SLC27A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.36492373
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64408142
3L-phenylalanine catabolic process (GO:0006559)7.64408142
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31352515
5L-phenylalanine metabolic process (GO:0006558)7.31352515
6omega-hydroxylase P450 pathway (GO:0097267)7.05206830
7epoxygenase P450 pathway (GO:0019373)6.91198385
8aromatic amino acid family catabolic process (GO:0009074)6.89973602
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35663905
10oxidative demethylation (GO:0070989)6.29161062
11indole-containing compound catabolic process (GO:0042436)6.24254564
12indolalkylamine catabolic process (GO:0046218)6.24254564
13tryptophan catabolic process (GO:0006569)6.24254564
14kynurenine metabolic process (GO:0070189)6.10541707
15tryptophan metabolic process (GO:0006568)5.87316682
16* bile acid biosynthetic process (GO:0006699)5.80469138
17glyoxylate metabolic process (GO:0046487)5.79658966
18urea cycle (GO:0000050)5.75160538
19urea metabolic process (GO:0019627)5.75160538
20negative regulation of fibrinolysis (GO:0051918)5.65124030
21alpha-linolenic acid metabolic process (GO:0036109)5.62287750
22high-density lipoprotein particle remodeling (GO:0034375)5.60030226
23regulation of fibrinolysis (GO:0051917)5.44711076
24protein carboxylation (GO:0018214)5.42341062
25peptidyl-glutamic acid carboxylation (GO:0017187)5.42341062
26sulfur amino acid catabolic process (GO:0000098)5.42304066
27complement activation, alternative pathway (GO:0006957)5.40651730
28cysteine metabolic process (GO:0006534)5.38924088
29regulation of protein activation cascade (GO:2000257)5.37309792
30drug metabolic process (GO:0017144)5.31457795
31nitrogen cycle metabolic process (GO:0071941)5.28832049
32serine family amino acid catabolic process (GO:0009071)5.19986891
33aromatic amino acid family metabolic process (GO:0009072)5.01861511
34regulation of complement activation (GO:0030449)5.01775337
35* bile acid metabolic process (GO:0008206)5.00884978
36regulation of cholesterol esterification (GO:0010872)4.88870088
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87418808
38reverse cholesterol transport (GO:0043691)4.86588559
39tyrosine metabolic process (GO:0006570)4.85598161
40homocysteine metabolic process (GO:0050667)4.84885306
41regulation of triglyceride catabolic process (GO:0010896)4.84705546
42S-adenosylmethionine metabolic process (GO:0046500)4.84410251
43protein-lipid complex remodeling (GO:0034368)4.79040654
44macromolecular complex remodeling (GO:0034367)4.79040654
45plasma lipoprotein particle remodeling (GO:0034369)4.79040654
46alpha-amino acid catabolic process (GO:1901606)4.69924056
47triglyceride homeostasis (GO:0070328)4.65569532
48acylglycerol homeostasis (GO:0055090)4.65569532
49amino-acid betaine metabolic process (GO:0006577)4.61692224
50lysine metabolic process (GO:0006553)4.60158214
51lysine catabolic process (GO:0006554)4.60158214
52negative regulation of cholesterol transport (GO:0032375)4.59402117
53negative regulation of sterol transport (GO:0032372)4.59402117
54phospholipid efflux (GO:0033700)4.57074176
55phenylpropanoid metabolic process (GO:0009698)4.54816560
56glycine metabolic process (GO:0006544)4.49650112
57coenzyme catabolic process (GO:0009109)4.44158876
58alkaloid metabolic process (GO:0009820)4.42594584
59indolalkylamine metabolic process (GO:0006586)4.42111269
60imidazole-containing compound metabolic process (GO:0052803)4.41942083
61plasma lipoprotein particle clearance (GO:0034381)4.40171816
62amine catabolic process (GO:0009310)4.34187434
63cellular biogenic amine catabolic process (GO:0042402)4.34187434
64cellular glucuronidation (GO:0052695)4.32016988
65cellular amino acid catabolic process (GO:0009063)4.31818245
66glutamate metabolic process (GO:0006536)4.27331680
67cholesterol efflux (GO:0033344)4.25006924
68serine family amino acid metabolic process (GO:0009069)4.22987715
69* bile acid and bile salt transport (GO:0015721)4.15819534
70benzene-containing compound metabolic process (GO:0042537)4.15615611
71ethanol oxidation (GO:0006069)4.14443053
72ethanol metabolic process (GO:0006067)4.12727274
73cellular modified amino acid catabolic process (GO:0042219)4.08028975
74arginine metabolic process (GO:0006525)4.07043479
75low-density lipoprotein particle remodeling (GO:0034374)4.06600456
76dicarboxylic acid biosynthetic process (GO:0043650)4.05331808
77serine family amino acid biosynthetic process (GO:0009070)4.04322060
78fibrinolysis (GO:0042730)4.03083671
79plasma lipoprotein particle assembly (GO:0034377)4.02468011
80aldehyde catabolic process (GO:0046185)4.01655625
81drug catabolic process (GO:0042737)3.93792703
82blood coagulation, intrinsic pathway (GO:0007597)3.87337984
83flavonoid metabolic process (GO:0009812)3.86003899
84amino acid salvage (GO:0043102)3.84840510
85L-methionine salvage (GO:0071267)3.84840510
86L-methionine biosynthetic process (GO:0071265)3.84840510
87cofactor catabolic process (GO:0051187)3.83865440
88glucuronate metabolic process (GO:0019585)3.83051678
89uronic acid metabolic process (GO:0006063)3.83051678
90very-low-density lipoprotein particle assembly (GO:0034379)3.80830476
91complement activation, classical pathway (GO:0006958)3.79854726
92behavioral response to nicotine (GO:0035095)3.79363504
93positive regulation of triglyceride lipase activity (GO:0061365)3.78348859
94positive regulation of lipoprotein lipase activity (GO:0051006)3.78348859
95carboxylic acid catabolic process (GO:0046395)3.76930210
96organic acid catabolic process (GO:0016054)3.76930210
97regulation of bile acid biosynthetic process (GO:0070857)3.76725034
98cholesterol homeostasis (GO:0042632)3.76596489
99complement activation (GO:0006956)3.76575931
100negative regulation of lipase activity (GO:0060192)3.76067428
101positive regulation of lipid catabolic process (GO:0050996)3.75314081
102protein activation cascade (GO:0072376)3.74552228
103phospholipid homeostasis (GO:0055091)3.74535700
104cytolysis (GO:0019835)3.72448715
105acetyl-CoA metabolic process (GO:0006084)3.71655715
106sterol homeostasis (GO:0055092)3.70262592
107short-chain fatty acid metabolic process (GO:0046459)3.67230111
108regulation of cholesterol homeostasis (GO:2000188)3.66934314
109plasma lipoprotein particle organization (GO:0071827)3.63853609
110* cellular ketone body metabolic process (GO:0046950)3.62029181
111protein-lipid complex assembly (GO:0065005)3.60730468
112NAD biosynthetic process (GO:0009435)3.60589241
113pyridine nucleotide biosynthetic process (GO:0019363)3.56966372
114nicotinamide nucleotide biosynthetic process (GO:0019359)3.56966372
115arginine catabolic process (GO:0006527)3.50796039
116opsonization (GO:0008228)3.49544927
117heme transport (GO:0015886)3.43777240
118pyrimidine nucleobase catabolic process (GO:0006208)3.39851600
119water-soluble vitamin biosynthetic process (GO:0042364)3.34804494
120indole-containing compound metabolic process (GO:0042430)3.23360768
121regulation of plasminogen activation (GO:0010755)3.19334072
122* ketone body metabolic process (GO:1902224)3.17064197
123negative regulation of protein activation cascade (GO:2000258)3.14874204
124xenobiotic metabolic process (GO:0006805)3.11542876
125nucleobase catabolic process (GO:0046113)3.09965816
126methionine biosynthetic process (GO:0009086)3.06514496
127methionine metabolic process (GO:0006555)3.04712608
128response to misfolded protein (GO:0051788)3.03925737
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.98267995
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.98267995
131intestinal cholesterol absorption (GO:0030299)2.97235628
132peptidyl-glutamic acid modification (GO:0018200)2.96747730
133xenobiotic catabolic process (GO:0042178)2.92422663
134regulation of humoral immune response (GO:0002920)2.89584072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.43908234
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.20281240
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.06294247
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.52961338
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.34159328
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.15332392
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81303744
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06320692
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04432482
10ZNF274_21170338_ChIP-Seq_K562_Hela3.31744750
11VDR_22108803_ChIP-Seq_LS180_Human3.08681049
12GBX2_23144817_ChIP-Seq_PC3_Human2.64830363
13IGF1R_20145208_ChIP-Seq_DFB_Human2.42095731
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40184543
15EZH2_22144423_ChIP-Seq_EOC_Human2.11903617
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08599275
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06749152
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06609838
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9891087
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98923836
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96211722
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96124730
23ER_23166858_ChIP-Seq_MCF-7_Human1.93279270
24IRF1_19129219_ChIP-ChIP_H3396_Human1.93041542
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92462335
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64525066
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63082206
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.61723415
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.59466594
30HTT_18923047_ChIP-ChIP_STHdh_Human1.57912085
31P300_19829295_ChIP-Seq_ESCs_Human1.54984698
32EWS_26573619_Chip-Seq_HEK293_Human1.54027757
33CLOCK_20551151_ChIP-Seq_293T_Human1.52972842
34STAT3_23295773_ChIP-Seq_U87_Human1.47144803
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.46752108
36FUS_26573619_Chip-Seq_HEK293_Human1.46090418
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43146920
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39913969
39* HNF4A_19822575_ChIP-Seq_HepG2_Human1.39755473
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39733064
41CBP_20019798_ChIP-Seq_JUKART_Human1.39733064
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38110354
43GATA1_22025678_ChIP-Seq_K562_Human1.37673302
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36879813
45TP53_22573176_ChIP-Seq_HFKS_Human1.34891469
46REST_21632747_ChIP-Seq_MESCs_Mouse1.34890430
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33269634
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.33269634
49TCF4_23295773_ChIP-Seq_U87_Human1.32738991
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32357513
51NANOG_19829295_ChIP-Seq_ESCs_Human1.32097112
52SOX2_19829295_ChIP-Seq_ESCs_Human1.32097112
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.29686552
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28296820
55TCF4_22108803_ChIP-Seq_LS180_Human1.27933341
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27055942
57AR_25329375_ChIP-Seq_VCAP_Human1.24685671
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24176567
59RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22639427
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21645718
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21539630
62ERA_21632823_ChIP-Seq_H3396_Human1.21224842
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.20964009
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20453368
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20138566
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19948601
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19126786
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17087629
69MYC_19829295_ChIP-Seq_ESCs_Human1.17031758
70SMAD4_21799915_ChIP-Seq_A2780_Human1.15265010
71RUNX2_22187159_ChIP-Seq_PCA_Human1.13329105
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13174391
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13174391
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12969029
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12269280
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.12260990
77MYC_18940864_ChIP-ChIP_HL60_Human1.09928650
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.09156872
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08240267
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07030850
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06845065
82DROSHA_22980978_ChIP-Seq_HELA_Human1.05242158
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04560776
84FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04281640
85AR_21572438_ChIP-Seq_LNCaP_Human1.03163370
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.03044842
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00248990
88NANOG_20526341_ChIP-Seq_ESCs_Human1.00125352
89OCT4_20526341_ChIP-Seq_ESCs_Human1.00086274
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99411543
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99127047
92HOXB7_26014856_ChIP-Seq_BT474_Human0.98677857
93NOTCH1_21737748_ChIP-Seq_TLL_Human0.97422887
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.96141415
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96125166
96PHF8_20622853_ChIP-Seq_HELA_Human0.95719666
97CDX2_22108803_ChIP-Seq_LS180_Human0.95459234
98ETV1_20927104_ChIP-Seq_GIST48_Human0.94411862
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94028006
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91566877
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90338446
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83604856
103IRF8_22096565_ChIP-ChIP_GC-B_Human0.82187191
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82113547
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80917941
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79163943
107GATA4_25053715_ChIP-Seq_YYC3_Human0.79151588
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78803186
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77668686
110ZNF263_19887448_ChIP-Seq_K562_Human0.77118607
111* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77068500
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76751511
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.76193280
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73274085
115Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72135275
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70440480
117SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67095689
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.66203113
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65790056
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.65228394
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63100032
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62989842
123NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62989842
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62405451
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62248802
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61353883
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59445827
128NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.58440707
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.57250048
130CEBPB_22108803_ChIP-Seq_LS180_Human0.56780846
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53493199
132EGR1_19032775_ChIP-ChIP_M12_Human0.53471551
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.52147905
134* LXR_22292898_ChIP-Seq_THP-1_Human0.51869666
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51629777
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51007797
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50683604
138MYC_19915707_ChIP-ChIP_AK7_Human0.50651269
139AR_20517297_ChIP-Seq_VCAP_Human0.50274940
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.49416508
141CBP_21632823_ChIP-Seq_H3396_Human0.47506769
142STAT1_17558387_ChIP-Seq_HELA_Human0.47466216
143P53_21459846_ChIP-Seq_SAOS-2_Human0.45930404
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45365368
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44534683
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.43898108
147TAF15_26573619_Chip-Seq_HEK293_Human0.42621550
148ERG_21242973_ChIP-ChIP_JURKAT_Human0.42395837
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41728820
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.41636841
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41132814
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.40957118
153FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.40787401
154TAF2_19829295_ChIP-Seq_ESCs_Human0.40649269
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.39533967
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39113006
157STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38604184
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.38317704
159MYC_27129775_Chip-Seq_CORNEA_Mouse0.38132620
160BCAT_22108803_ChIP-Seq_LS180_Human0.38096334
161GATA2_19941826_ChIP-Seq_K562_Human0.37993467
162ESR1_20079471_ChIP-ChIP_T-47D_Human0.37809426
163SPI1_26923725_Chip-Seq_HPCs_Mouse0.36979850
164FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.36392343
165LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36187070
166* GATA6_25053715_ChIP-Seq_YYC3_Human0.35522042
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35054780
168CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34209019
169* GATA1_19941826_ChIP-Seq_K562_Human0.34090686
170NCOR_22424771_ChIP-Seq_293T_Human0.33408629
171FOXH1_21741376_ChIP-Seq_EPCs_Human0.32561957
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.32350303
173SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32233171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.38303773
2MP0005360_urolithiasis7.60299202
3* MP0005085_abnormal_gallbladder_physiolo6.25734762
4MP0005365_abnormal_bile_salt6.24315993
5MP0008875_abnormal_xenobiotic_pharmacok5.20647577
6MP0003806_abnormal_nucleotide_metabolis4.29769508
7MP0003252_abnormal_bile_duct3.94215108
8MP0010329_abnormal_lipoprotein_level3.61253697
9MP0009840_abnormal_foam_cell3.32079633
10MP0005083_abnormal_biliary_tract3.10445470
11MP0003195_calcinosis2.84284405
12MP0005332_abnormal_amino_acid2.77388970
13MP0001666_abnormal_nutrient_absorption2.59891620
14MP0003191_abnormal_cellular_cholesterol2.30322152
15* MP0000609_abnormal_liver_physiology2.15074339
16MP0004019_abnormal_vitamin_homeostasis2.14684210
17* MP0002118_abnormal_lipid_homeostasis2.08751325
18MP0002138_abnormal_hepatobiliary_system1.95063551
19MP0003868_abnormal_feces_composition1.94443433
20MP0005319_abnormal_enzyme/_coenzyme1.84442044
21MP0005551_abnormal_eye_electrophysiolog1.80670078
22MP0006292_abnormal_olfactory_placode1.70421222
23MP0001764_abnormal_homeostasis1.69287389
24MP0001986_abnormal_taste_sensitivity1.69244134
25MP0009697_abnormal_copulation1.62031406
26MP0001968_abnormal_touch/_nociception1.60553478
27MP0005584_abnormal_enzyme/coenzyme_acti1.57170008
28MP0004043_abnormal_pH_regulation1.51258866
29MP0005451_abnormal_body_composition1.46415256
30MP0003646_muscle_fatigue1.46409343
31MP0009745_abnormal_behavioral_response1.42008861
32MP0003011_delayed_dark_adaptation1.39772280
33MP0004142_abnormal_muscle_tone1.39039720
34MP0005646_abnormal_pituitary_gland1.35844719
35MP0002736_abnormal_nociception_after1.30640000
36MP0003186_abnormal_redox_activity1.27325816
37MP0003656_abnormal_erythrocyte_physiolo1.26549928
38MP0003136_yellow_coat_color1.26328299
39MP0009643_abnormal_urine_homeostasis1.21264248
40MP0002653_abnormal_ependyma_morphology1.17673237
41MP0009046_muscle_twitch1.16982233
42* MP0000598_abnormal_liver_morphology1.16264373
43MP0005647_abnormal_sex_gland1.15812213
44MP0003705_abnormal_hypodermis_morpholog1.15064405
45MP0004147_increased_porphyrin_level1.13587305
46MP0002638_abnormal_pupillary_reflex1.13359309
47MP0002102_abnormal_ear_morphology1.12786658
48MP0008877_abnormal_DNA_methylation1.08067792
49MP0000604_amyloidosis1.07443435
50MP0001501_abnormal_sleep_pattern1.05900794
51MP0009764_decreased_sensitivity_to1.05524553
52MP0001485_abnormal_pinna_reflex1.05485099
53MP0009763_increased_sensitivity_to1.02277793
54MP0002272_abnormal_nervous_system1.02161889
55MP0002254_reproductive_system_inflammat1.00926061
56MP0006276_abnormal_autonomic_nervous0.97748662
57MP0005645_abnormal_hypothalamus_physiol0.97286817
58MP0002735_abnormal_chemical_nociception0.94289370
59MP0010368_abnormal_lymphatic_system0.93055625
60MP0004133_heterotaxia0.90706825
61MP0002064_seizures0.89990570
62MP0005636_abnormal_mineral_homeostasis0.89747248
63MP0005377_hearing/vestibular/ear_phenot0.89097847
64MP0003878_abnormal_ear_physiology0.89097847
65MP0001984_abnormal_olfaction0.88814766
66MP0002938_white_spotting0.88705582
67MP0008469_abnormal_protein_level0.88673727
68MP0005253_abnormal_eye_physiology0.87195306
69MP0000427_abnormal_hair_cycle0.86849599
70* MP0009642_abnormal_blood_homeostasis0.85946196
71MP0000569_abnormal_digit_pigmentation0.85822390
72MP0001486_abnormal_startle_reflex0.85735619
73MP0005408_hypopigmentation0.84327916
74MP0006036_abnormal_mitochondrial_physio0.82118237
75MP0004145_abnormal_muscle_electrophysio0.81957160
76MP0005187_abnormal_penis_morphology0.81167366
77MP0006072_abnormal_retinal_apoptosis0.81053359
78MP0005376_homeostasis/metabolism_phenot0.80482923
79MP0010386_abnormal_urinary_bladder0.80087835
80MP0005670_abnormal_white_adipose0.79587510
81MP0002572_abnormal_emotion/affect_behav0.79439117
82MP0009765_abnormal_xenobiotic_induced0.78273724
83MP0003879_abnormal_hair_cell0.76575606
84MP0002876_abnormal_thyroid_physiology0.75154865
85* MP0002078_abnormal_glucose_homeostasis0.74710620
86MP0002234_abnormal_pharynx_morphology0.74518085
87MP0005084_abnormal_gallbladder_morpholo0.74210635
88MP0005220_abnormal_exocrine_pancreas0.72865341
89MP0002971_abnormal_brown_adipose0.72240884
90MP0002282_abnormal_trachea_morphology0.70782199
91MP0002557_abnormal_social/conspecific_i0.70746332
92MP0005174_abnormal_tail_pigmentation0.70108090
93MP0004130_abnormal_muscle_cell0.69536641
94MP0002733_abnormal_thermal_nociception0.69035408
95MP0004924_abnormal_behavior0.68789759
96MP0005386_behavior/neurological_phenoty0.68789759
97MP0004885_abnormal_endolymph0.68396302
98MP0001661_extended_life_span0.67765278
99MP0003690_abnormal_glial_cell0.67718556
100MP0001970_abnormal_pain_threshold0.67559742
101MP0005195_abnormal_posterior_eye0.66511148
102MP0005266_abnormal_metabolism0.66064769
103MP0009053_abnormal_anal_canal0.65943192
104MP0002160_abnormal_reproductive_system0.64786340
105MP0003787_abnormal_imprinting0.64046497
106MP0003880_abnormal_central_pattern0.63777909
107MP0003329_amyloid_beta_deposits0.62991122
108MP0000639_abnormal_adrenal_gland0.62314743
109MP0000631_abnormal_neuroendocrine_gland0.61398604
110* MP0005334_abnormal_fat_pad0.60600560
111MP0008995_early_reproductive_senescence0.59804255
112MP0005410_abnormal_fertilization0.59787973
113MP0005167_abnormal_blood-brain_barrier0.59779351
114MP0006035_abnormal_mitochondrial_morpho0.56823456
115MP0001756_abnormal_urination0.56622841
116* MP0005535_abnormal_body_temperature0.55990457
117MP0005464_abnormal_platelet_physiology0.52688355
118MP0002822_catalepsy0.49304433
119MP0005395_other_phenotype0.49153035
120MP0003718_maternal_effect0.48958106
121MP0003638_abnormal_response/metabolism_0.46419920
122MP0008874_decreased_physiological_sensi0.46373044
123MP0008873_increased_physiological_sensi0.45495577
124MP0002928_abnormal_bile_duct0.45186529
125* MP0005448_abnormal_energy_balance0.44243881
126MP0004782_abnormal_surfactant_physiolog0.44146948
127MP0002136_abnormal_kidney_physiology0.43205268
128MP0003436_decreased_susceptibility_to0.42424084
129MP0003724_increased_susceptibility_to0.41466458
130MP0004381_abnormal_hair_follicle0.41061308
131MP0005248_abnormal_Harderian_gland0.40847824
132MP0003075_altered_response_to0.40687815
133MP0002837_dystrophic_cardiac_calcinosis0.39126177
134* MP0003953_abnormal_hormone_level0.38244732
135MP0008872_abnormal_physiological_respon0.37902912
136MP0005166_decreased_susceptibility_to0.37478201
137MP0000579_abnormal_nail_morphology0.37401397
138MP0009672_abnormal_birth_weight0.36949751
139MP0005666_abnormal_adipose_tissue0.36589635
140MP0002796_impaired_skin_barrier0.34035972
141MP0009115_abnormal_fat_cell0.33605994
142MP0006082_CNS_inflammation0.33281108
143MP0000249_abnormal_blood_vessel0.31844086
144MP0001243_abnormal_dermal_layer0.31359185
145MP0002970_abnormal_white_adipose0.30990900
146MP0002168_other_aberrant_phenotype0.30468803
147MP0009384_cardiac_valve_regurgitation0.30318006
148MP0004883_abnormal_blood_vessel0.30255075
149MP0001853_heart_inflammation0.30221310
150MP0000230_abnormal_systemic_arterial0.29999325
151MP0001881_abnormal_mammary_gland0.27556369
152MP0001845_abnormal_inflammatory_respons0.27486966
153MP0002060_abnormal_skin_morphology0.24693549
154MP0002132_abnormal_respiratory_system0.24146692
155MP0005058_abnormal_lysosome_morphology0.24076825
156MP0005164_abnormal_response_to0.23881918

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.47445254
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.46785323
3Intrahepatic cholestasis (HP:0001406)7.35829527
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.74637265
5Prolonged partial thromboplastin time (HP:0003645)6.62882185
6Hypobetalipoproteinemia (HP:0003563)6.51482618
7Xanthomatosis (HP:0000991)6.30932957
8Hyperlipoproteinemia (HP:0010980)5.62808310
9Complement deficiency (HP:0004431)5.40174655
10Hypolipoproteinemia (HP:0010981)4.83603182
11Joint hemorrhage (HP:0005261)4.83345337
12Hyperammonemia (HP:0001987)4.62249104
13Epidermoid cyst (HP:0200040)4.57243678
14Hyperglycinemia (HP:0002154)4.46169053
15Abnormality of the common coagulation pathway (HP:0010990)4.45325098
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.42290804
17Abnormality of methionine metabolism (HP:0010901)4.34094195
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.27868575
19Ketosis (HP:0001946)4.24888242
20Hypoalphalipoproteinemia (HP:0003233)4.19601716
21Fat malabsorption (HP:0002630)4.15507774
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15215064
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14743912
24Abnormality of complement system (HP:0005339)3.94270220
25Hyperglycinuria (HP:0003108)3.93003559
26Abnormality of glycine metabolism (HP:0010895)3.91980191
27Abnormality of serine family amino acid metabolism (HP:0010894)3.91980191
28Abnormality of pyrimidine metabolism (HP:0004353)3.89507300
29Hypoglycemic coma (HP:0001325)3.81320948
30Abnormality of the intrinsic pathway (HP:0010989)3.77942809
31Conjugated hyperbilirubinemia (HP:0002908)3.74691652
32Hypercholesterolemia (HP:0003124)3.65001571
33Pancreatic cysts (HP:0001737)3.61137275
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37370278
35Hyperbilirubinemia (HP:0002904)3.35015855
36Abnormality of fatty-acid metabolism (HP:0004359)3.31676771
37Pancreatic fibrosis (HP:0100732)3.22522705
38Abnormality of alanine metabolism (HP:0010916)3.14806134
39Hyperalaninemia (HP:0003348)3.14806134
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14806134
41Fair hair (HP:0002286)3.14058076
42Steatorrhea (HP:0002570)3.13840671
43Delayed CNS myelination (HP:0002188)3.11499462
44Abnormality of serum amino acid levels (HP:0003112)3.10162761
45Abnormality of midbrain morphology (HP:0002418)3.07366857
46Molar tooth sign on MRI (HP:0002419)3.07366857
47Abnormality of nucleobase metabolism (HP:0010932)3.06754222
48Hypochromic microcytic anemia (HP:0004840)3.03320347
49Spontaneous abortion (HP:0005268)3.01066340
50Myocardial infarction (HP:0001658)2.99081782
51Ketoacidosis (HP:0001993)2.99063221
52Hepatocellular carcinoma (HP:0001402)2.98941370
53Congenital stationary night blindness (HP:0007642)2.95510954
54True hermaphroditism (HP:0010459)2.92044697
55Hyperventilation (HP:0002883)2.86754322
56Bile duct proliferation (HP:0001408)2.81795628
57Abnormal biliary tract physiology (HP:0012439)2.81795628
58Skin nodule (HP:0200036)2.81645860
59Chronic hepatic failure (HP:0100626)2.77338754
60Metabolic acidosis (HP:0001942)2.74139520
61Systemic lupus erythematosus (HP:0002725)2.73245714
62Abnormality of purine metabolism (HP:0004352)2.65377684
63Nephronophthisis (HP:0000090)2.61830077
64Lethargy (HP:0001254)2.61044143
65Acanthocytosis (HP:0001927)2.57852187
66Vascular calcification (HP:0004934)2.57194605
67Dicarboxylic aciduria (HP:0003215)2.55614750
68Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55614750
69Abnormality of the renal cortex (HP:0011035)2.54958535
70Attenuation of retinal blood vessels (HP:0007843)2.52302983
71Abnormal gallbladder morphology (HP:0012437)2.48401379
72Spastic diplegia (HP:0001264)2.48053090
73Cystic liver disease (HP:0006706)2.46892024
74Glomerulonephritis (HP:0000099)2.45947903
75Hypoglycemic seizures (HP:0002173)2.44689545
76Mitral stenosis (HP:0001718)2.42308396
77Gout (HP:0001997)2.41881409
78Cerebral edema (HP:0002181)2.41827118
79Cholelithiasis (HP:0001081)2.41562684
80Abnormal gallbladder physiology (HP:0012438)2.37177202
81Cholecystitis (HP:0001082)2.37177202
82Irritability (HP:0000737)2.36909522
83Recurrent gram-negative bacterial infections (HP:0005420)2.36601067
84Neonatal onset (HP:0003623)2.35038439
85Generalized hypopigmentation of hair (HP:0011358)2.31023258
86Type II lissencephaly (HP:0007260)2.29567602
87Cardiovascular calcification (HP:0011915)2.27742149
88Amyloidosis (HP:0011034)2.26428472
89Abolished electroretinogram (ERG) (HP:0000550)2.26215764
90Malnutrition (HP:0004395)2.24932500
91Abnormality of the renal medulla (HP:0100957)2.22026496
92Esophageal varix (HP:0002040)2.20792603
93Gingival bleeding (HP:0000225)2.20131738
94Genetic anticipation (HP:0003743)2.16354093
95Menorrhagia (HP:0000132)2.16279648
96Brushfield spots (HP:0001088)2.14564437
97Glycosuria (HP:0003076)2.12669849
98Abnormality of urine glucose concentration (HP:0011016)2.12669849
99Sensorimotor neuropathy (HP:0007141)2.12236660
100Pancreatitis (HP:0001733)2.11481792
101Late onset (HP:0003584)2.09997482
102Progressive cerebellar ataxia (HP:0002073)2.09704202
103Acute encephalopathy (HP:0006846)2.08812723
104Enlarged kidneys (HP:0000105)2.08676499
105Medial flaring of the eyebrow (HP:0010747)2.08577971
106Decreased central vision (HP:0007663)2.08356476
107Thrombophlebitis (HP:0004418)2.07337470
108Vomiting (HP:0002013)2.04731536
109Opisthotonus (HP:0002179)2.04105280
110Pendular nystagmus (HP:0012043)2.02609774
111Poikilocytosis (HP:0004447)2.01600091
112Abnormality of the gallbladder (HP:0005264)2.01392582
113Generalized aminoaciduria (HP:0002909)2.00670607
114Hemorrhage of the eye (HP:0011885)1.99861192
115Tubular atrophy (HP:0000092)1.98548565
116Large for gestational age (HP:0001520)1.98202165
117Hyperinsulinemic hypoglycemia (HP:0000825)1.97372405
118Gaze-evoked nystagmus (HP:0000640)1.95428544
119Rickets (HP:0002748)1.93984235
120Reduced antithrombin III activity (HP:0001976)1.91674648
121Arthropathy (HP:0003040)1.91495446
122Abnormal cartilage morphology (HP:0002763)1.88504327
123Congenital hepatic fibrosis (HP:0002612)1.88377607
124Abnormality of iron homeostasis (HP:0011031)1.88020561
125Methylmalonic acidemia (HP:0002912)1.87029618
126Inability to walk (HP:0002540)1.85813202
127Abnormality of transition element cation homeostasis (HP:0011030)1.85125831
128Hypophosphatemic rickets (HP:0004912)1.84672062
129Renal cortical cysts (HP:0000803)1.84144540
130Sclerocornea (HP:0000647)1.83975373
131Hydroxyprolinuria (HP:0003080)1.82450075
132Abnormality of proline metabolism (HP:0010907)1.82450075
133Abnormal enzyme/coenzyme activity (HP:0012379)1.82263378
134Alkalosis (HP:0001948)1.80975544
135Status epilepticus (HP:0002133)1.80487597
136Elevated hepatic transaminases (HP:0002910)1.80295255
137Increased CSF lactate (HP:0002490)1.80112658
138Birth length less than 3rd percentile (HP:0003561)1.79845749
139Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76665297
140Nephritis (HP:0000123)1.75236530
141Abnormal drinking behavior (HP:0030082)1.74731645
142Polydipsia (HP:0001959)1.74731645
143Abnormality of vitamin metabolism (HP:0100508)1.73881068
144Acute necrotizing encephalopathy (HP:0006965)1.73725399
145Hyperglycemia (HP:0003074)1.73614805
146Hepatic necrosis (HP:0002605)1.73511489
147Dynein arm defect of respiratory motile cilia (HP:0012255)1.73082982
148Absent/shortened dynein arms (HP:0200106)1.73082982
149Chorioretinal atrophy (HP:0000533)1.72960386
150Male pseudohermaphroditism (HP:0000037)1.71761067
151Methylmalonic aciduria (HP:0012120)1.71547227
152Mitochondrial inheritance (HP:0001427)1.71323709
153Severe muscular hypotonia (HP:0006829)1.70741487
154Neonatal hypoglycemia (HP:0001998)1.67745390
155Protruding tongue (HP:0010808)1.67588939
156Bony spicule pigmentary retinopathy (HP:0007737)1.67314068

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.16634742
2SIK14.62151947
3FGFR44.60934498
4ERN14.29044051
5BMPR1B3.37011391
6TAOK33.07774614
7ADRBK23.07253290
8ACVR1B3.03287907
9ZAK3.02884000
10ERBB42.96107971
11INSRR2.95789901
12TLK12.59032101
13WNK42.58731774
14WNK32.45511961
15MAP4K22.38086323
16MAP2K42.33717718
17PKN22.24916372
18MST1R2.09323471
19NUAK11.95786345
20FLT31.95084418
21MAPK111.93441616
22PIK3CG1.78242384
23TRIB31.73520230
24TYK21.70512595
25CASK1.69965349
26MAPK131.68901855
27LATS11.67037856
28OXSR11.65817691
29MAP3K41.58763147
30ABL21.50438289
31DAPK21.50103325
32PTK61.43248977
33TXK1.43223392
34FGFR21.41436226
35NEK91.35677495
36NTRK31.35176361
37FRK1.33599434
38ADRBK11.31341016
39PINK11.30772425
40KDR1.30130799
41MKNK21.26115185
42JAK21.23682714
43STK391.19908708
44MAP3K71.18184470
45PRKAA21.14081970
46TGFBR11.12743806
47DYRK21.09562461
48PIK3CA1.08067463
49TNIK1.06370193
50CAMKK21.05733660
51MAP2K31.05301120
52MAPK151.04774199
53GRK61.04757275
54TBK11.03232153
55ERBB21.02366245
56MAPK41.01636297
57MAP3K101.00947317
58JAK11.00460208
59MAP3K140.96266099
60PAK30.94740811
61PRKCZ0.94541486
62TNK20.90218233
63STK160.89330095
64STK38L0.89282903
65MAP3K110.88565435
66MET0.86064660
67CDK60.85552546
68PRKCE0.85229407
69MAP3K30.84851250
70MUSK0.83818233
71VRK10.83630785
72MAPKAPK30.82256880
73MAPK120.79398370
74EPHB10.79056154
75CSK0.78899771
76PRKACG0.76574995
77DYRK1B0.75956419
78MAP2K70.75314201
79TIE10.74647582
80CAMK2G0.74507296
81RPS6KA50.70879007
82EPHA30.70865022
83GSK3A0.70807774
84PRKAA10.68819956
85CAMK1D0.68461022
86MAP2K60.67001459
87PHKG20.66599048
88PHKG10.66599048
89PRKACA0.64193710
90SGK30.63078826
91IRAK30.60054745
92RIPK10.60030250
93BRSK20.59215817
94MAPKAPK50.58843280
95MAPK70.58238244
96ICK0.57470899
97MARK10.57320559
98PDK20.56787491
99TEC0.56369219
100STK110.56168681
101FGFR30.55702655
102CSF1R0.55553964
103IKBKB0.54961942
104TGFBR20.54532354
105PTK20.54248981
106MAP3K60.53827486
107TRIM280.53752734
108CSNK1G10.53435985
109IKBKE0.52961123
110NME10.51946172
111TAOK20.51916520
112CSNK1A10.50738058
113CSNK1D0.50299074
114PTK2B0.50128684
115PRKCQ0.50013121
116PDPK10.49965363
117EPHA40.48927004
118SGK20.44626361
119CAMK10.44484904
120PNCK0.44454186
121MAP3K50.44438306
122GRK10.43789435
123IGF1R0.42470881
124CDK40.41952835
125PRKG10.41732243
126CAMK2A0.41396856
127PRKCG0.40388996
128ATR0.40080722
129MAP2K10.39643119
130PKN10.39415722
131MKNK10.39184568
132RET0.39017149
133NLK0.38967337
134MAP3K130.38845849
135MTOR0.37327395
136SIK20.36933887
137PLK20.35780629
138EGFR0.35578072
139CHUK0.35004912
140CAMK1G0.34364763
141PRKCI0.34290607
142LATS20.33347943
143NEK20.32722279
144DYRK1A0.32386507
145OBSCN0.32280492
146SGK10.31581002
147CAMK40.31434088
148CAMKK10.31379070
149CSNK1G20.31321497
150PBK0.31084452
151PDK10.30500278
152PRKACB0.30221402
153VRK20.30094392
154SGK2230.29513339
155SGK4940.29513339
156RPS6KA30.29456842
157CSNK1G30.29088464
158BMX0.27925535
159PRKCA0.25376835
160IRAK20.24250115
161AKT30.23373052
162ABL10.22582794
163IRAK10.22249393
164MAP3K10.22059987
165MAP2K20.19997845
166CSNK1A1L0.19733077
167PDK30.19694512

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.38719994
2Nitrogen metabolism_Homo sapiens_hsa009103.62928220
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.40458081
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38790067
5Arginine biosynthesis_Homo sapiens_hsa002203.11276385
6Complement and coagulation cascades_Homo sapiens_hsa046102.77827953
7Tryptophan metabolism_Homo sapiens_hsa003802.70200744
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69730414
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63072663
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55777787
11Fatty acid degradation_Homo sapiens_hsa000712.47746312
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37324851
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28273740
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15732981
15Butanoate metabolism_Homo sapiens_hsa006502.14302694
16Peroxisome_Homo sapiens_hsa041462.07867880
17Chemical carcinogenesis_Homo sapiens_hsa052041.97240107
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.95559051
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95207270
20Propanoate metabolism_Homo sapiens_hsa006401.91452739
21Histidine metabolism_Homo sapiens_hsa003401.91181134
22Fatty acid metabolism_Homo sapiens_hsa012121.80589125
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.80215805
24Caffeine metabolism_Homo sapiens_hsa002321.78503914
25* PPAR signaling pathway_Homo sapiens_hsa033201.77674722
26Staphylococcus aureus infection_Homo sapiens_hsa051501.77373760
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76500216
28Retinol metabolism_Homo sapiens_hsa008301.73366200
29beta-Alanine metabolism_Homo sapiens_hsa004101.71263541
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67724160
31Selenocompound metabolism_Homo sapiens_hsa004501.59296127
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57576348
33Phenylalanine metabolism_Homo sapiens_hsa003601.56856018
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52529504
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51391096
36Tyrosine metabolism_Homo sapiens_hsa003501.44677187
37* Bile secretion_Homo sapiens_hsa049761.40262450
38Pyruvate metabolism_Homo sapiens_hsa006201.35289105
39Sulfur metabolism_Homo sapiens_hsa009201.34785095
40Fatty acid elongation_Homo sapiens_hsa000621.33518539
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.32957541
42Starch and sucrose metabolism_Homo sapiens_hsa005001.29561910
43Steroid biosynthesis_Homo sapiens_hsa001001.23293135
44Folate biosynthesis_Homo sapiens_hsa007901.22650216
45Biosynthesis of amino acids_Homo sapiens_hsa012301.22096006
46ABC transporters_Homo sapiens_hsa020101.20709307
47Fat digestion and absorption_Homo sapiens_hsa049751.15113698
48Carbon metabolism_Homo sapiens_hsa012001.12205377
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05898026
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.00668170
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.98585693
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97984755
53Vitamin B6 metabolism_Homo sapiens_hsa007500.97654548
54Arginine and proline metabolism_Homo sapiens_hsa003300.97461120
55Sulfur relay system_Homo sapiens_hsa041220.96270560
56Phototransduction_Homo sapiens_hsa047440.89931892
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87956599
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85978402
59Vitamin digestion and absorption_Homo sapiens_hsa049770.84765402
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83372937
61Lysine degradation_Homo sapiens_hsa003100.81394462
62One carbon pool by folate_Homo sapiens_hsa006700.77536931
63Oxidative phosphorylation_Homo sapiens_hsa001900.75657800
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69245825
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67051336
66Glycerolipid metabolism_Homo sapiens_hsa005610.66872773
67Nicotine addiction_Homo sapiens_hsa050330.65305861
68Glutathione metabolism_Homo sapiens_hsa004800.65071894
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58764176
70Ether lipid metabolism_Homo sapiens_hsa005650.57933739
71Fatty acid biosynthesis_Homo sapiens_hsa000610.57915722
72Pentose phosphate pathway_Homo sapiens_hsa000300.57325081
73RNA polymerase_Homo sapiens_hsa030200.51981112
74Homologous recombination_Homo sapiens_hsa034400.50703746
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50617936
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47860394
77Serotonergic synapse_Homo sapiens_hsa047260.47389632
78Parkinsons disease_Homo sapiens_hsa050120.46947788
79* Metabolic pathways_Homo sapiens_hsa011000.45533358
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45439058
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39818186
82Fanconi anemia pathway_Homo sapiens_hsa034600.38804539
83Prion diseases_Homo sapiens_hsa050200.37260352
84Taste transduction_Homo sapiens_hsa047420.31303542
85GABAergic synapse_Homo sapiens_hsa047270.30417522
86Huntingtons disease_Homo sapiens_hsa050160.27170837
87Morphine addiction_Homo sapiens_hsa050320.25682500
88Galactose metabolism_Homo sapiens_hsa000520.25044068
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24863628
90Fructose and mannose metabolism_Homo sapiens_hsa000510.23787693
91Olfactory transduction_Homo sapiens_hsa047400.23738228
92Linoleic acid metabolism_Homo sapiens_hsa005910.22543088
93Protein export_Homo sapiens_hsa030600.22293814
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.21571411
95Glutamatergic synapse_Homo sapiens_hsa047240.21357773
96Alzheimers disease_Homo sapiens_hsa050100.19659975
97Insulin secretion_Homo sapiens_hsa049110.19411577
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19286366
99Mineral absorption_Homo sapiens_hsa049780.18777212
100Basal transcription factors_Homo sapiens_hsa030220.18204733
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.16257888
102* Insulin resistance_Homo sapiens_hsa049310.16088244
103Pyrimidine metabolism_Homo sapiens_hsa002400.12879907
104Glucagon signaling pathway_Homo sapiens_hsa049220.09437875
105Cardiac muscle contraction_Homo sapiens_hsa042600.09318631
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.08381239
107Purine metabolism_Homo sapiens_hsa002300.07139985
108RNA degradation_Homo sapiens_hsa030180.07032905
109AMPK signaling pathway_Homo sapiens_hsa041520.02005547
110Bladder cancer_Homo sapiens_hsa05219-0.2499695
111Amoebiasis_Homo sapiens_hsa05146-0.2410437
112Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2316896
113Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2314447
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2308138
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2035115
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2006871
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1983055
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1955635
119Hepatitis C_Homo sapiens_hsa05160-0.1828161
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1688023
121Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1539777
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1537000
123Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1460439
124African trypanosomiasis_Homo sapiens_hsa05143-0.1435228
125Regulation of autophagy_Homo sapiens_hsa04140-0.1308495
126Insulin signaling pathway_Homo sapiens_hsa04910-0.0993467
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0958222
128Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0720124
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0683170
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0514788

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