SLC27A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.97953893
2L-phenylalanine catabolic process (GO:0006559)7.42286475
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.42286475
4L-phenylalanine metabolic process (GO:0006558)7.18168182
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.18168182
6omega-hydroxylase P450 pathway (GO:0097267)7.09292792
7aromatic amino acid family catabolic process (GO:0009074)6.91538338
8glyoxylate metabolic process (GO:0046487)6.51248268
9indole-containing compound catabolic process (GO:0042436)6.43043615
10indolalkylamine catabolic process (GO:0046218)6.43043615
11tryptophan catabolic process (GO:0006569)6.43043615
12cysteine metabolic process (GO:0006534)6.21622848
13lysine metabolic process (GO:0006553)6.21275992
14lysine catabolic process (GO:0006554)6.21275992
15ethanol metabolic process (GO:0006067)6.09457181
16kynurenine metabolic process (GO:0070189)6.08860612
17tryptophan metabolic process (GO:0006568)6.05875858
18urate metabolic process (GO:0046415)5.54319886
19drug transmembrane transport (GO:0006855)5.50233001
20primary alcohol catabolic process (GO:0034310)5.49062171
21serine family amino acid catabolic process (GO:0009071)5.43318783
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.38790747
23fibrinolysis (GO:0042730)5.31055892
24homocysteine metabolic process (GO:0050667)5.27734593
25sulfur amino acid catabolic process (GO:0000098)5.26495964
26* bile acid biosynthetic process (GO:0006699)5.24196688
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.19490046
28alpha-linolenic acid metabolic process (GO:0036109)5.17995452
29amino-acid betaine metabolic process (GO:0006577)5.07146976
30axonemal dynein complex assembly (GO:0070286)5.06066510
31aromatic amino acid family metabolic process (GO:0009072)5.04924858
32blood coagulation, intrinsic pathway (GO:0007597)5.03909779
33urea cycle (GO:0000050)4.99428173
34urea metabolic process (GO:0019627)4.99428173
35oxidative demethylation (GO:0070989)4.89415664
36drug catabolic process (GO:0042737)4.84686645
37cellular ketone body metabolic process (GO:0046950)4.84125571
38alpha-amino acid catabolic process (GO:1901606)4.77483063
39serine family amino acid metabolic process (GO:0009069)4.65363895
40nitrogen cycle metabolic process (GO:0071941)4.64057349
41drug transport (GO:0015893)4.62502664
42glutamate metabolic process (GO:0006536)4.59922361
43indolalkylamine metabolic process (GO:0006586)4.55336061
44negative regulation of fibrinolysis (GO:0051918)4.55165384
45cellular modified amino acid catabolic process (GO:0042219)4.55135132
46regulation of humoral immune response (GO:0002920)4.53736219
47short-chain fatty acid metabolic process (GO:0046459)4.51782490
48phenylpropanoid metabolic process (GO:0009698)4.51474813
49tyrosine metabolic process (GO:0006570)4.51275299
50cellular amino acid catabolic process (GO:0009063)4.50285433
51protein carboxylation (GO:0018214)4.49866945
52peptidyl-glutamic acid carboxylation (GO:0017187)4.49866945
53high-density lipoprotein particle remodeling (GO:0034375)4.49238541
54protein activation cascade (GO:0072376)4.48165910
55* bile acid metabolic process (GO:0008206)4.47608423
56aspartate family amino acid catabolic process (GO:0009068)4.41746999
57complement activation, classical pathway (GO:0006958)4.38661016
58cellular biogenic amine catabolic process (GO:0042402)4.38193802
59amine catabolic process (GO:0009310)4.38193802
60regulation of fibrinolysis (GO:0051917)4.35171688
61complement activation, alternative pathway (GO:0006957)4.35006372
62exogenous drug catabolic process (GO:0042738)4.34803227
63benzene-containing compound metabolic process (GO:0042537)4.33256833
64regulation of protein activation cascade (GO:2000257)4.30334751
65complement activation (GO:0006956)4.28100165
66serine family amino acid biosynthetic process (GO:0009070)4.27115936
67cellular glucuronidation (GO:0052695)4.22555419
68negative regulation of protein activation cascade (GO:2000258)4.21536459
69acetyl-CoA metabolic process (GO:0006084)4.20254663
70glycine metabolic process (GO:0006544)4.19732335
71ketone body metabolic process (GO:1902224)4.18744735
72negative regulation of cholesterol transport (GO:0032375)4.16134126
73negative regulation of sterol transport (GO:0032372)4.16134126
742-oxoglutarate metabolic process (GO:0006103)4.15939173
75cilium or flagellum-dependent cell motility (GO:0001539)4.13263347
76acute-phase response (GO:0006953)4.11028457
77negative regulation of hemostasis (GO:1900047)4.08154396
78negative regulation of blood coagulation (GO:0030195)4.08154396
79daunorubicin metabolic process (GO:0044597)4.07860620
80polyketide metabolic process (GO:0030638)4.07860620
81doxorubicin metabolic process (GO:0044598)4.07860620
82coenzyme catabolic process (GO:0009109)4.07489978
83regulation of triglyceride catabolic process (GO:0010896)4.06698781
84aldehyde catabolic process (GO:0046185)4.05007656
85regulation of complement activation (GO:0030449)4.01872202
86acylglycerol homeostasis (GO:0055090)4.01321581
87triglyceride homeostasis (GO:0070328)4.01321581
88regulation of plasminogen activation (GO:0010755)4.00369857
89dicarboxylic acid biosynthetic process (GO:0043650)4.00316422
90ethanol oxidation (GO:0006069)4.00007791
91* organic acid catabolic process (GO:0016054)3.97003834
92* carboxylic acid catabolic process (GO:0046395)3.97003834
93response to mercury ion (GO:0046689)3.96997085
94carnitine metabolic process (GO:0009437)3.96560276
95hormone catabolic process (GO:0042447)3.95532688
96regulation of cholesterol esterification (GO:0010872)3.94802414
97very-low-density lipoprotein particle assembly (GO:0034379)3.94016506
98reverse cholesterol transport (GO:0043691)3.92932969
99glucuronate metabolic process (GO:0019585)3.91886628
100uronic acid metabolic process (GO:0006063)3.91886628
101protein-lipid complex remodeling (GO:0034368)3.88304454
102macromolecular complex remodeling (GO:0034367)3.88304454
103plasma lipoprotein particle remodeling (GO:0034369)3.88304454
104bile acid and bile salt transport (GO:0015721)3.85102314
105positive regulation of triglyceride lipase activity (GO:0061365)3.84079024
106positive regulation of lipoprotein lipase activity (GO:0051006)3.84079024
107valine metabolic process (GO:0006573)3.82969288
108* fatty acid beta-oxidation (GO:0006635)3.81107543
109* fatty acid oxidation (GO:0019395)3.80423160
110heme transport (GO:0015886)3.74544762
111* lipid oxidation (GO:0034440)3.72926741
112regulation of cholesterol homeostasis (GO:2000188)3.71487082
113aminoglycoside antibiotic metabolic process (GO:0030647)3.70277426
114cytolysis (GO:0019835)3.69659410
115negative regulation of coagulation (GO:0050819)3.69475649
116arginine metabolic process (GO:0006525)3.68688955
117* monocarboxylic acid catabolic process (GO:0072329)3.68182819
118negative regulation of humoral immune response (GO:0002921)3.67434126
119cholesterol efflux (GO:0033344)3.65297101
120phospholipid efflux (GO:0033700)3.64899789
121imidazole-containing compound metabolic process (GO:0052803)3.64043772
122drug metabolic process (GO:0017144)3.63286734
123proline metabolic process (GO:0006560)3.61052410
124negative regulation of wound healing (GO:0061045)3.60772642
125plasma lipoprotein particle clearance (GO:0034381)3.60453877
126intestinal cholesterol absorption (GO:0030299)3.58869642
127positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.58778093
128primary alcohol metabolic process (GO:0034308)3.58536452
129branched-chain amino acid metabolic process (GO:0009081)3.57456062
130flavonoid metabolic process (GO:0009812)3.57337880
131xenobiotic metabolic process (GO:0006805)3.56834354
132regulation of bile acid biosynthetic process (GO:0070857)3.56449335
133* fatty acid catabolic process (GO:0009062)3.56350314
134regulation of apoptotic cell clearance (GO:2000425)3.54500880
135organic cation transport (GO:0015695)3.53415159
136phosphate ion transport (GO:0006817)3.52060220
137S-adenosylmethionine metabolic process (GO:0046500)3.51925125
138opsonization (GO:0008228)3.51870685
139branched-chain amino acid catabolic process (GO:0009083)3.48468597
140diterpenoid biosynthetic process (GO:0016102)3.44624629
141motile cilium assembly (GO:0044458)3.44180789
142fat-soluble vitamin biosynthetic process (GO:0042362)3.43932541
143response to nitrosative stress (GO:0051409)3.43507997
144indole-containing compound metabolic process (GO:0042430)3.43038674
145negative regulation of lipase activity (GO:0060192)3.39214404
146negative regulation of complement activation (GO:0045916)3.38594158
147disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.35847076
148killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.35847076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.20809258
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.01868639
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.33957470
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.32471758
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01660527
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92455428
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.51555117
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.87355549
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.73602625
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79605570
11E2F7_22180533_ChIP-Seq_HELA_Human2.57628405
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33212742
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29768419
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.15975199
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4346418
16CLOCK_20551151_ChIP-Seq_293T_Human1.73792307
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.66367653
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.53160933
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46121012
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34709186
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24042828
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22753537
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18431201
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16493231
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15758144
26GATA1_22025678_ChIP-Seq_K562_Human1.15649501
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15035463
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.14830141
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13383329
30HTT_18923047_ChIP-ChIP_STHdh_Human1.12905653
31SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10820779
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10626561
33RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10334201
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09354354
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.07683569
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06483716
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05757619
38SMC4_20622854_ChIP-Seq_HELA_Human1.04956859
39GATA3_24758297_ChIP-Seq_MCF-7_Human1.04691440
40GATA4_25053715_ChIP-Seq_YYC3_Human1.04029179
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03898773
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.02676496
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00045953
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98565342
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91689692
46ELF1_20517297_ChIP-Seq_JURKAT_Human0.91082133
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88490883
48RUNX1_27514584_Chip-Seq_MCF-7_Human0.88062030
49GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87935310
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.86449292
51* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86089570
52HNFA_21074721_ChIP-Seq_CACO-2_Human0.85568482
53MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83141907
54CDX2_20551321_ChIP-Seq_CACO-2_Human0.83050220
55GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82384089
56AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80725647
57P68_20966046_ChIP-Seq_HELA_Human0.80618625
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80558667
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80358537
60ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79947415
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79125603
62PHF8_20622854_ChIP-Seq_HELA_Human0.78348831
63PHF8_20622853_ChIP-Seq_HELA_Human0.78032879
64NCOR1_26117541_ChIP-Seq_K562_Human0.76968579
65ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76968515
66KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74196507
67IRF8_22096565_ChIP-ChIP_GC-B_Human0.73527650
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73375001
69GATA6_21074721_ChIP-Seq_CACO-2_Human0.72898937
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72615280
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72287081
72LXR_22292898_ChIP-Seq_THP-1_Human0.72116367
73EGR1_19032775_ChIP-ChIP_M12_Human0.71969177
74BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71812927
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.71410663
76E2F1_20622854_ChIP-Seq_HELA_Human0.71367872
77CHD1_26751641_Chip-Seq_LNCaP_Human0.70614571
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68944835
79CREB1_26743006_Chip-Seq_LNCaP_Human0.68892391
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68379072
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.68118730
82P300_27268052_Chip-Seq_Bcells_Human0.67933533
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.67782075
84ZNF263_19887448_ChIP-Seq_K562_Human0.67049543
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.67047701
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.66719973
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66316264
88NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66316264
89DCP1A_22483619_ChIP-Seq_HELA_Human0.65404075
90BCOR_27268052_Chip-Seq_Bcells_Human0.64657933
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64540404
92RARA_24833708_ChIP-Seq_LIVER_Mouse0.64236772
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64130053
94* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62949005
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.62467622
96FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62159474
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.61870929
98CEBPB_22108803_ChIP-Seq_LS180_Human0.61714394
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.61403742
100GATA6_25053715_ChIP-Seq_YYC3_Human0.61346639
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.61044664
102MYC_19030024_ChIP-ChIP_MESCs_Mouse0.60637617
103* MYC_19915707_ChIP-ChIP_AK7_Human0.58970710
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.58407452
105AR_20517297_ChIP-Seq_VCAP_Human0.57510492
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.56636235
107ESET_19884257_ChIP-Seq_ESCs_Mouse0.54780279
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54545748
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.53901062
110STAT1_17558387_ChIP-Seq_HELA_Human0.53313461
111RARB_24833708_ChIP-Seq_LIVER_Mouse0.52293938
112CBP_21632823_ChIP-Seq_H3396_Human0.51727770
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50771711
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.50718050
115TAF2_19829295_ChIP-Seq_ESCs_Human0.50559781
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50556533
117AR_21909140_ChIP-Seq_LNCAP_Human0.50173144
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.48985494
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48401833
120RACK7_27058665_Chip-Seq_MCF-7_Human0.47267919
121GATA2_19941826_ChIP-Seq_K562_Human0.47163918
122CDX2_22108803_ChIP-Seq_LS180_Human0.47122281
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.47087614
124SOX2_20726797_ChIP-Seq_SW620_Human0.46780384
125PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46202279
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45896239
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44875227
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44427529
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44385403
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44342122
131P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.43916522
132GATA1_19941826_ChIP-Seq_K562_Human0.43406115
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.43240952
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.42584924
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.41915227
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40981160
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40760307
138TRIM28_21343339_ChIP-Seq_HEK293_Human0.40652982
139P53_21459846_ChIP-Seq_SAOS-2_Human0.40582257
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40562478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.24934935
2MP0002139_abnormal_hepatobiliary_system7.96426307
3MP0005085_abnormal_gallbladder_physiolo5.77642574
4MP0005365_abnormal_bile_salt5.65508950
5MP0008875_abnormal_xenobiotic_pharmacok4.97894390
6MP0003252_abnormal_bile_duct3.85758173
7MP0003806_abnormal_nucleotide_metabolis3.77873230
8MP0005332_abnormal_amino_acid3.62617697
9MP0003195_calcinosis3.49453119
10MP0004019_abnormal_vitamin_homeostasis3.13604368
11MP0010329_abnormal_lipoprotein_level3.07290974
12MP0002138_abnormal_hepatobiliary_system2.69640528
13MP0009840_abnormal_foam_cell2.54678228
14MP0005083_abnormal_biliary_tract2.47905985
15MP0001666_abnormal_nutrient_absorption2.40394984
16MP0002132_abnormal_respiratory_system2.29078556
17MP0003191_abnormal_cellular_cholesterol2.14854999
18MP0009643_abnormal_urine_homeostasis2.11463567
19MP0004043_abnormal_pH_regulation1.96116465
20MP0002118_abnormal_lipid_homeostasis1.93335079
21MP0000609_abnormal_liver_physiology1.90420443
22MP0005319_abnormal_enzyme/_coenzyme1.83540128
23MP0005584_abnormal_enzyme/coenzyme_acti1.70109833
24MP0001764_abnormal_homeostasis1.63829869
25MP0005636_abnormal_mineral_homeostasis1.62242173
26MP0005451_abnormal_body_composition1.60543453
27MP0003868_abnormal_feces_composition1.52058102
28MP0003186_abnormal_redox_activity1.51592317
29MP0001756_abnormal_urination1.41828710
30MP0002136_abnormal_kidney_physiology1.21081957
31MP0001765_abnormal_ion_homeostasis1.18979528
32MP0000598_abnormal_liver_morphology1.07682007
33MP0002876_abnormal_thyroid_physiology1.02335696
34MP0006036_abnormal_mitochondrial_physio1.01608992
35MP0009764_decreased_sensitivity_to1.01140346
36MP0005084_abnormal_gallbladder_morpholo1.01060697
37MP0009697_abnormal_copulation0.96727830
38MP0005670_abnormal_white_adipose0.96046160
39MP0003011_delayed_dark_adaptation0.93663844
40MP0005647_abnormal_sex_gland0.93341842
41MP0003656_abnormal_erythrocyte_physiolo0.91587190
42MP0009642_abnormal_blood_homeostasis0.89885937
43MP0010155_abnormal_intestine_physiology0.89425537
44MP0003705_abnormal_hypodermis_morpholog0.88011137
45MP0000604_amyloidosis0.87477921
46MP0005535_abnormal_body_temperature0.84068539
47MP0008469_abnormal_protein_level0.83192167
48MP0000566_synostosis0.80882078
49MP0005408_hypopigmentation0.80727236
50MP0009763_increased_sensitivity_to0.79692784
51MP0001661_extended_life_span0.76756224
52MP0005220_abnormal_exocrine_pancreas0.75819101
53MP0002078_abnormal_glucose_homeostasis0.75299102
54MP0002928_abnormal_bile_duct0.75088265
55MP0009780_abnormal_chondrocyte_physiolo0.73467721
56MP0005058_abnormal_lysosome_morphology0.71971925
57MP0005376_homeostasis/metabolism_phenot0.70944377
58MP0000678_abnormal_parathyroid_gland0.68887156
59MP0002254_reproductive_system_inflammat0.68235536
60MP0009765_abnormal_xenobiotic_induced0.68119159
61MP0001915_intracranial_hemorrhage0.65216564
62MP0001881_abnormal_mammary_gland0.64574251
63MP0002971_abnormal_brown_adipose0.64304840
64MP0001873_stomach_inflammation0.63611627
65MP0006035_abnormal_mitochondrial_morpho0.62037066
66MP0002168_other_aberrant_phenotype0.60604696
67MP0000230_abnormal_systemic_arterial0.60362227
68MP0003638_abnormal_response/metabolism_0.60295227
69MP0000538_abnormal_urinary_bladder0.60141542
70MP0005395_other_phenotype0.59247402
71MP0003329_amyloid_beta_deposits0.58907950
72MP0002249_abnormal_larynx_morphology0.58577242
73MP0003693_abnormal_embryo_hatching0.57756853
74MP0010368_abnormal_lymphatic_system0.57095236
75MP0005334_abnormal_fat_pad0.56684400
76MP0005266_abnormal_metabolism0.56661994
77MP0005666_abnormal_adipose_tissue0.56400343
78MP0002282_abnormal_trachea_morphology0.54628539
79MP0000467_abnormal_esophagus_morphology0.54164032
80MP0003690_abnormal_glial_cell0.52696697
81MP0008961_abnormal_basal_metabolism0.52161137
82MP0009053_abnormal_anal_canal0.52092607
83MP0004130_abnormal_muscle_cell0.51827643
84MP0001545_abnormal_hematopoietic_system0.50003156
85MP0005397_hematopoietic_system_phenotyp0.50003156
86MP0003300_gastrointestinal_ulcer0.49396504
87MP0002135_abnormal_kidney_morphology0.48908266
88MP0000477_abnormal_intestine_morphology0.48636959
89MP0003183_abnormal_peptide_metabolism0.48479335
90MP0002796_impaired_skin_barrier0.45362012
91MP0003953_abnormal_hormone_level0.44980639
92MP0010352_gastrointestinal_tract_polyps0.44891302
93MP0004264_abnormal_extraembryonic_tissu0.43879343
94MP0004957_abnormal_blastocyst_morpholog0.42880316
95MP0009379_abnormal_foot_pigmentation0.41681354
96MP0009333_abnormal_splenocyte_physiolog0.41421377
97MP0003866_abnormal_defecation0.41111317
98MP0005187_abnormal_penis_morphology0.40634346
99MP0003878_abnormal_ear_physiology0.40620851
100MP0005377_hearing/vestibular/ear_phenot0.40620851
101MP0003724_increased_susceptibility_to0.38343168
102MP0008874_decreased_physiological_sensi0.37625857
103MP0001727_abnormal_embryo_implantation0.36947120
104MP0002277_abnormal_respiratory_mucosa0.36773759
105MP0004185_abnormal_adipocyte_glucose0.36525921
106MP0009672_abnormal_birth_weight0.36521691
107MP0005023_abnormal_wound_healing0.36437789
108MP0005448_abnormal_energy_balance0.36244212
109MP0008872_abnormal_physiological_respon0.36103670
110MP0005166_decreased_susceptibility_to0.35794999
111MP0003075_altered_response_to0.35789184
112MP0010234_abnormal_vibrissa_follicle0.35142100
113MP0000858_altered_metastatic_potential0.35079390
114MP0003718_maternal_effect0.34903364
115MP0004147_increased_porphyrin_level0.34900953
116MP0008873_increased_physiological_sensi0.34566255
117MP0000490_abnormal_crypts_of0.34533474
118MP0002098_abnormal_vibrissa_morphology0.34401495
119MP0001730_embryonic_growth_arrest0.33578340
120MP0005165_increased_susceptibility_to0.33118290
121MP0003959_abnormal_lean_body0.32662410
122MP0000639_abnormal_adrenal_gland0.32427620
123MP0004782_abnormal_surfactant_physiolog0.30890931
124MP0002837_dystrophic_cardiac_calcinosis0.27885724
125MP0001958_emphysema0.27416695
126MP0009115_abnormal_fat_cell0.27409745
127MP0001845_abnormal_inflammatory_respons0.26741076
128MP0005464_abnormal_platelet_physiology0.26736926
129MP0002822_catalepsy0.25360203
130MP0004885_abnormal_endolymph0.24766804
131MP0009384_cardiac_valve_regurgitation0.24745023

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.45720780
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.08641974
3Intrahepatic cholestasis (HP:0001406)5.98446899
4Deep venous thrombosis (HP:0002625)5.62923080
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.47723931
6Xanthomatosis (HP:0000991)5.38311970
7Abnormality of glutamine family amino acid metabolism (HP:0010902)5.10816705
8Abnormal respiratory motile cilium physiology (HP:0012261)5.07830315
9Hyperglycinuria (HP:0003108)5.07042409
10Abnormal respiratory motile cilium morphology (HP:0005938)5.01371126
11Abnormal respiratory epithelium morphology (HP:0012253)5.01371126
12Rhinitis (HP:0012384)4.86757614
13Hypobetalipoproteinemia (HP:0003563)4.82505640
14Prolonged partial thromboplastin time (HP:0003645)4.76517827
15Dynein arm defect of respiratory motile cilia (HP:0012255)4.74999722
16Absent/shortened dynein arms (HP:0200106)4.74999722
17Gout (HP:0001997)4.74364196
18Abnormal ciliary motility (HP:0012262)4.74080131
19Abnormality of serine family amino acid metabolism (HP:0010894)4.68174720
20Abnormality of glycine metabolism (HP:0010895)4.68174720
21Ketosis (HP:0001946)4.63394183
22Hyperglycinemia (HP:0002154)4.55050042
23Hyperammonemia (HP:0001987)4.53766380
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.38104525
25Glomerulonephritis (HP:0000099)4.23736692
26Hyperlipoproteinemia (HP:0010980)4.21113176
27Abnormality of sulfur amino acid metabolism (HP:0004339)4.16168956
28Complement deficiency (HP:0004431)3.92659856
29Ketoacidosis (HP:0001993)3.91694338
30Chronic bronchitis (HP:0004469)3.91008869
31Abnormality of purine metabolism (HP:0004352)3.88522298
32Abnormality of fatty-acid metabolism (HP:0004359)3.84955284
33Joint hemorrhage (HP:0005261)3.81065272
34Abnormality of nucleobase metabolism (HP:0010932)3.68003286
35Hypolipoproteinemia (HP:0010981)3.62816742
36Proximal tubulopathy (HP:0000114)3.57884808
37Epidermoid cyst (HP:0200040)3.54370847
38Delayed CNS myelination (HP:0002188)3.53948972
39Hypoglycemic coma (HP:0001325)3.53480478
40Bronchiectasis (HP:0002110)3.48410536
41Abnormality of methionine metabolism (HP:0010901)3.47642641
42Fat malabsorption (HP:0002630)3.44410548
43Hyperuricemia (HP:0002149)3.43891879
44Increased purine levels (HP:0004368)3.43891879
45Alkalosis (HP:0001948)3.39599630
46Abnormality of the common coagulation pathway (HP:0010990)3.34663048
47Recurrent gram-negative bacterial infections (HP:0005420)3.32058859
48Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30209733
49Abnormality of pyrimidine metabolism (HP:0004353)3.26965261
50Nasal polyposis (HP:0100582)3.22456010
51Hypoalphalipoproteinemia (HP:0003233)3.20128813
52Hypokalemic alkalosis (HP:0001949)3.18991867
53Generalized aminoaciduria (HP:0002909)3.18734117
54Metabolic acidosis (HP:0001942)3.10953300
55Increased circulating renin level (HP:0000848)3.06546909
56Conjugated hyperbilirubinemia (HP:0002908)3.05774566
57Abnormality of serum amino acid levels (HP:0003112)3.05170025
58Nephritis (HP:0000123)3.03740536
59Vascular calcification (HP:0004934)2.99405692
60Dicarboxylic aciduria (HP:0003215)2.98484956
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.98484956
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.98476294
63Hyperactive renin-angiotensin system (HP:0000841)2.96606903
64Metabolic alkalosis (HP:0200114)2.88439334
65Hyperbilirubinemia (HP:0002904)2.87676136
66Lethargy (HP:0001254)2.84692332
67Hepatocellular carcinoma (HP:0001402)2.83060041
68Abnormality of complement system (HP:0005339)2.78527453
69Abnormality of the intrinsic pathway (HP:0010989)2.78245055
70Abnormality of urine glucose concentration (HP:0011016)2.76294421
71Glycosuria (HP:0003076)2.76294421
72Hypercholesterolemia (HP:0003124)2.74164395
73Abnormal urine output (HP:0012590)2.68638145
74Malnutrition (HP:0004395)2.68340891
75Hemorrhage of the eye (HP:0011885)2.67383899
76Cardiovascular calcification (HP:0011915)2.65038979
77Abnormality of proline metabolism (HP:0010907)2.63431678
78Hydroxyprolinuria (HP:0003080)2.63431678
79Hypomagnesemia (HP:0002917)2.60594055
80Polyuria (HP:0000103)2.58578697
81Enlarged kidneys (HP:0000105)2.57821243
82Abnormality of the nasal mucosa (HP:0000433)2.56005687
83Vomiting (HP:0002013)2.54517058
84Steatorrhea (HP:0002570)2.54386011
85Rickets (HP:0002748)2.52238541
86Abnormality of chloride homeostasis (HP:0011422)2.52012234
87Irritability (HP:0000737)2.49866245
88Abnormality of renal excretion (HP:0011036)2.45138489
89Spastic diplegia (HP:0001264)2.43661478
90Neonatal onset (HP:0003623)2.43181988
91Cerebral edema (HP:0002181)2.37637796
92Osteomalacia (HP:0002749)2.28971414
93Sensorimotor neuropathy (HP:0007141)2.27502587
94Gingival bleeding (HP:0000225)2.26187878
95Nephrolithiasis (HP:0000787)2.24863852
96Myocardial infarction (HP:0001658)2.21231164
97Late onset (HP:0003584)2.20039567
98Abnormal enzyme/coenzyme activity (HP:0012379)2.20002385
99Systemic lupus erythematosus (HP:0002725)2.19436341
100Purpura (HP:0000979)2.18803970
101Cholecystitis (HP:0001082)2.18433296
102Abnormal gallbladder physiology (HP:0012438)2.18433296
103Renal tubular acidosis (HP:0001947)2.17994788
104Reduced antithrombin III activity (HP:0001976)2.15666596
105Recurrent otitis media (HP:0000403)2.15550453
106Hyperphosphaturia (HP:0003109)2.14726912
107Abnormality of magnesium homeostasis (HP:0004921)2.14328664
108Spontaneous abortion (HP:0005268)2.13163235
109Male infertility (HP:0003251)2.13086577
110Bronchitis (HP:0012387)2.12323091
111Confusion (HP:0001289)2.12048843
112Pancreatitis (HP:0001733)2.11746594
113Increased serum ferritin (HP:0003281)2.11355735
114Recurrent sinusitis (HP:0011108)2.11344702
115Skin nodule (HP:0200036)2.11328552
116Abnormality of vitamin metabolism (HP:0100508)2.09241404
117Thrombophlebitis (HP:0004418)2.08472220
118Hypochromic microcytic anemia (HP:0004840)2.06284911
119Cholelithiasis (HP:0001081)2.05559455
120Hypoglycemic seizures (HP:0002173)2.04616941
121Infertility (HP:0000789)2.04108954
122Hypophosphatemic rickets (HP:0004912)2.03776196
123Mitral stenosis (HP:0001718)2.00449211
124Abnormality of alkaline phosphatase activity (HP:0004379)1.98586262
125Nausea (HP:0002018)1.95027394
126Bifid scrotum (HP:0000048)1.94471818
127Abnormal drinking behavior (HP:0030082)1.92965755
128Polydipsia (HP:0001959)1.92965755
129Acanthocytosis (HP:0001927)1.91961317
130Elevated alkaline phosphatase (HP:0003155)1.91849380
131Flat acetabular roof (HP:0003180)1.91253376
132Abnormality of iron homeostasis (HP:0011031)1.89147115
133Renal salt wasting (HP:0000127)1.88873198
134Esophageal varix (HP:0002040)1.88847590
135Hypophosphatemia (HP:0002148)1.88511893
136Opisthotonus (HP:0002179)1.88252952
137Abnormal gallbladder morphology (HP:0012437)1.86667257
138Abnormal biliary tract physiology (HP:0012439)1.84498787
139Bile duct proliferation (HP:0001408)1.84498787
140Abnormality of the Achilles tendon (HP:0005109)1.82178036
141Poikilocytosis (HP:0004447)1.78677488
142Increased serum pyruvate (HP:0003542)1.75229295
143Abnormality of transition element cation homeostasis (HP:0011030)1.73354393
144Reticulocytosis (HP:0001923)1.72975617
145Abnormal tarsal ossification (HP:0008369)1.72428604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.68014952
2WNK35.19028737
3WNK44.77540998
4OXSR14.25197681
5FGFR43.62993394
6MST43.60424981
7SCYL23.47379415
8EPHA23.44415101
9ERN13.16965961
10EEF2K3.10997625
11SIK13.06056315
12SMG12.57787235
13TTK2.54524497
14PBK2.46001957
15INSRR2.31593459
16EIF2AK12.26707369
17MST1R2.18532337
18STK38L2.14750283
19ERBB42.10193776
20MAPKAPK32.03366998
21STK391.94623243
22RPS6KB21.90284313
23TAOK31.78603969
24MAP2K41.64682626
25NME11.63107156
26TSSK61.60622771
27NME21.58906611
28MAPK111.58903617
29PKN21.43971532
30PDK31.41325556
31PDK41.41325556
32PINK11.38322543
33PIK3CA1.36310758
34SGK2231.36043491
35SGK4941.36043491
36SRPK11.35298197
37ICK1.30835228
38LATS11.29538584
39TRIB31.27949278
40ABL21.25584172
41FRK1.24341836
42PIK3CG1.20561736
43GRK61.17954075
44MAP3K71.17943929
45PTK61.17372153
46MAP3K121.15077075
47NEK61.15042279
48NEK11.14921047
49SGK31.09817932
50FLT31.09300302
51DAPK21.07586068
52PIM21.07515479
53TYK21.06025209
54EIF2AK31.02775463
55PRKAA21.01491829
56SGK21.01157729
57STK161.00749130
58MAP3K30.99740007
59BRSK20.97642835
60NEK90.94870113
61PRPF4B0.91189294
62PDK20.91035203
63JAK20.90083893
64EPHB10.88337345
65GSK3A0.87520060
66TIE10.87035133
67KDR0.85495905
68MAP2K30.83189411
69CDC70.82582333
70PRKCZ0.80579841
71FGFR20.80042580
72DYRK1B0.79984495
73CDK120.79763576
74PRKAA10.79301642
75MAP3K140.78778730
76MAPK150.77724286
77STK380.76814399
78ACVR1B0.76338061
79MET0.75830992
80MAP3K100.75516937
81TRPM70.74577995
82MAP2K20.72890029
83ERBB20.69660415
84TGFBR20.67042348
85MAPK40.66338771
86PTK20.66210479
87PRKACG0.62568100
88PDPK10.61436681
89CDK70.60664052
90MAPKAPK50.60640746
91PRKCI0.59808297
92MAP3K80.58222819
93RIPK10.58189218
94MAP3K110.57095260
95RET0.56951181
96MAPK120.56875632
97CSNK1E0.56162002
98CSNK2A20.55992712
99JAK10.55990333
100AKT20.55863691
101TBK10.55847090
102BMPR20.55597161
103STK240.54879407
104RPS6KB10.54291346
105CDK40.54034725
106TESK20.53949756
107AURKA0.52751708
108IRAK30.49857981
109CDK60.48702528
110PAK40.47994338
111MAP2K60.47076362
112CSK0.46903540
113ALK0.45743526
114ATR0.45733915
115CAMK2G0.45280054
116PLK10.43233385
117STK100.42257391
118ILK0.41957839
119CSNK2A10.41477694
120MAP3K10.41428439
121WNK10.41283016
122AURKB0.41168334
123CHEK20.40528948
124PDK10.38694075
125LRRK20.36676402
126PAK30.36642249
127RAF10.36122343
128PRKG20.34210090
129CHEK10.34020932
130KSR20.33826045
131IRAK20.33170073
132CAMK1D0.33064589
133PRKCQ0.32738952
134CSNK1G10.32369577
135MATK0.32026255
136EPHA40.30155965
137TAOK20.28980448
138IGF1R0.28896214
139BCR0.27760702
140MTOR0.27587856
141MAPK70.27499100
142FGFR30.27264633
143PRKCG0.26249141
144SGK10.24736871
145PRKCA0.24719113
146MAP3K20.24271988
147EPHA30.23576615
148MAP3K60.23449539
149MAP2K10.23343287
150IRAK10.23163454
151CAMK40.22982982
152MAP3K50.21635566
153GRK10.20959168
154FER0.20917011
155EGFR0.18490495
156IKBKE0.18482142
157BMX0.17685135
158CSF1R0.17181305
159PRKCD0.16433254

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.89748455
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.50858142
3Nitrogen metabolism_Homo sapiens_hsa009103.13216289
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12254067
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93071725
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74535099
7Arginine biosynthesis_Homo sapiens_hsa002202.74194058
8Tryptophan metabolism_Homo sapiens_hsa003802.73588335
9Butanoate metabolism_Homo sapiens_hsa006502.69831034
10Fatty acid degradation_Homo sapiens_hsa000712.64025155
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58659058
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54499313
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.50728791
14Propanoate metabolism_Homo sapiens_hsa006402.36594049
15* Peroxisome_Homo sapiens_hsa041462.24270703
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20996475
17Complement and coagulation cascades_Homo sapiens_hsa046102.12614071
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01321556
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93261488
20Fatty acid metabolism_Homo sapiens_hsa012121.93013846
21beta-Alanine metabolism_Homo sapiens_hsa004101.88721722
22Histidine metabolism_Homo sapiens_hsa003401.76402610
23* PPAR signaling pathway_Homo sapiens_hsa033201.74632895
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.72274667
25Chemical carcinogenesis_Homo sapiens_hsa052041.71024406
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70308831
27Pyruvate metabolism_Homo sapiens_hsa006201.70224466
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68432669
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64708600
30Bile secretion_Homo sapiens_hsa049761.63711742
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61653493
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.57070696
33Selenocompound metabolism_Homo sapiens_hsa004501.56024263
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53315905
35Sulfur metabolism_Homo sapiens_hsa009201.50853231
36Retinol metabolism_Homo sapiens_hsa008301.48178037
37Phenylalanine metabolism_Homo sapiens_hsa003601.43858415
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33862296
39Carbon metabolism_Homo sapiens_hsa012001.33728850
40Starch and sucrose metabolism_Homo sapiens_hsa005001.30770502
41Caffeine metabolism_Homo sapiens_hsa002321.28557696
42Fatty acid elongation_Homo sapiens_hsa000621.27515868
43Vitamin digestion and absorption_Homo sapiens_hsa049771.27464491
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.25135096
45Staphylococcus aureus infection_Homo sapiens_hsa051501.24613990
46Biosynthesis of amino acids_Homo sapiens_hsa012301.22592784
47Tyrosine metabolism_Homo sapiens_hsa003501.21261492
48Folate biosynthesis_Homo sapiens_hsa007901.19533705
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12370781
50Arginine and proline metabolism_Homo sapiens_hsa003301.11701352
51ABC transporters_Homo sapiens_hsa020101.05136281
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03180836
53Lysine degradation_Homo sapiens_hsa003101.01443555
54Steroid biosynthesis_Homo sapiens_hsa001000.96245483
55Glutathione metabolism_Homo sapiens_hsa004800.94052332
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.93512714
57Fat digestion and absorption_Homo sapiens_hsa049750.90163639
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85170636
59Sulfur relay system_Homo sapiens_hsa041220.84298498
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83412361
61Glycerolipid metabolism_Homo sapiens_hsa005610.78004949
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77008873
63Vitamin B6 metabolism_Homo sapiens_hsa007500.66094278
64Pentose phosphate pathway_Homo sapiens_hsa000300.60982405
65One carbon pool by folate_Homo sapiens_hsa006700.59823427
66Metabolic pathways_Homo sapiens_hsa011000.51073633
67Fructose and mannose metabolism_Homo sapiens_hsa000510.41734707
68Fatty acid biosynthesis_Homo sapiens_hsa000610.32709672
69Galactose metabolism_Homo sapiens_hsa000520.24351977
70Systemic lupus erythematosus_Homo sapiens_hsa053220.22843162
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21734635
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19885272
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.19513095
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13748233
75* Insulin resistance_Homo sapiens_hsa049310.12892592
76Prion diseases_Homo sapiens_hsa050200.11405420
77Pertussis_Homo sapiens_hsa051330.10647275
78Sphingolipid metabolism_Homo sapiens_hsa006000.09340780
79Protein digestion and absorption_Homo sapiens_hsa049740.07460253
80Glucagon signaling pathway_Homo sapiens_hsa049220.07225836
81Mineral absorption_Homo sapiens_hsa049780.07222074
82DNA replication_Homo sapiens_hsa030300.06134953
83Renin-angiotensin system_Homo sapiens_hsa046140.06076758
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.05832070
85N-Glycan biosynthesis_Homo sapiens_hsa005100.04810530
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04363481
87Linoleic acid metabolism_Homo sapiens_hsa005910.04262712
88AMPK signaling pathway_Homo sapiens_hsa041520.02299523
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.02154907
90Pyrimidine metabolism_Homo sapiens_hsa002400.01542189
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00798779
92Collecting duct acid secretion_Homo sapiens_hsa049660.00726418
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.00088890
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1876158
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1837216
96Oxidative phosphorylation_Homo sapiens_hsa00190-0.1632050
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.1615502
98Insulin signaling pathway_Homo sapiens_hsa04910-0.1532882
99Hepatitis C_Homo sapiens_hsa05160-0.1506658
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1465532
101Regulation of autophagy_Homo sapiens_hsa04140-0.1460465
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1379934
103Amoebiasis_Homo sapiens_hsa05146-0.1226561
104Base excision repair_Homo sapiens_hsa03410-0.1139407
105Lysosome_Homo sapiens_hsa04142-0.0943676
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008-0.0681199
107Huntingtons disease_Homo sapiens_hsa05016-0.0679923
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0608164
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0520494
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0359528
111Mismatch repair_Homo sapiens_hsa03430-0.0344716
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0213015
113Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0111187
114Other glycan degradation_Homo sapiens_hsa00511-0.0037113

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