_abnormal_blood-brain_barrier1.46442197
48MP0003941_abnormal_skin_development1.46276059
49MP0009840_abnormal_foam_cell1.46140518
50MP0000678_abnormal_parathyroid_gland1.42897167
51MP0000470_abnormal_stomach_morphology1.42751991
52MP0002148_abnormal_hypersensitivity_rea1.39818315
53* MP0001765_abnormal_ion_homeostasis1.38632730
54MP0003880_abnormal_central_pattern1.34276147
55MP0000613_abnormal_salivary_gland1.33042807
56MP0000465_gastrointestinal_hemorrhage1.32344189
57MP0009785_altered_susceptibility_to1.29111082
58MP0000230_abnormal_systemic_arterial1.28201420
59MP0000537_abnormal_urethra_morphology1.27945608
60MP0002136_abnormal_kidney_physiology1.24343865
61MP0000015_abnormal_ear_pigmentation1.23654444
62MP0000372_irregular_coat_pigmentation1.16373391
63MP0010329_abnormal_lipoprotein_level1.15876140
64MP0002098_abnormal_vibrissa_morphology1.15274074
65MP0001764_abnormal_homeostasis1.09867948
66MP0005367_renal/urinary_system_phenotyp1.08183146
67MP0000516_abnormal_urinary_system1.08183146
68MP0009697_abnormal_copulation1.07272084
69MP0001346_abnormal_lacrimal_gland1.05690834
70MP0005501_abnormal_skin_physiology1.05407070
71MP0005332_abnormal_amino_acid1.04701025
72MP0001756_abnormal_urination1.04238431
73MP0003303_peritoneal_inflammation1.04049643
74MP0005166_decreased_susceptibility_to1.03377466
75MP0005319_abnormal_enzyme/_coenzyme0.98048355
76MP0005025_abnormal_response_to0.97218477
77MP0003724_increased_susceptibility_to0.97016404
78MP0005645_abnormal_hypothalamus_physiol0.96251126
79MP0002118_abnormal_lipid_homeostasis0.96232077
80MP0005171_absent_coat_pigmentation0.92639059
81MP0002006_tumorigenesis0.92518423
82MP0000609_abnormal_liver_physiology0.92492341
83MP0005379_endocrine/exocrine_gland_phen0.92120663
84MP0005671_abnormal_response_to0.92107435
85MP0004742_abnormal_vestibular_system0.91948115
86MP0010386_abnormal_urinary_bladder0.89200157
87MP0005666_abnormal_adipose_tissue0.88818324
88MP0005075_abnormal_melanosome_morpholog0.88550648
89MP0003938_abnormal_ear_development0.85176408
90MP0002095_abnormal_skin_pigmentation0.84122896
91MP0003453_abnormal_keratinocyte_physiol0.83322965
92MP0004484_altered_response_of0.82796222
93MP0005165_increased_susceptibility_to0.81800456
94MP0002971_abnormal_brown_adipose0.81700167
95MP0010678_abnormal_skin_adnexa0.80921397
96MP0002876_abnormal_thyroid_physiology0.80092293
97MP0000681_abnormal_thyroid_gland0.79202395
98MP0001800_abnormal_humoral_immune0.78441512
99MP0003300_gastrointestinal_ulcer0.78298618
100MP0002452_abnormal_antigen_presenting0.78035384
101* MP0005636_abnormal_mineral_homeostasis0.77424320
102MP0003183_abnormal_peptide_metabolism0.76878737
103MP0008872_abnormal_physiological_respon0.76682446
104MP0001819_abnormal_immune_cell0.76510167
105MP0006082_CNS_inflammation0.75281268
106MP0002896_abnormal_bone_mineralization0.75219042
107MP0006276_abnormal_autonomic_nervous0.74604788
108MP0001485_abnormal_pinna_reflex0.74467784
109MP0004782_abnormal_surfactant_physiolog0.73421526
110MP0005085_abnormal_gallbladder_physiolo0.72776428
111MP0001440_abnormal_grooming_behavior0.72727492
112MP0000383_abnormal_hair_follicle0.71993482
113MP0009764_decreased_sensitivity_to0.71715061
114MP0001963_abnormal_hearing_physiology0.71651098
115MP0001845_abnormal_inflammatory_respons0.71607498
116MP0000049_abnormal_middle_ear0.71396972
117MP0002420_abnormal_adaptive_immunity0.71245173
118MP0003705_abnormal_hypodermis_morpholog0.70440951
119MP0004019_abnormal_vitamin_homeostasis0.69749446
120MP0003693_abnormal_embryo_hatching0.69502173
121MP0009115_abnormal_fat_cell0.69364618
122MP0001501_abnormal_sleep_pattern0.69309138
123MP0001790_abnormal_immune_system0.68825582
124MP0005387_immune_system_phenotype0.68825582
125MP0005584_abnormal_enzyme/coenzyme_acti0.68695514
126MP0001849_ear_inflammation0.68545526
127MP0000467_abnormal_esophagus_morphology0.68472435
128MP0003385_abnormal_body_wall0.68436430
129MP0005451_abnormal_body_composition0.68203725
130MP0000026_abnormal_inner_ear0.66975382
131MP0002166_altered_tumor_susceptibility0.66356638
132MP0000762_abnormal_tongue_morphology0.65802059
133MP0008875_abnormal_xenobiotic_pharmacok0.65566248
134MP0004947_skin_inflammation0.62273837
135MP0001216_abnormal_epidermal_layer0.62038841
136MP0003191_abnormal_cellular_cholesterol0.61793734
137MP0003806_abnormal_nucleotide_metabolis0.60952689
138MP0005448_abnormal_energy_balance0.59274612
139MP0009780_abnormal_chondrocyte_physiolo0.57657430
140MP0004858_abnormal_nervous_system0.57040804
141MP0009333_abnormal_splenocyte_physiolog0.53858462
142* MP0009642_abnormal_blood_homeostasis0.53058849
143MP0005058_abnormal_lysosome_morphology0.52520347
144MP0000377_abnormal_hair_follicle0.51465337
145MP0003567_abnormal_fetal_cardiomyocyte0.45673763

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)5.87361418
2* Hyperactive renin-angiotensin system (HP:0000841)5.30713495
3Ileus (HP:0002595)5.13444298
4Prostate neoplasm (HP:0100787)4.70185048
5Chronic diarrhea (HP:0002028)4.26817854
6Congenital sensorineural hearing impairment (HP:0008527)4.21587151
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19141400
8Cheilitis (HP:0100825)4.14995410
9Intrahepatic cholestasis (HP:0001406)3.86235748
10Right ventricular cardiomyopathy (HP:0011663)3.70612723
11Amelogenesis imperfecta (HP:0000705)3.67480236
12Abnormality of the vitamin B12 metabolism (HP:0004341)3.66164099
13Abnormality of dental color (HP:0011073)3.65736378
14Fat malabsorption (HP:0002630)3.55068727
15Alopecia of scalp (HP:0002293)3.45166778
16* Alkalosis (HP:0001948)3.43590654
17Flat capital femoral epiphysis (HP:0003370)3.41225293
18Visceral angiomatosis (HP:0100761)3.39859959
19Abnormality of vitamin B metabolism (HP:0004340)3.39404986
20Hyperkalemia (HP:0002153)3.35515633
21Hemorrhage of the eye (HP:0011885)3.26361873
22Parakeratosis (HP:0001036)3.26241131
23Flat acetabular roof (HP:0003180)3.16404472
24Abnormal biliary tract morphology (HP:0012440)3.16283775
25Conjugated hyperbilirubinemia (HP:0002908)3.13616429
26Cone-rod dystrophy (HP:0000548)3.11630344
27Symphalangism affecting the phalanges of the hand (HP:0009773)3.09204399
28Hemangiomatosis (HP:0007461)3.05992005
29Abnormality of carpal bone ossification (HP:0006257)2.98041012
30Petechiae (HP:0000967)2.97680763
31Malnutrition (HP:0004395)2.96790365
32Reduced antithrombin III activity (HP:0001976)2.92929523
33Vertebral hypoplasia (HP:0008417)2.92256434
34Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92256434
35* Abnormality of renin-angiotensin system (HP:0000847)2.88194150
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.86532325
37Abnormal cartilage morphology (HP:0002763)2.83784057
38Abnormality of vitamin metabolism (HP:0100508)2.83289020
39Abnormality of the phalanges of the hallux (HP:0010057)2.82063233
40Abnormal tarsal ossification (HP:0008369)2.80790222
41Thin bony cortex (HP:0002753)2.78625023
42Vertebral clefting (HP:0008428)2.77998722
43Abnormal vertebral ossification (HP:0100569)2.76698069
44Unilateral renal agenesis (HP:0000122)2.72160608
45Large earlobe (HP:0009748)2.71561476
46Abnormal ciliary motility (HP:0012262)2.71096860
47Renal tubular acidosis (HP:0001947)2.69586148
48Abnormality of the 1st metacarpal (HP:0010009)2.64664897
49Flattened epiphyses (HP:0003071)2.64461392
50Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.63246482
51Irregular epiphyses (HP:0010582)2.62547595
52Absent/shortened dynein arms (HP:0200106)2.61168219
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.61168219
54Ureteral stenosis (HP:0000071)2.57865531
55Pustule (HP:0200039)2.54035463
56Nonprogressive disorder (HP:0003680)2.51012649
57Abnormality of the prostate (HP:0008775)2.49239068
58Ureteral obstruction (HP:0006000)2.48806024
59Hyperphosphatemia (HP:0002905)2.47133133
60Confusion (HP:0001289)2.46887604
61Aplasia cutis congenita (HP:0001057)2.46558688
62* Abnormality of potassium homeostasis (HP:0011042)2.41827854
63Palpitations (HP:0001962)2.41725015
64* Abdominal distention (HP:0003270)2.41434024
65Hyperammonemia (HP:0001987)2.40357309
66* Hyperaldosteronism (HP:0000859)2.36701178
67Acanthocytosis (HP:0001927)2.36646979
68Neonatal short-limb short stature (HP:0008921)2.36409564
69Gastrointestinal dysmotility (HP:0002579)2.36333185
70Biliary tract neoplasm (HP:0100574)2.33110991
71Vacuolated lymphocytes (HP:0001922)2.32329539
72Eczematoid dermatitis (HP:0000976)2.31571159
73Hypotension (HP:0002615)2.30569435
74Breech presentation (HP:0001623)2.30075940
75Patchy hypopigmentation of hair (HP:0011365)2.29996093
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27098650
77Dicarboxylic aciduria (HP:0003215)2.27098650
78Focal segmental glomerulosclerosis (HP:0000097)2.25942340
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23964372
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.23809376
81* Metabolic alkalosis (HP:0200114)2.21721590
82Abnormal hair laboratory examination (HP:0003328)2.18362099
83Hydroxyprolinuria (HP:0003080)2.16169198
84Abnormality of proline metabolism (HP:0010907)2.16169198
85Hoarse voice (HP:0001609)2.15829502
86Abnormal respiratory motile cilium physiology (HP:0012261)2.14038508
87Cupped ribs (HP:0000887)2.13703283
88Short middle phalanx of finger (HP:0005819)2.12362310
89Protuberant abdomen (HP:0001538)2.12089964
90Villous atrophy (HP:0011473)2.11813122
91Abnormality of small intestinal villus morphology (HP:0011472)2.11813122
92Autoimmune hemolytic anemia (HP:0001890)2.11173753
93Progressive sensorineural hearing impairment (HP:0000408)2.09794995
94Type I transferrin isoform profile (HP:0003642)2.07454247
95Abnormal hand bone ossification (HP:0010660)2.05665045
96* Hypokalemia (HP:0002900)2.04301267
97* Hyponatremia (HP:0002902)2.01462155
98Severe short stature (HP:0003510)2.00934925
99Systemic lupus erythematosus (HP:0002725)1.99874581
100Septate vagina (HP:0001153)1.99404071
101Enlarged epiphyses (HP:0010580)1.99403336
102Abnormality of the 2nd finger (HP:0004100)1.99394203
103Wide cranial sutures (HP:0010537)1.99255754
104Short tibia (HP:0005736)1.98893332
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97023128
106Follicular hyperkeratosis (HP:0007502)1.96569039
107Widely patent fontanelles and sutures (HP:0004492)1.95519586
108Hypobetalipoproteinemia (HP:0003563)1.95152494
109Curly hair (HP:0002212)1.94738303
110* Dehydration (HP:0001944)1.94735752
111Neoplasm of the rectum (HP:0100743)1.93751209
112Aplasia/hypoplasia of the femur (HP:0005613)1.93336278
113Rectal prolapse (HP:0002035)1.92139869
114* Abnormality of chloride homeostasis (HP:0011422)1.92117435
115Abnormality of magnesium homeostasis (HP:0004921)1.91018886
116Abnormal respiratory motile cilium morphology (HP:0005938)1.90999077
117Abnormal respiratory epithelium morphology (HP:0012253)1.90999077
118Abnormal ossification of hand bones (HP:0005921)1.90782740
119Ectropion (HP:0000656)1.90731161
120Absent eyebrow (HP:0002223)1.90641986
121Spinal cord compression (HP:0002176)1.90491708
122Alveolar cell carcinoma (HP:0006519)1.88675608
123Syncope (HP:0001279)1.88514847
124Plantar hyperkeratosis (HP:0007556)1.86889740
125Hip contracture (HP:0003273)1.85108921
126White forelock (HP:0002211)1.85067143
127Delayed epiphyseal ossification (HP:0002663)1.83744423
128Bone pain (HP:0002653)1.82479326
129Tetany (HP:0001281)1.82167186
130Abnormality of the costochondral junction (HP:0000919)1.80867839
131Bradycardia (HP:0001662)1.80297711
132Cerebral palsy (HP:0100021)1.80067016
133Conical tooth (HP:0000698)1.79969535
134Short phalanx of the thumb (HP:0009660)1.76793004
135Pigmentary retinal degeneration (HP:0001146)1.75999171
136Increased circulating renin level (HP:0000848)1.75386933
137Glomerulosclerosis (HP:0000096)1.74522074
138Woolly hair (HP:0002224)1.74295610
139Recurrent pneumonia (HP:0006532)1.74225034
140Pili torti (HP:0003777)1.74106063
141Metabolic acidosis (HP:0001942)1.73742621
142Abnormal foot bone ossification (HP:0010675)1.73146373
143Late onset (HP:0003584)1.72984285
144Mildly elevated creatine phosphokinase (HP:0008180)1.71834016
145Blepharitis (HP:0000498)1.71730630
146Premature loss of primary teeth (HP:0006323)1.70997860
147Hyperparathyroidism (HP:0000843)1.70747989
148Decreased central vision (HP:0007663)1.69998450
149Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68687410
150Osteomalacia (HP:0002749)1.68300073
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67733238
152Recurrent cutaneous fungal infections (HP:0011370)1.67707236
153Chronic mucocutaneous candidiasis (HP:0002728)1.67707236
154Fragile nails (HP:0001808)1.66827117
155Chromosomal breakage induced by crosslinking agents (HP:0003221)1.66102651
156Onycholysis (HP:0001806)1.64507743
157Symptomatic seizures (HP:0011145)1.62549035
158Anhidrosis (HP:0000970)1.61742552
159Progressive hearing impairment (HP:0001730)1.61563111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.74529243
2MST1R4.62571758
3RIPK14.21112239
4MST43.67213382
5PIK3CA3.55657697
6CASK3.37130937
7FRK3.08837594
8LMTK22.91661904
9SIK32.89241479
10TNIK2.78109355
11MYLK2.67685768
12STK392.63187158
13MAP3K102.51478257
14PRKD22.43914417
15ERN12.41256803
16TAOK32.19111024
17PRKG22.17517711
18IRAK32.14901600
19MAP2K22.11250566
20TXK2.07348325
21STK381.92242918
22EPHB21.86863659
23OXSR11.76423496
24YES11.72049046
25PTK61.68357937
26MAP3K141.63283046
27MAPK151.48991028
28NME11.48109397
29RIPK41.46713225
30PDK21.46125881
31IRAK41.43002942
32GRK61.40884464
33NLK1.36838142
34WNK41.33214186
35MUSK1.29646234
36TEC1.28771224
37DMPK1.27613222
38CDK81.20265290
39NUAK11.18982520
40AKT31.17934893
41MAP3K121.17515387
42CLK11.15777148
43INSRR1.15555626
44MKNK21.13739891
45PIK3CG1.08950097
46IKBKE1.06599041
47GRK71.06114031
48SIK21.02456115
49GRK10.97890120
50EIF2AK20.95303909
51DDR20.93729739
52PRKAA20.93611471
53PDPK10.89659925
54FGFR40.87997791
55STK38L0.86595280
56ADRBK20.85311914
57MAPK110.83152858
58CDK30.81829857
59EPHA30.81652205
60BMPR1B0.80624398
61TLK10.78560177
62ZAK0.76293235
63ABL20.75893879
64TBK10.74789941
65EPHB10.74372323
66MET0.73807923
67MARK30.73756588
68MAP3K20.71166197
69TAOK10.70304658
70MATK0.68658515
71STK110.68186683
72TYK20.67782432
73BLK0.65727786
74MAP3K10.65179597
75SIK10.64296949
76FGFR30.64253104
77BMPR20.63334396
78PDK10.63064539
79MAP3K130.62827969
80TESK10.62696281
81EPHA40.58248073
82PAK40.57154379
83FGR0.57152212
84MAPK130.56474544
85MAPKAPK50.56232870
86ITK0.55999651
87CSK0.55986246
88SGK20.54788300
89MAP2K70.53138848
90IKBKB0.52912632
91CDK90.52527009
92FER0.52522142
93MAP2K10.52325214
94PTK20.51845568
95TNK20.51775095
96CAMK2D0.50837623
97MAPKAPK30.49850882
98EPHA20.49176351
99CDC42BPA0.46719844
100PRKACG0.46096324
101STK100.45781375
102KSR20.45751285
103PRKCI0.44943281
104PIM20.44603188
105PRKAA10.43103859
106MAP2K60.43037598
107LYN0.42952351
108MAP3K70.41564839
109ERBB20.40998398
110PIM10.40585838
111TGFBR20.39466012
112TESK20.39461785
113SRC0.38870736
114MAP4K10.38177898
115CAMK2B0.36607321
116RET0.36488480
117PRKG10.36026553
118MAPKAPK20.35810205
119SRPK10.35279713
120PRKCA0.34773649
121CAMK10.33492667
122IRAK10.32250138
123TSSK60.31639587
124PRPF4B0.31617171
125MKNK10.30011277
126SGK30.28498895
127CAMK2G0.27983588
128CSNK1A10.26723588
129VRK10.26669623
130STK240.25340478
131IRAK20.25119087
132FYN0.24849562
133RPS6KA20.24616178
134DYRK1B0.23739896
135NEK60.22840180
136JAK20.21312740
137SMG10.20444281
138PDGFRA0.18865938
139PRKCD0.18641328
140TRIB30.17685360
141CDK190.16241804
142PRKCZ0.15665131
143PRKCB0.14898886
144EEF2K0.14187040
145PRKCQ0.13258709
146BCR0.13092559
147BMX0.12783907
148IGF1R0.12437144
149WNK10.12070406
150MAP3K110.11533999
151ZAP700.10195342
152ROCK10.09948571
153CDK60.08809379
154MAP3K80.08310636
155RPS6KB10.07111689
156MAPK70.07031484

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.03884106
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006014.48189208
3Nitrogen metabolism_Homo sapiens_hsa009104.30165664
4Cyanoamino acid metabolism_Homo sapiens_hsa004604.05237059
5* Mineral absorption_Homo sapiens_hsa049783.84746074
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.57329925
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.17300845
8Caffeine metabolism_Homo sapiens_hsa002322.81466443
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.52104283
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.29758546
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.21371455
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.14701693
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.06693111
14Retinol metabolism_Homo sapiens_hsa008301.91564218
15Sphingolipid metabolism_Homo sapiens_hsa006001.74407867
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73421537
17PPAR signaling pathway_Homo sapiens_hsa033201.71478018
18Arginine biosynthesis_Homo sapiens_hsa002201.70063516
19Fatty acid degradation_Homo sapiens_hsa000711.68790800
20Renin-angiotensin system_Homo sapiens_hsa046141.57328220
21Fat digestion and absorption_Homo sapiens_hsa049751.53418422
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51411212
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.38180509
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.33667975
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.27105627
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22096920
27Thyroid cancer_Homo sapiens_hsa052161.21912778
28Other glycan degradation_Homo sapiens_hsa005111.21670977
29Histidine metabolism_Homo sapiens_hsa003401.20483265
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.16733832
31Vitamin digestion and absorption_Homo sapiens_hsa049771.16315279
32Ether lipid metabolism_Homo sapiens_hsa005651.14989244
33Protein digestion and absorption_Homo sapiens_hsa049741.14557110
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13525897
35Galactose metabolism_Homo sapiens_hsa000521.11690634
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11582130
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11286949
38Arginine and proline metabolism_Homo sapiens_hsa003301.10015153
39Fructose and mannose metabolism_Homo sapiens_hsa000511.05362896
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05048714
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04488373
42Bile secretion_Homo sapiens_hsa049761.03866987
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03407387
44Arachidonic acid metabolism_Homo sapiens_hsa005901.02235585
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02140969
46Tryptophan metabolism_Homo sapiens_hsa003801.02010066
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01647997
48Hematopoietic cell lineage_Homo sapiens_hsa046401.00899647
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98688881
50Primary immunodeficiency_Homo sapiens_hsa053400.94825342
51Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92404254
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88734854
53Salivary secretion_Homo sapiens_hsa049700.88596976
54* Pancreatic secretion_Homo sapiens_hsa049720.86694748
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85380641
56Graft-versus-host disease_Homo sapiens_hsa053320.84868873
57Influenza A_Homo sapiens_hsa051640.82012386
58Salmonella infection_Homo sapiens_hsa051320.81813344
59Measles_Homo sapiens_hsa051620.81059024
60Linoleic acid metabolism_Homo sapiens_hsa005910.79877005
61Starch and sucrose metabolism_Homo sapiens_hsa005000.78932788
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76918496
63Hepatitis C_Homo sapiens_hsa051600.76894574
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76462718
65African trypanosomiasis_Homo sapiens_hsa051430.75032202
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74412417
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72963323
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72643931
69Inositol phosphate metabolism_Homo sapiens_hsa005620.72070667
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.71492521
71Fatty acid metabolism_Homo sapiens_hsa012120.69513705
72Folate biosynthesis_Homo sapiens_hsa007900.66143245
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64845868
74Adherens junction_Homo sapiens_hsa045200.64663921
75Butanoate metabolism_Homo sapiens_hsa006500.64065931
76Taste transduction_Homo sapiens_hsa047420.62764042
77Tight junction_Homo sapiens_hsa045300.61098963
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61064700
79ABC transporters_Homo sapiens_hsa020100.57794827
80Oxidative phosphorylation_Homo sapiens_hsa001900.55334785
81Phenylalanine metabolism_Homo sapiens_hsa003600.53940631
82Propanoate metabolism_Homo sapiens_hsa006400.53833335
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53769470
84Leishmaniasis_Homo sapiens_hsa051400.53198716
85Pertussis_Homo sapiens_hsa051330.52944155
86Nicotine addiction_Homo sapiens_hsa050330.51601427
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50538927
88Homologous recombination_Homo sapiens_hsa034400.50118249
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49340056
90Tyrosine metabolism_Homo sapiens_hsa003500.48517003
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46639791
92Acute myeloid leukemia_Homo sapiens_hsa052210.46584027
93Choline metabolism in cancer_Homo sapiens_hsa052310.46054469
94Pyruvate metabolism_Homo sapiens_hsa006200.45952929
95Peroxisome_Homo sapiens_hsa041460.45929271
96Sulfur relay system_Homo sapiens_hsa041220.45832858
97Autoimmune thyroid disease_Homo sapiens_hsa053200.45624754
98Osteoclast differentiation_Homo sapiens_hsa043800.44020579
99TNF signaling pathway_Homo sapiens_hsa046680.42093727
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41684764
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.41417370
102Renin secretion_Homo sapiens_hsa049240.41261534
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.41036955
104Herpes simplex infection_Homo sapiens_hsa051680.40212402
105Chemical carcinogenesis_Homo sapiens_hsa052040.39950184
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38110968
107Ovarian steroidogenesis_Homo sapiens_hsa049130.36284752
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35186906
109Calcium signaling pathway_Homo sapiens_hsa040200.34990074
110Tuberculosis_Homo sapiens_hsa051520.34208508
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34199480
112Glutathione metabolism_Homo sapiens_hsa004800.32909071
113N-Glycan biosynthesis_Homo sapiens_hsa005100.32427839
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.32411208
115Glycerolipid metabolism_Homo sapiens_hsa005610.32242424
116Prostate cancer_Homo sapiens_hsa052150.31859247
117Alzheimers disease_Homo sapiens_hsa050100.31654525
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31491566
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31260479
120Carbon metabolism_Homo sapiens_hsa012000.29842308
121Asthma_Homo sapiens_hsa053100.28859686
122Allograft rejection_Homo sapiens_hsa053300.28533424
123Fanconi anemia pathway_Homo sapiens_hsa034600.28340756
124Toxoplasmosis_Homo sapiens_hsa051450.28334473
125Gastric acid secretion_Homo sapiens_hsa049710.28254017
126Insulin resistance_Homo sapiens_hsa049310.26328456
127Thyroid hormone synthesis_Homo sapiens_hsa049180.24007705
128Metabolic pathways_Homo sapiens_hsa011000.18277498
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.18267256
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17289544
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.13766858
132Fatty acid biosynthesis_Homo sapiens_hsa000610.10096212
133GnRH signaling pathway_Homo sapiens_hsa049120.08519972
134Type I diabetes mellitus_Homo sapiens_hsa049400.06423471
135Fatty acid elongation_Homo sapiens_hsa000620.05875937
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.04595724
137Vibrio cholerae infection_Homo sapiens_hsa051100.02810275
138Insulin secretion_Homo sapiens_hsa049110.01498534
139AMPK signaling pathway_Homo sapiens_hsa04152-0.0339283
140Glucagon signaling pathway_Homo sapiens_hsa04922-0.0299145
141Staphylococcus aureus infection_Homo sapiens_hsa05150-0.0054768

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