SLC29A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.16485510
2L-phenylalanine catabolic process (GO:0006559)5.77879430
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.77879430
4L-phenylalanine metabolic process (GO:0006558)5.77599935
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.77599935
6establishment of integrated proviral latency (GO:0075713)5.69105804
7DNA strand elongation involved in DNA replication (GO:0006271)5.46832975
8DNA strand elongation (GO:0022616)5.29857225
9aromatic amino acid family catabolic process (GO:0009074)5.16594231
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96829790
11protein maturation by protein folding (GO:0022417)4.89778217
12negative regulation of fibrinolysis (GO:0051918)4.84548302
13kynurenine metabolic process (GO:0070189)4.84521533
14glycine metabolic process (GO:0006544)4.75112876
15telomere maintenance via semi-conservative replication (GO:0032201)4.74347367
16protein carboxylation (GO:0018214)4.72408663
17peptidyl-glutamic acid carboxylation (GO:0017187)4.72408663
18indolalkylamine catabolic process (GO:0046218)4.66686904
19tryptophan catabolic process (GO:0006569)4.66686904
20indole-containing compound catabolic process (GO:0042436)4.66686904
21alpha-linolenic acid metabolic process (GO:0036109)4.63795222
22glyoxylate metabolic process (GO:0046487)4.60814997
23establishment of viral latency (GO:0019043)4.55496334
24high-density lipoprotein particle remodeling (GO:0034375)4.54468446
25bile acid biosynthetic process (GO:0006699)4.51290564
26urea cycle (GO:0000050)4.46679781
27urea metabolic process (GO:0019627)4.46679781
28tryptophan metabolic process (GO:0006568)4.41902846
29sulfur amino acid catabolic process (GO:0000098)4.41056248
30regulation of fibrinolysis (GO:0051917)4.40138752
31regulation of protein activation cascade (GO:2000257)4.38082168
32mitotic chromosome condensation (GO:0007076)4.37079719
33DNA replication initiation (GO:0006270)4.29901710
34cysteine metabolic process (GO:0006534)4.25856203
35lysine catabolic process (GO:0006554)4.25538239
36lysine metabolic process (GO:0006553)4.25538239
37serine family amino acid catabolic process (GO:0009071)4.25282923
38complement activation, alternative pathway (GO:0006957)4.16353963
39serine family amino acid biosynthetic process (GO:0009070)4.13300299
40regulation of complement activation (GO:0030449)4.12078610
41nitrogen cycle metabolic process (GO:0071941)4.07453050
42serine family amino acid metabolic process (GO:0009069)3.93311560
43negative regulation of cholesterol transport (GO:0032375)3.92894875
44negative regulation of sterol transport (GO:0032372)3.92894875
45imidazole-containing compound metabolic process (GO:0052803)3.92793928
46folic acid-containing compound biosynthetic process (GO:0009396)3.90159270
47regulation of cholesterol esterification (GO:0010872)3.89748162
48IMP biosynthetic process (GO:0006188)3.88636680
49heterochromatin organization (GO:0070828)3.86415033
50homocysteine metabolic process (GO:0050667)3.86075371
51reverse cholesterol transport (GO:0043691)3.83922721
52bile acid metabolic process (GO:0008206)3.79583784
53IMP metabolic process (GO:0046040)3.78388776
54aromatic amino acid family metabolic process (GO:0009072)3.77451587
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.76891729
56triglyceride homeostasis (GO:0070328)3.75935055
57acylglycerol homeostasis (GO:0055090)3.75935055
58tetrahydrofolate metabolic process (GO:0046653)3.75913228
59telomere maintenance via recombination (GO:0000722)3.73650744
60protein-lipid complex remodeling (GO:0034368)3.72806587
61macromolecular complex remodeling (GO:0034367)3.72806587
62plasma lipoprotein particle remodeling (GO:0034369)3.72806587
63regulation of triglyceride catabolic process (GO:0010896)3.71635328
64amino-acid betaine metabolic process (GO:0006577)3.71445024
65alpha-amino acid catabolic process (GO:1901606)3.69712132
66plasma lipoprotein particle clearance (GO:0034381)3.68116213
67one-carbon metabolic process (GO:0006730)3.64308341
68phospholipid efflux (GO:0033700)3.62295723
69proline biosynthetic process (GO:0006561)3.61832638
70tyrosine metabolic process (GO:0006570)3.60062090
71regulation of cholesterol homeostasis (GO:2000188)3.59961750
72protein localization to chromosome, centromeric region (GO:0071459)3.57185035
73regulation of translational fidelity (GO:0006450)3.57030943
74ethanol oxidation (GO:0006069)3.55878918
75L-serine metabolic process (GO:0006563)3.55441257
76nuclear pore complex assembly (GO:0051292)3.54065142
77protein localization to kinetochore (GO:0034501)3.53555867
78mitotic sister chromatid segregation (GO:0000070)3.53287645
79mitotic recombination (GO:0006312)3.49789524
80mitotic nuclear envelope disassembly (GO:0007077)3.44571768
81fibrinolysis (GO:0042730)3.41335517
82folic acid metabolic process (GO:0046655)3.40187163
83cellular modified amino acid catabolic process (GO:0042219)3.37624756
84cellular amino acid catabolic process (GO:0009063)3.37501572
85DNA replication checkpoint (GO:0000076)3.36506859
86mitotic metaphase plate congression (GO:0007080)3.35714281
87negative regulation of fatty acid biosynthetic process (GO:0045717)3.34695758
88formation of translation preinitiation complex (GO:0001731)3.34670690
89NADH metabolic process (GO:0006734)3.33914458
90protein complex localization (GO:0031503)3.32982793
91pentose-phosphate shunt (GO:0006098)3.32565020
92cellular glucuronidation (GO:0052695)3.32054278
93benzene-containing compound metabolic process (GO:0042537)3.31427796
94coenzyme catabolic process (GO:0009109)3.30940993
95bile acid and bile salt transport (GO:0015721)3.30902826
96positive regulation of triglyceride lipase activity (GO:0061365)3.29782820
97positive regulation of lipoprotein lipase activity (GO:0051006)3.29782820
98blood coagulation, intrinsic pathway (GO:0007597)3.29634480
99aldehyde catabolic process (GO:0046185)3.27232029
1002-oxoglutarate metabolic process (GO:0006103)3.24263781
101plasma lipoprotein particle assembly (GO:0034377)3.24195521
102peptidyl-arginine omega-N-methylation (GO:0035247)3.23203687
103valine metabolic process (GO:0006573)3.19831998
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19324025
105NADPH regeneration (GO:0006740)3.18890239
106indolalkylamine metabolic process (GO:0006586)3.18843877
107membrane disassembly (GO:0030397)3.15773289
108nuclear envelope disassembly (GO:0051081)3.15773289
109telomere maintenance via telomere lengthening (GO:0010833)3.14493348
110nucleobase biosynthetic process (GO:0046112)3.13763076
111base-excision repair (GO:0006284)3.12894706
112folic acid-containing compound metabolic process (GO:0006760)3.12590364
113cofactor catabolic process (GO:0051187)3.11939824
114epoxygenase P450 pathway (GO:0019373)3.11838722
115cholesterol efflux (GO:0033344)3.10638048
116sister chromatid segregation (GO:0000819)3.09227667
117purine nucleobase biosynthetic process (GO:0009113)3.09218377
118ribosome assembly (GO:0042255)3.08864617
119dicarboxylic acid biosynthetic process (GO:0043650)3.07947671
120nuclear pore organization (GO:0006999)3.07564235
121histone arginine methylation (GO:0034969)3.06884254
122cholesterol homeostasis (GO:0042632)3.06434059
1234-hydroxyproline metabolic process (GO:0019471)3.06326964
124arginine metabolic process (GO:0006525)3.05856815
125positive regulation of triglyceride metabolic process (GO:0090208)3.04737925
126COPI coating of Golgi vesicle (GO:0048205)3.03478881
127Golgi transport vesicle coating (GO:0048200)3.03478881
128cellular biogenic amine catabolic process (GO:0042402)3.03180486
129amine catabolic process (GO:0009310)3.03180486
130regulation of plasminogen activation (GO:0010755)3.01179129
131glutamate metabolic process (GO:0006536)3.01092937
132regulation of mitochondrial translation (GO:0070129)3.00714601
133sterol homeostasis (GO:0055092)3.00043705
134mitotic nuclear envelope reassembly (GO:0007084)2.99963085
135nuclear envelope reassembly (GO:0031468)2.99963085
136cellular ketone body metabolic process (GO:0046950)2.99961403
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.99935374
138response to nitrosative stress (GO:0051409)2.99017133
139low-density lipoprotein particle remodeling (GO:0034374)2.97336934
140lipoprotein metabolic process (GO:0042157)2.97134836
141protein activation cascade (GO:0072376)2.96956292
142phospholipid homeostasis (GO:0055091)2.96569402
143acetyl-CoA metabolic process (GO:0006084)2.96063170
144protein-lipid complex assembly (GO:0065005)2.96052074
145glucose catabolic process (GO:0006007)2.95329429
146pteridine-containing compound biosynthetic process (GO:0042559)2.94721287
147cellular protein complex localization (GO:0034629)2.94601157
148complement activation, classical pathway (GO:0006958)2.93618049
149regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90513789
150positive regulation of DNA-dependent DNA replication (GO:2000105)2.87818380
151tricarboxylic acid cycle (GO:0006099)2.87261690
152protoporphyrinogen IX metabolic process (GO:0046501)2.85622168
153DNA duplex unwinding (GO:0032508)2.82202100
154nucleobase-containing small molecule interconversion (GO:0015949)2.81611876
155regulation of spindle organization (GO:0090224)2.80792352
156chromosome condensation (GO:0030261)2.78623321
157glycolytic process (GO:0006096)2.76131818
158metaphase plate congression (GO:0051310)2.75428737
159positive regulation of chromosome segregation (GO:0051984)2.74961413
160L-alpha-amino acid transmembrane transport (GO:1902475)2.74861081
161protoporphyrinogen IX biosynthetic process (GO:0006782)2.74571986
162regulation of mitotic spindle organization (GO:0060236)2.74098417
163proline metabolic process (GO:0006560)2.67982731
164pore complex assembly (GO:0046931)2.67219662
165gluconeogenesis (GO:0006094)2.66880252
166DNA geometric change (GO:0032392)2.66711840
167heme biosynthetic process (GO:0006783)2.65941625
168negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63152392
169protein retention in ER lumen (GO:0006621)2.63063918
170tRNA aminoacylation for protein translation (GO:0006418)2.62929941
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59929292
172monosaccharide biosynthetic process (GO:0046364)2.58868018
173oxaloacetate metabolic process (GO:0006107)2.58442141
174transcription-coupled nucleotide-excision repair (GO:0006283)2.57485176
175CENP-A containing nucleosome assembly (GO:0034080)2.56618971
176anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.55739757
177negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55447817
178DNA conformation change (GO:0071103)2.54947093
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54582875
180nuclear envelope organization (GO:0006998)2.54024756
181peptidyl-arginine methylation (GO:0018216)2.53523118
182peptidyl-arginine N-methylation (GO:0035246)2.53523118
183regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53521102
184hexose biosynthetic process (GO:0019319)2.52676228
185oxidative phosphorylation (GO:0006119)2.51124178
186ribosome biogenesis (GO:0042254)2.51021542
187amino acid activation (GO:0043038)2.50528866
188tRNA aminoacylation (GO:0043039)2.50528866
189proteasome assembly (GO:0043248)2.49921386
190negative regulation of chromosome segregation (GO:0051985)2.49646680
191DNA topological change (GO:0006265)2.48750604
192regulation of translational termination (GO:0006449)2.48254625
193chromatin remodeling at centromere (GO:0031055)2.47472196
194regulation of chromosome segregation (GO:0051983)2.47049097
195porphyrin-containing compound biosynthetic process (GO:0006779)2.46828007
196negative regulation of ligase activity (GO:0051352)2.45845758
197negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.45845758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.18392926
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.89338160
3E2F7_22180533_ChIP-Seq_HELA_Human4.80518316
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.48770714
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.79503288
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.75220094
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.56179556
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.38113246
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.09144210
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.96111018
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69215735
12* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.62221968
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.60436787
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.29824747
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28074619
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.12906819
17FOXM1_23109430_ChIP-Seq_U2OS_Human1.98997548
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91758510
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87580872
20CLOCK_20551151_ChIP-Seq_293T_Human1.84183902
21ZNF263_19887448_ChIP-Seq_K562_Human1.78570974
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74786442
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72128280
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71594994
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66994478
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64834208
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63740481
28* MYC_22102868_ChIP-Seq_BL_Human1.58007109
29GATA1_22025678_ChIP-Seq_K562_Human1.57898364
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57638240
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52113904
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51680292
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47003585
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.46984074
35TTF2_22483619_ChIP-Seq_HELA_Human1.46736131
36* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46161139
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.46156428
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44973864
39AR_21909140_ChIP-Seq_LNCAP_Human1.44374091
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42776413
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41090254
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41067076
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40396559
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.40174536
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38715771
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37448558
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34837981
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.33313737
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28733611
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25162525
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.23584731
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22350829
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21147007
54TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20291749
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17818749
56XRN2_22483619_ChIP-Seq_HELA_Human1.17630976
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17604313
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14147246
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.12112828
60* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10990675
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10723965
62VDR_21846776_ChIP-Seq_THP-1_Human1.08380702
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08209981
64* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06499897
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05479138
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04885433
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04801755
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04752042
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.04502451
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04142043
71* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04115845
72TFEB_21752829_ChIP-Seq_HELA_Human1.03690017
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03225949
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03176162
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02969868
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02663498
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02588384
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01994075
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01828292
80KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00867229
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99822329
82E2F1_21310950_ChIP-Seq_MCF-7_Human0.99449312
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99331878
84* LXR_22292898_ChIP-Seq_THP-1_Human0.98828807
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98014901
86* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97886872
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.97533617
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96330508
89DCP1A_22483619_ChIP-Seq_HELA_Human0.93974348
90* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93519776
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.93481437
92TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93306528
93HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92925018
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91975324
95ATF3_27146783_Chip-Seq_COLON_Human0.91932178
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91792175
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91672365
98EST1_17652178_ChIP-ChIP_JURKAT_Human0.91131544
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90783404
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90488120
101TP63_17297297_ChIP-ChIP_HaCaT_Human0.90222250
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89648225
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89276069
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88418477
105* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88061906
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85808438
107* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85780786
108MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85256052
109* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85200472
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85149084
111FOXP3_21729870_ChIP-Seq_TREG_Human0.84869804
112GABP_19822575_ChIP-Seq_HepG2_Human0.83460306
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82753595
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.81719408
115* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81373074
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.81014648
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80975176
118* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80743548
119MAF_26560356_Chip-Seq_TH1_Human0.80465396
120KDM5A_27292631_Chip-Seq_BREAST_Human0.80391291
121* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79412815
122RACK7_27058665_Chip-Seq_MCF-7_Human0.79021964
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78699466
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77762349
125* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76937726
126* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.76620222
127* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.76614009
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75861390
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75841950
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75819297
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75794074
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75048119
133* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74411159
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74356229
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.74224059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.15042104
2MP0005360_urolithiasis5.87198733
3MP0005085_abnormal_gallbladder_physiolo4.69037546
4MP0005365_abnormal_bile_salt4.47252683
5MP0003806_abnormal_nucleotide_metabolis4.44405255
6MP0008875_abnormal_xenobiotic_pharmacok3.49112798
7MP0009840_abnormal_foam_cell3.22053309
8MP0003705_abnormal_hypodermis_morpholog3.01452347
9MP0003252_abnormal_bile_duct2.91056755
10MP0000751_myopathy2.87432779
11MP0010329_abnormal_lipoprotein_level2.66462725
12MP0010030_abnormal_orbit_morphology2.59624797
13MP0005083_abnormal_biliary_tract2.47894492
14MP0008932_abnormal_embryonic_tissue2.46776855
15MP0003191_abnormal_cellular_cholesterol2.36011280
16MP0003195_calcinosis2.34875879
17MP0008058_abnormal_DNA_repair2.23632802
18MP0004233_abnormal_muscle_weight2.13680883
19MP0000749_muscle_degeneration1.97694249
20MP0000609_abnormal_liver_physiology1.95709395
21MP0005332_abnormal_amino_acid1.95600268
22MP0008057_abnormal_DNA_replication1.82381389
23MP0004185_abnormal_adipocyte_glucose1.79428432
24MP0003718_maternal_effect1.75997731
25MP0005319_abnormal_enzyme/_coenzyme1.70653514
26MP0001666_abnormal_nutrient_absorption1.66851040
27MP0001661_extended_life_span1.65907302
28MP0008438_abnormal_cutaneous_collagen1.62146692
29MP0003656_abnormal_erythrocyte_physiolo1.61525575
30MP0003123_paternal_imprinting1.60581301
31MP0000350_abnormal_cell_proliferation1.60169405
32MP0004147_increased_porphyrin_level1.59235857
33MP0005380_embryogenesis_phenotype1.54689140
34MP0001672_abnormal_embryogenesis/_devel1.54689140
35MP0003984_embryonic_growth_retardation1.52123607
36MP0002080_prenatal_lethality1.51264006
37MP0010368_abnormal_lymphatic_system1.49251316
38MP0004087_abnormal_muscle_fiber1.49002180
39MP0000747_muscle_weakness1.48253982
40MP0002118_abnormal_lipid_homeostasis1.47244430
41MP0003950_abnormal_plasma_membrane1.47117907
42MP0005058_abnormal_lysosome_morphology1.43189759
43MP0003941_abnormal_skin_development1.43188296
44MP0002088_abnormal_embryonic_growth/wei1.41839571
45MP0002138_abnormal_hepatobiliary_system1.41553247
46MP0002796_impaired_skin_barrier1.40965736
47MP0003186_abnormal_redox_activity1.40885368
48MP0005257_abnormal_intraocular_pressure1.35481136
49MP0000750_abnormal_muscle_regeneration1.34767513
50MP0001764_abnormal_homeostasis1.33959624
51MP0004019_abnormal_vitamin_homeostasis1.33612621
52MP0010630_abnormal_cardiac_muscle1.32201405
53MP0001697_abnormal_embryo_size1.31851823
54MP0004084_abnormal_cardiac_muscle1.31735860
55MP0003786_premature_aging1.29351119
56MP0000598_abnormal_liver_morphology1.29231658
57MP0000003_abnormal_adipose_tissue1.25049979
58MP0005375_adipose_tissue_phenotype1.22057267
59MP0001849_ear_inflammation1.20990572
60MP0002106_abnormal_muscle_physiology1.18468524
61MP0000759_abnormal_skeletal_muscle1.16418902
62MP0006138_congestive_heart_failure1.16415633
63MP0010352_gastrointestinal_tract_polyps1.16332595
64MP0004036_abnormal_muscle_relaxation1.16195738
65MP0009643_abnormal_urine_homeostasis1.15820160
66MP0005023_abnormal_wound_healing1.14724310
67MP0002085_abnormal_embryonic_tissue1.14519154
68MP0006054_spinal_hemorrhage1.13761154
69MP0005501_abnormal_skin_physiology1.13013400
70MP0005584_abnormal_enzyme/coenzyme_acti1.12397860
71MP0000313_abnormal_cell_death1.09386412
72MP0009763_increased_sensitivity_to1.08122033
73MP0002254_reproductive_system_inflammat1.07348371
74MP0006035_abnormal_mitochondrial_morpho1.05717583
75MP0005670_abnormal_white_adipose1.02918270
76MP0008260_abnormal_autophagy1.01015672
77MP0003868_abnormal_feces_composition0.99507888
78MP0005369_muscle_phenotype0.97653088
79MP0003693_abnormal_embryo_hatching0.95182587
80MP0003724_increased_susceptibility_to0.94851087
81MP0004145_abnormal_muscle_electrophysio0.93098520
82MP0001243_abnormal_dermal_layer0.92312192
83MP0003566_abnormal_cell_adhesion0.92269243
84MP0001853_heart_inflammation0.91350405
85MP0003279_aneurysm0.90909158
86MP0005275_abnormal_skin_tensile0.90190819
87MP0003300_gastrointestinal_ulcer0.90123506
88MP0002084_abnormal_developmental_patter0.89010015
89MP0008469_abnormal_protein_level0.89006602
90MP0005165_increased_susceptibility_to0.88368909
91MP0002972_abnormal_cardiac_muscle0.88294985
92MP0006036_abnormal_mitochondrial_physio0.88160951
93MP0003315_abnormal_perineum_morphology0.87764268
94MP0000358_abnormal_cell_content/0.87425919
95MP0003436_decreased_susceptibility_to0.86855018
96MP0003567_abnormal_fetal_cardiomyocyte0.85540870
97MP0005266_abnormal_metabolism0.85400381
98MP0004957_abnormal_blastocyst_morpholog0.85220225
99MP0008775_abnormal_heart_ventricle0.85114538
100MP0009703_decreased_birth_body0.82441918
101MP0003221_abnormal_cardiomyocyte_apopto0.81579542
102MP0002060_abnormal_skin_morphology0.81522566
103MP0005376_homeostasis/metabolism_phenot0.79925413
104MP0005397_hematopoietic_system_phenotyp0.79090558
105MP0001545_abnormal_hematopoietic_system0.79090558
106MP0002396_abnormal_hematopoietic_system0.79016236
107MP0002877_abnormal_melanocyte_morpholog0.78560227
108MP0009764_decreased_sensitivity_to0.77842648
109MP0001727_abnormal_embryo_implantation0.75692873
110MP0005636_abnormal_mineral_homeostasis0.74827522
111MP0005384_cellular_phenotype0.73716037
112MP0005621_abnormal_cell_physiology0.73674571
113MP0003111_abnormal_nucleus_morphology0.72207903
114MP0005220_abnormal_exocrine_pancreas0.72166346
115MP0010094_abnormal_chromosome_stability0.71468888
116MP0009642_abnormal_blood_homeostasis0.70854396
117MP0000678_abnormal_parathyroid_gland0.70107504
118MP0005647_abnormal_sex_gland0.69640334
119MP0005464_abnormal_platelet_physiology0.69466233
120MP0002269_muscular_atrophy0.69253330
121MP0000266_abnormal_heart_morphology0.68108856
122MP0001915_intracranial_hemorrhage0.66872486
123MP0009697_abnormal_copulation0.66761446
124MP0000858_altered_metastatic_potential0.65893794
125MP0010307_abnormal_tumor_latency0.65882687
126MP0002697_abnormal_eye_size0.65460832
127MP0001542_abnormal_bone_strength0.64609059
128MP0000537_abnormal_urethra_morphology0.64365642
129MP0000685_abnormal_immune_system0.62806392
130MP0003077_abnormal_cell_cycle0.60625025
131MP0003011_delayed_dark_adaptation0.60202882
132MP0002970_abnormal_white_adipose0.59962895
133MP0005503_abnormal_tendon_morphology0.59396652
134MP0009765_abnormal_xenobiotic_induced0.57920868
135MP0002078_abnormal_glucose_homeostasis0.57346671
136MP0005408_hypopigmentation0.57214902
137MP0001730_embryonic_growth_arrest0.56727934
138MP0005451_abnormal_body_composition0.56278415
139MP0001533_abnormal_skeleton_physiology0.55596956
140MP0008007_abnormal_cellular_replicative0.55494957
141MP0004272_abnormal_basement_membrane0.55317499
142MP0009053_abnormal_anal_canal0.55083397
143MP0002019_abnormal_tumor_incidence0.54982840
144MP0005076_abnormal_cell_differentiation0.54882921
145MP0008873_increased_physiological_sensi0.54693513
146MP0005666_abnormal_adipose_tissue0.54672748
147MP0000604_amyloidosis0.54221501
148MP0001881_abnormal_mammary_gland0.53639247
149MP0009278_abnormal_bone_marrow0.53085273
150MP0004130_abnormal_muscle_cell0.52537272
151MP0001756_abnormal_urination0.52062151
152MP0002971_abnormal_brown_adipose0.52022151
153MP0002086_abnormal_extraembryonic_tissu0.51025429
154MP0000249_abnormal_blood_vessel0.50276565
155MP0005330_cardiomyopathy0.49776581
156MP0004947_skin_inflammation0.48576306
157MP0002933_joint_inflammation0.48366138
158MP0004197_abnormal_fetal_growth/weight/0.48072547
159MP0002136_abnormal_kidney_physiology0.47876363
160MP0009672_abnormal_birth_weight0.47623669

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.09300263
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.92273341
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.76894539
4Intrahepatic cholestasis (HP:0001406)5.73350845
5Hypobetalipoproteinemia (HP:0003563)5.13588661
6Xanthomatosis (HP:0000991)5.09948789
7Prolonged partial thromboplastin time (HP:0003645)4.78526224
8Hyperlipoproteinemia (HP:0010980)4.03315417
9Complement deficiency (HP:0004431)4.02146162
10Hypolipoproteinemia (HP:0010981)3.96722683
11Abnormality of pyrimidine metabolism (HP:0004353)3.91186758
12Hypoglycemic coma (HP:0001325)3.81201200
13Abnormality of the common coagulation pathway (HP:0010990)3.77399065
14Hyperammonemia (HP:0001987)3.76059177
15Joint hemorrhage (HP:0005261)3.58224591
16Hypoalphalipoproteinemia (HP:0003233)3.55437979
17Abnormality of the intrinsic pathway (HP:0010989)3.54117214
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.52226381
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.42377778
20Abnormality of glycolysis (HP:0004366)3.41204861
21Progressive muscle weakness (HP:0003323)3.38055492
22Abnormality of methionine metabolism (HP:0010901)3.33189198
23Ketosis (HP:0001946)3.32599273
24Abnormality of complement system (HP:0005339)3.32588358
25Epidermoid cyst (HP:0200040)3.27351071
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17270313
27Hyperglycinemia (HP:0002154)3.07914000
28Hyperbilirubinemia (HP:0002904)3.06702754
29Fat malabsorption (HP:0002630)3.02648066
30Increased serum pyruvate (HP:0003542)3.02225258
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99803100
32Hyperglycinuria (HP:0003108)2.91926903
33Hypercholesterolemia (HP:0003124)2.91060500
34Spastic diplegia (HP:0001264)2.90900673
35Distal lower limb muscle weakness (HP:0009053)2.87791734
36Centrally nucleated skeletal muscle fibers (HP:0003687)2.87559142
37Exercise-induced muscle cramps (HP:0003710)2.83852314
38Myocardial infarction (HP:0001658)2.81977025
39Abnormality of serine family amino acid metabolism (HP:0010894)2.81075768
40Abnormality of glycine metabolism (HP:0010895)2.81075768
41Hepatocellular carcinoma (HP:0001402)2.79095583
42Abnormality of nucleobase metabolism (HP:0010932)2.73700666
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71122537
44Microvesicular hepatic steatosis (HP:0001414)2.64835899
45Abnormality of fatty-acid metabolism (HP:0004359)2.63277437
46Trismus (HP:0000211)2.62250517
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.60006186
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59804207
49Ragged-red muscle fibers (HP:0003200)2.55835609
50Nemaline bodies (HP:0003798)2.55268381
51Protrusio acetabuli (HP:0003179)2.54226275
52Chromsome breakage (HP:0040012)2.51639832
53Abnormal cartilage morphology (HP:0002763)2.44745104
54Delayed CNS myelination (HP:0002188)2.43249034
55Nonimmune hydrops fetalis (HP:0001790)2.42666458
56Abnormality of iron homeostasis (HP:0011031)2.42520750
57Ketoacidosis (HP:0001993)2.42453840
58Cholelithiasis (HP:0001081)2.41870804
59Skin nodule (HP:0200036)2.41417581
60Abnormal gallbladder morphology (HP:0012437)2.38322821
61Myoglobinuria (HP:0002913)2.37496696
62Reticulocytosis (HP:0001923)2.33076975
63Steatorrhea (HP:0002570)2.29724063
64Rhabdomyolysis (HP:0003201)2.29657568
65Hypochromic microcytic anemia (HP:0004840)2.28577596
66Abnormality of transition element cation homeostasis (HP:0011030)2.27743883
67Reduced antithrombin III activity (HP:0001976)2.27206758
68Myopathic facies (HP:0002058)2.26615208
69Exercise-induced myalgia (HP:0003738)2.26253144
70Abnormality of serum amino acid levels (HP:0003112)2.25795835
71Distal lower limb amyotrophy (HP:0008944)2.25666561
72Selective tooth agenesis (HP:0001592)2.24247841
73Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24231241
74Birth length less than 3rd percentile (HP:0003561)2.24198554
75Poikilocytosis (HP:0004447)2.23540688
76Hypoglycemic seizures (HP:0002173)2.22532543
77Muscle fiber inclusion bodies (HP:0100299)2.19896390
78Mitral stenosis (HP:0001718)2.18517842
79Limb-girdle muscle atrophy (HP:0003797)2.17132812
80Esophageal varix (HP:0002040)2.16405918
81Increased serum ferritin (HP:0003281)2.15860270
82Muscle stiffness (HP:0003552)2.15652735
83Abnormality of purine metabolism (HP:0004352)2.14957620
84Testicular atrophy (HP:0000029)2.14580534
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13203245
86Dicarboxylic aciduria (HP:0003215)2.13203245
87Systemic lupus erythematosus (HP:0002725)2.13041660
88Type I transferrin isoform profile (HP:0003642)2.12226990
89Reticulocytopenia (HP:0001896)2.12060078
90Late onset (HP:0003584)2.10919601
91Right ventricular cardiomyopathy (HP:0011663)2.08800083
92High pitched voice (HP:0001620)2.07971100
93Microglossia (HP:0000171)2.06516029
94Vertebral compression fractures (HP:0002953)2.06339031
95Conjugated hyperbilirubinemia (HP:0002908)2.05952692
96Vascular calcification (HP:0004934)2.05731183
97Secondary amenorrhea (HP:0000869)2.05658982
98Premature rupture of membranes (HP:0001788)2.05497235
99Increased mean platelet volume (HP:0011877)2.04527743
100Rough bone trabeculation (HP:0100670)2.03877582
101Cardiovascular calcification (HP:0011915)2.03788571
102Polycythemia (HP:0001901)2.00479842
103EMG: myopathic abnormalities (HP:0003458)1.99813291
104Hyperinsulinemic hypoglycemia (HP:0000825)1.99733596
105Neonatal onset (HP:0003623)1.97777163
106Acanthocytosis (HP:0001927)1.97641748
107Metabolic acidosis (HP:0001942)1.97085372
108Abnormality of the Achilles tendon (HP:0005109)1.96268584
109Abnormality of skeletal muscle fiber size (HP:0012084)1.96149090
110Orthostatic hypotension (HP:0001278)1.93810628
111Abnormal gallbladder physiology (HP:0012438)1.93361515
112Cholecystitis (HP:0001082)1.93361515
113Thrombophlebitis (HP:0004418)1.92768858
114Progressive external ophthalmoplegia (HP:0000590)1.92643536
115Back pain (HP:0003418)1.91074832
116Skull defect (HP:0001362)1.88409335
117Shoulder girdle muscle weakness (HP:0003547)1.87972989
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87866640
119Nausea (HP:0002018)1.86727818
120Difficulty climbing stairs (HP:0003551)1.85924693
121Abnormality of the gallbladder (HP:0005264)1.85837727
122Spontaneous abortion (HP:0005268)1.84657257
123Abnormality of the heme biosynthetic pathway (HP:0010472)1.83917393
124Abnormal platelet volume (HP:0011876)1.83839951
125Lethargy (HP:0001254)1.83721188
126Exercise intolerance (HP:0003546)1.83058402
127Malnutrition (HP:0004395)1.81002576
128Hypokinesia (HP:0002375)1.80828681
129Ventricular tachycardia (HP:0004756)1.80787099
130Spinal rigidity (HP:0003306)1.80786918
131Opisthotonus (HP:0002179)1.80052586
132Reduced subcutaneous adipose tissue (HP:0003758)1.79803646
133Generalized amyotrophy (HP:0003700)1.79796029
134Abnormal number of erythroid precursors (HP:0012131)1.79626616
135Menorrhagia (HP:0000132)1.79410543
136Pancreatic islet-cell hyperplasia (HP:0004510)1.79003348
137Glomerulonephritis (HP:0000099)1.78563504
138Breech presentation (HP:0001623)1.77112730
139Increased nuchal translucency (HP:0010880)1.77024792
140Generalized aminoaciduria (HP:0002909)1.76781207
141Neck muscle weakness (HP:0000467)1.74387347
142Abnormality of the umbilical cord (HP:0010881)1.74089868
143Gout (HP:0001997)1.73792881
144Hemorrhage of the eye (HP:0011885)1.73337292
145Insomnia (HP:0100785)1.73150420
146Gingival bleeding (HP:0000225)1.72093347
147Hypertriglyceridemia (HP:0002155)1.70954371
148Achilles tendon contracture (HP:0001771)1.69244463
149Paralysis (HP:0003470)1.69184655
150Multiple enchondromatosis (HP:0005701)1.69030924
151Diaphragmatic weakness (HP:0009113)1.68340577
152Peritonitis (HP:0002586)1.68044259
153Abnormality of reticulocytes (HP:0004312)1.67924832
154Increased variability in muscle fiber diameter (HP:0003557)1.67839218
155Insulin resistance (HP:0000855)1.67646072
156Irritability (HP:0000737)1.67184826
157Hyperglycemia (HP:0003074)1.66940982
158Upper limb muscle weakness (HP:0003484)1.65416320
159Abnormality of cells of the erythroid lineage (HP:0012130)1.65136176
160Abnormality of endocrine pancreas physiology (HP:0012093)1.64824474
161Abnormality of the pancreatic islet cells (HP:0006476)1.64824474
162Abnormal enzyme/coenzyme activity (HP:0012379)1.64364964
163Pancreatitis (HP:0001733)1.63670978
164Increased connective tissue (HP:0009025)1.63573185
165Ependymoma (HP:0002888)1.62697885
166Deviation of the thumb (HP:0009603)1.61898345
167Proximal placement of thumb (HP:0009623)1.60214427
168Sudden death (HP:0001699)1.60209185
169Fasciculations (HP:0002380)1.59947936
170Lower limb amyotrophy (HP:0007210)1.59608499
171Palpitations (HP:0001962)1.59478675
172Cortical dysplasia (HP:0002539)1.57405355
173Dilated cardiomyopathy (HP:0001644)1.56446314
174Osteolytic defects of the phalanges of the hand (HP:0009771)1.56130235
175Osteolytic defects of the hand bones (HP:0009699)1.56130235
176Lipoatrophy (HP:0100578)1.55412247
177Breast hypoplasia (HP:0003187)1.55240980
178Symptomatic seizures (HP:0011145)1.54417927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.77999452
2BCKDK3.90788571
3PKN23.76552930
4ERN13.65657638
5SMG13.59296235
6KDR3.21941483
7SIK13.21294241
8TRIB33.19535682
9FLT32.83083609
10FGFR42.64633237
11MAP3K102.27869230
12SRPK12.24310921
13NME22.08523212
14TAF11.98963803
15EEF2K1.98277812
16EPHA21.76700424
17ICK1.73729044
18TGFBR11.53571966
19CDC71.53182980
20WEE11.52953108
21MAP2K31.51962382
22NEK11.48582307
23TYK21.44904147
24DAPK11.44845946
25TTN1.42644054
26MAPKAPK31.40652618
27PTK61.39859232
28ARAF1.37780207
29PBK1.32860506
30LIMK11.31679127
31BUB11.30926179
32RPS6KB21.30165271
33VRK11.29229771
34TGFBR21.29143120
35MAP3K31.28660119
36PLK31.27740961
37CHEK21.27199511
38MAP4K11.26587831
39IRAK31.22493188
40NEK21.20975334
41CDK41.16791550
42NME11.16652913
43TESK21.16080337
44RPS6KA41.15238683
45MAPK111.13833180
46STK101.13700911
47PASK1.10879970
48EIF2AK11.09935688
49LRRK21.06957279
50PAK41.04539590
51ZAP701.00164407
52PRPF4B0.98997577
53STK160.98901271
54PIK3CG0.98687697
55SCYL20.98096240
56CDK60.98031643
57NEK90.97727139
58BRSK10.97653070
59PLK40.96691085
60LMTK20.94823359
61MAP3K80.94331644
62TIE10.94232559
63CDK70.93522155
64ACVR1B0.93322939
65CDK120.91861390
66TBK10.91305167
67PDGFRA0.90542528
68BRAF0.89487454
69MAP3K110.88735558
70JAK30.88511173
71TSSK60.87016987
72CHEK10.86973264
73CDK80.84377189
74JAK20.80022507
75MTOR0.77932479
76RIPK10.76935088
77STK40.76120961
78TTK0.75165523
79PIM20.75130278
80ERBB40.73371637
81DMPK0.72685134
82AURKB0.71427130
83MATK0.69935988
84PIM10.69825393
85CDK90.67800367
86ALK0.67486529
87JAK10.67183760
88MST40.67062415
89TAOK30.66447697
90GRK60.65848623
91TLK10.63112440
92DAPK30.61568894
93ABL20.59210095
94MET0.58804169
95CSF1R0.58684636
96PAK10.58654306
97CSK0.58588868
98PAK20.58370163
99ATM0.58281372
100BRSK20.57444482
101LATS10.56669145
102LATS20.55735989
103DYRK1B0.55042021
104EPHB10.55016327
105MAPKAPK50.54349115
106CDK10.53500664
107PHKG10.53157873
108PHKG20.53157873
109MKNK10.53088385
110ATR0.52902791
111INSRR0.52479871
112TAOK20.50991780
113PTK20.50736013
114MOS0.50228045
115PLK10.50213204
116CDK20.50088683
117BTK0.50070606
118OBSCN0.48797999
119KIT0.48624639
120EIF2AK30.48443881
121CSNK2A20.45894706
122TESK10.45744238
123ILK0.45507955
124EIF2AK20.44305610
125AURKA0.44296797
126CSNK1G30.43839176
127CDK11A0.43498082
128CHUK0.41962713
129PDK20.41631782
130PDK30.41209084
131PDK40.41209084
132CDK150.40981449
133MAPK150.40679316
134ZAK0.39816355
135CDK140.39107183
136BMX0.37791850
137CSNK2A10.37397119
138MAP3K70.37376511
139CDK180.36315555
140ITK0.36252884
141CLK10.35914314
142CSNK1G10.35687013
143DDR20.34991455
144EPHA30.34192336
145FGFR10.33547058
146RPS6KA60.31951104
147AKT20.30980587
148MAPK40.30713209
149ERBB20.30554818
150RPS6KC10.29297889

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82031902
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15489033
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13558668
4Nitrogen metabolism_Homo sapiens_hsa009102.69128556
5Arginine biosynthesis_Homo sapiens_hsa002202.63946595
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52815532
7Complement and coagulation cascades_Homo sapiens_hsa046102.45944844
8Tryptophan metabolism_Homo sapiens_hsa003802.42971318
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33329847
10Fatty acid degradation_Homo sapiens_hsa000712.30188844
11Selenocompound metabolism_Homo sapiens_hsa004502.24474372
12One carbon pool by folate_Homo sapiens_hsa006702.24228936
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10946325
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.10702512
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05828754
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02811262
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01685359
18Caffeine metabolism_Homo sapiens_hsa002321.87558602
19Non-homologous end-joining_Homo sapiens_hsa034501.77824595
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74850572
21Chemical carcinogenesis_Homo sapiens_hsa052041.70174886
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67567738
23Biosynthesis of amino acids_Homo sapiens_hsa012301.66169020
24Peroxisome_Homo sapiens_hsa041461.65474368
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61120369
26Propanoate metabolism_Homo sapiens_hsa006401.58010649
27PPAR signaling pathway_Homo sapiens_hsa033201.57048090
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55486496
29Folate biosynthesis_Homo sapiens_hsa007901.52192938
30Fatty acid metabolism_Homo sapiens_hsa012121.51711814
31Staphylococcus aureus infection_Homo sapiens_hsa051501.51132601
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.49796042
33Histidine metabolism_Homo sapiens_hsa003401.48465445
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46996233
35Carbon metabolism_Homo sapiens_hsa012001.46710538
36RNA polymerase_Homo sapiens_hsa030201.45923463
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.45057189
38Phenylalanine metabolism_Homo sapiens_hsa003601.45006004
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.44310051
40beta-Alanine metabolism_Homo sapiens_hsa004101.41481100
41Butanoate metabolism_Homo sapiens_hsa006501.39638173
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39613437
43Pyruvate metabolism_Homo sapiens_hsa006201.35393957
44Sulfur relay system_Homo sapiens_hsa041221.35327027
45DNA replication_Homo sapiens_hsa030301.31731270
46Retinol metabolism_Homo sapiens_hsa008301.27543777
47Tyrosine metabolism_Homo sapiens_hsa003501.23165472
48Starch and sucrose metabolism_Homo sapiens_hsa005001.20695712
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13567024
50Bile secretion_Homo sapiens_hsa049761.08176652
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02549341
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.02230640
53Lysine degradation_Homo sapiens_hsa003101.01143139
54ABC transporters_Homo sapiens_hsa020100.96650356
55Purine metabolism_Homo sapiens_hsa002300.95832174
56Pentose phosphate pathway_Homo sapiens_hsa000300.95548697
57mRNA surveillance pathway_Homo sapiens_hsa030150.95231103
58Arginine and proline metabolism_Homo sapiens_hsa003300.95122904
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94047734
60Fanconi anemia pathway_Homo sapiens_hsa034600.93937564
61Mismatch repair_Homo sapiens_hsa034300.91768578
62Fat digestion and absorption_Homo sapiens_hsa049750.91191887
63Thyroid cancer_Homo sapiens_hsa052160.89981788
64Sulfur metabolism_Homo sapiens_hsa009200.84883825
65Parkinsons disease_Homo sapiens_hsa050120.83706374
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82806885
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82122302
68Glutathione metabolism_Homo sapiens_hsa004800.73811161
69Huntingtons disease_Homo sapiens_hsa050160.71512665
70Fatty acid elongation_Homo sapiens_hsa000620.67102967
71Oxidative phosphorylation_Homo sapiens_hsa001900.66594726
72Galactose metabolism_Homo sapiens_hsa000520.66287658
73Other glycan degradation_Homo sapiens_hsa005110.66039583
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62797136
75Oocyte meiosis_Homo sapiens_hsa041140.57629910
76Base excision repair_Homo sapiens_hsa034100.55134212
77Vitamin B6 metabolism_Homo sapiens_hsa007500.54686346
78Vitamin digestion and absorption_Homo sapiens_hsa049770.54397438
79Pyrimidine metabolism_Homo sapiens_hsa002400.53624324
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52662449
81Adherens junction_Homo sapiens_hsa045200.51499411
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48812982
83RNA degradation_Homo sapiens_hsa030180.48143486
84Alzheimers disease_Homo sapiens_hsa050100.47319583
85Steroid biosynthesis_Homo sapiens_hsa001000.46727833
86Systemic lupus erythematosus_Homo sapiens_hsa053220.46672118
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44612297
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44077035
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42392549
90Metabolic pathways_Homo sapiens_hsa011000.41662746
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41561488
92Dilated cardiomyopathy_Homo sapiens_hsa054140.39773611
93Fructose and mannose metabolism_Homo sapiens_hsa000510.39648194
94Cardiac muscle contraction_Homo sapiens_hsa042600.38842370
95Insulin resistance_Homo sapiens_hsa049310.37419665
96Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37209067
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37027873
98Nucleotide excision repair_Homo sapiens_hsa034200.36668003
99Insulin signaling pathway_Homo sapiens_hsa049100.35588653
100Basal transcription factors_Homo sapiens_hsa030220.34583813
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34216377
102Ribosome_Homo sapiens_hsa030100.33500800
103Proteasome_Homo sapiens_hsa030500.33319001
104Chronic myeloid leukemia_Homo sapiens_hsa052200.31539669
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30190027
106Bladder cancer_Homo sapiens_hsa052190.30049521
107Fatty acid biosynthesis_Homo sapiens_hsa000610.29821757
108Glycerolipid metabolism_Homo sapiens_hsa005610.29728094
109RNA transport_Homo sapiens_hsa030130.28171333
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28155347
111Prion diseases_Homo sapiens_hsa050200.25443047
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.25221343
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.24980065
114Notch signaling pathway_Homo sapiens_hsa043300.24457478
115MicroRNAs in cancer_Homo sapiens_hsa052060.22903393
116Pancreatic cancer_Homo sapiens_hsa052120.22111705
117Antigen processing and presentation_Homo sapiens_hsa046120.21662487
118HTLV-I infection_Homo sapiens_hsa051660.21563349
119Legionellosis_Homo sapiens_hsa051340.21141074
120Basal cell carcinoma_Homo sapiens_hsa052170.15939073
121Spliceosome_Homo sapiens_hsa030400.14706581
122Homologous recombination_Homo sapiens_hsa034400.12455496
123p53 signaling pathway_Homo sapiens_hsa041150.11151633
124Cell cycle_Homo sapiens_hsa041100.09914156
125ECM-receptor interaction_Homo sapiens_hsa045120.08304755
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.08095983
127Small cell lung cancer_Homo sapiens_hsa052220.07540231
128AMPK signaling pathway_Homo sapiens_hsa041520.07465696
129Viral carcinogenesis_Homo sapiens_hsa052030.06276542
130Glucagon signaling pathway_Homo sapiens_hsa049220.05083783
131N-Glycan biosynthesis_Homo sapiens_hsa005100.04692602

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