SLC26A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1xenobiotic catabolic process (GO:0042178)9.22087358
2response to nitrosative stress (GO:0051409)9.21492019
3regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)8.44118089
4regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033396.86845569
5nephron tubule formation (GO:0072079)6.65704801
6response to parathyroid hormone (GO:0071107)6.39229378
7regulation of skeletal muscle contraction (GO:0014819)6.16564165
8metanephric tubule development (GO:0072170)6.13082672
9metanephric nephron tubule development (GO:0072234)6.13082672
10thyroid gland development (GO:0030878)6.12193813
11negative regulation of metanephros development (GO:0072217)6.08399225
12atrioventricular valve morphogenesis (GO:0003181)5.85025563
13pattern specification involved in kidney development (GO:0061004)5.69257564
14positive regulation of osteoblast proliferation (GO:0033690)5.68979475
15regulation of apoptotic process involved in morphogenesis (GO:1902337)5.68813252
16relaxation of cardiac muscle (GO:0055119)5.63165140
17metanephric nephron epithelium development (GO:0072243)5.59587954
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.51816062
19regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.49891093
20metanephric epithelium development (GO:0072207)5.16683705
21* sulfate transmembrane transport (GO:1902358)5.07786940
22positive regulation of hormone metabolic process (GO:0032352)5.05420722
23regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.92696866
24positive regulation of male gonad development (GO:2000020)4.76933724
25response to lead ion (GO:0010288)4.76706349
26skin morphogenesis (GO:0043589)4.76307834
27hormone biosynthetic process (GO:0042446)4.75873104
28negative regulation of microtubule polymerization (GO:0031115)4.66793410
29mesonephros development (GO:0001823)4.66791362
30regulation of male gonad development (GO:2000018)4.63805906
31urogenital system development (GO:0001655)4.61947177
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.53358462
33regulation of myelination (GO:0031641)4.52300099
34regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.47093577
35pericardium development (GO:0060039)4.32596341
36positive regulation of glycogen biosynthetic process (GO:0045725)4.22246517
37hydrogen peroxide catabolic process (GO:0042744)4.21566997
38regulation of mesenchymal cell apoptotic process (GO:2001053)4.17979302
39positive regulation of metanephros development (GO:0072216)4.12990777
40* sulfate transport (GO:0008272)4.11729766
41regulation of hormone metabolic process (GO:0032350)4.08610517
42regulation of stem cell maintenance (GO:2000036)3.99310363
43glucuronate metabolic process (GO:0019585)3.98872141
44uronic acid metabolic process (GO:0006063)3.98872141
45endothelial cell chemotaxis (GO:0035767)3.98391797
46gonadal mesoderm development (GO:0007506)3.95843618
47surfactant homeostasis (GO:0043129)3.92905924
48relaxation of muscle (GO:0090075)3.91016991
49glutathione derivative metabolic process (GO:1901685)3.89750886
50glutathione derivative biosynthetic process (GO:1901687)3.89750886
51cellular glucuronidation (GO:0052695)3.85147618
52regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.83497196
53positive regulation of cellular amine metabolic process (GO:0033240)3.83148988
54androgen biosynthetic process (GO:0006702)3.74403614
55mesenchymal to epithelial transition (GO:0060231)3.73888546
56response to vitamin D (GO:0033280)3.73871898
57cell migration involved in sprouting angiogenesis (GO:0002042)3.73417086
58regulation of extracellular matrix disassembly (GO:0010715)3.72375057
59specification of organ identity (GO:0010092)3.67651078
60benzene-containing compound metabolic process (GO:0042537)3.61219655
61nephron tubule development (GO:0072080)3.60274763
62positive regulation of p38MAPK cascade (GO:1900745)3.57664570
63branching involved in salivary gland morphogenesis (GO:0060445)3.55205389
64positive regulation of glycogen metabolic process (GO:0070875)3.54631667
65interleukin-6-mediated signaling pathway (GO:0070102)3.49996753
66phenol-containing compound metabolic process (GO:0018958)3.49744517
67sex determination (GO:0007530)3.46469401
68response to caffeine (GO:0031000)3.46085126
69negative regulation of kidney development (GO:0090185)3.46023791
70phosphorelay signal transduction system (GO:0000160)3.41683868
71positive regulation of astrocyte differentiation (GO:0048711)3.40438806
72cell proliferation involved in kidney development (GO:0072111)3.37742070
73cellular potassium ion homeostasis (GO:0030007)3.34609118
74hemidesmosome assembly (GO:0031581)3.33026017
75primitive streak formation (GO:0090009)3.32871289
76regulation of osteoblast proliferation (GO:0033688)3.30887670
77renal tubule development (GO:0061326)3.30504355
78outer ear morphogenesis (GO:0042473)3.26486585
79positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.20959244
80cardiovascular system development (GO:0072358)3.19389051
81cellular response to gonadotropin stimulus (GO:0071371)3.18572196
82regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.15515592
83iron ion import (GO:0097286)3.13388721
84chemical homeostasis within a tissue (GO:0048875)3.08644302
85regulation of metanephros development (GO:0072215)3.07871587
86Leydig cell differentiation (GO:0033327)3.05825671
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.02739911
88vitamin A metabolic process (GO:0006776)3.02291362
89negative regulation of chondrocyte differentiation (GO:0032331)3.02249461
90angiogenesis involved in wound healing (GO:0060055)3.01649887
91mesenchymal cell proliferation (GO:0010463)2.98902848
92renal absorption (GO:0070293)2.98478352
93oocyte development (GO:0048599)2.95324520
94epithelial cell-cell adhesion (GO:0090136)2.94818117
95negative regulation of fatty acid transport (GO:2000192)2.93760076
96metanephric mesenchyme development (GO:0072075)2.91502472
97negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.88579732
98nephron epithelium development (GO:0072009)2.88225804
99branching involved in ureteric bud morphogenesis (GO:0001658)2.85137384
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.84251491
101regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.82285720
102regulation of steroid hormone biosynthetic process (GO:0090030)2.81432390
103positive regulation of odontogenesis (GO:0042482)2.80406114
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.76970818
105regulation of p38MAPK cascade (GO:1900744)2.76952710
106response to dietary excess (GO:0002021)2.76793688
107positive regulation of mesonephros development (GO:0061213)2.76518532
108bone remodeling (GO:0046849)2.74981875
109positive regulation of extracellular matrix organization (GO:1903055)2.70288980
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.70255570
111axon extension involved in axon guidance (GO:0048846)2.70255570
112SMAD protein signal transduction (GO:0060395)2.70160430
113heart valve morphogenesis (GO:0003179)2.69380960
114hormone metabolic process (GO:0042445)2.68041749
115cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.67311381
116male sex determination (GO:0030238)2.66815081
117hormone catabolic process (GO:0042447)2.66797399
118glutathione metabolic process (GO:0006749)2.66490374
119endocardial cushion morphogenesis (GO:0003203)2.66363898
120dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.66141144
121cerebral cortex neuron differentiation (GO:0021895)2.66034378
122regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.64325417
123negative regulation of hormone biosynthetic process (GO:0032353)2.64193189
124negative regulation of hormone metabolic process (GO:0032351)2.64193189
125mesenchyme morphogenesis (GO:0072132)2.63036486
126kidney mesenchyme development (GO:0072074)2.61939759
127sex differentiation (GO:0007548)2.60395603
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.59573330
129regulation of glucocorticoid metabolic process (GO:0031943)2.58225901
130regulation of cardioblast proliferation (GO:0003264)2.57775298
131regulation of secondary heart field cardioblast proliferation (GO:0003266)2.57775298
132one-carbon compound transport (GO:0019755)2.57492448
133positive regulation of digestive system process (GO:0060456)2.56885428
134regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.56271784
135regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.55491496
136estrogen metabolic process (GO:0008210)2.54816582
137generation of neurons (GO:0048699)2.54695739
138glomerular basement membrane development (GO:0032836)2.54580640
139endothelial cell morphogenesis (GO:0001886)2.54325310
140mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52305940
141response to gonadotropin (GO:0034698)2.49834318
142regulation of glomerular filtration (GO:0003093)2.49697146
143bone resorption (GO:0045453)2.49321419
144positive regulation of hormone biosynthetic process (GO:0046886)2.48239906
145phosphatidylinositol dephosphorylation (GO:0046856)2.47651356
146hydrogen peroxide metabolic process (GO:0042743)2.47533662
147atrial cardiac muscle cell action potential (GO:0086014)2.47247326
148positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.47129588
149regulation of water loss via skin (GO:0033561)2.46659240
150regulation of G0 to G1 transition (GO:0070316)2.45645695
151L-ascorbic acid metabolic process (GO:0019852)2.45112426
152regulation of axon extension involved in axon guidance (GO:0048841)2.43954596
153membrane repolarization during action potential (GO:0086011)2.43546597
154blood vessel endothelial cell migration (GO:0043534)2.43546487
155phospholipid dephosphorylation (GO:0046839)2.43537843
156regulation of hormone biosynthetic process (GO:0046885)2.43247569
157positive regulation of actin filament depolymerization (GO:0030836)2.43088978
158response to epinephrine (GO:0071871)2.42765467
159regulation of extracellular matrix organization (GO:1903053)2.39764364
160embryonic hemopoiesis (GO:0035162)2.38905071
161glomerulus development (GO:0032835)2.38518416
162pathway-restricted SMAD protein phosphorylation (GO:0060389)2.37786821
163hair follicle morphogenesis (GO:0031069)2.36495599
164G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34294946
165negative regulation of stem cell differentiation (GO:2000737)2.32950684
166positive regulation of cartilage development (GO:0061036)2.32189183
167positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.31311510
168regulation of transcription involved in cell fate commitment (GO:0060850)2.31290262
169regulation of mesonephros development (GO:0061217)2.29216555
170negative regulation of cardiac muscle tissue development (GO:0055026)2.28712986
171carnitine metabolic process (GO:0009437)2.27977290
172cellular response to epinephrine stimulus (GO:0071872)2.26858178
173facial nerve structural organization (GO:0021612)2.25784821
174thyroid hormone generation (GO:0006590)18.6987279
175thyroid hormone metabolic process (GO:0042403)15.3416061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38602176
2CLOCK_20551151_ChIP-Seq_293T_Human2.95481540
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90426762
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.77479531
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.57510867
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47768436
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.44603894
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.31519552
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31422159
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.19975138
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14358975
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09476798
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03255328
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.98299497
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97443778
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89846568
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89846568
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89846568
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.80308406
20* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78947908
21FUS_26573619_Chip-Seq_HEK293_Human1.71342368
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71230376
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69241516
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68744567
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.65362396
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60533539
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60533539
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.60113766
29ZNF263_19887448_ChIP-Seq_K562_Human1.59777040
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.58522347
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.58522347
32TP53_16413492_ChIP-PET_HCT116_Human1.57872156
33SMAD3_21741376_ChIP-Seq_HESCs_Human1.55548192
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54238181
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52771476
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.52677455
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.51767472
38CJUN_26792858_Chip-Seq_BT549_Human1.51018634
39AHR_22903824_ChIP-Seq_MCF-7_Human1.50590807
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49538393
41* KLF5_25053715_ChIP-Seq_YYC3_Human1.49417486
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.48475702
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47229698
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46609464
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46483779
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46011628
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45285918
48PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44131084
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43050908
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42791525
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.41924400
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41479325
53DROSHA_22980978_ChIP-Seq_HELA_Human1.41345348
54NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41204818
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40537856
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.39908741
57TBX3_20139965_ChIP-Seq_MESCs_Mouse1.39823390
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.39755542
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.39643329
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39591492
61SOX2_20726797_ChIP-Seq_SW620_Human1.37657657
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37624146
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.37218149
64SMAD4_21799915_ChIP-Seq_A2780_Human1.36220112
65TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36175410
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.34079568
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.34079568
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.33847174
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33578013
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31049854
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.28656908
72* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27446180
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27131571
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.25995035
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25503750
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.24836852
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24696690
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22388360
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22116572
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21402273
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.21266307
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20376196
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20327362
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19722196
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18704032
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17646042
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17473382
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17473382
89* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16608143
90JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16399600
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16213226
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16155674
93SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15996459
94RUNX1_27514584_Chip-Seq_MCF-7_Human1.15554355
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14812163
96* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13698667
97SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13444777
98RNF2_27304074_Chip-Seq_NSC_Mouse1.13171586
99RXR_22108803_ChIP-Seq_LS180_Human1.12319411
100AR_21572438_ChIP-Seq_LNCaP_Human1.11958662
101* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11887098
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11404103
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.11308535
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11299723
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09743053
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09392750
107RING1B_27294783_Chip-Seq_ESCs_Mouse1.08111040
108* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05252638
109TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04909669
110TP53_18474530_ChIP-ChIP_U2OS_Human1.04870927
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04077331
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03485238
113ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03023778
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02385398
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.02378830
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01486983
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.00896387
118SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00526682
119EZH2_27294783_Chip-Seq_ESCs_Mouse1.00120698
120* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99812710
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99663506
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99600750
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99493173
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.99238495
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97940221
126SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97255084
127KDM2B_26808549_Chip-Seq_K562_Human0.97032494
128JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96752096
129TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96482360
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96447740
131EZH2_27304074_Chip-Seq_ESCs_Mouse0.96308032
132ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95568598
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95542705
134* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94492648
135* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94454531
136BCAT_22108803_ChIP-Seq_LS180_Human0.94242553
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94196914
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93814682
139FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93759422
140RACK7_27058665_Chip-Seq_MCF-7_Human0.93041094
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91837403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland5.68654219
2MP0000681_abnormal_thyroid_gland5.63316499
3MP0000383_abnormal_hair_follicle4.39320881
4MP0008995_early_reproductive_senescence3.67007558
5MP0010678_abnormal_skin_adnexa3.61196461
6MP0008004_abnormal_stomach_pH3.36177859
7MP0010030_abnormal_orbit_morphology3.30939829
8MP0004742_abnormal_vestibular_system2.88634892
9MP0001485_abnormal_pinna_reflex2.83524752
10MP0008789_abnormal_olfactory_epithelium2.77344697
11MP0008438_abnormal_cutaneous_collagen2.75867081
12MP0003878_abnormal_ear_physiology2.60409913
13MP0005377_hearing/vestibular/ear_phenot2.60409913
14MP0003879_abnormal_hair_cell2.53049166
15MP0008875_abnormal_xenobiotic_pharmacok2.40185811
16MP0009250_abnormal_appendicular_skeleto2.36180698
17MP0003890_abnormal_embryonic-extraembry2.33598723
18MP0009053_abnormal_anal_canal2.25662923
19MP0010368_abnormal_lymphatic_system2.21127729
20MP0001346_abnormal_lacrimal_gland2.20361566
21MP0000762_abnormal_tongue_morphology2.14019835
22MP0002877_abnormal_melanocyte_morpholog2.11956576
23MP0005394_taste/olfaction_phenotype2.10145318
24MP0005499_abnormal_olfactory_system2.10145318
25MP0000537_abnormal_urethra_morphology2.01677527
26MP0008569_lethality_at_weaning1.99082084
27MP0000566_synostosis1.89713436
28MP0004272_abnormal_basement_membrane1.87705080
29MP0002233_abnormal_nose_morphology1.82946533
30MP0002234_abnormal_pharynx_morphology1.80241364
31MP0000534_abnormal_ureter_morphology1.78229832
32MP0009780_abnormal_chondrocyte_physiolo1.77346378
33MP0000026_abnormal_inner_ear1.74846579
34MP0001963_abnormal_hearing_physiology1.74669251
35MP0004264_abnormal_extraembryonic_tissu1.74636577
36MP0005408_hypopigmentation1.73477995
37* MP0004043_abnormal_pH_regulation1.72536369
38MP0002896_abnormal_bone_mineralization1.67289350
39MP0003942_abnormal_urinary_system1.59588473
40MP0004134_abnormal_chest_morphology1.57328413
41MP0005508_abnormal_skeleton_morphology1.48954887
42MP0002295_abnormal_pulmonary_circulatio1.48942720
43MP0005187_abnormal_penis_morphology1.43519679
44MP0002098_abnormal_vibrissa_morphology1.43318000
45MP0005275_abnormal_skin_tensile1.40042786
46MP0003195_calcinosis1.39936638
47MP0005171_absent_coat_pigmentation1.39009720
48MP0001765_abnormal_ion_homeostasis1.34206366
49MP0000049_abnormal_middle_ear1.31817345
50MP0003786_premature_aging1.30176025
51MP0010234_abnormal_vibrissa_follicle1.30131144
52MP0009278_abnormal_bone_marrow1.25994915
53MP0003115_abnormal_respiratory_system1.23912351
54MP0003705_abnormal_hypodermis_morpholog1.23031427
55MP0003755_abnormal_palate_morphology1.20532732
56MP0002876_abnormal_thyroid_physiology1.20043989
57MP0003011_delayed_dark_adaptation1.19793498
58MP0009379_abnormal_foot_pigmentation1.18806199
59MP0000372_irregular_coat_pigmentation1.18041468
60MP0000920_abnormal_myelination1.17025334
61MP0002249_abnormal_larynx_morphology1.16703928
62MP0000428_abnormal_craniofacial_morphol1.11833973
63* MP0009643_abnormal_urine_homeostasis1.11791972
64MP0003385_abnormal_body_wall1.11365079
65MP0003690_abnormal_glial_cell1.09664137
66MP0000163_abnormal_cartilage_morphology1.08765029
67MP0001879_abnormal_lymphatic_vessel1.08326909
68MP0003935_abnormal_craniofacial_develop1.07657724
69MP0001958_emphysema1.05860037
70MP0008961_abnormal_basal_metabolism1.04733653
71MP0009384_cardiac_valve_regurgitation1.01709217
72MP0004084_abnormal_cardiac_muscle1.01625279
73MP0000733_abnormal_muscle_development1.01357841
74MP0003941_abnormal_skin_development0.99960148
75MP0002060_abnormal_skin_morphology0.99929372
76MP0002254_reproductive_system_inflammat0.99868609
77MP0003937_abnormal_limbs/digits/tail_de0.99610782
78MP0005647_abnormal_sex_gland0.98892929
79MP0004484_altered_response_of0.95302937
80MP0002116_abnormal_craniofacial_bone0.94854937
81MP0001270_distended_abdomen0.93677272
82MP0005409_darkened_coat_color0.93476233
83MP0001299_abnormal_eye_distance/0.91510235
84MP0003315_abnormal_perineum_morphology0.91114630
85MP0000467_abnormal_esophagus_morphology0.90375498
86MP0005248_abnormal_Harderian_gland0.90055697
87MP0003300_gastrointestinal_ulcer0.89661711
88MP0005503_abnormal_tendon_morphology0.88492070
89MP0003566_abnormal_cell_adhesion0.87951809
90MP0003938_abnormal_ear_development0.86044479
91MP0003868_abnormal_feces_composition0.85640994
92MP0003936_abnormal_reproductive_system0.85082793
93MP0009703_decreased_birth_body0.84592128
94MP0002168_other_aberrant_phenotype0.80623275
95MP0000631_abnormal_neuroendocrine_gland0.77947605
96MP0003279_aneurysm0.77638393
97MP0003959_abnormal_lean_body0.76405823
98* MP0001756_abnormal_urination0.74695996
99MP0008872_abnormal_physiological_respon0.74226143
100MP0002177_abnormal_outer_ear0.74114255
101MP0002090_abnormal_vision0.73555971
102MP0004019_abnormal_vitamin_homeostasis0.73439213
103MP0001849_ear_inflammation0.73231977
104MP0005623_abnormal_meninges_morphology0.73157559
105MP0001919_abnormal_reproductive_system0.73129629
106MP0001177_atelectasis0.72980865
107MP0002638_abnormal_pupillary_reflex0.72422480
108MP0003186_abnormal_redox_activity0.72310749
109MP0001501_abnormal_sleep_pattern0.71555652
110MP0004885_abnormal_endolymph0.71143433
111MP0003953_abnormal_hormone_level0.70638651
112MP0005023_abnormal_wound_healing0.69524176
113MP0006138_congestive_heart_failure0.69385957
114MP0002751_abnormal_autonomic_nervous0.69158880
115MP0002115_abnormal_skeleton_extremities0.68867803
116MP0000613_abnormal_salivary_gland0.68028147
117MP0003183_abnormal_peptide_metabolism0.67999091
118MP0002113_abnormal_skeleton_development0.67755078
119MP0002282_abnormal_trachea_morphology0.65132089
120MP0004883_abnormal_blood_vessel0.64916148
121MP0009672_abnormal_birth_weight0.63794722
122MP0010771_integument_phenotype0.62090925
123MP0000462_abnormal_digestive_system0.61649988
124MP0004185_abnormal_adipocyte_glucose0.61608703
125MP0003119_abnormal_digestive_system0.60606049
126MP0002932_abnormal_joint_morphology0.60045498
127MP0005584_abnormal_enzyme/coenzyme_acti0.59190832
128MP0002928_abnormal_bile_duct0.56455910
129MP0003137_abnormal_impulse_conducting0.56414726
130MP0000003_abnormal_adipose_tissue0.52398644
131MP0001731_abnormal_postnatal_growth0.49270382
132MP0003943_abnormal_hepatobiliary_system0.48814374
133MP0005365_abnormal_bile_salt0.48040675
134MP0005375_adipose_tissue_phenotype0.44554928
135MP0001764_abnormal_homeostasis0.44128432
136MP0005636_abnormal_mineral_homeostasis0.42409664
137MP0003795_abnormal_bone_structure0.39867792
138MP0002229_neurodegeneration0.38930772
139MP0005666_abnormal_adipose_tissue0.38849548
140MP0003221_abnormal_cardiomyocyte_apopto0.38433755
141MP0002009_preneoplasia0.37596334
142MP0003698_abnormal_male_reproductive0.37408353
143MP0005076_abnormal_cell_differentiation0.37309086
144MP0002933_joint_inflammation0.35875632
145* MP0002136_abnormal_kidney_physiology0.35735898
146MP0000767_abnormal_smooth_muscle0.34501381

Predicted human phenotypes

RankGene SetZ-score
1Goiter (HP:0000853)8.97405294
2Hyperthyroidism (HP:0000836)7.95437885
3Congenital sensorineural hearing impairment (HP:0008527)7.73840648
4Pili torti (HP:0003777)7.48184549
5Abnormality of cochlea (HP:0000375)5.70906429
6Hypothermia (HP:0002045)5.67098116
7Thyroid-stimulating hormone excess (HP:0002925)5.28024161
8Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)4.87806433
9Tetany (HP:0001281)4.86911281
10Increased circulating renin level (HP:0000848)4.84552068
11Morphological abnormality of the inner ear (HP:0011390)4.48116683
12Small epiphyses (HP:0010585)4.30452378
13Hyperphosphatemia (HP:0002905)4.26830523
14Onycholysis (HP:0001806)4.18058115
15Abnormal hair laboratory examination (HP:0003328)4.06028738
16Hypokalemic alkalosis (HP:0001949)4.03431291
17Metabolic alkalosis (HP:0200114)3.94938963
18Stomach cancer (HP:0012126)3.58632434
19Bifid scrotum (HP:0000048)3.54883836
20Thyroid carcinoma (HP:0002890)3.50624434
21Abnormality of chloride homeostasis (HP:0011422)3.19554540
22Delayed epiphyseal ossification (HP:0002663)3.11218132
23Abnormal sex determination (HP:0012244)3.07376519
24Sex reversal (HP:0012245)3.07376519
25Bronchomalacia (HP:0002780)3.07163760
26Gonadotropin excess (HP:0000837)3.04648244
27Atrophic scars (HP:0001075)3.01954799
28Abnormality of the middle phalanges of the toes (HP:0010183)2.99817985
29Ulnar claw (HP:0001178)2.95094572
30Broad metatarsal (HP:0001783)2.90538378
31Synostosis involving the elbow (HP:0003938)2.90430849
32Humeroradial synostosis (HP:0003041)2.90430849
33Mild short stature (HP:0003502)2.83518077
34Abnormality of the distal phalanges of the toes (HP:0010182)2.78377767
35Asymmetry of the thorax (HP:0001555)2.77487234
36Hyperparathyroidism (HP:0000843)2.77485064
37Thickened helices (HP:0000391)2.74397801
38Abnormality of renin-angiotensin system (HP:0000847)2.72430603
39Cervical subluxation (HP:0003308)2.71651187
40Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.69590058
41Premature rupture of membranes (HP:0001788)2.69021536
42Lip pit (HP:0100267)2.65234910
43Gonadal dysgenesis (HP:0000133)2.62681818
44Hyperpituitarism (HP:0010514)2.60603350
45Hyperactive renin-angiotensin system (HP:0000841)2.59788365
46Hypothyroidism (HP:0000821)2.59404250
47Abnormality of dentin (HP:0010299)2.59053665
48Aplasia involving bones of the extremities (HP:0009825)2.58251076
49Aplasia involving bones of the upper limbs (HP:0009823)2.58251076
50Aplasia of the phalanges of the hand (HP:0009802)2.58251076
51Irregular epiphyses (HP:0010582)2.53504440
52Bradycardia (HP:0001662)2.50080021
53Down-sloping shoulders (HP:0200021)2.49075558
54Distal lower limb muscle weakness (HP:0009053)2.47668366
55Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.45773277
56Umbilical hernia (HP:0001537)2.43817338
57Prenatal maternal abnormality (HP:0002686)2.42829200
58Male pseudohermaphroditism (HP:0000037)2.42446835
59Tracheal stenosis (HP:0002777)2.42248830
60Abnormal hemoglobin (HP:0011902)2.42019540
61Milia (HP:0001056)2.41034354
62Shallow orbits (HP:0000586)2.39791644
63Hypoparathyroidism (HP:0000829)2.38460558
64Short hallux (HP:0010109)2.35946491
65Ankle contracture (HP:0006466)2.35888299
66Hoarse voice (HP:0001609)2.34621555
67Split foot (HP:0001839)2.31150184
68Scapular winging (HP:0003691)2.27112148
69Fragile nails (HP:0001808)2.25644301
70Protrusio acetabuli (HP:0003179)2.24143928
71Flat acetabular roof (HP:0003180)2.23972949
72Abnormality of the phalanges of the 2nd finger (HP:0009541)2.23463371
73Aplasia/Hypoplasia of the hallux (HP:0008362)2.19866977
74Stridor (HP:0010307)2.19768533
75Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.18470348
76Short middle phalanx of the 5th finger (HP:0004220)2.17887749
77Deviation of the hallux (HP:0010051)2.16866867
78Germ cell neoplasia (HP:0100728)2.15652584
79Coarse facial features (HP:0000280)2.15250285
80Hallux valgus (HP:0001822)2.14305971
81Adrenal overactivity (HP:0002717)2.11394401
82Abnormality of the 2nd finger (HP:0004100)2.10628416
83Right ventricular cardiomyopathy (HP:0011663)2.10165978
84Polyuria (HP:0000103)2.09861367
85Hypokalemia (HP:0002900)2.09375471
86Male infertility (HP:0003251)2.08203782
87Accelerated skeletal maturation (HP:0005616)2.07192657
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03853691
89Epiphyseal dysplasia (HP:0002656)2.02694993
90Urethral obstruction (HP:0000796)2.01054572
91Upper limb muscle weakness (HP:0003484)2.00958920
92Hypomagnesemia (HP:0002917)2.00860087
93Short middle phalanx of finger (HP:0005819)1.99652919
94Mesomelia (HP:0003027)1.99501641
95Renal salt wasting (HP:0000127)1.98901195
96Alkalosis (HP:0001948)1.97281174
97Follicular hyperkeratosis (HP:0007502)1.97261243
98Segmental peripheral demyelination/remyelination (HP:0003481)1.97053599
99Abnormality of the dental root (HP:0006486)1.96967899
100Taurodontia (HP:0000679)1.96967899
101Abnormality of permanent molar morphology (HP:0011071)1.96967899
102Short metatarsal (HP:0010743)1.93313364
103Femoral bowing (HP:0002980)1.92160819
104Neonatal respiratory distress (HP:0002643)1.84536539
105Macroglossia (HP:0000158)1.84217282
106Abnormality of molar (HP:0011077)1.83580548
107Abnormality of molar morphology (HP:0011070)1.83580548
108Abnormality of the phalanges of the 5th finger (HP:0004213)1.83445436
109Preauricular pit (HP:0004467)1.82757547
110Periauricular skin pits (HP:0100277)1.82757547
111Ventricular fibrillation (HP:0001663)1.81502871
112Abnormality of potassium homeostasis (HP:0011042)1.80984498
113Absent toe (HP:0010760)1.80004464
114Ulnar bowing (HP:0003031)1.78983836
115Aortic dissection (HP:0002647)1.77622155
116Neoplasm of the thyroid gland (HP:0100031)1.77594769
117Bell-shaped thorax (HP:0001591)1.76920990
118Testicular neoplasm (HP:0010788)1.75825838
119Bowing of the arm (HP:0006488)1.75791417
120Bowed forearm bones (HP:0003956)1.75791417
121Hypoplastic labia majora (HP:0000059)1.75138925
122Abnormality of the dental pulp (HP:0006479)1.75016420
123Abnormal vertebral ossification (HP:0100569)1.74778549
124Constipation (HP:0002019)1.74728422
125Peripheral hypomyelination (HP:0007182)1.73918260
126Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.73910073
127Short nail (HP:0001799)1.73461023
128Increased connective tissue (HP:0009025)1.72215244
129Abnormal urine output (HP:0012590)1.71860224
130Abnormality of magnesium homeostasis (HP:0004921)1.71801301
131Fragile skin (HP:0001030)1.71391681
132Asymmetric growth (HP:0100555)1.70929272
133Keratoconus (HP:0000563)1.70892666
134Increased corneal curvature (HP:0100692)1.70892666
135Syringomyelia (HP:0003396)1.69001698
136Spinal cord lesions (HP:0100561)1.69001698
137Muscle fiber splitting (HP:0003555)1.68278485
138Neonatal short-limb short stature (HP:0008921)1.68075107
139Hyperaldosteronism (HP:0000859)1.67720587
140Hypoplasia of the uterus (HP:0000013)1.67073963
141Abnormality of the middle phalanges of the hand (HP:0009833)1.65765474
142Hepatoblastoma (HP:0002884)1.64356347
143Diaphragmatic weakness (HP:0009113)1.62511345
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61673939
145Abnormality of renal excretion (HP:0011036)1.58231205
146Vascular calcification (HP:0004934)1.55196000
147Cardiovascular calcification (HP:0011915)1.52119805
148Abnormality of sodium homeostasis (HP:0010931)1.51991453
149Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.50167912
150Hyponatremia (HP:0002902)1.47688511
151Preaxial foot polydactyly (HP:0001841)1.46224139
152Proximal tubulopathy (HP:0000114)1.44729335
153Abnormality of the epiphyses of the hand (HP:0005924)1.43373830
154Steppage gait (HP:0003376)1.35700312
155Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.32966383
156Decreased circulating renin level (HP:0003351)1.32835954
157Broad hallux (HP:0010055)1.29744280
158Abdominal distention (HP:0003270)1.28685917
159Hypertensive crisis (HP:0100735)1.26850712
160Prolonged QT interval (HP:0001657)1.26183836
161Premature birth (HP:0001622)1.23586114
162Hyperkalemia (HP:0002153)1.23198307
163Abnormal drinking behavior (HP:0030082)1.22581889
164Polydipsia (HP:0001959)1.22581889
165Syncope (HP:0001279)1.20118793
166Small for gestational age (HP:0001518)1.20107235
1672-3 toe syndactyly (HP:0004691)1.18346554
168Onion bulb formation (HP:0003383)1.16973801
169Increased CSF protein (HP:0002922)1.15596382
170Broad toe (HP:0001837)1.15289197
171Chondrocalcinosis (HP:0000934)1.14845393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.81922057
2RIPK14.64727920
3OXSR13.47333313
4EPHB23.03185158
5MST42.99792422
6MAP3K22.87299437
7MAP3K32.81840938
8NEK12.61570283
9EPHB12.47274340
10DDR22.28956132
11FGFR22.10147644
12PAK31.96166337
13EPHA31.95825868
14TESK11.94650225
15FRK1.93022322
16ERBB31.90392406
17SGK21.81736845
18FER1.76148529
19DAPK21.65247533
20MAP2K21.62755423
21MYLK1.60247398
22TRIB31.58071024
23SGK31.55525098
24ZAK1.51233410
25LATS11.48092290
26RPS6KA51.47960708
27ERN11.45518525
28SGK4941.43330629
29SGK2231.43330629
30SIK11.42732488
31HIPK21.41026808
32STK38L1.33262285
33AKT31.32858165
34TYRO31.27522290
35MAP3K41.27125177
36LMTK21.20001073
37PDGFRA1.15242626
38PAK41.12414663
39NME11.11418408
40TAOK11.11181930
41STK241.10343669
42PTK61.09116383
43BMPR21.05517892
44RPS6KA11.04684574
45PDK21.03705609
46TTN1.03464378
47GSK3A1.01115091
48NLK1.01070565
49LRRK21.00102875
50PNCK0.97078077
51MAPK150.96884170
52DMPK0.95529406
53ILK0.94354180
54MST1R0.89714031
55LIMK10.87847944
56RPS6KA20.87836248
57MAP2K10.87293535
58TIE10.87088646
59RET0.86888785
60FGFR10.86798134
61TRPM70.86239894
62ROCK10.84646056
63LATS20.82846589
64BRD40.82258982
65CLK10.81079802
66RPS6KA40.79519000
67KDR0.78907166
68PDK40.78829060
69PDK30.78829060
70MAPK120.76969159
71FGFR40.76629020
72CSNK1A1L0.75119991
73STK390.73951396
74IRAK10.72927073
75MAPKAPK20.71771225
76PDGFRB0.71542731
77RPS6KB20.70501325
78ROCK20.69094370
79MAP3K70.67762165
80EPHA20.66104773
81MAP2K30.64724329
82PDPK10.63850710
83STK100.63329769
84MAPK40.61968194
85MAPKAPK30.61404243
86PINK10.59734423
87NUAK10.59236436
88CDK120.58431770
89DYRK30.56462596
90NEK90.56437241
91PRKCI0.53275119
92STK380.52864645
93CAMK40.52498894
94ERBB20.51057425
95PTK20.50880429
96NEK60.50453722
97NTRK10.49819627
98PRKCE0.48929300
99MKNK20.48442413
100RPS6KL10.47936514
101RPS6KC10.47936514
102BMPR1B0.47667123
103TAOK20.47505109
104WNK10.46381654
105BMX0.46032817
106PTK2B0.45325158
107PRKG20.44706536
108MELK0.44380948
109MAPK70.43407122
110YES10.43058138
111CDK30.42689364
112TGFBR10.41604083
113SGK10.39621318
114RPS6KA60.39283187
115STK30.38583081
116PRKD10.38330015
117CSNK1A10.38029466
118MTOR0.37272687
119PRKCG0.37193007
120PAK20.37121090
121CSNK1G10.36970611
122MAPKAPK50.36926466
123PHKG10.36770185
124PHKG20.36770185
125CASK0.35732287
126ICK0.34677781
127MARK20.34365078
128PDK10.33210030
129MET0.32691580
130FGFR30.32520004
131JAK10.31533628
132RPS6KB10.31203517
133INSRR0.31134108
134DYRK1A0.28178993
135PRKD20.27970588
136PRKG10.27942054
137WNK40.26117012
138MAPK80.24848676
139BRSK20.24580453
140RPS6KA30.21689109
141PRKACA0.21167053
142MAPK100.20613854
143CSF1R0.20572431
144PRKAA20.20568052
145MAPK10.17464549
146AKT20.16224727
147PRKD30.15423686
148CSNK1D0.14873014
149PRKCZ0.14847214
150GRK10.13101129

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053205.16286151
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.48284839
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.46191299
4Chemical carcinogenesis_Homo sapiens_hsa052043.86179108
5Thyroid hormone synthesis_Homo sapiens_hsa049183.62787999
6Pentose and glucuronate interconversions_Homo sapiens_hsa000403.08306580
7Steroid hormone biosynthesis_Homo sapiens_hsa001403.04326148
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.83673025
9Glutathione metabolism_Homo sapiens_hsa004802.73415326
10Sulfur metabolism_Homo sapiens_hsa009202.33090509
11Tyrosine metabolism_Homo sapiens_hsa003502.03953151
12ECM-receptor interaction_Homo sapiens_hsa045121.73819634
13Mineral absorption_Homo sapiens_hsa049781.64582916
14Retinol metabolism_Homo sapiens_hsa008301.57888644
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49297306
16Histidine metabolism_Homo sapiens_hsa003401.41695371
17Amoebiasis_Homo sapiens_hsa051461.35132025
18Cocaine addiction_Homo sapiens_hsa050301.19063492
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16334768
20Inositol phosphate metabolism_Homo sapiens_hsa005621.14743044
21Adherens junction_Homo sapiens_hsa045201.09726119
22Tryptophan metabolism_Homo sapiens_hsa003801.04882691
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.02981496
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02908095
25Focal adhesion_Homo sapiens_hsa045101.02293609
26Starch and sucrose metabolism_Homo sapiens_hsa005001.00239219
27Prostate cancer_Homo sapiens_hsa052150.99815446
28Sphingolipid metabolism_Homo sapiens_hsa006000.98967869
29* Gastric acid secretion_Homo sapiens_hsa049710.98408298
30TGF-beta signaling pathway_Homo sapiens_hsa043500.97688111
31Small cell lung cancer_Homo sapiens_hsa052220.97116246
32Protein digestion and absorption_Homo sapiens_hsa049740.93851852
33Bile secretion_Homo sapiens_hsa049760.93596209
34Basal cell carcinoma_Homo sapiens_hsa052170.91339950
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89234862
36Renin secretion_Homo sapiens_hsa049240.86514453
37Hippo signaling pathway_Homo sapiens_hsa043900.85483003
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85055113
39Thyroid cancer_Homo sapiens_hsa052160.81326646
40Rheumatoid arthritis_Homo sapiens_hsa053230.79525568
41Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77535627
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77000268
43Proteoglycans in cancer_Homo sapiens_hsa052050.75641382
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75568191
45Toxoplasmosis_Homo sapiens_hsa051450.72979665
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71156634
47Tight junction_Homo sapiens_hsa045300.69606289
48TNF signaling pathway_Homo sapiens_hsa046680.69473903
49Phenylalanine metabolism_Homo sapiens_hsa003600.69063829
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68009974
51Ovarian steroidogenesis_Homo sapiens_hsa049130.67749069
52African trypanosomiasis_Homo sapiens_hsa051430.67683818
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66883737
54Melanogenesis_Homo sapiens_hsa049160.66070378
55Axon guidance_Homo sapiens_hsa043600.65759295
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65565306
57beta-Alanine metabolism_Homo sapiens_hsa004100.64653724
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64066290
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62856580
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59962704
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57563581
62Insulin resistance_Homo sapiens_hsa049310.56627336
63Hedgehog signaling pathway_Homo sapiens_hsa043400.54475357
64Pathways in cancer_Homo sapiens_hsa052000.54234889
65Circadian rhythm_Homo sapiens_hsa047100.53905198
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53902455
67Notch signaling pathway_Homo sapiens_hsa043300.52067223
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51836817
69Hepatitis C_Homo sapiens_hsa051600.51297157
70Prion diseases_Homo sapiens_hsa050200.49971761
71Collecting duct acid secretion_Homo sapiens_hsa049660.49375507
72Fatty acid degradation_Homo sapiens_hsa000710.47002903
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46308316
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44712601
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44629484
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.44342829
77Prolactin signaling pathway_Homo sapiens_hsa049170.44292226
78Estrogen signaling pathway_Homo sapiens_hsa049150.44279418
79Vitamin digestion and absorption_Homo sapiens_hsa049770.43948374
80Glioma_Homo sapiens_hsa052140.43074277
81cAMP signaling pathway_Homo sapiens_hsa040240.43003361
82mTOR signaling pathway_Homo sapiens_hsa041500.42694877
83N-Glycan biosynthesis_Homo sapiens_hsa005100.39702011
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39207917
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38898391
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38191663
87Arginine and proline metabolism_Homo sapiens_hsa003300.37731183
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36860493
89Sulfur relay system_Homo sapiens_hsa041220.36413478
90Wnt signaling pathway_Homo sapiens_hsa043100.36404788
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.36387208
92MicroRNAs in cancer_Homo sapiens_hsa052060.35802496
93Vibrio cholerae infection_Homo sapiens_hsa051100.35318693
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.35072997
95Melanoma_Homo sapiens_hsa052180.34967782
96Galactose metabolism_Homo sapiens_hsa000520.34513423
97MAPK signaling pathway_Homo sapiens_hsa040100.34147241
98Rap1 signaling pathway_Homo sapiens_hsa040150.33403002
99Bladder cancer_Homo sapiens_hsa052190.33400331
100Dorso-ventral axis formation_Homo sapiens_hsa043200.32771790
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32558193
102Lysine degradation_Homo sapiens_hsa003100.32396502
103Pertussis_Homo sapiens_hsa051330.32394697
104Endometrial cancer_Homo sapiens_hsa052130.32046160
105Renal cell carcinoma_Homo sapiens_hsa052110.31760862
106Lysosome_Homo sapiens_hsa041420.31588905
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.30435390
108Antigen processing and presentation_Homo sapiens_hsa046120.29662229
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28874695
110FoxO signaling pathway_Homo sapiens_hsa040680.28543233
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28277716
112Colorectal cancer_Homo sapiens_hsa052100.28052458
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.27835090
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27656498
115Dilated cardiomyopathy_Homo sapiens_hsa054140.27554022
116Graft-versus-host disease_Homo sapiens_hsa053320.27006686
117Fatty acid biosynthesis_Homo sapiens_hsa000610.25934174
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25648454
119Complement and coagulation cascades_Homo sapiens_hsa046100.25371737
120Malaria_Homo sapiens_hsa051440.25338173
121Salivary secretion_Homo sapiens_hsa049700.25304911
122Amphetamine addiction_Homo sapiens_hsa050310.24965689
123GnRH signaling pathway_Homo sapiens_hsa049120.24814047
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24714407
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24600847
126Butanoate metabolism_Homo sapiens_hsa006500.24434770
127Choline metabolism in cancer_Homo sapiens_hsa052310.23940375
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.23701232
129Cholinergic synapse_Homo sapiens_hsa047250.23667351
130Arachidonic acid metabolism_Homo sapiens_hsa005900.23639365
131Pancreatic secretion_Homo sapiens_hsa049720.23258669
132Pancreatic cancer_Homo sapiens_hsa052120.23178920
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23037819
134Fructose and mannose metabolism_Homo sapiens_hsa000510.22920547
135Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21459864
136PPAR signaling pathway_Homo sapiens_hsa033200.19335847
137ErbB signaling pathway_Homo sapiens_hsa040120.19321674
138Propanoate metabolism_Homo sapiens_hsa006400.18497444
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.18241767
140AMPK signaling pathway_Homo sapiens_hsa041520.17885832

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