SLC26A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)9.36926402
2chemical homeostasis within a tissue (GO:0048875)7.83189970
3detection of molecule of bacterial origin (GO:0032490)7.28829554
4auditory receptor cell stereocilium organization (GO:0060088)6.71562659
5cellular anion homeostasis (GO:0030002)6.69110977
6negative regulation of macroautophagy (GO:0016242)6.59271834
7trivalent inorganic anion homeostasis (GO:0072506)6.31543829
8phosphate ion homeostasis (GO:0055062)6.31543829
9positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.97153050
10energy homeostasis (GO:0097009)5.48665512
11bundle of His cell to Purkinje myocyte communication (GO:0086069)5.29869472
12sarcomere organization (GO:0045214)5.10811471
13keratinization (GO:0031424)5.06382132
14post-embryonic morphogenesis (GO:0009886)4.93822170
15detection of external biotic stimulus (GO:0098581)4.81390059
16cardiac myofibril assembly (GO:0055003)4.78474501
17maintenance of gastrointestinal epithelium (GO:0030277)4.65951152
18positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.56243888
19negative regulation of meiosis (GO:0045835)4.49064204
20ventricular cardiac muscle cell action potential (GO:0086005)4.47879330
21inner ear receptor stereocilium organization (GO:0060122)4.47423982
22cardiac muscle contraction (GO:0060048)4.43561744
23myofibril assembly (GO:0030239)4.41524568
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.33645220
25sarcoplasmic reticulum calcium ion transport (GO:0070296)4.33426192
26cardiac muscle hypertrophy (GO:0003300)4.33213977
27pattern specification involved in kidney development (GO:0061004)4.29931695
28establishment of skin barrier (GO:0061436)4.22379927
29actin-myosin filament sliding (GO:0033275)4.15591981
30muscle filament sliding (GO:0030049)4.15591981
31striated muscle hypertrophy (GO:0014897)4.06424257
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.02372364
33regulation of actin filament-based movement (GO:1903115)3.96149758
34positive regulation of neurological system process (GO:0031646)3.93083292
35detection of biotic stimulus (GO:0009595)3.92834825
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.91907858
37regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.83918466
38lateral ventricle development (GO:0021670)3.82768878
39regulation of water loss via skin (GO:0033561)3.78394717
40atrioventricular valve morphogenesis (GO:0003181)3.76468760
41prostate gland growth (GO:0060736)3.73817675
42muscle hypertrophy (GO:0014896)3.72408288
43regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.72368657
44forebrain neuron differentiation (GO:0021879)3.71898434
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.71545634
46cell communication involved in cardiac conduction (GO:0086065)3.67593872
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.65376248
48cardiac muscle tissue morphogenesis (GO:0055008)3.62208946
49regulation of cardioblast differentiation (GO:0051890)3.61491693
50actomyosin structure organization (GO:0031032)3.60335212
51positive regulation of cellular amide metabolic process (GO:0034250)3.56418303
52glycoside metabolic process (GO:0016137)3.55580355
53regulation of interleukin-6 biosynthetic process (GO:0045408)3.54510335
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42497609
55positive regulation of p38MAPK cascade (GO:1900745)3.41783834
56actin-mediated cell contraction (GO:0070252)3.40419974
57multicellular organismal water homeostasis (GO:0050891)3.37266821
58striated muscle contraction (GO:0006941)3.36299687
59neuron remodeling (GO:0016322)3.34307717
60regulation of sarcomere organization (GO:0060297)3.28506105
61negative regulation of complement activation (GO:0045916)3.25387784
62regulation of the force of heart contraction (GO:0002026)3.24785613
63negative regulation of potassium ion transmembrane transport (GO:1901380)3.24218895
64epithelial structure maintenance (GO:0010669)3.23337701
65muscle tissue morphogenesis (GO:0060415)3.22453432
66striated muscle atrophy (GO:0014891)3.20998599
67synaptic vesicle docking involved in exocytosis (GO:0016081)3.19985089
68positive regulation of neurotransmitter secretion (GO:0001956)3.19434069
69sphingosine metabolic process (GO:0006670)3.16705472
70negative regulation of response to extracellular stimulus (GO:0032105)3.14812586
71negative regulation of response to nutrient levels (GO:0032108)3.14812586
72regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12529522
73response to inactivity (GO:0014854)3.11324336
74skeletal muscle adaptation (GO:0043501)3.08955566
75regulation of striated muscle contraction (GO:0006942)3.08345064
76regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.05204335
77response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.04709754
78neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.04210649
79keratinocyte differentiation (GO:0030216)3.02951657
80negative regulation of protein localization to cell surface (GO:2000009)2.99027403
81regulation of relaxation of muscle (GO:1901077)2.98600137
82actin filament-based movement (GO:0030048)2.98253635
83negative regulation of meiotic cell cycle (GO:0051447)2.97222627
84positive regulation of uterine smooth muscle contraction (GO:0070474)2.96950598
85cardiac muscle adaptation (GO:0014887)2.96802449
86cardiac muscle hypertrophy in response to stress (GO:0014898)2.96802449
87muscle hypertrophy in response to stress (GO:0003299)2.96802449
88cardiac muscle cell action potential (GO:0086001)2.96615277
89mesenchymal cell differentiation involved in kidney development (GO:0072161)2.95885458
90mesenchymal cell differentiation involved in renal system development (GO:2001012)2.95885458
91regulation of p38MAPK cascade (GO:1900744)2.94763625
92regulation of activation of Janus kinase activity (GO:0010533)2.94190675
93cardiac muscle cell action potential involved in contraction (GO:0086002)2.94119028
94estrogen biosynthetic process (GO:0006703)2.92415716
95diol metabolic process (GO:0034311)2.91602685
96cellular response to epinephrine stimulus (GO:0071872)2.89954043
97positive regulation of vascular permeability (GO:0043117)2.89378815
98water homeostasis (GO:0030104)2.86047129
99muscle atrophy (GO:0014889)2.86028590
100striated muscle adaptation (GO:0014888)2.84698870
101negative regulation of protein activation cascade (GO:2000258)2.82783081
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.81532685
103exogenous drug catabolic process (GO:0042738)2.80685120
104adult heart development (GO:0007512)2.78337823
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77795684
106heart contraction (GO:0060047)2.77633402
107heart process (GO:0003015)2.77633402
108phosphatidylserine acyl-chain remodeling (GO:0036150)2.75879992
109phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.75823648
110cell proliferation involved in kidney development (GO:0072111)2.75689805
111positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.74390291
112regulation of heart rate (GO:0002027)2.73744228
113potassium ion export (GO:0071435)2.72105294
114negative regulation of mast cell activation (GO:0033004)2.71801336
115regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.71560888
116cardiac conduction (GO:0061337)2.70049488
117positive regulation of hormone biosynthetic process (GO:0046886)2.69750783
118relaxation of cardiac muscle (GO:0055119)2.68588501
119regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.66819477
120cell communication by electrical coupling (GO:0010644)2.64871213
121regulation of cardiac muscle contraction (GO:0055117)2.64684824
122peptide cross-linking (GO:0018149)2.63583955
123response to epinephrine (GO:0071871)2.63574074
124sphingoid metabolic process (GO:0046519)2.63110610
125response to caffeine (GO:0031000)2.62158830
126regulation of membrane protein ectodomain proteolysis (GO:0051043)2.61559546
127muscle adaptation (GO:0043500)2.61500318
128endocardial cushion development (GO:0003197)2.61279717
129regulation of cell communication by electrical coupling (GO:0010649)2.60785702
130regulation of cardiac muscle cell contraction (GO:0086004)2.60780205
131cellular response to reactive nitrogen species (GO:1902170)2.60268037
132regulation of heart contraction (GO:0008016)2.60057694
133macrophage activation (GO:0042116)2.59529584
134positive regulation of CREB transcription factor activity (GO:0032793)2.58116476
135negative regulation of systemic arterial blood pressure (GO:0003085)2.57258635
136regulation of integrin-mediated signaling pathway (GO:2001044)2.56705582
137mesenchymal cell proliferation (GO:0010463)2.56146281
138regulation of membrane repolarization (GO:0060306)2.55366875
139negative regulation of cell fate specification (GO:0009996)2.52223474
140negative regulation of humoral immune response (GO:0002921)2.52051451
141regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50232514
142positive regulation of protein kinase C signaling (GO:0090037)2.49685147
143detection of calcium ion (GO:0005513)2.49407200
144ganglion development (GO:0061548)2.49300262
145negative regulation of myotube differentiation (GO:0010832)2.48728475
146epidermal cell differentiation (GO:0009913)2.48574378
147regulation of necroptotic process (GO:0060544)2.47696910
148negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47132253
149regulation of heart rate by cardiac conduction (GO:0086091)2.46671414
150lung secretory cell differentiation (GO:0061140)2.46181427
151somatic stem cell division (GO:0048103)2.45963259
152negative regulation of alcohol biosynthetic process (GO:1902931)2.42727686
153germinal center formation (GO:0002467)2.39765026
154vocalization behavior (GO:0071625)2.38079314
155negative regulation of glial cell proliferation (GO:0060253)2.35518556
156lung lobe morphogenesis (GO:0060463)2.34834747
157opioid receptor signaling pathway (GO:0038003)2.32337568
158positive regulation of protein sumoylation (GO:0033235)2.30874953
159pigment granule localization (GO:0051875)2.29239283
160positive regulation of histone acetylation (GO:0035066)2.29067910
161columnar/cuboidal epithelial cell development (GO:0002066)2.28684587
162cell proliferation involved in metanephros development (GO:0072203)2.28363210
163mesonephros development (GO:0001823)2.27700318
164positive regulation of neurotransmitter transport (GO:0051590)2.27368063
165drug catabolic process (GO:0042737)2.26350078
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25483654
167positive regulation of protein homooligomerization (GO:0032464)2.23711032
168response to pheromone (GO:0019236)2.23263711
169mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.22935707
170O-glycan processing (GO:0016266)2.22601215
171regulation of phospholipid biosynthetic process (GO:0071071)2.21776363
172negative regulation of keratinocyte proliferation (GO:0010839)2.20842733
173positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18269321
174positive regulation of endothelial cell differentiation (GO:0045603)2.17155179
175tachykinin receptor signaling pathway (GO:0007217)2.15541412
176branch elongation of an epithelium (GO:0060602)2.15133724
177negative regulation of autophagy (GO:0010507)2.14053471
178regulation of phospholipase A2 activity (GO:0032429)2.13264953
179regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12926309
180negative regulation of stem cell proliferation (GO:2000647)2.12684946
181regulation of glomerular filtration (GO:0003093)2.11732594
182pigment granule transport (GO:0051904)2.10892480
183regulation of chemokine secretion (GO:0090196)2.10314675
184regulation of glial cell proliferation (GO:0060251)2.10133410
185regulation of meiosis (GO:0040020)2.09896778
186desmosome organization (GO:0002934)2.09404647
187motile cilium assembly (GO:0044458)2.08411912
188venous blood vessel morphogenesis (GO:0048845)2.08118179
189regulation of uterine smooth muscle contraction (GO:0070472)2.07636096
190sodium-independent organic anion transport (GO:0043252)2.06249204
191embryonic camera-type eye morphogenesis (GO:0048596)2.03793209
192eye photoreceptor cell development (GO:0042462)2.03708291
193polyketide metabolic process (GO:0030638)18.3196669
194doxorubicin metabolic process (GO:0044598)18.3196669
195daunorubicin metabolic process (GO:0044597)18.3196669
196aminoglycoside antibiotic metabolic process (GO:0030647)11.7759074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.36820400
2GBX2_23144817_ChIP-Seq_PC3_Human3.22098194
3EZH2_22144423_ChIP-Seq_EOC_Human3.16513553
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.10263470
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.04895247
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.92636672
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71362322
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.45445647
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35930968
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.18253760
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.16494064
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.04916134
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03566003
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97833458
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97833458
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.95363516
17TBX20_22080862_ChIP-Seq_HEART_Mouse1.95363516
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94058454
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89291171
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87718112
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.86998471
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85609800
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81061063
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80078558
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.79790571
26RXR_22108803_ChIP-Seq_LS180_Human1.79440520
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.78009641
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77941623
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.74421837
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.74310937
31NFIB_24661679_ChIP-Seq_LUNG_Mouse1.72966861
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72822338
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70651643
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70473477
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.66368124
36VDR_22108803_ChIP-Seq_LS180_Human1.65166361
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.61069878
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60984483
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57812301
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.57720527
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57673609
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57060641
43P300_19829295_ChIP-Seq_ESCs_Human1.57039044
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56957202
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.54805412
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.53935387
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53656417
48DROSHA_22980978_ChIP-Seq_HELA_Human1.53473869
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53048067
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52354290
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51712340
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.51576994
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.51274948
54IGF1R_20145208_ChIP-Seq_DFB_Human1.49868228
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.46715049
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45615024
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45038131
58SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44902680
59AHR_22903824_ChIP-Seq_MCF-7_Human1.43027659
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42619778
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39970883
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.39382619
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38104888
64RNF2_27304074_Chip-Seq_NSC_Mouse1.37321292
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36917633
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.35847402
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35773848
68FOXO3_23340844_ChIP-Seq_DLD1_Human1.34836772
69TP53_18474530_ChIP-ChIP_U2OS_Human1.34316197
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34246680
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33900537
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31746321
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.31069463
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30764972
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29946771
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29580980
77SMAD4_21799915_ChIP-Seq_A2780_Human1.29386226
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29000519
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28886689
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27692001
81* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27689157
82* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27326089
83GATA1_22025678_ChIP-Seq_K562_Human1.26513568
84CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25695287
85RUNX2_22187159_ChIP-Seq_PCA_Human1.25347266
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24668494
87SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24046216
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24046216
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23169333
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.22958857
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21279198
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.20860097
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.20562086
94AR_25329375_ChIP-Seq_VCAP_Human1.20495175
95* NFE2_27457419_Chip-Seq_LIVER_Mouse1.18303190
96* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17414279
97* EZH2_27294783_Chip-Seq_NPCs_Mouse1.17360997
98* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15779806
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15725641
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15645164
101EP300_21415370_ChIP-Seq_HL-1_Mouse1.15548778
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14598145
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.14049561
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13686461
105* E2F1_18555785_Chip-Seq_ESCs_Mouse1.13015779
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12571658
107* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12426276
108IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12070059
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11099265
110CJUN_26792858_Chip-Seq_BT549_Human1.10173612
111SOX2_20726797_ChIP-Seq_SW620_Human1.09064068
112VDR_24787735_ChIP-Seq_THP-1_Human1.09017176
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.07396607
114* STAT3_23295773_ChIP-Seq_U87_Human1.07335466
115RACK7_27058665_Chip-Seq_MCF-7_Human1.06883890
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06481330
117* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06146593
118* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06028671
119VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05451036
120* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04641403
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04045261
122* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04029876
123TCF4_22108803_ChIP-Seq_LS180_Human1.03862364
124* P53_22387025_ChIP-Seq_ESCs_Mouse1.03701089
125TCF4_23295773_ChIP-Seq_U87_Human1.03551926
126GATA2_21666600_ChIP-Seq_HMVEC_Human1.03438979
127CLOCK_20551151_ChIP-Seq_293T_Human1.02987476
128CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02804044
129OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02691379
130KDM2B_26808549_Chip-Seq_REH_Human1.01521704
131RING1B_27294783_Chip-Seq_ESCs_Mouse1.01011674
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00083186
133* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99824351
134* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99303814
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99118622
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99118622
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.99002409
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98454478
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97955867
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97859377
141KLF5_25053715_ChIP-Seq_YYC3_Human0.97715184
142* GATA4_25053715_ChIP-Seq_YYC3_Human0.95424160
143* SOX2_18555785_Chip-Seq_ESCs_Mouse0.95370630
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94953970
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94927509
146ER_23166858_ChIP-Seq_MCF-7_Human0.94620798
147* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94282753
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93045675
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92752607
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92125013
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90194582
152* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87691327
153TP63_23658742_ChIP-Seq_EP156T_Human0.85793298
154KDM2B_26808549_Chip-Seq_K562_Human0.84935202
155* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83566725
156TP63_22573176_ChIP-Seq_HFKS_Human0.83558637
157IRF8_27001747_Chip-Seq_BMDM_Mouse0.83509250
158THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83341225
159MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83127761
160* GATA6_25053715_ChIP-Seq_YYC3_Human0.82895188
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82658134
162* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82281360
163RXR_22158963_ChIP-Seq_LIVER_Mouse0.80957465
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80398932
165TP53_16413492_ChIP-PET_HCT116_Human0.79179852
166SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78734995
167RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77069173
168* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76726712
169LXR_22292898_ChIP-Seq_THP-1_Human0.76399003
170GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76247818
171* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76247109
172GATA1_19941826_ChIP-Seq_K562_Human0.76126703
173SPI1_23127762_ChIP-Seq_K562_Human0.76038024
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75640338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.63203106
2MP0003878_abnormal_ear_physiology6.19071523
3MP0005377_hearing/vestibular/ear_phenot6.19071523
4MP0004084_abnormal_cardiac_muscle4.90520308
5* MP0008004_abnormal_stomach_pH4.61061464
6MP0000566_synostosis4.36223920
7MP0004510_myositis3.74800146
8MP0002837_dystrophic_cardiac_calcinosis3.57960848
9MP0005645_abnormal_hypothalamus_physiol3.47602486
10MP0004215_abnormal_myocardial_fiber3.38905300
11MP0004036_abnormal_muscle_relaxation3.26075361
12MP0005275_abnormal_skin_tensile3.22028383
13MP0008995_early_reproductive_senescence3.17655367
14MP0000678_abnormal_parathyroid_gland3.15687252
15MP0003879_abnormal_hair_cell2.87515414
16MP0000751_myopathy2.73107363
17MP0005083_abnormal_biliary_tract2.60653074
18MP0001485_abnormal_pinna_reflex2.55920296
19MP0005330_cardiomyopathy2.55532092
20MP0009697_abnormal_copulation2.49257078
21MP0004742_abnormal_vestibular_system2.48612709
22MP0006292_abnormal_olfactory_placode2.31138277
23MP0002972_abnormal_cardiac_muscle2.15104921
24MP0002277_abnormal_respiratory_mucosa2.05273649
25MP0001958_emphysema2.02934367
26MP0004484_altered_response_of2.00460277
27MP0003303_peritoneal_inflammation1.98995944
28MP0008775_abnormal_heart_ventricle1.98612682
29MP0003941_abnormal_skin_development1.96508598
30MP0006138_congestive_heart_failure1.95996905
31MP0001177_atelectasis1.93519324
32MP0003137_abnormal_impulse_conducting1.92825642
33MP0002132_abnormal_respiratory_system1.88779007
34MP0002098_abnormal_vibrissa_morphology1.83531643
35MP0004087_abnormal_muscle_fiber1.82587701
36MP0005165_increased_susceptibility_to1.82472730
37MP0000013_abnormal_adipose_tissue1.81867978
38MP0001346_abnormal_lacrimal_gland1.79819182
39MP0010630_abnormal_cardiac_muscle1.77441156
40MP0002332_abnormal_exercise_endurance1.74416355
41MP0003300_gastrointestinal_ulcer1.70225576
42MP0003828_pulmonary_edema1.68898919
43MP0005670_abnormal_white_adipose1.64298023
44MP0003724_increased_susceptibility_to1.63535471
45* MP0001664_abnormal_digestion1.62286583
46MP0009840_abnormal_foam_cell1.62109454
47MP0005620_abnormal_muscle_contractility1.62100581
48MP0004085_abnormal_heartbeat1.61744282
49MP0000681_abnormal_thyroid_gland1.60534240
50MP0005646_abnormal_pituitary_gland1.56330437
51MP0000749_muscle_degeneration1.56271015
52MP0000343_altered_response_to1.55626523
53* MP0000470_abnormal_stomach_morphology1.50275843
54MP0005385_cardiovascular_system_phenoty1.49893394
55MP0001544_abnormal_cardiovascular_syste1.49893394
56MP0010386_abnormal_urinary_bladder1.49356802
57MP0004947_skin_inflammation1.39865584
58MP0005451_abnormal_body_composition1.39713413
59MP0000579_abnormal_nail_morphology1.39576813
60MP0002102_abnormal_ear_morphology1.37726590
61MP0002133_abnormal_respiratory_system1.33653085
62MP0005388_respiratory_system_phenotype1.33653085
63MP0000003_abnormal_adipose_tissue1.30806517
64MP0001986_abnormal_taste_sensitivity1.29254191
65MP0003091_abnormal_cell_migration1.28829530
66MP0010234_abnormal_vibrissa_follicle1.28757352
67MP0005248_abnormal_Harderian_gland1.28149329
68MP0002796_impaired_skin_barrier1.27482204
69MP0005367_renal/urinary_system_phenotyp1.26797419
70MP0000516_abnormal_urinary_system1.26797419
71MP0005375_adipose_tissue_phenotype1.26517379
72MP0005666_abnormal_adipose_tissue1.26100432
73MP0008438_abnormal_cutaneous_collagen1.24728328
74MP0005647_abnormal_sex_gland1.20966729
75MP0005023_abnormal_wound_healing1.19265772
76MP0002127_abnormal_cardiovascular_syste1.18599351
77MP0002735_abnormal_chemical_nociception1.17397466
78MP0003279_aneurysm1.17154947
79MP0003705_abnormal_hypodermis_morpholog1.16560774
80MP0000747_muscle_weakness1.15586641
81MP0001440_abnormal_grooming_behavior1.14338533
82MP0003191_abnormal_cellular_cholesterol1.12869245
83MP0002106_abnormal_muscle_physiology1.11345154
84MP0002269_muscular_atrophy1.10575932
85MP0006276_abnormal_autonomic_nervous1.10561607
86MP0005423_abnormal_somatic_nervous1.10105847
87MP0000383_abnormal_hair_follicle1.07423804
88MP0005310_abnormal_salivary_gland1.06535098
89MP0004043_abnormal_pH_regulation1.04364015
90MP0003646_muscle_fatigue1.01638791
91MP0010368_abnormal_lymphatic_system1.00805938
92MP0002557_abnormal_social/conspecific_i0.96346143
93MP0002060_abnormal_skin_morphology0.96137918
94MP0010352_gastrointestinal_tract_polyps0.95693420
95MP0000627_abnormal_mammary_gland0.95382144
96MP0003786_premature_aging0.94079630
97MP0005369_muscle_phenotype0.92853747
98MP0003950_abnormal_plasma_membrane0.92490446
99MP0002249_abnormal_larynx_morphology0.91332264
100MP0005257_abnormal_intraocular_pressure0.90894618
101MP0004130_abnormal_muscle_cell0.90538117
102MP0005164_abnormal_response_to0.88495555
103MP0004145_abnormal_muscle_electrophysio0.87585447
104MP0001216_abnormal_epidermal_layer0.86775980
105MP0002138_abnormal_hepatobiliary_system0.85877351
106MP0003453_abnormal_keratinocyte_physiol0.84630991
107MP0001919_abnormal_reproductive_system0.83332979
108MP0000750_abnormal_muscle_regeneration0.82635584
109MP0002933_joint_inflammation0.82007461
110MP0005503_abnormal_tendon_morphology0.81766546
111MP0000759_abnormal_skeletal_muscle0.80497934
112MP0000767_abnormal_smooth_muscle0.80455465
113MP0002295_abnormal_pulmonary_circulatio0.80380524
114MP0005166_decreased_susceptibility_to0.80278852
115MP0001486_abnormal_startle_reflex0.80258708
116MP0001545_abnormal_hematopoietic_system0.78709387
117MP0005397_hematopoietic_system_phenotyp0.78709387
118MP0001542_abnormal_bone_strength0.78590086
119MP0000762_abnormal_tongue_morphology0.78158661
120MP0010155_abnormal_intestine_physiology0.78109457
121MP0001881_abnormal_mammary_gland0.77598364
122MP0010678_abnormal_skin_adnexa0.77013334
123MP0009278_abnormal_bone_marrow0.76209873
124MP0001501_abnormal_sleep_pattern0.75746751
125MP0003436_decreased_susceptibility_to0.75593885
126MP0000249_abnormal_blood_vessel0.74892806
127MP0002938_white_spotting0.74628480
128MP0000631_abnormal_neuroendocrine_gland0.74156591
129MP0002148_abnormal_hypersensitivity_rea0.74143508
130MP0009785_altered_susceptibility_to0.73700516
131MP0001502_abnormal_circadian_rhythm0.73419522
132MP0000639_abnormal_adrenal_gland0.71345201
133MP0005076_abnormal_cell_differentiation0.71298726
134MP0004858_abnormal_nervous_system0.69462535
135MP0002877_abnormal_melanocyte_morpholog0.69194976
136MP0003690_abnormal_glial_cell0.69073446
137MP0001175_abnormal_lung_morphology0.68775198
138MP0004264_abnormal_extraembryonic_tissu0.68268225
139MP0005595_abnormal_vascular_smooth0.68096618
140MP0005025_abnormal_response_to0.67978720
141MP0000026_abnormal_inner_ear0.67935339
142MP0002638_abnormal_pupillary_reflex0.67838278
143MP0005058_abnormal_lysosome_morphology0.66395027
144MP0001963_abnormal_hearing_physiology0.66372754
145MP0003566_abnormal_cell_adhesion0.65902945
146MP0003045_fibrosis0.65238002
147MP0003868_abnormal_feces_composition0.64946058
148MP0004885_abnormal_endolymph0.64768251
149MP0005501_abnormal_skin_physiology0.64020114
150MP0003937_abnormal_limbs/digits/tail_de0.60947438
151MP0003890_abnormal_embryonic-extraembry0.60689953
152MP0001879_abnormal_lymphatic_vessel0.57882858
153MP0002233_abnormal_nose_morphology0.57390729
154MP0001324_abnormal_eye_pigmentation0.57064207
155MP0000537_abnormal_urethra_morphology0.56402859
156MP0001293_anophthalmia0.55834100
157MP0003936_abnormal_reproductive_system0.54894073
158MP0000613_abnormal_salivary_gland0.54623116
159MP0002736_abnormal_nociception_after0.53931730
160MP0001851_eye_inflammation0.53923771
161MP0001790_abnormal_immune_system0.53642747
162MP0005387_immune_system_phenotype0.53642747
163MP0009764_decreased_sensitivity_to0.53587128
164MP0001119_abnormal_female_reproductive0.53041694
165MP0005389_reproductive_system_phenotype0.53024335
166MP0004883_abnormal_blood_vessel0.52732380
167MP0001968_abnormal_touch/_nociception0.52708240
168MP0005167_abnormal_blood-brain_barrier0.51764440
169MP0000534_abnormal_ureter_morphology0.50922732
170MP0001666_abnormal_nutrient_absorption0.50657836
171MP0005171_absent_coat_pigmentation0.50644364
172MP0003385_abnormal_body_wall0.48729189
173MP0002998_abnormal_bone_remodeling0.48491956

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)8.41709298
2Unilateral renal agenesis (HP:0000122)7.40822481
3Alopecia of scalp (HP:0002293)7.32260160
4Right ventricular cardiomyopathy (HP:0011663)7.13618301
5Sudden death (HP:0001699)6.52816441
6Follicular hyperkeratosis (HP:0007502)6.49575209
7Bilateral sensorineural hearing impairment (HP:0008619)6.39713910
8Interstitial pulmonary disease (HP:0006530)5.85574712
9Absent eyebrow (HP:0002223)5.73504223
10Abnormality of dental color (HP:0011073)5.71251104
11Ventricular tachycardia (HP:0004756)5.53121407
12Recurrent corneal erosions (HP:0000495)5.08399633
13Chronic otitis media (HP:0000389)5.01471574
14Absent eyelashes (HP:0000561)4.99216564
15Absent/shortened dynein arms (HP:0200106)4.98970648
16Dynein arm defect of respiratory motile cilia (HP:0012255)4.98970648
17Bundle branch block (HP:0011710)4.97124881
18Atrial fibrillation (HP:0005110)4.88744233
19Syncope (HP:0001279)4.74031182
20Cheilitis (HP:0100825)4.58060841
21Primary atrial arrhythmia (HP:0001692)4.42989778
22Hyporeflexia of lower limbs (HP:0002600)4.21901485
23Supraventricular tachycardia (HP:0004755)4.20246877
24Increased IgE level (HP:0003212)4.18782412
25Tetany (HP:0001281)4.14632923
26Hyperactive renin-angiotensin system (HP:0000841)4.08377547
27Supraventricular arrhythmia (HP:0005115)4.07992548
28Hyperphosphatemia (HP:0002905)4.05649675
29Abolished electroretinogram (ERG) (HP:0000550)3.83296546
30Ventricular fibrillation (HP:0001663)3.82144505
31Abnormality of nail color (HP:0100643)3.81917767
32Tubulointerstitial fibrosis (HP:0005576)3.77280551
33Ventricular arrhythmia (HP:0004308)3.76241716
34Muscle fiber splitting (HP:0003555)3.75444774
35Abnormal ciliary motility (HP:0012262)3.73041756
36Asymmetric septal hypertrophy (HP:0001670)3.67221420
37Distal lower limb muscle weakness (HP:0009053)3.58873269
38Lipoatrophy (HP:0100578)3.52158863
39Dilated cardiomyopathy (HP:0001644)3.45432380
40Ectropion (HP:0000656)3.44560220
41Erythroderma (HP:0001019)3.27269825
42Tubulointerstitial nephritis (HP:0001970)3.23020384
43Renal dysplasia (HP:0000110)3.19293328
44Abnormality of the fingertips (HP:0001211)3.13997737
45Heart block (HP:0012722)3.11925043
46Abnormal atrioventricular conduction (HP:0005150)3.11247323
47Exercise-induced myalgia (HP:0003738)3.10272458
48Congenital sensorineural hearing impairment (HP:0008527)3.08035289
49Blepharitis (HP:0000498)3.06018822
50Palmoplantar keratoderma (HP:0000982)3.04684082
51Abnormal respiratory motile cilium morphology (HP:0005938)3.04578741
52Abnormal respiratory epithelium morphology (HP:0012253)3.04578741
53Abnormal respiratory motile cilium physiology (HP:0012261)3.01769299
54Systemic lupus erythematosus (HP:0002725)2.85834011
55Plantar hyperkeratosis (HP:0007556)2.83687185
56Respiratory distress (HP:0002098)2.83086806
57Atrioventricular block (HP:0001678)2.78463169
58Abnormality of the calf musculature (HP:0001430)2.74537878
59Prolonged QT interval (HP:0001657)2.73520762
60Palmoplantar hyperkeratosis (HP:0000972)2.70998232
61Corneal erosion (HP:0200020)2.70019849
62Onycholysis (HP:0001806)2.69695607
63Abnormality of incisor morphology (HP:0011063)2.68320453
64Rhinitis (HP:0012384)2.67492228
65Tachypnea (HP:0002789)2.67096115
66Chronic hepatic failure (HP:0100626)2.63192025
67Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.62831287
68Complement deficiency (HP:0004431)2.62667747
69Tubulointerstitial abnormality (HP:0001969)2.62509659
70Distal lower limb amyotrophy (HP:0008944)2.62096053
71EMG: myopathic abnormalities (HP:0003458)2.61815277
72Absent hair (HP:0002298)2.58916617
73Neoplasm of the lung (HP:0100526)2.56416176
74Palmar hyperkeratosis (HP:0010765)2.55708351
75Chronic sinusitis (HP:0011109)2.55613777
76Glomerulonephritis (HP:0000099)2.54193564
77Centrally nucleated skeletal muscle fibers (HP:0003687)2.51606724
78Hyperaldosteronism (HP:0000859)2.47492589
79Abnormality of chloride homeostasis (HP:0011422)2.46301594
80Increased connective tissue (HP:0009025)2.46167993
81EMG: neuropathic changes (HP:0003445)2.40825040
82Nuclear cataract (HP:0100018)2.39975626
83Thyroid-stimulating hormone excess (HP:0002925)2.35444687
84Keratitis (HP:0000491)2.33740674
85Sudden cardiac death (HP:0001645)2.31819338
86Tubular atrophy (HP:0000092)2.28508879
87Congenital ichthyosiform erythroderma (HP:0007431)2.26285887
88Abnormal EKG (HP:0003115)2.24353549
89Hyperkalemia (HP:0002153)2.21146096
90Abnormality of renin-angiotensin system (HP:0000847)2.20575592
91Osteomalacia (HP:0002749)2.20287586
92Amelogenesis imperfecta (HP:0000705)2.17425213
93Mildly elevated creatine phosphokinase (HP:0008180)2.16747767
94Dysmetric saccades (HP:0000641)2.15946409
95Cerebral aneurysm (HP:0004944)2.15584320
96Renal salt wasting (HP:0000127)2.14475961
97Septo-optic dysplasia (HP:0100842)2.10771077
98Neoplasm of the respiratory system (HP:0100606)2.10309863
99Abnormality of complement system (HP:0005339)2.09160573
100Chronic bronchitis (HP:0004469)2.07801726
101Aneurysm (HP:0002617)2.07665996
102Abnormality of the left ventricular outflow tract (HP:0011103)2.07351229
103Subaortic stenosis (HP:0001682)2.07351229
104Neck muscle weakness (HP:0000467)2.06372517
105Conical tooth (HP:0000698)2.05999531
106Type 1 muscle fiber predominance (HP:0003803)2.05623226
107Ulnar bowing (HP:0003031)2.05454971
108Palpitations (HP:0001962)2.03154426
109Abnormality of the right ventricle (HP:0001707)2.02238068
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01923282
111Gangrene (HP:0100758)2.01512546
112Calf muscle hypertrophy (HP:0008981)1.99499623
113Malnutrition (HP:0004395)1.98881339
114Lower limb amyotrophy (HP:0007210)1.98853487
115Abnormality of calcium-phosphate metabolism (HP:0100530)1.97689117
116Genetic anticipation (HP:0003743)1.96365801
117Hypergonadotropic hypogonadism (HP:0000815)1.95137024
118Abnormality of the renal collecting system (HP:0004742)1.94530082
119Bile duct proliferation (HP:0001408)1.93142844
120Abnormal biliary tract physiology (HP:0012439)1.93142844
121Ectopic kidney (HP:0000086)1.91520701
122Abnormality of the salivary glands (HP:0010286)1.91210808
123Thick nail (HP:0001805)1.90758448
124Renal agenesis (HP:0000104)1.90318002
125Gout (HP:0001997)1.89879914
126Frequent falls (HP:0002359)1.88515964
127Duplicated collecting system (HP:0000081)1.87853470
128Lip pit (HP:0100267)1.86251422
129Abnormality of the renal cortex (HP:0011035)1.85348741
130Axonal loss (HP:0003447)1.82721663
131Abnormality of the foot musculature (HP:0001436)1.82597596
132Aortic aneurysm (HP:0004942)1.82052899
133Plagiocephaly (HP:0001357)1.81989892
134Erythema (HP:0010783)1.81206123
135Muscle hypertrophy of the lower extremities (HP:0008968)1.80010186
136Hypergammaglobulinemia (HP:0010702)1.79482754
137Vertigo (HP:0002321)1.79293730
138Corneal dystrophy (HP:0001131)1.77004226
139Chromsome breakage (HP:0040012)1.76354986
140Difficulty climbing stairs (HP:0003551)1.74715228
141Foot dorsiflexor weakness (HP:0009027)1.72705775
142Sparse eyelashes (HP:0000653)1.72510497
143Hypohidrosis (HP:0000966)1.71633320
144Nephritis (HP:0000123)1.71541587
145Skin nodule (HP:0200036)1.70563654
146Alveolar cell carcinoma (HP:0006519)1.70181472
147Mitral stenosis (HP:0001718)1.68416810
148Vertebral arch anomaly (HP:0008438)1.68067080
149Abnormality of the ischium (HP:0003174)1.67377716
150True hermaphroditism (HP:0010459)1.66702725
151Melanoma (HP:0002861)1.66031276
152Prostate neoplasm (HP:0100787)1.65644145
153Thin bony cortex (HP:0002753)1.65512646
154Proximal amyotrophy (HP:0007126)1.65329627
155Bradycardia (HP:0001662)1.65249503
156Retrobulbar optic neuritis (HP:0100654)1.64613002
157Optic neuritis (HP:0100653)1.64613002
158Bronchiectasis (HP:0002110)1.62435757
159Stomach cancer (HP:0012126)1.62081000
160Left ventricular hypertrophy (HP:0001712)1.62078597
161Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.62014185
162Hypoparathyroidism (HP:0000829)1.61628591
163Wormian bones (HP:0002645)1.61387107
164Aplasia cutis congenita (HP:0001057)1.59326367
165Muscle fiber inclusion bodies (HP:0100299)1.58494921
166Pulmonary hypertension (HP:0002092)1.58363245
167Oligohydramnios (HP:0001562)1.58335088
168Difficulty walking (HP:0002355)1.56643267
169Urticaria (HP:0001025)1.54129696
170Neoplasm of the tracheobronchial system (HP:0100552)1.53810997
171Abnormality of the renal medulla (HP:0100957)1.52798172
172Nail dystrophy (HP:0008404)1.52764956
173Pancreatic fibrosis (HP:0100732)1.51620029
174Barrel-shaped chest (HP:0001552)1.51300620
175Hypocalcemia (HP:0002901)1.51256390
176Progressive sensorineural hearing impairment (HP:0000408)1.50515581
177Absent septum pellucidum (HP:0001331)1.48162805
178White forelock (HP:0002211)1.46585903
179Abnormality of renal excretion (HP:0011036)1.44704094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK38.85588897
2EPHA24.82709830
3SIK14.69709181
4SIK24.32939907
5LMTK23.70372830
6LATS13.40376005
7OBSCN3.19471661
8TTN2.88281894
9CDC42BPA2.83258685
10DMPK2.57048779
11PAK42.52165620
12STK38L2.48379000
13STK242.41011455
14MAP3K122.34810827
15MARK32.29353762
16PRPF4B2.02943885
17CASK1.81583616
18MET1.73418382
19CDK81.68575416
20CDK121.55595584
21DDR21.51454515
22FGFR41.50270930
23TIE11.46359742
24TAOK31.40287065
25MAP3K71.35421079
26ROCK11.31099517
27ADRBK21.30483734
28MAP3K141.29250271
29ICK1.25873838
30INSRR1.23882105
31TRIB31.22720783
32TXK1.21602509
33ERN11.16435084
34TBK11.16296735
35MARK21.12053135
36LATS21.10436487
37BMPR21.08269734
38MST41.07916967
39FGFR31.06418891
40SGK21.05600656
41PDGFRA1.05226210
42PRKD11.01053172
43FGFR20.99770783
44ZAP700.99625863
45TAOK10.99096246
46JAK10.95674003
47BMPR1B0.95556480
48MAPKAPK30.95433922
49STK30.91284269
50MAPK130.91248111
51MAP2K70.86998050
52MUSK0.86993659
53PHKG10.85067829
54PHKG20.85067829
55EPHB20.84218030
56PDK20.82687376
57FER0.80541710
58BLK0.79903291
59IRAK40.79704554
60DAPK30.79210133
61TEC0.76626631
62PRKAA10.76485156
63MKNK20.76406451
64CAMK1G0.76404228
65CAMK1D0.75459204
66MAPK70.75404977
67TLK10.73375973
68EPHB10.72378219
69PKN20.71916080
70MST1R0.71637106
71WNK10.70823929
72NLK0.69727500
73MTOR0.69678123
74TNIK0.66991421
75PAK30.65988370
76STK380.63741094
77HIPK20.63720867
78STK100.62462852
79SGK30.59840995
80ERBB40.59640168
81MAPK120.58993501
82PTK20.58672381
83EPHA30.58445223
84PIK3CG0.57826110
85YES10.57824167
86SGK4940.57309754
87SGK2230.57309754
88MELK0.57092961
89ZAK0.56784113
90PDPK10.56781220
91PRKG20.56648702
92EPHA40.56417312
93TYK20.55608156
94GRK10.55411329
95NUAK10.55029909
96FRK0.55028597
97CAMK10.54177829
98RPS6KA20.54077589
99BMX0.53714951
100CAMK2D0.53193744
101TAOK20.53007914
102STK390.52758678
103PDGFRB0.52514753
104MAPK150.51420861
105CSNK1A1L0.50405675
106PKN10.48533542
107TRPM70.47696136
108PRKCE0.47530165
109MAPK40.46860755
110BCR0.45142154
111CSNK1D0.43703818
112PIK3CA0.42666942
113IRAK30.42461349
114IKBKB0.41707832
115DAPK20.41006577
116IKBKE0.40015831
117JAK30.39663463
118MAP3K60.39388422
119CDK30.38854744
120TGFBR20.37615348
121CHUK0.33702934
122PRKAA20.33439505
123GRK70.32955953
124PRKCQ0.32574684
125ERBB20.32085135
126SRPK10.30818397
127MAP3K30.30619579
128RIPK40.29290317
129MAP2K40.28697245
130RPS6KL10.26669644
131RPS6KC10.26669644
132MAP3K50.26435975
133NEK60.26046020
134MAP2K20.25739710
135CAMK40.25631218
136RPS6KA60.25126179
137IRAK10.25045747
138MYLK0.24188172
139VRK10.22074308
140SGK10.21699762
141NEK90.20770041
142CSNK1G30.20343195
143MAP3K20.20031710
144MAP2K60.18873691
145AKT30.18409615
146IRAK20.17009841
147CSNK1G10.16542564
148CSNK1G20.16374428
149RIPK10.15655595
150EIF2AK20.14725520
151PRKG10.14684936
152RPS6KA40.14671032
153ADRBK10.13824753

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049662.71334357
2Ether lipid metabolism_Homo sapiens_hsa005652.02342279
3Nicotine addiction_Homo sapiens_hsa050331.91595965
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90950204
5* Mineral absorption_Homo sapiens_hsa049781.89337507
6Gastric acid secretion_Homo sapiens_hsa049711.85987183
7Circadian rhythm_Homo sapiens_hsa047101.71367415
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69127734
9Ovarian steroidogenesis_Homo sapiens_hsa049131.61477377
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61208644
11Cardiac muscle contraction_Homo sapiens_hsa042601.59311702
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.52722398
13Taste transduction_Homo sapiens_hsa047421.51472903
14Amoebiasis_Homo sapiens_hsa051461.48639132
15Axon guidance_Homo sapiens_hsa043601.47865062
16Rheumatoid arthritis_Homo sapiens_hsa053231.45648800
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.45496501
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44835444
19Complement and coagulation cascades_Homo sapiens_hsa046101.42880311
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39807007
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36447133
22Adherens junction_Homo sapiens_hsa045201.36351733
23Melanoma_Homo sapiens_hsa052181.35799338
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34882016
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34212419
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31602275
27Sphingolipid metabolism_Homo sapiens_hsa006001.31078910
28Phagosome_Homo sapiens_hsa041451.30149784
29Chemical carcinogenesis_Homo sapiens_hsa052041.30009895
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.29758500
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25895527
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25753611
33Other glycan degradation_Homo sapiens_hsa005111.23859684
34Linoleic acid metabolism_Homo sapiens_hsa005911.23810780
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.21934960
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20207941
37Hematopoietic cell lineage_Homo sapiens_hsa046401.15125000
38Serotonergic synapse_Homo sapiens_hsa047261.13746964
39ABC transporters_Homo sapiens_hsa020101.10247908
40ECM-receptor interaction_Homo sapiens_hsa045121.07415680
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07190590
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07008347
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06724198
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05892411
45Renal cell carcinoma_Homo sapiens_hsa052111.05416208
46GnRH signaling pathway_Homo sapiens_hsa049121.04808707
47Arachidonic acid metabolism_Homo sapiens_hsa005901.04694857
48Asthma_Homo sapiens_hsa053101.03142634
49Morphine addiction_Homo sapiens_hsa050321.03100760
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.02498496
51ErbB signaling pathway_Homo sapiens_hsa040121.01502083
52Protein digestion and absorption_Homo sapiens_hsa049741.01218266
53VEGF signaling pathway_Homo sapiens_hsa043701.00896302
54Focal adhesion_Homo sapiens_hsa045101.00549424
55Synaptic vesicle cycle_Homo sapiens_hsa047210.99709158
56Viral myocarditis_Homo sapiens_hsa054160.99284524
57Renin secretion_Homo sapiens_hsa049240.98223170
58Calcium signaling pathway_Homo sapiens_hsa040200.98215191
59Ras signaling pathway_Homo sapiens_hsa040140.97488396
60African trypanosomiasis_Homo sapiens_hsa051430.96874294
61Pertussis_Homo sapiens_hsa051330.96626739
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96076342
63Hippo signaling pathway_Homo sapiens_hsa043900.94515574
64Malaria_Homo sapiens_hsa051440.92912677
65Tuberculosis_Homo sapiens_hsa051520.92560621
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89817793
67Oxytocin signaling pathway_Homo sapiens_hsa049210.89269174
68Dorso-ventral axis formation_Homo sapiens_hsa043200.88925196
69Phenylalanine metabolism_Homo sapiens_hsa003600.88042309
70Insulin resistance_Homo sapiens_hsa049310.87266823
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85765346
72Allograft rejection_Homo sapiens_hsa053300.85736576
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85568666
74Primary immunodeficiency_Homo sapiens_hsa053400.85445711
75Vitamin digestion and absorption_Homo sapiens_hsa049770.82938001
76TNF signaling pathway_Homo sapiens_hsa046680.82821408
77PPAR signaling pathway_Homo sapiens_hsa033200.81278243
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80716577
79Measles_Homo sapiens_hsa051620.80656343
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.80609533
81Lysosome_Homo sapiens_hsa041420.79222284
82Osteoclast differentiation_Homo sapiens_hsa043800.78342649
83Platelet activation_Homo sapiens_hsa046110.77964423
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77739572
85Histidine metabolism_Homo sapiens_hsa003400.76984244
86Tryptophan metabolism_Homo sapiens_hsa003800.76433346
87Leishmaniasis_Homo sapiens_hsa051400.76416193
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.75531367
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.74978658
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74197971
91Salmonella infection_Homo sapiens_hsa051320.73330141
92Notch signaling pathway_Homo sapiens_hsa043300.72862603
93Rap1 signaling pathway_Homo sapiens_hsa040150.72776880
94Salivary secretion_Homo sapiens_hsa049700.72062829
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.71308176
96Tight junction_Homo sapiens_hsa045300.71108462
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70153055
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70013270
99Type II diabetes mellitus_Homo sapiens_hsa049300.68389012
100Toxoplasmosis_Homo sapiens_hsa051450.66417512
101Graft-versus-host disease_Homo sapiens_hsa053320.65633220
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63207858
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63058634
104Wnt signaling pathway_Homo sapiens_hsa043100.62094716
105MicroRNAs in cancer_Homo sapiens_hsa052060.61150106
106Bile secretion_Homo sapiens_hsa049760.60556916
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60229305
108Prolactin signaling pathway_Homo sapiens_hsa049170.59879289
109Influenza A_Homo sapiens_hsa051640.59344565
110Pancreatic secretion_Homo sapiens_hsa049720.59223281
111Fatty acid biosynthesis_Homo sapiens_hsa000610.58385000
112Lysine degradation_Homo sapiens_hsa003100.58009591
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.57427795
114cAMP signaling pathway_Homo sapiens_hsa040240.56506572
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56486207
116Hepatitis C_Homo sapiens_hsa051600.54213517
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54040708
118Fatty acid degradation_Homo sapiens_hsa000710.53492252
119Staphylococcus aureus infection_Homo sapiens_hsa051500.53199379
120Insulin signaling pathway_Homo sapiens_hsa049100.52671925
121Circadian entrainment_Homo sapiens_hsa047130.50423587
122Glutamatergic synapse_Homo sapiens_hsa047240.50390276
123Autoimmune thyroid disease_Homo sapiens_hsa053200.50260436
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50221514
125MAPK signaling pathway_Homo sapiens_hsa040100.49551481
126Prion diseases_Homo sapiens_hsa050200.49365987
127Pancreatic cancer_Homo sapiens_hsa052120.48762533
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.48687700
129Long-term depression_Homo sapiens_hsa047300.48346317
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48271495
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48197248
132Fat digestion and absorption_Homo sapiens_hsa049750.48005045
133GABAergic synapse_Homo sapiens_hsa047270.47954777
134Acute myeloid leukemia_Homo sapiens_hsa052210.47727485
135NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47588441
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.47207482
137Glycerolipid metabolism_Homo sapiens_hsa005610.46500526
138Choline metabolism in cancer_Homo sapiens_hsa052310.46133419
139Dilated cardiomyopathy_Homo sapiens_hsa054140.45594259
140Insulin secretion_Homo sapiens_hsa049110.45459938
141Pathways in cancer_Homo sapiens_hsa052000.45202920
142T cell receptor signaling pathway_Homo sapiens_hsa046600.45105211
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44256434
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41734102
145Estrogen signaling pathway_Homo sapiens_hsa049150.41719062

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