SLC29A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.98532352
2response to pheromone (GO:0019236)5.97258509
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51577820
4nucleobase catabolic process (GO:0046113)5.41863295
5layer formation in cerebral cortex (GO:0021819)5.16131652
6cell migration in hindbrain (GO:0021535)5.14265373
7behavioral response to nicotine (GO:0035095)4.98803990
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.86196601
9neuron cell-cell adhesion (GO:0007158)4.84458937
10synaptic vesicle maturation (GO:0016188)4.77039803
11negative regulation of microtubule polymerization (GO:0031115)4.62331771
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.61205685
13vocalization behavior (GO:0071625)4.55230883
14locomotory exploration behavior (GO:0035641)4.54712813
15axonal fasciculation (GO:0007413)4.41431125
16neuron recognition (GO:0008038)4.31074569
17central nervous system projection neuron axonogenesis (GO:0021952)4.26480312
18dendritic spine morphogenesis (GO:0060997)4.26348241
19protein localization to synapse (GO:0035418)4.20825476
20dendrite morphogenesis (GO:0048813)4.18671560
21regulation of synaptic vesicle exocytosis (GO:2000300)4.11221877
22regulation of glutamate receptor signaling pathway (GO:1900449)4.11101158
23postsynaptic membrane organization (GO:0001941)4.10907959
24exploration behavior (GO:0035640)4.07849209
25positive regulation of synapse maturation (GO:0090129)3.97222682
26synaptic vesicle exocytosis (GO:0016079)3.95126028
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.86490173
28cerebellar Purkinje cell layer development (GO:0021680)3.82269451
29establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.77251925
30mitochondrion transport along microtubule (GO:0047497)3.77251925
31regulation of synaptic vesicle transport (GO:1902803)3.76222102
32regulation of synapse structural plasticity (GO:0051823)3.75805464
33glutamate secretion (GO:0014047)3.70834965
34innervation (GO:0060384)3.63909896
35cerebellum development (GO:0021549)3.60273214
36fucose catabolic process (GO:0019317)3.58324315
37L-fucose metabolic process (GO:0042354)3.58324315
38L-fucose catabolic process (GO:0042355)3.58324315
39proline transport (GO:0015824)3.54137678
40establishment of mitochondrion localization (GO:0051654)3.51669872
41neurotransmitter secretion (GO:0007269)3.50511053
42axon extension (GO:0048675)3.45463948
43regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40243598
44regulation of neuronal synaptic plasticity (GO:0048168)3.39896133
45central nervous system neuron axonogenesis (GO:0021955)3.37912504
46nephron epithelium morphogenesis (GO:0072088)3.31683005
47nephron tubule morphogenesis (GO:0072078)3.31683005
48auditory behavior (GO:0031223)3.28662667
49cellular ketone body metabolic process (GO:0046950)3.24876328
50presynaptic membrane organization (GO:0097090)3.23482049
51positive regulation of synapse assembly (GO:0051965)3.18669869
52regulation of hexokinase activity (GO:1903299)3.17228178
53regulation of glucokinase activity (GO:0033131)3.17228178
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.14560302
55regulation of respiratory system process (GO:0044065)3.13620615
56positive regulation of dendritic spine morphogenesis (GO:0061003)3.12735965
57alanine transport (GO:0032328)3.12365599
58ionotropic glutamate receptor signaling pathway (GO:0035235)3.11974451
59cerebellar Purkinje cell differentiation (GO:0021702)3.10614083
60regulation of calcium ion-dependent exocytosis (GO:0017158)3.09384108
61synaptic transmission, glutamatergic (GO:0035249)3.08978085
62water-soluble vitamin biosynthetic process (GO:0042364)3.08920971
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.08844111
64presynaptic membrane assembly (GO:0097105)3.08225777
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06878380
66cell communication by electrical coupling (GO:0010644)3.06441945
67regulation of cAMP-dependent protein kinase activity (GO:2000479)3.05258416
68kidney morphogenesis (GO:0060993)3.05180152
69organelle transport along microtubule (GO:0072384)3.02487961
70detection of light stimulus involved in visual perception (GO:0050908)3.02128588
71detection of light stimulus involved in sensory perception (GO:0050962)3.02128588
72neuron projection extension (GO:1990138)3.02041934
73regulation of axon extension (GO:0030516)3.01907484
74regulation of respiratory gaseous exchange (GO:0043576)3.01633909
75hippocampus development (GO:0021766)3.01079744
76synaptic vesicle endocytosis (GO:0048488)3.00192215
77synapse assembly (GO:0007416)3.00185307
78nitric oxide mediated signal transduction (GO:0007263)2.99957168
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99218305
80positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97313930
81regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97090134
82endocrine pancreas development (GO:0031018)2.96388363
83glycerophospholipid catabolic process (GO:0046475)2.93755996
84regulation of synapse maturation (GO:0090128)2.91368254
85positive regulation of axon extension (GO:0045773)2.90932850
86regulation of vesicle fusion (GO:0031338)2.90147242
87axon cargo transport (GO:0008088)2.89436428
88neurotransmitter-gated ion channel clustering (GO:0072578)2.88443297
89cornea development in camera-type eye (GO:0061303)2.87795451
90regulation of neurotransmitter uptake (GO:0051580)2.86837012
91regulation of synapse assembly (GO:0051963)2.86542240
92growth hormone secretion (GO:0030252)2.85341770
93cell differentiation in hindbrain (GO:0021533)2.85063324
94activation of protein kinase A activity (GO:0034199)2.84632928
95adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.83831774
96ketone body metabolic process (GO:1902224)2.83702177
97glutamate receptor signaling pathway (GO:0007215)2.82973065
98primary amino compound metabolic process (GO:1901160)2.82645184
99dendritic spine organization (GO:0097061)2.82346800
100regulation of type B pancreatic cell apoptotic process (GO:2000674)2.82221841
101clathrin coat assembly (GO:0048268)2.81513318
102regulation of microtubule polymerization (GO:0031113)2.80841704
103dopamine receptor signaling pathway (GO:0007212)2.80637586
104transmission of nerve impulse (GO:0019226)2.80515483
105cerebellar granule cell differentiation (GO:0021707)2.80218601
106indolalkylamine metabolic process (GO:0006586)2.79694544
107response to auditory stimulus (GO:0010996)2.79625862
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79446468
109regulation of synapse organization (GO:0050807)2.79200111
110insulin secretion (GO:0030073)2.78067403
111positive regulation of dendritic spine development (GO:0060999)2.77895099
112renal tubule morphogenesis (GO:0061333)2.77334250
113serotonin metabolic process (GO:0042428)2.76941819
114neuron migration (GO:0001764)2.75132358
115neuromuscular process controlling balance (GO:0050885)2.74541254
116respiratory chain complex IV assembly (GO:0008535)2.74133086
117neuron-neuron synaptic transmission (GO:0007270)2.73009619
118gamma-aminobutyric acid transport (GO:0015812)2.72522083
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71529619
120synapse organization (GO:0050808)2.70878582
121positive regulation of membrane potential (GO:0045838)2.70727565
122regulation of neurotransmitter secretion (GO:0046928)2.70560446
123cochlea development (GO:0090102)2.70356607
124regulation of extent of cell growth (GO:0061387)2.69025568
125neurotransmitter transport (GO:0006836)2.68832452
126response to dietary excess (GO:0002021)2.68038705
127dendrite development (GO:0016358)2.67702018
128establishment of nucleus localization (GO:0040023)2.66982205
129regulation of NFAT protein import into nucleus (GO:0051532)2.66851392
130membrane repolarization during action potential (GO:0086011)2.66292451
131positive regulation of glycolytic process (GO:0045821)2.66008490
132indole-containing compound catabolic process (GO:0042436)2.65847445
133indolalkylamine catabolic process (GO:0046218)2.65847445
134tryptophan catabolic process (GO:0006569)2.65847445
135spinal cord motor neuron differentiation (GO:0021522)2.64220282
136startle response (GO:0001964)2.63117269
137neuronal action potential (GO:0019228)2.60480486
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52647158
139synaptic transmission, cholinergic (GO:0007271)2.52632300
140indole-containing compound metabolic process (GO:0042430)2.50642624
141reflex (GO:0060004)2.48377611
142inositol phosphate catabolic process (GO:0071545)2.47981110
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46385061
144purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44393539
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44393539
146cytochrome complex assembly (GO:0017004)2.44232369
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42200442
148protein localization to cilium (GO:0061512)2.42040738
149axoneme assembly (GO:0035082)2.40992315
150regulation of action potential (GO:0098900)2.39873548
151kynurenine metabolic process (GO:0070189)2.39779196
152dentate gyrus development (GO:0021542)2.38269065
153chemosensory behavior (GO:0007635)2.38177730
154C4-dicarboxylate transport (GO:0015740)2.38115952
155protein polyglutamylation (GO:0018095)2.36883403
156detection of calcium ion (GO:0005513)2.36399977
157neuronal action potential propagation (GO:0019227)2.36252821
158somite development (GO:0061053)2.36244695
159regulation of memory T cell differentiation (GO:0043380)2.35856341
160neuromuscular synaptic transmission (GO:0007274)2.33758218
161neurotransmitter metabolic process (GO:0042133)2.33491190
162epithelial cell fate commitment (GO:0072148)2.32735519
163cAMP catabolic process (GO:0006198)2.32167618
164behavioral response to ethanol (GO:0048149)2.30848401
165tryptophan metabolic process (GO:0006568)2.29420256
166positive regulation of meiosis (GO:0045836)2.29339364
167positive regulation of oligodendrocyte differentiation (GO:0048714)2.27608406
168cellular response to ATP (GO:0071318)2.26980287
169regulation of acrosome reaction (GO:0060046)2.26603266
170hindbrain development (GO:0030902)2.26090571
171nonmotile primary cilium assembly (GO:0035058)2.25523892
172neuron fate determination (GO:0048664)2.25144454
173aromatic amino acid family catabolic process (GO:0009074)2.24252678
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.24213932
175platelet dense granule organization (GO:0060155)2.23234989
176membrane depolarization during action potential (GO:0086010)2.23058177
177epithelial cilium movement (GO:0003351)2.22936988
178regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.22140220
179regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.22140220
180cyclic nucleotide catabolic process (GO:0009214)2.22012110
181peristalsis (GO:0030432)2.20838664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.60279884
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.13546194
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.10894290
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93298638
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.92907691
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90910689
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.90521304
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90211172
9GBX2_23144817_ChIP-Seq_PC3_Human2.82918470
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65275966
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62677772
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56984226
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54193547
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54193547
15REST_18959480_ChIP-ChIP_MESCs_Mouse2.54173505
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.54114806
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43150855
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40951779
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39293180
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38370634
21VDR_22108803_ChIP-Seq_LS180_Human2.36979713
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33027883
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29376969
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.26987198
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22712603
26DROSHA_22980978_ChIP-Seq_HELA_Human2.20367258
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.15557885
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13594446
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08911599
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.05576642
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02082800
32IGF1R_20145208_ChIP-Seq_DFB_Human1.98984171
33ZNF274_21170338_ChIP-Seq_K562_Hela1.92320738
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88482328
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79775534
36* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.79209067
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73479789
38TAF15_26573619_Chip-Seq_HEK293_Human1.72495718
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.69983433
40OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.61157302
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58509090
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.57048863
43RNF2_27304074_Chip-Seq_NSC_Mouse1.54559115
44FUS_26573619_Chip-Seq_HEK293_Human1.54057601
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.53875752
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.52661239
47BCAT_22108803_ChIP-Seq_LS180_Human1.52158654
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51164981
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51077090
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49887241
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49164950
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.45353073
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44315286
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44135321
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44101507
56ER_23166858_ChIP-Seq_MCF-7_Human1.42784174
57KDM2B_26808549_Chip-Seq_K562_Human1.42614239
58AR_21572438_ChIP-Seq_LNCaP_Human1.42241144
59EWS_26573619_Chip-Seq_HEK293_Human1.41848650
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.38794577
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37933107
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.37021064
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35427802
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34247520
65* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30309116
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30002027
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29658109
68TCF4_23295773_ChIP-Seq_U87_Human1.29308620
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29154966
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28564463
71RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28504176
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27043417
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25139062
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24676553
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21223195
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20948800
77CBP_20019798_ChIP-Seq_JUKART_Human1.20948800
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.20165951
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20025086
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18761639
81TP53_22573176_ChIP-Seq_HFKS_Human1.18616607
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18321709
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18319871
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16099662
85* AR_19668381_ChIP-Seq_PC3_Human1.15447052
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15123352
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14043831
88TCF4_22108803_ChIP-Seq_LS180_Human1.14013977
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13372203
90SOX2_19829295_ChIP-Seq_ESCs_Human1.13166820
91NANOG_19829295_ChIP-Seq_ESCs_Human1.13166820
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10335146
93YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09568918
94SMAD4_21799915_ChIP-Seq_A2780_Human1.09131775
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.08766169
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07909007
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.07791327
98ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07726353
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06006726
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.06006726
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05881785
102WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04778997
103* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04612920
104GATA3_21878914_ChIP-Seq_MCF-7_Human1.04285652
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01273296
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.01206240
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00454800
108CTCF_27219007_Chip-Seq_Bcells_Human1.00436372
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.00342456
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00082041
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99896368
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.99037660
113EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98632121
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.98151862
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97885415
116P300_19829295_ChIP-Seq_ESCs_Human0.97810695
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96952293
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96467595
119NCOR_22424771_ChIP-Seq_293T_Human0.96419469
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96354632
121STAT3_23295773_ChIP-Seq_U87_Human0.95731906
122SMAD3_21741376_ChIP-Seq_EPCs_Human0.95506663
123NFE2_27457419_Chip-Seq_LIVER_Mouse0.94887003
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94412165
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.94261276
126* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93488687
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91649122
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91649122
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91446553
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91234963
131AR_25329375_ChIP-Seq_VCAP_Human0.89939614
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83720059
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83317973
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.83192779
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83114073
136POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81942359
137RUNX2_22187159_ChIP-Seq_PCA_Human0.81287634
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79745913
139MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79291659
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78764348
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.78698162
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78356486
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77827174
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77267883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.66941703
2MP0004270_analgesia3.46263261
3MP0005423_abnormal_somatic_nervous3.27286554
4MP0003635_abnormal_synaptic_transmissio3.15058041
5MP0003195_calcinosis3.08470666
6MP0003122_maternal_imprinting3.05596684
7MP0003880_abnormal_central_pattern3.00994110
8MP0000778_abnormal_nervous_system2.92554789
9MP0005645_abnormal_hypothalamus_physiol2.92469288
10MP0006276_abnormal_autonomic_nervous2.71226947
11MP0002063_abnormal_learning/memory/cond2.67422343
12MP0002734_abnormal_mechanical_nocicepti2.57757444
13MP0002876_abnormal_thyroid_physiology2.43202252
14MP0002184_abnormal_innervation2.43008649
15MP0002735_abnormal_chemical_nociception2.41022091
16MP0002909_abnormal_adrenal_gland2.36275821
17MP0002733_abnormal_thermal_nociception2.35084779
18MP0002837_dystrophic_cardiac_calcinosis2.27762342
19MP0009745_abnormal_behavioral_response2.17991918
20MP0002572_abnormal_emotion/affect_behav2.14684507
21MP0001968_abnormal_touch/_nociception2.10893908
22MP0009780_abnormal_chondrocyte_physiolo2.05121436
23MP0008877_abnormal_DNA_methylation2.02354748
24MP0005551_abnormal_eye_electrophysiolog2.01895213
25MP0000955_abnormal_spinal_cord1.97468325
26MP0003283_abnormal_digestive_organ1.96820830
27MP0002064_seizures1.96747931
28MP0002638_abnormal_pupillary_reflex1.94270877
29MP0004858_abnormal_nervous_system1.92944912
30MP0004811_abnormal_neuron_physiology1.92575738
31MP0002557_abnormal_social/conspecific_i1.90263810
32MP0001970_abnormal_pain_threshold1.86536342
33MP0001440_abnormal_grooming_behavior1.85771013
34MP0002751_abnormal_autonomic_nervous1.85455099
35MP0005379_endocrine/exocrine_gland_phen1.83626266
36MP0001984_abnormal_olfaction1.77511209
37MP0010329_abnormal_lipoprotein_level1.72094446
38MP0009046_muscle_twitch1.69094332
39MP0003011_delayed_dark_adaptation1.61584247
40MP0002272_abnormal_nervous_system1.61294639
41MP0002938_white_spotting1.59470045
42MP0003787_abnormal_imprinting1.59025345
43MP0001486_abnormal_startle_reflex1.58838045
44MP0010386_abnormal_urinary_bladder1.58709215
45MP0002102_abnormal_ear_morphology1.57603607
46MP0002067_abnormal_sensory_capabilities1.57509515
47MP0001529_abnormal_vocalization1.55241716
48MP0002653_abnormal_ependyma_morphology1.55226334
49MP0000631_abnormal_neuroendocrine_gland1.55166416
50MP0002882_abnormal_neuron_morphology1.53370480
51MP0003121_genomic_imprinting1.52727604
52MP0001502_abnormal_circadian_rhythm1.51800384
53MP0008875_abnormal_xenobiotic_pharmacok1.50151816
54MP0008961_abnormal_basal_metabolism1.46106781
55MP0004924_abnormal_behavior1.42844929
56MP0005386_behavior/neurological_phenoty1.42844929
57MP0005646_abnormal_pituitary_gland1.41704142
58MP0006292_abnormal_olfactory_placode1.40497169
59MP0002152_abnormal_brain_morphology1.38614346
60MP0005499_abnormal_olfactory_system1.38056492
61MP0005394_taste/olfaction_phenotype1.38056492
62MP0003329_amyloid_beta_deposits1.37934915
63MP0002736_abnormal_nociception_after1.37632344
64MP0008872_abnormal_physiological_respon1.37176061
65MP0006072_abnormal_retinal_apoptosis1.34641503
66MP0001348_abnormal_lacrimal_gland1.32133177
67MP0004885_abnormal_endolymph1.28119731
68MP0002163_abnormal_gland_morphology1.26102969
69MP0001986_abnormal_taste_sensitivity1.25691667
70MP0004043_abnormal_pH_regulation1.25035102
71MP0008569_lethality_at_weaning1.24893183
72MP0002066_abnormal_motor_capabilities/c1.24232743
73MP0003861_abnormal_nervous_system1.24189645
74MP0003183_abnormal_peptide_metabolism1.24036893
75MP0005084_abnormal_gallbladder_morpholo1.23173539
76MP0005448_abnormal_energy_balance1.22556938
77MP0008789_abnormal_olfactory_epithelium1.21155415
78MP0003119_abnormal_digestive_system1.18050113
79MP0005670_abnormal_white_adipose1.16452220
80MP0004130_abnormal_muscle_cell1.16449158
81MP0005187_abnormal_penis_morphology1.15962348
82MP0002160_abnormal_reproductive_system1.15775198
83MP0001485_abnormal_pinna_reflex1.15217327
84MP0003136_yellow_coat_color1.15078003
85MP0001501_abnormal_sleep_pattern1.14283082
86MP0002822_catalepsy1.14047985
87MP0002234_abnormal_pharynx_morphology1.13537386
88MP0002928_abnormal_bile_duct1.11193029
89MP0004133_heterotaxia1.09993924
90MP0003890_abnormal_embryonic-extraembry1.08794889
91MP0005332_abnormal_amino_acid1.05420598
92MP0002069_abnormal_eating/drinking_beha1.02932097
93MP0005365_abnormal_bile_salt1.01306771
94MP0003646_muscle_fatigue1.00791474
95MP0000013_abnormal_adipose_tissue0.99027061
96MP0002752_abnormal_somatic_nervous0.98296662
97MP0002078_abnormal_glucose_homeostasis0.97361932
98MP0000537_abnormal_urethra_morphology0.96796392
99MP0005389_reproductive_system_phenotype0.95277586
100MP0005195_abnormal_posterior_eye0.95016419
101MP0000566_synostosis0.94698750
102MP0005220_abnormal_exocrine_pancreas0.92523501
103MP0004019_abnormal_vitamin_homeostasis0.92138456
104MP0001299_abnormal_eye_distance/0.92112855
105MP0008995_early_reproductive_senescence0.90656828
106MP0000538_abnormal_urinary_bladder0.90377245
107MP0000569_abnormal_digit_pigmentation0.90233815
108MP0000427_abnormal_hair_cycle0.90230964
109MP0003879_abnormal_hair_cell0.88414843
110MP0001905_abnormal_dopamine_level0.87525303
111MP0001944_abnormal_pancreas_morphology0.86724377
112MP0005085_abnormal_gallbladder_physiolo0.85609843
113MP0005167_abnormal_blood-brain_barrier0.84669129
114MP0004233_abnormal_muscle_weight0.83884149
115MP0003123_paternal_imprinting0.81346026
116MP0000026_abnormal_inner_ear0.80711421
117MP0005174_abnormal_tail_pigmentation0.79254241
118MP0004142_abnormal_muscle_tone0.78351018
119MP0003634_abnormal_glial_cell0.75286033
120MP0001188_hyperpigmentation0.75138521
121MP0003942_abnormal_urinary_system0.71422576
122MP0003633_abnormal_nervous_system0.70977296
123MP0003172_abnormal_lysosome_physiology0.70889605
124MP0002081_perinatal_lethality0.70489398
125MP0000534_abnormal_ureter_morphology0.70167230
126MP0003631_nervous_system_phenotype0.69503227
127MP0002229_neurodegeneration0.69151032
128MP0003953_abnormal_hormone_level0.68866529
129MP0005253_abnormal_eye_physiology0.68781420
130MP0003137_abnormal_impulse_conducting0.66880717
131MP0002693_abnormal_pancreas_physiology0.66866192
132MP0000678_abnormal_parathyroid_gland0.65802382
133MP0004085_abnormal_heartbeat0.65612059
134MP0004742_abnormal_vestibular_system0.64738824
135MP0002082_postnatal_lethality0.63864891
136MP0010770_preweaning_lethality0.63864891
137MP0003632_abnormal_nervous_system0.63775620

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.58888927
2Visual hallucinations (HP:0002367)3.89402910
3Focal motor seizures (HP:0011153)3.80717900
4Supranuclear gaze palsy (HP:0000605)3.68900936
5Failure to thrive in infancy (HP:0001531)3.68201159
6Limb dystonia (HP:0002451)3.61402930
7Congenital stationary night blindness (HP:0007642)3.57954350
8Focal seizures (HP:0007359)3.56087259
9Agitation (HP:0000713)3.53787423
10Pancreatic cysts (HP:0001737)3.43536559
11Nephronophthisis (HP:0000090)3.42941288
12Polyphagia (HP:0002591)3.39927954
13Abnormality of midbrain morphology (HP:0002418)3.38412557
14Molar tooth sign on MRI (HP:0002419)3.38412557
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.31872408
16Ankle clonus (HP:0011448)3.25014950
17Amyotrophic lateral sclerosis (HP:0007354)3.19654850
18Progressive cerebellar ataxia (HP:0002073)3.19496154
19Pancreatic fibrosis (HP:0100732)3.11011905
20Mutism (HP:0002300)3.10931194
21Large for gestational age (HP:0001520)3.05012515
22Amblyopia (HP:0000646)3.03597499
23True hermaphroditism (HP:0010459)3.00568672
24Ketoacidosis (HP:0001993)2.95450667
25Type II lissencephaly (HP:0007260)2.91390064
26Drooling (HP:0002307)2.90362574
27Excessive salivation (HP:0003781)2.90362574
28Epileptic encephalopathy (HP:0200134)2.89786695
29Hemiparesis (HP:0001269)2.89157866
30Papilledema (HP:0001085)2.85587571
31Abnormality of the renal medulla (HP:0100957)2.84153232
32Aplasia/Hypoplasia of the brainstem (HP:0007362)2.83414623
33Hypoplasia of the brainstem (HP:0002365)2.83414623
34Abnormal drinking behavior (HP:0030082)2.81113303
35Polydipsia (HP:0001959)2.81113303
36Abnormality of the renal cortex (HP:0011035)2.80796295
37Pendular nystagmus (HP:0012043)2.75593263
38Abnormal eating behavior (HP:0100738)2.71249344
39Intestinal atresia (HP:0011100)2.71047333
40Sleep apnea (HP:0010535)2.70127171
41Attenuation of retinal blood vessels (HP:0007843)2.69626374
42Hyperventilation (HP:0002883)2.67880060
43Tubular atrophy (HP:0000092)2.67865647
44Lissencephaly (HP:0001339)2.64823221
45EEG with generalized epileptiform discharges (HP:0011198)2.61754537
46Depression (HP:0000716)2.58020762
47Hypsarrhythmia (HP:0002521)2.56746299
48Action tremor (HP:0002345)2.56552784
49Epileptiform EEG discharges (HP:0011182)2.55767308
50Akinesia (HP:0002304)2.55680420
51Hepatoblastoma (HP:0002884)2.53192238
52Pheochromocytoma (HP:0002666)2.48751249
53Abnormal rod and cone electroretinograms (HP:0008323)2.48737971
54Medial flaring of the eyebrow (HP:0010747)2.46517729
55Hyperinsulinemic hypoglycemia (HP:0000825)2.46110152
56Ketosis (HP:0001946)2.45525387
57Abnormality of the corticospinal tract (HP:0002492)2.44398950
58Genetic anticipation (HP:0003743)2.43592760
59Broad-based gait (HP:0002136)2.42084149
60Gaze-evoked nystagmus (HP:0000640)2.39721317
61Febrile seizures (HP:0002373)2.38187007
62Cystic liver disease (HP:0006706)2.36782021
63Obstructive sleep apnea (HP:0002870)2.36534643
64Exotropia (HP:0000577)2.35572035
65Hypoglycemic coma (HP:0001325)2.35323740
66Pachygyria (HP:0001302)2.29545161
67Congenital sensorineural hearing impairment (HP:0008527)2.27594295
68Generalized tonic-clonic seizures (HP:0002069)2.25619062
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.24726507
70Megalencephaly (HP:0001355)2.24024684
71Hypoventilation (HP:0002791)2.23694895
72Hypomagnesemia (HP:0002917)2.22393873
73Increased corneal curvature (HP:0100692)2.21966717
74Keratoconus (HP:0000563)2.21966717
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.21940548
76Hypoplasia of the fovea (HP:0007750)2.21940548
77Insomnia (HP:0100785)2.21642288
78Morphological abnormality of the pyramidal tract (HP:0002062)2.21204004
79Chronic hepatic failure (HP:0100626)2.20427604
80Absence seizures (HP:0002121)2.19932946
81Abnormality of the lower motor neuron (HP:0002366)2.19491372
82Poor eye contact (HP:0000817)2.18624105
83Decreased circulating renin level (HP:0003351)2.16127800
84Atonic seizures (HP:0010819)2.16026340
85Hyperthyroidism (HP:0000836)2.15538722
86Orthostatic hypotension (HP:0001278)2.15119349
87Cerebral inclusion bodies (HP:0100314)2.14139846
88Severe muscular hypotonia (HP:0006829)2.13882145
89Neurofibrillary tangles (HP:0002185)2.11812211
90Optic nerve hypoplasia (HP:0000609)2.11363442
91Abolished electroretinogram (ERG) (HP:0000550)2.10906655
92Macroorchidism (HP:0000053)2.10719959
93Polyuria (HP:0000103)2.10381649
94Urinary urgency (HP:0000012)2.10337014
95Inability to walk (HP:0002540)2.10264687
96Gait imbalance (HP:0002141)2.08270289
97Anxiety (HP:0000739)2.07741155
98Truncal ataxia (HP:0002078)2.06363386
99Neoplasm of the heart (HP:0100544)2.05823128
100Bony spicule pigmentary retinopathy (HP:0007737)2.05385189
101Neuroendocrine neoplasm (HP:0100634)2.04555522
102Open mouth (HP:0000194)2.04520934
103Torticollis (HP:0000473)2.04451598
104Sclerocornea (HP:0000647)2.03966160
105Astrocytoma (HP:0009592)2.02254507
106Abnormality of the astrocytes (HP:0100707)2.02254507
107Hyperglycemia (HP:0003074)2.02087545
108Specific learning disability (HP:0001328)2.01715179
109Spastic gait (HP:0002064)2.01505558
110Late onset (HP:0003584)2.01494993
111Renal cortical cysts (HP:0000803)2.01462668
112Atrophy/Degeneration involving motor neurons (HP:0007373)2.00719358
113Apathy (HP:0000741)1.99737813
114Dialeptic seizures (HP:0011146)1.99388933
115Hypothermia (HP:0002045)1.98830071
116Hypercortisolism (HP:0001578)1.98653622
117Methylmalonic acidemia (HP:0002912)1.98581428
118Impaired vibration sensation in the lower limbs (HP:0002166)1.96700545
119Furrowed tongue (HP:0000221)1.96443027
120Absent speech (HP:0001344)1.95623595
121Menstrual irregularities (HP:0000858)1.95580294
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95262950
123Impaired social interactions (HP:0000735)1.95184355
124Abnormal social behavior (HP:0012433)1.95184355
125Enlarged penis (HP:0000040)1.94692573
126Ventricular fibrillation (HP:0001663)1.92275482
127Esotropia (HP:0000565)1.92002958
128Abnormality of alanine metabolism (HP:0010916)1.92001026
129Hyperalaninemia (HP:0003348)1.92001026
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92001026
131Restlessness (HP:0000711)1.91929304
132Decreased central vision (HP:0007663)1.89408620
133Male pseudohermaphroditism (HP:0000037)1.89313635
134Focal dystonia (HP:0004373)1.87880529
135Protruding tongue (HP:0010808)1.85263760
136Hypoglycemic seizures (HP:0002173)1.84093873
137Abnormal urine output (HP:0012590)1.83541619
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.83391188
139Congenital glaucoma (HP:0001087)1.82677090
140Tachypnea (HP:0002789)1.82667129
141Sporadic (HP:0003745)1.82122310
142Mesangial abnormality (HP:0001966)1.80112022
143Shoulder girdle muscle weakness (HP:0003547)1.80047532
144Impaired smooth pursuit (HP:0007772)1.79707634
145Increased circulating renin level (HP:0000848)1.79171111
146Hypoplasia of the corpus callosum (HP:0002079)1.78800781
147Abnormality of salivation (HP:0100755)1.78490304
148Anosmia (HP:0000458)1.78160206
149Abnormality of the pancreatic islet cells (HP:0006476)1.77520285
150Abnormality of endocrine pancreas physiology (HP:0012093)1.77520285
151Aqueductal stenosis (HP:0002410)1.77170463
152Diminished motivation (HP:0000745)1.76708371
153Hyperacusis (HP:0010780)1.76304892
154Fetal akinesia sequence (HP:0001989)1.76170088
155Poor suck (HP:0002033)1.75511040
156Pointed chin (HP:0000307)1.74989143
157Abnormality of the fovea (HP:0000493)1.74474697
158Stereotypic behavior (HP:0000733)1.72982279
159Methylmalonic aciduria (HP:0012120)1.72645295
160Craniofacial dystonia (HP:0012179)1.72427055
161Diplopia (HP:0000651)1.72308644
162Abnormality of binocular vision (HP:0011514)1.72308644
163Congenital malformation of the right heart (HP:0011723)1.71797057
164Double outlet right ventricle (HP:0001719)1.71797057
165Progressive inability to walk (HP:0002505)1.71717661
166Chorioretinal atrophy (HP:0000533)1.70931654
167Abnormality of the vitreous humor (HP:0004327)1.70538027
168Congenital primary aphakia (HP:0007707)1.70455418
169Cerebellar dysplasia (HP:0007033)1.70377683
170Disproportionate short-trunk short stature (HP:0003521)1.69182641
171Insulin-resistant diabetes mellitus (HP:0000831)1.69113301
172Prominent supraorbital ridges (HP:0000336)1.68944918
173Retinal dysplasia (HP:0007973)1.68942504
174Abnormality of renin-angiotensin system (HP:0000847)1.66934740
175Neoplasm of the adrenal cortex (HP:0100641)1.65899401
176Abnormality of renal excretion (HP:0011036)1.65603377
177Genital tract atresia (HP:0001827)1.65158303
178Progressive macrocephaly (HP:0004481)1.64255589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.81194839
2FRK6.31222989
3NTRK33.94924949
4MAP3K93.29521588
5ADRBK22.95819363
6MINK12.75715864
7GRK12.67714531
8DYRK22.57353970
9MAP4K22.48909765
10PINK12.44087582
11MAP3K42.27814206
12MAPK132.26106144
13NTRK22.24972215
14WNK32.21467854
15KSR12.18736851
16UHMK12.13687854
17PAK61.94602455
18SIK31.87836239
19ACVR1B1.86275464
20PHKG11.84772019
21PHKG21.84772019
22MAP2K71.76755662
23ERBB31.63982967
24SIK21.62651785
25ZAK1.56774406
26NTRK11.50223227
27PRKD31.43096249
28TNIK1.42585191
29BCR1.38922552
30LATS21.34970839
31DAPK21.34354287
32CDK51.34114416
33NUAK11.31033079
34EPHB21.26149010
35EPHA41.24051269
36CSNK1G21.22097583
37LIMK11.21586341
38MAPK151.18942940
39DYRK1A1.17613495
40TLK11.15864042
41STK391.15733888
42CASK1.14972733
43TYRO31.14013751
44PAK31.10136784
45MARK21.07373582
46MAP2K41.06535207
47KSR21.05591797
48PNCK1.05564869
49CAMKK11.05050477
50OXSR11.03669481
51STK38L0.98576791
52SCYL20.97871186
53CSNK1G30.97777046
54MAP3K20.97132633
55INSRR0.94976473
56CDK180.94059140
57PRKCG0.93824077
58GRK50.93182211
59CAMK1G0.90117443
60MAP3K120.89066973
61PRPF4B0.87811873
62CDK140.87746607
63RPS6KA20.86193813
64ICK0.86111950
65MKNK20.85983813
66MAPKAPK30.85872850
67CDK150.83764408
68CAMKK20.79963762
69RET0.78618226
70CSNK1A1L0.77372446
71DAPK10.75580637
72CDK11A0.74765588
73CDC42BPA0.72281942
74PTK2B0.70801230
75PRKCZ0.70307903
76NLK0.68203995
77PRKAA20.66531877
78STK30.66440490
79IRAK20.65050949
80TIE10.63809470
81HIPK20.62680835
82PDGFRA0.61875583
83DYRK1B0.61546225
84FGFR20.60760037
85CSNK1G10.60543375
86FER0.60513421
87PLK20.57543947
88PASK0.57231846
89SGK4940.57118938
90SGK2230.57118938
91TESK10.55953004
92MAPK90.54253127
93WNK40.53699136
94PRKACA0.53238835
95CSNK1D0.51897927
96CAMK2A0.51643833
97TRIM280.51516765
98RIPK10.51031190
99BMPR1B0.50377551
100CAMK2D0.49772603
101CCNB10.49711072
102SGK20.48916014
103ALK0.48867081
104CSNK1A10.48332420
105CAMK2B0.47558046
106PRKCI0.47052409
107PKN10.46767778
108MAPKAPK50.46636265
109STK110.46460760
110EPHA30.45833471
111MAP2K60.45512605
112PRKG10.45222973
113ERBB20.44907276
114CAMK10.44590384
115PRKCE0.44394084
116BRSK10.44386086
117TAOK30.44074620
118BCKDK0.42253365
119FGFR30.41763201
120PIK3CA0.41643287
121MAP2K10.41288709
122PTK20.39097533
123CAMK1D0.37726936
124IRAK10.36584573
125STK380.35932193
126PRKCA0.35809761
127PRKAA10.35519559
128PRKCH0.34705662
129CHUK0.34436581
130PRKACB0.34336366
131CAMK40.33376059
132MUSK0.33273591
133PRKD20.32624608
134ADRBK10.32475223
135SGK10.32129111
136DYRK30.31874790
137CSNK1E0.31468593
138MAPK80.31404268
139VRK10.31350133

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.97181349
2Nicotine addiction_Homo sapiens_hsa050332.86199115
3Insulin secretion_Homo sapiens_hsa049112.41132566
4Circadian entrainment_Homo sapiens_hsa047132.38799356
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34766700
6Dopaminergic synapse_Homo sapiens_hsa047282.29544163
7GABAergic synapse_Homo sapiens_hsa047272.23859421
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20746432
9Amphetamine addiction_Homo sapiens_hsa050312.19464909
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.17040816
11Long-term potentiation_Homo sapiens_hsa047202.16766830
12Glutamatergic synapse_Homo sapiens_hsa047242.09331150
13Cocaine addiction_Homo sapiens_hsa050302.08285688
14Axon guidance_Homo sapiens_hsa043602.07113989
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.07029798
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05113153
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.98687889
18Tryptophan metabolism_Homo sapiens_hsa003801.96349884
19Cholinergic synapse_Homo sapiens_hsa047251.91710653
20Morphine addiction_Homo sapiens_hsa050321.88307975
21Olfactory transduction_Homo sapiens_hsa047401.88294808
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79487777
23Taste transduction_Homo sapiens_hsa047421.76808195
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76515993
25Nitrogen metabolism_Homo sapiens_hsa009101.75435821
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74412844
27Serotonergic synapse_Homo sapiens_hsa047261.65206700
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64685393
29Gap junction_Homo sapiens_hsa045401.61373858
30Type II diabetes mellitus_Homo sapiens_hsa049301.59260663
31Long-term depression_Homo sapiens_hsa047301.56742327
32Selenocompound metabolism_Homo sapiens_hsa004501.55931890
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55902791
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52577135
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50895992
36Oxidative phosphorylation_Homo sapiens_hsa001901.50878737
37Linoleic acid metabolism_Homo sapiens_hsa005911.50874423
38Protein export_Homo sapiens_hsa030601.40207349
39Estrogen signaling pathway_Homo sapiens_hsa049151.39895358
40ABC transporters_Homo sapiens_hsa020101.37135661
41Gastric acid secretion_Homo sapiens_hsa049711.35642589
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35632542
43ErbB signaling pathway_Homo sapiens_hsa040121.33310320
44Endometrial cancer_Homo sapiens_hsa052131.32854140
45Vibrio cholerae infection_Homo sapiens_hsa051101.31431039
46Salivary secretion_Homo sapiens_hsa049701.30939962
47GnRH signaling pathway_Homo sapiens_hsa049121.30604459
48Renin secretion_Homo sapiens_hsa049241.27972694
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26637158
50Sulfur metabolism_Homo sapiens_hsa009201.24028045
51Oxytocin signaling pathway_Homo sapiens_hsa049211.23646185
52Ether lipid metabolism_Homo sapiens_hsa005651.22140173
53beta-Alanine metabolism_Homo sapiens_hsa004101.21952689
54Glioma_Homo sapiens_hsa052141.21782273
55Glycerolipid metabolism_Homo sapiens_hsa005611.21748427
56Melanogenesis_Homo sapiens_hsa049161.20147265
57Fat digestion and absorption_Homo sapiens_hsa049751.17859089
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16439530
59Peroxisome_Homo sapiens_hsa041461.15494847
60Propanoate metabolism_Homo sapiens_hsa006401.14209628
61Colorectal cancer_Homo sapiens_hsa052101.11875303
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10398314
63Histidine metabolism_Homo sapiens_hsa003401.09855628
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.08989108
65Ovarian steroidogenesis_Homo sapiens_hsa049131.08448804
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08359716
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06308163
68Fatty acid degradation_Homo sapiens_hsa000711.05907436
69Fatty acid metabolism_Homo sapiens_hsa012121.04495792
70Oocyte meiosis_Homo sapiens_hsa041141.00693756
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99745498
72Collecting duct acid secretion_Homo sapiens_hsa049660.99117565
73cAMP signaling pathway_Homo sapiens_hsa040240.98701014
74Steroid biosynthesis_Homo sapiens_hsa001000.96380022
75Alcoholism_Homo sapiens_hsa050340.95395311
76Basal transcription factors_Homo sapiens_hsa030220.94279106
77Retinol metabolism_Homo sapiens_hsa008300.94034528
78Wnt signaling pathway_Homo sapiens_hsa043100.93150457
79PPAR signaling pathway_Homo sapiens_hsa033200.92472916
80Calcium signaling pathway_Homo sapiens_hsa040200.92387523
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91298821
82Chemical carcinogenesis_Homo sapiens_hsa052040.91255718
83Parkinsons disease_Homo sapiens_hsa050120.91172268
84Fatty acid elongation_Homo sapiens_hsa000620.89704436
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.88851025
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88691949
87Renal cell carcinoma_Homo sapiens_hsa052110.88618308
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87634290
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.87194826
90mTOR signaling pathway_Homo sapiens_hsa041500.84251150
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83692829
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82940646
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81052905
94Caffeine metabolism_Homo sapiens_hsa002320.80104278
95VEGF signaling pathway_Homo sapiens_hsa043700.79779979
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79421241
97N-Glycan biosynthesis_Homo sapiens_hsa005100.79105485
98Choline metabolism in cancer_Homo sapiens_hsa052310.79067960
99Vitamin B6 metabolism_Homo sapiens_hsa007500.77003480
100Insulin signaling pathway_Homo sapiens_hsa049100.76638433
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76606420
102Prion diseases_Homo sapiens_hsa050200.75600419
103Glucagon signaling pathway_Homo sapiens_hsa049220.75561048
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.74993100
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74689452
106Basal cell carcinoma_Homo sapiens_hsa052170.71762697
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71629661
108Hedgehog signaling pathway_Homo sapiens_hsa043400.71202102
109Type I diabetes mellitus_Homo sapiens_hsa049400.71078828
110Fatty acid biosynthesis_Homo sapiens_hsa000610.71023907
111Thyroid hormone synthesis_Homo sapiens_hsa049180.70800114
112Circadian rhythm_Homo sapiens_hsa047100.70423136
113Cardiac muscle contraction_Homo sapiens_hsa042600.69861854
114Hippo signaling pathway_Homo sapiens_hsa043900.68838654
115MAPK signaling pathway_Homo sapiens_hsa040100.68160215
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67853063
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66098142
118Alzheimers disease_Homo sapiens_hsa050100.65932628
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65507552
120Bile secretion_Homo sapiens_hsa049760.64340119
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62898602
122Dorso-ventral axis formation_Homo sapiens_hsa043200.62302807
123Phototransduction_Homo sapiens_hsa047440.62292579
124Prolactin signaling pathway_Homo sapiens_hsa049170.61593235
125Pancreatic secretion_Homo sapiens_hsa049720.61416208
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61132705
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61116926
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60770998
129Ras signaling pathway_Homo sapiens_hsa040140.60425440
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59896895
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58380883
132Mineral absorption_Homo sapiens_hsa049780.57981987
133Arachidonic acid metabolism_Homo sapiens_hsa005900.57149926
134Endocytosis_Homo sapiens_hsa041440.55634194
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.55512743
136RNA polymerase_Homo sapiens_hsa030200.55501476
137Vitamin digestion and absorption_Homo sapiens_hsa049770.55253361
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54192478
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54163984
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.53908582
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53481338
142Arginine and proline metabolism_Homo sapiens_hsa003300.53235078
143Metabolic pathways_Homo sapiens_hsa011000.53069152
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52219287
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51450805
146Lysine degradation_Homo sapiens_hsa003100.51295442
147Fanconi anemia pathway_Homo sapiens_hsa034600.50969670
148Non-small cell lung cancer_Homo sapiens_hsa052230.50436746
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47473189
150Rap1 signaling pathway_Homo sapiens_hsa040150.46114941
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45826453
152Dilated cardiomyopathy_Homo sapiens_hsa054140.45212833
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44760029
154Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44319649
155AMPK signaling pathway_Homo sapiens_hsa041520.41947000
156Butanoate metabolism_Homo sapiens_hsa006500.41416781
157Regulation of autophagy_Homo sapiens_hsa041400.35770961
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35408583

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