SLC26A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.94816014
2binding of sperm to zona pellucida (GO:0007339)9.49285889
3cell-cell recognition (GO:0009988)9.36895115
4cell wall macromolecule metabolic process (GO:0044036)9.24109413
5cell wall macromolecule catabolic process (GO:0016998)9.24109413
6plasma membrane fusion (GO:0045026)9.23955772
7spermatid development (GO:0007286)9.02504912
8reproduction (GO:0000003)8.62713910
9male meiosis (GO:0007140)8.61909782
10cilium movement (GO:0003341)8.61260241
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.56908919
12regulation of cilium movement (GO:0003352)8.40253630
13synaptonemal complex organization (GO:0070193)7.75282764
14synaptonemal complex assembly (GO:0007130)7.39063232
15single fertilization (GO:0007338)7.27066189
16sperm capacitation (GO:0048240)6.76762357
17DNA methylation involved in gamete generation (GO:0043046)6.70880025
18fertilization (GO:0009566)6.23855075
19male meiosis I (GO:0007141)6.12606659
20negative regulation of inclusion body assembly (GO:0090084)6.02224773
21* spermatogenesis (GO:0007283)5.96807097
22* male gamete generation (GO:0048232)5.95016467
23microtubule depolymerization (GO:0007019)5.79728268
24* gamete generation (GO:0007276)5.46790347
25chromosome organization involved in meiosis (GO:0070192)5.45200706
26organic cation transport (GO:0015695)5.31596966
27behavioral response to nicotine (GO:0035095)5.31178581
28germ cell development (GO:0007281)5.22785521
29ventricular system development (GO:0021591)5.21557998
30calcium ion-dependent exocytosis (GO:0017156)5.13929117
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.12587752
32meiotic nuclear division (GO:0007126)5.02309920
33seminiferous tubule development (GO:0072520)5.01050066
34meiosis I (GO:0007127)4.86997689
35protein localization to cilium (GO:0061512)4.82858722
36regulation of inclusion body assembly (GO:0090083)4.76300615
37regulation of microtubule-based movement (GO:0060632)4.65620423
38cell recognition (GO:0008037)4.63893300
39left/right pattern formation (GO:0060972)4.53174324
40fucose catabolic process (GO:0019317)4.51758481
41L-fucose metabolic process (GO:0042354)4.51758481
42L-fucose catabolic process (GO:0042355)4.51758481
43DNA deamination (GO:0045006)4.30207139
44* multicellular organismal reproductive process (GO:0048609)4.27265173
45microtubule severing (GO:0051013)4.23713720
46* meiotic cell cycle (GO:0051321)4.01747583
47protein polyglutamylation (GO:0018095)3.75413232
48axoneme assembly (GO:0035082)3.73447126
49intraciliary transport (GO:0042073)3.72730582
50synapsis (GO:0007129)3.72222079
51monoubiquitinated protein deubiquitination (GO:0035520)3.61835162
52indolalkylamine metabolic process (GO:0006586)3.61695596
53gene silencing by RNA (GO:0031047)3.59121986
54regulation of meiosis I (GO:0060631)3.54631719
55cellular ketone body metabolic process (GO:0046950)3.51584603
56response to pheromone (GO:0019236)3.51004814
57* multicellular organismal development (GO:0007275)3.47117739
58adaptation of signaling pathway (GO:0023058)3.45572983
59detection of light stimulus involved in visual perception (GO:0050908)3.42883643
60detection of light stimulus involved in sensory perception (GO:0050962)3.42883643
61cilium organization (GO:0044782)3.41304046
62detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37280742
63genitalia morphogenesis (GO:0035112)3.36663556
64regulation of spindle checkpoint (GO:0090231)3.32104084
65cilium assembly (GO:0042384)3.31757603
66platelet dense granule organization (GO:0060155)3.31436764
67meiotic cell cycle process (GO:1903046)3.30896402
68spermatid nucleus differentiation (GO:0007289)3.24229921
69microtubule-based movement (GO:0007018)3.22705479
70centriole assembly (GO:0098534)3.22303525
71tryptophan catabolic process (GO:0006569)3.21494389
72indole-containing compound catabolic process (GO:0042436)3.21494389
73indolalkylamine catabolic process (GO:0046218)3.21494389
74neural tube formation (GO:0001841)3.20549485
75ketone body metabolic process (GO:1902224)3.19887312
76negative regulation of mast cell activation (GO:0033004)3.15020062
77activated T cell proliferation (GO:0050798)3.12133135
78cilium morphogenesis (GO:0060271)3.10919909
79polyol catabolic process (GO:0046174)3.10058893
80tryptophan metabolic process (GO:0006568)3.09568255
81cellular component assembly involved in morphogenesis (GO:0010927)3.05847000
82kynurenine metabolic process (GO:0070189)2.98112368
83alditol metabolic process (GO:0019400)2.98025365
84glycerol ether metabolic process (GO:0006662)2.97199451
85protein K11-linked deubiquitination (GO:0035871)2.96990336
86single strand break repair (GO:0000012)2.94239449
87protein complex biogenesis (GO:0070271)2.93250377
88retinal cone cell development (GO:0046549)2.93075930
89microtubule polymerization or depolymerization (GO:0031109)2.90289918
90sulfation (GO:0051923)2.89335924
91DNA packaging (GO:0006323)2.88300110
92centriole replication (GO:0007099)2.87587437
93protein-cofactor linkage (GO:0018065)2.87020439
94preassembly of GPI anchor in ER membrane (GO:0016254)2.84975253
95positive regulation of defense response to virus by host (GO:0002230)2.83294130
96lactate metabolic process (GO:0006089)2.80458239
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80331424
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.80331424
99NADH dehydrogenase complex assembly (GO:0010257)2.80331424
100pyrimidine nucleobase catabolic process (GO:0006208)2.80271500
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.79968153
102nucleoside diphosphate phosphorylation (GO:0006165)2.79255853
103negative regulation of telomere maintenance (GO:0032205)2.79023094
104negative regulation of organelle assembly (GO:1902116)2.77694460
105chromosome condensation (GO:0030261)2.77370464
106nonmotile primary cilium assembly (GO:0035058)2.77032475
107cornea development in camera-type eye (GO:0061303)2.76682468
108regulation of action potential (GO:0098900)2.75492129
109establishment of protein localization to Golgi (GO:0072600)2.75299634
110indole-containing compound metabolic process (GO:0042430)2.74149216
111respiratory chain complex IV assembly (GO:0008535)2.73498560
112ether metabolic process (GO:0018904)2.72141571
113water-soluble vitamin biosynthetic process (GO:0042364)2.70004870
114neuronal action potential (GO:0019228)2.69048310
115chaperone-mediated protein complex assembly (GO:0051131)2.68555695
116gamma-aminobutyric acid transport (GO:0015812)2.68325562
117glycerol metabolic process (GO:0006071)2.66180028
118regulation of memory T cell differentiation (GO:0043380)2.65640554
119amino-acid betaine transport (GO:0015838)2.64980042
120carnitine transport (GO:0015879)2.64980042
121carnitine transmembrane transport (GO:1902603)2.64698336
122nucleus organization (GO:0006997)2.64489489
123regulation of centriole replication (GO:0046599)2.63560438
124negative regulation of interleukin-1 production (GO:0032692)2.63202687
125peptidyl-glutamic acid modification (GO:0018200)2.61977751
126mitochondrial respiratory chain complex assembly (GO:0033108)2.60996872
127synaptic transmission, cholinergic (GO:0007271)2.60643331
128cytidine deamination (GO:0009972)2.58847218
129cytidine metabolic process (GO:0046087)2.58847218
130cytidine catabolic process (GO:0006216)2.58847218
131primary amino compound metabolic process (GO:1901160)2.58400061
132rRNA catabolic process (GO:0016075)2.57028595
133photoreceptor cell development (GO:0042461)2.57019658
134regulation of chromatin binding (GO:0035561)2.56504549
135calcium ion import (GO:0070509)2.56457720
136negative regulation of interleukin-1 beta production (GO:0032691)2.56031949
137negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55541195
138mannosylation (GO:0097502)2.53675772
139cAMP catabolic process (GO:0006198)2.53629860
140left/right axis specification (GO:0070986)2.53223905
141kidney morphogenesis (GO:0060993)2.52902635
142cellular response to ATP (GO:0071318)2.52305846
143cytochrome complex assembly (GO:0017004)2.51854161
144phosphatidylinositol acyl-chain remodeling (GO:0036149)2.51752523
145mitotic sister chromatid cohesion (GO:0007064)2.51550439
146interferon-gamma secretion (GO:0072643)2.50964595
147DNA alkylation (GO:0006305)2.50838439
148DNA methylation (GO:0006306)2.50838439
149negative regulation of skeletal muscle tissue development (GO:0048642)2.48015221
150gene silencing (GO:0016458)2.47950406
151regulation of acrosome reaction (GO:0060046)2.46109219
152photoreceptor cell maintenance (GO:0045494)2.45370830
153protein targeting to Golgi (GO:0000042)2.44728815
154regulation of hexokinase activity (GO:1903299)2.43090830
155regulation of glucokinase activity (GO:0033131)2.43090830
156nucleobase catabolic process (GO:0046113)2.40876077
157somite development (GO:0061053)2.39761605
158serotonin metabolic process (GO:0042428)2.38261987
159interferon-gamma production (GO:0032609)2.34866671
160positive regulation of oligodendrocyte differentiation (GO:0048714)2.34449684
161pyrimidine ribonucleoside catabolic process (GO:0046133)2.32458794
162amine catabolic process (GO:0009310)2.32350952
163cellular biogenic amine catabolic process (GO:0042402)2.32350952
164GPI anchor metabolic process (GO:0006505)2.31448321
165auditory receptor cell stereocilium organization (GO:0060088)2.29221575
166spinal cord motor neuron differentiation (GO:0021522)2.28830476
167regulation of rhodopsin mediated signaling pathway (GO:0022400)2.27500124
168cilium or flagellum-dependent cell motility (GO:0001539)14.2004884
169sperm motility (GO:0030317)12.3248059
170fusion of sperm to egg plasma membrane (GO:0007342)12.0956101
171axonemal dynein complex assembly (GO:0070286)11.1198163
172acrosome reaction (GO:0007340)10.9686204
173piRNA metabolic process (GO:0034587)10.6569816
174multicellular organism reproduction (GO:0032504)10.5931980
175sperm-egg recognition (GO:0035036)10.4699614
176motile cilium assembly (GO:0044458)10.2549192
177acrosome assembly (GO:0001675)10.2182092

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.95846905
2EZH2_22144423_ChIP-Seq_EOC_Human5.98346916
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.06981129
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48720376
5GBX2_23144817_ChIP-Seq_PC3_Human2.96999263
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.36886518
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23914226
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22562646
9IGF1R_20145208_ChIP-Seq_DFB_Human2.19129495
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11342810
11VDR_22108803_ChIP-Seq_LS180_Human2.00535390
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.99250971
13FUS_26573619_Chip-Seq_HEK293_Human1.92570350
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92404717
15P300_19829295_ChIP-Seq_ESCs_Human1.91175558
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82073059
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72606842
18ZNF274_21170338_ChIP-Seq_K562_Hela1.71491077
19TP53_22573176_ChIP-Seq_HFKS_Human1.71113370
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.70004763
21EWS_26573619_Chip-Seq_HEK293_Human1.69390559
22* GATA1_26923725_Chip-Seq_HPCs_Mouse1.63274667
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62995262
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60566581
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59918089
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.59016249
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58618571
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58426657
29REST_21632747_ChIP-Seq_MESCs_Mouse1.58363308
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56876180
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56566247
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.56385888
33BCAT_22108803_ChIP-Seq_LS180_Human1.55163668
34STAT1_17558387_ChIP-Seq_HELA_Human1.55014740
35* TAL1_26923725_Chip-Seq_HPCs_Mouse1.51270878
36IRF1_19129219_ChIP-ChIP_H3396_Human1.49370203
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.48729164
38KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48533283
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47268627
40STAT3_23295773_ChIP-Seq_U87_Human1.46476368
41* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44932653
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44547429
43KDM2B_26808549_Chip-Seq_REH_Human1.43733204
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43430833
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43371745
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.42072458
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40114193
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.39889879
49AR_25329375_ChIP-Seq_VCAP_Human1.39546628
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38477977
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38477977
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37149012
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37043052
54CBP_20019798_ChIP-Seq_JUKART_Human1.37043052
55FOXA1_25329375_ChIP-Seq_VCAP_Human1.36828541
56FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36828541
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.34620133
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.34617695
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33330114
60SOX2_19829295_ChIP-Seq_ESCs_Human1.30592171
61NANOG_19829295_ChIP-Seq_ESCs_Human1.30592171
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.30586855
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29133440
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29133175
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28996135
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27970453
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27814601
68RNF2_27304074_Chip-Seq_NSC_Mouse1.27765588
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.27094211
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27055190
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.26179815
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25252275
73GATA3_21867929_ChIP-Seq_CD8_Mouse1.24863185
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24598999
75RUNX2_22187159_ChIP-Seq_PCA_Human1.23592929
76FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23310506
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23078269
78P53_22387025_ChIP-Seq_ESCs_Mouse1.22931951
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.22383285
80OCT4_18555785_Chip-Seq_ESCs_Mouse1.22187762
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21593212
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.20180016
83TCF4_22108803_ChIP-Seq_LS180_Human1.19692409
84AR_20517297_ChIP-Seq_VCAP_Human1.19225909
85GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.18075274
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.17540705
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16814855
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.16629812
89NCOR_22424771_ChIP-Seq_293T_Human1.16578701
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15262888
91P300_18555785_Chip-Seq_ESCs_Mouse1.15124072
92SOX2_22085726_ChIP-Seq_NPCs_Mouse1.14950294
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14548964
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14527019
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14459441
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.13638354
97DROSHA_22980978_ChIP-Seq_HELA_Human1.13638143
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13490156
99* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13222634
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12866363
101PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12572248
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.12041327
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.11992522
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.10712621
105GF1_26923725_Chip-Seq_HPCs_Mouse1.10435294
106NANOG_20526341_ChIP-Seq_ESCs_Human1.10357791
107AR_21572438_ChIP-Seq_LNCaP_Human1.10258952
108GATA3_21867929_ChIP-Seq_TH1_Mouse1.10252977
109MYC_18940864_ChIP-ChIP_HL60_Human1.08847833
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08512844
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07144320
112SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06812354
113FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06475290
114PU1_27457419_Chip-Seq_LIVER_Mouse1.06399416
115E2F1_18555785_Chip-Seq_ESCs_Mouse1.06345841
116MYC_19829295_ChIP-Seq_ESCs_Human1.05189181
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05105596
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04773050
119TAF15_26573619_Chip-Seq_HEK293_Human1.04453701
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03779373
121* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.03760239
122ERA_21632823_ChIP-Seq_H3396_Human1.03496254
123TCF4_23295773_ChIP-Seq_U87_Human1.03397726
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.03369008
125GATA3_26560356_Chip-Seq_TH2_Human1.03307363
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02937761
127RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02266591
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01914641
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01805384
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01322081
131RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01002732
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00878279
133RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99783681
134CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99617264
135GABP_17652178_ChIP-ChIP_JURKAT_Human0.99371449
136TAF2_19829295_ChIP-Seq_ESCs_Human0.98872064
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98712863
138NMYC_18555785_Chip-Seq_ESCs_Mouse0.98631377
139HOXB7_26014856_ChIP-Seq_BT474_Human0.98584085
140CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98513697
141ZFX_18555785_Chip-Seq_ESCs_Mouse0.97883953
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.96801605
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.96763394
144CTCF_18555785_Chip-Seq_ESCs_Mouse0.96555934
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96166293
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94905673
147ER_23166858_ChIP-Seq_MCF-7_Human0.94515603
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94252709
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93907986
150PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92825509
151P53_21459846_ChIP-Seq_SAOS-2_Human0.92424425
152* SMAD4_21799915_ChIP-Seq_A2780_Human0.91937725
153NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91409879
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.90302113
155SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89927008
156EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89815358
157* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89012194
158TBL1_22424771_ChIP-Seq_293T_Human0.87611226
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.84960700
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84922132
161POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84912665

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.74671891
2* MP0001929_abnormal_gametogenesis5.20558155
3MP0008877_abnormal_DNA_methylation4.84375686
4MP0002210_abnormal_sex_determination3.66221027
5* MP0002161_abnormal_fertility/fecundity3.04945751
6MP0001145_abnormal_male_reproductive3.02339766
7MP0002653_abnormal_ependyma_morphology2.81781134
8MP0000653_abnormal_sex_gland2.62746723
9MP0005670_abnormal_white_adipose2.23692328
10MP0003724_increased_susceptibility_to2.17055534
11MP0003195_calcinosis2.11246264
12* MP0005410_abnormal_fertilization14.2004459
13MP0004147_increased_porphyrin_level1.95606742
14MP0002160_abnormal_reproductive_system1.93868900
15MP0005623_abnormal_meninges_morphology1.89753143
16MP0004142_abnormal_muscle_tone1.88412338
17MP0008872_abnormal_physiological_respon1.71360799
18MP0006276_abnormal_autonomic_nervous1.70137297
19MP0006072_abnormal_retinal_apoptosis1.68992651
20MP0001984_abnormal_olfaction1.67130364
21MP0005084_abnormal_gallbladder_morpholo1.66495648
22MP0002277_abnormal_respiratory_mucosa1.62443178
23MP0008875_abnormal_xenobiotic_pharmacok1.60661755
24MP0003646_muscle_fatigue1.60477773
25MP0009046_muscle_twitch1.57764023
26MP0004885_abnormal_endolymph1.57121561
27MP0008057_abnormal_DNA_replication1.56558049
28MP0008058_abnormal_DNA_repair1.51800123
29MP0004133_heterotaxia1.47723943
30MP0000372_irregular_coat_pigmentation1.46006053
31MP0005075_abnormal_melanosome_morpholog1.44279952
32MP0004043_abnormal_pH_regulation1.42213668
33MP0001485_abnormal_pinna_reflex1.41568903
34MP0008995_early_reproductive_senescence1.33866202
35MP0003136_yellow_coat_color1.31849303
36MP0002733_abnormal_thermal_nociception1.31362578
37MP0001970_abnormal_pain_threshold1.30315309
38MP0002837_dystrophic_cardiac_calcinosis1.30188205
39MP0000427_abnormal_hair_cycle1.28778845
40MP0005671_abnormal_response_to1.28300415
41MP0002938_white_spotting1.24527409
42MP0000015_abnormal_ear_pigmentation1.21356085
43MP0005647_abnormal_sex_gland1.20876297
44MP0001919_abnormal_reproductive_system1.16685888
45MP0009764_decreased_sensitivity_to1.13765685
46MP0003121_genomic_imprinting1.13453149
47MP0001529_abnormal_vocalization1.13072731
48MP0001905_abnormal_dopamine_level1.12888154
49MP0000569_abnormal_digit_pigmentation1.12195069
50MP0003122_maternal_imprinting1.09541510
51MP0002282_abnormal_trachea_morphology1.07023641
52MP0005174_abnormal_tail_pigmentation1.04782176
53MP0005389_reproductive_system_phenotype0.98904150
54MP0005646_abnormal_pituitary_gland0.98779322
55MP0005551_abnormal_eye_electrophysiolog0.97594405
56MP0004924_abnormal_behavior0.97347194
57MP0005386_behavior/neurological_phenoty0.97347194
58MP0001765_abnormal_ion_homeostasis0.94769695
59MP0009785_altered_susceptibility_to0.93867737
60MP0002095_abnormal_skin_pigmentation0.92702977
61MP0003252_abnormal_bile_duct0.92139014
62MP0010094_abnormal_chromosome_stability0.91932728
63MP0005167_abnormal_blood-brain_barrier0.90634491
64MP0005195_abnormal_posterior_eye0.88471810
65MP0000230_abnormal_systemic_arterial0.86553918
66MP0003786_premature_aging0.86457385
67MP0002693_abnormal_pancreas_physiology0.83830761
68MP0006292_abnormal_olfactory_placode0.83610636
69MP0001800_abnormal_humoral_immune0.82642466
70MP0002138_abnormal_hepatobiliary_system0.82639297
71MP0000685_abnormal_immune_system0.82529940
72MP0003878_abnormal_ear_physiology0.82452447
73MP0005377_hearing/vestibular/ear_phenot0.82452447
74MP0003011_delayed_dark_adaptation0.82199095
75MP0002734_abnormal_mechanical_nocicepti0.81871708
76MP0001440_abnormal_grooming_behavior0.79839945
77MP0002572_abnormal_emotion/affect_behav0.77188017
78MP0008789_abnormal_olfactory_epithelium0.77120301
79MP0003635_abnormal_synaptic_transmissio0.76619468
80MP0004859_abnormal_synaptic_plasticity0.76453670
81MP0009745_abnormal_behavioral_response0.74135848
82MP0002909_abnormal_adrenal_gland0.73469689
83MP0005085_abnormal_gallbladder_physiolo0.73365727
84MP0002163_abnormal_gland_morphology0.73231397
85MP0002102_abnormal_ear_morphology0.72379485
86MP0003880_abnormal_central_pattern0.71451517
87MP0004808_abnormal_hematopoietic_stem0.71222566
88MP0002063_abnormal_learning/memory/cond0.70017329
89MP0002723_abnormal_immune_serum0.69900407
90MP0005379_endocrine/exocrine_gland_phen0.69888391
91MP0008007_abnormal_cellular_replicative0.69182512
92MP0001486_abnormal_startle_reflex0.68332346
93MP0002736_abnormal_nociception_after0.68105761
94MP0004233_abnormal_muscle_weight0.68093391
95MP0002638_abnormal_pupillary_reflex0.64221435
96MP0001968_abnormal_touch/_nociception0.63836093
97MP0001502_abnormal_circadian_rhythm0.63560040
98MP0004134_abnormal_chest_morphology0.62735043
99MP0003111_abnormal_nucleus_morphology0.62200998
100MP0002928_abnormal_bile_duct0.61256941
101MP0005253_abnormal_eye_physiology0.60656887
102MP0001324_abnormal_eye_pigmentation0.60366671
103MP0001119_abnormal_female_reproductive0.60340056
104MP0003879_abnormal_hair_cell0.59824892
105MP0001986_abnormal_taste_sensitivity0.59380812
106MP0005423_abnormal_somatic_nervous0.56561077
107MP0002272_abnormal_nervous_system0.53945441
108MP0010386_abnormal_urinary_bladder0.52583176
109MP0003787_abnormal_imprinting0.52365845
110MP0003699_abnormal_female_reproductive0.51827586
111MP0002876_abnormal_thyroid_physiology0.50854026
112MP0001501_abnormal_sleep_pattern0.50495278
113MP0002064_seizures0.50023164
114MP0002234_abnormal_pharynx_morphology0.46198821
115MP0005397_hematopoietic_system_phenotyp0.46027166
116MP0001545_abnormal_hematopoietic_system0.46027166
117MP0004742_abnormal_vestibular_system0.44350758
118MP0002067_abnormal_sensory_capabilities0.42759255
119MP0002152_abnormal_brain_morphology0.42138399
120MP0001835_abnormal_antigen_presentation0.41779887
121MP0005645_abnormal_hypothalamus_physiol0.41719504
122MP0004811_abnormal_neuron_physiology0.41493657
123MP0001188_hyperpigmentation0.41412035
124MP0002557_abnormal_social/conspecific_i0.40235678
125MP0005409_darkened_coat_color0.39776619
126MP0005636_abnormal_mineral_homeostasis0.39190195
127MP0003045_fibrosis0.37922798
128MP0000358_abnormal_cell_content/0.37088458
129MP0003183_abnormal_peptide_metabolism0.36952046
130MP0000631_abnormal_neuroendocrine_gland0.36858238
131MP0002148_abnormal_hypersensitivity_rea0.36730806
132MP0003115_abnormal_respiratory_system0.35811285
133MP0002405_respiratory_system_inflammati0.35545565
134MP0001963_abnormal_hearing_physiology0.34995888
135MP0002822_catalepsy0.34900460
136MP0005391_vision/eye_phenotype0.34826063
137MP0002971_abnormal_brown_adipose0.34734563
138MP0003631_nervous_system_phenotype0.34527987
139MP0009115_abnormal_fat_cell0.34312417
140MP0002229_neurodegeneration0.34023278
141MP0003329_amyloid_beta_deposits0.33945805
142MP0002735_abnormal_chemical_nociception0.33863720
143MP0000026_abnormal_inner_ear0.33463385
144MP0001764_abnormal_homeostasis0.32518610
145MP0002752_abnormal_somatic_nervous0.32512938
146MP0008569_lethality_at_weaning0.32322378
147MP0003633_abnormal_nervous_system0.32281844
148MP0001293_anophthalmia0.31707007
149MP0003861_abnormal_nervous_system0.31426338

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.94807803
2Abnormal respiratory motile cilium morphology (HP:0005938)8.92992083
3Abnormal respiratory epithelium morphology (HP:0012253)8.92992083
4Rhinitis (HP:0012384)7.58343008
5Abnormal ciliary motility (HP:0012262)7.27298419
6Chronic bronchitis (HP:0004469)6.47400588
7Infertility (HP:0000789)5.92394553
8Nasal polyposis (HP:0100582)5.90963375
9Abnormality of the nasal mucosa (HP:0000433)4.70925203
10Nephronophthisis (HP:0000090)4.70001415
11Bronchiectasis (HP:0002110)4.37404665
12Bronchitis (HP:0012387)4.08602984
13Congenital stationary night blindness (HP:0007642)3.96696600
14Abnormality of the renal medulla (HP:0100957)3.60421752
15Type II lissencephaly (HP:0007260)3.38752750
16Recurrent sinusitis (HP:0011108)3.28852732
17Chronic hepatic failure (HP:0100626)3.24174261
18Attenuation of retinal blood vessels (HP:0007843)3.19642743
19Gonadotropin excess (HP:0000837)3.19364934
20Abnormal rod and cone electroretinograms (HP:0008323)3.08777547
21Recurrent otitis media (HP:0000403)3.08718156
22Male infertility (HP:0003251)3.06127323
23Abnormal spermatogenesis (HP:0008669)3.02951892
24Abolished electroretinogram (ERG) (HP:0000550)2.99658028
25Hyperventilation (HP:0002883)2.85756359
26Tubulointerstitial nephritis (HP:0001970)2.82872164
27Stomatitis (HP:0010280)2.78646344
28Abnormality of midbrain morphology (HP:0002418)2.77699601
29Molar tooth sign on MRI (HP:0002419)2.77699601
30Medial flaring of the eyebrow (HP:0010747)2.75132877
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67249265
32Impulsivity (HP:0100710)2.59757874
33Recurrent bronchitis (HP:0002837)2.49404581
34Sclerocornea (HP:0000647)2.46528185
35Abnormality of the lower motor neuron (HP:0002366)2.46365723
36Cerebellar dysplasia (HP:0007033)2.42465895
37Tubular atrophy (HP:0000092)2.40021917
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38282715
39Progressive cerebellar ataxia (HP:0002073)2.34893272
40Hypothermia (HP:0002045)2.34532382
41Lissencephaly (HP:0001339)2.34317353
42Inability to walk (HP:0002540)2.33955308
43Azoospermia (HP:0000027)2.33801061
44Pendular nystagmus (HP:0012043)2.33584525
45Bony spicule pigmentary retinopathy (HP:0007737)2.32499911
46Renal cortical cysts (HP:0000803)2.29407887
47Polyuria (HP:0000103)2.29041780
48Fibular hypoplasia (HP:0003038)2.28488326
49Postaxial foot polydactyly (HP:0001830)2.26873290
50Tubulointerstitial abnormality (HP:0001969)2.26345974
51Stomach cancer (HP:0012126)2.18013197
52Hypoplasia of the fovea (HP:0007750)2.17732788
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.17732788
54Progressive inability to walk (HP:0002505)2.15041580
55Anencephaly (HP:0002323)2.11591001
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10099295
57Abnormality of alanine metabolism (HP:0010916)2.10099295
58Hyperalaninemia (HP:0003348)2.10099295
59Increased corneal curvature (HP:0100692)2.08709615
60Keratoconus (HP:0000563)2.08709615
61Acute necrotizing encephalopathy (HP:0006965)2.07584621
62Chronic sinusitis (HP:0011109)2.06929584
63Furrowed tongue (HP:0000221)2.05293453
64Broad-based gait (HP:0002136)2.04583242
65Large for gestational age (HP:0001520)2.03372895
66Stage 5 chronic kidney disease (HP:0003774)2.02582030
67Mitochondrial inheritance (HP:0001427)2.02452350
68Optic nerve hypoplasia (HP:0000609)2.02016338
69Abnormality of the pons (HP:0007361)2.00753887
70Increased CSF lactate (HP:0002490)2.00330980
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7689731
72Absent/shortened dynein arms (HP:0200106)12.3991746
73Dynein arm defect of respiratory motile cilia (HP:0012255)12.3991746
74Male pseudohermaphroditism (HP:0000037)1.98187598
75Abnormality of the renal cortex (HP:0011035)1.98154606
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.97828031
77Congenital hepatic fibrosis (HP:0002612)1.97711123
78Decreased circulating renin level (HP:0003351)1.96721635
79Elevated erythrocyte sedimentation rate (HP:0003565)1.96713093
80Hypoplasia of the pons (HP:0012110)1.96164698
81Congenital sensorineural hearing impairment (HP:0008527)1.95381283
82Febrile seizures (HP:0002373)1.94936400
83Amyotrophic lateral sclerosis (HP:0007354)1.94223558
84Protruding tongue (HP:0010808)1.93995800
85Abnormality of the fovea (HP:0000493)1.92955479
86Optic disc pallor (HP:0000543)1.92331828
87Hypochromic microcytic anemia (HP:0004840)1.90464115
88Progressive macrocephaly (HP:0004481)1.89544802
893-Methylglutaconic aciduria (HP:0003535)1.88433297
90Impaired proprioception (HP:0010831)1.86178747
91Congenital, generalized hypertrichosis (HP:0004540)1.86028913
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.85829345
93Focal motor seizures (HP:0011153)1.85112927
94Polyphagia (HP:0002591)1.84925453
95Abnormality of macular pigmentation (HP:0008002)1.83509454
96Genetic anticipation (HP:0003743)1.82486671
97Abnormal urine output (HP:0012590)1.82139063
98Genital tract atresia (HP:0001827)1.80784765
99Decreased central vision (HP:0007663)1.79528014
100Myositis (HP:0100614)1.78666860
101Renal dysplasia (HP:0000110)1.78192429
102Supernumerary spleens (HP:0009799)1.77610930
103Oculomotor apraxia (HP:0000657)1.76941089
104IgG deficiency (HP:0004315)1.76387667
105Absent frontal sinuses (HP:0002688)1.76364680
106Concave nail (HP:0001598)1.75092389
107Dyschromatopsia (HP:0007641)1.74902974
108Abnormal mitochondria in muscle tissue (HP:0008316)1.74801040
109Absent speech (HP:0001344)1.74733803
110Acute encephalopathy (HP:0006846)1.74617718
111Severe muscular hypotonia (HP:0006829)1.74591173
112Limb dystonia (HP:0002451)1.74079184
113Vaginal atresia (HP:0000148)1.73393205
114Clumsiness (HP:0002312)1.72708812
115Congenital primary aphakia (HP:0007707)1.72199391
116Postaxial hand polydactyly (HP:0001162)1.71590773
117Gait imbalance (HP:0002141)1.70707133
118Spastic tetraparesis (HP:0001285)1.70657241
119Polydipsia (HP:0001959)1.70603640
120Abnormal drinking behavior (HP:0030082)1.70603640
121True hermaphroditism (HP:0010459)1.68686796
122Tubulointerstitial fibrosis (HP:0005576)1.66582543
123Abnormal biliary tract physiology (HP:0012439)1.63807561
124Bile duct proliferation (HP:0001408)1.63807561
125Abnormality of the dental root (HP:0006486)1.63636164
126Taurodontia (HP:0000679)1.63636164
127Abnormality of permanent molar morphology (HP:0011071)1.63636164
128Pancreatic fibrosis (HP:0100732)1.63560227
129Facial cleft (HP:0002006)1.62557041
130Abnormality of molar morphology (HP:0011070)1.61378072
131Abnormality of molar (HP:0011077)1.61378072
132Median cleft lip (HP:0000161)1.61089188
133Aplasia/Hypoplasia of the lens (HP:0008063)1.60174050
134Cystic liver disease (HP:0006706)1.59665700
135Bell-shaped thorax (HP:0001591)1.57373718
136Nephrogenic diabetes insipidus (HP:0009806)1.53231717
137Retinal dysplasia (HP:0007973)1.51793890
138Gaze-evoked nystagmus (HP:0000640)1.51644364
139Absent epiphyses (HP:0010577)1.50443838
140Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50443838
141Nephropathy (HP:0000112)1.46288409
142Abnormality of the dental pulp (HP:0006479)1.45434108
143Short ribs (HP:0000773)1.45430024
144Hemiparesis (HP:0001269)1.45027438
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.44614287
146Heterotopia (HP:0002282)1.43175966
147Upper motor neuron abnormality (HP:0002127)1.41974984
148Short thorax (HP:0010306)1.41966158
149Short femoral neck (HP:0100864)1.39718810
150Choroideremia (HP:0001139)1.38711083
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.38057804
152Abnormality of the anterior horn cell (HP:0006802)1.37512125
153Degeneration of anterior horn cells (HP:0002398)1.37512125
154J-shaped sella turcica (HP:0002680)1.35798484
155Abnormality of dentin (HP:0010299)1.35739222
156Abnormality of renal excretion (HP:0011036)1.35607517
157Abnormality of ocular smooth pursuit (HP:0000617)1.34943519
158Poor coordination (HP:0002370)1.32980492
159Microglossia (HP:0000171)1.31147246
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.31045399
161Retrobulbar optic neuritis (HP:0100654)1.29324164
162Optic neuritis (HP:0100653)1.29324164
163Pancreatic cysts (HP:0001737)1.29212222
164Severe visual impairment (HP:0001141)1.25955973
165Pachygyria (HP:0001302)1.25674056
166Easy fatigability (HP:0003388)1.24656749
16711 pairs of ribs (HP:0000878)1.23782582
168Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.23070540

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.18128566
2PDK48.18128566
3PDK25.30778560
4TESK14.96769934
5PRKD34.75297087
6FRK4.50927724
7ICK3.62768583
8TLK13.12700207
9TAOK32.56047414
10MAP4K22.45357370
11PTK2B2.25348414
12PNCK2.18615411
13INSRR2.15182903
14NUAK12.09015969
15WNK42.03134542
16ACVR1B2.00481135
17STK391.97133739
18STK381.71521380
19OXSR11.69300204
20NEK21.65659894
21DAPK21.43164297
22MAP3K41.42779568
23CCNB11.42724855
24MUSK1.29551718
25BMPR1B1.28700127
26DYRK21.23769301
27GRK71.23719119
28PINK11.23233285
29ADRBK11.16262400
30PAK31.15117453
31SIK21.14263894
32BCKDK1.13473176
33YES11.12319177
34GRK61.10018922
35PHKG11.09785609
36PHKG21.09785609
37CDK191.08295396
38MAPK151.06900215
39TEC1.05289348
40RIPK41.03927103
41TIE11.03825933
42PRPF4B0.98100014
43MARK30.92159786
44WNK10.88765528
45PDK10.87627441
46IRAK10.87328197
47STK30.87317727
48DYRK30.86189587
49NTRK20.85511027
50MAP4K10.83383715
51IKBKB0.80537303
52PRKCE0.78978849
53DYRK1B0.76459278
54KIT0.76421808
55CSNK1G20.72784080
56PLK40.71841581
57MAP2K40.71688888
58BMPR20.70927865
59TTK0.68716143
60ITK0.67578827
61TRIM280.67347399
62IKBKE0.64810660
63NME10.62927520
64PASK0.62266130
65TGFBR10.61699963
66EPHA40.60379248
67CHEK20.59853331
68FES0.59499173
69STK110.58658540
70MKNK20.58145719
71CSNK1G30.58057952
72NEK60.57728001
73ZAK0.55595301
74MAP3K110.55336962
75CSNK1G10.55085036
76EPHA30.53186721
77LYN0.52438579
78IRAK20.51183491
79ATR0.51154026
80VRK10.49785794
81RPS6KA50.46853048
82PKN10.46708050
83CAMK1G0.46687140
84TNIK0.45908789
85PIK3CA0.45544059
86CDK30.44481821
87PRKCG0.43549093
88BRAF0.43480573
89TYRO30.42816576
90CHEK10.42000337
91CASK0.41689623
92TXK0.40174585
93PRKCI0.39928493
94MAP2K70.39868995
95CAMKK10.38689645
96CSNK1A1L0.38511028
97NLK0.38195563
98TNK20.36147134
99LCK0.35799684
100CHUK0.35747404
101MAP2K60.34504991
102PDPK10.33758051
103ATM0.33475482
104GRK50.33096124
105BCR0.33073554
106MARK20.32941763
107BRSK20.28794692
108CDC70.28700392
109PLK20.28506694
110MAP2K10.28020797
111RPS6KB10.27745768
112GRK10.27337315
113ABL10.26760326
114WNK30.23348273
115PLK10.23009123
116AKT30.22833824
117IRAK40.22361377
118PAK10.21381902
119NTRK30.20804270
120STK38L0.20644067
121EIF2AK20.18252449
122PRKAA10.17345529
123CAMK10.17166317
124MARK10.17013909
125ADRBK20.16919431
126WEE10.16879347
127PRKG10.16270232
128STK160.15897923
129MAPK130.15852933
130CAMK2A0.15599247
131SGK20.12732670
132LMTK20.11628099
133PRKCQ0.11352824
134DYRK1A0.11282207
135SYK0.11252113
136GSK3B0.10663225
137PAK60.08765074
138PRKCZ0.08644991
139MAPKAPK50.08134251
140ZAP700.07224190
141PRKCA0.06526640
142MAPK80.06432081
143CAMKK20.05991681
144CDK10.05327467
145MST1R0.04752514
146PRKACB0.04425773
147SIK30.04371426
148PRKCD0.04296616
149PRKCB0.04205101
150CSNK1D0.03976753
151HCK0.03615734
152PRKG20.03209188
153BTK0.03133103
154PIM10.02711603
155PRKACA0.01971210
156MTOR0.01376291

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.45379266
2Fanconi anemia pathway_Homo sapiens_hsa034602.93085830
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.85246059
4Dorso-ventral axis formation_Homo sapiens_hsa043202.74748305
5Fatty acid biosynthesis_Homo sapiens_hsa000612.67804023
6Basal transcription factors_Homo sapiens_hsa030222.59933051
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52557583
8Linoleic acid metabolism_Homo sapiens_hsa005912.36570995
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.33886193
10Pyruvate metabolism_Homo sapiens_hsa006202.31516014
11Oxidative phosphorylation_Homo sapiens_hsa001902.26131683
12Butanoate metabolism_Homo sapiens_hsa006502.25668208
13Nitrogen metabolism_Homo sapiens_hsa009102.23063975
14Glucagon signaling pathway_Homo sapiens_hsa049222.21558294
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.19475250
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12259434
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09835537
18Amphetamine addiction_Homo sapiens_hsa050312.05256157
19Nicotine addiction_Homo sapiens_hsa050331.96502357
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88163301
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.84307697
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81726430
23Pentose phosphate pathway_Homo sapiens_hsa000301.74630819
24Propanoate metabolism_Homo sapiens_hsa006401.70910080
25Parkinsons disease_Homo sapiens_hsa050121.70314318
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64076923
27Oocyte meiosis_Homo sapiens_hsa041141.58852844
28Glycerolipid metabolism_Homo sapiens_hsa005611.55068900
29Primary immunodeficiency_Homo sapiens_hsa053401.52420075
30Taste transduction_Homo sapiens_hsa047421.52048671
31Selenocompound metabolism_Homo sapiens_hsa004501.47129372
32Tryptophan metabolism_Homo sapiens_hsa003801.46790781
33Renin secretion_Homo sapiens_hsa049241.44704282
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.40460090
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40138312
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39644682
37Long-term potentiation_Homo sapiens_hsa047201.36880739
38Protein export_Homo sapiens_hsa030601.36833452
39RNA polymerase_Homo sapiens_hsa030201.36305168
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.32923505
41Calcium signaling pathway_Homo sapiens_hsa040201.28738969
42Caffeine metabolism_Homo sapiens_hsa002321.27316478
43Huntingtons disease_Homo sapiens_hsa050161.26111019
44Ether lipid metabolism_Homo sapiens_hsa005651.24172233
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23355144
46Circadian entrainment_Homo sapiens_hsa047131.23354105
47Regulation of autophagy_Homo sapiens_hsa041401.21847133
48Purine metabolism_Homo sapiens_hsa002301.20779724
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20037229
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18938496
51GABAergic synapse_Homo sapiens_hsa047271.16386690
52mRNA surveillance pathway_Homo sapiens_hsa030151.15765962
53Arachidonic acid metabolism_Homo sapiens_hsa005901.13449514
54Glutamatergic synapse_Homo sapiens_hsa047241.12909477
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12872330
56Alzheimers disease_Homo sapiens_hsa050101.11931919
57Olfactory transduction_Homo sapiens_hsa047401.10751703
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07881915
59Collecting duct acid secretion_Homo sapiens_hsa049661.07716585
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07568419
61Morphine addiction_Homo sapiens_hsa050321.06412827
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.05592289
63ABC transporters_Homo sapiens_hsa020101.04208417
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03724498
65Peroxisome_Homo sapiens_hsa041461.02450928
66Fructose and mannose metabolism_Homo sapiens_hsa000511.02237538
67Mineral absorption_Homo sapiens_hsa049781.01940221
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01428748
69Synaptic vesicle cycle_Homo sapiens_hsa047211.00186826
70Chemical carcinogenesis_Homo sapiens_hsa052040.98722665
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97573235
72Insulin secretion_Homo sapiens_hsa049110.95498809
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.94316050
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92189418
75N-Glycan biosynthesis_Homo sapiens_hsa005100.92000069
76Cardiac muscle contraction_Homo sapiens_hsa042600.91764414
77Type I diabetes mellitus_Homo sapiens_hsa049400.91123381
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89696150
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88112420
80Salivary secretion_Homo sapiens_hsa049700.86829177
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83024872
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82603567
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82146578
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80627578
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.80396412
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79332558
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78216192
88Inositol phosphate metabolism_Homo sapiens_hsa005620.77358556
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75512536
90Sphingolipid metabolism_Homo sapiens_hsa006000.73812651
91Phototransduction_Homo sapiens_hsa047440.71887157
92PPAR signaling pathway_Homo sapiens_hsa033200.70286788
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70227247
94Retinol metabolism_Homo sapiens_hsa008300.69170814
95Antigen processing and presentation_Homo sapiens_hsa046120.66291106
96Legionellosis_Homo sapiens_hsa051340.65669755
97RNA transport_Homo sapiens_hsa030130.65642484
98cAMP signaling pathway_Homo sapiens_hsa040240.64608660
99Homologous recombination_Homo sapiens_hsa034400.63734260
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.62026689
101Asthma_Homo sapiens_hsa053100.61909976
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59302071
103Measles_Homo sapiens_hsa051620.57594916
104Cholinergic synapse_Homo sapiens_hsa047250.57142763
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.56654339
106Hedgehog signaling pathway_Homo sapiens_hsa043400.55723020
107One carbon pool by folate_Homo sapiens_hsa006700.55448640
108Estrogen signaling pathway_Homo sapiens_hsa049150.53928869
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53056514
110Gastric acid secretion_Homo sapiens_hsa049710.52739777
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52033709
112beta-Alanine metabolism_Homo sapiens_hsa004100.51232905
113Wnt signaling pathway_Homo sapiens_hsa043100.51026026
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49405240
115African trypanosomiasis_Homo sapiens_hsa051430.48630076
116Pancreatic secretion_Homo sapiens_hsa049720.47581952
117Hematopoietic cell lineage_Homo sapiens_hsa046400.45750798
118Autoimmune thyroid disease_Homo sapiens_hsa053200.45631838
119Metabolic pathways_Homo sapiens_hsa011000.44758649
120Rheumatoid arthritis_Homo sapiens_hsa053230.43546063
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42162726
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41925827
123Allograft rejection_Homo sapiens_hsa053300.41795144
124Influenza A_Homo sapiens_hsa051640.41212555
125Cocaine addiction_Homo sapiens_hsa050300.40532037
126Staphylococcus aureus infection_Homo sapiens_hsa051500.39912850
127Graft-versus-host disease_Homo sapiens_hsa053320.39826334
128Pyrimidine metabolism_Homo sapiens_hsa002400.39649808
129Dopaminergic synapse_Homo sapiens_hsa047280.39395355
130Serotonergic synapse_Homo sapiens_hsa047260.38534940
131Long-term depression_Homo sapiens_hsa047300.38461560
132Oxytocin signaling pathway_Homo sapiens_hsa049210.38156984
133Other glycan degradation_Homo sapiens_hsa005110.38073731
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37169330
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34197301
136Systemic lupus erythematosus_Homo sapiens_hsa053220.34002850
137Fat digestion and absorption_Homo sapiens_hsa049750.33814278
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.32874070
139B cell receptor signaling pathway_Homo sapiens_hsa046620.32509057
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32118043
141RNA degradation_Homo sapiens_hsa030180.30126106
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29616107
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29060826
144Endocytosis_Homo sapiens_hsa041440.28647241
145Renin-angiotensin system_Homo sapiens_hsa046140.27682853
146Basal cell carcinoma_Homo sapiens_hsa052170.27255552
147Ovarian steroidogenesis_Homo sapiens_hsa049130.26977725

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