SLC27A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.34833931
2Golgi transport vesicle coating (GO:0048200)5.34833931
3intestinal absorption (GO:0050892)4.67619823
4desmosome organization (GO:0002934)4.66771551
5intestinal cholesterol absorption (GO:0030299)4.61218477
6protein localization to endosome (GO:0036010)4.46804079
7proline biosynthetic process (GO:0006561)4.39770050
8protein retention in ER lumen (GO:0006621)4.39349025
9hemidesmosome assembly (GO:0031581)4.38723501
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.24002166
11angiotensin maturation (GO:0002003)4.11806806
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.00512185
13regulation of early endosome to late endosome transport (GO:2000641)3.80398239
14NADH metabolic process (GO:0006734)3.79413956
15regulation of mammary gland epithelial cell proliferation (GO:0033599)3.78117328
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.75737473
17protein maturation by protein folding (GO:0022417)3.64243430
18cell-substrate junction assembly (GO:0007044)3.60376878
19adherens junction assembly (GO:0034333)3.59177500
20activation of Rac GTPase activity (GO:0032863)3.57804195
21regulation of water loss via skin (GO:0033561)3.57246251
22nucleobase catabolic process (GO:0046113)3.55265728
23vocalization behavior (GO:0071625)3.53984109
24urea cycle (GO:0000050)3.52354866
25glucose 6-phosphate metabolic process (GO:0051156)3.48929066
26virion attachment to host cell (GO:0019062)3.47635287
27adhesion of symbiont to host cell (GO:0044650)3.47635287
28focal adhesion assembly (GO:0048041)3.40921005
29cell-substrate adherens junction assembly (GO:0007045)3.40921005
30epithelial cell-cell adhesion (GO:0090136)3.39714687
31negative regulation of cell size (GO:0045792)3.36206325
32apoptotic process involved in morphogenesis (GO:0060561)3.32829026
33skin morphogenesis (GO:0043589)3.32021780
34maternal placenta development (GO:0001893)3.31420895
35urea metabolic process (GO:0019627)3.29552387
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.29396989
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26446294
38proline metabolic process (GO:0006560)3.25026897
39sodium ion export (GO:0071436)3.24383440
40synaptic vesicle maturation (GO:0016188)3.23421685
41locomotory exploration behavior (GO:0035641)3.19784651
42layer formation in cerebral cortex (GO:0021819)3.19654445
43fatty acid elongation (GO:0030497)3.15792663
44barbed-end actin filament capping (GO:0051016)3.13148462
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.13036119
46regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12042183
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07389417
48basement membrane organization (GO:0071711)3.05419642
49cellular potassium ion homeostasis (GO:0030007)3.01601814
50semaphorin-plexin signaling pathway (GO:0071526)3.01580381
51GDP-mannose metabolic process (GO:0019673)3.01301254
52pentose-phosphate shunt (GO:0006098)2.98815808
53regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.98463506
54phospholipid efflux (GO:0033700)2.97207806
55glutamate secretion (GO:0014047)2.94242516
56nitrogen cycle metabolic process (GO:0071941)2.91972047
57establishment of skin barrier (GO:0061436)2.91965958
58actin filament depolymerization (GO:0030042)2.91286561
59glutamine family amino acid biosynthetic process (GO:0009084)2.87317676
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86896728
61glycosphingolipid catabolic process (GO:0046479)2.86079659
62endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.85938161
63glucose catabolic process (GO:0006007)2.83904081
64drug catabolic process (GO:0042737)2.83774152
65regulation of cholesterol biosynthetic process (GO:0045540)2.83010341
66flavonoid metabolic process (GO:0009812)2.80377066
67regulation of cholesterol esterification (GO:0010872)2.80261747
68regulation of translational termination (GO:0006449)2.79763692
69adhesion of symbiont to host (GO:0044406)2.79415177
70cell-cell junction maintenance (GO:0045217)2.78781721
71regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78291390
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.78204491
73long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.77026045
74dendritic spine morphogenesis (GO:0060997)2.76849229
75positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.76402488
76synaptic vesicle exocytosis (GO:0016079)2.75915125
77neuron cell-cell adhesion (GO:0007158)2.75508747
78long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.75240347
79peptidyl-arginine omega-N-methylation (GO:0035247)2.74738272
80proline transport (GO:0015824)2.74631389
81regulation of triglyceride catabolic process (GO:0010896)2.72963239
82activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.71868941
83regulation of synaptic vesicle exocytosis (GO:2000300)2.71351534
84cholesterol efflux (GO:0033344)2.70258076
85cellular protein complex localization (GO:0034629)2.69113757
86regulation of translational fidelity (GO:0006450)2.67284577
87branching involved in mammary gland duct morphogenesis (GO:0060444)2.66870818
88vitamin A metabolic process (GO:0006776)2.65566300
89regulation of glucose import in response to insulin stimulus (GO:2001273)2.64757560
90central nervous system myelination (GO:0022010)2.63837445
91axon ensheathment in central nervous system (GO:0032291)2.63837445
92glycolipid catabolic process (GO:0019377)2.63794144
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.63601074
94protein-lipid complex assembly (GO:0065005)2.63442676
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.61559141
96positive regulation of nuclease activity (GO:0032075)2.60444331
97fatty-acyl-CoA biosynthetic process (GO:0046949)2.59237816
98epithelial cell differentiation involved in prostate gland development (GO:0060742)2.59115469
99nuclear envelope reassembly (GO:0031468)2.58865377
100mitotic nuclear envelope reassembly (GO:0007084)2.58865377
101plasma lipoprotein particle assembly (GO:0034377)2.58763764
102gap junction assembly (GO:0016264)2.58595857
103neurotransmitter secretion (GO:0007269)2.58269382
104negative regulation of fatty acid transport (GO:2000192)2.57432057
105cell communication involved in cardiac conduction (GO:0086065)2.56196169
106stress fiber assembly (GO:0043149)2.55913526
107fatty-acyl-CoA metabolic process (GO:0035337)2.55782943
108protein complex localization (GO:0031503)2.54872672
109NADPH regeneration (GO:0006740)2.54612231
110gamma-aminobutyric acid transport (GO:0015812)2.53501768
111nucleobase-containing small molecule interconversion (GO:0015949)2.53093882
112regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52837643
113pyrimidine nucleobase catabolic process (GO:0006208)2.52440224
114multicellular organismal water homeostasis (GO:0050891)2.51799464
115positive regulation of keratinocyte differentiation (GO:0045618)2.50971673
116regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50665817
117mannose metabolic process (GO:0006013)2.49999967
118vesicle coating (GO:0006901)2.49483974
119cholesterol biosynthetic process (GO:0006695)2.48641079
120exploration behavior (GO:0035640)2.47835055
121dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47558619
122amyloid precursor protein catabolic process (GO:0042987)2.47517435
123positive regulation of epidermis development (GO:0045684)2.46934744
124positive regulation of epidermal cell differentiation (GO:0045606)2.46110047
125regulation of extracellular matrix disassembly (GO:0010715)2.45381357
126positive regulation of protein dephosphorylation (GO:0035307)2.45138692
127positive regulation of fatty acid biosynthetic process (GO:0045723)2.44273790
128neuron recognition (GO:0008038)2.44230886
129neuronal action potential propagation (GO:0019227)2.43636781
130bundle of His cell to Purkinje myocyte communication (GO:0086069)2.43332574
131positive regulation of receptor recycling (GO:0001921)2.42705191
132iron coordination entity transport (GO:1901678)2.42449838
133regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.41920453
134triglyceride biosynthetic process (GO:0019432)2.41737498
135regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.41614383
136positive regulation of triglyceride lipase activity (GO:0061365)2.41506011
137positive regulation of lipoprotein lipase activity (GO:0051006)2.41506011
138regulation of glucocorticoid metabolic process (GO:0031943)2.40520061
139dendrite morphogenesis (GO:0048813)2.40501099
140endocytic recycling (GO:0032456)2.40187275
141actin filament bundle organization (GO:0061572)2.39499065
142actin filament bundle assembly (GO:0051017)2.39499065
143positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.39474598
144cell adhesion mediated by integrin (GO:0033627)2.39312611
145cellular copper ion homeostasis (GO:0006878)2.39137290
146negative regulation of cholesterol transport (GO:0032375)2.37924428
147negative regulation of sterol transport (GO:0032372)2.37924428
148detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.37105424
149detection of temperature stimulus involved in sensory perception (GO:0050961)2.37105424
150regulation of cholesterol homeostasis (GO:2000188)2.36863538
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36755852
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36514139
153endoplasmic reticulum unfolded protein response (GO:0030968)2.35424022
154protein localization to synapse (GO:0035418)2.35375727
155peptidyl-proline hydroxylation (GO:0019511)2.34245459
156glycine transport (GO:0015816)2.33215608
157reverse cholesterol transport (GO:0043691)2.32704286
158regulation of cholesterol metabolic process (GO:0090181)2.32415672
159regulation of apoptotic process involved in morphogenesis (GO:1902337)2.31945089
160acylglycerol biosynthetic process (GO:0046463)2.31932820
161neutral lipid biosynthetic process (GO:0046460)2.31932820
162acyl-CoA biosynthetic process (GO:0071616)2.30866625
163thioester biosynthetic process (GO:0035384)2.30866625
164regulation of glutamate receptor signaling pathway (GO:1900449)2.30373465
165high-density lipoprotein particle remodeling (GO:0034375)2.30013311
166modulation by virus of host morphology or physiology (GO:0019048)2.29879584
167monosaccharide biosynthetic process (GO:0046364)2.29682288
168membrane protein ectodomain proteolysis (GO:0006509)2.29659327
169positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.29390100
170regulation of neuronal synaptic plasticity (GO:0048168)2.28509325
171regulation of synaptic vesicle transport (GO:1902803)2.27239892
172neurotransmitter transport (GO:0006836)2.26455713
173regulation of lipoprotein metabolic process (GO:0050746)2.26209951
174cell migration in hindbrain (GO:0021535)2.26166399
175mating behavior (GO:0007617)2.25073993
176axonal fasciculation (GO:0007413)2.24831824
177hormone catabolic process (GO:0042447)2.24465769
178lipoprotein transport (GO:0042953)2.24369364
179diacylglycerol metabolic process (GO:0046339)2.23866709
180CDP-diacylglycerol biosynthetic process (GO:0016024)2.23791989
181very-low-density lipoprotein particle assembly (GO:0034379)2.22707732
182purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.22500148
1833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.22500148
184activation of protein kinase A activity (GO:0034199)2.21819622
185cell communication by electrical coupling (GO:0010644)2.21336095
186CDP-diacylglycerol metabolic process (GO:0046341)2.21055453
187drinking behavior (GO:0042756)2.20227541
188long-chain fatty acid biosynthetic process (GO:0042759)2.20159481
189establishment of mitochondrion localization (GO:0051654)2.19730631
190alpha-linolenic acid metabolic process (GO:0036109)2.18761540
191lipoprotein metabolic process (GO:0042157)2.18333386
192sterol biosynthetic process (GO:0016126)2.17597454
193regulation of long-term neuronal synaptic plasticity (GO:0048169)2.16558499
194heme transport (GO:0015886)2.14676552
195modified amino acid transport (GO:0072337)2.14341716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84933922
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.59545063
3EZH2_22144423_ChIP-Seq_EOC_Human2.57552784
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.56670865
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37647523
6ELK3_25401928_ChIP-Seq_HUVEC_Human2.34734117
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24030850
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20202093
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.13793018
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12833815
11DROSHA_22980978_ChIP-Seq_HELA_Human2.12016970
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09925959
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09374486
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09374486
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07550888
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04497661
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02818451
18VDR_21846776_ChIP-Seq_THP-1_Human1.98739951
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98656395
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97769867
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93140871
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89251318
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88609156
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.85053588
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84734553
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83621838
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81759850
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81218606
29MYC_22102868_ChIP-Seq_BL_Human1.79800731
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77540146
31* TET1_21451524_ChIP-Seq_MESCs_Mouse1.75347846
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73835823
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70493046
34REST_21632747_ChIP-Seq_MESCs_Mouse1.70159111
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68405727
36KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67744288
37UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66946939
38RARB_27405468_Chip-Seq_BRAIN_Mouse1.65310490
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65306882
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.64756581
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63892593
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62711853
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58569932
44RXR_22158963_ChIP-Seq_LIVER_Mouse1.58542267
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.57141087
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.57009477
47CLOCK_20551151_ChIP-Seq_293T_Human1.56658819
48EED_16625203_ChIP-ChIP_MESCs_Mouse1.56212605
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.53986153
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.52375075
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.50661237
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49862181
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46167695
54P68_20966046_ChIP-Seq_HELA_Human1.45641038
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.45074655
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44908373
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44404695
58TCF7_22412390_ChIP-Seq_EML_Mouse1.44331867
59KDM2B_26808549_Chip-Seq_DND41_Human1.44140318
60ATF3_27146783_Chip-Seq_COLON_Human1.43898395
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42266489
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41690735
63* REST_18959480_ChIP-ChIP_MESCs_Mouse1.41378798
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39507772
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36737092
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35959552
67GBX2_23144817_ChIP-Seq_PC3_Human1.35926194
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35519329
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35311621
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34461138
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.34313952
72SMC4_20622854_ChIP-Seq_HELA_Human1.33416642
73AR_21572438_ChIP-Seq_LNCaP_Human1.32069944
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30777728
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29598987
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29420156
77KDM2B_26808549_Chip-Seq_K562_Human1.29133997
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26745635
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25090669
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24328396
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24162838
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23943933
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23782195
84LXR_22292898_ChIP-Seq_THP-1_Human1.21909490
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21287199
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21105783
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20604323
88CTCF_27219007_Chip-Seq_Bcells_Human1.20442054
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19451207
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19026387
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.18189413
92TP53_22127205_ChIP-Seq_IMR90_Human1.17477792
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.16256116
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.15933011
95SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14725884
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14699567
97* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14177359
98SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14089708
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13607863
100E2F7_22180533_ChIP-Seq_HELA_Human1.12778893
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12429303
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.12220289
103MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10035169
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09433599
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08789538
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08186139
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07913742
108SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06898496
109NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06393616
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06149610
111ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05340991
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05060160
113AHR_22903824_ChIP-Seq_MCF-7_Human1.04854189
114* UBF1/2_26484160_Chip-Seq_HMECs_Human1.04058780
115BCOR_27268052_Chip-Seq_Bcells_Human1.03634158
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03559155
117AR_21909140_ChIP-Seq_LNCAP_Human1.03145883
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02933534
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.99768130
120THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99361678
121KDM2B_26808549_Chip-Seq_JURKAT_Human0.99356030
122XRN2_22483619_ChIP-Seq_HELA_Human0.99246281
123ZNF263_19887448_ChIP-Seq_K562_Human0.98159931
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98148520
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97067469
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96854590
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.96265595
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.93922322
129* KLF5_25053715_ChIP-Seq_YYC3_Human0.93846792
130SOX2_20726797_ChIP-Seq_SW620_Human0.93846025
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.92804849
132VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92664945
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91725504
134CREB1_26743006_Chip-Seq_LNCaP_Human0.90433011
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89652372
136CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89645723
137RACK7_27058665_Chip-Seq_MCF-7_Human0.89289630
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89178868
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.88780095
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.88704387
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.88087549
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87633721
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.87608976
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87544614
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87478928
146RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86601485
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85989779
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.85811756
149CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85609338
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85299619
151RING1B_27294783_Chip-Seq_NPCs_Mouse0.84254539
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84067336
153GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84030169
154RXR_22108803_ChIP-Seq_LS180_Human0.82816779
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82756745
156P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82483847
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.80956804
158AR_19668381_ChIP-Seq_PC3_Human0.79445694
159PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.79216236
160EGR1_19032775_ChIP-ChIP_M12_Human0.79097081
161SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78645228
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.78034045
163TP63_22573176_ChIP-Seq_HFKS_Human0.76828542
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76422855
165RUNX1_27514584_Chip-Seq_MCF-7_Human0.76139436
166PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76063035
167CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75464054
168SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75379135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.36143336
2MP0004859_abnormal_synaptic_plasticity3.69150826
3MP0004270_analgesia3.45508985
4MP0001666_abnormal_nutrient_absorption3.16869453
5MP0005058_abnormal_lysosome_morphology3.11687995
6MP0002877_abnormal_melanocyte_morpholog2.98809977
7MP0002139_abnormal_hepatobiliary_system2.96218794
8MP0003566_abnormal_cell_adhesion2.79875279
9MP0005409_darkened_coat_color2.71027658
10MP0009840_abnormal_foam_cell2.69729096
11MP0003329_amyloid_beta_deposits2.68774095
12MP0003880_abnormal_central_pattern2.65296757
13MP0002822_catalepsy2.56524807
14MP0010234_abnormal_vibrissa_follicle2.55522306
15MP0001849_ear_inflammation2.49116621
16MP0005257_abnormal_intraocular_pressure2.44110713
17MP0003453_abnormal_keratinocyte_physiol2.39351560
18MP0003635_abnormal_synaptic_transmissio2.36807439
19MP0005085_abnormal_gallbladder_physiolo2.29682916
20MP0008875_abnormal_xenobiotic_pharmacok2.22065962
21MP0008260_abnormal_autophagy2.18465741
22MP0008438_abnormal_cutaneous_collagen2.07599651
23MP0004858_abnormal_nervous_system2.04182322
24MP0010329_abnormal_lipoprotein_level1.95600448
25MP0003183_abnormal_peptide_metabolism1.94786291
26MP0002064_seizures1.90087446
27MP0005076_abnormal_cell_differentiation1.87773086
28MP0004272_abnormal_basement_membrane1.85788097
29MP0010352_gastrointestinal_tract_polyps1.85538474
30MP0002063_abnormal_learning/memory/cond1.85311171
31MP0002734_abnormal_mechanical_nocicepti1.83870055
32MP0004233_abnormal_muscle_weight1.82012317
33MP0000678_abnormal_parathyroid_gland1.80775175
34MP0009745_abnormal_behavioral_response1.79098728
35* MP0002796_impaired_skin_barrier1.76401453
36MP0000604_amyloidosis1.74335297
37MP0009780_abnormal_chondrocyte_physiolo1.73479579
38MP0002060_abnormal_skin_morphology1.72576494
39MP0001440_abnormal_grooming_behavior1.66743513
40MP0000579_abnormal_nail_morphology1.66266797
41MP0002733_abnormal_thermal_nociception1.62201655
42MP0004885_abnormal_endolymph1.61592510
43MP0005623_abnormal_meninges_morphology1.60189812
44MP0004043_abnormal_pH_regulation1.59031909
45MP0002098_abnormal_vibrissa_morphology1.59005187
46MP0002272_abnormal_nervous_system1.57102348
47MP0001486_abnormal_startle_reflex1.56836264
48MP0005365_abnormal_bile_salt1.56778209
49MP0002572_abnormal_emotion/affect_behav1.56049733
50MP0003252_abnormal_bile_duct1.53516262
51MP0000920_abnormal_myelination1.52846180
52MP0009046_muscle_twitch1.51069383
53MP0001968_abnormal_touch/_nociception1.51051741
54* MP0001216_abnormal_epidermal_layer1.50338669
55MP0003705_abnormal_hypodermis_morpholog1.44837227
56MP0005423_abnormal_somatic_nervous1.40273283
57MP0005023_abnormal_wound_healing1.36366973
58MP0001970_abnormal_pain_threshold1.34901910
59MP0000003_abnormal_adipose_tissue1.34111167
60MP0010030_abnormal_orbit_morphology1.32987895
61MP0004019_abnormal_vitamin_homeostasis1.32708411
62MP0003690_abnormal_glial_cell1.32296810
63MP0001501_abnormal_sleep_pattern1.32161172
64MP0003091_abnormal_cell_migration1.32128106
65MP0009053_abnormal_anal_canal1.31914540
66MP0003191_abnormal_cellular_cholesterol1.29503818
67MP0003172_abnormal_lysosome_physiology1.28455953
68MP0002735_abnormal_chemical_nociception1.28352688
69MP0000778_abnormal_nervous_system1.26286573
70MP0000762_abnormal_tongue_morphology1.23852731
71MP0003283_abnormal_digestive_organ1.23844628
72MP0002118_abnormal_lipid_homeostasis1.21981341
73MP0004947_skin_inflammation1.19265218
74MP0001730_embryonic_growth_arrest1.18394286
75MP0001664_abnormal_digestion1.18226321
76* MP0010771_integument_phenotype1.16550115
77MP0002837_dystrophic_cardiac_calcinosis1.15407931
78MP0002736_abnormal_nociception_after1.11828950
79MP0001348_abnormal_lacrimal_gland1.11806620
80MP0005448_abnormal_energy_balance1.11609153
81MP0000955_abnormal_spinal_cord1.09649160
82MP0005666_abnormal_adipose_tissue1.09412474
83MP0000490_abnormal_crypts_of1.09396118
84MP0009379_abnormal_foot_pigmentation1.08508240
85MP0002909_abnormal_adrenal_gland1.08418126
86MP0002254_reproductive_system_inflammat1.07959643
87MP0004782_abnormal_surfactant_physiolog1.07646641
88MP0003879_abnormal_hair_cell1.06771737
89MP0005375_adipose_tissue_phenotype1.06197707
90MP0000858_altered_metastatic_potential1.05534890
91* MP0000462_abnormal_digestive_system1.04998022
92MP0000538_abnormal_urinary_bladder1.04678334
93MP0005332_abnormal_amino_acid1.04646717
94MP0003941_abnormal_skin_development1.03382861
95MP0005386_behavior/neurological_phenoty1.02222592
96MP0004924_abnormal_behavior1.02222592
97MP0002557_abnormal_social/conspecific_i1.01657912
98MP0008569_lethality_at_weaning1.01632617
99MP0002249_abnormal_larynx_morphology1.01401410
100MP0005167_abnormal_blood-brain_barrier1.01307908
101MP0000467_abnormal_esophagus_morphology1.01240017
102MP0006276_abnormal_autonomic_nervous1.00999806
103MP0002067_abnormal_sensory_capabilities1.00610734
104MP0004264_abnormal_extraembryonic_tissu1.00428148
105MP0000681_abnormal_thyroid_gland0.99859248
106MP0008961_abnormal_basal_metabolism0.99701466
107MP0004742_abnormal_vestibular_system0.99431352
108MP0000747_muscle_weakness0.96792462
109MP0003633_abnormal_nervous_system0.96240869
110* MP0002089_abnormal_postnatal_growth/wei0.95254306
111MP0003315_abnormal_perineum_morphology0.94934699
112* MP0009931_abnormal_skin_appearance0.93613478
113MP0003123_paternal_imprinting0.93204172
114* MP0000377_abnormal_hair_follicle0.93193284
115MP0009672_abnormal_birth_weight0.93178321
116MP0003634_abnormal_glial_cell0.92754965
117* MP0002066_abnormal_motor_capabilities/c0.91830293
118MP0010678_abnormal_skin_adnexa0.90598202
119MP0002896_abnormal_bone_mineralization0.88713709
120MP0002229_neurodegeneration0.88293885
121MP0004811_abnormal_neuron_physiology0.87622559
122MP0004957_abnormal_blastocyst_morpholog0.87483619
123MP0000751_myopathy0.87352385
124MP0005535_abnormal_body_temperature0.86317901
125MP0000733_abnormal_muscle_development0.85978907
126MP0000537_abnormal_urethra_morphology0.84411056
127MP0002882_abnormal_neuron_morphology0.84379347
128MP0002184_abnormal_innervation0.84067273
129MP0004185_abnormal_adipocyte_glucose0.83944330
130MP0004142_abnormal_muscle_tone0.81172387
131MP0003631_nervous_system_phenotype0.81140437
132MP0005451_abnormal_body_composition0.80637131
133MP0005621_abnormal_cell_physiology0.80588805
134MP0003075_altered_response_to0.79211676
135MP0000566_synostosis0.79165463
136MP0003693_abnormal_embryo_hatching0.78083740
137MP0000477_abnormal_intestine_morphology0.77396908
138MP0003111_abnormal_nucleus_morphology0.77065432
139MP0008872_abnormal_physiological_respon0.77065420
140MP0001243_abnormal_dermal_layer0.76469965
141MP0008874_decreased_physiological_sensi0.76452508
142MP0005584_abnormal_enzyme/coenzyme_acti0.75009839
143MP0005165_increased_susceptibility_to0.74934735
144* MP0002069_abnormal_eating/drinking_beha0.74738138
145MP0003632_abnormal_nervous_system0.74328109
146MP0005275_abnormal_skin_tensile0.73762662
147* MP0005501_abnormal_skin_physiology0.73361870
148MP0000627_abnormal_mammary_gland0.72885753
149MP0004381_abnormal_hair_follicle0.72074893
150MP0004510_myositis0.69782479
151MP0001177_atelectasis0.68654114
152MP0004147_increased_porphyrin_level0.68585758
153MP0010368_abnormal_lymphatic_system0.68519872
154* MP0002080_prenatal_lethality0.68450572
155MP0008932_abnormal_embryonic_tissue0.67314367
156MP0000534_abnormal_ureter_morphology0.66915386
157MP0003866_abnormal_defecation0.66487889
158MP0000350_abnormal_cell_proliferation0.65087363
159MP0005083_abnormal_biliary_tract0.64981503
160MP0001765_abnormal_ion_homeostasis0.64965264
161MP0005670_abnormal_white_adipose0.64418733
162MP0001915_intracranial_hemorrhage0.63795441
163MP0001529_abnormal_vocalization0.63476652
164MP0002090_abnormal_vision0.63326469
165MP0003868_abnormal_feces_composition0.63163986
166MP0002086_abnormal_extraembryonic_tissu0.61964733
167MP0005166_decreased_susceptibility_to0.61309342
168MP0001661_extended_life_span0.61061365
169MP0009333_abnormal_splenocyte_physiolog0.60693823

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.29594279
2Neurofibrillary tangles (HP:0002185)4.06137384
3Cerebral inclusion bodies (HP:0100314)3.81973080
4Supranuclear gaze palsy (HP:0000605)3.80022200
5Ileus (HP:0002595)3.71702857
6Hypobetalipoproteinemia (HP:0003563)3.50354518
7Hyperacusis (HP:0010780)3.39138501
8Premature rupture of membranes (HP:0001788)3.35305111
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.26416584
10Focal seizures (HP:0007359)3.16106417
11Abnormality of the corticospinal tract (HP:0002492)3.15308354
12Focal motor seizures (HP:0011153)3.15276002
13Insidious onset (HP:0003587)3.05729581
14Termporal pattern (HP:0011008)3.05729581
15Vertebral compression fractures (HP:0002953)3.05303506
16Ankle clonus (HP:0011448)3.03822214
17Xanthomatosis (HP:0000991)2.95431109
18Acanthocytosis (HP:0001927)2.93911193
19Distal lower limb amyotrophy (HP:0008944)2.88383375
20Malnutrition (HP:0004395)2.78685596
21Ulnar bowing (HP:0003031)2.68103362
22Protrusio acetabuli (HP:0003179)2.67912240
23Visual hallucinations (HP:0002367)2.66263594
24Intention tremor (HP:0002080)2.65422490
25Abnormality of nail color (HP:0100643)2.63595746
26Distal lower limb muscle weakness (HP:0009053)2.59504648
27Action tremor (HP:0002345)2.59044997
28Broad face (HP:0000283)2.55059584
29Short nail (HP:0001799)2.54245215
30Right ventricular cardiomyopathy (HP:0011663)2.53319081
31Flat acetabular roof (HP:0003180)2.51378058
32Pili torti (HP:0003777)2.51029117
33Atonic seizures (HP:0010819)2.50884072
34Abnormality of the distal phalanges of the toes (HP:0010182)2.46422037
35Abnormal eating behavior (HP:0100738)2.45561351
36Insomnia (HP:0100785)2.45384403
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.44139144
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.44139144
39Cerebral aneurysm (HP:0004944)2.43687776
40Fragile skin (HP:0001030)2.42737569
41Thin bony cortex (HP:0002753)2.39384110
42Pheochromocytoma (HP:0002666)2.35632912
43Spastic gait (HP:0002064)2.35444150
44Increased connective tissue (HP:0009025)2.34010222
45Atrophic scars (HP:0001075)2.33999184
46Hydroxyprolinuria (HP:0003080)2.32035782
47Abnormality of proline metabolism (HP:0010907)2.32035782
48Axonal loss (HP:0003447)2.31584436
49Akinesia (HP:0002304)2.30636377
50Hypolipoproteinemia (HP:0010981)2.28284906
51Mutism (HP:0002300)2.27090743
52Polyphagia (HP:0002591)2.22270563
53Dysmetria (HP:0001310)2.20663216
54Osteolytic defects of the hand bones (HP:0009699)2.20187771
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.20187771
56Trismus (HP:0000211)2.19451185
57Absence seizures (HP:0002121)2.18609325
58Ventricular fibrillation (HP:0001663)2.16442738
59Spinal cord compression (HP:0002176)2.16371269
60Lower limb amyotrophy (HP:0007210)2.15413031
61Abnormal gallbladder physiology (HP:0012438)2.15200691
62Cholecystitis (HP:0001082)2.15200691
63Intrahepatic cholestasis (HP:0001406)2.14970668
64Difficulty climbing stairs (HP:0003551)2.14790040
65Abnormal social behavior (HP:0012433)2.13439831
66Impaired social interactions (HP:0000735)2.13439831
67Increased IgE level (HP:0003212)2.13367939
68Torticollis (HP:0000473)2.13061518
69Epidermoid cyst (HP:0200040)2.12658739
70Generalized tonic-clonic seizures (HP:0002069)2.11594671
71Abnormality of the Achilles tendon (HP:0005109)2.11286387
72Hand muscle atrophy (HP:0009130)2.10552038
73Amyloidosis (HP:0011034)2.10495778
74Cervical subluxation (HP:0003308)2.09201512
75Achilles tendon contracture (HP:0001771)2.07307066
76Urinary urgency (HP:0000012)2.07280043
77Morphological abnormality of the pyramidal tract (HP:0002062)2.06505039
78Cerebral hemorrhage (HP:0001342)2.05350669
79Alopecia of scalp (HP:0002293)2.05234686
80Back pain (HP:0003418)2.03754038
81Spastic tetraparesis (HP:0001285)2.03724763
82Potter facies (HP:0002009)2.03531640
83Facial shape deformation (HP:0011334)2.03531640
84Centrally nucleated skeletal muscle fibers (HP:0003687)2.03033360
85J-shaped sella turcica (HP:0002680)2.01614325
86Dialeptic seizures (HP:0011146)2.01393306
87Spinal rigidity (HP:0003306)1.99286807
88Epileptic encephalopathy (HP:0200134)1.99070119
89Abnormality of the lower motor neuron (HP:0002366)1.98719265
90Stridor (HP:0010307)1.96702099
91Nail dystrophy (HP:0008404)1.96562945
92Turricephaly (HP:0000262)1.95199268
93Abnormal hair laboratory examination (HP:0003328)1.94853321
94Fat malabsorption (HP:0002630)1.94399508
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.94104138
96Advanced eruption of teeth (HP:0006288)1.93254615
97Deep venous thrombosis (HP:0002625)1.93153888
98Abnormality of carpal bone ossification (HP:0006257)1.92789856
99Postural instability (HP:0002172)1.91637539
100Onycholysis (HP:0001806)1.91523439
101Mildly elevated creatine phosphokinase (HP:0008180)1.91514306
102Abdominal distention (HP:0003270)1.91389556
103Scanning speech (HP:0002168)1.89929283
104Selective tooth agenesis (HP:0001592)1.89786127
105Abnormal ossification of hand bones (HP:0005921)1.89420568
106Abnormality of glycolipid metabolism (HP:0010969)1.89409252
107Abnormality of liposaccharide metabolism (HP:0010968)1.89409252
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.89409252
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88311291
110Hypokinesia (HP:0002375)1.88087223
111Natal tooth (HP:0000695)1.86729227
112Focal dystonia (HP:0004373)1.86379437
113Lower limb muscle weakness (HP:0007340)1.86350183
114Craniofacial dystonia (HP:0012179)1.86320138
115Progressive cerebellar ataxia (HP:0002073)1.85866328
116Abnormality of the umbilical cord (HP:0010881)1.85715532
117Urinary bladder sphincter dysfunction (HP:0002839)1.85580767
118Generalized amyotrophy (HP:0003700)1.85237990
119Shallow orbits (HP:0000586)1.84551240
120Hemorrhage of the eye (HP:0011885)1.84237277
121Neuroendocrine neoplasm (HP:0100634)1.83764266
122Conjugated hyperbilirubinemia (HP:0002908)1.83709891
123Rapidly progressive (HP:0003678)1.83628575
124Dysdiadochokinesis (HP:0002075)1.83198230
125Neuronal loss in central nervous system (HP:0002529)1.82559043
126Onion bulb formation (HP:0003383)1.80626343
127Ankyloglossia (HP:0010296)1.80355753
128Thick nail (HP:0001805)1.78700286
129Widely patent fontanelles and sutures (HP:0004492)1.78640605
130Abnormality of glycine metabolism (HP:0010895)1.78567293
131Abnormality of serine family amino acid metabolism (HP:0010894)1.78567293
132Syncope (HP:0001279)1.78183775
133Hyperglycinuria (HP:0003108)1.77280494
134Elbow flexion contracture (HP:0002987)1.76557892
135Disproportionate tall stature (HP:0001519)1.76081168
136Bone pain (HP:0002653)1.75600020
137Psychosis (HP:0000709)1.75029233
138Plantar hyperkeratosis (HP:0007556)1.74230603
139Multiple lipomas (HP:0001012)1.73962891
140Upper limb amyotrophy (HP:0009129)1.73800755
141Distal upper limb amyotrophy (HP:0007149)1.73800755
142Clonus (HP:0002169)1.73248686
143Ankle contracture (HP:0006466)1.72681316
144Long palpebral fissure (HP:0000637)1.71649602
145Nephrolithiasis (HP:0000787)1.71605162
146Megalencephaly (HP:0001355)1.70208635
147Fragile nails (HP:0001808)1.69393418
148Depression (HP:0000716)1.68996700
149Hammertoe (HP:0001765)1.68847536
150Generalized myoclonic seizures (HP:0002123)1.67875426
151Hyporeflexia of lower limbs (HP:0002600)1.67692740
152Ketoacidosis (HP:0001993)1.67206796
153Hamartoma of the eye (HP:0010568)1.66665903
154Wormian bones (HP:0002645)1.66618720
155Milia (HP:0001056)1.65731124
156Asymmetry of the thorax (HP:0001555)1.65516444
157Congenital glaucoma (HP:0001087)1.65162967
158Skin nodule (HP:0200036)1.64580906
159Bronchomalacia (HP:0002780)1.63784668
160Hyperparathyroidism (HP:0000843)1.63473156
161Status epilepticus (HP:0002133)1.62999162
162Mitral regurgitation (HP:0001653)1.62931342
163Abnormality of oral frenula (HP:0000190)1.62719067
164Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.62249274
165Blue sclerae (HP:0000592)1.61862603
166Distal sensory impairment (HP:0002936)1.61791387
167Cupped ribs (HP:0000887)1.61767663
168Abnormality of monocarboxylic acid metabolism (HP:0010996)1.61751641
169Dysostosis multiplex (HP:0000943)1.61166771
170Growth hormone excess (HP:0000845)1.60902918
171Gastrointestinal dysmotility (HP:0002579)1.60784323
172Myopathic facies (HP:0002058)1.60219745
173Increased cerebral lipofuscin (HP:0011813)1.59450648
174Hypercalcemia (HP:0003072)1.59278992
175Ridged nail (HP:0001807)1.58422523
176Neonatal death (HP:0003811)1.58163246
177Acanthosis nigricans (HP:0000956)1.58103454
178Overriding aorta (HP:0002623)1.57079757
179Bladder diverticulum (HP:0000015)1.56595135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.42962304
2MAP3K93.37306370
3EPHA23.24554450
4IRAK33.17461880
5MARK12.94819063
6NME22.80618878
7PRPF4B2.61514328
8EEF2K2.46499733
9NTRK12.32729129
10TESK12.32026029
11EPHA42.27738928
12NTRK32.18511750
13KSR22.17971436
14PAK61.99781285
15EPHB11.97402545
16LMTK21.96080741
17MAP3K21.95771184
18TESK21.92455331
19MINK11.88892357
20STK391.86865559
21PAK41.84269267
22TYRO31.76778813
23MAP3K41.72032366
24DAPK21.64738872
25TTN1.60764351
26MST1R1.56704473
27MAP2K41.54352919
28OXSR11.54349251
29CDK121.53869293
30RIPK11.53193078
31PKN21.47592916
32TAOK11.47080282
33FRK1.45312405
34SCYL21.44595912
35TAOK21.41646504
36GRK61.41097813
37NTRK21.30156144
38ERN11.29044457
39PAK31.28112310
40CDK51.27546472
41TRIB31.27223157
42WNK41.26965672
43NME11.24407321
44PIM21.22853892
45PHKG11.22795596
46PHKG21.22795596
47FGFR41.15952144
48RIPK41.15532732
49ICK1.15222977
50MST41.14973879
51UHMK11.12831835
52MAP3K111.11773442
53LATS21.10095979
54CAMKK11.10001052
55IRAK21.06346509
56FGR1.05992087
57DDR21.05527604
58GRK51.05167626
59LIMK11.04831878
60EPHB21.02899260
61PRKG21.02842879
62FER1.02290963
63PDPK11.00782530
64RET1.00450548
65PTK20.99733204
66MAP3K100.98765967
67MAP3K30.98097161
68KSR10.96945135
69MTOR0.96807009
70BRAF0.95772754
71ARAF0.95586055
72MET0.95189876
73MAP3K120.94292129
74MAPKAPK30.91397849
75PRKD30.90901949
76ILK0.89609937
77PRKD20.89553667
78PKN10.88192345
79MAP3K80.87732340
80FGFR20.85832578
81MAP2K20.85832109
82STK110.85608566
83MAP2K30.84065116
84PTK60.82368158
85CAMK1G0.82140155
86MARK20.80190579
87WNK10.79213939
88RPS6KA20.78607669
89CAMK2B0.78364671
90MAP2K70.77954095
91CDK140.77783501
92FES0.76988543
93BUB10.76227329
94CDK150.74956973
95ROCK20.74935270
96CAMK2A0.73580070
97MAP3K10.72445226
98BCR0.72419465
99CSNK1G20.72159977
100BMX0.71838106
101RPS6KB20.71801668
102PBK0.71780863
103ABL20.70078718
104MAP2K10.69906662
105CDK180.69871021
106CDK190.69276535
107PRKCI0.68534081
108SIK20.68234480
109TNIK0.68088211
110PRKCZ0.66504434
111MAP3K70.66179426
112CAMK2G0.65819422
113CDK11A0.65269972
114PNCK0.65140222
115FYN0.64643709
116PDK10.63875606
117MAPK130.63789290
118PDGFRA0.61854399
119CDK70.61520925
120MAP2K60.61356601
121MAPK110.61305123
122CAMK2D0.61134693
123DAPK10.59682779
124SGK2230.58897305
125SGK4940.58897305
126PRKCH0.57840759
127PRKCG0.57706769
128PAK20.57312220
129DMPK0.56000174
130STK380.55960486
131ALK0.55316095
132MATK0.54083875
133ERBB20.54067599
134AKT20.53957571
135AURKA0.51669956
136SIK10.49782213
137BRSK10.49330460
138MAP3K130.48390986
139CSNK1G30.48285777
140MAPKAPK50.46460102
141CDC42BPA0.46042925
142DAPK30.45350852
143CAMK1D0.44750289
144LRRK20.43747510
145KDR0.43620799
146ERBB40.41436842
147MAP3K60.37866873
148MOS0.37473301
149PAK10.34196884
150VRK20.33724741
151RAF10.33020710
152RPS6KC10.29881360
153RPS6KL10.29881360
154CLK10.27022936

Predicted pathways (KEGG)

RankGene SetZ-score
1* Fat digestion and absorption_Homo sapiens_hsa049752.63163122
2Other glycan degradation_Homo sapiens_hsa005112.33920003
3Sulfur relay system_Homo sapiens_hsa041222.23725574
4Nitrogen metabolism_Homo sapiens_hsa009102.16526522
5Pentose phosphate pathway_Homo sapiens_hsa000301.93832659
6Mineral absorption_Homo sapiens_hsa049781.93351084
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89635139
8Biosynthesis of amino acids_Homo sapiens_hsa012301.85855961
9Vitamin B6 metabolism_Homo sapiens_hsa007501.84872629
10Bile secretion_Homo sapiens_hsa049761.83768637
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.78696298
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72651904
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69995475
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69520404
15Prion diseases_Homo sapiens_hsa050201.68040954
16Synaptic vesicle cycle_Homo sapiens_hsa047211.65804567
17Bladder cancer_Homo sapiens_hsa052191.63099955
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.62438100
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.59310164
20Vitamin digestion and absorption_Homo sapiens_hsa049771.58951927
21Sulfur metabolism_Homo sapiens_hsa009201.57445649
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.52334073
23Steroid biosynthesis_Homo sapiens_hsa001001.51905445
24Renin-angiotensin system_Homo sapiens_hsa046141.50804138
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49997789
26Butanoate metabolism_Homo sapiens_hsa006501.49250063
27Arginine biosynthesis_Homo sapiens_hsa002201.48790997
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45496032
29Chronic myeloid leukemia_Homo sapiens_hsa052201.43475415
30Caffeine metabolism_Homo sapiens_hsa002321.35060027
31Salivary secretion_Homo sapiens_hsa049701.27967071
32Thyroid cancer_Homo sapiens_hsa052161.27595940
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27450961
34Fatty acid elongation_Homo sapiens_hsa000621.25245641
35GABAergic synapse_Homo sapiens_hsa047271.24285803
36Nicotine addiction_Homo sapiens_hsa050331.23816581
37Carbon metabolism_Homo sapiens_hsa012001.23558130
38Gastric acid secretion_Homo sapiens_hsa049711.21611620
39Starch and sucrose metabolism_Homo sapiens_hsa005001.18278949
40Histidine metabolism_Homo sapiens_hsa003401.17813514
41Glutamatergic synapse_Homo sapiens_hsa047241.14018045
42Glioma_Homo sapiens_hsa052141.12717182
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12706899
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11884629
45N-Glycan biosynthesis_Homo sapiens_hsa005101.10083502
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09119263
47Acute myeloid leukemia_Homo sapiens_hsa052211.08045520
48Phenylalanine metabolism_Homo sapiens_hsa003601.07793747
49Non-small cell lung cancer_Homo sapiens_hsa052231.06876784
50Insulin signaling pathway_Homo sapiens_hsa049101.06702549
51Long-term potentiation_Homo sapiens_hsa047201.05863683
52Circadian entrainment_Homo sapiens_hsa047131.05722923
53Endometrial cancer_Homo sapiens_hsa052131.05505696
54Lysosome_Homo sapiens_hsa041421.03005720
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02949976
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01404705
57* PPAR signaling pathway_Homo sapiens_hsa033201.00856847
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99951603
59Dopaminergic synapse_Homo sapiens_hsa047280.99574641
60Insulin secretion_Homo sapiens_hsa049110.99570951
61Fatty acid metabolism_Homo sapiens_hsa012120.98896892
62Glycerolipid metabolism_Homo sapiens_hsa005610.97733957
63Galactose metabolism_Homo sapiens_hsa000520.97359012
64Long-term depression_Homo sapiens_hsa047300.96997294
65Protein digestion and absorption_Homo sapiens_hsa049740.96601212
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95622545
67Pancreatic cancer_Homo sapiens_hsa052120.94345830
68Notch signaling pathway_Homo sapiens_hsa043300.93731335
69Focal adhesion_Homo sapiens_hsa045100.93633763
70Small cell lung cancer_Homo sapiens_hsa052220.93144511
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93078836
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93020947
73Renin secretion_Homo sapiens_hsa049240.92880274
74Tryptophan metabolism_Homo sapiens_hsa003800.92553696
75Cholinergic synapse_Homo sapiens_hsa047250.92550943
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91963797
77Proteoglycans in cancer_Homo sapiens_hsa052050.91847726
78Axon guidance_Homo sapiens_hsa043600.91478385
79AMPK signaling pathway_Homo sapiens_hsa041520.90916265
80GnRH signaling pathway_Homo sapiens_hsa049120.89372854
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.89328979
82Fatty acid degradation_Homo sapiens_hsa000710.87862190
83Type II diabetes mellitus_Homo sapiens_hsa049300.85923794
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85724533
85Fatty acid biosynthesis_Homo sapiens_hsa000610.84730905
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84436259
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83842975
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83647802
89Amphetamine addiction_Homo sapiens_hsa050310.83271393
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.82052389
91Cocaine addiction_Homo sapiens_hsa050300.81037579
92Olfactory transduction_Homo sapiens_hsa047400.80857810
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80540260
94Morphine addiction_Homo sapiens_hsa050320.79746529
95Gap junction_Homo sapiens_hsa045400.79236433
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78788150
97ECM-receptor interaction_Homo sapiens_hsa045120.78635275
98Collecting duct acid secretion_Homo sapiens_hsa049660.78616874
99Pyruvate metabolism_Homo sapiens_hsa006200.74663404
100Endocytosis_Homo sapiens_hsa041440.74643974
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.74455498
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.73555959
103Amoebiasis_Homo sapiens_hsa051460.72421119
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70927432
105Renal cell carcinoma_Homo sapiens_hsa052110.70756282
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69893091
107Sphingolipid metabolism_Homo sapiens_hsa006000.69792658
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69580895
109Serotonergic synapse_Homo sapiens_hsa047260.69469729
110Thyroid hormone synthesis_Homo sapiens_hsa049180.68463566
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67804280
112Pancreatic secretion_Homo sapiens_hsa049720.66648686
113Inositol phosphate metabolism_Homo sapiens_hsa005620.65216333
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65168178
115Fructose and mannose metabolism_Homo sapiens_hsa000510.65155282
116Shigellosis_Homo sapiens_hsa051310.64871283
117Estrogen signaling pathway_Homo sapiens_hsa049150.64341764
118Ether lipid metabolism_Homo sapiens_hsa005650.64333506
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.63860185
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63577561
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63039324
122mTOR signaling pathway_Homo sapiens_hsa041500.61422065
123Oxytocin signaling pathway_Homo sapiens_hsa049210.61029538
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60354371
125Glucagon signaling pathway_Homo sapiens_hsa049220.59970858
126Vibrio cholerae infection_Homo sapiens_hsa051100.59884604
127Apoptosis_Homo sapiens_hsa042100.59290937
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.59150774
129ABC transporters_Homo sapiens_hsa020100.59050454
130Taste transduction_Homo sapiens_hsa047420.55844181
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55779337
132Cardiac muscle contraction_Homo sapiens_hsa042600.55761779
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.55655174
134Hepatitis C_Homo sapiens_hsa051600.55318491
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54983946
136Adherens junction_Homo sapiens_hsa045200.54174335
137Salmonella infection_Homo sapiens_hsa051320.52900369
138AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52698935
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52430670
140Phospholipase D signaling pathway_Homo sapiens_hsa040720.51503095
141beta-Alanine metabolism_Homo sapiens_hsa004100.50775389
142Folate biosynthesis_Homo sapiens_hsa007900.50764252
143Dorso-ventral axis formation_Homo sapiens_hsa043200.50413201
144VEGF signaling pathway_Homo sapiens_hsa043700.50117069
145Arginine and proline metabolism_Homo sapiens_hsa003300.49740984
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.49609665
147Tight junction_Homo sapiens_hsa045300.49295837
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49144083
149Propanoate metabolism_Homo sapiens_hsa006400.49032600
150Melanogenesis_Homo sapiens_hsa049160.48959326
151ErbB signaling pathway_Homo sapiens_hsa040120.48844684
152Alzheimers disease_Homo sapiens_hsa050100.48577479
153Tyrosine metabolism_Homo sapiens_hsa003500.48565557
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48267337
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.48135613
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48020870
157Leukocyte transendothelial migration_Homo sapiens_hsa046700.46930645
158Choline metabolism in cancer_Homo sapiens_hsa052310.46109285
159Peroxisome_Homo sapiens_hsa041460.45956867
160MicroRNAs in cancer_Homo sapiens_hsa052060.44533878

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