SLC26A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)6.44868440
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.41498572
3virion attachment to host cell (GO:0019062)5.95459936
4adhesion of symbiont to host cell (GO:0044650)5.95459936
5phospholipid efflux (GO:0033700)5.70432251
6positive regulation of lipoprotein lipase activity (GO:0051006)5.70382510
7positive regulation of triglyceride lipase activity (GO:0061365)5.70382510
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.69603633
9plasma lipoprotein particle assembly (GO:0034377)5.54121202
10protein carboxylation (GO:0018214)5.51955055
11peptidyl-glutamic acid carboxylation (GO:0017187)5.51955055
12protein-lipid complex assembly (GO:0065005)5.35297744
13regulation of cholesterol esterification (GO:0010872)5.32400732
14negative regulation of fibrinolysis (GO:0051918)5.17503910
15flavonoid metabolic process (GO:0009812)5.11374159
16regulation of triglyceride catabolic process (GO:0010896)5.09057965
17very-low-density lipoprotein particle assembly (GO:0034379)5.03333766
18adhesion of symbiont to host (GO:0044406)5.00400431
19digestion (GO:0007586)4.92073090
20lipoprotein metabolic process (GO:0042157)4.87479429
21cholesterol efflux (GO:0033344)4.87213052
22modified amino acid transport (GO:0072337)4.84937037
23* digestive system process (GO:0022600)4.72148208
24drug catabolic process (GO:0042737)4.70190499
25actin filament depolymerization (GO:0030042)4.66178638
26purine nucleotide salvage (GO:0032261)4.64365050
27regulation of apoptotic cell clearance (GO:2000425)4.53726671
28hormone catabolic process (GO:0042447)4.48588208
29reverse cholesterol transport (GO:0043691)4.45926529
30glucose 6-phosphate metabolic process (GO:0051156)4.44537421
31cholesterol transport (GO:0030301)4.44463134
32sterol transport (GO:0015918)4.44463134
33lipoprotein transport (GO:0042953)4.37820872
34oligosaccharide catabolic process (GO:0009313)4.36517663
35diacylglycerol metabolic process (GO:0046339)4.35454355
36pinocytosis (GO:0006907)4.27217879
37regulation of bile acid biosynthetic process (GO:0070857)4.23327685
38proline biosynthetic process (GO:0006561)4.15526631
39peptide catabolic process (GO:0043171)4.13350512
40regulation of fibrinolysis (GO:0051917)4.07155663
41plasma lipoprotein particle clearance (GO:0034381)4.05486976
42plasma lipoprotein particle organization (GO:0071827)4.05422135
43protein-lipid complex subunit organization (GO:0071825)4.04085873
44cholesterol homeostasis (GO:0042632)4.03747301
45basement membrane organization (GO:0071711)3.99942561
46sterol homeostasis (GO:0055092)3.99895146
47low-density lipoprotein particle remodeling (GO:0034374)3.96510003
48protein-lipid complex remodeling (GO:0034368)3.89077977
49macromolecular complex remodeling (GO:0034367)3.89077977
50plasma lipoprotein particle remodeling (GO:0034369)3.89077977
51regulation of protein activation cascade (GO:2000257)3.81135954
52drinking behavior (GO:0042756)3.80333326
53positive regulation of triglyceride metabolic process (GO:0090208)3.79973937
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.78093777
553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.78093777
56negative regulation of sterol transport (GO:0032372)3.77742930
57negative regulation of cholesterol transport (GO:0032375)3.77742930
58proline metabolic process (GO:0006560)3.76977889
59regulation of complement activation (GO:0030449)3.76676878
60peptide hormone processing (GO:0016486)3.76210822
61response to hepatocyte growth factor (GO:0035728)3.72488562
62cellular response to hepatocyte growth factor stimulus (GO:0035729)3.72488562
63positive regulation of fatty acid biosynthetic process (GO:0045723)3.65855748
64low-density lipoprotein particle clearance (GO:0034383)3.65314583
65negative regulation of digestive system process (GO:0060457)3.63381839
66phospholipid homeostasis (GO:0055091)3.60382054
67phenylpropanoid metabolic process (GO:0009698)3.55061574
68regulation of plasminogen activation (GO:0010755)3.52910504
69high-density lipoprotein particle remodeling (GO:0034375)3.47678185
70mannose metabolic process (GO:0006013)3.45823040
71Golgi transport vesicle coating (GO:0048200)3.41579230
72COPI coating of Golgi vesicle (GO:0048205)3.41579230
73activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.39312088
74regulation of cholesterol biosynthetic process (GO:0045540)3.36864822
75negative regulation of fatty acid biosynthetic process (GO:0045717)3.35026920
76bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31352811
77NADH metabolic process (GO:0006734)3.28782723
78glutamine family amino acid biosynthetic process (GO:0009084)3.28377283
79cellular carbohydrate catabolic process (GO:0044275)3.28192557
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.27078680
81transcytosis (GO:0045056)3.25900930
82regulation of cholesterol homeostasis (GO:2000188)3.25206291
83regulation of lipoprotein metabolic process (GO:0050746)3.24126154
84UDP-N-acetylglucosamine metabolic process (GO:0006047)3.22586539
85sphingomyelin metabolic process (GO:0006684)3.19893016
86mature B cell differentiation involved in immune response (GO:0002313)3.18557023
87negative regulation of lipase activity (GO:0060192)3.17817214
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.17076749
89positive regulation of T cell differentiation in thymus (GO:0033089)3.15667615
90nucleobase catabolic process (GO:0046113)3.13459146
91maintenance of gastrointestinal epithelium (GO:0030277)3.12057819
92protein retention in ER lumen (GO:0006621)3.10591318
93mitotic chromosome condensation (GO:0007076)3.02905243
94L-alpha-amino acid transmembrane transport (GO:1902475)3.02371872
95regulation of sterol transport (GO:0032371)3.00682427
96regulation of cholesterol transport (GO:0032374)3.00682427
97fructose metabolic process (GO:0006000)3.00549602
98regulation of fatty acid biosynthetic process (GO:0042304)3.00426987
99response to hydroperoxide (GO:0033194)3.00424021
100neutral amino acid transport (GO:0015804)3.00237840
101positive regulation of steroid metabolic process (GO:0045940)2.99104019
102cytidine deamination (GO:0009972)2.96333347
103cytidine metabolic process (GO:0046087)2.96333347
104cytidine catabolic process (GO:0006216)2.96333347
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.96053186
106regulation of digestive system process (GO:0044058)2.95472178
107positive regulation of lipid catabolic process (GO:0050996)2.95288305
108positive regulation of p38MAPK cascade (GO:1900745)2.93349004
109histamine secretion (GO:0001821)2.92402935
110negative regulation of thymocyte apoptotic process (GO:0070244)2.91499459
111thyroid hormone metabolic process (GO:0042403)2.88433012
112positive regulation of extracellular matrix organization (GO:1903055)2.87548199
113embryonic process involved in female pregnancy (GO:0060136)2.87125928
114regulation of Golgi to plasma membrane protein transport (GO:0042996)2.86573122
115lung epithelium development (GO:0060428)2.86379320
116cellular zinc ion homeostasis (GO:0006882)2.84198384
117striated muscle atrophy (GO:0014891)2.83024467
1184-hydroxyproline metabolic process (GO:0019471)2.82873366
119beta-amyloid metabolic process (GO:0050435)2.81540419
120nucleotide salvage (GO:0043173)2.79571201
121GDP-mannose metabolic process (GO:0019673)2.78585133
122Peyers patch development (GO:0048541)2.76382528
123mucosal-associated lymphoid tissue development (GO:0048537)2.76382528
124heterochromatin organization (GO:0070828)2.75884952
125lipid homeostasis (GO:0055088)2.74356849
126regulation of translational fidelity (GO:0006450)2.74085464
127blood coagulation, intrinsic pathway (GO:0007597)2.72415098
128glucan catabolic process (GO:0009251)2.72074435
129regulation of cholesterol metabolic process (GO:0090181)2.71773636
130intestinal epithelial cell development (GO:0060576)2.70831350
131positive regulation of hormone biosynthetic process (GO:0046886)2.70773057
132activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.69468296
133alpha-linolenic acid metabolic process (GO:0036109)2.69412055
134positive regulation of hormone metabolic process (GO:0032352)2.69397964
135positive regulation of nuclease activity (GO:0032075)2.67992673
136urea metabolic process (GO:0019627)2.67679167
137regulation of extracellular matrix organization (GO:1903053)2.66438187
138homocysteine metabolic process (GO:0050667)2.66345335
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.66305363
140focal adhesion assembly (GO:0048041)2.66223320
141cell-substrate adherens junction assembly (GO:0007045)2.66223320
142regulation of actin nucleation (GO:0051125)2.65493003
143cellular polysaccharide catabolic process (GO:0044247)2.65421113
144regulation of extracellular matrix disassembly (GO:0010715)2.64299739
145urea cycle (GO:0000050)2.63857436
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63466628
147vitamin transmembrane transport (GO:0035461)2.59233014
148complement activation, alternative pathway (GO:0006957)2.59063574
149response to vitamin A (GO:0033189)2.57411609
150neutral lipid catabolic process (GO:0046461)2.52154475
151acylglycerol catabolic process (GO:0046464)2.52154475
152COPII vesicle coating (GO:0048208)2.50453138
153receptor catabolic process (GO:0032801)2.49121917
154nucleotide-sugar biosynthetic process (GO:0009226)2.48840730
155hyaluronan metabolic process (GO:0030212)2.47345350
156cellular response to epidermal growth factor stimulus (GO:0071364)2.47317500
157acute-phase response (GO:0006953)2.46014932
158positive regulation of osteoblast proliferation (GO:0033690)2.42238273
159glycosphingolipid catabolic process (GO:0046479)2.42216495
160adherens junction assembly (GO:0034333)2.41678702
161intestinal cholesterol absorption (GO:0030299)12.8446171
162* intestinal absorption (GO:0050892)11.2504738
163angiotensin maturation (GO:0002003)10.3059176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.93129955
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.83358110
3E2F7_22180533_ChIP-Seq_HELA_Human3.58460920
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.15189771
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.98328272
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.68276980
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.65830674
8GATA4_25053715_ChIP-Seq_YYC3_Human2.55942973
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.52780269
10GATA6_25053715_ChIP-Seq_YYC3_Human2.49739151
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.49209458
12ZNF263_19887448_ChIP-Seq_K562_Human2.49055321
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.40927034
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.35984423
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.23770361
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.17231763
17MYC_22102868_ChIP-Seq_BL_Human2.15922715
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.12920950
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08573270
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.07573881
21ELK3_25401928_ChIP-Seq_HUVEC_Human2.06503193
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.04363069
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.00088064
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.97829576
25SOX2_20726797_ChIP-Seq_SW620_Human1.95980184
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94407048
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92937370
28* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71685281
29* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69849931
30KLF5_25053715_ChIP-Seq_YYC3_Human1.69324777
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63747561
32GATA2_19941826_ChIP-Seq_K562_Human1.62347040
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.61482707
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61418448
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60819221
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59192932
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58443791
38DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58114131
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55946915
40* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54089806
41AR_21909140_ChIP-Seq_LNCAP_Human1.51490735
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.51106109
43TCF7_22412390_ChIP-Seq_EML_Mouse1.50164522
44NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.48089647
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48012070
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.47214986
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45429442
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43706904
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43640234
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42947542
51RUNX1_27514584_Chip-Seq_MCF-7_Human1.42448024
52MYC_18555785_ChIP-Seq_MESCs_Mouse1.41103261
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40815839
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39675026
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.39478367
56KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39284945
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38685671
58* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.37524335
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37497771
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35345589
61* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35259782
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34996813
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34768930
64* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34655904
65NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34608660
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.34275256
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33848836
68* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33720860
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.33434369
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32238111
71HNF4A_19822575_ChIP-Seq_HepG2_Human1.30492182
72* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30279764
73RACK7_27058665_Chip-Seq_MCF-7_Human1.30202600
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29269145
75NCOR1_26117541_ChIP-Seq_K562_Human1.27578644
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26574881
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.25439559
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.24731819
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24352620
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22646599
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22097261
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21434079
83SPI1_23127762_ChIP-Seq_K562_Human1.21074934
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20475500
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19737563
86TP53_22127205_ChIP-Seq_IMR90_Human1.19691909
87FOXA2_19822575_ChIP-Seq_HepG2_Human1.19421655
88GATA1_22025678_ChIP-Seq_K562_Human1.19060491
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18590018
90* KDM2B_26808549_Chip-Seq_DND41_Human1.18563316
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.17683484
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.16791469
93LXR_22292898_ChIP-Seq_THP-1_Human1.16580457
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.16405495
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16356094
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16305073
97GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15807710
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15580575
99EGR1_19374776_ChIP-ChIP_THP-1_Human1.14413371
100NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14350428
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14118918
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13753581
103* KDM2B_26808549_Chip-Seq_K562_Human1.13311115
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13162472
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.12617037
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12369314
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11699599
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11534595
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11376787
110* RARA_24833708_ChIP-Seq_LIVER_Mouse1.11092307
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10677743
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10656128
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09291368
114* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08686617
115* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06936007
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06894990
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06740060
118* SMC4_20622854_ChIP-Seq_HELA_Human1.06705861
119NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06307724
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05788734
121VDR_24763502_ChIP-Seq_THP-1_Human1.05664879
122EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04489258
123* BCOR_27268052_Chip-Seq_Bcells_Human1.03924905
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.03697838
125ATF3_27146783_Chip-Seq_COLON_Human1.03567193
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03432714
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01808828
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01762906
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01295238
130ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01085894
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00771009
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.99699701
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98902525
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98376833
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97694501
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97350108
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96735465
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95647622
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95564817
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95525076
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95395163
142* BCL6_27268052_Chip-Seq_Bcells_Human0.95035954
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.94714115
144DROSHA_22980978_ChIP-Seq_HELA_Human0.94255991
145SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93699324
146MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90865871
147CLOCK_20551151_ChIP-Seq_293T_Human0.90684360
148CREB1_26743006_Chip-Seq_LNCaP_Human0.89019703
149PHF8_20622854_ChIP-Seq_HELA_Human0.88675939
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.88033919
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87811461
152CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86268345
153GATA1_19941826_ChIP-Seq_K562_Human0.85441896
154VDR_21846776_ChIP-Seq_THP-1_Human0.84741412
155* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82983028
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.82439355
157* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82060092
158ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81532101
159MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81459144
160CTNNB1_20460455_ChIP-Seq_HCT116_Human0.81383383
161* P68_20966046_ChIP-Seq_HELA_Human0.81192283
162TP63_22573176_ChIP-Seq_HFKS_Human0.81125060
163RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.80032685
164SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79994358
165P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78936850
166JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78816722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption7.34525053
2* MP0005360_urolithiasis6.92381010
3MP0009840_abnormal_foam_cell5.60636394
4MP0003183_abnormal_peptide_metabolism4.30733307
5MP0002139_abnormal_hepatobiliary_system3.68378645
6MP0004264_abnormal_extraembryonic_tissu3.42956712
7MP0003252_abnormal_bile_duct3.36429756
8MP0010329_abnormal_lipoprotein_level2.93032746
9MP0005085_abnormal_gallbladder_physiolo2.81865585
10MP0003191_abnormal_cellular_cholesterol2.76688151
11MP0003172_abnormal_lysosome_physiology2.55552632
12MP0000566_synostosis2.48625219
13MP0008438_abnormal_cutaneous_collagen2.48460127
14MP0008875_abnormal_xenobiotic_pharmacok2.48361170
15MP0003866_abnormal_defecation2.42736955
16MP0010234_abnormal_vibrissa_follicle2.36754495
17MP0004147_increased_porphyrin_level2.36249988
18MP0003566_abnormal_cell_adhesion2.33346664
19MP0004272_abnormal_basement_membrane2.29943877
20MP0005084_abnormal_gallbladder_morpholo2.25827577
21MP0005076_abnormal_cell_differentiation2.24056394
22MP0000462_abnormal_digestive_system2.22871575
23MP0003123_paternal_imprinting2.21275548
24MP0003705_abnormal_hypodermis_morpholog2.18660751
25MP0003122_maternal_imprinting2.16652636
26MP0005257_abnormal_intraocular_pressure2.09928718
27MP0005365_abnormal_bile_salt2.07089506
28MP0002254_reproductive_system_inflammat1.97929047
29MP0001849_ear_inflammation1.91519240
30MP0001873_stomach_inflammation1.90480750
31MP0004043_abnormal_pH_regulation1.90136071
32MP0009697_abnormal_copulation1.85746514
33MP0008260_abnormal_autophagy1.80280511
34MP0001915_intracranial_hemorrhage1.79491488
35MP0004019_abnormal_vitamin_homeostasis1.76068118
36MP0010155_abnormal_intestine_physiology1.71835448
37MP0004858_abnormal_nervous_system1.65149178
38MP0003111_abnormal_nucleus_morphology1.64797029
39MP0005448_abnormal_energy_balance1.61156600
40MP0005409_darkened_coat_color1.60430605
41MP0001664_abnormal_digestion1.58888880
42MP0003878_abnormal_ear_physiology1.58343715
43MP0005377_hearing/vestibular/ear_phenot1.58343715
44* MP0001663_abnormal_digestive_system1.54402003
45MP0003300_gastrointestinal_ulcer1.52434063
46MP0005451_abnormal_body_composition1.51128802
47MP0000538_abnormal_urinary_bladder1.50056203
48MP0005332_abnormal_amino_acid1.49656241
49MP0003693_abnormal_embryo_hatching1.47792543
50* MP0005381_digestive/alimentary_phenotyp1.42515000
51MP0001730_embryonic_growth_arrest1.39175061
52MP0010030_abnormal_orbit_morphology1.38895225
53MP0009780_abnormal_chondrocyte_physiolo1.38894769
54MP0000490_abnormal_crypts_of1.38536757
55MP0001661_extended_life_span1.36299123
56MP0002118_abnormal_lipid_homeostasis1.30624547
57MP0000604_amyloidosis1.30294679
58MP0000858_altered_metastatic_potential1.29875161
59MP0004233_abnormal_muscle_weight1.29531802
60MP0004185_abnormal_adipocyte_glucose1.29244766
61MP0000477_abnormal_intestine_morphology1.26061652
62MP0005408_hypopigmentation1.25283362
63MP0010352_gastrointestinal_tract_polyps1.23278045
64MP0004957_abnormal_blastocyst_morpholog1.22354210
65MP0003646_muscle_fatigue1.19997557
66MP0002132_abnormal_respiratory_system1.16624340
67MP0003718_maternal_effect1.14865959
68MP0000609_abnormal_liver_physiology1.14536321
69MP0009384_cardiac_valve_regurgitation1.12445622
70MP0005058_abnormal_lysosome_morphology1.09968594
71MP0002396_abnormal_hematopoietic_system1.08207540
72MP0005464_abnormal_platelet_physiology1.05680651
73MP0001672_abnormal_embryogenesis/_devel1.05115504
74MP0005380_embryogenesis_phenotype1.05115504
75MP0002822_catalepsy1.05112767
76MP0008932_abnormal_embryonic_tissue1.04551829
77MP0002089_abnormal_postnatal_growth/wei1.04203391
78MP0000767_abnormal_smooth_muscle1.04132764
79MP0003984_embryonic_growth_retardation1.03532456
80MP0003315_abnormal_perineum_morphology1.02521237
81MP0000003_abnormal_adipose_tissue1.02003171
82MP0002086_abnormal_extraembryonic_tissu1.01569392
83MP0005023_abnormal_wound_healing1.01054487
84MP0003115_abnormal_respiratory_system0.98413800
85MP0002088_abnormal_embryonic_growth/wei0.96630775
86MP0009672_abnormal_birth_weight0.96076590
87* MP0009643_abnormal_urine_homeostasis0.95399379
88MP0009764_decreased_sensitivity_to0.94987514
89MP0000598_abnormal_liver_morphology0.93166674
90MP0003950_abnormal_plasma_membrane0.91319844
91MP0005266_abnormal_metabolism0.90804317
92MP0002080_prenatal_lethality0.89188134
93MP0009115_abnormal_fat_cell0.89165044
94MP0003329_amyloid_beta_deposits0.85560074
95MP0005666_abnormal_adipose_tissue0.85048068
96MP0005310_abnormal_salivary_gland0.84952931
97MP0002933_joint_inflammation0.84001398
98MP0001697_abnormal_embryo_size0.83610708
99MP0002060_abnormal_skin_morphology0.83027818
100MP0004947_skin_inflammation0.82170964
101MP0002092_abnormal_eye_morphology0.81331499
102MP0005166_decreased_susceptibility_to0.80908033
103MP0003806_abnormal_nucleotide_metabolis0.79518709
104MP0005501_abnormal_skin_physiology0.78814243
105MP0003195_calcinosis0.78527567
106MP0006138_congestive_heart_failure0.78316970
107MP0005319_abnormal_enzyme/_coenzyme0.77887448
108MP0003942_abnormal_urinary_system0.77056539
109MP0003941_abnormal_skin_development0.75906345
110MP0005083_abnormal_biliary_tract0.75865545
111MP0005375_adipose_tissue_phenotype0.74755084
112MP0002148_abnormal_hypersensitivity_rea0.72558025
113MP0010630_abnormal_cardiac_muscle0.71784714
114MP0005167_abnormal_blood-brain_barrier0.71388574
115MP0003091_abnormal_cell_migration0.71199470
116MP0006054_spinal_hemorrhage0.70731230
117MP0009333_abnormal_splenocyte_physiolog0.69781877
118MP0003077_abnormal_cell_cycle0.69703773
119MP0001881_abnormal_mammary_gland0.68511897
120MP0002419_abnormal_innate_immunity0.67444412
121MP0002697_abnormal_eye_size0.66592006
122MP0000350_abnormal_cell_proliferation0.66248834
123MP0010094_abnormal_chromosome_stability0.65616550
124MP0005330_cardiomyopathy0.65256218
125MP0005621_abnormal_cell_physiology0.65185191
126MP0000537_abnormal_urethra_morphology0.64159685
127MP0002998_abnormal_bone_remodeling0.63959989
128MP0008469_abnormal_protein_level0.63633076
129MP0001845_abnormal_inflammatory_respons0.62703440
130MP0003436_decreased_susceptibility_to0.62485006
131MP0005584_abnormal_enzyme/coenzyme_acti0.62146089
132MP0000747_muscle_weakness0.62130409
133MP0001764_abnormal_homeostasis0.61590961
134* MP0009642_abnormal_blood_homeostasis0.59696517
135MP0003453_abnormal_keratinocyte_physiol0.58340185
136MP0005376_homeostasis/metabolism_phenot0.54971509
137MP0000678_abnormal_parathyroid_gland0.54423891
138MP0005025_abnormal_response_to0.54259626
139MP0000467_abnormal_esophagus_morphology0.53750836
140MP0005334_abnormal_fat_pad0.53378532
141MP0009785_altered_susceptibility_to0.53365143
142MP0002452_abnormal_antigen_presenting0.51379549
143MP0000579_abnormal_nail_morphology0.51330917
144* MP0002136_abnormal_kidney_physiology0.51222610
145MP0003656_abnormal_erythrocyte_physiolo0.50868206
146MP0000249_abnormal_blood_vessel0.50476145
147MP0003075_altered_response_to0.48805642
148MP0002078_abnormal_glucose_homeostasis0.48752966
149MP0005165_increased_susceptibility_to0.47401624
150MP0003868_abnormal_feces_composition0.47270194
151MP0006082_CNS_inflammation0.47053819
152MP0002971_abnormal_brown_adipose0.46575897
153MP0005174_abnormal_tail_pigmentation0.45725267
154MP0000427_abnormal_hair_cycle0.44992087
155MP0002653_abnormal_ependyma_morphology0.44490930
156MP0003828_pulmonary_edema0.43814363
157MP0001819_abnormal_immune_cell0.43237140
158MP0009765_abnormal_xenobiotic_induced0.42346913
159MP0000230_abnormal_systemic_arterial0.40734978
160MP0002420_abnormal_adaptive_immunity0.40494835

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.33155328
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.81896705
3Deep venous thrombosis (HP:0002625)6.72118074
4Hypobetalipoproteinemia (HP:0003563)6.29628338
5Acanthocytosis (HP:0001927)6.27041247
6Ileus (HP:0002595)6.18462230
7Abnormality of proline metabolism (HP:0010907)5.87631029
8Hydroxyprolinuria (HP:0003080)5.87631029
9Malnutrition (HP:0004395)5.37578143
10Mesangial abnormality (HP:0001966)4.87753150
11Pigmentary retinal degeneration (HP:0001146)4.79733044
12Hyperglycinuria (HP:0003108)4.58534153
13Cupped ribs (HP:0000887)4.50785534
14Autoimmune hemolytic anemia (HP:0001890)4.31728450
15Hypolipoproteinemia (HP:0010981)4.01178335
16Abnormality of B cell number (HP:0010975)3.98327740
17B lymphocytopenia (HP:0010976)3.98327740
18Conjugated hyperbilirubinemia (HP:0002908)3.97845824
19Right ventricular cardiomyopathy (HP:0011663)3.88700340
20Fat malabsorption (HP:0002630)3.78523387
21Severe combined immunodeficiency (HP:0004430)3.77293122
22Joint hemorrhage (HP:0005261)3.76131032
23Poikilocytosis (HP:0004447)3.73940075
24Chronic diarrhea (HP:0002028)3.69414804
25Increased IgE level (HP:0003212)3.68180435
26Hemorrhage of the eye (HP:0011885)3.64859927
27Prolonged partial thromboplastin time (HP:0003645)3.61619421
28Hypoproteinemia (HP:0003075)3.61316718
29Combined immunodeficiency (HP:0005387)3.59272903
30Thyroiditis (HP:0100646)3.37098519
31Abnormality of serine family amino acid metabolism (HP:0010894)3.17817857
32Abnormality of glycine metabolism (HP:0010895)3.17817857
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.10895471
34Protrusio acetabuli (HP:0003179)3.10308656
35Hypercholesterolemia (HP:0003124)3.09882254
36Abnormality of carpal bone ossification (HP:0006257)3.06932831
37Abnormality of the vitamin B12 metabolism (HP:0004341)3.06446858
38Abdominal distention (HP:0003270)3.05216891
39Xanthomatosis (HP:0000991)3.03874181
40Widely patent fontanelles and sutures (HP:0004492)3.03307327
41Abnormality of the common coagulation pathway (HP:0010990)2.93937885
42Small epiphyses (HP:0010585)2.92817391
43Premature rupture of membranes (HP:0001788)2.91786833
44Potter facies (HP:0002009)2.82996291
45Facial shape deformation (HP:0011334)2.82996291
46Cerebral aneurysm (HP:0004944)2.82356232
47Abnormality of vitamin B metabolism (HP:0004340)2.79895696
48Abnormal glucose tolerance (HP:0001952)2.76731236
49Reticulocytosis (HP:0001923)2.75818440
50Menorrhagia (HP:0000132)2.73496569
51Systemic lupus erythematosus (HP:0002725)2.70805266
52Abnormality of urine glucose concentration (HP:0011016)2.64587011
53Glycosuria (HP:0003076)2.64587011
54Abnormal ossification of hand bones (HP:0005921)2.63685532
55Increased mean platelet volume (HP:0011877)2.61880112
56Complement deficiency (HP:0004431)2.61796584
57Broad palm (HP:0001169)2.60775498
58Ulnar bowing (HP:0003031)2.55753289
59Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53474828
60Myocardial infarction (HP:0001658)2.53381211
61Vertebral compression fractures (HP:0002953)2.51078466
62Abnormality of sulfur amino acid metabolism (HP:0004339)2.51024388
63Hypoplasia of the capital femoral epiphysis (HP:0003090)2.50074581
64Abnormality of complement system (HP:0005339)2.49294175
65Abnormality of purine metabolism (HP:0004352)2.47782407
66Gingivitis (HP:0000230)2.44522063
67Polycythemia (HP:0001901)2.43951517
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.41766281
69Dehydration (HP:0001944)2.41375371
70Abnormal tarsal ossification (HP:0008369)2.40522760
71Pustule (HP:0200039)2.40339840
72Cervical subluxation (HP:0003308)2.37323884
73Abnormal platelet volume (HP:0011876)2.37019358
74Abnormality of the lumbar spine (HP:0100712)2.36074637
75Glomerulonephritis (HP:0000099)2.36057620
76Eosinophilia (HP:0001880)2.34396724
77Broad alveolar ridges (HP:0000187)2.34061536
78Abnormality of the acetabulum (HP:0003170)2.33632257
79Gastrointestinal dysmotility (HP:0002579)2.33602803
80Confusion (HP:0001289)2.32529314
81Epidermoid cyst (HP:0200040)2.32223065
82Nausea (HP:0002018)2.31009549
83Biconcave vertebral bodies (HP:0004586)2.30113854
84Syncope (HP:0001279)2.29067844
85Asymmetry of the thorax (HP:0001555)2.27002840
86Abnormal hand bone ossification (HP:0010660)2.23073013
87Abnormality of eosinophils (HP:0001879)2.22299248
88Abnormality of the Achilles tendon (HP:0005109)2.21732145
89Cheilitis (HP:0100825)2.20648705
90Absent epiphyses (HP:0010577)2.17912643
91Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.17912643
92Megaloblastic anemia (HP:0001889)2.17519721
93Renal duplication (HP:0000075)2.16866216
94Nephrolithiasis (HP:0000787)2.15736068
95Recurrent viral infections (HP:0004429)2.13118548
96Epiphyseal dysplasia (HP:0002656)2.12636369
97Vaginal fistula (HP:0004320)2.11029130
98Metabolic acidosis (HP:0001942)2.10313505
99Disproportionate tall stature (HP:0001519)2.09943728
100Recurrent fungal infections (HP:0002841)2.08805566
101Abnormality of vitamin metabolism (HP:0100508)2.08264275
102Palpitations (HP:0001962)2.07499892
103Abnormality of pyrimidine metabolism (HP:0004353)2.07308082
104Nonimmune hydrops fetalis (HP:0001790)2.06010699
105Abnormal foot bone ossification (HP:0010675)2.05327306
106Neonatal death (HP:0003811)2.02767101
107Vascular calcification (HP:0004934)2.01569963
108Hyperammonemia (HP:0001987)2.00303291
109Purpura (HP:0000979)1.98835899
110Flat acetabular roof (HP:0003180)1.98774667
111Irregular epiphyses (HP:0010582)1.98674942
112Limited elbow extension (HP:0001377)1.98040533
113Granulocytopenia (HP:0001913)1.95305542
114Abnormal albumin level (HP:0012116)1.93099297
115Hypoalbuminemia (HP:0003073)1.93099297
116Mildly elevated creatine phosphokinase (HP:0008180)1.91746450
117Abnormality of the gastric mucosa (HP:0004295)1.89189354
118Eczematoid dermatitis (HP:0000976)1.88953891
119Abnormality of nucleobase metabolism (HP:0010932)1.87714310
120Skin nodule (HP:0200036)1.86067496
121Coxa vara (HP:0002812)1.85485934
122Wide nose (HP:0000445)1.83494084
123Abnormality of small intestinal villus morphology (HP:0011472)1.83223473
124Villous atrophy (HP:0011473)1.83223473
125Cardiovascular calcification (HP:0011915)1.82997760
126Rectal prolapse (HP:0002035)1.82511647
127Vacuolated lymphocytes (HP:0001922)1.82478900
128Blue sclerae (HP:0000592)1.81961816
129Congenital sensorineural hearing impairment (HP:0008527)1.81554184
130Pancreatitis (HP:0001733)1.80583085
131Dysostosis multiplex (HP:0000943)1.80549156
132Progressive sensorineural hearing impairment (HP:0000408)1.80417193
133Impaired platelet aggregation (HP:0003540)1.79216588
134Abnormal platelet function (HP:0011869)1.79216588
135Hepatocellular carcinoma (HP:0001402)1.78150821
136Bundle branch block (HP:0011710)1.77741356
137Fatigue (HP:0012378)1.77347021
138Enlarged kidneys (HP:0000105)1.76283017
139Thin bony cortex (HP:0002753)1.75916000
140Wide cranial sutures (HP:0010537)1.75613921
141Peripheral demyelination (HP:0011096)1.75380245
142Shallow orbits (HP:0000586)1.75374548
143Hyperacusis (HP:0010780)1.74798631
144Flared iliac wings (HP:0002869)1.74621970
145Mucopolysacchariduria (HP:0008155)1.74146303
146Urinary glycosaminoglycan excretion (HP:0003541)1.74146303
147Abnormal delivery (HP:0001787)1.73965586
148Reduced antithrombin III activity (HP:0001976)1.73608952
149Abnormal vertebral ossification (HP:0100569)1.73563084
150Dislocated radial head (HP:0003083)1.72318950
151Mitral stenosis (HP:0001718)1.70408441
152Gingival bleeding (HP:0000225)1.70310325
153Abnormality of the thoracic spine (HP:0100711)1.70230941
154Abnormal gallbladder physiology (HP:0012438)1.69269637
155Cholecystitis (HP:0001082)1.69269637
156Amyloidosis (HP:0011034)1.69060052
157Advanced eruption of teeth (HP:0006288)1.68032055
158Sensorimotor neuropathy (HP:0007141)1.67581499
159Myopathic facies (HP:0002058)1.67264300
160Abnormality of polysaccharide metabolism (HP:0011012)1.67155499
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67155499
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67155499
163Long palpebral fissure (HP:0000637)1.67057693
164Achilles tendon contracture (HP:0001771)1.66466263
165Hypoalphalipoproteinemia (HP:0003233)1.66278526
166Colitis (HP:0002583)1.65542377
167Abnormality of reticulocytes (HP:0004312)1.65427431
168Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64974065
169Vitreoretinal degeneration (HP:0000655)1.64449218
170Aneurysm (HP:0002617)1.63913223
171Diastasis recti (HP:0001540)1.62027321
172Hepatoblastoma (HP:0002884)1.61731005
173Metaphyseal cupping (HP:0003021)1.61074798
174Premature skin wrinkling (HP:0100678)1.60650863
17511 pairs of ribs (HP:0000878)1.58870440
176Heterotopia (HP:0002282)1.58857790
177Protuberant abdomen (HP:0001538)1.57064395
178J-shaped sella turcica (HP:0002680)1.55856082
179Broad face (HP:0000283)1.54985746
180Delayed epiphyseal ossification (HP:0002663)1.54716170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.84503148
2FGFR44.61172302
3LMTK24.37216024
4MST44.30489806
5PRPF4B3.53708987
6SMG13.35692634
7MST1R3.17466677
8GRK63.15975744
9NME13.14176712
10ERN12.76918765
11PRKG22.59933860
12MAP3K102.44200902
13AKT32.40476996
14PTK62.22412644
15SIK12.17236446
16PDGFRA2.15960868
17RIPK12.10662721
18TYRO32.00848169
19FGFR31.99438076
20CDK121.85859341
21MAP2K31.79633640
22MAP2K21.76993733
23RIPK41.72802485
24STK101.70317658
25MAP4K11.60051197
26TAOK31.56712558
27NUAK11.52047428
28TYK21.49907405
29IRAK31.48280804
30SCYL21.45127486
31LATS11.44946887
32WNK41.37955461
33STK241.36780174
34KSR21.31174075
35NME21.28300855
36CDC42BPA1.23617900
37MAP3K71.22785868
38CDK71.21938134
39EPHA21.20471760
40PAK41.19959780
41MAP3K61.19104945
42BMX1.18453426
43TAOK11.15394141
44PKN21.11431087
45MET1.11193858
46MTOR1.09761374
47MAP3K131.09400591
48TRIB31.08950262
49FGFR11.05962668
50TBK11.05768583
51NEK21.04260390
52EPHB11.03867235
53MAP3K21.02291130
54MUSK0.99781003
55TESK20.94574552
56CAMK1D0.94554282
57PRKAA20.93115212
58PBK0.92835235
59MAPK110.89954817
60PDK20.87663031
61BRD40.86369647
62FGFR20.86247272
63CDK90.84987970
64MAP3K80.83981156
65STK30.83683558
66TTK0.83629007
67MAP3K30.79972429
68MAP3K140.77633932
69FLT30.77396383
70SIK20.75792262
71BRSK10.75399698
72TAOK20.74119852
73WNK10.73452326
74ZAP700.73435165
75CDK40.70503932
76BRAF0.70210534
77EEF2K0.68348089
78PRKAA10.67149854
79DYRK1B0.64250707
80ERBB40.63743459
81NTRK10.63355094
82MAP3K110.61155166
83EPHB20.60859477
84LATS20.60707584
85EIF2AK10.59546103
86RET0.59100236
87MAP3K10.58677010
88TGFBR20.57277065
89FGR0.57085555
90MARK20.55081659
91PDPK10.54445442
92CDK80.53968256
93CHEK10.53961076
94PIK3CG0.53611458
95MATK0.53570547
96CSK0.53156553
97MAP3K90.52961280
98STK38L0.52926490
99YES10.52924549
100JAK10.51513346
101NEK10.49923251
102TTN0.49889539
103CDK60.49119818
104IRAK20.45121932
105PDGFRB0.44256599
106PRKCQ0.42774497
107PTK20.42492838
108MAP2K60.42412542
109MELK0.40456266
110PHKG20.40451314
111PHKG10.40451314
112DMPK0.39884073
113ITK0.38475267
114PDK10.37887398
115IKBKE0.37291264
116NEK90.37248703
117PRKD20.36509132
118JAK20.35346548
119TNIK0.34801311
120CAMK1G0.34492213
121CHEK20.33564917
122PIM10.32130165
123VRK20.31911236
124PAK20.31904620
125KIT0.31754887
126MAP2K10.31453967
127RPS6KB20.31091229
128DDR20.30124822
129RPS6KA20.29961899
130ARAF0.28906405
131ROCK10.28779010
132JAK30.28546365
133STK40.28501773
134AKT20.27987912
135PRKCD0.26860881
136PRKCI0.26535227
137PIM20.24307430
138ABL10.23346474
139MAPKAPK20.22882170
140IRAK40.22608594
141PRKCA0.22481076
142SGK30.22436480
143MAPK120.22349784
144ICK0.21256375
145SRC0.19665286
146PAK30.19156889
147ERBB20.18465242
148MYLK0.18151830

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.18138464
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.01748201
3Renin-angiotensin system_Homo sapiens_hsa046144.32265317
4Vitamin digestion and absorption_Homo sapiens_hsa049774.11600443
5* Mineral absorption_Homo sapiens_hsa049783.36920287
6Complement and coagulation cascades_Homo sapiens_hsa046103.33563345
7Caffeine metabolism_Homo sapiens_hsa002323.16141229
8Galactose metabolism_Homo sapiens_hsa000523.03096622
9Starch and sucrose metabolism_Homo sapiens_hsa005002.86323486
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.85176110
11Folate biosynthesis_Homo sapiens_hsa007902.78609553
12Protein digestion and absorption_Homo sapiens_hsa049742.42520058
13Fructose and mannose metabolism_Homo sapiens_hsa000512.19927894
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.99892172
15Bile secretion_Homo sapiens_hsa049761.95064126
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85571711
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72855058
18Glycerolipid metabolism_Homo sapiens_hsa005611.67312107
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.55444757
20Sulfur metabolism_Homo sapiens_hsa009201.53642179
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52089927
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42688659
23Histidine metabolism_Homo sapiens_hsa003401.39635727
24PPAR signaling pathway_Homo sapiens_hsa033201.39625146
25Sphingolipid metabolism_Homo sapiens_hsa006001.33555167
26Fatty acid degradation_Homo sapiens_hsa000711.31764874
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30721788
28N-Glycan biosynthesis_Homo sapiens_hsa005101.30599907
29Arginine and proline metabolism_Homo sapiens_hsa003301.20001374
30ABC transporters_Homo sapiens_hsa020101.14655503
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13266866
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11938620
33DNA replication_Homo sapiens_hsa030301.09669962
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08729799
35Notch signaling pathway_Homo sapiens_hsa043301.07098508
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06066875
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04513742
38Prion diseases_Homo sapiens_hsa050201.03686946
39Glutathione metabolism_Homo sapiens_hsa004801.02887003
40Tryptophan metabolism_Homo sapiens_hsa003801.01766063
41Arginine biosynthesis_Homo sapiens_hsa002200.98992417
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97015890
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95622431
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95612391
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95580891
46Pancreatic secretion_Homo sapiens_hsa049720.95411191
47Fatty acid biosynthesis_Homo sapiens_hsa000610.95051582
48Chronic myeloid leukemia_Homo sapiens_hsa052200.94702673
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.92681648
50Sulfur relay system_Homo sapiens_hsa041220.91588344
51ECM-receptor interaction_Homo sapiens_hsa045120.91210367
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91011698
53Staphylococcus aureus infection_Homo sapiens_hsa051500.90194288
54Thyroid cancer_Homo sapiens_hsa052160.89763083
55Small cell lung cancer_Homo sapiens_hsa052220.88789126
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87795775
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87037029
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86715817
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82826959
60One carbon pool by folate_Homo sapiens_hsa006700.81155673
61Non-small cell lung cancer_Homo sapiens_hsa052230.78935172
62Carbon metabolism_Homo sapiens_hsa012000.78272084
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.76939393
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75527014
65Acute myeloid leukemia_Homo sapiens_hsa052210.75469085
66Nitrogen metabolism_Homo sapiens_hsa009100.75177105
67Phenylalanine metabolism_Homo sapiens_hsa003600.75013564
68VEGF signaling pathway_Homo sapiens_hsa043700.74476222
69Pentose phosphate pathway_Homo sapiens_hsa000300.73280459
70Insulin signaling pathway_Homo sapiens_hsa049100.71182723
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69717586
72Base excision repair_Homo sapiens_hsa034100.69057358
73Adherens junction_Homo sapiens_hsa045200.67394807
74Proteoglycans in cancer_Homo sapiens_hsa052050.67354759
75mRNA surveillance pathway_Homo sapiens_hsa030150.64422979
76HIF-1 signaling pathway_Homo sapiens_hsa040660.64346205
77Fatty acid metabolism_Homo sapiens_hsa012120.63585618
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.63327230
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61757249
80beta-Alanine metabolism_Homo sapiens_hsa004100.60898365
81Focal adhesion_Homo sapiens_hsa045100.59368366
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.54230832
83MicroRNAs in cancer_Homo sapiens_hsa052060.54150190
84Pancreatic cancer_Homo sapiens_hsa052120.53116124
85Pyruvate metabolism_Homo sapiens_hsa006200.52999201
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50355226
87Cell cycle_Homo sapiens_hsa041100.49987724
88Glucagon signaling pathway_Homo sapiens_hsa049220.49705359
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49326567
90Biosynthesis of amino acids_Homo sapiens_hsa012300.49191806
91Steroid biosynthesis_Homo sapiens_hsa001000.49133536
92Other glycan degradation_Homo sapiens_hsa005110.49105677
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48028464
94Amoebiasis_Homo sapiens_hsa051460.47497189
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47391644
96Vitamin B6 metabolism_Homo sapiens_hsa007500.47291463
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.45705457
98Endometrial cancer_Homo sapiens_hsa052130.45047704
99Type II diabetes mellitus_Homo sapiens_hsa049300.44738148
100African trypanosomiasis_Homo sapiens_hsa051430.43916122
101Peroxisome_Homo sapiens_hsa041460.43901369
102AMPK signaling pathway_Homo sapiens_hsa041520.42837892
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42666853
104Lysine degradation_Homo sapiens_hsa003100.41472984
105Propanoate metabolism_Homo sapiens_hsa006400.40672734
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40001208
107Mismatch repair_Homo sapiens_hsa034300.38738618
108Viral carcinogenesis_Homo sapiens_hsa052030.36551403
109Ether lipid metabolism_Homo sapiens_hsa005650.35860865
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35791965
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34034909
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33566388
113Thyroid hormone synthesis_Homo sapiens_hsa049180.32016210
114Arachidonic acid metabolism_Homo sapiens_hsa005900.31925386
115Linoleic acid metabolism_Homo sapiens_hsa005910.31636857
116Salmonella infection_Homo sapiens_hsa051320.30288269
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30011392
118Influenza A_Homo sapiens_hsa051640.29907863
119Retinol metabolism_Homo sapiens_hsa008300.29779323
120Legionellosis_Homo sapiens_hsa051340.28375385
121Apoptosis_Homo sapiens_hsa042100.27266526
122Metabolic pathways_Homo sapiens_hsa011000.25790012
123Tuberculosis_Homo sapiens_hsa051520.25787603
124Hepatitis C_Homo sapiens_hsa051600.25394640
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24689359
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24075343
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.23445066
128Chemical carcinogenesis_Homo sapiens_hsa052040.21297345
129Insulin resistance_Homo sapiens_hsa049310.19840229
130Inositol phosphate metabolism_Homo sapiens_hsa005620.18219008
131Selenocompound metabolism_Homo sapiens_hsa004500.17946810
132Hematopoietic cell lineage_Homo sapiens_hsa046400.16064192
133Leishmaniasis_Homo sapiens_hsa051400.15129873
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.14775959
135Tight junction_Homo sapiens_hsa045300.13716701
136Primary immunodeficiency_Homo sapiens_hsa053400.11683702
137Bladder cancer_Homo sapiens_hsa052190.11572515
138Lysosome_Homo sapiens_hsa041420.10669107
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10030814
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09599801
141Gastric acid secretion_Homo sapiens_hsa049710.08145066
142Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.07972050
143Toll-like receptor signaling pathway_Homo sapiens_hsa046200.07549009
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06754755
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.06498214
146Toxoplasmosis_Homo sapiens_hsa051450.06323134
147TNF signaling pathway_Homo sapiens_hsa046680.05020313
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.04199136
149Choline metabolism in cancer_Homo sapiens_hsa052310.03341546
150Pertussis_Homo sapiens_hsa051330.03043751

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