SLC27A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.81298884
2regulation of posttranscriptional gene silencing (GO:0060147)4.95119295
3regulation of gene silencing by miRNA (GO:0060964)4.95119295
4regulation of gene silencing by RNA (GO:0060966)4.95119295
5desmosome organization (GO:0002934)4.90264577
6detection of other organism (GO:0098543)4.79937509
7detection of bacterium (GO:0016045)4.76152199
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.72968928
9response to peptidoglycan (GO:0032494)4.62208463
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.49336192
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.49336192
12modulation by symbiont of host immune response (GO:0052553)4.49336192
13positive regulation by symbiont of host defense response (GO:0052509)4.49336192
14modulation by symbiont of host defense response (GO:0052031)4.49336192
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.49336192
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.47017996
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.42930181
18negative regulation of cell killing (GO:0031342)4.42930181
19establishment of apical/basal cell polarity (GO:0035089)4.37334783
20positive regulation of gamma-delta T cell activation (GO:0046645)4.31071043
21polarized epithelial cell differentiation (GO:0030859)4.27407416
22regulation of hippo signaling (GO:0035330)4.22577339
23neutrophil activation involved in immune response (GO:0002283)4.16058839
24antigen processing and presentation of endogenous antigen (GO:0019883)4.10674317
25establishment or maintenance of monopolar cell polarity (GO:0061339)4.10466811
26establishment of monopolar cell polarity (GO:0061162)4.10466811
27macrophage activation involved in immune response (GO:0002281)4.00111131
28cellular extravasation (GO:0045123)3.93113340
29detection of external biotic stimulus (GO:0098581)3.88694529
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88263254
31C21-steroid hormone biosynthetic process (GO:0006700)3.86350336
32cellular response to interferon-alpha (GO:0035457)3.79643364
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78308362
34leukocyte migration involved in inflammatory response (GO:0002523)3.69241107
35paraxial mesoderm development (GO:0048339)3.68536063
36mannose metabolic process (GO:0006013)3.58922066
37viral transcription (GO:0019083)3.58304103
38immunoglobulin mediated immune response (GO:0016064)3.58171989
39lateral sprouting from an epithelium (GO:0060601)3.58095587
40lung-associated mesenchyme development (GO:0060484)3.52336570
41negative regulation of cell fate specification (GO:0009996)3.48550704
42detection of biotic stimulus (GO:0009595)3.48491700
43outer ear morphogenesis (GO:0042473)3.45197284
44G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.45145150
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43700504
46negative regulation of erythrocyte differentiation (GO:0045647)3.43001904
47translational termination (GO:0006415)3.42421213
48positive regulation of cellular amide metabolic process (GO:0034250)3.40969809
49respiratory burst (GO:0045730)3.40449151
50response to muramyl dipeptide (GO:0032495)3.39038492
51regulation of gamma-delta T cell activation (GO:0046643)3.36691620
52interferon-gamma secretion (GO:0072643)3.29392320
53negative regulation of interleukin-12 production (GO:0032695)3.29145763
54leukocyte aggregation (GO:0070486)3.27780895
55detection of molecule of bacterial origin (GO:0032490)3.26281613
56non-canonical Wnt signaling pathway (GO:0035567)3.24486841
57regulation of interferon-beta biosynthetic process (GO:0045357)3.24056922
58formation of translation preinitiation complex (GO:0001731)3.22623574
59regulation of mast cell degranulation (GO:0043304)3.21246246
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.16353006
61regulation of water loss via skin (GO:0033561)3.15559709
62ribosomal small subunit biogenesis (GO:0042274)3.15483950
63positive regulation of SMAD protein import into nucleus (GO:0060391)3.13975200
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12110553
65regulation of leukocyte degranulation (GO:0043300)3.06370127
66regulation of T-helper 2 cell differentiation (GO:0045628)3.06310335
67maturation of SSU-rRNA (GO:0030490)3.06236849
68positive regulation of antigen processing and presentation (GO:0002579)3.05954171
69establishment of skin barrier (GO:0061436)3.03582295
70negative regulation of lymphocyte mediated immunity (GO:0002707)3.03436249
71positive regulation of mast cell activation (GO:0033005)3.03277725
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.02702693
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.01525632
74pre-miRNA processing (GO:0031054)3.00990706
75notochord development (GO:0030903)3.00380324
76regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00252209
77negative regulation of epidermis development (GO:0045683)2.98977020
78heterochromatin organization (GO:0070828)2.98769650
79amino sugar catabolic process (GO:0046348)2.97993343
80nodal signaling pathway (GO:0038092)2.97929859
81regulation of SMAD protein import into nucleus (GO:0060390)2.96170705
82cell-substrate junction assembly (GO:0007044)2.95325172
83neutrophil activation (GO:0042119)2.94501682
84translational elongation (GO:0006414)2.92124791
85embryonic camera-type eye development (GO:0031076)2.92097762
86cochlea morphogenesis (GO:0090103)2.91535078
87establishment of planar polarity (GO:0001736)2.90255972
88establishment of tissue polarity (GO:0007164)2.90255972
89granulocyte activation (GO:0036230)2.90183497
90macrophage activation (GO:0042116)2.88957528
91mesenchymal to epithelial transition (GO:0060231)2.88512599
92Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.88279750
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.87089395
94translational initiation (GO:0006413)2.83964136
95regulation of transforming growth factor beta2 production (GO:0032909)2.83100730
96regulation of mast cell activation involved in immune response (GO:0033006)2.82385508
97trophectodermal cell differentiation (GO:0001829)2.82176518
98regulation of antigen processing and presentation (GO:0002577)2.82122632
99type I interferon signaling pathway (GO:0060337)2.81556142
100cellular response to type I interferon (GO:0071357)2.81556142
101negative regulation of innate immune response (GO:0045824)2.81132737
102response to type I interferon (GO:0034340)2.80862746
103epithelial cell-cell adhesion (GO:0090136)2.80724122
104regulation of establishment of planar polarity (GO:0090175)2.80513495
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.80398102
106spliceosomal tri-snRNP complex assembly (GO:0000244)2.80373801
107glycosphingolipid catabolic process (GO:0046479)2.80115993
108regulation of gamma-delta T cell differentiation (GO:0045586)2.79970694
109eyelid development in camera-type eye (GO:0061029)2.79052702
110response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78913028
111response to host immune response (GO:0052572)2.78913028
112positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76686585
113negative regulation of leukocyte mediated immunity (GO:0002704)2.76374173
114pinocytosis (GO:0006907)2.76299091
115myeloid cell activation involved in immune response (GO:0002275)2.75680440
116androgen biosynthetic process (GO:0006702)2.75567822
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.75554581
118anterior/posterior axis specification, embryo (GO:0008595)2.75516921
119viral life cycle (GO:0019058)2.74679814
120DNA unwinding involved in DNA replication (GO:0006268)2.74206622
121renal system process involved in regulation of blood volume (GO:0001977)2.74164339
122response to laminar fluid shear stress (GO:0034616)2.71886592
123negative regulation of type 2 immune response (GO:0002829)2.71704251
124peptidyl-arginine omega-N-methylation (GO:0035247)2.69997347
125bone trabecula formation (GO:0060346)2.69653839
126positive regulation of mast cell activation involved in immune response (GO:0033008)2.68908927
127positive regulation of mast cell degranulation (GO:0043306)2.68908927
128apoptotic process involved in morphogenesis (GO:0060561)2.67986795
129positive regulation of type 2 immune response (GO:0002830)2.67309285
130regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.67177244
131histone arginine methylation (GO:0034969)2.67111265
132amyloid precursor protein catabolic process (GO:0042987)2.66707705
133positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.66543214
134negative regulation of cell fate commitment (GO:0010454)2.65232012
135cellular protein complex disassembly (GO:0043624)2.65122533
136lipoxygenase pathway (GO:0019372)2.64684691
137adhesion of symbiont to host (GO:0044406)2.64190094
138negative regulation of granulocyte differentiation (GO:0030853)2.64111871
139convergent extension (GO:0060026)2.63971208
140regulation of T cell tolerance induction (GO:0002664)2.63773602
141interferon-gamma-mediated signaling pathway (GO:0060333)2.62721930
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62608065
143regulation of type 2 immune response (GO:0002828)2.62200790
144hippo signaling (GO:0035329)2.62071796
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61663112
146regulation of mast cell activation (GO:0033003)2.60269372
147protein heterotrimerization (GO:0070208)2.59605427
148maternal placenta development (GO:0001893)2.59433114
149protein complex disassembly (GO:0043241)2.59107678
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58874265
151positive thymic T cell selection (GO:0045059)2.58526410
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58249766
153collecting duct development (GO:0072044)2.57967333
154positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57881799
155ectoderm development (GO:0007398)2.57314286
156establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.56225596
157regulation of regulated secretory pathway (GO:1903305)2.55530834
158regulation of cell fate specification (GO:0042659)2.55514710
159digestive tract morphogenesis (GO:0048546)2.54631598
160negative regulation of chondrocyte differentiation (GO:0032331)2.53924991
161positive regulation of cholesterol efflux (GO:0010875)2.53718569
162negative regulation of T cell mediated immunity (GO:0002710)2.53584749
163defense response to protozoan (GO:0042832)2.53173302
164production of molecular mediator involved in inflammatory response (GO:0002532)2.53033782
165barbed-end actin filament capping (GO:0051016)2.52970562
166regulation of male gonad development (GO:2000018)2.52917972
167bone morphogenesis (GO:0060349)2.52826411
168T-helper 1 type immune response (GO:0042088)2.52216518
169regulation of catenin import into nucleus (GO:0035412)2.52021965
170cell surface receptor signaling pathway involved in heart development (GO:0061311)2.51637204
171proximal/distal pattern formation (GO:0009954)2.51110157
172branching involved in salivary gland morphogenesis (GO:0060445)2.51108608
173germinal center formation (GO:0002467)2.51062931
174negative regulation of mRNA processing (GO:0050686)2.50822382
175negative regulation of catenin import into nucleus (GO:0035414)2.50523036
176response to protozoan (GO:0001562)2.50250411
177glucocorticoid biosynthetic process (GO:0006704)2.49861062
178dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49746896
179microglial cell activation (GO:0001774)2.49612132
180B cell mediated immunity (GO:0019724)2.49383860
181cardiac right ventricle morphogenesis (GO:0003215)2.47623734
182response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47403968
183response to host (GO:0075136)2.47403968
184response to host defenses (GO:0052200)2.47403968
185anatomical structure regression (GO:0060033)2.47287672
186positive regulation of tumor necrosis factor production (GO:0032760)2.47099933
187regulation of tolerance induction (GO:0002643)2.46797401
188peptide catabolic process (GO:0043171)2.46319039
189glycolipid catabolic process (GO:0019377)2.45329856
190histone H4-K12 acetylation (GO:0043983)2.45136753
191DNA replication-dependent nucleosome assembly (GO:0006335)2.44390311
192DNA replication-dependent nucleosome organization (GO:0034723)2.44390311
193cell migration involved in gastrulation (GO:0042074)2.43600380
194positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.43444704
195regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43325021
196negative regulation of RNA splicing (GO:0033119)2.43017441
197SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42710319
198peptidyl-arginine methylation (GO:0018216)2.42631096
199peptidyl-arginine N-methylation (GO:0035246)2.42631096
200regulation of mesoderm development (GO:2000380)2.41647565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.10604110
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.29170369
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.55157642
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.52342267
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.52342267
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.52342267
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.27178077
8E2F7_22180533_ChIP-Seq_HELA_Human3.15491555
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.85189477
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60795501
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.59078430
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.53039677
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42329794
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42196203
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.41156570
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.34379619
17VDR_24763502_ChIP-Seq_THP-1_Human2.32570662
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32197755
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29466428
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.24635571
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21268470
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.18913746
23ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18186316
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15404231
25SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.15332676
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.11118177
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06813898
28ZFP281_18757296_ChIP-ChIP_E14_Mouse2.05776984
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04136889
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.99467019
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99416072
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.97210250
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96739506
34ZNF263_19887448_ChIP-Seq_K562_Human1.96400122
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89231569
36TCF3_18692474_ChIP-Seq_MESCs_Mouse1.83925078
37MAF_26560356_Chip-Seq_TH1_Human1.83140577
38SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.80374942
39* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76790740
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.75990673
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.73719294
42KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73238548
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72899450
44SPI1_23127762_ChIP-Seq_K562_Human1.72072211
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.71747438
46UTX_26944678_Chip-Seq_JUKART_Human1.69084299
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67524147
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66816936
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66413230
50* SPI1_23547873_ChIP-Seq_NB4_Human1.64634884
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63911231
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63405966
53* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62839116
54MAF_26560356_Chip-Seq_TH2_Human1.62650140
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62348071
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.60050326
57RXR_22158963_ChIP-Seq_LIVER_Mouse1.60033376
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56622722
59ESR1_21235772_ChIP-Seq_MCF-7_Human1.55585235
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55481338
61* TP53_20018659_ChIP-ChIP_R1E_Mouse1.54747985
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.52217943
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52138238
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52057781
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.52028321
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50164617
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49646569
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49246230
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48894192
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48065907
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.47680669
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47468244
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46662479
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.46538469
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46434786
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46215314
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46147460
78SCL_19346495_ChIP-Seq_HPC-7_Human1.46038421
79BCL6_27268052_Chip-Seq_Bcells_Human1.44894801
80P68_20966046_ChIP-Seq_HELA_Human1.44119088
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42170930
82* SA1_27219007_Chip-Seq_ERYTHROID_Human1.42131085
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42043153
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40937552
85* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39319058
86STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38760562
87* RACK7_27058665_Chip-Seq_MCF-7_Human1.38408499
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38263974
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.38047655
90CLOCK_20551151_ChIP-Seq_293T_Human1.37979522
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37464138
92* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37166015
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37047622
94MYC_22102868_ChIP-Seq_BL_Human1.36682696
95* LXR_22292898_ChIP-Seq_THP-1_Human1.36434502
96SMC4_20622854_ChIP-Seq_HELA_Human1.36083902
97XRN2_22483619_ChIP-Seq_HELA_Human1.34525128
98BCOR_27268052_Chip-Seq_Bcells_Human1.32026296
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29855774
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29809942
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29731263
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.29500074
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28939998
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28828380
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28607928
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28464939
107* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26540295
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26216760
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26075144
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25956310
111* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24118489
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23972174
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.22713436
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22663928
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22077321
116* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21159511
117* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21042395
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20496997
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20336383
120PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20014904
121EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19711944
122* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19268184
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19085485
124MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19029626
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18841022
126E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18589375
127MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18180545
128* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17648446
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17169582
130DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16914274
131SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16366783
132CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16325697
133* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16316934
134TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14911068
135NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14787658
136TET1_21451524_ChIP-Seq_MESCs_Mouse1.14722463
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14171018
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13647606
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13507897
140ATF3_27146783_Chip-Seq_COLON_Human1.13101533
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12031485
142EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11851057
143MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11834095
144* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11596855
145ESR2_21235772_ChIP-Seq_MCF-7_Human1.11435404
146AR_21909140_ChIP-Seq_LNCAP_Human1.10867924
147* ERG_21242973_ChIP-ChIP_JURKAT_Human1.10375876
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08985951
149* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08981991
150KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08331359
151VDR_21846776_ChIP-Seq_THP-1_Human1.08219456
152CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07929989
153* KDM2B_26808549_Chip-Seq_DND41_Human1.07166476
154SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07161439
155* KDM2B_26808549_Chip-Seq_K562_Human1.07097481
156NCOR1_26117541_ChIP-Seq_K562_Human1.06773350
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06290274
158* SA1_27219007_Chip-Seq_Bcells_Human1.04662641
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04599088
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04189533
161CTCF_26484167_Chip-Seq_Bcells_Mouse1.03959594
162RUNX_20019798_ChIP-Seq_JUKART_Human1.02669634
163PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02265915
164NANOG_21062744_ChIP-ChIP_HESCs_Human1.00821693
165FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00651125
166POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00593038
167* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.99365010
168TP53_22127205_ChIP-Seq_IMR90_Human0.99271329
169TTF2_22483619_ChIP-Seq_HELA_Human0.98947510
170* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98717092
171HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93237433
172EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93089797
173TCF7_22412390_ChIP-Seq_EML_Mouse0.92610043
174POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92174568
175NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92127491

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.69277858
2MP0003724_increased_susceptibility_to3.66409234
3MP0003303_peritoneal_inflammation3.60067806
4MP0005058_abnormal_lysosome_morphology3.45034341
5MP0003436_decreased_susceptibility_to3.42653737
6MP0002254_reproductive_system_inflammat3.39826496
7MP0003705_abnormal_hypodermis_morpholog3.33278416
8MP0000537_abnormal_urethra_morphology2.80064401
9MP0002419_abnormal_innate_immunity2.79865923
10MP0005671_abnormal_response_to2.75519934
11MP0003172_abnormal_lysosome_physiology2.70206265
12MP0003191_abnormal_cellular_cholesterol2.63051130
13MP0005275_abnormal_skin_tensile2.60459821
14MP0005025_abnormal_response_to2.52837553
15MP0003941_abnormal_skin_development2.49597178
16MP0006082_CNS_inflammation2.48522102
17MP0001849_ear_inflammation2.48231522
18MP0001835_abnormal_antigen_presentation2.42061259
19MP0001790_abnormal_immune_system2.29742989
20MP0005387_immune_system_phenotype2.29742989
21MP0002796_impaired_skin_barrier2.29720466
22MP0009785_altered_susceptibility_to2.27488757
23MP0008260_abnormal_autophagy2.26915323
24MP0009840_abnormal_foam_cell2.18864287
25MP0010234_abnormal_vibrissa_follicle2.16144136
26MP0009053_abnormal_anal_canal2.14483458
27MP0000762_abnormal_tongue_morphology2.09986200
28MP0002148_abnormal_hypersensitivity_rea2.05600545
29MP0003123_paternal_imprinting2.05048528
30MP0005000_abnormal_immune_tolerance2.00821892
31MP0003566_abnormal_cell_adhesion1.99189701
32MP0005451_abnormal_body_composition1.98346214
33MP0002653_abnormal_ependyma_morphology1.98231680
34MP0001533_abnormal_skeleton_physiology1.96576515
35MP0005076_abnormal_cell_differentiation1.96395619
36MP0003828_pulmonary_edema1.95042214
37MP0004272_abnormal_basement_membrane1.94870717
38MP0003300_gastrointestinal_ulcer1.92948535
39MP0002452_abnormal_antigen_presenting1.85832769
40MP0001800_abnormal_humoral_immune1.85200560
41MP0010352_gastrointestinal_tract_polyps1.84527415
42MP0002723_abnormal_immune_serum1.81140950
43MP0000383_abnormal_hair_follicle1.77862190
44MP0002060_abnormal_skin_morphology1.77660285
45MP0003119_abnormal_digestive_system1.77343512
46MP0000685_abnormal_immune_system1.77068040
47MP0001819_abnormal_immune_cell1.76222046
48MP0003453_abnormal_keratinocyte_physiol1.75892622
49MP0002420_abnormal_adaptive_immunity1.75666819
50MP0004957_abnormal_blastocyst_morpholog1.74342016
51MP0004947_skin_inflammation1.72512520
52MP0001346_abnormal_lacrimal_gland1.69511611
53MP0004133_heterotaxia1.66141641
54MP0000467_abnormal_esophagus_morphology1.65512651
55MP0004381_abnormal_hair_follicle1.64212014
56MP0005257_abnormal_intraocular_pressure1.63599955
57MP0000579_abnormal_nail_morphology1.63503472
58MP0005464_abnormal_platelet_physiology1.62381617
59MP0005501_abnormal_skin_physiology1.60963917
60MP0001958_emphysema1.58769567
61MP0003279_aneurysm1.58029172
62MP0003755_abnormal_palate_morphology1.57628289
63MP0002405_respiratory_system_inflammati1.56895245
64MP0003075_altered_response_to1.55592692
65MP0002249_abnormal_larynx_morphology1.55109687
66MP0002098_abnormal_vibrissa_morphology1.49866150
67MP0000566_synostosis1.49813491
68MP0002998_abnormal_bone_remodeling1.49481172
69MP0000049_abnormal_middle_ear1.48462931
70MP0010155_abnormal_intestine_physiology1.48248992
71MP0000428_abnormal_craniofacial_morphol1.47813146
72MP0003942_abnormal_urinary_system1.47149208
73MP0005503_abnormal_tendon_morphology1.47049451
74MP0003385_abnormal_body_wall1.46571935
75MP0000343_altered_response_to1.46021274
76MP0010678_abnormal_skin_adnexa1.45146979
77MP0001845_abnormal_inflammatory_respons1.44424731
78MP0008438_abnormal_cutaneous_collagen1.42358940
79MP0005508_abnormal_skeleton_morphology1.41237899
80MP0000604_amyloidosis1.39951183
81MP0009333_abnormal_splenocyte_physiolog1.39522205
82MP0002139_abnormal_hepatobiliary_system1.39342817
83MP0002234_abnormal_pharynx_morphology1.39078444
84MP0003690_abnormal_glial_cell1.38976151
85MP0008469_abnormal_protein_level1.38339341
86MP0000516_abnormal_urinary_system1.36859634
87MP0005367_renal/urinary_system_phenotyp1.36859634
88MP0002084_abnormal_developmental_patter1.35870054
89MP0002932_abnormal_joint_morphology1.35034874
90MP0003937_abnormal_limbs/digits/tail_de1.34721748
91MP0000858_altered_metastatic_potential1.34266705
92MP0001216_abnormal_epidermal_layer1.33618061
93MP0009250_abnormal_appendicular_skeleto1.33387370
94MP0003122_maternal_imprinting1.33302235
95MP0002111_abnormal_tail_morphology1.30794571
96MP0005623_abnormal_meninges_morphology1.29749398
97MP0003183_abnormal_peptide_metabolism1.29246298
98MP0000678_abnormal_parathyroid_gland1.28867626
99MP0002282_abnormal_trachea_morphology1.28537569
100MP0008789_abnormal_olfactory_epithelium1.28488587
101MP0005365_abnormal_bile_salt1.28224053
102MP0003121_genomic_imprinting1.28100428
103MP0003283_abnormal_digestive_organ1.28015544
104MP0003111_abnormal_nucleus_morphology1.26297111
105MP0001293_anophthalmia1.26269139
106MP0002085_abnormal_embryonic_tissue1.25427793
107MP0004510_myositis1.25323895
108MP0004197_abnormal_fetal_growth/weight/1.25286446
109MP0002132_abnormal_respiratory_system1.24827624
110MP0005666_abnormal_adipose_tissue1.24673508
111MP0002233_abnormal_nose_morphology1.24036021
112MP0005397_hematopoietic_system_phenotyp1.23886180
113MP0001545_abnormal_hematopoietic_system1.23886180
114MP0003315_abnormal_perineum_morphology1.23563953
115MP0001348_abnormal_lacrimal_gland1.23534054
116MP0001851_eye_inflammation1.23472430
117MP0000716_abnormal_immune_system1.22961222
118MP0005409_darkened_coat_color1.22396916
119MP0009278_abnormal_bone_marrow1.21657765
120MP0000350_abnormal_cell_proliferation1.21453225
121MP0000733_abnormal_muscle_development1.20043298
122MP0002138_abnormal_hepatobiliary_system1.19799395
123MP0000534_abnormal_ureter_morphology1.19465704
124MP0003935_abnormal_craniofacial_develop1.18894978
125MP0005023_abnormal_wound_healing1.18314097
126MP0008004_abnormal_stomach_pH1.18249572
127MP0000647_abnormal_sebaceous_gland1.17071479
128MP0000465_gastrointestinal_hemorrhage1.16939245
129MP0002697_abnormal_eye_size1.15438091
130MP0003890_abnormal_embryonic-extraembry1.13881423
131MP0001340_abnormal_eyelid_morphology1.13090219
132MP0003077_abnormal_cell_cycle1.12957257
133MP0009764_decreased_sensitivity_to1.12425530
134MP0005166_decreased_susceptibility_to1.12191488
135MP0000432_abnormal_head_morphology1.10957241
136MP0000377_abnormal_hair_follicle1.10713787
137MP0003806_abnormal_nucleotide_metabolis1.10291031
138MP0002092_abnormal_eye_morphology1.09101522
139MP0004858_abnormal_nervous_system1.08887192
140MP0005670_abnormal_white_adipose1.07093155
141MP0005167_abnormal_blood-brain_barrier1.05821743
142MP0010771_integument_phenotype1.05664617
143MP0002398_abnormal_bone_marrow1.05272555
144MP0005394_taste/olfaction_phenotype1.04832572
145MP0005499_abnormal_olfactory_system1.04832572
146MP0002116_abnormal_craniofacial_bone1.03824848
147MP0008007_abnormal_cellular_replicative1.02831795
148MP0004264_abnormal_extraembryonic_tissu1.01654670
149MP0002971_abnormal_brown_adipose1.01340929
150MP0001730_embryonic_growth_arrest1.00460916
151MP0004185_abnormal_adipocyte_glucose1.00066571
152MP0005380_embryogenesis_phenotype0.99715001
153MP0001672_abnormal_embryogenesis/_devel0.99715001
154MP0008932_abnormal_embryonic_tissue0.99060272
155MP0002086_abnormal_extraembryonic_tissu0.98820371
156MP0002429_abnormal_blood_cell0.97248137
157MP0003091_abnormal_cell_migration0.97197295
158MP0004883_abnormal_blood_vessel0.96314648
159MP0003448_altered_tumor_morphology0.95264548
160MP0008057_abnormal_DNA_replication0.95151649
161MP0010094_abnormal_chromosome_stability0.94252625
162MP0001853_heart_inflammation0.94003314
163MP0001697_abnormal_embryo_size0.93803922
164MP0003115_abnormal_respiratory_system0.93767039
165MP0000427_abnormal_hair_cycle0.92967157
166MP0000689_abnormal_spleen_morphology0.92502317
167MP0002722_abnormal_immune_system0.90761856
168MP0005390_skeleton_phenotype0.89949937
169MP0000249_abnormal_blood_vessel0.88999979
170MP0004782_abnormal_surfactant_physiolog0.88990004
171MP0003763_abnormal_thymus_physiology0.88952475
172MP0008874_decreased_physiological_sensi0.86866672
173MP0003329_amyloid_beta_deposits0.86710334
174MP0009115_abnormal_fat_cell0.86460934
175MP0005375_adipose_tissue_phenotype0.86451786
176MP0001286_abnormal_eye_development0.85956154
177MP0005310_abnormal_salivary_gland0.85687115
178MP0002114_abnormal_axial_skeleton0.85348105
179MP0002088_abnormal_embryonic_growth/wei0.85346069
180MP0003567_abnormal_fetal_cardiomyocyte0.83125085
181MP0002933_joint_inflammation0.82972484
182MP0003984_embryonic_growth_retardation0.82855689
183MP0010329_abnormal_lipoprotein_level0.81787585
184MP0003786_premature_aging0.81304384
185MP0005377_hearing/vestibular/ear_phenot0.79870070
186MP0003878_abnormal_ear_physiology0.79870070
187MP0005319_abnormal_enzyme/_coenzyme0.79727460
188MP0005075_abnormal_melanosome_morpholog0.79625483
189MP0000371_diluted_coat_color0.79327048
190MP0000767_abnormal_smooth_muscle0.78433899
191MP0003866_abnormal_defecation0.76872712

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.37077282
2Abnormality of macrophages (HP:0004311)5.20000928
3Systemic lupus erythematosus (HP:0002725)4.95097165
4Recurrent abscess formation (HP:0002722)4.90128928
5Recurrent bacterial skin infections (HP:0005406)4.68637458
6Recurrent gram-negative bacterial infections (HP:0005420)4.57115924
7Vacuolated lymphocytes (HP:0001922)4.26935287
8Milia (HP:0001056)4.21579039
9Abnormality of liposaccharide metabolism (HP:0010968)4.19811433
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.19811433
11Abnormality of glycolipid metabolism (HP:0010969)4.19811433
12Atrophic scars (HP:0001075)3.98424058
13Increased cerebral lipofuscin (HP:0011813)3.94834106
14Fragile nails (HP:0001808)3.94676296
15Myositis (HP:0100614)3.68126213
16Loss of speech (HP:0002371)3.55046349
17Selective tooth agenesis (HP:0001592)3.50686632
18Dysostosis multiplex (HP:0000943)3.48021824
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.41184260
20Orchitis (HP:0100796)3.37392170
21Mediastinal lymphadenopathy (HP:0100721)3.20688424
22Amyloidosis (HP:0011034)3.16875160
23Recurrent skin infections (HP:0001581)3.16340338
24Chronic obstructive pulmonary disease (HP:0006510)3.10002063
25Obstructive lung disease (HP:0006536)3.10002063
26Shallow orbits (HP:0000586)3.05589070
27Hypotrichosis (HP:0001006)3.04112438
28Esophageal atresia (HP:0002032)3.01939159
29Abnormality of mucopolysaccharide metabolism (HP:0011020)2.98633334
30Abnormality of polysaccharide metabolism (HP:0011012)2.98633334
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.98633334
32Gingivitis (HP:0000230)2.95600974
33Optic neuritis (HP:0100653)2.93891625
34Retrobulbar optic neuritis (HP:0100654)2.93891625
35Urinary glycosaminoglycan excretion (HP:0003541)2.93172539
36Mucopolysacchariduria (HP:0008155)2.93172539
37Purpura (HP:0000979)2.91553272
38Spontaneous hematomas (HP:0007420)2.89565092
39Abnormal sex determination (HP:0012244)2.85791337
40Sex reversal (HP:0012245)2.85791337
41Protrusio acetabuli (HP:0003179)2.83839001
42Plantar hyperkeratosis (HP:0007556)2.83562337
43Recurrent cutaneous fungal infections (HP:0011370)2.82218661
44Chronic mucocutaneous candidiasis (HP:0002728)2.82218661
45Gastrointestinal infarctions (HP:0005244)2.81666554
46Recurrent fungal infections (HP:0002841)2.81073646
47Meningitis (HP:0001287)2.80337468
48Pili torti (HP:0003777)2.77825852
49Concave nail (HP:0001598)2.77733037
50Thin bony cortex (HP:0002753)2.72700957
51Axonal loss (HP:0003447)2.66110877
52Abnormality of complement system (HP:0005339)2.62858746
53Complement deficiency (HP:0004431)2.62275088
54Hepatosplenomegaly (HP:0001433)2.62259986
55Interstitial pulmonary disease (HP:0006530)2.61308591
56Glomerulonephritis (HP:0000099)2.60896981
57Elevated erythrocyte sedimentation rate (HP:0003565)2.57149382
58Onycholysis (HP:0001806)2.56706036
59Polygenic inheritance (HP:0010982)2.55099261
60Woolly hair (HP:0002224)2.51251541
61Increased IgE level (HP:0003212)2.50882734
62Ankle contracture (HP:0006466)2.48556314
63Hemorrhage of the eye (HP:0011885)2.48344607
64Premature rupture of membranes (HP:0001788)2.46999982
65Hemoptysis (HP:0002105)2.42053164
66Colitis (HP:0002583)2.40931660
67Esophageal varix (HP:0002040)2.37987985
68Stomatitis (HP:0010280)2.36369353
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.35656138
70Deep venous thrombosis (HP:0002625)2.35012529
71Cellulitis (HP:0100658)2.34119013
72Abnormality of the labia minora (HP:0012880)2.33015575
73Fragile skin (HP:0001030)2.32519500
74Myocardial infarction (HP:0001658)2.31395953
75Trismus (HP:0000211)2.30989525
76Malnutrition (HP:0004395)2.30803414
77Urticaria (HP:0001025)2.29676628
78Ependymoma (HP:0002888)2.28048141
79Nail dystrophy (HP:0008404)2.27099210
80Increased connective tissue (HP:0009025)2.26479281
81J-shaped sella turcica (HP:0002680)2.21328465
82Gastrointestinal inflammation (HP:0004386)2.18376810
83Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18348555
84Increased serum ferritin (HP:0003281)2.17761060
85Renal duplication (HP:0000075)2.16284630
86Rib fusion (HP:0000902)2.16250725
87Abnormality of the aortic arch (HP:0012303)2.15965107
88Joint hemorrhage (HP:0005261)2.15092907
89Inflammation of the large intestine (HP:0002037)2.15025679
90Prolonged bleeding time (HP:0003010)2.13849487
91Vasculitis (HP:0002633)2.13675091
92Cerebral aneurysm (HP:0004944)2.13531523
93Gingival bleeding (HP:0000225)2.13493747
94Pathologic fracture (HP:0002756)2.13346152
95Segmental peripheral demyelination/remyelination (HP:0003481)2.11157577
96Hypertriglyceridemia (HP:0002155)2.08293329
97Epistaxis (HP:0000421)2.07682386
98Petechiae (HP:0000967)2.06190611
99Aplasia/hypoplasia of the humerus (HP:0006507)2.05877041
100Chest pain (HP:0100749)2.05576402
101Protuberant abdomen (HP:0001538)2.05173802
102Encephalitis (HP:0002383)2.04975506
103Lip pit (HP:0100267)2.04954260
104Right ventricular cardiomyopathy (HP:0011663)2.03991441
105Pulmonary embolism (HP:0002204)2.03850287
106Keratoconjunctivitis sicca (HP:0001097)2.03078451
107Natal tooth (HP:0000695)2.02981282
108Pterygium (HP:0001059)2.02346965
109Thoracic kyphosis (HP:0002942)2.01505208
110Short humerus (HP:0005792)2.01301432
111Premature loss of primary teeth (HP:0006323)1.99153296
112Pulmonary infiltrates (HP:0002113)1.98153042
113Bilateral microphthalmos (HP:0007633)1.97084350
114Asymmetric septal hypertrophy (HP:0001670)1.96237955
115Neuronal loss in central nervous system (HP:0002529)1.96090176
116Ulnar bowing (HP:0003031)1.95757095
117Distal lower limb muscle weakness (HP:0009053)1.94893712
118Shawl scrotum (HP:0000049)1.94810791
119Colon cancer (HP:0003003)1.94660537
120Atresia of the external auditory canal (HP:0000413)1.94478980
121Abnormality of the peritoneum (HP:0002585)1.94472673
122Orthostatic hypotension (HP:0001278)1.93200165
123Fused cervical vertebrae (HP:0002949)1.92581908
124Nuclear cataract (HP:0100018)1.91424538
125Stenosis of the external auditory canal (HP:0000402)1.91066445
126Turricephaly (HP:0000262)1.90513791
127Genu recurvatum (HP:0002816)1.89362653
128Gastrointestinal atresia (HP:0002589)1.89299095
129Pustule (HP:0200039)1.88328507
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87349365
131Periauricular skin pits (HP:0100277)1.87274889
132Preauricular pit (HP:0004467)1.87274889
133Enlarged penis (HP:0000040)1.85718045
134Missing ribs (HP:0000921)1.85214001
135Upper motor neuron abnormality (HP:0002127)1.84217557
136Advanced eruption of teeth (HP:0006288)1.84027063
137Polycythemia (HP:0001901)1.83706796
138Neonatal short-limb short stature (HP:0008921)1.82218718
139Skin pits (HP:0100276)1.82204034
140Vertebral compression fractures (HP:0002953)1.82062492
141Short 4th metacarpal (HP:0010044)1.82044173
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82044173
143Coronal craniosynostosis (HP:0004440)1.81951893
144Down-sloping shoulders (HP:0200021)1.81633517
145Sparse scalp hair (HP:0002209)1.81044377
146Mesangial abnormality (HP:0001966)1.80464311
147Keratoconjunctivitis (HP:0001096)1.79601048
148Progressive neurologic deterioration (HP:0002344)1.79427877
149Arterial thrombosis (HP:0004420)1.78962770
150Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78022542
151Abnormal delayed hypersensitivity skin test (HP:0002963)1.76980836
152Partial duplication of the phalanx of hand (HP:0009999)1.76731175
153Abnormality of the astrocytes (HP:0100707)1.76606356
154Astrocytoma (HP:0009592)1.76606356
155Disinhibition (HP:0000734)1.76213828
156Anorexia (HP:0002039)1.75519707
157Increased CSF protein (HP:0002922)1.74890037
158Aplasia cutis congenita (HP:0001057)1.74163159
159Alopecia of scalp (HP:0002293)1.73531111
160Abnormality of iron homeostasis (HP:0011031)1.73361222
161Xanthomatosis (HP:0000991)1.73344654
162Broad toe (HP:0001837)1.73030522
163Alacrima (HP:0000522)1.72480037
164Abnormal blistering of the skin (HP:0008066)1.71933564
165Hypoplastic labia majora (HP:0000059)1.71739029
166Sparse eyelashes (HP:0000653)1.70492491
167Vertebral fusion (HP:0002948)1.70411503
168Abnormality of the salivary glands (HP:0010286)1.69563848
169Breech presentation (HP:0001623)1.67751817
170Abnormality of the lower motor neuron (HP:0002366)1.66559929
171Bladder diverticulum (HP:0000015)1.65939169
172Deviation of the hallux (HP:0010051)1.64809354
173Bronchomalacia (HP:0002780)1.64727936
174Palmoplantar hyperkeratosis (HP:0000972)1.63073080
175Broad thumb (HP:0011304)1.62998202
176Preauricular skin tag (HP:0000384)1.60946800
177Ridged nail (HP:0001807)1.60926100
178Facial cleft (HP:0002006)1.60787960
179Ankyloglossia (HP:0010296)1.60320963
180Partial duplication of thumb phalanx (HP:0009944)1.60287880
181Palmar hyperkeratosis (HP:0010765)1.59581123
182Short 5th finger (HP:0009237)1.59488972
183Hallux valgus (HP:0001822)1.59095464
184Premature ovarian failure (HP:0008209)1.59077306
185Abnormal number of incisors (HP:0011064)1.58522283
186Peritonitis (HP:0002586)1.58514378
187Abnormality of the 4th metacarpal (HP:0010012)1.57514584
188Abnormal umbilical cord blood vessels (HP:0011403)1.57113707
189Single umbilical artery (HP:0001195)1.57113707
190Abnormality of the fetal cardiovascular system (HP:0010948)1.57113707
191Skin tags (HP:0010609)1.56248289
192Abnormality of dentin (HP:0010299)1.56203999
193Short 1st metacarpal (HP:0010034)1.55786896
194Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55786896
195Abnormality of the 2nd finger (HP:0004100)1.55224274
196Wrist flexion contracture (HP:0001239)1.55051343
197Reticulocytopenia (HP:0001896)1.53553789
198Short phalanx of the thumb (HP:0009660)1.53476689
199Difficulty climbing stairs (HP:0003551)1.53358929

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.67000998
2PRPF4B3.28050368
3RIPK43.19391928
4ERN12.85545084
5TRIB32.80986395
6MAP4K12.75896650
7EPHA22.69878215
8EPHB22.64442766
9LATS22.51638751
10TYRO32.50931704
11DDR22.49389921
12MAP3K102.49275329
13RPS6KB22.38897415
14FES2.25280458
15MAPKAPK32.25124545
16CSK2.22536926
17ICK2.22505148
18MAP2K32.19346069
19CDK72.06647344
20PKN21.98124658
21PDGFRA1.92312587
22BUB11.81623752
23PAK41.81484854
24EPHB11.78658446
25IRAK41.77953622
26ZAP701.77674871
27FER1.77450431
28SMG11.77280589
29TNK21.71914085
30TAOK11.71627203
31LATS11.65676908
32TBK11.64620562
33MAP3K131.61731623
34EEF2K1.60101947
35TAOK21.52019384
36FGFR21.43138390
37RIPK11.41686911
38MAP3K141.41598591
39JAK31.40130771
40KDR1.38104525
41NEK21.33907010
42FGR1.30528954
43PTK61.30199088
44SIK11.29550923
45MAPK151.28822086
46PTK21.27719541
47MARK21.27659828
48DYRK21.26619186
49CDC42BPA1.26615581
50PRKD21.24823971
51WEE11.24052731
52MTOR1.22674821
53TTK1.22062215
54BMX1.21566955
55FGFR11.18422515
56CSF1R1.17596256
57DYRK31.17137933
58DYRK1B1.16846211
59LRRK21.16280463
60MAP3K11.15823421
61HCK1.14741441
62BTK1.08105855
63FGFR41.07849901
64PDPK11.06583704
65MAP3K61.06457612
66IKBKE1.06041335
67ERBB31.04117619
68IRAK30.98287391
69TTN0.96595213
70RPS6KA40.96169287
71STK100.95929420
72MAP3K30.94637038
73CDC70.93393770
74BCR0.93269137
75AURKA0.92213616
76TGFBR10.91990238
77MET0.91578850
78TIE10.90742637
79PRKCI0.90066469
80PAK20.89798273
81LYN0.88951890
82PLK10.87563459
83JAK20.87160918
84MAP3K90.87028003
85CAMK1D0.86807811
86NEK10.86172251
87KIT0.85391007
88JAK10.84755071
89CDK60.83443139
90ARAF0.83264130
91SIK30.81778193
92KSR20.81636869
93SYK0.80132636
94MAP2K20.79970220
95TSSK60.79595762
96TESK10.78938942
97MAPK120.77765173
98RPS6KA10.77111900
99NTRK20.75949315
100PDK10.75928180
101LCK0.75582162
102ALK0.75511253
103AURKB0.73287169
104MATK0.72811617
105CHEK10.72249737
106MAP3K80.70839546
107PIM20.68686242
108MAPK70.67873927
109MAP3K110.67492943
110MST1R0.67472630
111MOS0.67461274
112IKBKB0.67311601
113YES10.66562108
114TLK10.65811300
115ERBB20.65733122
116KSR10.64094871
117IRAK20.63783159
118RPS6KA60.63540436
119NME20.63067393
120CHEK20.62992632
121AKT20.60893866
122CHUK0.60311657
123PASK0.60251621
124BLK0.59286360
125CDK20.58948353
126GRK70.58280595
127AKT30.56958543
128PAK10.56110158
129MAP3K70.54899449
130ILK0.54220522
131STK38L0.53738974
132ATR0.53445347
133ITK0.53419413
134CAMKK10.53096309
135CDK40.53066979
136CSNK1E0.52906704
137TYK20.52758869
138GSK3A0.52399427
139SIK20.52029448
140TESK20.51447824
141HIPK20.50883173
142PRKG20.50081213
143PRKD10.49606726
144RET0.49573048
145MAPKAPK20.49300800
146STK30.48640482
147TGFBR20.47243805
148GRK60.47174332
149EPHA30.47130247
150FYN0.46845551
151SCYL20.45651430
152RPS6KL10.42303003
153RPS6KC10.42303003
154ABL20.40651037
155MARK30.40544290
156MAP3K20.39701977
157RPS6KA20.38338373
158MAPK40.37728516
159MAPK10.37300545
160BRD40.36093676
161LIMK10.35336391
162MAP2K60.35211814
163CDK190.33415741

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.50309691
2Staphylococcus aureus infection_Homo sapiens_hsa051503.41927059
3Other glycan degradation_Homo sapiens_hsa005113.32290595
4Hedgehog signaling pathway_Homo sapiens_hsa043402.94759093
5Ribosome_Homo sapiens_hsa030102.89696975
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85293078
7Hippo signaling pathway_Homo sapiens_hsa043902.83137167
8Leishmaniasis_Homo sapiens_hsa051402.64575011
9Osteoclast differentiation_Homo sapiens_hsa043802.57418532
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.47517404
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.38530709
12Lysosome_Homo sapiens_hsa041422.33126402
13Spliceosome_Homo sapiens_hsa030402.28653532
14Notch signaling pathway_Homo sapiens_hsa043302.20714726
15RNA transport_Homo sapiens_hsa030132.12057423
16Tuberculosis_Homo sapiens_hsa051522.08393491
17ECM-receptor interaction_Homo sapiens_hsa045122.05804364
18Small cell lung cancer_Homo sapiens_hsa052222.01179663
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95008366
20Allograft rejection_Homo sapiens_hsa053301.92825692
21p53 signaling pathway_Homo sapiens_hsa041151.83574720
22DNA replication_Homo sapiens_hsa030301.82914397
23Graft-versus-host disease_Homo sapiens_hsa053321.78239192
24Adherens junction_Homo sapiens_hsa045201.77475646
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74229507
26Bladder cancer_Homo sapiens_hsa052191.73048468
27TGF-beta signaling pathway_Homo sapiens_hsa043501.71121938
28Base excision repair_Homo sapiens_hsa034101.70204970
29Cell cycle_Homo sapiens_hsa041101.68200076
30Mismatch repair_Homo sapiens_hsa034301.67633721
31Complement and coagulation cascades_Homo sapiens_hsa046101.66821694
32Malaria_Homo sapiens_hsa051441.65827137
33MicroRNAs in cancer_Homo sapiens_hsa052061.65180453
34Hematopoietic cell lineage_Homo sapiens_hsa046401.65115162
35Proteoglycans in cancer_Homo sapiens_hsa052051.63763475
36Phagosome_Homo sapiens_hsa041451.63494307
37Autoimmune thyroid disease_Homo sapiens_hsa053201.61963368
38Pertussis_Homo sapiens_hsa051331.61800688
39B cell receptor signaling pathway_Homo sapiens_hsa046621.58772307
40mRNA surveillance pathway_Homo sapiens_hsa030151.52434659
41Wnt signaling pathway_Homo sapiens_hsa043101.48341691
42Focal adhesion_Homo sapiens_hsa045101.45091505
43HTLV-I infection_Homo sapiens_hsa051661.42072165
44Thyroid cancer_Homo sapiens_hsa052161.39423666
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.38614694
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37830339
47Pathways in cancer_Homo sapiens_hsa052001.36783083
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35289032
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33517026
50Chemokine signaling pathway_Homo sapiens_hsa040621.31733460
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30339950
52Asthma_Homo sapiens_hsa053101.27547380
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24914908
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23859263
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21626779
56Tight junction_Homo sapiens_hsa045301.19276856
57Axon guidance_Homo sapiens_hsa043601.18963714
58Rheumatoid arthritis_Homo sapiens_hsa053231.18049153
59mTOR signaling pathway_Homo sapiens_hsa041501.16954815
60Amoebiasis_Homo sapiens_hsa051461.16222038
61Type I diabetes mellitus_Homo sapiens_hsa049401.14730317
62Melanogenesis_Homo sapiens_hsa049161.13253676
63Colorectal cancer_Homo sapiens_hsa052101.12722648
64NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12584444
65Chronic myeloid leukemia_Homo sapiens_hsa052201.12279794
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09188159
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08637307
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08569333
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07054976
70Endometrial cancer_Homo sapiens_hsa052131.07017308
71Intestinal immune network for IgA production_Homo sapiens_hsa046721.06673055
72Hepatitis C_Homo sapiens_hsa051601.04828990
73NF-kappa B signaling pathway_Homo sapiens_hsa040641.03080859
74One carbon pool by folate_Homo sapiens_hsa006701.02408007
75Central carbon metabolism in cancer_Homo sapiens_hsa052301.01534560
76VEGF signaling pathway_Homo sapiens_hsa043701.01081191
77PPAR signaling pathway_Homo sapiens_hsa033201.01076528
78Fructose and mannose metabolism_Homo sapiens_hsa000511.00640430
79Viral carcinogenesis_Homo sapiens_hsa052030.99886249
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99469442
81Prion diseases_Homo sapiens_hsa050200.97590194
82Prostate cancer_Homo sapiens_hsa052150.97245433
83PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95351981
84Measles_Homo sapiens_hsa051620.94780984
85Protein digestion and absorption_Homo sapiens_hsa049740.94232633
86Toxoplasmosis_Homo sapiens_hsa051450.92402159
87Salmonella infection_Homo sapiens_hsa051320.92059428
88Apoptosis_Homo sapiens_hsa042100.91685573
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91446735
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89585824
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88361796
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88305030
93Viral myocarditis_Homo sapiens_hsa054160.87630903
94Shigellosis_Homo sapiens_hsa051310.85467355
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.84981605
96Galactose metabolism_Homo sapiens_hsa000520.84952328
97Epstein-Barr virus infection_Homo sapiens_hsa051690.84522624
98Nucleotide excision repair_Homo sapiens_hsa034200.82581992
99Herpes simplex infection_Homo sapiens_hsa051680.81556572
100Primary immunodeficiency_Homo sapiens_hsa053400.81422461
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78680661
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78661924
103Melanoma_Homo sapiens_hsa052180.77982080
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77204252
105RNA polymerase_Homo sapiens_hsa030200.74669791
106Pentose phosphate pathway_Homo sapiens_hsa000300.74538479
107Platelet activation_Homo sapiens_hsa046110.74279213
108Oocyte meiosis_Homo sapiens_hsa041140.73751357
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.70533166
110T cell receptor signaling pathway_Homo sapiens_hsa046600.69508315
111Rap1 signaling pathway_Homo sapiens_hsa040150.69367529
112Ovarian steroidogenesis_Homo sapiens_hsa049130.69359456
113African trypanosomiasis_Homo sapiens_hsa051430.69160928
114Acute myeloid leukemia_Homo sapiens_hsa052210.67083205
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66981455
116Legionellosis_Homo sapiens_hsa051340.63866270
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62167314
118Phenylalanine metabolism_Homo sapiens_hsa003600.61840569
119Homologous recombination_Homo sapiens_hsa034400.60816362
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.60546144
121TNF signaling pathway_Homo sapiens_hsa046680.59613028
122Proteasome_Homo sapiens_hsa030500.58910469
123Renal cell carcinoma_Homo sapiens_hsa052110.58307306
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.58107882
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57829700
126Insulin signaling pathway_Homo sapiens_hsa049100.57025911
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.56673026
128* Insulin resistance_Homo sapiens_hsa049310.56388533
129RNA degradation_Homo sapiens_hsa030180.55513308
130Antigen processing and presentation_Homo sapiens_hsa046120.55463010
131Pancreatic cancer_Homo sapiens_hsa052120.54959107
132Estrogen signaling pathway_Homo sapiens_hsa049150.54464018
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53682813
134Prolactin signaling pathway_Homo sapiens_hsa049170.53637301
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53373993
136Non-small cell lung cancer_Homo sapiens_hsa052230.51947329
137ErbB signaling pathway_Homo sapiens_hsa040120.51458371
138Fanconi anemia pathway_Homo sapiens_hsa034600.49055926
139Lysine degradation_Homo sapiens_hsa003100.48537694
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47876873
141Glioma_Homo sapiens_hsa052140.47585384
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.46628006
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.46406327
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45967251
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45352022
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44817437
147Influenza A_Homo sapiens_hsa051640.44107428
148Hepatitis B_Homo sapiens_hsa051610.42861364
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.42313296
150GnRH signaling pathway_Homo sapiens_hsa049120.41875381
151Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41491589
152HIF-1 signaling pathway_Homo sapiens_hsa040660.39951224
153Fatty acid degradation_Homo sapiens_hsa000710.38874497
154Endocytosis_Homo sapiens_hsa041440.38580710
155Arachidonic acid metabolism_Homo sapiens_hsa005900.38284457
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.38114408
157alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38049196
158Dorso-ventral axis formation_Homo sapiens_hsa043200.36969112
159Vibrio cholerae infection_Homo sapiens_hsa051100.36452103
160Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36418457
161Choline metabolism in cancer_Homo sapiens_hsa052310.36374582
162Histidine metabolism_Homo sapiens_hsa003400.35780605
163Systemic lupus erythematosus_Homo sapiens_hsa053220.35388393
164Pyrimidine metabolism_Homo sapiens_hsa002400.34854141
165AMPK signaling pathway_Homo sapiens_hsa041520.34587556

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