SLC28A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide biosynthetic process (GO:0009312)8.95213421
2positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)8.57666185
3positive regulation of p38MAPK cascade (GO:1900745)8.13395151
4pattern specification involved in kidney development (GO:0061004)7.03572554
5oligosaccharide catabolic process (GO:0009313)6.50431335
6glycosphingolipid catabolic process (GO:0046479)6.28187525
7positive regulation of bone resorption (GO:0045780)6.07742983
8positive regulation of bone remodeling (GO:0046852)6.07742983
9regulation of syncytium formation by plasma membrane fusion (GO:0060142)6.04019635
10regulation of vascular endothelial growth factor signaling pathway (GO:1900746)6.02960871
11glycolipid catabolic process (GO:0019377)5.77294758
12amino sugar catabolic process (GO:0046348)5.68496902
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.58838158
14glucosamine-containing compound catabolic process (GO:1901072)5.45298132
15linoleic acid metabolic process (GO:0043651)5.38878644
16positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr5.36388410
17N-acetylneuraminate metabolic process (GO:0006054)5.19439502
18detection of molecule of bacterial origin (GO:0032490)5.16577536
19osteoclast differentiation (GO:0030316)5.07758353
20regulation of p38MAPK cascade (GO:1900744)5.01193148
21interferon-gamma secretion (GO:0072643)4.94371256
22cellular extravasation (GO:0045123)4.94055023
23negative regulation of keratinocyte proliferation (GO:0010839)4.90784670
24regulation of monocyte differentiation (GO:0045655)4.90240775
25nephron epithelium morphogenesis (GO:0072088)4.68020331
26nephron tubule morphogenesis (GO:0072078)4.68020331
27lactation (GO:0007595)4.65775599
28regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 4.59422142
29ectoderm development (GO:0007398)4.55890307
30regulation of sequestering of triglyceride (GO:0010889)4.51299522
31superoxide anion generation (GO:0042554)4.46390403
32pinocytosis (GO:0006907)4.43869820
33fatty-acyl-CoA biosynthetic process (GO:0046949)4.32868047
34regulation of cholesterol storage (GO:0010885)4.31645703
35long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.30978257
36mammary gland epithelial cell differentiation (GO:0060644)4.24796860
37positive regulation of tissue remodeling (GO:0034105)4.23685677
38negative regulation of execution phase of apoptosis (GO:1900118)4.19346742
39lung epithelium development (GO:0060428)4.18687604
40sphingolipid catabolic process (GO:0030149)4.17563193
41keratinocyte development (GO:0003334)4.17453728
42cellular response to thyroid hormone stimulus (GO:0097067)4.16346347
43acyl-CoA biosynthetic process (GO:0071616)4.12556244
44thioester biosynthetic process (GO:0035384)4.12556244
45membrane lipid catabolic process (GO:0046466)4.11361755
46regulation of transforming growth factor beta1 production (GO:0032908)4.09110737
47regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.08796690
48regulation of apoptotic process involved in morphogenesis (GO:1902337)4.06010997
49neutrophil activation involved in immune response (GO:0002283)4.05826962
50transferrin transport (GO:0033572)3.99086434
51secretion by tissue (GO:0032941)3.98375504
52replicative senescence (GO:0090399)3.97595150
53keratinization (GO:0031424)3.97108075
54phagosome maturation (GO:0090382)3.96392621
55peptide catabolic process (GO:0043171)3.94281472
56folic acid transport (GO:0015884)3.92703689
57DNA damage induced protein phosphorylation (GO:0006975)3.92416062
58renal tubule morphogenesis (GO:0061333)3.90231811
59apoptotic cell clearance (GO:0043277)3.88746030
60copper ion transport (GO:0006825)3.85758323
61fat-soluble vitamin biosynthetic process (GO:0042362)3.81880795
62positive regulation of monocyte chemotaxis (GO:0090026)3.80214222
63iron ion import (GO:0097286)3.73881680
64ferric iron transport (GO:0015682)3.73215079
65trivalent inorganic cation transport (GO:0072512)3.73215079
66ceramide catabolic process (GO:0046514)3.70369708
67biotin metabolic process (GO:0006768)3.68954613
68oligosaccharide metabolic process (GO:0009311)3.67903250
69O-glycan processing (GO:0016266)3.65958777
70carnitine shuttle (GO:0006853)3.65166209
71response to peptidoglycan (GO:0032494)3.63296517
72eosinophil migration (GO:0072677)3.62531875
73positive regulation of toll-like receptor signaling pathway (GO:0034123)3.60553887
74eosinophil chemotaxis (GO:0048245)3.53574454
75response to host immune response (GO:0052572)3.52787414
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.52787414
77regulation of endothelial cell differentiation (GO:0045601)3.49766947
78decidualization (GO:0046697)3.49550692
79detection of external biotic stimulus (GO:0098581)3.44255789
80response to host (GO:0075136)3.42343316
81response to host defenses (GO:0052200)3.42343316
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42343316
83body fluid secretion (GO:0007589)3.39794560
84myeloid dendritic cell differentiation (GO:0043011)3.38946488
85fatty acid transmembrane transport (GO:1902001)3.37158046
86segment specification (GO:0007379)3.35401718
87metanephric nephron tubule development (GO:0072234)3.32807795
88metanephric tubule development (GO:0072170)3.32807795
89positive regulation of osteoclast differentiation (GO:0045672)3.32712237
90cell differentiation involved in metanephros development (GO:0072202)3.32190394
91response to thyroid hormone (GO:0097066)3.32045448
92desmosome organization (GO:0002934)3.28617390
93regulation of nuclear cell cycle DNA replication (GO:0033262)3.24929814
94positive regulation of leukocyte degranulation (GO:0043302)3.24876836
95long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.23816881
96positive regulation by symbiont of host defense response (GO:0052509)3.20864926
97modulation by symbiont of host defense response (GO:0052031)3.20864926
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20864926
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20864926
100positive regulation by organism of defense response of other organism involved in symbiotic interact3.20864926
101modulation by symbiont of host immune response (GO:0052553)3.20864926
102negative regulation of transcription by competitive promoter binding (GO:0010944)3.20256320
103detection of other organism (GO:0098543)3.18701868
104barbed-end actin filament capping (GO:0051016)3.17514446
105collecting duct development (GO:0072044)3.14733321
106mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12227310
107mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12227310
108hepatocyte differentiation (GO:0070365)3.12147200
109positive regulation of mast cell activation (GO:0033005)3.11683817
110regulation of cholesterol homeostasis (GO:2000188)3.11627316
111lipid storage (GO:0019915)3.11562303
112positive regulation of mast cell degranulation (GO:0043306)3.11430609
113positive regulation of mast cell activation involved in immune response (GO:0033008)3.11430609
114mitochondrial calcium ion transport (GO:0006851)3.07857052
115establishment of skin barrier (GO:0061436)3.06532424
116regulation of water loss via skin (GO:0033561)3.05859468
117activation of MAPKKK activity (GO:0000185)3.04587840
118sphingosine metabolic process (GO:0006670)3.03239559
119very-low-density lipoprotein particle assembly (GO:0034379)3.02967702
120pH reduction (GO:0045851)3.02667311
121regulation of mononuclear cell migration (GO:0071675)3.02025615
122neural tube formation (GO:0001841)3.02011257
123negative regulation of systemic arterial blood pressure (GO:0003085)3.01957076
124metanephric nephron epithelium development (GO:0072243)3.01674644
125intracellular pH reduction (GO:0051452)3.00931564
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00369686
127ATP hydrolysis coupled proton transport (GO:0015991)3.00369686
128regulation of bone resorption (GO:0045124)2.99150122
129phosphate ion homeostasis (GO:0055062)2.98415062
130trivalent inorganic anion homeostasis (GO:0072506)2.98415062
131regulation of vitamin D biosynthetic process (GO:0060556)2.97798446
132hemidesmosome assembly (GO:0031581)2.97637993
133negative regulation of lipid storage (GO:0010888)2.96911531
134regulation of penile erection (GO:0060405)2.96740947
135response to progesterone (GO:0032570)2.96616635
136iron ion transport (GO:0006826)2.95514063
137chronic inflammatory response (GO:0002544)2.95450385
138tooth mineralization (GO:0034505)2.95199828
139cellular anion homeostasis (GO:0030002)2.94886111
140positive regulation of receptor recycling (GO:0001921)2.94341500
141vitamin D metabolic process (GO:0042359)2.93934950
142facial nerve structural organization (GO:0021612)2.93571582
143regulation of mast cell degranulation (GO:0043304)2.93110583
144positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92892575
145transcytosis (GO:0045056)2.92158057
146regulation of monocyte chemotaxis (GO:0090025)2.90852698
147response to magnesium ion (GO:0032026)2.89644073
148myeloid dendritic cell activation (GO:0001773)2.89203776
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88163096
150polyol transport (GO:0015791)2.84480095
151lipoxygenase pathway (GO:0019372)2.82832871
152positive regulation of cellular amide metabolic process (GO:0034250)2.82336278
153positive regulation of cholesterol efflux (GO:0010875)2.81364345
154negative regulation of interleukin-12 production (GO:0032695)2.80816392
155regulation of mitotic spindle organization (GO:0060236)2.80709458
156metanephric epithelium development (GO:0072207)2.80042819
157negative regulation of DNA-dependent DNA replication (GO:2000104)2.78879952
158regulation of mast cell activation involved in immune response (GO:0033006)2.78455546
159detection of bacterium (GO:0016045)2.77828712
160growth hormone receptor signaling pathway (GO:0060396)2.77500762
161regulation of leukocyte degranulation (GO:0043300)2.76239847
162negative regulation of nitric oxide biosynthetic process (GO:0045019)2.75767321
163detection of biotic stimulus (GO:0009595)2.75470924
164* pyrimidine-containing compound transmembrane transport (GO:0072531)2.73770026
165keratan sulfate catabolic process (GO:0042340)2.73092287
166otic vesicle formation (GO:0030916)2.72515630
167bundle of His cell to Purkinje myocyte communication (GO:0086069)2.72421821
168diol metabolic process (GO:0034311)2.71922751
169fatty-acyl-CoA metabolic process (GO:0035337)2.71236646
170granulocyte activation (GO:0036230)2.70728994
171regulation of mast cell activation (GO:0033003)2.70187187
172negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.69977421
173regulation of macrophage derived foam cell differentiation (GO:0010743)2.69654218
174ganglioside metabolic process (GO:0001573)2.69541763
175phagocytosis, recognition (GO:0006910)2.69529158
176positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.69374108
177embryonic process involved in female pregnancy (GO:0060136)2.68740954
178regulation of macrophage chemotaxis (GO:0010758)2.68061010
179carnitine transmembrane transport (GO:1902603)2.67250719
180granulocyte chemotaxis (GO:0071621)2.66385577
181production of molecular mediator involved in inflammatory response (GO:0002532)2.66277647
182granulocyte migration (GO:0097530)2.63328708
183positive regulation of odontogenesis (GO:0042482)2.62203455
184neutrophil chemotaxis (GO:0030593)2.62190791
185regulation of hypersensitivity (GO:0002883)2.62083710
186protein localization to endosome (GO:0036010)2.61018042
187lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60888045
188regulation of myeloid leukocyte mediated immunity (GO:0002886)2.60887402
189regulation of intracellular pH (GO:0051453)2.58572710
190respiratory burst (GO:0045730)2.57003749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse6.84747261
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.96968795
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.77775201
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61009547
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.54117767
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.48567353
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.23379168
8CDX2_19796622_ChIP-Seq_MESCs_Mouse3.20142823
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15128176
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00790170
11AR_21572438_ChIP-Seq_LNCaP_Human2.81839820
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74713041
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.46818996
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.25390337
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15081038
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.13172318
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06051116
18* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03710387
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.01230954
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93996943
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.92465576
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.85052325
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84699904
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84192430
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82619684
26GATA4_25053715_ChIP-Seq_YYC3_Human1.82526276
27* SOX2_20726797_ChIP-Seq_SW620_Human1.77584319
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72396678
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.71521671
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64761597
31SCL_19346495_ChIP-Seq_HPC-7_Human1.63429294
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.62768020
33STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61857159
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.61615147
35SPI1_23127762_ChIP-Seq_K562_Human1.60694087
36VDR_24763502_ChIP-Seq_THP-1_Human1.58995517
37GATA1_22025678_ChIP-Seq_K562_Human1.58384460
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57048132
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55610967
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.55297933
41* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54037911
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53804551
43AHR_22903824_ChIP-Seq_MCF-7_Human1.53448371
44* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49948695
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.48204250
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48109917
47ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45794757
48SPI1_23547873_ChIP-Seq_NB4_Human1.44695170
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44284165
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.43357130
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.42319924
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.41245044
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.40671850
54CJUN_26792858_Chip-Seq_BT549_Human1.40098958
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39702708
56STAT3_18555785_Chip-Seq_ESCs_Mouse1.39227750
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.37146336
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36631071
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35524048
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35407654
61SOX2_18555785_Chip-Seq_ESCs_Mouse1.34433104
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.34012168
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32822271
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32601015
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30938710
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.29466773
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28406378
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27973997
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27973997
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26354149
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25826762
72STAT1_17558387_ChIP-Seq_HELA_Human1.25688179
73TP53_18474530_ChIP-ChIP_U2OS_Human1.25535276
74PU_27001747_Chip-Seq_BMDM_Mouse1.25159711
75* TP63_23658742_ChIP-Seq_EP156T_Human1.25094883
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24188793
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23699980
78RXR_22108803_ChIP-Seq_LS180_Human1.23592809
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.22779293
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.21847249
81OCT4_18555785_Chip-Seq_ESCs_Mouse1.21060393
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19475151
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.18755018
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18654587
85RXR_22158963_ChIP-Seq_LIVER_Mouse1.17855848
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17796948
87TFEB_21752829_ChIP-Seq_HELA_Human1.17545603
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17436790
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17256899
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16975924
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16814675
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.16612695
93ZFX_18555785_Chip-Seq_ESCs_Mouse1.16097528
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15586971
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14518543
96P53_22387025_ChIP-Seq_ESCs_Mouse1.14324597
97* KLF5_25053715_ChIP-Seq_YYC3_Human1.14259256
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12437460
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12345917
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12327849
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.11902972
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11646538
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11335325
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11316973
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10954696
106EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10760583
107LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10626916
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10179959
109PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10115442
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09695503
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08247288
112PU1_27457419_Chip-Seq_LIVER_Mouse1.07632488
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.07411395
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07395957
115* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06709221
116SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06445901
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.06409055
118* TCF4_22108803_ChIP-Seq_LS180_Human1.06034254
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.05470845
120P300_18555785_Chip-Seq_ESCs_Mouse1.05408507
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04902518
122GATA3_24758297_ChIP-Seq_MCF-7_Human1.04283301
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03937523
124GATA1_19941826_ChIP-Seq_K562_Human1.02674017
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01893859
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00764010
127VDR_24787735_ChIP-Seq_THP-1_Human1.00584707
128STAT1_20625510_ChIP-Seq_HELA_Human1.00425277
129NMYC_18555785_Chip-Seq_ESCs_Mouse1.00271388
130SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99810871
131AR_25329375_ChIP-Seq_VCAP_Human0.99706199
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.99633717
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99509724
134LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98931437
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98049507
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97173870
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96794165
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96731267
139FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95624652
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95470521
141CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95335348
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95025379
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94436480
144RUNX_20019798_ChIP-Seq_JUKART_Human0.94276395
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93864697
146GATA2_19941826_ChIP-Seq_K562_Human0.93491420
147* CDX2_22108803_ChIP-Seq_LS180_Human0.92245439
148FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91630236
149IRF1_19129219_ChIP-ChIP_H3396_Human0.89373072
150TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88934839
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88527157
152STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87717152
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87333319
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87266721
155GATA6_25053715_ChIP-Seq_YYC3_Human0.86821219
156* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86690923
157AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86563735
158CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86287553
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.85483788
160RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85306854
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83291961
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83271038
163GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83261575
164PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82151742
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.81451951
166SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80701865
167GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80164025
168GATA3_26560356_Chip-Seq_TH2_Human0.78034368
169* TBX20_22328084_ChIP-Seq_HEART_Mouse0.78034247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001881_abnormal_mammary_gland9.88251611
2MP0003191_abnormal_cellular_cholesterol4.30231181
3MP0009840_abnormal_foam_cell4.17062434
4MP0003045_fibrosis4.01686224
5MP0005058_abnormal_lysosome_morphology3.58391066
6MP0003136_yellow_coat_color3.43727653
7MP0000627_abnormal_mammary_gland3.26909531
8MP0002139_abnormal_hepatobiliary_system3.10908149
9MP0003300_gastrointestinal_ulcer3.02123454
10MP0010234_abnormal_vibrissa_follicle2.97886024
11MP0000604_amyloidosis2.88296842
12MP0003172_abnormal_lysosome_physiology2.84321106
13MP0001873_stomach_inflammation2.77748142
14MP0004019_abnormal_vitamin_homeostasis2.76221491
15MP0002138_abnormal_hepatobiliary_system2.61192320
16MP0000566_synostosis2.58179807
17MP0002877_abnormal_melanocyte_morpholog2.37118739
18MP0002254_reproductive_system_inflammat2.35181349
19MP0002168_other_aberrant_phenotype2.30979304
20MP0003806_abnormal_nucleotide_metabolis2.29378919
21MP0006082_CNS_inflammation2.27476780
22MP0003950_abnormal_plasma_membrane2.27390017
23MP0003329_amyloid_beta_deposits2.25334474
24MP0005171_absent_coat_pigmentation2.25247002
25MP0003724_increased_susceptibility_to2.23408823
26MP0004147_increased_porphyrin_level2.13343508
27MP0004264_abnormal_extraembryonic_tissu2.13067605
28MP0005395_other_phenotype2.07569233
29MP0005365_abnormal_bile_salt2.05330975
30MP0005451_abnormal_body_composition2.02445027
31MP0005083_abnormal_biliary_tract1.98073118
32MP0003436_decreased_susceptibility_to1.96397179
33MP0010386_abnormal_urinary_bladder1.95528476
34MP0002928_abnormal_bile_duct1.93553447
35MP0003303_peritoneal_inflammation1.92592770
36MP0002796_impaired_skin_barrier1.87697844
37MP0003718_maternal_effect1.84291563
38MP0001188_hyperpigmentation1.83667876
39MP0000343_altered_response_to1.83263833
40MP0002098_abnormal_vibrissa_morphology1.80610805
41MP0001853_heart_inflammation1.77098578
42MP0003941_abnormal_skin_development1.76572812
43MP0003252_abnormal_bile_duct1.76226074
44MP0004381_abnormal_hair_follicle1.72471327
45MP0010678_abnormal_skin_adnexa1.66301279
46MP0001666_abnormal_nutrient_absorption1.64139272
47MP0005025_abnormal_response_to1.57998402
48MP0005501_abnormal_skin_physiology1.50763785
49MP0001790_abnormal_immune_system1.50483784
50MP0005387_immune_system_phenotype1.50483784
51MP0001664_abnormal_digestion1.48421152
52MP0005671_abnormal_response_to1.48398699
53MP0002452_abnormal_antigen_presenting1.46479799
54MP0000383_abnormal_hair_follicle1.44563937
55MP0003828_pulmonary_edema1.43037049
56MP0001545_abnormal_hematopoietic_system1.39700578
57MP0005397_hematopoietic_system_phenotyp1.39700578
58MP0000490_abnormal_crypts_of1.35747748
59MP0003656_abnormal_erythrocyte_physiolo1.33410624
60MP0005220_abnormal_exocrine_pancreas1.33341883
61MP0005670_abnormal_white_adipose1.31241096
62MP0005645_abnormal_hypothalamus_physiol1.30636676
63MP0001533_abnormal_skeleton_physiology1.29468110
64MP0009333_abnormal_splenocyte_physiolog1.26689258
65MP0002277_abnormal_respiratory_mucosa1.25604352
66MP0005000_abnormal_immune_tolerance1.24937465
67MP0009278_abnormal_bone_marrow1.24324743
68MP0002148_abnormal_hypersensitivity_rea1.23772804
69MP0005275_abnormal_skin_tensile1.23237755
70MP0003936_abnormal_reproductive_system1.22494979
71MP0009764_decreased_sensitivity_to1.20124571
72MP0010352_gastrointestinal_tract_polyps1.19146862
73MP0002009_preneoplasia1.18897602
74MP0004272_abnormal_basement_membrane1.16493477
75MP0000377_abnormal_hair_follicle1.13510066
76MP0005464_abnormal_platelet_physiology1.12672881
77MP0005647_abnormal_sex_gland1.10180794
78MP0005257_abnormal_intraocular_pressure1.09631962
79MP0003075_altered_response_to1.08858946
80MP0008438_abnormal_cutaneous_collagen1.06291446
81MP0005023_abnormal_wound_healing1.05707826
82MP0002249_abnormal_larynx_morphology1.04955951
83MP0002723_abnormal_immune_serum1.03490117
84MP0001765_abnormal_ion_homeostasis1.02760519
85MP0008260_abnormal_autophagy1.02675143
86MP0002420_abnormal_adaptive_immunity1.02143292
87MP0000465_gastrointestinal_hemorrhage1.01466664
88MP0001177_atelectasis1.01003673
89MP0005166_decreased_susceptibility_to1.00593020
90MP0004782_abnormal_surfactant_physiolog1.00528337
91MP0001819_abnormal_immune_cell1.00264083
92MP0001270_distended_abdomen0.98639638
93MP0002896_abnormal_bone_mineralization0.97270028
94MP0005085_abnormal_gallbladder_physiolo0.97099489
95MP0001663_abnormal_digestive_system0.96563425
96MP0002060_abnormal_skin_morphology0.95337125
97MP0000579_abnormal_nail_morphology0.94772203
98MP0003690_abnormal_glial_cell0.94069207
99MP0002396_abnormal_hematopoietic_system0.93635217
100MP0001800_abnormal_humoral_immune0.93473901
101MP0000427_abnormal_hair_cycle0.93073248
102MP0004130_abnormal_muscle_cell0.92233608
103MP0000647_abnormal_sebaceous_gland0.92213890
104MP0001216_abnormal_epidermal_layer0.91960403
105MP0002405_respiratory_system_inflammati0.91884325
106MP0003878_abnormal_ear_physiology0.91640250
107MP0005377_hearing/vestibular/ear_phenot0.91640250
108MP0003566_abnormal_cell_adhesion0.91391099
109MP0005636_abnormal_mineral_homeostasis0.90990809
110MP0004742_abnormal_vestibular_system0.90401436
111MP0003453_abnormal_keratinocyte_physiol0.88899530
112MP0001851_eye_inflammation0.88063304
113MP0002090_abnormal_vision0.86733584
114MP0003011_delayed_dark_adaptation0.86213580
115MP0005164_abnormal_response_to0.85890765
116MP0008469_abnormal_protein_level0.85079059
117MP0001727_abnormal_embryo_implantation0.84129476
118MP0003279_aneurysm0.84003055
119MP0000762_abnormal_tongue_morphology0.83101199
120MP0003787_abnormal_imprinting0.82065810
121MP0001835_abnormal_antigen_presentation0.81546616
122MP0000920_abnormal_myelination0.81328267
123MP0003091_abnormal_cell_migration0.79503190
124MP0000371_diluted_coat_color0.79452296
125MP0005381_digestive/alimentary_phenotyp0.79335066
126MP0000685_abnormal_immune_system0.78702066
127MP0009384_cardiac_valve_regurgitation0.78117668
128MP0005075_abnormal_melanosome_morpholog0.77534488
129MP0004510_myositis0.77408088
130MP0005319_abnormal_enzyme/_coenzyme0.75867805
131MP0001191_abnormal_skin_condition0.75759673
132MP0002006_tumorigenesis0.74389572
133MP0004947_skin_inflammation0.72006584
134MP0009785_altered_susceptibility_to0.71671133
135MP0005084_abnormal_gallbladder_morpholo0.71409296
136MP0002938_white_spotting0.70859613
137MP0000569_abnormal_digit_pigmentation0.70525683
138MP0000678_abnormal_parathyroid_gland0.70235623
139MP0005310_abnormal_salivary_gland0.69682704
140MP0002933_joint_inflammation0.69670011
141MP0000015_abnormal_ear_pigmentation0.69371137
142MP0010771_integument_phenotype0.68981668
143MP0002876_abnormal_thyroid_physiology0.67731397
144MP0002419_abnormal_innate_immunity0.67168988
145MP0005410_abnormal_fertilization0.66727178
146MP0002998_abnormal_bone_remodeling0.65531765
147MP0001958_emphysema0.65510645
148MP0000003_abnormal_adipose_tissue0.65195998
149MP0008004_abnormal_stomach_pH0.64304673
150MP0000467_abnormal_esophagus_morphology0.63708184
151MP0003448_altered_tumor_morphology0.63048510
152MP0001919_abnormal_reproductive_system0.62289134
153MP0005375_adipose_tissue_phenotype0.62033316
154MP0010155_abnormal_intestine_physiology0.61231018
155MP0000462_abnormal_digestive_system0.60411236
156MP0002118_abnormal_lipid_homeostasis0.60183532
157MP0000470_abnormal_stomach_morphology0.59887743
158MP0003795_abnormal_bone_structure0.56531793
159MP0003195_calcinosis0.56110073
160MP0005334_abnormal_fat_pad0.55441144
161MP0001845_abnormal_inflammatory_respons0.51648065
162MP0000613_abnormal_salivary_gland0.50316014

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)8.92169975
2Abnormality of glycosphingolipid metabolism (HP:0004343)8.92169975
3Abnormality of glycolipid metabolism (HP:0010969)8.92169975
4Increased cerebral lipofuscin (HP:0011813)5.45477060
5Stomach cancer (HP:0012126)5.16904973
6Amelogenesis imperfecta (HP:0000705)4.91235752
7Cystic liver disease (HP:0006706)4.63812630
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.63552631
9Neoplasm of the adrenal cortex (HP:0100641)4.56516767
10Abnormality of the renal cortex (HP:0011035)4.55188766
11Congenital ichthyosiform erythroderma (HP:0007431)4.50746775
12Cerebral aneurysm (HP:0004944)4.47937942
13Eczematoid dermatitis (HP:0000976)4.24801516
14Renal cortical cysts (HP:0000803)4.14638851
15Right ventricular cardiomyopathy (HP:0011663)4.11122851
16Loss of speech (HP:0002371)3.99967552
17Abnormality of renal resorption (HP:0011038)3.92127266
18Scanning speech (HP:0002168)3.84494813
19Ectropion (HP:0000656)3.78848065
20Myocardial infarction (HP:0001658)3.67451336
21Dysostosis multiplex (HP:0000943)3.63041210
22Tubulointerstitial nephritis (HP:0001970)3.59114430
23Aplasia cutis congenita (HP:0001057)3.50769550
24Recurrent bacterial skin infections (HP:0005406)3.47592793
25Disinhibition (HP:0000734)3.43591022
26Systemic lupus erythematosus (HP:0002725)3.39194230
27Abnormality of calcium-phosphate metabolism (HP:0100530)3.37166496
28White forelock (HP:0002211)3.33565091
29Abnormality of polysaccharide metabolism (HP:0011012)3.29934230
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29934230
31Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29934230
32Metaphyseal irregularity (HP:0003025)3.29207689
33Abnormality of purine metabolism (HP:0004352)3.16218065
34Recurrent abscess formation (HP:0002722)3.09091505
35Mucopolysacchariduria (HP:0008155)3.06182151
36Urinary glycosaminoglycan excretion (HP:0003541)3.06182151
37Patchy hypopigmentation of hair (HP:0011365)3.04015471
38Bilateral sensorineural hearing impairment (HP:0008619)3.01107842
39Recurrent gram-negative bacterial infections (HP:0005420)2.98342688
40Malnutrition (HP:0004395)2.96563232
41Unilateral renal agenesis (HP:0000122)2.92535522
42Tubulointerstitial fibrosis (HP:0005576)2.89711939
43Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.86820465
44Pili torti (HP:0003777)2.86182646
45Abnormality of nail color (HP:0100643)2.85725859
46Mutism (HP:0002300)2.85150773
47Diminished motivation (HP:0000745)2.84855326
48Apathy (HP:0000741)2.84362158
49Curly hair (HP:0002212)2.83716350
50Gout (HP:0001997)2.83022370
51Abnormality of the periventricular white matter (HP:0002518)2.82282960
52Hypoplasia of dental enamel (HP:0006297)2.78424824
53Paralysis (HP:0003470)2.75442199
54Atrophic scars (HP:0001075)2.74004669
55Onycholysis (HP:0001806)2.72658271
56Neurofibrillary tangles (HP:0002185)2.72612443
57True hermaphroditism (HP:0010459)2.72490400
58Thick nail (HP:0001805)2.70313880
59Optic neuritis (HP:0100653)2.69754718
60Retrobulbar optic neuritis (HP:0100654)2.69754718
61Retinal atrophy (HP:0001105)2.67796931
62Abnormality of renal excretion (HP:0011036)2.65941557
63Hypoplasia of the iris (HP:0007676)2.62727023
64Abnormality of the dental pulp (HP:0006479)2.61857494
65Lip pit (HP:0100267)2.60309242
66Palmoplantar hyperkeratosis (HP:0000972)2.59159220
67Autoimmune thrombocytopenia (HP:0001973)2.56849597
68Alopecia of scalp (HP:0002293)2.53840096
69Pustule (HP:0200039)2.52888253
70Xerostomia (HP:0000217)2.51935543
71Pancreatic cysts (HP:0001737)2.51221014
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.46586307
73Orchitis (HP:0100796)2.46549488
74Cheilitis (HP:0100825)2.45631019
75Xanthomatosis (HP:0000991)2.43998281
76Glomerulosclerosis (HP:0000096)2.43990689
77Cardiovascular calcification (HP:0011915)2.42940016
78Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.40290779
79Palmar hyperkeratosis (HP:0010765)2.40089924
80Increased IgE level (HP:0003212)2.37827796
81Prolonged neonatal jaundice (HP:0006579)2.36935674
82Protuberant abdomen (HP:0001538)2.36360612
83Vascular calcification (HP:0004934)2.35882714
84Stage 5 chronic kidney disease (HP:0003774)2.34747592
85Abnormality of the costochondral junction (HP:0000919)2.32809455
86Increased serum ferritin (HP:0003281)2.32213680
87Tubular atrophy (HP:0000092)2.29772322
88Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25611574
89Erythema (HP:0010783)2.24766550
90Epidermoid cyst (HP:0200040)2.24218553
91Recurrent skin infections (HP:0001581)2.23682508
92Abnormality of the nasal septum (HP:0000419)2.23551453
93Aortic dissection (HP:0002647)2.22269942
94Hyperphosphatemia (HP:0002905)2.22114857
95Hepatosplenomegaly (HP:0001433)2.20487837
96Milia (HP:0001056)2.20166229
97Breast carcinoma (HP:0003002)2.19917797
98Abnormality of the renal medulla (HP:0100957)2.15786166
99Widely patent fontanelles and sutures (HP:0004492)2.15744107
100Nephritis (HP:0000123)2.15114651
101Vacuolated lymphocytes (HP:0001922)2.14367987
102Plantar hyperkeratosis (HP:0007556)2.13994782
103Pancreatic fibrosis (HP:0100732)2.12310812
104Abnormality of the axillary hair (HP:0100134)2.11811694
105Abnormality of secondary sexual hair (HP:0009888)2.11811694
106Subcapsular cataract (HP:0000523)2.10990437
107Enlarged epiphyses (HP:0010580)2.10413922
108Facial shape deformation (HP:0011334)2.10362017
109Potter facies (HP:0002009)2.10362017
110Poor head control (HP:0002421)2.10289013
111Premature loss of primary teeth (HP:0006323)2.09596245
112Bone pain (HP:0002653)2.09122756
113Metaphyseal dysplasia (HP:0100255)2.08457365
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08248358
115Keratoconjunctivitis sicca (HP:0001097)2.07531542
116Neuronal loss in central nervous system (HP:0002529)2.07188205
117Thin bony cortex (HP:0002753)2.05521445
118Nausea (HP:0002018)2.05445449
119Petechiae (HP:0000967)2.04510057
120Tetraparesis (HP:0002273)2.02498852
121Overgrowth (HP:0001548)2.01241823
122Parakeratosis (HP:0001036)2.00935700
123Glucose intolerance (HP:0000833)2.00825268
124Azoospermia (HP:0000027)2.00327817
125Progressive neurologic deterioration (HP:0002344)1.98945158
126Skin nodule (HP:0200036)1.98433294
127Tubulointerstitial abnormality (HP:0001969)1.98104779
128Aortic aneurysm (HP:0004942)1.97903639
129Erythroderma (HP:0001019)1.97669439
130Chromsome breakage (HP:0040012)1.97521703
131Male infertility (HP:0003251)1.95729969
132Abnormality of macrophages (HP:0004311)1.95541643
133Purpura (HP:0000979)1.94556547
134Steatorrhea (HP:0002570)1.93380484
135Abnormality of nucleobase metabolism (HP:0010932)1.92978417
136Asymmetric septal hypertrophy (HP:0001670)1.92681365
137Axonal loss (HP:0003447)1.91989753
138Abnormal trabecular bone morphology (HP:0100671)1.91976651
139Generalized aminoaciduria (HP:0002909)1.90447330
140Prostate neoplasm (HP:0100787)1.90443677
141Congenital, generalized hypertrichosis (HP:0004540)1.90005651
142Osteomyelitis (HP:0002754)1.89602450
143Upper motor neuron abnormality (HP:0002127)1.88327822
144Cerebral inclusion bodies (HP:0100314)1.88218011
145Corneal erosion (HP:0200020)1.87361157
146Thoracic kyphosis (HP:0002942)1.86452483
147Abnormality of dental color (HP:0011073)1.85353245
148Myositis (HP:0100614)1.84464215
149Abnormal glucose tolerance (HP:0001952)1.84407921
150Keratoconjunctivitis (HP:0001096)1.82703776
151Hypohidrosis (HP:0000966)1.81647273
152Aplasia/hypoplasia of the uterus (HP:0008684)1.81418954
153Mediastinal lymphadenopathy (HP:0100721)1.81405916
154Urticaria (HP:0001025)1.80713070
155Dementia (HP:0000726)1.80575633
156Neoplasm of the lung (HP:0100526)1.80361921
157Esophageal varix (HP:0002040)1.80351608
158Gingivitis (HP:0000230)1.79718973
159Abnormality of molar morphology (HP:0011070)1.79290189
160Abnormality of molar (HP:0011077)1.79290189
161Symptomatic seizures (HP:0011145)1.79178722
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.78985206
163Hypergonadotropic hypogonadism (HP:0000815)1.78580933
164Agnosia (HP:0010524)1.78504903
165Abnormality of iron homeostasis (HP:0011031)1.77543696
166Periodontitis (HP:0000704)1.77318555
167Intrahepatic cholestasis (HP:0001406)1.76732752
168Oral leukoplakia (HP:0002745)1.76137236
169Aneurysm (HP:0002617)1.74869882
170Nephropathy (HP:0000112)1.74728738
171Hypophosphatemia (HP:0002148)1.74596879
172Long foot (HP:0001833)1.73763902
173Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73037659
174Abnormality of alanine metabolism (HP:0010916)1.73037659
175Hyperalaninemia (HP:0003348)1.73037659
176Cone-rod dystrophy (HP:0000548)1.71497649
177Hypotrichosis (HP:0001006)1.70990432
178Nasolacrimal duct obstruction (HP:0000579)1.70401871
179Congenital sensorineural hearing impairment (HP:0008527)1.69442141
180Conical tooth (HP:0000698)1.67008571
181Absent eyebrow (HP:0002223)1.66246871
182Abdominal distention (HP:0003270)1.66204396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK7.26452268
2MAP3K135.20010735
3SIK14.77739786
4EPHA24.33273275
5CAMK1D4.00884693
6IRAK33.61623598
7LATS12.89657799
8CAMK1G2.87137173
9TTK2.53242796
10BLK2.51785215
11STK242.47985324
12NME22.18264584
13STK38L2.08849051
14EPHA32.06865434
15PIK3CA2.01648099
16PBK2.01348443
17TESK21.90030591
18GRK71.86055095
19MATK1.86016739
20ACVR1B1.76348383
21TAOK31.65893052
22FGR1.58923608
23IRAK41.44901334
24FRK1.44557878
25RIPK41.38219639
26EIF2AK21.37588196
27ABL21.37575508
28PRKG21.33402117
29STK101.31511025
30MAP3K91.29169223
31MAP3K61.22643887
32IRAK11.21619183
33PDK21.18729998
34TYK21.17285007
35MAP3K141.17088487
36FER1.15569224
37PRKAA21.13612872
38MYLK1.13355492
39STK161.12450849
40NUAK11.11204214
41TXK1.09431044
42PRKCH1.09325576
43TRPM71.08332363
44STK31.05219649
45EPHB11.04252667
46MOS1.01733677
47AKT31.01662221
48STK381.00085347
49ARAF0.99514597
50MAP2K30.98420793
51MAPK70.98318079
52KIT0.96456759
53NLK0.96378428
54CHUK0.96277733
55PDK40.94633606
56PDK30.94633606
57CDC42BPA0.94150870
58TAOK20.93286951
59TGFBR20.92832138
60MAPK120.92721012
61LATS20.92399813
62TIE10.90542129
63MAP3K20.90028174
64NEK60.89012300
65RIPK10.88803886
66LIMK10.88223566
67MAP3K10.87441123
68MARK30.86610681
69PTK60.85930662
70RPS6KB20.85853023
71PRPF4B0.85411896
72ZAP700.83625607
73PDPK10.83373288
74INSRR0.82095471
75EEF2K0.80987138
76JAK30.80079219
77MAP3K50.79606981
78FES0.78288017
79PIK3CG0.74876783
80PLK30.74367417
81CASK0.73932638
82PDGFRB0.72951902
83MST40.72652247
84ADRBK20.72195242
85MAP3K70.71894342
86CAMK10.70321050
87BCKDK0.68117140
88MAP3K80.67931953
89TAOK10.67873194
90TGFBR10.66621091
91MET0.65081002
92JAK10.64680483
93LMTK20.64424390
94PAK40.63546014
95FGFR40.62395502
96NEK90.56401684
97PRKCQ0.55854636
98TBK10.55696004
99MST1R0.55569401
100SGK20.55452477
101DMPK0.55215066
102MAPKAPK30.55182302
103SGK2230.54890757
104SGK4940.54890757
105PDK10.53679297
106MAP2K60.51476337
107CSK0.51290801
108ICK0.51236395
109PRKCE0.50834948
110PKN20.50084554
111GRK10.47963426
112CDK30.47003365
113SIK30.46870484
114TTN0.46415832
115LYN0.46393465
116SYK0.43859183
117STK390.43314721
118MELK0.41795186
119TNK20.41153418
120IKBKE0.40922572
121RPS6KC10.40193505
122RPS6KL10.40193505
123PTK20.39780932
124EGFR0.39523670
125CAMKK20.39343932
126ABL10.39260775
127PIM10.38512869
128MAP3K30.38266401
129PIM20.38098462
130MAPKAPK20.36817390
131MAPK150.36603375
132MAP3K110.36543709
133TNIK0.35723205
134CDK60.35411711
135PRKAA10.34556506
136DDR20.34344920
137CSNK1A10.34329953
138KSR20.34194705
139FGFR30.33595125
140EIF2AK30.33553382
141PLK40.32488795
142IRAK20.32446930
143PRKCD0.32143738
144BMPR1B0.31495871
145IGF1R0.30959430
146GSK3A0.30504832
147SGK30.29674411
148WNK40.29262110
149RPS6KA20.28893132
150ERBB30.28578177
151MAPKAPK50.27815068
152IKBKB0.27734528
153NME10.26944805
154BMPR20.26813714
155MKNK20.26181887
156CHEK20.24553760
157TEC0.24258935
158RPS6KB10.22796561

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000619.13310097
2Caffeine metabolism_Homo sapiens_hsa002327.40712032
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.97798985
4Galactose metabolism_Homo sapiens_hsa000522.89608854
5Staphylococcus aureus infection_Homo sapiens_hsa051502.39828200
6Vitamin B6 metabolism_Homo sapiens_hsa007502.22621408
7Osteoclast differentiation_Homo sapiens_hsa043801.98570989
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.73731488
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64044243
10Vitamin digestion and absorption_Homo sapiens_hsa049771.63314624
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61178527
12Prolactin signaling pathway_Homo sapiens_hsa049171.58711317
13Fatty acid metabolism_Homo sapiens_hsa012121.56671246
14Asthma_Homo sapiens_hsa053101.52748470
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.50853907
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.45028959
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.44839279
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32837080
19Propanoate metabolism_Homo sapiens_hsa006401.31324455
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27174758
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26150409
22N-Glycan biosynthesis_Homo sapiens_hsa005101.22446584
23Pertussis_Homo sapiens_hsa051331.21119073
24Rheumatoid arthritis_Homo sapiens_hsa053231.10495567
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09095515
26Fructose and mannose metabolism_Homo sapiens_hsa000511.09014311
27Mineral absorption_Homo sapiens_hsa049781.06810116
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.05564349
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03934204
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03480409
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03371844
32Synaptic vesicle cycle_Homo sapiens_hsa047211.03161983
33Sulfur metabolism_Homo sapiens_hsa009201.02535852
34NF-kappa B signaling pathway_Homo sapiens_hsa040640.99292641
35Arachidonic acid metabolism_Homo sapiens_hsa005900.96724355
36Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95687791
37p53 signaling pathway_Homo sapiens_hsa041150.95633377
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95234834
39Dorso-ventral axis formation_Homo sapiens_hsa043200.93291669
40ECM-receptor interaction_Homo sapiens_hsa045120.91118065
41Chemokine signaling pathway_Homo sapiens_hsa040620.90449078
42B cell receptor signaling pathway_Homo sapiens_hsa046620.89273455
43Salmonella infection_Homo sapiens_hsa051320.88166471
44Steroid biosynthesis_Homo sapiens_hsa001000.86687194
45Ether lipid metabolism_Homo sapiens_hsa005650.84400571
46Hematopoietic cell lineage_Homo sapiens_hsa046400.83269886
47Protein export_Homo sapiens_hsa030600.78991553
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78233167
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77695235
50Lysosome_Homo sapiens_hsa041420.77673261
51Protein digestion and absorption_Homo sapiens_hsa049740.77529193
52Regulation of autophagy_Homo sapiens_hsa041400.76591073
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75869078
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75083578
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74680725
56Ovarian steroidogenesis_Homo sapiens_hsa049130.74652958
57Fatty acid elongation_Homo sapiens_hsa000620.74193289
58beta-Alanine metabolism_Homo sapiens_hsa004100.73788691
59Fat digestion and absorption_Homo sapiens_hsa049750.73546539
60Small cell lung cancer_Homo sapiens_hsa052220.72575259
61Pyruvate metabolism_Homo sapiens_hsa006200.72048646
62ABC transporters_Homo sapiens_hsa020100.71199507
63Sphingolipid metabolism_Homo sapiens_hsa006000.71183373
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70643472
65Shigellosis_Homo sapiens_hsa051310.70569208
66Autoimmune thyroid disease_Homo sapiens_hsa053200.69609411
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69262315
68Toxoplasmosis_Homo sapiens_hsa051450.65280776
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64561861
70Antigen processing and presentation_Homo sapiens_hsa046120.64545031
71Amoebiasis_Homo sapiens_hsa051460.64359325
72Complement and coagulation cascades_Homo sapiens_hsa046100.64243633
73PPAR signaling pathway_Homo sapiens_hsa033200.64101056
74Acute myeloid leukemia_Homo sapiens_hsa052210.63702474
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.61755084
76Hippo signaling pathway_Homo sapiens_hsa043900.59772975
77Adherens junction_Homo sapiens_hsa045200.59771216
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58786775
79Bladder cancer_Homo sapiens_hsa052190.57858655
80Other glycan degradation_Homo sapiens_hsa005110.56802473
81Endocytosis_Homo sapiens_hsa041440.56360827
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55964242
83Hepatitis C_Homo sapiens_hsa051600.55915542
84Circadian rhythm_Homo sapiens_hsa047100.55884493
85Viral myocarditis_Homo sapiens_hsa054160.55594640
86Collecting duct acid secretion_Homo sapiens_hsa049660.54355491
87Measles_Homo sapiens_hsa051620.52681739
88Basal cell carcinoma_Homo sapiens_hsa052170.52296217
89Renin-angiotensin system_Homo sapiens_hsa046140.52215166
90Platelet activation_Homo sapiens_hsa046110.51681870
91Vibrio cholerae infection_Homo sapiens_hsa051100.50772825
92Tryptophan metabolism_Homo sapiens_hsa003800.49856608
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48951950
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48420713
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48331670
96Legionellosis_Homo sapiens_hsa051340.47448989
97Leishmaniasis_Homo sapiens_hsa051400.46689757
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46669891
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.46283417
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46261668
101FoxO signaling pathway_Homo sapiens_hsa040680.45399629
102TNF signaling pathway_Homo sapiens_hsa046680.45269251
103Pancreatic secretion_Homo sapiens_hsa049720.44777465
104Tight junction_Homo sapiens_hsa045300.44708848
105Tuberculosis_Homo sapiens_hsa051520.42064565
106Pentose phosphate pathway_Homo sapiens_hsa000300.41507619
107Glycerolipid metabolism_Homo sapiens_hsa005610.41454242
108Herpes simplex infection_Homo sapiens_hsa051680.41329414
109Influenza A_Homo sapiens_hsa051640.40605806
110Phagosome_Homo sapiens_hsa041450.40482598
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39439866
112Renal cell carcinoma_Homo sapiens_hsa052110.39048474
113Glutathione metabolism_Homo sapiens_hsa004800.38922023
114Malaria_Homo sapiens_hsa051440.37007556
115Pancreatic cancer_Homo sapiens_hsa052120.36906191
116HIF-1 signaling pathway_Homo sapiens_hsa040660.36035607
117Histidine metabolism_Homo sapiens_hsa003400.35032051
118Bile secretion_Homo sapiens_hsa049760.34795023
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34094445
120GnRH signaling pathway_Homo sapiens_hsa049120.33786349
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.33476020
122Notch signaling pathway_Homo sapiens_hsa043300.33181752
123Fanconi anemia pathway_Homo sapiens_hsa034600.32286837
124Type I diabetes mellitus_Homo sapiens_hsa049400.31984366
125Folate biosynthesis_Homo sapiens_hsa007900.31170347
126Apoptosis_Homo sapiens_hsa042100.30943928
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30893556
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30502114
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30340040
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.30052261
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.29538676
132Peroxisome_Homo sapiens_hsa041460.29264267
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29178557
134Metabolic pathways_Homo sapiens_hsa011000.28730344
135Graft-versus-host disease_Homo sapiens_hsa053320.28278374
136VEGF signaling pathway_Homo sapiens_hsa043700.28025462
137Starch and sucrose metabolism_Homo sapiens_hsa005000.27945017
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27795790
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.27385681
140Retinol metabolism_Homo sapiens_hsa008300.26819033
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26473165
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.26152438
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25971256
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24598889
145Taste transduction_Homo sapiens_hsa047420.24046997
146Type II diabetes mellitus_Homo sapiens_hsa049300.23623183
147Hepatitis B_Homo sapiens_hsa051610.22937445
148Allograft rejection_Homo sapiens_hsa053300.22859494
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.22075914

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