SLC27A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alanine transport (GO:0032328)5.20232159
2regulation of sequestering of triglyceride (GO:0010889)4.79984460
3biotin metabolic process (GO:0006768)4.12198012
4low-density lipoprotein particle clearance (GO:0034383)4.02081482
5L-serine transport (GO:0015825)4.01923032
6positive regulation of cellular amide metabolic process (GO:0034250)3.94860509
7regulation of synapse structural plasticity (GO:0051823)3.81401005
8serine transport (GO:0032329)3.73200500
9regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.61933502
10sodium ion export (GO:0071436)3.56465848
11cell communication by electrical coupling (GO:0010644)3.54875626
12carnitine shuttle (GO:0006853)3.54397405
13cilium or flagellum-dependent cell motility (GO:0001539)3.50292905
14behavioral response to nicotine (GO:0035095)3.50141882
15fatty acid transmembrane transport (GO:1902001)3.43941667
16cellular response to ATP (GO:0071318)3.40874526
17L-amino acid import (GO:0043092)3.38824993
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.38543110
19cellular potassium ion homeostasis (GO:0030007)3.31801288
20white fat cell differentiation (GO:0050872)3.31181776
21detection of light stimulus involved in visual perception (GO:0050908)3.26685233
22detection of light stimulus involved in sensory perception (GO:0050962)3.26685233
23regulation of cholesterol storage (GO:0010885)3.24729368
24amino acid import (GO:0043090)3.23371075
25brown fat cell differentiation (GO:0050873)3.22922307
26positive regulation of fatty acid oxidation (GO:0046321)3.19031537
27response to dietary excess (GO:0002021)3.15019598
28negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.09802279
29positive regulation of triglyceride biosynthetic process (GO:0010867)3.09076181
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.08712262
31positive regulation of fatty acid beta-oxidation (GO:0032000)3.07415218
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06584384
33proline transport (GO:0015824)3.05890275
34valine metabolic process (GO:0006573)3.05510363
35potassium ion import (GO:0010107)3.05115698
36carnitine transmembrane transport (GO:1902603)3.03558837
37glial cell proliferation (GO:0014009)3.02128906
38regulation of fatty acid oxidation (GO:0046320)2.97454968
39synaptic vesicle docking involved in exocytosis (GO:0016081)2.96362687
40regulation of triglyceride biosynthetic process (GO:0010866)2.96230199
41cellular response to cholesterol (GO:0071397)2.93807512
42regulation of cytokine production involved in inflammatory response (GO:1900015)2.93717550
43positive regulation of cholesterol efflux (GO:0010875)2.92472886
44neuronal action potential propagation (GO:0019227)2.92283643
45cellular sodium ion homeostasis (GO:0006883)2.87656107
46postsynaptic membrane organization (GO:0001941)2.85945827
47positive regulation of protein kinase C signaling (GO:0090037)2.85927508
48regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81970034
49phagocytosis, recognition (GO:0006910)2.78784507
50fatty acid beta-oxidation (GO:0006635)2.78181722
51urinary tract smooth muscle contraction (GO:0014848)2.77603758
52apoptotic cell clearance (GO:0043277)2.76106414
53fatty acid homeostasis (GO:0055089)2.75242904
54gamma-aminobutyric acid transport (GO:0015812)2.75144879
55negative regulation of cytosolic calcium ion concentration (GO:0051481)2.72506433
56positive regulation of glycogen biosynthetic process (GO:0045725)2.70494116
57triglyceride catabolic process (GO:0019433)2.70390314
58amino-acid betaine transport (GO:0015838)2.69977599
59carnitine transport (GO:0015879)2.69977599
60regulation of membrane repolarization (GO:0060306)2.67826772
61lipid particle organization (GO:0034389)2.66857521
62cGMP-mediated signaling (GO:0019934)2.66640988
63regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65508524
64glycine transport (GO:0015816)2.61441513
65adenosine receptor signaling pathway (GO:0001973)2.58840558
66negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.58190174
67triglyceride biosynthetic process (GO:0019432)2.58140895
68C4-dicarboxylate transport (GO:0015740)2.56937075
69dendritic spine morphogenesis (GO:0060997)2.56252581
70alpha-linolenic acid metabolic process (GO:0036109)2.55755351
71chondroitin sulfate catabolic process (GO:0030207)2.55537943
72axoneme assembly (GO:0035082)2.54472918
73central nervous system myelination (GO:0022010)2.52308440
74axon ensheathment in central nervous system (GO:0032291)2.52308440
75positive regulation of macrophage cytokine production (GO:0060907)2.51880264
76membrane depolarization during action potential (GO:0086010)2.50985428
77neuromuscular synaptic transmission (GO:0007274)2.50480211
78thioester biosynthetic process (GO:0035384)2.50150826
79acyl-CoA biosynthetic process (GO:0071616)2.50150826
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.49815596
81negative regulation of response to reactive oxygen species (GO:1901032)2.48700414
82acylglycerol biosynthetic process (GO:0046463)2.48604155
83neutral lipid biosynthetic process (GO:0046460)2.48604155
84response to gravity (GO:0009629)2.48584201
85negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.48300964
86regulation of skeletal muscle contraction (GO:0014819)2.47858759
87neutral lipid catabolic process (GO:0046461)2.47462543
88acylglycerol catabolic process (GO:0046464)2.47462543
89positive regulation of sterol transport (GO:0032373)2.47452325
90positive regulation of cholesterol transport (GO:0032376)2.47452325
91ovulation cycle (GO:0042698)2.46967232
92positive regulation of histone deacetylation (GO:0031065)2.46468413
93glycogen catabolic process (GO:0005980)2.45774627
94regulation of fatty acid beta-oxidation (GO:0031998)2.44681174
95positive regulation of triglyceride metabolic process (GO:0090208)2.44416239
96negative regulation of synaptic transmission, GABAergic (GO:0032229)2.43215362
97modulation by symbiont of host defense response (GO:0052031)2.43184052
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43184052
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43184052
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.43184052
101modulation by symbiont of host immune response (GO:0052553)2.43184052
102positive regulation by symbiont of host defense response (GO:0052509)2.43184052
103transepithelial transport (GO:0070633)2.42803006
104auditory receptor cell stereocilium organization (GO:0060088)2.42519774
105regulation of beta-amyloid formation (GO:1902003)2.41871821
106cellular response to sterol (GO:0036315)2.41675194
107negative regulation of stress fiber assembly (GO:0051497)2.41291013
108positive regulation of lipid storage (GO:0010884)2.40945142
109regulation of glycogen (starch) synthase activity (GO:2000465)2.40897846
110mannose metabolic process (GO:0006013)2.40522818
111L-fucose catabolic process (GO:0042355)2.39957803
112fucose catabolic process (GO:0019317)2.39957803
113L-fucose metabolic process (GO:0042354)2.39957803
114mitotic cell cycle arrest (GO:0071850)2.39470205
115response to auditory stimulus (GO:0010996)2.39056933
116potassium ion homeostasis (GO:0055075)2.38741430
117cell communication involved in cardiac conduction (GO:0086065)2.38139122
118regulation of memory T cell differentiation (GO:0043380)2.36624001
119negative regulation of lipid storage (GO:0010888)2.36485471
120regulation of action potential (GO:0098900)2.35486949
121lipid oxidation (GO:0034440)2.35149505
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.34658251
123positive regulation of cellular response to insulin stimulus (GO:1900078)2.34434355
124positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.34327189
125semaphorin-plexin signaling pathway (GO:0071526)2.34198561
126dermatan sulfate metabolic process (GO:0030205)2.34126950
127cardiac muscle contraction (GO:0060048)2.34104182
128lipid storage (GO:0019915)2.33069787
129synaptic transmission, cholinergic (GO:0007271)2.33006586
130positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.32366623
131branched-chain amino acid catabolic process (GO:0009083)2.31981247
132auditory behavior (GO:0031223)2.30984716
133positive regulation of p38MAPK cascade (GO:1900745)2.30859004
134positive regulation of CREB transcription factor activity (GO:0032793)2.30310381
135negative regulation of mast cell activation (GO:0033004)2.29625750
136response to lipoprotein particle (GO:0055094)2.29483415
137cilium movement (GO:0003341)2.29037158
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.28940277
139positive regulation of glycogen metabolic process (GO:0070875)2.28734980
140dermatan sulfate biosynthetic process (GO:0030208)2.28729278
141axonemal dynein complex assembly (GO:0070286)2.27338691
142regulation of synapse maturation (GO:0090128)2.26395810
143macroautophagy (GO:0016236)2.25798509
144synaptic transmission, glutamatergic (GO:0035249)2.24868598
145startle response (GO:0001964)2.24678768
146purinergic nucleotide receptor signaling pathway (GO:0035590)2.23011178
147cAMP catabolic process (GO:0006198)2.20434681
148neuromuscular process controlling posture (GO:0050884)2.19773691
149regulation of protein kinase A signaling (GO:0010738)2.19598818
150detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19263629
151neuronal action potential (GO:0019228)2.18796736
152motile cilium assembly (GO:0044458)2.18712844
153negative regulation of multicellular organism growth (GO:0040015)2.17514307
154cyclic nucleotide catabolic process (GO:0009214)2.17088709
155indolalkylamine catabolic process (GO:0046218)2.16666317
156tryptophan catabolic process (GO:0006569)2.16666317
157indole-containing compound catabolic process (GO:0042436)2.16666317
158negative regulation of Rho protein signal transduction (GO:0035024)2.14315589
159synaptic vesicle maturation (GO:0016188)2.13617982
160regulation of short-term neuronal synaptic plasticity (GO:0048172)2.11245828
161epithelial cilium movement (GO:0003351)2.07923115
162negative regulation of reactive oxygen species metabolic process (GO:2000378)2.06669282
163purinergic receptor signaling pathway (GO:0035587)2.05144158
164glutamate receptor signaling pathway (GO:0007215)2.04980765
165regulation of MHC class I biosynthetic process (GO:0045343)2.03707332
166sialylation (GO:0097503)2.03191457
167regulation of voltage-gated calcium channel activity (GO:1901385)2.01289779
168cerebellar Purkinje cell differentiation (GO:0021702)2.01288023
169indolalkylamine metabolic process (GO:0006586)2.01076597
170regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.99484049
171ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043161.97929286
172membrane depolarization (GO:0051899)1.95809649
173positive regulation of defense response to virus by host (GO:0002230)1.95178075
174neurotransmitter-gated ion channel clustering (GO:0072578)1.94170480
175kynurenine metabolic process (GO:0070189)1.93243418
176positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)1.93123219
177vocalization behavior (GO:0071625)1.92861779
178adult walking behavior (GO:0007628)1.92406045
179G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.91322372
180neuronal ion channel clustering (GO:0045161)1.91093067
181transmission of nerve impulse (GO:0019226)1.90548721
182cAMP metabolic process (GO:0046058)1.90217774
183behavioral response to pain (GO:0048266)1.89955485
184positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.87466647
185positive regulation of synapse maturation (GO:0090129)1.86545453
186cellular response to exogenous dsRNA (GO:0071360)1.86542386
187inner ear receptor stereocilium organization (GO:0060122)1.86404527
188NAD biosynthetic process (GO:0009435)1.85896193
189protein localization to cilium (GO:0061512)1.85157489
190synaptic vesicle exocytosis (GO:0016079)1.84123558
191negative regulation of protein localization to cell surface (GO:2000009)1.83517704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.65731551
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37728528
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.25152357
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07798719
5DROSHA_22980978_ChIP-Seq_HELA_Human2.06424502
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02735451
7EZH2_22144423_ChIP-Seq_EOC_Human2.02172833
8TRIM28_21343339_ChIP-Seq_HEK293_Human1.99832733
9CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95025387
10RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85066914
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85066914
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84160691
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.83602965
14CLOCK_20551151_ChIP-Seq_293T_Human1.78678033
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73285562
16ESR2_21235772_ChIP-Seq_MCF-7_Human1.70927632
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70276068
18AR_21572438_ChIP-Seq_LNCaP_Human1.69064909
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64883489
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.63880276
21CTCF_27219007_Chip-Seq_Bcells_Human1.60893501
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57986771
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57585737
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56720425
25REST_21632747_ChIP-Seq_MESCs_Mouse1.55590777
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.55413641
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55242089
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54475284
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.49976559
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.49493626
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.49219364
32* P68_20966046_ChIP-Seq_HELA_Human1.48962719
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48819654
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47469634
35* TBX20_22080862_ChIP-Seq_HEART_Mouse1.45467026
36* TBX20_22328084_ChIP-Seq_HEART_Mouse1.45467026
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44528077
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43946771
39VDR_22108803_ChIP-Seq_LS180_Human1.42678087
40PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42117865
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40600567
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.40548766
43GBX2_23144817_ChIP-Seq_PC3_Human1.36105155
44PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.32171613
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.29420036
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28133556
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27017214
48SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26700198
49BCL6_27268052_Chip-Seq_Bcells_Human1.25689294
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25214959
51* E2F1_20622854_ChIP-Seq_HELA_Human1.23484783
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23426453
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23076821
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21942576
55* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21146657
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.19696374
57RXR_22108803_ChIP-Seq_LS180_Human1.19568736
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18733553
59VDR_24787735_ChIP-Seq_THP-1_Human1.18051904
60SMC4_20622854_ChIP-Seq_HELA_Human1.17574088
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16475026
62ERA_21632823_ChIP-Seq_H3396_Human1.16142322
63AHR_22903824_ChIP-Seq_MCF-7_Human1.15512302
64* BCOR_27268052_Chip-Seq_Bcells_Human1.14792021
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.14229616
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14156429
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14125817
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13165731
69* OCT4_20526341_ChIP-Seq_ESCs_Human1.12705770
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12622225
71ZNF274_21170338_ChIP-Seq_K562_Hela1.12274585
72KDM2B_26808549_Chip-Seq_K562_Human1.12095862
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11346666
74CTCF_20526341_ChIP-Seq_ESCs_Human1.11038317
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09757392
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09652150
77* OCT4_19829295_ChIP-Seq_ESCs_Human1.09526445
78* PHF8_20622854_ChIP-Seq_HELA_Human1.08204744
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.08136304
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07961275
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.07517924
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.06778521
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06077790
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.05906794
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.05686558
86LXR_22292898_ChIP-Seq_THP-1_Human1.05198029
87VDR_21846776_ChIP-Seq_THP-1_Human1.05088760
88TP53_23651856_ChIP-Seq_MEFs_Mouse1.02704665
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02678526
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02486750
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02252538
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00950677
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.00299710
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99504920
95KLF4_19829295_ChIP-Seq_ESCs_Human0.99348540
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98698783
97TAF2_19829295_ChIP-Seq_ESCs_Human0.98675925
98TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98609046
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.98488122
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96544192
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95447912
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95406722
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95342167
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95210985
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93711699
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.93325004
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92982465
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92852413
109IRF8_22096565_ChIP-ChIP_GC-B_Human0.92628561
110TP53_16413492_ChIP-PET_HCT116_Human0.92365334
111SPI1_23127762_ChIP-Seq_K562_Human0.92260320
112MYC_19829295_ChIP-Seq_ESCs_Human0.91902405
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91650050
114RARB_27405468_Chip-Seq_BRAIN_Mouse0.91512082
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90842515
116CJUN_26792858_Chip-Seq_BT549_Human0.90356651
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90175218
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89799836
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89700723
120* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89373714
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.88141426
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87961175
123RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.87941992
124ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87502669
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.87337559
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87185659
127BCAT_22108803_ChIP-Seq_LS180_Human0.86456904
128AR_25329375_ChIP-Seq_VCAP_Human0.86445248
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86296089
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85085338
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.84705954
132E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84462165
133SMC3_22415368_ChIP-Seq_MEFs_Mouse0.83499936
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83083981
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.83031089
136KDM2B_26808549_Chip-Seq_DND41_Human0.82952462
137SA1_27219007_Chip-Seq_Bcells_Human0.82791677
138NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82567308
139NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82567308
140NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82394111
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82200711
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.82091639
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.81874253
144TP63_22573176_ChIP-Seq_HFKS_Human0.81670501
145TP53_22127205_ChIP-Seq_IMR90_Human0.81364538
146FOXA2_19822575_ChIP-Seq_HepG2_Human0.81309847
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80425694
148SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80048909
149YY1_22570637_ChIP-Seq_MALME-3M_Human0.79905585
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79435387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.53194441
2MP0005171_absent_coat_pigmentation3.91980236
3MP0005666_abnormal_adipose_tissue3.52933784
4MP0001986_abnormal_taste_sensitivity3.42365365
5MP0000751_myopathy3.25293995
6* MP0004130_abnormal_muscle_cell3.24816189
7MP0003646_muscle_fatigue3.23744438
8MP0003690_abnormal_glial_cell3.00902645
9MP0002837_dystrophic_cardiac_calcinosis2.98804383
10MP0003136_yellow_coat_color2.96684559
11MP0002254_reproductive_system_inflammat2.83294084
12MP0005423_abnormal_somatic_nervous2.78545164
13MP0005174_abnormal_tail_pigmentation2.62978130
14MP0001968_abnormal_touch/_nociception2.54552354
15MP0005375_adipose_tissue_phenotype2.52829896
16MP0004185_abnormal_adipocyte_glucose2.45016976
17MP0004215_abnormal_myocardial_fiber2.40028880
18MP0004858_abnormal_nervous_system2.31579160
19MP0005058_abnormal_lysosome_morphology2.22540890
20MP0008438_abnormal_cutaneous_collagen2.22438319
21MP0000569_abnormal_digit_pigmentation2.11250669
22MP0002971_abnormal_brown_adipose1.97200453
23MP0008875_abnormal_xenobiotic_pharmacok1.94235918
24MP0000750_abnormal_muscle_regeneration1.90119845
25MP0005551_abnormal_eye_electrophysiolog1.85689424
26MP0009745_abnormal_behavioral_response1.84171158
27MP0004084_abnormal_cardiac_muscle1.82436050
28MP0002064_seizures1.77488741
29MP0002909_abnormal_adrenal_gland1.75150594
30MP0002736_abnormal_nociception_after1.74826938
31MP0004036_abnormal_muscle_relaxation1.73157208
32MP0000749_muscle_degeneration1.72352528
33MP0002972_abnormal_cardiac_muscle1.70851015
34MP0004043_abnormal_pH_regulation1.69424677
35MP0003635_abnormal_synaptic_transmissio1.67589001
36MP0003279_aneurysm1.66569065
37MP0009115_abnormal_fat_cell1.64147932
38MP0004087_abnormal_muscle_fiber1.60231591
39MP0009780_abnormal_chondrocyte_physiolo1.57653447
40MP0002653_abnormal_ependyma_morphology1.57231004
41MP0009840_abnormal_foam_cell1.56226485
42MP0005620_abnormal_muscle_contractility1.56226286
43MP0000003_abnormal_adipose_tissue1.55171528
44MP0002735_abnormal_chemical_nociception1.53625697
45MP0003329_amyloid_beta_deposits1.51969311
46MP0003172_abnormal_lysosome_physiology1.50814414
47MP0002063_abnormal_learning/memory/cond1.50043013
48MP0002572_abnormal_emotion/affect_behav1.47921499
49MP0002272_abnormal_nervous_system1.47321112
50MP0006138_congestive_heart_failure1.46730963
51MP0003950_abnormal_plasma_membrane1.45224197
52MP0000013_abnormal_adipose_tissue1.44690595
53MP0001958_emphysema1.42797201
54MP0003137_abnormal_impulse_conducting1.41363255
55MP0001970_abnormal_pain_threshold1.39951176
56MP0000604_amyloidosis1.39241652
57MP0001544_abnormal_cardiovascular_syste1.38395039
58MP0005385_cardiovascular_system_phenoty1.38395039
59MP0008775_abnormal_heart_ventricle1.36750302
60MP0005167_abnormal_blood-brain_barrier1.36126601
61MP0003075_altered_response_to1.36032698
62MP0000343_altered_response_to1.32983539
63MP0003705_abnormal_hypodermis_morpholog1.32409441
64MP0005330_cardiomyopathy1.32291425
65MP0002638_abnormal_pupillary_reflex1.31203998
66MP0010329_abnormal_lipoprotein_level1.31189080
67MP0003828_pulmonary_edema1.30907911
68MP0001984_abnormal_olfaction1.29589446
69MP0002090_abnormal_vision1.27744227
70MP0005334_abnormal_fat_pad1.27690714
71MP0004381_abnormal_hair_follicle1.27679254
72MP0001853_heart_inflammation1.26997986
73MP0003634_abnormal_glial_cell1.26592335
74MP0003879_abnormal_hair_cell1.26015659
75MP0002106_abnormal_muscle_physiology1.24684906
76MP0000015_abnormal_ear_pigmentation1.22134060
77MP0002933_joint_inflammation1.19746703
78MP0005275_abnormal_skin_tensile1.17553996
79MP0005253_abnormal_eye_physiology1.17074562
80MP0010630_abnormal_cardiac_muscle1.16138791
81MP0005535_abnormal_body_temperature1.14596159
82MP0003191_abnormal_cellular_cholesterol1.14532930
83MP0008569_lethality_at_weaning1.12912270
84MP0003045_fibrosis1.12609517
85MP0000759_abnormal_skeletal_muscle1.11148643
86MP0002332_abnormal_exercise_endurance1.09708398
87MP0004859_abnormal_synaptic_plasticity1.07750687
88MP0001502_abnormal_circadian_rhythm1.07040587
89MP0002733_abnormal_thermal_nociception1.05177134
90MP0005083_abnormal_biliary_tract1.05047100
91MP0003566_abnormal_cell_adhesion1.04852332
92MP0003633_abnormal_nervous_system1.04542879
93MP0001756_abnormal_urination1.03356655
94MP0001501_abnormal_sleep_pattern1.01936900
95* MP0002118_abnormal_lipid_homeostasis1.01792820
96MP0005369_muscle_phenotype1.00408032
97MP0003880_abnormal_central_pattern0.98765996
98MP0009384_cardiac_valve_regurgitation0.97680000
99MP0002067_abnormal_sensory_capabilities0.97652143
100MP0002970_abnormal_white_adipose0.97275333
101MP0004133_heterotaxia0.96676919
102MP0001486_abnormal_startle_reflex0.96510852
103MP0004484_altered_response_of0.94930729
104MP0002734_abnormal_mechanical_nocicepti0.93817870
105MP0005409_darkened_coat_color0.93100411
106MP0003011_delayed_dark_adaptation0.91588558
107MP0004270_analgesia0.90425899
108MP0004233_abnormal_muscle_weight0.90220982
109MP0003183_abnormal_peptide_metabolism0.89963616
110MP0000230_abnormal_systemic_arterial0.88974969
111MP0004924_abnormal_behavior0.88605570
112MP0005386_behavior/neurological_phenoty0.88605570
113MP0002269_muscular_atrophy0.88592361
114MP0000747_muscle_weakness0.88075835
115MP0006276_abnormal_autonomic_nervous0.87810293
116MP0003195_calcinosis0.87428184
117MP0002557_abnormal_social/conspecific_i0.86220231
118MP0003632_abnormal_nervous_system0.86173468
119MP0003300_gastrointestinal_ulcer0.85414682
120MP0003878_abnormal_ear_physiology0.84827043
121MP0005377_hearing/vestibular/ear_phenot0.84827043
122MP0010386_abnormal_urinary_bladder0.83825620
123MP0004510_myositis0.83265593
124MP0009046_muscle_twitch0.83251486
125MP0001485_abnormal_pinna_reflex0.83212829
126MP0004142_abnormal_muscle_tone0.82675603
127MP0002229_neurodegeneration0.81536110
128MP0001963_abnormal_hearing_physiology0.80164952
129MP0005595_abnormal_vascular_smooth0.79788989
130MP0005448_abnormal_energy_balance0.79598283
131MP0000026_abnormal_inner_ear0.79026751
132MP0004885_abnormal_endolymph0.78875073
133MP0001881_abnormal_mammary_gland0.77228599
134MP0000778_abnormal_nervous_system0.76531749
135MP0002998_abnormal_bone_remodeling0.76387379
136MP0009278_abnormal_bone_marrow0.75800055
137MP0005646_abnormal_pituitary_gland0.75799641
138MP0005165_increased_susceptibility_to0.73202847
139MP0004272_abnormal_basement_membrane0.73040442
140MP0005365_abnormal_bile_salt0.72124117
141MP0002127_abnormal_cardiovascular_syste0.72123242
142MP0002876_abnormal_thyroid_physiology0.72019053
143MP0004085_abnormal_heartbeat0.70361528
144MP0008961_abnormal_basal_metabolism0.70212557
145MP0003948_abnormal_gas_homeostasis0.69735592
146MP0003631_nervous_system_phenotype0.69543859
147MP0005645_abnormal_hypothalamus_physiol0.69030853
148MP0004145_abnormal_muscle_electrophysio0.67784616
149MP0001661_extended_life_span0.65647723
150* MP0002078_abnormal_glucose_homeostasis0.64318374

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the upper limbs (HP:0009823)4.40222416
2Aplasia of the phalanges of the hand (HP:0009802)4.40222416
3Aplasia involving bones of the extremities (HP:0009825)4.40222416
4Exercise-induced myalgia (HP:0003738)4.24316475
5Difficulty running (HP:0009046)4.18889073
6Congenital stationary night blindness (HP:0007642)4.12570034
7Genetic anticipation (HP:0003743)3.99346277
8Myoglobinuria (HP:0002913)3.96867130
9Attenuation of retinal blood vessels (HP:0007843)3.56472571
10Rib fusion (HP:0000902)3.50089815
11Increased cerebral lipofuscin (HP:0011813)3.49528233
12Hyperglycinuria (HP:0003108)3.41633588
13Increased connective tissue (HP:0009025)3.33764697
14Megalencephaly (HP:0001355)3.27612263
15Progressive cerebellar ataxia (HP:0002073)3.21942490
16Atrial fibrillation (HP:0005110)3.16897647
17Asymmetric septal hypertrophy (HP:0001670)3.15826933
18Neurofibrillary tangles (HP:0002185)3.14935252
19Acanthosis nigricans (HP:0000956)3.03881136
20Hypertriglyceridemia (HP:0002155)3.02728793
21Muscle fiber splitting (HP:0003555)3.01944495
22Sudden death (HP:0001699)3.01916842
23Decreased central vision (HP:0007663)2.96113204
24Annular pancreas (HP:0001734)2.92052345
25Abnormal drinking behavior (HP:0030082)2.90164164
26Polydipsia (HP:0001959)2.90164164
27Hyperventilation (HP:0002883)2.89822888
28Primary atrial arrhythmia (HP:0001692)2.88372104
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87035290
30Broad metatarsal (HP:0001783)2.85327119
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.83737260
32Absent/shortened dynein arms (HP:0200106)2.83737260
33Absent speech (HP:0001344)2.82143557
34Decreased circulating renin level (HP:0003351)2.80440436
35Exercise-induced muscle cramps (HP:0003710)2.80215283
36Ketoacidosis (HP:0001993)2.79519715
37Ventricular tachycardia (HP:0004756)2.76305531
38Abnormality of midbrain morphology (HP:0002418)2.74884992
39Molar tooth sign on MRI (HP:0002419)2.74884992
40Hemiplegia (HP:0002301)2.74590788
41Abnormality of binocular vision (HP:0011514)2.73906539
42Diplopia (HP:0000651)2.73906539
43Prolonged QT interval (HP:0001657)2.73231855
44Lipoatrophy (HP:0100578)2.72151899
45Hyporeflexia of lower limbs (HP:0002600)2.72024779
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.71435469
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.71067857
48Testicular atrophy (HP:0000029)2.69465974
49Oligomenorrhea (HP:0000876)2.67761495
50Supraventricular tachycardia (HP:0004755)2.65068617
51Pancreatic cysts (HP:0001737)2.64845341
52Supraventricular arrhythmia (HP:0005115)2.63652532
53Abnormal respiratory motile cilium morphology (HP:0005938)2.61343448
54Abnormal respiratory epithelium morphology (HP:0012253)2.61343448
55Tetraparesis (HP:0002273)2.60846730
56Protruding tongue (HP:0010808)2.59016480
57Focal seizures (HP:0007359)2.58796183
58Bundle branch block (HP:0011710)2.58735028
59Nephronophthisis (HP:0000090)2.57394659
60Abnormality of glycine metabolism (HP:0010895)2.56893847
61Abnormality of serine family amino acid metabolism (HP:0010894)2.56893847
62Bony spicule pigmentary retinopathy (HP:0007737)2.53610567
63Fetal akinesia sequence (HP:0001989)2.51686504
64Hydroxyprolinuria (HP:0003080)2.51503454
65Abnormality of proline metabolism (HP:0010907)2.51503454
66Heart block (HP:0012722)2.48768382
67Abnormality of the calf musculature (HP:0001430)2.47182239
68Calf muscle hypertrophy (HP:0008981)2.47159154
69Akinesia (HP:0002304)2.46108367
70Cystic liver disease (HP:0006706)2.44292048
71Atrioventricular block (HP:0001678)2.43632915
72Turricephaly (HP:0000262)2.42997197
73Right ventricular cardiomyopathy (HP:0011663)2.41393443
74Supranuclear gaze palsy (HP:0000605)2.40449068
75Ventricular arrhythmia (HP:0004308)2.39508780
76Hypoalphalipoproteinemia (HP:0003233)2.39037077
77Cerebral inclusion bodies (HP:0100314)2.37519076
78Hemiparesis (HP:0001269)2.37297076
79Pancreatic fibrosis (HP:0100732)2.36408338
80Tubular atrophy (HP:0000092)2.36399979
81Chronic hepatic failure (HP:0100626)2.36317267
82Abnormal atrioventricular conduction (HP:0005150)2.36018591
83Joint stiffness (HP:0001387)2.35079084
84Adactyly (HP:0009776)2.34995019
85Abnormal ciliary motility (HP:0012262)2.34789162
86Aplasia of the musculature (HP:0100854)2.33862496
87Mesangial abnormality (HP:0001966)2.33276877
88True hermaphroditism (HP:0010459)2.29862056
89Axonal loss (HP:0003447)2.29528976
90Syncope (HP:0001279)2.28100438
91Pulmonary artery stenosis (HP:0004415)2.26918925
92Large for gestational age (HP:0001520)2.25578315
93Gaze-evoked nystagmus (HP:0000640)2.23351423
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23259766
95Obstructive sleep apnea (HP:0002870)2.22879929
96Muscle hypertrophy of the lower extremities (HP:0008968)2.21860966
97Abnormality of the renal medulla (HP:0100957)2.20502318
98Increased variability in muscle fiber diameter (HP:0003557)2.19948088
99Amyloidosis (HP:0011034)2.19196092
100Febrile seizures (HP:0002373)2.17392899
101Rhabdomyolysis (HP:0003201)2.17364631
102Abnormality of the hepatic vasculature (HP:0006707)2.15086927
103Hypoplastic left heart (HP:0004383)2.14030898
104Humeroradial synostosis (HP:0003041)2.13762687
105Synostosis involving the elbow (HP:0003938)2.13762687
106Congenital sensorineural hearing impairment (HP:0008527)2.13275891
107Focal motor seizures (HP:0011153)2.12651042
108Myotonia (HP:0002486)2.12534431
109Cerebral aneurysm (HP:0004944)2.11450266
110Global brain atrophy (HP:0002283)2.11413211
111Macular degeneration (HP:0000608)2.09726125
112Insulin-resistant diabetes mellitus (HP:0000831)2.09411610
113Thin bony cortex (HP:0002753)2.08890359
114Polyuria (HP:0000103)2.08850176
115Congenital hepatic fibrosis (HP:0002612)2.08008635
116Dilated cardiomyopathy (HP:0001644)2.06144656
117Broad-based gait (HP:0002136)2.05413290
118Facial diplegia (HP:0001349)2.04590649
119Chorioretinal atrophy (HP:0000533)2.02015130
120Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01480620
121Abnormality of polysaccharide metabolism (HP:0011012)2.01480620
122Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01480620
123Choroideremia (HP:0001139)2.00178247
124Hemorrhage of the eye (HP:0011885)1.99760019
125Abnormality of liposaccharide metabolism (HP:0010968)1.99587384
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.99587384
127Abnormality of glycolipid metabolism (HP:0010969)1.99587384
128Abnormal EKG (HP:0003115)1.98174426
129Dysostosis multiplex (HP:0000943)1.97824609
130Clumsiness (HP:0002312)1.97574346
131Muscle stiffness (HP:0003552)1.95781472
132Postural instability (HP:0002172)1.95676221
133Abnormal respiratory motile cilium physiology (HP:0012261)1.95612539
134Urinary bladder sphincter dysfunction (HP:0002839)1.94692536
135Action tremor (HP:0002345)1.93903175
136Epileptic encephalopathy (HP:0200134)1.93551303
137Myocardial infarction (HP:0001658)1.89685038
138Mucopolysacchariduria (HP:0008155)1.89547978
139Urinary glycosaminoglycan excretion (HP:0003541)1.89547978
140Ketosis (HP:0001946)1.88683341
141Intellectual disability, severe (HP:0010864)1.87316778
142Bradycardia (HP:0001662)1.86899062
143Subcapsular cataract (HP:0000523)1.86068969
144Prenatal maternal abnormality (HP:0002686)1.85627328
145Loss of speech (HP:0002371)1.85115781
146Type 1 muscle fiber predominance (HP:0003803)1.84815749
147Impaired smooth pursuit (HP:0007772)1.84758458
148Abnormality of fatty-acid metabolism (HP:0004359)1.84644550
149Bone cyst (HP:0012062)1.83767878
150Type II lissencephaly (HP:0007260)1.83573218
151Abnormality of skeletal muscle fiber size (HP:0012084)1.82737472
152Subaortic stenosis (HP:0001682)1.82088543
153Abnormality of the left ventricular outflow tract (HP:0011103)1.82088543
154Abolished electroretinogram (ERG) (HP:0000550)1.82010590
155Abnormal eating behavior (HP:0100738)1.81847379
156Gowers sign (HP:0003391)1.80324637
157Frequent falls (HP:0002359)1.79488551
158Neonatal respiratory distress (HP:0002643)1.79028748
159Maternal diabetes (HP:0009800)1.78415975
160Left ventricular hypertrophy (HP:0001712)1.76191647
161Medial flaring of the eyebrow (HP:0010747)1.76110921
162Abnormal urine output (HP:0012590)1.75043926
163Proximal amyotrophy (HP:0007126)1.74863035
164Enlarged epiphyses (HP:0010580)1.72768191
165Hypoalbuminemia (HP:0003073)1.69454834
166Abnormal albumin level (HP:0012116)1.69454834
167Hypoplasia of the odontoid process (HP:0003311)1.68841852
168Bronchomalacia (HP:0002780)1.68727480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.76082851
2TRIB34.47648789
3MAPK154.28564696
4FRK4.19958270
5CAMK1D3.64198624
6PHKG13.62556570
7PHKG23.62556570
8CAMK1G3.17896660
9SIK13.08650946
10TTN2.76245364
11PRKD32.44780044
12WNK42.17022702
13BCKDK2.08847233
14IRAK32.04843582
15ADRBK22.04023097
16ACVR1B2.02847290
17MARK11.95150518
18TLK11.92192076
19RIPK11.79408575
20PDK41.75931663
21PDK31.75931663
22BMPR1B1.74876413
23NTRK21.66617351
24EPHA41.60337326
25MUSK1.59731295
26TNIK1.58749867
27BLK1.56044967
28TNK21.52777773
29MAP2K61.49365764
30PINK11.42810663
31INSRR1.42145427
32PRKAA21.36765496
33CDK191.35456904
34OXSR11.33713090
35ERN11.30696300
36GRK11.28936678
37ADRBK11.26285249
38PKN21.23982518
39DMPK1.23692072
40OBSCN1.20649985
41SGK31.15145318
42MAPKAPK31.14281077
43MAPK121.09891184
44SGK21.09415651
45TAOK31.04934769
46EPHB11.02172253
47STK111.01495665
48MAP4K20.97667645
49PDGFRA0.95894787
50PDK20.93656283
51SGK4940.91836954
52SGK2230.91836954
53FGFR30.90820537
54STK380.89528395
55DAPK20.88461246
56PRKCH0.87620960
57JAK10.87574005
58PRKAA10.81382034
59KIT0.80832795
60RPS6KA20.80630067
61DDR20.79853824
62CAMK10.79759004
63TAOK20.79119986
64PTK60.77044811
65TIE10.75892690
66PRKD10.75873590
67MAP3K70.74841475
68HIPK20.74560820
69PAK60.74156726
70TXK0.73398121
71PIK3CA0.72519306
72TGFBR10.72231942
73FGR0.70680591
74RIPK40.68516368
75PRKCG0.67555955
76RPS6KA60.67268602
77BMX0.66044974
78MAP3K110.65977139
79ERBB20.65828442
80PRKD20.65010453
81PTK2B0.63514006
82MYLK0.63164199
83PRPF4B0.60981469
84ROCK10.60301557
85GRK50.60252031
86CSK0.58714267
87SIK20.58597477
88MAP3K130.57956784
89SGK10.57604886
90FGFR20.57423050
91PDPK10.57246178
92CDC42BPA0.56125341
93JAK30.56038378
94TYRO30.55564847
95MAP3K60.53872600
96CAMKK20.53440294
97TGFBR20.52616126
98CAMK40.52482921
99CAMKK10.52441541
100EPHB20.51520031
101PDGFRB0.51299336
102WNK10.50771307
103PRKACG0.50197576
104MARK20.49555933
105JAK20.48754939
106TRPM70.48547843
107CAMK2A0.48274060
108ZAP700.47937446
109PRKCE0.47376336
110AKT30.46968334
111CASK0.46691426
112PKN10.46028831
113TBK10.45986839
114RPS6KL10.45301063
115RPS6KC10.45301063
116ICK0.45023934
117PAK30.44569911
118RET0.44393187
119CDK50.44008962
120MAP2K40.43763490
121PRKACA0.43166537
122FES0.43150005
123GRK70.42925429
124MAPK70.41851742
125SRC0.41552634
126IGF1R0.40970727
127ILK0.40015393
128PRKG10.39684311
129CAMK2B0.38859615
130NTRK10.37908832
131FER0.37840907
132HCK0.37680507
133EPHA30.37442853
134PDK10.37285897
135FGFR40.36961276
136NTRK30.34588182
137RPS6KA30.32362873
138MAPK130.30765029
139MTOR0.30383647
140CAMK2D0.29739468
141MAP2K10.28605844
142MAP2K30.28573826
143CDK90.28278817
144AKT20.27875696

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.76499497
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.58870376
3Fatty acid metabolism_Homo sapiens_hsa012123.20418123
4Propanoate metabolism_Homo sapiens_hsa006402.97261316
5Fatty acid degradation_Homo sapiens_hsa000712.71630485
6Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.62364329
7Nitrogen metabolism_Homo sapiens_hsa009102.48189416
8* PPAR signaling pathway_Homo sapiens_hsa033202.43615239
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34775537
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08388219
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99974486
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89497827
13Adipocytokine signaling pathway_Homo sapiens_hsa049201.88644924
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72822416
15Glycerolipid metabolism_Homo sapiens_hsa005611.70034591
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63692621
17Dilated cardiomyopathy_Homo sapiens_hsa054141.47366483
18Histidine metabolism_Homo sapiens_hsa003401.46406719
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42635775
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.39808008
21Phototransduction_Homo sapiens_hsa047441.37622934
22Taste transduction_Homo sapiens_hsa047421.34352570
23Ovarian steroidogenesis_Homo sapiens_hsa049131.29736569
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28587466
25Lysosome_Homo sapiens_hsa041421.28382299
26Linoleic acid metabolism_Homo sapiens_hsa005911.21474086
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18873431
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15347589
29Sulfur relay system_Homo sapiens_hsa041221.13368108
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13051690
31Carbon metabolism_Homo sapiens_hsa012001.10002895
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08439602
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08355337
34AMPK signaling pathway_Homo sapiens_hsa041521.06436805
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.05943778
36Renin secretion_Homo sapiens_hsa049241.05822746
37Salivary secretion_Homo sapiens_hsa049701.04157450
38Cocaine addiction_Homo sapiens_hsa050301.03720347
39Fatty acid elongation_Homo sapiens_hsa000621.02916113
40* Insulin resistance_Homo sapiens_hsa049311.02462832
41Type II diabetes mellitus_Homo sapiens_hsa049301.02252783
42Insulin signaling pathway_Homo sapiens_hsa049101.01470863
43beta-Alanine metabolism_Homo sapiens_hsa004101.01267752
44Caffeine metabolism_Homo sapiens_hsa002320.99537782
45Ether lipid metabolism_Homo sapiens_hsa005650.97856228
46Gastric acid secretion_Homo sapiens_hsa049710.97718858
47Tryptophan metabolism_Homo sapiens_hsa003800.96378932
48Synaptic vesicle cycle_Homo sapiens_hsa047210.94286770
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94091504
50Pyruvate metabolism_Homo sapiens_hsa006200.93377805
51cAMP signaling pathway_Homo sapiens_hsa040240.88431734
52Cardiac muscle contraction_Homo sapiens_hsa042600.87266262
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87062460
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86524105
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86050872
56Amphetamine addiction_Homo sapiens_hsa050310.85910811
57Glucagon signaling pathway_Homo sapiens_hsa049220.84525633
58Calcium signaling pathway_Homo sapiens_hsa040200.83597482
59Insulin secretion_Homo sapiens_hsa049110.78730543
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.78032495
61Serotonergic synapse_Homo sapiens_hsa047260.77136041
62Peroxisome_Homo sapiens_hsa041460.76094096
63Dopaminergic synapse_Homo sapiens_hsa047280.74984591
64Lysine degradation_Homo sapiens_hsa003100.74875210
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71830983
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.71325393
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71284556
68Axon guidance_Homo sapiens_hsa043600.69335410
69Fructose and mannose metabolism_Homo sapiens_hsa000510.69308298
70Circadian entrainment_Homo sapiens_hsa047130.68616610
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68361776
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67504286
73Dorso-ventral axis formation_Homo sapiens_hsa043200.66963531
74Butanoate metabolism_Homo sapiens_hsa006500.65873254
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65689617
76Morphine addiction_Homo sapiens_hsa050320.65232248
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64975004
78Staphylococcus aureus infection_Homo sapiens_hsa051500.64450715
79Circadian rhythm_Homo sapiens_hsa047100.64387281
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63849987
81Collecting duct acid secretion_Homo sapiens_hsa049660.63737894
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63104830
83Other glycan degradation_Homo sapiens_hsa005110.62724371
84Pancreatic secretion_Homo sapiens_hsa049720.62106403
85MAPK signaling pathway_Homo sapiens_hsa040100.60501256
86Glutamatergic synapse_Homo sapiens_hsa047240.60473483
87GABAergic synapse_Homo sapiens_hsa047270.60245379
88Chemical carcinogenesis_Homo sapiens_hsa052040.59481173
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.59189768
90ECM-receptor interaction_Homo sapiens_hsa045120.59167359
91Long-term depression_Homo sapiens_hsa047300.58930991
92Olfactory transduction_Homo sapiens_hsa047400.58660242
93Malaria_Homo sapiens_hsa051440.54094480
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.53434184
95Notch signaling pathway_Homo sapiens_hsa043300.53277144
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.52931898
97Starch and sucrose metabolism_Homo sapiens_hsa005000.51836119
98mTOR signaling pathway_Homo sapiens_hsa041500.51387394
99Focal adhesion_Homo sapiens_hsa045100.51316080
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50942142
101Arachidonic acid metabolism_Homo sapiens_hsa005900.49655378
102Viral myocarditis_Homo sapiens_hsa054160.49280554
103Protein digestion and absorption_Homo sapiens_hsa049740.49051554
104Basal cell carcinoma_Homo sapiens_hsa052170.48740492
105Osteoclast differentiation_Homo sapiens_hsa043800.48609595
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48103860
107Oxytocin signaling pathway_Homo sapiens_hsa049210.47965031
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47751536
109Ras signaling pathway_Homo sapiens_hsa040140.46877887
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.46035137
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45937800
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44957614
113Proteoglycans in cancer_Homo sapiens_hsa052050.44716504
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44704936
115HIF-1 signaling pathway_Homo sapiens_hsa040660.43827429
116Estrogen signaling pathway_Homo sapiens_hsa049150.42349143
117Melanogenesis_Homo sapiens_hsa049160.42269158
118Mineral absorption_Homo sapiens_hsa049780.42240306
119Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42011039
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41578938
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41411219
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.41338250
123Bile secretion_Homo sapiens_hsa049760.40759831
124ABC transporters_Homo sapiens_hsa020100.40091986
125Cholinergic synapse_Homo sapiens_hsa047250.39491784
126Sphingolipid metabolism_Homo sapiens_hsa006000.38654864
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38355723
128Platelet activation_Homo sapiens_hsa046110.38073570
129Rheumatoid arthritis_Homo sapiens_hsa053230.37303934
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.37297188
131Nicotine addiction_Homo sapiens_hsa050330.37284246
132Long-term potentiation_Homo sapiens_hsa047200.36992910
133Tuberculosis_Homo sapiens_hsa051520.36845555
134Rap1 signaling pathway_Homo sapiens_hsa040150.35950220
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35512504
136GnRH signaling pathway_Homo sapiens_hsa049120.34319452
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.34091947
138Amoebiasis_Homo sapiens_hsa051460.33019220
139Toxoplasmosis_Homo sapiens_hsa051450.32604086
140Inositol phosphate metabolism_Homo sapiens_hsa005620.30999573
141Galactose metabolism_Homo sapiens_hsa000520.30445276
142Pentose phosphate pathway_Homo sapiens_hsa000300.30309971

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