SLC28A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striatum development (GO:0021756)7.41567171
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)7.08583459
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)7.08583459
4positive regulation of gamma-delta T cell activation (GO:0046645)6.80628786
5antigen processing and presentation of endogenous antigen (GO:0019883)6.77638398
6cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.49470997
7behavioral response to nicotine (GO:0035095)5.92880401
8outflow tract septum morphogenesis (GO:0003148)5.79904507
9platelet dense granule organization (GO:0060155)5.72965998
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.36920565
11regulation of gamma-delta T cell differentiation (GO:0045586)5.20263595
12neuronal action potential (GO:0019228)5.12939093
13regulation of B cell receptor signaling pathway (GO:0050855)5.08436431
14regulation of gamma-delta T cell activation (GO:0046643)5.05901362
15thrombin receptor signaling pathway (GO:0070493)4.96780161
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91729529
17serotonin metabolic process (GO:0042428)4.83272499
18glandular epithelial cell development (GO:0002068)4.79390054
19positive thymic T cell selection (GO:0045059)4.59936782
20leukocyte aggregation (GO:0070486)4.57306161
21positive regulation of action potential (GO:0045760)4.56541841
22B cell receptor signaling pathway (GO:0050853)4.42968468
23embryonic digestive tract development (GO:0048566)4.31763384
24primary amino compound metabolic process (GO:1901160)4.25853769
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25470940
26negative regulation of cell killing (GO:0031342)4.25470940
27positive regulation of fatty acid transport (GO:2000193)4.22377767
28negative T cell selection (GO:0043383)4.21864638
29cysteine metabolic process (GO:0006534)4.19978620
30T cell migration (GO:0072678)4.17898936
31negative thymic T cell selection (GO:0045060)4.16412266
32negative regulation of chondrocyte differentiation (GO:0032331)4.10143981
33positive regulation of prostaglandin secretion (GO:0032308)4.07967144
34glomerular filtration (GO:0003094)4.03758271
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.03600059
36cellular response to zinc ion (GO:0071294)4.02155826
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.95086622
38fucose catabolic process (GO:0019317)3.94928360
39L-fucose metabolic process (GO:0042354)3.94928360
40L-fucose catabolic process (GO:0042355)3.94928360
41response to type I interferon (GO:0034340)3.94305223
42negative regulation of leukocyte chemotaxis (GO:0002689)3.91198400
43cellular response to ATP (GO:0071318)3.89362500
44type I interferon signaling pathway (GO:0060337)3.86722635
45cellular response to type I interferon (GO:0071357)3.86722635
46regulation of interferon-beta biosynthetic process (GO:0045357)3.86272880
47positive regulation of icosanoid secretion (GO:0032305)3.84025713
48positive T cell selection (GO:0043368)3.81976019
49proline transport (GO:0015824)3.79924735
50positive regulation of B cell differentiation (GO:0045579)3.79071990
51regulation of B cell differentiation (GO:0045577)3.75714346
52glycine transport (GO:0015816)3.75318915
53regulation of T cell receptor signaling pathway (GO:0050856)3.70676466
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.69362186
55interferon-gamma-mediated signaling pathway (GO:0060333)3.67679362
56indole-containing compound catabolic process (GO:0042436)3.67589030
57indolalkylamine catabolic process (GO:0046218)3.67589030
58tryptophan catabolic process (GO:0006569)3.67589030
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.64972270
60indole-containing compound metabolic process (GO:0042430)3.64051268
61thymic T cell selection (GO:0045061)3.63850566
62regulation of interleukin-12 biosynthetic process (GO:0045075)3.60629385
63quinone biosynthetic process (GO:1901663)3.60618184
64retinoic acid receptor signaling pathway (GO:0048384)3.58826113
65negative regulation of telomere maintenance (GO:0032205)3.57870197
66T cell selection (GO:0045058)3.55179125
67intestinal absorption (GO:0050892)3.54842563
68negative regulation of phagocytosis (GO:0050765)3.54050933
69positive regulation of interferon-alpha production (GO:0032727)3.53039575
70kynurenine metabolic process (GO:0070189)3.52642331
71regulation of systemic arterial blood pressure (GO:0003073)3.51654330
72regulation of guanylate cyclase activity (GO:0031282)3.48601682
73response to interleukin-15 (GO:0070672)3.48552491
74interferon-gamma production (GO:0032609)3.47054793
75renal filtration (GO:0097205)3.46628691
76reflex (GO:0060004)3.46402027
77immunoglobulin mediated immune response (GO:0016064)3.46321377
78leukocyte cell-cell adhesion (GO:0007159)3.43229197
79negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.43106940
80regulation of interferon-alpha production (GO:0032647)3.41000403
81antigen processing and presentation via MHC class Ib (GO:0002475)3.40527772
82respiratory burst (GO:0045730)3.39293277
83mature B cell differentiation (GO:0002335)3.34664531
84alanine transport (GO:0032328)3.33303989
85glomerulus development (GO:0032835)3.32961058
86antigen receptor-mediated signaling pathway (GO:0050851)3.32469910
87Arp2/3 complex-mediated actin nucleation (GO:0034314)3.32338008
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31703149
89positive regulation by organism of defense response of other organism involved in symbiotic interact3.31703149
90modulation by symbiont of host immune response (GO:0052553)3.31703149
91positive regulation by symbiont of host defense response (GO:0052509)3.31703149
92modulation by symbiont of host defense response (GO:0052031)3.31703149
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31703149
94angiotensin maturation (GO:0002003)3.30439161
95regulation of response to interferon-gamma (GO:0060330)3.27997998
96regulation of type I interferon-mediated signaling pathway (GO:0060338)3.27050323
97cardiac muscle cell differentiation (GO:0055007)3.25329223
98regulation of alpha-beta T cell proliferation (GO:0046640)3.25133762
99regulation of T cell tolerance induction (GO:0002664)3.22358236
100regulation of prostaglandin secretion (GO:0032306)3.22003303
101mast cell activation (GO:0045576)3.21788460
102regulation of cGMP biosynthetic process (GO:0030826)3.21117510
103T cell costimulation (GO:0031295)3.19935130
104indolalkylamine metabolic process (GO:0006586)3.18261493
105columnar/cuboidal epithelial cell development (GO:0002066)3.17594505
106regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.17020462
107cellular response to interleukin-15 (GO:0071350)3.16555238
108lymphocyte costimulation (GO:0031294)3.14493415
109regulation of action potential (GO:0098900)3.13506938
110receptor guanylyl cyclase signaling pathway (GO:0007168)3.12116136
111protein import into peroxisome matrix (GO:0016558)3.12044999
112regulation of posttranscriptional gene silencing (GO:0060147)3.11407916
113regulation of gene silencing by miRNA (GO:0060964)3.11407916
114regulation of gene silencing by RNA (GO:0060966)3.11407916
115defense response to protozoan (GO:0042832)3.09622603
116positive regulation of antigen processing and presentation (GO:0002579)3.09618779
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09484638
118NIK/NF-kappaB signaling (GO:0038061)3.08828719
119somite development (GO:0061053)3.08623869
120negative regulation of cartilage development (GO:0061037)3.07440061
121cellular extravasation (GO:0045123)3.06277628
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06252370
123response to protozoan (GO:0001562)3.04377379
124neutrophil activation involved in immune response (GO:0002283)3.04257461
125negative regulation of T cell receptor signaling pathway (GO:0050860)3.03751881
126tryptophan metabolic process (GO:0006568)3.02121492
127behavioral response to ethanol (GO:0048149)3.01938670
128sulfation (GO:0051923)3.00673302
129negative regulation of heart rate (GO:0010459)3.00231177
130T cell receptor signaling pathway (GO:0050852)3.00056914
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.99292618
132positive regulation of protein kinase C signaling (GO:0090037)2.96456276
133ureteric bud development (GO:0001657)2.94627992
134exogenous drug catabolic process (GO:0042738)2.93861506
135T cell homeostasis (GO:0043029)2.93182524
136kidney morphogenesis (GO:0060993)2.92616763
137intestinal cholesterol absorption (GO:0030299)2.92173973
138myeloid dendritic cell activation (GO:0001773)2.91324500
139epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91248575
140nephron epithelium morphogenesis (GO:0072088)2.91015827
141nephron tubule morphogenesis (GO:0072078)2.91015827
142regulation of hippo signaling (GO:0035330)2.90877730
143neutrophil mediated immunity (GO:0002446)2.90622641
144cellular response to interferon-beta (GO:0035458)2.90317409
145positive regulation of guanylate cyclase activity (GO:0031284)2.89917142
146regulation of cGMP metabolic process (GO:0030823)2.89561002
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88032067
148action potential (GO:0001508)2.87281465
149mature B cell differentiation involved in immune response (GO:0002313)2.87113710
150central nervous system myelination (GO:0022010)2.86792668
151axon ensheathment in central nervous system (GO:0032291)2.86792668
152postsynaptic membrane organization (GO:0001941)2.86792261
153positive regulation of interleukin-2 production (GO:0032743)2.86636932
154ubiquinone biosynthetic process (GO:0006744)2.86609786
155lymphocyte homeostasis (GO:0002260)2.84805864
156cGMP-mediated signaling (GO:0019934)2.84706170
157positive regulation of lamellipodium assembly (GO:0010592)2.84252377
158positive regulation of cGMP biosynthetic process (GO:0030828)2.83727837
159regulation of icosanoid secretion (GO:0032303)2.82836976
160regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.82442468
161startle response (GO:0001964)2.80264378
162gamma-aminobutyric acid transport (GO:0015812)2.78695137
163regulation of myelination (GO:0031641)2.78559602
164tolerance induction (GO:0002507)2.78417985
165negative regulation of interleukin-12 production (GO:0032695)2.78103021
166drug catabolic process (GO:0042737)2.77701646
167epithelial cilium movement (GO:0003351)2.77386372
168regulation of isotype switching to IgG isotypes (GO:0048302)2.76993654
169neuronal stem cell maintenance (GO:0097150)2.76592909
170positive regulation of organic acid transport (GO:0032892)2.76399412
171hepatocyte apoptotic process (GO:0097284)2.75627083
172macrophage activation involved in immune response (GO:0002281)2.75150711
173positive regulation of interferon-beta production (GO:0032728)2.73936675
174B cell homeostasis (GO:0001782)2.73831603
175neutrophil activation (GO:0042119)2.73322343
176B cell mediated immunity (GO:0019724)2.72708718
177cellular response to interferon-gamma (GO:0071346)2.72193052
178immune response-activating cell surface receptor signaling pathway (GO:0002429)2.71562345
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.71012646
180negative regulation of Rho protein signal transduction (GO:0035024)2.69863769
181ubiquinone metabolic process (GO:0006743)2.69599734
182activated T cell proliferation (GO:0050798)2.69036168
183regulation of regulatory T cell differentiation (GO:0045589)2.68029596
184epoxygenase P450 pathway (GO:0019373)2.67948525
185positive regulation of isotype switching (GO:0045830)2.67684471
186myeloid cell activation involved in immune response (GO:0002275)2.67308174
187response to fungus (GO:0009620)2.67278563
188T cell proliferation (GO:0042098)2.67192492
189regulation of systemic arterial blood pressure by hormone (GO:0001990)2.66811973
190regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.66811973
191endocrine process (GO:0050886)2.66811973
192germinal center formation (GO:0002467)2.66704711
193neuron fate determination (GO:0048664)2.65673981
194positive regulation of triglyceride biosynthetic process (GO:0010867)2.65205329
195regulation of antigen processing and presentation (GO:0002577)2.64659355
196regulation of tolerance induction (GO:0002643)2.63870357
197negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63749863
198negative regulation of translation, ncRNA-mediated (GO:0040033)2.63749863
199regulation of translation, ncRNA-mediated (GO:0045974)2.63749863
200mesonephric tubule development (GO:0072164)2.62434073

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.72218890
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.55642161
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.69966432
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30857234
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.07467667
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.98249288
7ZNF274_21170338_ChIP-Seq_K562_Hela3.80889226
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74727248
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.60511426
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54906434
11EZH2_22144423_ChIP-Seq_EOC_Human3.53592884
12VDR_22108803_ChIP-Seq_LS180_Human3.24938855
13E2F7_22180533_ChIP-Seq_HELA_Human3.17945786
14GBX2_23144817_ChIP-Seq_PC3_Human3.01254059
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.00574546
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.98190538
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91812919
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.86553762
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82919730
20MYC_22102868_ChIP-Seq_BL_Human2.78798293
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74619706
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71472439
23VDR_21846776_ChIP-Seq_THP-1_Human2.70260576
24MYB_26560356_Chip-Seq_TH2_Human2.67134065
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64745014
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61027849
27MAF_26560356_Chip-Seq_TH1_Human2.51623012
28RUNX_20019798_ChIP-Seq_JUKART_Human2.48984451
29GATA1_22025678_ChIP-Seq_K562_Human2.44582412
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.42464005
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32755304
32MYB_26560356_Chip-Seq_TH1_Human2.31607673
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31460195
34SPI1_23547873_ChIP-Seq_NB4_Human2.29641795
35UTX_26944678_Chip-Seq_JUKART_Human2.27629483
36SCL_19346495_ChIP-Seq_HPC-7_Human2.26126676
37IRF1_19129219_ChIP-ChIP_H3396_Human2.19239726
38BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11384530
39VDR_24763502_ChIP-Seq_THP-1_Human2.09591681
40PIAS1_25552417_ChIP-Seq_VCAP_Human2.08852023
41RUNX1_22412390_ChIP-Seq_EML_Mouse2.06642540
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01412616
43CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00962679
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98641099
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96408027
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.95782173
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95607441
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94881764
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92584838
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92145206
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86024342
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.81932281
53SPI1_23127762_ChIP-Seq_K562_Human1.74441739
54P300_19829295_ChIP-Seq_ESCs_Human1.73441957
55TCF7_22412390_ChIP-Seq_EML_Mouse1.71653904
56BCAT_22108803_ChIP-Seq_LS180_Human1.70560824
57TAF15_26573619_Chip-Seq_HEK293_Human1.69234920
58ER_23166858_ChIP-Seq_MCF-7_Human1.68140577
59FUS_26573619_Chip-Seq_HEK293_Human1.67722273
60GATA3_27048872_Chip-Seq_THYMUS_Human1.66115289
61EWS_26573619_Chip-Seq_HEK293_Human1.66097819
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65451121
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.59181204
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58594824
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.58229351
66MAF_26560356_Chip-Seq_TH2_Human1.57790633
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.57076815
68DROSHA_22980978_ChIP-Seq_HELA_Human1.56855441
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56533792
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.55898182
71AR_25329375_ChIP-Seq_VCAP_Human1.55184810
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50359269
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48565678
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47755612
75PU_27001747_Chip-Seq_BMDM_Mouse1.47358518
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46426494
77REST_21632747_ChIP-Seq_MESCs_Mouse1.45710541
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45078178
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44988679
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.44787955
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.44606937
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43916737
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43682671
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43395583
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41632987
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40348759
87TCF4_22108803_ChIP-Seq_LS180_Human1.39299154
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38041588
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36746650
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.36687421
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36625728
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36143175
93STAT3_23295773_ChIP-Seq_U87_Human1.34724642
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.34334477
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33280581
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32872824
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.32610928
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31945305
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31369889
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29485671
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29219221
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29029214
103CIITA_25753668_ChIP-Seq_RAJI_Human1.27360679
104KDM2B_26808549_Chip-Seq_DND41_Human1.27263493
105JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26733970
106GATA3_26560356_Chip-Seq_TH2_Human1.26509618
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.24573547
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24573547
109CDX2_20551321_ChIP-Seq_CACO-2_Human1.23946828
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23905690
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23235826
112MYC_18940864_ChIP-ChIP_HL60_Human1.22770626
113* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22560685
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.20206618
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19434675
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19409330
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.19215975
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17842232
119JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17304357
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.16650963
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.16422821
122KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15991031
123AR_21572438_ChIP-Seq_LNCaP_Human1.15939983
124SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15813565
125EZH2_27294783_Chip-Seq_ESCs_Mouse1.15390252
126TP53_16413492_ChIP-PET_HCT116_Human1.15232129
127NCOR_22424771_ChIP-Seq_293T_Human1.15158561
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14943698
129* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14887389
130EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14768311
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14708446
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14323708
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13448293
134TP53_22573176_ChIP-Seq_HFKS_Human1.13420634
135ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13325755
136TCF4_23295773_ChIP-Seq_U87_Human1.13254104
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12435148
138STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11956622
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11945931
140IGF1R_20145208_ChIP-Seq_DFB_Human1.11712910
141SMAD4_21799915_ChIP-Seq_A2780_Human1.10976855
142TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10753353
143CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10604218
144SMAD4_21741376_ChIP-Seq_EPCs_Human1.09908501
145PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09694666
146AHR_22903824_ChIP-Seq_MCF-7_Human1.09285827
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08892801
148PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08857263
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08627244
150RNF2_27304074_Chip-Seq_NSC_Mouse1.07993683
151SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07701616
152HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07658480
153GATA1_19941827_ChIP-Seq_MEL_Mouse1.07475468
154EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06930760
155RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06930760
156GATA4_25053715_ChIP-Seq_YYC3_Human1.05940547
157MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05872840
158AR_20517297_ChIP-Seq_VCAP_Human1.05715932
159NANOG_19829295_ChIP-Seq_ESCs_Human1.04462222
160SOX2_19829295_ChIP-Seq_ESCs_Human1.04462222
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02964418
162GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02845054
163HOXB7_26014856_ChIP-Seq_BT474_Human1.02317355
164ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01185402
165SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01056463
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00792004
167EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00694506
168SMAD3_21741376_ChIP-Seq_ESCs_Human1.00305039
169RXR_22108803_ChIP-Seq_LS180_Human1.00107927
170PRDM14_20953172_ChIP-Seq_ESCs_Human0.99640050
171RUNX2_22187159_ChIP-Seq_PCA_Human0.99476094
172SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97469925
173RNF2_27304074_Chip-Seq_ESCs_Mouse0.96998770
174ERA_21632823_ChIP-Seq_H3396_Human0.96986167
175POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96709390
176TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96709390
177NANOG_20526341_ChIP-Seq_ESCs_Human0.96676289
178NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92319581
179GATA2_19941826_ChIP-Seq_K562_Human0.88111496
180NCOR1_26117541_ChIP-Seq_K562_Human0.83723310
181E2F4_17652178_ChIP-ChIP_JURKAT_Human0.83397530
182RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82677256
183PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81885853
184THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80234701
185TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79457485
186GATA2_21666600_ChIP-Seq_HMVEC_Human0.79438959
187VDR_24787735_ChIP-Seq_THP-1_Human0.78383138
188FOXP3_21729870_ChIP-Seq_TREG_Human0.77106399
189PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76025426
190GATA1_19941826_ChIP-Seq_K562_Human0.75016980
191* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73374209
192VDR_23849224_ChIP-Seq_CD4+_Human0.72561074
193LXR_22292898_ChIP-Seq_THP-1_Human0.72225386
194P300_27268052_Chip-Seq_Bcells_Human0.72097887
195RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71183103
196* SPI1_20517297_ChIP-Seq_HL60_Human0.71175723
197KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.70771911

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology7.33544224
2MP0005248_abnormal_Harderian_gland5.11634116
3MP0001835_abnormal_antigen_presentation3.99500283
4MP0003136_yellow_coat_color3.65878752
5MP0003880_abnormal_central_pattern3.25460640
6MP0001800_abnormal_humoral_immune3.23555682
7MP0005671_abnormal_response_to3.22833769
8MP0005387_immune_system_phenotype3.21238863
9MP0001790_abnormal_immune_system3.21238863
10MP0000685_abnormal_immune_system3.19350388
11MP0003763_abnormal_thymus_physiology3.14757664
12MP0009785_altered_susceptibility_to3.04199858
13MP0003303_peritoneal_inflammation2.93054317
14MP0009379_abnormal_foot_pigmentation2.92342397
15MP0005000_abnormal_immune_tolerance2.85798034
16MP0003436_decreased_susceptibility_to2.78527349
17MP0002452_abnormal_antigen_presenting2.78490071
18MP0004885_abnormal_endolymph2.76159514
19MP0005025_abnormal_response_to2.75141432
20MP0002420_abnormal_adaptive_immunity2.70604268
21MP0001819_abnormal_immune_cell2.67463157
22MP0002249_abnormal_larynx_morphology2.67017184
23MP0002396_abnormal_hematopoietic_system2.66820935
24MP0002723_abnormal_immune_serum2.63280489
25MP0003724_increased_susceptibility_to2.59737148
26MP0002419_abnormal_innate_immunity2.51131519
27MP0002282_abnormal_trachea_morphology2.50364978
28MP0002398_abnormal_bone_marrow2.42106131
29MP0002166_altered_tumor_susceptibility2.34243091
30MP0002148_abnormal_hypersensitivity_rea2.26391796
31MP0003300_gastrointestinal_ulcer2.23371580
32MP0000716_abnormal_immune_system2.22391501
33MP0003183_abnormal_peptide_metabolism2.20020732
34MP0010155_abnormal_intestine_physiology2.16251198
35MP0003283_abnormal_digestive_organ2.11638525
36MP0005365_abnormal_bile_salt2.07939385
37MP0002405_respiratory_system_inflammati2.03682403
38MP0005464_abnormal_platelet_physiology2.03554723
39MP0000534_abnormal_ureter_morphology2.03356490
40MP0000613_abnormal_salivary_gland2.01659052
41MP0009333_abnormal_splenocyte_physiolog2.01605365
42MP0000689_abnormal_spleen_morphology2.01511332
43MP0004947_skin_inflammation1.98229748
44MP0003011_delayed_dark_adaptation1.96481155
45MP0002876_abnormal_thyroid_physiology1.95846700
46MP0005085_abnormal_gallbladder_physiolo1.91629876
47MP0002722_abnormal_immune_system1.91349817
48MP0001873_stomach_inflammation1.89716813
49MP0002429_abnormal_blood_cell1.85955021
50MP0003195_calcinosis1.85367288
51MP0003866_abnormal_defecation1.83132199
52MP0001845_abnormal_inflammatory_respons1.80907735
53MP0005171_absent_coat_pigmentation1.76622900
54MP0002006_tumorigenesis1.74864719
55MP0001853_heart_inflammation1.72398607
56MP0004742_abnormal_vestibular_system1.69927710
57MP0001485_abnormal_pinna_reflex1.65399236
58MP0006082_CNS_inflammation1.65014657
59MP0001984_abnormal_olfaction1.62950112
60MP0000703_abnormal_thymus_morphology1.62185492
61MP0002653_abnormal_ependyma_morphology1.61708208
62MP0001533_abnormal_skeleton_physiology1.59044035
63MP0004808_abnormal_hematopoietic_stem1.57370357
64MP0004510_myositis1.56914563
65MP0005083_abnormal_biliary_tract1.54043791
66MP0005360_urolithiasis1.51034402
67MP0001545_abnormal_hematopoietic_system1.49128779
68MP0005397_hematopoietic_system_phenotyp1.49128779
69MP0002102_abnormal_ear_morphology1.48176513
70MP0002932_abnormal_joint_morphology1.44536280
71MP0001501_abnormal_sleep_pattern1.43167091
72MP0005551_abnormal_eye_electrophysiolog1.42531418
73MP0001188_hyperpigmentation1.39640487
74MP0009278_abnormal_bone_marrow1.38478324
75MP0008469_abnormal_protein_level1.37529127
76MP0008875_abnormal_xenobiotic_pharmacok1.36851275
77MP0000230_abnormal_systemic_arterial1.35736092
78MP0009745_abnormal_behavioral_response1.34385015
79MP0000490_abnormal_crypts_of1.32031335
80MP0005058_abnormal_lysosome_morphology1.31574595
81MP0000858_altered_metastatic_potential1.31192683
82MP0005084_abnormal_gallbladder_morpholo1.30725147
83MP0001664_abnormal_digestion1.30723284
84MP0002933_joint_inflammation1.29963365
85MP0004019_abnormal_vitamin_homeostasis1.29720381
86MP0003448_altered_tumor_morphology1.28826066
87MP0005174_abnormal_tail_pigmentation1.28075582
88MP0010329_abnormal_lipoprotein_level1.27909328
89MP0001968_abnormal_touch/_nociception1.25842230
90MP0005197_abnormal_uvea_morphology1.24799584
91MP0000465_gastrointestinal_hemorrhage1.21845800
92MP0005595_abnormal_vascular_smooth1.21626770
93MP0008872_abnormal_physiological_respon1.20354652
94MP0000427_abnormal_hair_cycle1.19887089
95MP0009840_abnormal_foam_cell1.19191182
96MP0000778_abnormal_nervous_system1.18836107
97MP0002909_abnormal_adrenal_gland1.17667870
98MP0002736_abnormal_nociception_after1.17228056
99MP0003172_abnormal_lysosome_physiology1.16198703
100MP0004133_heterotaxia1.15038936
101MP0003718_maternal_effect1.13595954
102MP0010352_gastrointestinal_tract_polyps1.13276869
103MP0004142_abnormal_muscle_tone1.13238673
104MP0002751_abnormal_autonomic_nervous1.11961148
105MP0002272_abnormal_nervous_system1.11956423
106MP0000538_abnormal_urinary_bladder1.11949756
107MP0000343_altered_response_to1.11408141
108MP0005332_abnormal_amino_acid1.10750774
109MP0001986_abnormal_taste_sensitivity1.10116947
110MP0003191_abnormal_cellular_cholesterol1.03052003
111MP0004043_abnormal_pH_regulation1.01553064
112MP0003329_amyloid_beta_deposits1.01305029
113MP0005448_abnormal_energy_balance1.00892698
114MP0005310_abnormal_salivary_gland1.00650989
115MP0002064_seizures1.00436750
116MP0003806_abnormal_nucleotide_metabolis0.94274071
117MP0003635_abnormal_synaptic_transmissio0.94114274
118MP0001486_abnormal_startle_reflex0.93792358
119MP0002638_abnormal_pupillary_reflex0.93233002
120MP0002019_abnormal_tumor_incidence0.92187864
121MP0002063_abnormal_learning/memory/cond0.91992577
122MP0001666_abnormal_nutrient_absorption0.91984007
123MP0002067_abnormal_sensory_capabilities0.90983070
124MP0000026_abnormal_inner_ear0.90763857
125MP0005253_abnormal_eye_physiology0.90457757
126MP0003959_abnormal_lean_body0.89724162
127MP0001286_abnormal_eye_development0.88714340
128MP0003828_pulmonary_edema0.88496058
129MP0002572_abnormal_emotion/affect_behav0.87828922
130MP0001663_abnormal_digestive_system0.87653139
131MP0003632_abnormal_nervous_system0.87530723
132MP0006054_spinal_hemorrhage0.86349945
133MP0010307_abnormal_tumor_latency0.86297281
134MP0009764_decreased_sensitivity_to0.85918869
135MP0006276_abnormal_autonomic_nervous0.85567517
136MP0009763_increased_sensitivity_to0.85427440
137MP0003693_abnormal_embryo_hatching0.85296092
138MP0002233_abnormal_nose_morphology0.84463189
139MP0004215_abnormal_myocardial_fiber0.83892915
140MP0000015_abnormal_ear_pigmentation0.83756915
141MP0008775_abnormal_heart_ventricle0.83723648
142MP0000604_amyloidosis0.83245571
143MP0002277_abnormal_respiratory_mucosa0.82805353
144MP0001851_eye_inflammation0.82641513
145MP0001970_abnormal_pain_threshold0.82553520
146MP0005023_abnormal_wound_healing0.82425401
147MP0002733_abnormal_thermal_nociception0.81903552
148MP0000249_abnormal_blood_vessel0.81819210
149MP0005195_abnormal_posterior_eye0.81580620
150MP0002234_abnormal_pharynx_morphology0.80015275
151MP0004145_abnormal_muscle_electrophysio0.78377753
152MP0000647_abnormal_sebaceous_gland0.77062656
153MP0009046_muscle_twitch0.76892403
154MP0002734_abnormal_mechanical_nocicepti0.76087257
155MP0002139_abnormal_hepatobiliary_system0.76032216
156MP0000383_abnormal_hair_follicle0.75605292
157MP0000609_abnormal_liver_physiology0.74647809
158MP0003656_abnormal_erythrocyte_physiolo0.74543895
159MP0003646_muscle_fatigue0.74028551
160MP0002998_abnormal_bone_remodeling0.74021427
161MP0008877_abnormal_DNA_methylation0.73033661
162MP0005166_decreased_susceptibility_to0.72352856
163MP0002557_abnormal_social/conspecific_i0.72172557
164MP0005381_digestive/alimentary_phenotyp0.70908375
165MP0001324_abnormal_eye_pigmentation0.69810948
166MP0002752_abnormal_somatic_nervous0.69684164
167MP0005508_abnormal_skeleton_morphology0.69405820
168MP0006072_abnormal_retinal_apoptosis0.69316752
169MP0010386_abnormal_urinary_bladder0.69262958
170MP0000049_abnormal_middle_ear0.67850596
171MP0002136_abnormal_kidney_physiology0.67543655
172MP0003566_abnormal_cell_adhesion0.66393057
173MP0003045_fibrosis0.64934187
174MP0003075_altered_response_to0.64291588
175MP0005075_abnormal_melanosome_morpholog0.64254723
176MP0005076_abnormal_cell_differentiation0.63078272
177MP0003221_abnormal_cardiomyocyte_apopto0.62062429
178MP0000477_abnormal_intestine_morphology0.59907028
179MP0000569_abnormal_digit_pigmentation0.59005117
180MP0002095_abnormal_skin_pigmentation0.58075735
181MP0008057_abnormal_DNA_replication0.57152407
182MP0003077_abnormal_cell_cycle0.55009481
183MP0005584_abnormal_enzyme/coenzyme_acti0.53106226
184MP0003091_abnormal_cell_migration0.52813904
185MP0000598_abnormal_liver_morphology0.52591254
186MP0003950_abnormal_plasma_membrane0.52190029
187MP0009643_abnormal_urine_homeostasis0.51811918
188MP0005390_skeleton_phenotype0.51192790
189MP0008873_increased_physiological_sensi0.50084029
190MP0009765_abnormal_xenobiotic_induced0.49267167
191MP0004147_increased_porphyrin_level0.49135140

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)8.55372790
2Annular pancreas (HP:0001734)7.52704319
3Recurrent abscess formation (HP:0002722)5.16582476
4Anophthalmia (HP:0000528)5.13012731
5Bicornuate uterus (HP:0000813)5.11343925
6Recurrent viral infections (HP:0004429)4.95910234
7Autoimmune thrombocytopenia (HP:0001973)4.80941762
8Eczematoid dermatitis (HP:0000976)4.51823154
9Recurrent bronchitis (HP:0002837)4.51543072
10Hydroxyprolinuria (HP:0003080)4.46458508
11Abnormality of proline metabolism (HP:0010907)4.46458508
12Chronic otitis media (HP:0000389)4.41110370
13Recurrent bacterial skin infections (HP:0005406)4.40259260
14Recurrent fungal infections (HP:0002841)4.32961506
15Congenital sensorineural hearing impairment (HP:0008527)4.32536610
16Elevated erythrocyte sedimentation rate (HP:0003565)4.31319840
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.27829640
18Pancreatic cysts (HP:0001737)4.22248592
19Abnormality of B cell number (HP:0010975)4.18850311
20B lymphocytopenia (HP:0010976)4.18850311
21IgM deficiency (HP:0002850)4.01974589
22T lymphocytopenia (HP:0005403)3.99965712
23Stomatitis (HP:0010280)3.96852319
24Myositis (HP:0100614)3.93700938
25Abnormality of T cell number (HP:0011839)3.87569317
26Panhypogammaglobulinemia (HP:0003139)3.86988182
27Eosinophilia (HP:0001880)3.76312801
28Agammaglobulinemia (HP:0004432)3.74893049
29Abnormal lung lobation (HP:0002101)3.67747573
30Severe combined immunodeficiency (HP:0004430)3.64972882
31Abnormality of T cells (HP:0002843)3.64553942
32Pustule (HP:0200039)3.61871722
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.60370089
34Thyroiditis (HP:0100646)3.58066739
35Hyperglycinuria (HP:0003108)3.55380973
36Lymphopenia (HP:0001888)3.55100652
37Meningitis (HP:0001287)3.49230208
38Nasal polyposis (HP:0100582)3.49107912
39Abnormality of midbrain morphology (HP:0002418)3.45776430
40Molar tooth sign on MRI (HP:0002419)3.45776430
41Gastrointestinal stroma tumor (HP:0100723)3.45261763
42Autoimmune hemolytic anemia (HP:0001890)3.45005439
43Combined immunodeficiency (HP:0005387)3.43300481
44Type II lissencephaly (HP:0007260)3.43218747
45Abnormality of cells of the lymphoid lineage (HP:0012140)3.43003300
46Thrombocytosis (HP:0001894)3.40481551
47Mediastinal lymphadenopathy (HP:0100721)3.38142427
48Vasculitis (HP:0002633)3.37571582
49Cellulitis (HP:0100658)3.34838824
50Increased IgE level (HP:0003212)3.33130828
51Tubular atrophy (HP:0000092)3.32691130
52Granulocytopenia (HP:0001913)3.31304871
53Abnormality of T cell physiology (HP:0011840)3.27978016
54Abnormality of eosinophils (HP:0001879)3.27178756
55Epidermoid cyst (HP:0200040)3.25968335
56Inflammation of the large intestine (HP:0002037)3.25173580
57True hermaphroditism (HP:0010459)3.23286879
58Chronic diarrhea (HP:0002028)3.23214522
59Large for gestational age (HP:0001520)3.22801108
60Confusion (HP:0001289)3.22282128
61Recurrent skin infections (HP:0001581)3.21248801
62Congenital stationary night blindness (HP:0007642)3.19609279
63Obstructive lung disease (HP:0006536)3.19384248
64Chronic obstructive pulmonary disease (HP:0006510)3.19384248
65Pancreatic fibrosis (HP:0100732)3.18739929
66Gastrointestinal inflammation (HP:0004386)3.16329319
67Colitis (HP:0002583)3.14001037
68Abnormality of the nasal mucosa (HP:0000433)3.13494133
69Recurrent cutaneous fungal infections (HP:0011370)3.13183988
70Chronic mucocutaneous candidiasis (HP:0002728)3.13183988
71Abnormality of the renal cortex (HP:0011035)3.11637312
72Gingivitis (HP:0000230)3.04690172
73Leukocytosis (HP:0001974)3.04467381
74Decreased circulating renin level (HP:0003351)3.02915117
75Abnormality of macrophages (HP:0004311)2.99871256
76Periodontitis (HP:0000704)2.93213150
77Nephronophthisis (HP:0000090)2.92898395
78Recurrent gram-negative bacterial infections (HP:0005420)2.85889440
79Metabolic alkalosis (HP:0200114)2.84517735
80Abnormality of the renal medulla (HP:0100957)2.84100795
81Abnormality of alanine metabolism (HP:0010916)2.82958411
82Hyperalaninemia (HP:0003348)2.82958411
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82958411
84IgG deficiency (HP:0004315)2.82044135
85Recurrent sinusitis (HP:0011108)2.81441245
86Duodenal stenosis (HP:0100867)2.79550763
87Small intestinal stenosis (HP:0012848)2.79550763
88IgA deficiency (HP:0002720)2.75448247
89Abnormality of the fingertips (HP:0001211)2.74656836
90Inability to walk (HP:0002540)2.72617008
91Broad nasal tip (HP:0000455)2.67195368
92Chronic sinusitis (HP:0011109)2.65469884
93Interstitial pulmonary disease (HP:0006530)2.64716589
94Abnormality of serine family amino acid metabolism (HP:0010894)2.63878936
95Abnormality of glycine metabolism (HP:0010895)2.63878936
96Orchitis (HP:0100796)2.63635719
97Encephalitis (HP:0002383)2.62794381
98Stomach cancer (HP:0012126)2.62593593
99Verrucae (HP:0200043)2.62312407
100Papilloma (HP:0012740)2.62312407
101Emphysema (HP:0002097)2.54293229
102Hypoplasia of the thymus (HP:0000778)2.50373161
103Pulmonary infiltrates (HP:0002113)2.50367911
104Hyperventilation (HP:0002883)2.49907742
105Spontaneous hematomas (HP:0007420)2.49866420
106Hypergammaglobulinemia (HP:0010702)2.48058512
107Lymphoma (HP:0002665)2.43072429
108Congenital, generalized hypertrichosis (HP:0004540)2.41780169
109Chest pain (HP:0100749)2.40645501
110Bronchitis (HP:0012387)2.40500590
111Osteomyelitis (HP:0002754)2.40332826
112Restrictive lung disease (HP:0002091)2.39441437
113Retrobulbar optic neuritis (HP:0100654)2.39396174
114Optic neuritis (HP:0100653)2.39396174
115Abnormal platelet volume (HP:0011876)2.37874314
116Sepsis (HP:0100806)2.36887328
117Attenuation of retinal blood vessels (HP:0007843)2.35538790
118Abnormal drinking behavior (HP:0030082)2.35520921
119Polydipsia (HP:0001959)2.35520921
120Abnormality of the prostate (HP:0008775)2.35469892
121Cystic liver disease (HP:0006706)2.34278257
122Skin ulcer (HP:0200042)2.29981960
123Prolonged bleeding time (HP:0003010)2.29570228
124Xanthomatosis (HP:0000991)2.28940171
125Abnormality of the duodenum (HP:0002246)2.28896904
126Tubulointerstitial fibrosis (HP:0005576)2.25370223
127Petechiae (HP:0000967)2.24409355
128Hemoptysis (HP:0002105)2.21876174
129Alkalosis (HP:0001948)2.18801356
130Medial flaring of the eyebrow (HP:0010747)2.18573235
131Furrowed tongue (HP:0000221)2.18244288
132Progressive inability to walk (HP:0002505)2.17279535
133Dynein arm defect of respiratory motile cilia (HP:0012255)2.16438211
134Absent/shortened dynein arms (HP:0200106)2.16438211
135Abnormality of the vitamin B12 metabolism (HP:0004341)2.15118373
136Polyuria (HP:0000103)2.14401649
137Birth length less than 3rd percentile (HP:0003561)2.12537993
138Progressive cerebellar ataxia (HP:0002073)2.11619898
139Abnormal urine output (HP:0012590)2.11589639
140Abnormality of vitamin B metabolism (HP:0004340)2.10846874
141Recurrent pneumonia (HP:0006532)2.07378310
142Recurrent lower respiratory tract infections (HP:0002783)2.07038574
143Anterior segment dysgenesis (HP:0007700)2.06645691
144Polyphagia (HP:0002591)2.06055532
145Poikiloderma (HP:0001029)2.05967903
146Hemiparesis (HP:0001269)2.05201703
147Potter facies (HP:0002009)2.04961312
148Facial shape deformation (HP:0011334)2.04961312
149Gastrointestinal infarctions (HP:0005244)2.04906844
150Epistaxis (HP:0000421)2.01966186
151Lissencephaly (HP:0001339)2.01829172
152Arterial thrombosis (HP:0004420)2.01716978
153Optic nerve hypoplasia (HP:0000609)1.98603015
154Increased mean platelet volume (HP:0011877)1.97273983
155Abnormal respiratory epithelium morphology (HP:0012253)1.97212042
156Abnormal respiratory motile cilium morphology (HP:0005938)1.97212042
157Abnormality of renin-angiotensin system (HP:0000847)1.97190100
158Impaired platelet aggregation (HP:0003540)1.97129451
159Abnormal platelet function (HP:0011869)1.97129451
160Bilateral microphthalmos (HP:0007633)1.96389318
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96106523
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95572286
163Hypoproteinemia (HP:0003075)1.95329020
164Skin rash (HP:0000988)1.93427715
165Keratoconjunctivitis sicca (HP:0001097)1.92846960
166Genetic anticipation (HP:0003743)1.91478785
167Urticaria (HP:0001025)1.89832552
168Abnormality of renal excretion (HP:0011036)1.89443575
169Hematochezia (HP:0002573)1.89203398
170Vacuolated lymphocytes (HP:0001922)1.89125381
171Hyperaldosteronism (HP:0000859)1.88430465
172Sclerocornea (HP:0000647)1.86966292
173Aplasia/Hypoplasia of the thymus (HP:0010515)1.85669836
174Retinal dysplasia (HP:0007973)1.85551184
175Prominent supraorbital ridges (HP:0000336)1.85298679
176Joint swelling (HP:0001386)1.84021173
177Abnormal ciliary motility (HP:0012262)1.82272572
178Glycosuria (HP:0003076)1.77503000
179Abnormality of urine glucose concentration (HP:0011016)1.77503000
180Abnormality of the pons (HP:0007361)1.76285218
181Hypokalemia (HP:0002900)1.76222124
182Spastic tetraparesis (HP:0001285)1.75539657
183Mesangial abnormality (HP:0001966)1.72997549
184Pulmonary hypoplasia (HP:0002089)1.71956466
185Decreased central vision (HP:0007663)1.70938853
186Absent speech (HP:0001344)1.70541915
187Chorioretinal atrophy (HP:0000533)1.70300082
188Hypoplasia of the pons (HP:0012110)1.70285525
189Cerebellar dysplasia (HP:0007033)1.69182726
190Brushfield spots (HP:0001088)1.68816154
191Male pseudohermaphroditism (HP:0000037)1.67761739
192Abolished electroretinogram (ERG) (HP:0000550)1.65226735
193Patellar aplasia (HP:0006443)1.63027792
194Abnormal albumin level (HP:0012116)1.62993039
195Hypoalbuminemia (HP:0003073)1.62993039
196Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59235868
197Aplasia/Hypoplasia of the uvula (HP:0010293)1.58705371
198Anencephaly (HP:0002323)1.58484436
199Gait imbalance (HP:0002141)1.55585867
200Aplasia/hypoplasia of the uterus (HP:0008684)1.55475246

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.35742690
2PINK14.75369935
3BMPR1B3.51196387
4TXK3.47810407
5ADRBK23.18647072
6TYK23.12689196
7TLK12.97170822
8CASK2.90180574
9TNIK2.88857505
10PNCK2.85472759
11CAMKK22.64071869
12BLK2.61555709
13STK102.60688435
14GRK62.54927219
15MAPK152.51333325
16JAK32.50889109
17ERN12.32021913
18ZAP702.31379377
19IKBKE2.31263111
20GRK12.24781807
21IRAK42.21202778
22TBK12.20252190
23JAK12.18679485
24ITK2.18634735
25KIT2.17378579
26MAP3K142.10441859
27INSRR2.09324418
28BTK2.06006175
29TYRO32.03051956
30WNK42.00296455
31MAP3K101.96781745
32TEC1.93733082
33MAPK131.92083503
34SYK1.83366933
35WNK31.80683260
36MST41.79646842
37FGFR41.74333759
38CSF1R1.68839276
39ZAK1.68368210
40CSK1.67451730
41MAP3K131.59439510
42LCK1.55129979
43LRRK21.55087825
44HCK1.52838411
45DAPK21.46018818
46PKN21.44553359
47PIK3CA1.44469694
48MAP3K41.43509713
49DYRK21.41068790
50FGFR31.39436436
51FES1.37651490
52RIPK41.36897101
53MAP4K21.35188004
54BRSK21.33689190
55FLT31.30532908
56TAOK31.29465151
57IRAK31.26927394
58EEF2K1.23341500
59CAMKK11.22942653
60MAP2K31.22172112
61MARK31.21937038
62OXSR11.21214950
63KDR1.19992709
64MAP2K71.17524084
65TTN1.14848031
66LYN1.14527490
67MARK11.13759406
68IKBKB1.12882740
69ADRBK11.12275341
70PTK2B1.08214584
71CLK11.08211591
72EPHB11.04977234
73PIM11.02658375
74TGFBR21.01323302
75PRKCG0.98080154
76NLK0.97417015
77VRK10.95492380
78STK390.90782416
79JAK20.89910841
80PRKCQ0.82800812
81NTRK20.82554284
82SIK20.79746656
83PIK3CG0.78981949
84ERBB20.77320833
85TESK20.76197032
86WEE10.75552700
87RPS6KA40.73795466
88STK40.73143909
89PIM20.72935271
90NTRK30.70746179
91MAP2K40.70005066
92STK110.69068641
93ACVR1B0.67314101
94EPHB20.66102708
95TSSK60.64409265
96DYRK1A0.64313155
97DYRK1B0.63365984
98PRKCE0.62936957
99MAPKAPK50.62892882
100CHUK0.61945699
101IRAK10.61472120
102NME20.61262311
103TGFBR10.60571885
104CDK40.59576991
105CAMK2A0.59393202
106PTK60.59145016
107TRIB30.58920867
108CDK120.58857895
109PRKCH0.58199801
110MAP3K70.57957466
111RIPK10.57841126
112MAPK40.57302789
113MKNK20.57288486
114RPS6KA50.55485877
115GRK70.52605117
116PDK10.52553564
117CSNK1G20.52038766
118EPHA40.50959387
119MATK0.50475887
120MAP3K80.49039817
121PRKCZ0.48296897
122PRKACA0.48254695
123PRKG20.46705057
124PAK30.45756690
125NEK20.45705093
126RAF10.44718542
127EPHA30.44337878
128MAP2K20.44224654
129MAP2K60.44043113
130HIPK20.43569598
131MAPK110.43317044
132PRKAA10.43088616
133NEK90.42856639
134CDK60.40849160
135TRPM70.40108569
136TIE10.40043295
137PRKCA0.39774821
138TNK20.39716367
139RPS6KA60.39209059
140FYN0.38802267
141EIF2AK30.38469398
142TAF10.38073068
143SIK30.37873904
144ABL10.37860863
145CAMK10.37833648
146CAMK40.36980146
147PRKCD0.36946883
148PRKACG0.36615864
149TAOK10.36485315
150MUSK0.36377773
151PKN10.35960464
152DMPK0.34529622
153CAMK1D0.33909309
154MAP3K30.33494064
155MAPKAPK20.33439164
156PHKG10.33361124
157PHKG20.33361124
158EGFR0.32763339
159RPS6KC10.32232245
160RPS6KL10.32232245
161NME10.32108981
162IGF1R0.31637535
163MAPKAPK30.31405638
164CSNK1A10.30797005
165MAP2K10.30351741
166CAMK2B0.30278539
167PRKAA20.29870517
168DYRK30.29645446
169ALK0.28228780
170OBSCN0.27444383
171FRK0.26960824
172NUAK10.26035041
173MELK0.26007656
174ATR0.25881864
175STK38L0.25761003
176FGFR20.25700052
177MAPK30.23778345
178SCYL20.23666264
179MAP3K50.20798454

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.57457694
2Linoleic acid metabolism_Homo sapiens_hsa005913.06862167
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.92332926
4B cell receptor signaling pathway_Homo sapiens_hsa046622.89022530
5Leishmaniasis_Homo sapiens_hsa051402.77372216
6Tryptophan metabolism_Homo sapiens_hsa003802.71998315
7Histidine metabolism_Homo sapiens_hsa003402.55421547
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.53828059
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.53379638
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.51518710
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47578796
12Antigen processing and presentation_Homo sapiens_hsa046122.45537868
13Measles_Homo sapiens_hsa051622.43062933
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.32421073
15Hematopoietic cell lineage_Homo sapiens_hsa046402.31524000
16Nitrogen metabolism_Homo sapiens_hsa009102.22937090
17Osteoclast differentiation_Homo sapiens_hsa043802.22532651
18Caffeine metabolism_Homo sapiens_hsa002322.20793723
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.16755973
20T cell receptor signaling pathway_Homo sapiens_hsa046602.15902324
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01630674
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.00486257
23Phototransduction_Homo sapiens_hsa047441.98523777
24Chemical carcinogenesis_Homo sapiens_hsa052041.88444844
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.88222213
26Herpes simplex infection_Homo sapiens_hsa051681.85255942
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84612444
28Graft-versus-host disease_Homo sapiens_hsa053321.80326664
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.78129645
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76354783
31Butanoate metabolism_Homo sapiens_hsa006501.73786139
32Nicotine addiction_Homo sapiens_hsa050331.72568464
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71808734
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70358656
35Sulfur relay system_Homo sapiens_hsa041221.68565395
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66855959
37Influenza A_Homo sapiens_hsa051641.64489492
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62837025
39Renin-angiotensin system_Homo sapiens_hsa046141.62821345
40Glycerolipid metabolism_Homo sapiens_hsa005611.62324759
41Ether lipid metabolism_Homo sapiens_hsa005651.62079205
42Allograft rejection_Homo sapiens_hsa053301.60437848
43Retinol metabolism_Homo sapiens_hsa008301.60153287
44Staphylococcus aureus infection_Homo sapiens_hsa051501.57812428
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57197548
46Toxoplasmosis_Homo sapiens_hsa051451.57099028
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56184777
48Bile secretion_Homo sapiens_hsa049761.54774954
49Viral myocarditis_Homo sapiens_hsa054161.51568018
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.51447987
51Selenocompound metabolism_Homo sapiens_hsa004501.48770002
52Tuberculosis_Homo sapiens_hsa051521.47081617
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45106954
54Legionellosis_Homo sapiens_hsa051341.44885438
55Insulin secretion_Homo sapiens_hsa049111.44427832
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.44295998
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42753994
58Pertussis_Homo sapiens_hsa051331.38795678
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36873710
60Oxidative phosphorylation_Homo sapiens_hsa001901.31193849
61Apoptosis_Homo sapiens_hsa042101.31029213
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.30559691
63Arachidonic acid metabolism_Homo sapiens_hsa005901.30374405
64Taste transduction_Homo sapiens_hsa047421.29255018
65Hepatitis B_Homo sapiens_hsa051611.28404650
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26603158
67Cocaine addiction_Homo sapiens_hsa050301.26420957
68Shigellosis_Homo sapiens_hsa051311.25830555
69Chemokine signaling pathway_Homo sapiens_hsa040621.23258350
70Hepatitis C_Homo sapiens_hsa051601.19722329
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18613303
72TNF signaling pathway_Homo sapiens_hsa046681.18333262
73Malaria_Homo sapiens_hsa051441.18227315
74Acute myeloid leukemia_Homo sapiens_hsa052211.17402724
75Protein digestion and absorption_Homo sapiens_hsa049741.14880176
76beta-Alanine metabolism_Homo sapiens_hsa004101.12693723
77Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11468885
78Fatty acid biosynthesis_Homo sapiens_hsa000611.08311097
79Fat digestion and absorption_Homo sapiens_hsa049751.05935757
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05664593
81Ovarian steroidogenesis_Homo sapiens_hsa049131.04623518
82Peroxisome_Homo sapiens_hsa041461.04294508
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04261569
84Salivary secretion_Homo sapiens_hsa049701.02862386
85Morphine addiction_Homo sapiens_hsa050321.00949343
86Other glycan degradation_Homo sapiens_hsa005111.00856096
87Parkinsons disease_Homo sapiens_hsa050121.00572485
88Platelet activation_Homo sapiens_hsa046110.99971022
89Salmonella infection_Homo sapiens_hsa051320.93772666
90Calcium signaling pathway_Homo sapiens_hsa040200.93637647
91Serotonergic synapse_Homo sapiens_hsa047260.91419208
92Fatty acid degradation_Homo sapiens_hsa000710.90218431
93Pancreatic cancer_Homo sapiens_hsa052120.88918810
94Chronic myeloid leukemia_Homo sapiens_hsa052200.87262276
95Non-homologous end-joining_Homo sapiens_hsa034500.85645246
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83245310
97Arginine and proline metabolism_Homo sapiens_hsa003300.81782901
98Autoimmune thyroid disease_Homo sapiens_hsa053200.81389940
99Asthma_Homo sapiens_hsa053100.80977536
100Cardiac muscle contraction_Homo sapiens_hsa042600.79050636
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78879595
102Epstein-Barr virus infection_Homo sapiens_hsa051690.77945390
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76950302
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76190228
105Olfactory transduction_Homo sapiens_hsa047400.74174851
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73912716
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72998992
108Circadian entrainment_Homo sapiens_hsa047130.72109364
109Amphetamine addiction_Homo sapiens_hsa050310.72103844
110VEGF signaling pathway_Homo sapiens_hsa043700.71322429
111DNA replication_Homo sapiens_hsa030300.71220828
112Dopaminergic synapse_Homo sapiens_hsa047280.70946005
113Thyroid hormone synthesis_Homo sapiens_hsa049180.69619325
114PPAR signaling pathway_Homo sapiens_hsa033200.69216994
115Mineral absorption_Homo sapiens_hsa049780.68379478
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67645500
117Small cell lung cancer_Homo sapiens_hsa052220.66111759
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65012713
119GABAergic synapse_Homo sapiens_hsa047270.64980001
120Protein export_Homo sapiens_hsa030600.64722445
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.64367925
122African trypanosomiasis_Homo sapiens_hsa051430.63809272
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63299926
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.63012277
125Gastric acid secretion_Homo sapiens_hsa049710.62950436
126Glutamatergic synapse_Homo sapiens_hsa047240.62797696
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.62761337
128Galactose metabolism_Homo sapiens_hsa000520.62331068
129Viral carcinogenesis_Homo sapiens_hsa052030.61972081
130Base excision repair_Homo sapiens_hsa034100.61801810
131Alzheimers disease_Homo sapiens_hsa050100.61729520
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.60973877
133Insulin resistance_Homo sapiens_hsa049310.60843482
134Lysosome_Homo sapiens_hsa041420.60501208
135HTLV-I infection_Homo sapiens_hsa051660.60165757
136Pancreatic secretion_Homo sapiens_hsa049720.58445315
137Non-small cell lung cancer_Homo sapiens_hsa052230.56744145
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55632561
139Huntingtons disease_Homo sapiens_hsa050160.55307784
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55287022
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53273463
142HIF-1 signaling pathway_Homo sapiens_hsa040660.52529952
143Pentose phosphate pathway_Homo sapiens_hsa000300.50270158
144Regulation of autophagy_Homo sapiens_hsa041400.50174129
145Steroid biosynthesis_Homo sapiens_hsa001000.50157914
146p53 signaling pathway_Homo sapiens_hsa041150.49492262
147Prolactin signaling pathway_Homo sapiens_hsa049170.49065442
148Long-term depression_Homo sapiens_hsa047300.48972270
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.47932446
150Primary bile acid biosynthesis_Homo sapiens_hsa001200.46533997
151Sulfur metabolism_Homo sapiens_hsa009200.46142194
152Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45126391
153Starch and sucrose metabolism_Homo sapiens_hsa005000.44522534
154Cholinergic synapse_Homo sapiens_hsa047250.44507768
155ABC transporters_Homo sapiens_hsa020100.43878475
156Renin secretion_Homo sapiens_hsa049240.43298654
157Ribosome_Homo sapiens_hsa030100.42998701
158Propanoate metabolism_Homo sapiens_hsa006400.42532835
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42200795
160Vitamin digestion and absorption_Homo sapiens_hsa049770.39484466
161Sphingolipid signaling pathway_Homo sapiens_hsa040710.38944825
162Homologous recombination_Homo sapiens_hsa034400.38386992
163Colorectal cancer_Homo sapiens_hsa052100.37957888
164Metabolic pathways_Homo sapiens_hsa011000.36113448
165Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35600817
166Notch signaling pathway_Homo sapiens_hsa043300.33649826
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.32573897
168Axon guidance_Homo sapiens_hsa043600.32189978
169Pyruvate metabolism_Homo sapiens_hsa006200.31228480
170Basal cell carcinoma_Homo sapiens_hsa052170.31221631
171Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30652608
172Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30345178
173Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30008703
174Type I diabetes mellitus_Homo sapiens_hsa049400.29564683
175Phagosome_Homo sapiens_hsa041450.29489323
176Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28770566
177Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28119259
178Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27824356
179TGF-beta signaling pathway_Homo sapiens_hsa043500.27416412
180Lysine degradation_Homo sapiens_hsa003100.27145781
181Type II diabetes mellitus_Homo sapiens_hsa049300.25780851
182Amoebiasis_Homo sapiens_hsa051460.24568878
183Mismatch repair_Homo sapiens_hsa034300.24128604
184FoxO signaling pathway_Homo sapiens_hsa040680.22957729
185Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22030560

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