SLC27A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)8.73360983
2sarcomere organization (GO:0045214)7.25139544
3cardiac myofibril assembly (GO:0055003)7.18289804
4regulation of cardioblast differentiation (GO:0051890)7.11143646
5regulation of actin filament-based movement (GO:1903115)6.60693278
6cardiac muscle contraction (GO:0060048)6.56709452
7ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.42080377
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.37600936
9negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.28560806
10ventricular cardiac muscle cell action potential (GO:0086005)6.27201062
11myofibril assembly (GO:0030239)6.25974118
12actin-myosin filament sliding (GO:0033275)6.21010610
13muscle filament sliding (GO:0030049)6.21010610
14cardiac muscle tissue morphogenesis (GO:0055008)6.04368579
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.97760602
16cardiac muscle hypertrophy (GO:0003300)5.71020330
17cardiac muscle cell development (GO:0055013)5.69132361
18cell communication involved in cardiac conduction (GO:0086065)5.68173610
19regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.57214935
20regulation of the force of heart contraction (GO:0002026)5.54459687
21regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.48803547
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.46136896
23cell communication by electrical coupling (GO:0010644)5.39893609
24striated muscle hypertrophy (GO:0014897)5.36857008
25muscle tissue morphogenesis (GO:0060415)5.36836428
26cardiac cell development (GO:0055006)5.34508088
27actin-mediated cell contraction (GO:0070252)5.27448808
28cardiac chamber formation (GO:0003207)5.17727460
29regulation of relaxation of muscle (GO:1901077)5.12065810
30adult heart development (GO:0007512)5.08294134
31negative regulation of potassium ion transmembrane transport (GO:1901380)4.95223020
32actomyosin structure organization (GO:0031032)4.93325652
33negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.92116353
34respiratory tube development (GO:0030323)4.88594350
35regulation of cardiac muscle cell contraction (GO:0086004)4.88507944
36endocardial cushion development (GO:0003197)4.82227239
37protein heterotrimerization (GO:0070208)4.76898616
38relaxation of cardiac muscle (GO:0055119)4.75894063
39bone trabecula formation (GO:0060346)4.74089799
40muscle hypertrophy (GO:0014896)4.70443458
41atrial septum morphogenesis (GO:0060413)4.68766292
42regulation of ATPase activity (GO:0043462)4.63982850
43regulation of ATP catabolic process (GO:1903289)4.63982850
44cardiac muscle cell action potential (GO:0086001)4.63204347
45ventricular cardiac muscle cell development (GO:0055015)4.53435005
46regulation of heart rate (GO:0002027)4.52443455
47cardiac muscle cell action potential involved in contraction (GO:0086002)4.49283673
48striated muscle contraction (GO:0006941)4.47736276
49cardiac ventricle formation (GO:0003211)4.40567016
50negative regulation of striated muscle cell apoptotic process (GO:0010664)4.38453168
51heart process (GO:0003015)4.35935804
52heart contraction (GO:0060047)4.35935804
53anatomical structure regression (GO:0060033)4.34643187
54regulation of striated muscle contraction (GO:0006942)4.30182656
55definitive hemopoiesis (GO:0060216)4.22535798
56positive regulation of ATP catabolic process (GO:1903291)4.19267215
57positive regulation of ATPase activity (GO:0032781)4.19267215
58gonadal mesoderm development (GO:0007506)4.18582800
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.09001686
60lung vasculature development (GO:0060426)4.08794884
61cardiac muscle tissue development (GO:0048738)4.02287733
62insulin-like growth factor receptor signaling pathway (GO:0048009)3.99748118
63hemidesmosome assembly (GO:0031581)3.97224720
64extracellular fibril organization (GO:0043206)3.93510377
65actin filament-based movement (GO:0030048)3.90196344
66cardiac conduction (GO:0061337)3.86010893
67outflow tract septum morphogenesis (GO:0003148)3.83831248
68positive regulation of male gonad development (GO:2000020)3.83096534
69fibril organization (GO:0097435)3.75575546
70cardiac muscle hypertrophy in response to stress (GO:0014898)3.74864343
71muscle hypertrophy in response to stress (GO:0003299)3.74864343
72cardiac muscle adaptation (GO:0014887)3.74864343
73regulation of heart contraction (GO:0008016)3.74549900
74regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.67318138
75positive regulation of cardiac muscle cell proliferation (GO:0060045)3.67058268
76dorsal/ventral axis specification (GO:0009950)3.66665093
77regulation of cardiac muscle contraction (GO:0055117)3.66343214
78sarcoplasmic reticulum calcium ion transport (GO:0070296)3.66204463
79positive regulation of cardiac muscle tissue growth (GO:0055023)3.60371408
80cardiac right ventricle morphogenesis (GO:0003215)3.59336432
81regulation of cardiac muscle cell apoptotic process (GO:0010665)3.54182603
82sex determination (GO:0007530)3.51951046
83growth hormone receptor signaling pathway (GO:0060396)3.51771522
84heparin biosynthetic process (GO:0030210)3.50214791
85heparin metabolic process (GO:0030202)3.50214791
86regulation of cell communication by electrical coupling (GO:0010649)3.49346620
87relaxation of smooth muscle (GO:0044557)3.48187600
88cell migration involved in heart development (GO:0060973)3.46718375
89mesodermal cell differentiation (GO:0048333)3.45871664
90polarized epithelial cell differentiation (GO:0030859)3.43952677
91negative regulation of catenin import into nucleus (GO:0035414)3.39959950
92positive regulation of cardiac muscle tissue development (GO:0055025)3.36383900
93positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.36346804
94regulation of heart rate by cardiac conduction (GO:0086091)3.36208122
95embryonic heart tube development (GO:0035050)3.35770819
96detection of calcium ion (GO:0005513)3.32699202
97adrenergic receptor signaling pathway (GO:0071875)3.32197914
98gap junction assembly (GO:0016264)3.30258657
99negative regulation of fibroblast apoptotic process (GO:2000270)3.28837463
100regulation of male gonad development (GO:2000018)3.28300463
101relaxation of muscle (GO:0090075)3.26393380
102genitalia morphogenesis (GO:0035112)3.25442842
103regulation of heart morphogenesis (GO:2000826)3.24913713
104negative regulation of chondrocyte differentiation (GO:0032331)3.24254512
105regulation of cardiac muscle cell proliferation (GO:0060043)3.23304022
106collagen fibril organization (GO:0030199)3.23240240
107positive regulation of heart rate (GO:0010460)3.21787471
108positive regulation of heart contraction (GO:0045823)3.19160784
109blood vessel maturation (GO:0001955)3.18293493
110striated muscle cell development (GO:0055002)3.17789355
111sequestering of extracellular ligand from receptor (GO:0035581)3.16608882
112ectodermal placode formation (GO:0060788)3.15506463
113positive regulation of heart growth (GO:0060421)3.15109265
114craniofacial suture morphogenesis (GO:0097094)3.13535976
115regulation of cardiac muscle tissue development (GO:0055024)3.11244158
116midgut development (GO:0007494)3.11119815
117epithelial cell-cell adhesion (GO:0090136)3.11089333
118endocardial cushion morphogenesis (GO:0003203)3.10742947
119cellular response to growth hormone stimulus (GO:0071378)3.10589489
120regulation of cardioblast proliferation (GO:0003264)3.09098800
121regulation of secondary heart field cardioblast proliferation (GO:0003266)3.09098800
122positive regulation of developmental pigmentation (GO:0048087)3.07311744
123negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.06824952
124response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.06093061
125paraxial mesoderm development (GO:0048339)3.05903687
126regulation of membrane repolarization (GO:0060306)3.04219184
127negative regulation of erythrocyte differentiation (GO:0045647)3.04062539
128collagen catabolic process (GO:0030574)3.03900586
129germ cell migration (GO:0008354)3.03830522
130regulation of striated muscle cell apoptotic process (GO:0010662)3.03822879
131glomerular filtration (GO:0003094)3.03493782
132response to caffeine (GO:0031000)3.03063903
133skin morphogenesis (GO:0043589)3.01849219
134collagen metabolic process (GO:0032963)3.00705617
135cellular response to epinephrine stimulus (GO:0071872)2.99985542
136regulation of DNA methylation (GO:0044030)2.98698680
137regulation of muscle contraction (GO:0006937)2.97385903
138negative regulation of hormone biosynthetic process (GO:0032353)2.94709128
139glomerular basement membrane development (GO:0032836)2.92885568
140histone H3-K36 demethylation (GO:0070544)2.92070874
141response to redox state (GO:0051775)2.91069846
142glucocorticoid receptor signaling pathway (GO:0042921)2.89520075
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.88450426
144axon extension involved in axon guidance (GO:0048846)2.88450426
145regulation of pigment cell differentiation (GO:0050932)2.88317566
146diaphragm development (GO:0060539)2.87936072
147regulation of cardiac muscle tissue growth (GO:0055021)2.87658055
148atrioventricular valve morphogenesis (GO:0003181)2.87631975
149mesenchyme morphogenesis (GO:0072132)2.87625156
150cell proliferation involved in metanephros development (GO:0072203)2.83437480
151mesenchymal cell differentiation involved in renal system development (GO:2001012)2.82951427
152mesenchymal cell differentiation involved in kidney development (GO:0072161)2.82951427
153endothelial tube morphogenesis (GO:0061154)2.82266333
154morphogenesis of an endothelium (GO:0003159)2.82266333
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.79882656
156desmosome organization (GO:0002934)2.79312558
157multicellular organismal macromolecule metabolic process (GO:0044259)2.78940464
158glomerulus development (GO:0032835)2.77597526
159multicellular organismal catabolic process (GO:0044243)2.76434962
160establishment of apical/basal cell polarity (GO:0035089)2.76390728
161renal filtration (GO:0097205)2.75891259
162positive regulation of Rho protein signal transduction (GO:0035025)2.74581494
163basement membrane organization (GO:0071711)2.74313896
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71799895
165cartilage morphogenesis (GO:0060536)2.71545628
166hair cycle (GO:0042633)2.71338665
167molting cycle (GO:0042303)2.71338665
168chondrocyte proliferation (GO:0035988)2.70987938
169negative regulation of DNA repair (GO:0045738)2.70806078
170oocyte development (GO:0048599)2.69548529
171dermatan sulfate biosynthetic process (GO:0030208)2.68113865
172positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67333268
173extracellular matrix disassembly (GO:0022617)2.67042539
174renal system development (GO:0072001)2.65675077
175pericardium development (GO:0060039)2.65588504
176regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.64976344
177multicellular organismal metabolic process (GO:0044236)2.62904686
178mitotic sister chromatid cohesion (GO:0007064)2.62840761
179embryonic camera-type eye morphogenesis (GO:0048596)2.62447920
180regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62163225
181negative regulation of cartilage development (GO:0061037)2.61628047
182cell differentiation involved in metanephros development (GO:0072202)2.61295605
183embryonic digestive tract morphogenesis (GO:0048557)2.59612594
184protein localization to cell surface (GO:0034394)2.58987255
185mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.58667358
186positive regulation of mesenchymal cell proliferation (GO:0002053)2.58454974
187endodermal cell differentiation (GO:0035987)2.56997287
188regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56186248
189skeletal muscle organ development (GO:0060538)2.54002900
190fusion of sperm to egg plasma membrane (GO:0007342)2.51745205
191vascular endothelial growth factor signaling pathway (GO:0038084)2.51192747
192hepatocyte apoptotic process (GO:0097284)2.49261870
193organ formation (GO:0048645)2.48273672
194positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46576956
195adrenal gland development (GO:0030325)2.45284386
196regulation of transforming growth factor beta2 production (GO:0032909)2.45071751
197extracellular matrix assembly (GO:0085029)2.44963254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.54714405
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.47894806
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.49591344
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75358329
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.32369240
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26452805
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20325037
8CLOCK_20551151_ChIP-Seq_293T_Human3.06098949
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.04551967
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.92421622
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.84217135
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71385113
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.64690370
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.55425516
15SCL_19346495_ChIP-Seq_HPC-7_Human2.54150831
16MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.48559798
17WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.44413232
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.43067086
19TBX20_22080862_ChIP-Seq_HEART_Mouse2.43057869
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.43057869
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.40357069
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.39691647
23GATA1_22025678_ChIP-Seq_K562_Human2.33720331
24TRIM28_21343339_ChIP-Seq_HEK293_Human2.31079335
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.28770131
26TCF7_22412390_ChIP-Seq_EML_Mouse2.23498273
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23107765
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.17343638
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14026911
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.05176872
31EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.02629193
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99091402
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.97069502
34BRD4_25478319_ChIP-Seq_HGPS_Human1.91362841
35NFIB_24661679_ChIP-Seq_LUNG_Mouse1.87769978
36AR_21909140_ChIP-Seq_LNCAP_Human1.87339423
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84401787
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84258223
39GATA4_21415370_ChIP-Seq_HL-1_Mouse1.83556864
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81478209
41MYC_22102868_ChIP-Seq_BL_Human1.79706795
42E2F7_22180533_ChIP-Seq_HELA_Human1.73928440
43GBX2_23144817_ChIP-Seq_PC3_Human1.71834586
44SMAD3_21741376_ChIP-Seq_HESCs_Human1.70451203
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.69568863
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.60109794
47SMAD4_21799915_ChIP-Seq_A2780_Human1.59560332
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57545012
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57037064
50TP53_16413492_ChIP-PET_HCT116_Human1.54774256
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54683196
52* ISL1_27105846_Chip-Seq_CPCs_Mouse1.54420362
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52989758
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51328842
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49915931
56CJUN_26792858_Chip-Seq_BT549_Human1.49477606
57TAF15_26573619_Chip-Seq_HEK293_Human1.46080907
58VDR_22108803_ChIP-Seq_LS180_Human1.45718634
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45487771
60SMAD4_21741376_ChIP-Seq_HESCs_Human1.44849345
61KDM2B_26808549_Chip-Seq_DND41_Human1.44520517
62AHR_22903824_ChIP-Seq_MCF-7_Human1.44315999
63FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44280110
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.43775782
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40824784
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.40804567
67VDR_24763502_ChIP-Seq_THP-1_Human1.39060549
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38735526
69RUNX_20019798_ChIP-Seq_JUKART_Human1.38718159
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37772542
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.37588733
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36696612
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.36683450
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35837447
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34883579
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.34016975
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33762861
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33723661
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33534851
80UTX_26944678_Chip-Seq_JUKART_Human1.32831087
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31213802
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31213802
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.30523669
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30454310
85FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30215526
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28956839
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26226954
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24677526
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23843197
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23560395
91* TCF4_23295773_ChIP-Seq_U87_Human1.23142468
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22906338
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22435254
94IRF8_22096565_ChIP-ChIP_GC-B_Human1.22368566
95MAF_26560356_Chip-Seq_TH1_Human1.22067475
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21331065
97BP1_19119308_ChIP-ChIP_Hs578T_Human1.19262230
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18584458
99VDR_21846776_ChIP-Seq_THP-1_Human1.17546777
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17199948
101HTT_18923047_ChIP-ChIP_STHdh_Human1.17113497
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16580156
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16106360
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.14965105
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14644065
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14457182
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12570996
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12570996
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12570996
110* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12489494
111FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11776897
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11710034
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11400705
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11265700
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10893904
116FUS_26573619_Chip-Seq_HEK293_Human1.10283597
117TBL1_22424771_ChIP-Seq_293T_Human1.10134970
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09999950
119GF1_26923725_Chip-Seq_HPCs_Mouse1.09915149
120FOXM1_23109430_ChIP-Seq_U2OS_Human1.09577447
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09541912
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08678697
123CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08155752
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07695942
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07588514
126EWS_26573619_Chip-Seq_HEK293_Human1.07581042
127MYB_26560356_Chip-Seq_TH2_Human1.07551193
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07174225
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07051021
130SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06547511
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06236817
132STAT3_23295773_ChIP-Seq_U87_Human1.06108941
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06036435
134MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04050028
135PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03737859
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.03080266
137EZH2_27304074_Chip-Seq_ESCs_Mouse1.02935404
138TCF4_18268006_ChIP-ChIP_LS174T_Human1.01969497
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01625157
140NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01625157
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00862668
142SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00612763
143NCOR1_26117541_ChIP-Seq_K562_Human1.00561605
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00553289
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.99616104
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99069358
147MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98890697
148TAL1_26923725_Chip-Seq_HPCs_Mouse0.98826291
149P300_19829295_ChIP-Seq_ESCs_Human0.98054558
150RUNX1_27514584_Chip-Seq_MCF-7_Human0.98017762
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97705565
152MYB_26560356_Chip-Seq_TH1_Human0.97497731
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97289772
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96954152
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.96885651
156NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96691258
157TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96611078
158PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96213600
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.95641208
160SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95504338
161ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95413282
162STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93953329
163ATF3_27146783_Chip-Seq_COLON_Human0.93303653
164STAT3_18555785_ChIP-Seq_MESCs_Mouse0.93192181
165TP53_22127205_ChIP-Seq_IMR90_Human0.92182277
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92063176
167CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91306125
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91225038
169UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90599404
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.90594841
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90480140
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89319183
173* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88037938
174GATA3_24758297_ChIP-Seq_MCF-7_Human0.87553706
175EZH2_27294783_Chip-Seq_NPCs_Mouse0.87047845
176NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85751149

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.90773362
2MP0002837_dystrophic_cardiac_calcinosis5.72775618
3MP0008438_abnormal_cutaneous_collagen5.05676176
4MP0004215_abnormal_myocardial_fiber4.89311276
5MP0004036_abnormal_muscle_relaxation4.30113006
6MP0003705_abnormal_hypodermis_morpholog3.86108425
7MP0005275_abnormal_skin_tensile3.84516915
8MP0005330_cardiomyopathy3.70544515
9MP0008775_abnormal_heart_ventricle3.57315315
10MP0004272_abnormal_basement_membrane3.32457424
11MP0005503_abnormal_tendon_morphology3.23535631
12MP0002972_abnormal_cardiac_muscle2.95871212
13MP0001958_emphysema2.78895414
14MP0003137_abnormal_impulse_conducting2.65736270
15MP0004510_myositis2.41255688
16MP0010630_abnormal_cardiac_muscle2.36636252
17MP0004085_abnormal_heartbeat2.24410004
18MP0005385_cardiovascular_system_phenoty2.22631604
19MP0001544_abnormal_cardiovascular_syste2.22631604
20MP0006054_spinal_hemorrhage2.21207765
21MP0005620_abnormal_muscle_contractility2.20848393
22MP0004087_abnormal_muscle_fiber2.18293516
23MP0003115_abnormal_respiratory_system2.17042748
24MP0004145_abnormal_muscle_electrophysio2.16251348
25MP0002282_abnormal_trachea_morphology2.15767207
26MP0009384_cardiac_valve_regurgitation2.11735751
27MP0002127_abnormal_cardiovascular_syste2.11374534
28MP0003279_aneurysm2.05967078
29MP0003718_maternal_effect1.97557394
30MP0003123_paternal_imprinting1.92202904
31MP0002234_abnormal_pharynx_morphology1.89923517
32MP0003566_abnormal_cell_adhesion1.86523422
33MP0005623_abnormal_meninges_morphology1.79275632
34MP0003385_abnormal_body_wall1.79104897
35MP0005508_abnormal_skeleton_morphology1.78721487
36MP0002396_abnormal_hematopoietic_system1.76709616
37MP0002249_abnormal_larynx_morphology1.76090811
38MP0000383_abnormal_hair_follicle1.72377403
39MP0004484_altered_response_of1.70744166
40MP0009250_abnormal_appendicular_skeleto1.69625822
41MP0000537_abnormal_urethra_morphology1.69014130
42MP0000749_muscle_degeneration1.67652943
43MP0002269_muscular_atrophy1.60631643
44MP0002060_abnormal_skin_morphology1.58707149
45MP0003890_abnormal_embryonic-extraembry1.57951029
46MP0008995_early_reproductive_senescence1.55652166
47MP0008877_abnormal_DNA_methylation1.55527597
48MP0003122_maternal_imprinting1.53770188
49MP0010368_abnormal_lymphatic_system1.52847443
50MP0002938_white_spotting1.50681731
51MP0009278_abnormal_bone_marrow1.49684891
52MP0004808_abnormal_hematopoietic_stem1.45906976
53MP0000579_abnormal_nail_morphology1.41250138
54MP0005171_absent_coat_pigmentation1.40806155
55MP0002106_abnormal_muscle_physiology1.35617272
56MP0004134_abnormal_chest_morphology1.34812677
57MP0003121_genomic_imprinting1.34547447
58MP0000750_abnormal_muscle_regeneration1.33915661
59MP0010234_abnormal_vibrissa_follicle1.33441015
60MP0005023_abnormal_wound_healing1.32379056
61MP0003950_abnormal_plasma_membrane1.32140576
62MP0003942_abnormal_urinary_system1.31666776
63MP0003045_fibrosis1.27460780
64MP0001984_abnormal_olfaction1.27444743
65MP0010678_abnormal_skin_adnexa1.24803057
66MP0001243_abnormal_dermal_layer1.21971507
67MP0000647_abnormal_sebaceous_gland1.21906961
68MP0010030_abnormal_orbit_morphology1.21752787
69MP0002098_abnormal_vibrissa_morphology1.21429071
70MP0003828_pulmonary_edema1.21277561
71MP0004197_abnormal_fetal_growth/weight/1.19362159
72MP0000428_abnormal_craniofacial_morphol1.18694566
73MP0005369_muscle_phenotype1.16972556
74MP0000733_abnormal_muscle_development1.15595017
75MP0000427_abnormal_hair_cycle1.12617137
76MP0001293_anophthalmia1.10911903
77MP0000534_abnormal_ureter_morphology1.10391677
78MP0005257_abnormal_intraocular_pressure1.09633974
79MP0002128_abnormal_blood_circulation1.09633357
80MP0003221_abnormal_cardiomyocyte_apopto1.09583386
81MP0003091_abnormal_cell_migration1.07948793
82MP0003984_embryonic_growth_retardation1.07724543
83MP0003937_abnormal_limbs/digits/tail_de1.07706234
84MP0000767_abnormal_smooth_muscle1.07253937
85MP0003935_abnormal_craniofacial_develop1.06793378
86MP0003646_muscle_fatigue1.06172248
87MP0002109_abnormal_limb_morphology1.05623406
88MP0002088_abnormal_embryonic_growth/wei1.04416564
89MP0000266_abnormal_heart_morphology1.02919807
90MP0002102_abnormal_ear_morphology1.02033784
91MP0002115_abnormal_skeleton_extremities1.01515246
92MP0001879_abnormal_lymphatic_vessel1.00895445
93MP0000751_myopathy1.00049377
94MP0005390_skeleton_phenotype0.99890748
95MP0003315_abnormal_perineum_morphology0.99652811
96MP0001672_abnormal_embryogenesis/_devel0.97204771
97MP0005380_embryogenesis_phenotype0.97204771
98MP0003943_abnormal_hepatobiliary_system0.97068855
99MP0006138_congestive_heart_failure0.96460974
100MP0001175_abnormal_lung_morphology0.95738197
101MP0000377_abnormal_hair_follicle0.92222431
102MP0001730_embryonic_growth_arrest0.91153761
103MP0002932_abnormal_joint_morphology0.90350897
104MP0009053_abnormal_anal_canal0.90310260
105MP0000759_abnormal_skeletal_muscle0.89462594
106MP0004947_skin_inflammation0.88952505
107MP0005076_abnormal_cell_differentiation0.87594588
108MP0001270_distended_abdomen0.87570983
109MP0000762_abnormal_tongue_morphology0.87374136
110MP0001614_abnormal_blood_vessel0.87005865
111MP0004147_increased_porphyrin_level0.86859956
112MP0005408_hypopigmentation0.86831568
113MP0004264_abnormal_extraembryonic_tissu0.86699812
114MP0002113_abnormal_skeleton_development0.86366518
115MP0002925_abnormal_cardiovascular_devel0.85262148
116MP0003119_abnormal_digestive_system0.84805191
117MP0005499_abnormal_olfactory_system0.84632783
118MP0005394_taste/olfaction_phenotype0.84632783
119MP0000747_muscle_weakness0.84139574
120MP0010352_gastrointestinal_tract_polyps0.83597710
121MP0002796_impaired_skin_barrier0.82677341
122MP0005395_other_phenotype0.82473329
123MP0003567_abnormal_fetal_cardiomyocyte0.81437583
124MP0002092_abnormal_eye_morphology0.81138576
125MP0002086_abnormal_extraembryonic_tissu0.80857421
126MP0001851_eye_inflammation0.80364122
127MP0002095_abnormal_skin_pigmentation0.78954036
128MP0000163_abnormal_cartilage_morphology0.78928426
129MP0009379_abnormal_foot_pigmentation0.78762922
130MP0008789_abnormal_olfactory_epithelium0.78412768
131MP0002896_abnormal_bone_mineralization0.78119612
132MP0000516_abnormal_urinary_system0.78045424
133MP0005367_renal/urinary_system_phenotyp0.78045424
134MP0008004_abnormal_stomach_pH0.77809161
135MP0002933_joint_inflammation0.77567591
136MP0002108_abnormal_muscle_morphology0.75865634
137MP0005165_increased_susceptibility_to0.75769928
138MP0000462_abnormal_digestive_system0.75054582
139MP0001661_extended_life_span0.74900996
140MP0000432_abnormal_head_morphology0.73848220
141MP0003941_abnormal_skin_development0.73728269
142MP0002168_other_aberrant_phenotype0.73650405
143MP0002009_preneoplasia0.73112976
144MP0000049_abnormal_middle_ear0.72954486
145MP0008007_abnormal_cellular_replicative0.71804503
146MP0003755_abnormal_palate_morphology0.70491118
147MP0002111_abnormal_tail_morphology0.70438465
148MP0009931_abnormal_skin_appearance0.70114895
149MP0000465_gastrointestinal_hemorrhage0.69177952
150MP0002254_reproductive_system_inflammat0.63939744
151MP0002084_abnormal_developmental_patter0.61754547
152MP0001784_abnormal_fluid_regulation0.61303538
153MP0005409_darkened_coat_color0.59802675
154MP0008932_abnormal_embryonic_tissue0.58473376
155MP0001697_abnormal_embryo_size0.57179281
156MP0000467_abnormal_esophagus_morphology0.53500263
157MP0003077_abnormal_cell_cycle0.51281216
158MP0005501_abnormal_skin_physiology0.49452276
159MP0003453_abnormal_keratinocyte_physiol0.48009907
160MP0002697_abnormal_eye_size0.47916377
161MP0002085_abnormal_embryonic_tissue0.46094154
162MP0002233_abnormal_nose_morphology0.45177024
163MP0005666_abnormal_adipose_tissue0.44204676

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)9.20965475
2Ventricular tachycardia (HP:0004756)8.84459052
3Sudden death (HP:0001699)8.67380271
4Bundle branch block (HP:0011710)7.27056610
5Atrial fibrillation (HP:0005110)7.05323673
6Primary atrial arrhythmia (HP:0001692)6.28397199
7Syncope (HP:0001279)6.12159914
8Supraventricular tachycardia (HP:0004755)6.05674897
9Supraventricular arrhythmia (HP:0005115)5.90423954
10Lipoatrophy (HP:0100578)5.55134845
11Protrusio acetabuli (HP:0003179)5.44475299
12Midline defect of the nose (HP:0004122)5.43779732
13Ventricular arrhythmia (HP:0004308)5.23056098
14Ankle contracture (HP:0006466)5.06715703
15Palpitations (HP:0001962)4.81216490
16Dilated cardiomyopathy (HP:0001644)4.65919601
17Heart block (HP:0012722)4.59471264
18Muscle fiber splitting (HP:0003555)4.50394894
19Abnormal atrioventricular conduction (HP:0005150)4.33779296
20Follicular hyperkeratosis (HP:0007502)4.28208818
21Aortic dissection (HP:0002647)4.18766359
22Hyporeflexia of lower limbs (HP:0002600)4.15284038
23Abnormality of the calf musculature (HP:0001430)4.15216418
24Abnormality of the left ventricular outflow tract (HP:0011103)3.84917534
25Subaortic stenosis (HP:0001682)3.84917534
26Atrioventricular block (HP:0001678)3.82243234
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.79980318
28Short 4th metacarpal (HP:0010044)3.79980318
29Long toe (HP:0010511)3.79072727
30Camptodactyly of toe (HP:0001836)3.74316933
31Aortic aneurysm (HP:0004942)3.70127557
32Premature rupture of membranes (HP:0001788)3.65913580
33Ventricular fibrillation (HP:0001663)3.65805238
34Broad metatarsal (HP:0001783)3.62971517
35Bladder diverticulum (HP:0000015)3.62611566
36Subacute progressive viral hepatitis (HP:0006572)3.52530898
37Spinal rigidity (HP:0003306)3.47752988
38Shawl scrotum (HP:0000049)3.46771114
39Shallow orbits (HP:0000586)3.46670813
40Hypoplastic left heart (HP:0004383)3.27573361
41Left ventricular hypertrophy (HP:0001712)3.25963254
42Asymmetric septal hypertrophy (HP:0001670)3.11386302
43Palmoplantar keratoderma (HP:0000982)3.10827268
44Renovascular hypertension (HP:0100817)3.10476015
45Flexion contracture of toe (HP:0005830)2.97006958
46Joint contractures involving the joints of the feet (HP:0100492)2.97006958
47Bradycardia (HP:0001662)2.94343791
48Pulmonary artery stenosis (HP:0004415)2.93135007
49Cerebral aneurysm (HP:0004944)2.92562013
50Renal duplication (HP:0000075)2.90224319
51Atrophic scars (HP:0001075)2.89895971
52Hyperacusis (HP:0010780)2.84484048
53Type 1 muscle fiber predominance (HP:0003803)2.79426462
54Increased variability in muscle fiber diameter (HP:0003557)2.78552051
55Mitral valve prolapse (HP:0001634)2.77678996
56Thin bony cortex (HP:0002753)2.77068242
57Abnormal EKG (HP:0003115)2.75403047
58Selective tooth agenesis (HP:0001592)2.73493000
59Onycholysis (HP:0001806)2.73132569
60Flat capital femoral epiphysis (HP:0003370)2.71584809
61Prolonged QT interval (HP:0001657)2.69857002
62Abnormality of the 4th metacarpal (HP:0010012)2.61739889
63Fragile skin (HP:0001030)2.60755554
64Skin pits (HP:0100276)2.60273113
65Slender build (HP:0001533)2.59434168
66Soft skin (HP:0000977)2.56365185
67Flat cornea (HP:0007720)2.55891506
68Milia (HP:0001056)2.55358286
69Spinal cord lesions (HP:0100561)2.48649778
70Syringomyelia (HP:0003396)2.48649778
71Abnormality of skeletal muscle fiber size (HP:0012084)2.48356251
72Bowel diverticulosis (HP:0005222)2.46024915
73EMG: myopathic abnormalities (HP:0003458)2.44134846
74Distal lower limb muscle weakness (HP:0009053)2.41168320
75Rectal prolapse (HP:0002035)2.41091262
76Blepharitis (HP:0000498)2.40851698
77Hypoplastic heart (HP:0001961)2.40742537
78Neonatal short-limb short stature (HP:0008921)2.40099106
79Increased connective tissue (HP:0009025)2.39871676
80EMG: neuropathic changes (HP:0003445)2.39194306
81Overriding aorta (HP:0002623)2.38222549
82Double outlet right ventricle (HP:0001719)2.37755416
83Congenital malformation of the right heart (HP:0011723)2.37755416
84Abnormality of dentin (HP:0010299)2.34528008
85Dilatation of the ascending aorta (HP:0005111)2.33760996
86Buphthalmos (HP:0000557)2.33521573
87Missing ribs (HP:0000921)2.28347110
88Hip contracture (HP:0003273)2.27864580
89Pili torti (HP:0003777)2.26127302
90Papillary thyroid carcinoma (HP:0002895)2.25930411
91Arachnodactyly (HP:0001166)2.24984186
92Calf muscle hypertrophy (HP:0008981)2.24545173
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.24152524
94Osteolytic defects of the hand bones (HP:0009699)2.24152524
95Periauricular skin pits (HP:0100277)2.22025043
96Preauricular pit (HP:0004467)2.22025043
97Absent frontal sinuses (HP:0002688)2.20481875
98Abnormality of the salivary glands (HP:0010286)2.18876962
99Mitral regurgitation (HP:0001653)2.18147404
100Vertebral compression fractures (HP:0002953)2.16963096
101Blue sclerae (HP:0000592)2.15193946
102Peritonitis (HP:0002586)2.15011233
103Trigonocephaly (HP:0000243)2.13948669
104Sudden cardiac death (HP:0001645)2.12066243
105Hematochezia (HP:0002573)2.10185655
106Ragged-red muscle fibers (HP:0003200)2.10088431
107Elfin facies (HP:0004428)2.09049094
108Bell-shaped thorax (HP:0001591)2.08806509
109Ectopia lentis (HP:0001083)2.08708937
110Fragile nails (HP:0001808)2.05176451
111Abnormality of the anterior chamber (HP:0000593)2.05141177
112Patent foramen ovale (HP:0001655)2.04743547
113Alopecia of scalp (HP:0002293)2.03995004
114Broad palm (HP:0001169)2.03923904
115Sacral dimple (HP:0000960)2.01519561
116Dislocated radial head (HP:0003083)1.99665071
117Resting tremor (HP:0002322)1.99510563
118Hypoglycemic coma (HP:0001325)1.99348831
119Centrally nucleated skeletal muscle fibers (HP:0003687)1.98941992
120Joint laxity (HP:0001388)1.98670098
121Exercise-induced muscle cramps (HP:0003710)1.98257859
122Aortic regurgitation (HP:0001659)1.97428756
123Biconcave vertebral bodies (HP:0004586)1.94939234
124Neck muscle weakness (HP:0000467)1.94686597
125Elbow flexion contracture (HP:0002987)1.94430484
126Maternal diabetes (HP:0009800)1.94044306
127Wormian bones (HP:0002645)1.91328480
128Anterior segment dysgenesis (HP:0007700)1.90812395
129Patellar dislocation (HP:0002999)1.89764929
130Abnormality of the parietal bone (HP:0002696)1.89596692
131Limb hypertonia (HP:0002509)1.87705629
132Cervical subluxation (HP:0003308)1.87111630
133Bicuspid aortic valve (HP:0001647)1.87048437
134Muscle hypertrophy of the lower extremities (HP:0008968)1.86809932
135Woolly hair (HP:0002224)1.86707575
136Hypotrichosis (HP:0001006)1.83871969
137Abnormality of the radial head (HP:0003995)1.83462287
138Dysmetric saccades (HP:0000641)1.83161992
139Hallux valgus (HP:0001822)1.82190949
140Lymphangioma (HP:0100764)1.81110128
141Transposition of the great arteries (HP:0001669)1.80938743
142Abnormal connection of the cardiac segments (HP:0011545)1.80938743
143Abnormal ventriculo-arterial connection (HP:0011563)1.80938743
144Anteriorly placed anus (HP:0001545)1.80793577
145Protruding ear (HP:0000411)1.80361361
146Broad ribs (HP:0000885)1.79787171
147Abnormality of the diencephalon (HP:0010662)1.79720055
148Limited hip movement (HP:0008800)1.78685897
149Aneurysm (HP:0002617)1.78349965
150Increased nuchal translucency (HP:0010880)1.78333677
151Mesomelia (HP:0003027)1.76727975
152Deviation of the hallux (HP:0010051)1.76435600
153Striae distensae (HP:0001065)1.76209200
154Abnormality of the tricuspid valve (HP:0001702)1.73637547
155Abnormality of the frontal sinuses (HP:0002687)1.73394219
156Disproportionate tall stature (HP:0001519)1.73237207
157Gonadotropin excess (HP:0000837)1.72815466
158Rimmed vacuoles (HP:0003805)1.72150758
159Gonadal dysgenesis (HP:0000133)1.72091731
160Hypoplasia of the iris (HP:0007676)1.71829490
161Broad long bones (HP:0005622)1.70667832
162Proximal tubulopathy (HP:0000114)1.70296683
163Viral hepatitis (HP:0006562)1.70009105
164Micronodular cirrhosis (HP:0001413)1.69702204
165Knee flexion contracture (HP:0006380)1.68938097
166Congestive heart failure (HP:0001635)1.65060529
167Complete atrioventricular canal defect (HP:0001674)1.62294757
168Plantar hyperkeratosis (HP:0007556)1.60979568
169Abnormality of the foot musculature (HP:0001436)1.60844590
170Toxemia of pregnancy (HP:0100603)1.57131695
171Supernumerary spleens (HP:0009799)1.54631175
172Progressive muscle weakness (HP:0003323)1.52999258
173Dry hair (HP:0011359)1.52607912
174Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.52180039
175Prenatal maternal abnormality (HP:0002686)1.51712179
176Mildly elevated creatine phosphokinase (HP:0008180)1.49029193
177Septo-optic dysplasia (HP:0100842)1.44831298
178Hypoplastic pelvis (HP:0008839)1.42991361
179Exercise-induced myalgia (HP:0003738)1.41913232
180Thyroid carcinoma (HP:0002890)1.39858083
181Increased serum pyruvate (HP:0003542)1.38516441
182Neonatal death (HP:0003811)1.38235842
183Aplasia of the musculature (HP:0100854)1.36900740
184Central scotoma (HP:0000603)1.36474302
185Abnormality of chromosome segregation (HP:0002916)1.35745592
186Lip pit (HP:0100267)1.35564213
187Nausea (HP:0002018)1.32940177
188Bicornuate uterus (HP:0000813)1.32707754
189Biliary tract neoplasm (HP:0100574)1.32143939
190Aplasia cutis congenita (HP:0001057)1.31149052
191Atrioventricular canal defect (HP:0006695)1.30310217
192Myokymia (HP:0002411)1.30231523
193Advanced eruption of teeth (HP:0006288)1.29473950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.21199150
2TRIB34.18398607
3STK243.44037192
4PIK3CG3.14653437
5LATS13.05459270
6MYLK3.04148948
7TGFBR13.00611430
8TTN2.64824637
9PKN22.59450850
10EPHA32.53220555
11PDGFRA2.45398237
12STK38L2.41796437
13EEF2K2.40299892
14MAP3K102.24097838
15SIK12.19032713
16DDR22.16517487
17KIT2.11329066
18PBK2.07738010
19MST42.05902201
20PTK61.99520534
21LATS21.97008787
22MAP3K91.96521797
23MAP3K51.90700552
24ERN11.89220853
25TTK1.85628812
26RIPK11.81649799
27PAK41.81231423
28ARAF1.76094715
29TGFBR21.73311291
30PLK41.71071040
31PDK21.68964883
32PDGFRB1.67462788
33PAK21.61950754
34STK31.60638369
35CSF1R1.56731782
36PTK2B1.56265829
37CDK121.48050220
38LMTK21.47905505
39LRRK21.46493863
40TRPM71.44480309
41MUSK1.42451196
42CDC42BPA1.39889597
43FLT31.32239895
44DMPK1.28187282
45JAK31.28030770
46PRKD31.27095996
47CAMK2D1.26617665
48EPHB11.24901030
49MAP4K11.23222409
50GRK71.23214627
51DAPK31.22280338
52ZAP701.16245043
53PRKCE1.14697937
54MET1.13472885
55WNK11.11199513
56MST1R1.10404570
57PIK3CA1.10051486
58PTK21.09107392
59ACVR1B1.08110418
60RPS6KB21.08019105
61TIE11.07355988
62MTOR1.02326353
63NUAK10.97416433
64TYRO30.95351538
65EPHB20.95166093
66CLK10.92804625
67CAMK2A0.92015069
68FGFR10.91138613
69BMPR1B0.90873794
70ICK0.90143819
71PAK30.88907158
72CAMK10.86666178
73ILK0.86316974
74RET0.86131672
75PINK10.85975952
76STK40.85617193
77CDK70.83270206
78RAF10.81555999
79BTK0.81140604
80BMX0.80345852
81MKNK10.77727396
82STK390.77307928
83NEK60.77111305
84EIF2AK30.77087112
85CDK90.76837201
86TBK10.76075235
87ROCK20.75936717
88BRAF0.75576303
89MAP3K60.72657222
90KSR20.70629843
91NEK10.69373180
92PASK0.69121455
93ROCK10.67352465
94FGFR20.65180292
95NLK0.63984194
96NEK90.63459534
97PRKCH0.62528926
98CHUK0.61682810
99PRKAA20.60938046
100PRKCI0.59286112
101CSNK1A1L0.58343739
102MAP2K30.57528281
103MKNK20.54590576
104MAPKAPK30.53671427
105CDK80.53571463
106TESK10.52032835
107FER0.50690050
108NEK20.49301317
109MAP3K130.49040851
110TEC0.48186331
111CDK60.47978624
112MAPK120.47941974
113PRKAA10.47756527
114CAMK1D0.47619172
115CDC70.47362391
116AKT30.47356855
117MAPKAPK50.47091391
118RPS6KA40.46755106
119MATK0.46032537
120PLK10.45904449
121CSNK1G10.44862721
122EPHA20.44471571
123ATM0.44393253
124FGFR30.44364455
125CDK40.44355846
126EPHA40.44193255
127PRKG10.44002860
128ERBB20.43863158
129PRKG20.43473375
130ERBB30.43377379
131PRKACA0.43093027
132CAMK40.42082098
133CSNK1E0.41912255
134TNIK0.41744203
135GSK3A0.40729461
136MAPK10.40713061
137PRKACB0.40546646
138FGFR40.39998015
139PNCK0.39007848
140DYRK1B0.38550530
141IGF1R0.37582393
142PHKG10.37111687
143PHKG20.37111687
144PRKACG0.37107106
145PRKD10.36877604
146MARK30.36875330
147BRD40.36746390
148DYRK30.36632026
149SRPK10.36455380
150LCK0.35721211
151AKT20.35338401
152SRC0.33787844
153RPS6KA10.33044258
154INSR0.32906810
155ATR0.32899831
156AURKB0.32778775
157WEE10.32656797
158CAMK2G0.32275301
159MAPKAPK20.32253947
160CHEK10.32229793
161AURKA0.31618817
162PRKD20.30531073
163MAP2K20.30451524
164MAPK30.29645422
165MAPK100.29448861
166BRSK20.27475865

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.37747891
2ECM-receptor interaction_Homo sapiens_hsa045123.48728140
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.01571430
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.68000827
5Focal adhesion_Homo sapiens_hsa045102.44098474
6Small cell lung cancer_Homo sapiens_hsa052222.34024416
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.33547299
8Basal cell carcinoma_Homo sapiens_hsa052172.16450553
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03936673
10Platelet activation_Homo sapiens_hsa046112.01313117
11Protein digestion and absorption_Homo sapiens_hsa049741.95262312
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91209422
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.91187049
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83095170
15Hedgehog signaling pathway_Homo sapiens_hsa043401.80492241
16Amoebiasis_Homo sapiens_hsa051461.79242611
17Toxoplasmosis_Homo sapiens_hsa051451.72754231
18Proteoglycans in cancer_Homo sapiens_hsa052051.65561919
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60576626
20Circadian rhythm_Homo sapiens_hsa047101.59913403
21Tight junction_Homo sapiens_hsa045301.57098970
22Chronic myeloid leukemia_Homo sapiens_hsa052201.56055106
23TGF-beta signaling pathway_Homo sapiens_hsa043501.51347282
24Propanoate metabolism_Homo sapiens_hsa006401.48259870
25Acute myeloid leukemia_Homo sapiens_hsa052211.47439561
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46344155
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45146089
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.39413019
29Adherens junction_Homo sapiens_hsa045201.38439576
30Hippo signaling pathway_Homo sapiens_hsa043901.35043233
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33248701
32Pancreatic cancer_Homo sapiens_hsa052121.32737915
33Pathways in cancer_Homo sapiens_hsa052001.31181861
34HTLV-I infection_Homo sapiens_hsa051661.30871293
35Colorectal cancer_Homo sapiens_hsa052101.30437151
36Pyruvate metabolism_Homo sapiens_hsa006201.26728546
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22931050
38Viral myocarditis_Homo sapiens_hsa054161.19756359
39Oocyte meiosis_Homo sapiens_hsa041141.19715210
40Osteoclast differentiation_Homo sapiens_hsa043801.18005450
41MicroRNAs in cancer_Homo sapiens_hsa052061.15529255
42N-Glycan biosynthesis_Homo sapiens_hsa005101.14764268
43Prostate cancer_Homo sapiens_hsa052151.10862229
44Endometrial cancer_Homo sapiens_hsa052131.09865410
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09368658
46VEGF signaling pathway_Homo sapiens_hsa043701.08847482
47Basal transcription factors_Homo sapiens_hsa030221.07896762
48Base excision repair_Homo sapiens_hsa034101.07665893
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06316121
50B cell receptor signaling pathway_Homo sapiens_hsa046621.06260628
51Malaria_Homo sapiens_hsa051441.05646626
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05102738
53Wnt signaling pathway_Homo sapiens_hsa043101.04814790
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02056333
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01863102
56Carbon metabolism_Homo sapiens_hsa012001.01020240
57Cell cycle_Homo sapiens_hsa041101.00951957
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00514575
59TNF signaling pathway_Homo sapiens_hsa046681.00464329
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.00315216
61Thyroid cancer_Homo sapiens_hsa052160.98652435
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.97588845
63Rap1 signaling pathway_Homo sapiens_hsa040150.97347143
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.96798391
65Parkinsons disease_Homo sapiens_hsa050120.95514976
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95365142
67Renin secretion_Homo sapiens_hsa049240.93624819
68Mismatch repair_Homo sapiens_hsa034300.90656693
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89553497
70Non-small cell lung cancer_Homo sapiens_hsa052230.89271521
71Leishmaniasis_Homo sapiens_hsa051400.86916725
72mRNA surveillance pathway_Homo sapiens_hsa030150.85983403
73Glioma_Homo sapiens_hsa052140.84938139
74RNA degradation_Homo sapiens_hsa030180.83676722
75Hematopoietic cell lineage_Homo sapiens_hsa046400.82432964
76cAMP signaling pathway_Homo sapiens_hsa040240.81803306
77Viral carcinogenesis_Homo sapiens_hsa052030.81373094
78Gap junction_Homo sapiens_hsa045400.79834903
79Herpes simplex infection_Homo sapiens_hsa051680.79257742
80Fatty acid elongation_Homo sapiens_hsa000620.78043509
81Antigen processing and presentation_Homo sapiens_hsa046120.77620603
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77547911
83Dorso-ventral axis formation_Homo sapiens_hsa043200.76490759
84T cell receptor signaling pathway_Homo sapiens_hsa046600.76403628
85Arginine and proline metabolism_Homo sapiens_hsa003300.75735625
86Hepatitis B_Homo sapiens_hsa051610.74793120
87Prolactin signaling pathway_Homo sapiens_hsa049170.74235648
88Calcium signaling pathway_Homo sapiens_hsa040200.74066994
89Axon guidance_Homo sapiens_hsa043600.73481525
90Ovarian steroidogenesis_Homo sapiens_hsa049130.73089316
91Apoptosis_Homo sapiens_hsa042100.72956543
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70301861
93Shigellosis_Homo sapiens_hsa051310.70072539
94Dilated cardiomyopathy_Homo sapiens_hsa054140.70010980
95* Insulin resistance_Homo sapiens_hsa049310.69024832
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67737249
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.67214580
98Measles_Homo sapiens_hsa051620.66991021
99Renal cell carcinoma_Homo sapiens_hsa052110.66990902
100Notch signaling pathway_Homo sapiens_hsa043300.66727443
101Melanoma_Homo sapiens_hsa052180.66568053
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66502661
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65716430
104Nucleotide excision repair_Homo sapiens_hsa034200.64859253
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64187578
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63918203
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63051792
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62998471
109Fatty acid metabolism_Homo sapiens_hsa012120.62175382
110FoxO signaling pathway_Homo sapiens_hsa040680.62000145
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61373736
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60860467
113Lysine degradation_Homo sapiens_hsa003100.60841042
114Taste transduction_Homo sapiens_hsa047420.60811571
115Biosynthesis of amino acids_Homo sapiens_hsa012300.60174107
116p53 signaling pathway_Homo sapiens_hsa041150.60124080
117Ribosome_Homo sapiens_hsa030100.60036441
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59693203
119Fatty acid degradation_Homo sapiens_hsa000710.59618729
120Oxytocin signaling pathway_Homo sapiens_hsa049210.59611716
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59252238
122mTOR signaling pathway_Homo sapiens_hsa041500.58873251
123Estrogen signaling pathway_Homo sapiens_hsa049150.58528249
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58114855
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58039666
126Melanogenesis_Homo sapiens_hsa049160.57444884
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57284673
128Insulin secretion_Homo sapiens_hsa049110.56418519
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.55876934
130Ras signaling pathway_Homo sapiens_hsa040140.55268807
131Pancreatic secretion_Homo sapiens_hsa049720.54705393
132Huntingtons disease_Homo sapiens_hsa050160.54657204
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54433826
134DNA replication_Homo sapiens_hsa030300.52465820
135Olfactory transduction_Homo sapiens_hsa047400.52049802
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51615788
137RNA transport_Homo sapiens_hsa030130.51446061
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51042356
139Circadian entrainment_Homo sapiens_hsa047130.46837537
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45851388
141Insulin signaling pathway_Homo sapiens_hsa049100.45745183
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42560699
143Arginine biosynthesis_Homo sapiens_hsa002200.42292149
144Alzheimers disease_Homo sapiens_hsa050100.39415076
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39304299
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38471679
147Gastric acid secretion_Homo sapiens_hsa049710.38353672
148Thyroid hormone synthesis_Homo sapiens_hsa049180.38214938
149Oxidative phosphorylation_Homo sapiens_hsa001900.37070842
150Non-homologous end-joining_Homo sapiens_hsa034500.36793885
151Fanconi anemia pathway_Homo sapiens_hsa034600.35103353
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32756469
153Purine metabolism_Homo sapiens_hsa002300.32517972
154Bile secretion_Homo sapiens_hsa049760.32151932
155AMPK signaling pathway_Homo sapiens_hsa041520.30436671
156Homologous recombination_Homo sapiens_hsa034400.29830390
157Galactose metabolism_Homo sapiens_hsa000520.29240479
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27914573
159Glucagon signaling pathway_Homo sapiens_hsa049220.27563117

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