SLC2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.14100804
2regulation of gene silencing by RNA (GO:0060966)6.96455838
3regulation of posttranscriptional gene silencing (GO:0060147)6.96455838
4regulation of gene silencing by miRNA (GO:0060964)6.96455838
5desmosome organization (GO:0002934)5.18618313
6pre-miRNA processing (GO:0031054)5.05325238
7bundle of His cell to Purkinje myocyte communication (GO:0086069)4.83627879
8paraxial mesoderm development (GO:0048339)4.78463041
9positive regulation of SMAD protein import into nucleus (GO:0060391)4.40342828
10DNA unwinding involved in DNA replication (GO:0006268)4.35163214
11nuclear pore organization (GO:0006999)4.35142486
12regulation of SMAD protein import into nucleus (GO:0060390)4.19129737
13planar cell polarity pathway involved in neural tube closure (GO:0090179)4.09287181
14nuclear pore complex assembly (GO:0051292)4.06348792
15heterochromatin organization (GO:0070828)4.02561068
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.01834376
174-hydroxyproline metabolic process (GO:0019471)4.00426851
18polarized epithelial cell differentiation (GO:0030859)3.93261373
19regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.92266039
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.91704186
21branching involved in salivary gland morphogenesis (GO:0060445)3.80002634
22regulation of hippo signaling (GO:0035330)3.76614750
23lateral sprouting from an epithelium (GO:0060601)3.75573084
24gap junction assembly (GO:0016264)3.75172497
25Notch signaling involved in heart development (GO:0061314)3.73174894
26establishment of apical/basal cell polarity (GO:0035089)3.71210385
27peptidyl-proline hydroxylation (GO:0019511)3.70183518
28regulation of gene silencing (GO:0060968)3.62450214
29establishment of planar polarity (GO:0001736)3.61888894
30establishment of tissue polarity (GO:0007164)3.61888894
31folic acid-containing compound biosynthetic process (GO:0009396)3.61807699
32anterior/posterior axis specification, embryo (GO:0008595)3.54945101
33regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.53945018
34negative regulation of keratinocyte proliferation (GO:0010839)3.53184407
35DNA replication-dependent nucleosome organization (GO:0034723)3.50015679
36DNA replication-dependent nucleosome assembly (GO:0006335)3.50015679
37cell-substrate junction assembly (GO:0007044)3.48115400
38radial glial cell differentiation (GO:0060019)3.46037595
39IMP biosynthetic process (GO:0006188)3.45802475
40negative regulation of histone methylation (GO:0031061)3.44015378
41keratinization (GO:0031424)3.43087119
42mitotic nuclear envelope disassembly (GO:0007077)3.42504655
43regulation of translational fidelity (GO:0006450)3.41921085
44hippo signaling (GO:0035329)3.33288443
45keratinocyte proliferation (GO:0043616)3.32799346
46maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32445525
47protein localization to kinetochore (GO:0034501)3.31010386
48non-canonical Wnt signaling pathway (GO:0035567)3.28240218
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.26963958
50nodal signaling pathway (GO:0038092)3.24981795
51membrane disassembly (GO:0030397)3.21844387
52nuclear envelope disassembly (GO:0051081)3.21844387
53trophectodermal cell differentiation (GO:0001829)3.21293755
54maturation of SSU-rRNA (GO:0030490)3.20593737
55regulation of establishment of planar polarity (GO:0090175)3.19840536
56negative regulation of chondrocyte differentiation (GO:0032331)3.19753662
57apoptotic process involved in morphogenesis (GO:0060561)3.18536070
58neuronal stem cell maintenance (GO:0097150)3.18322587
59regulation of histone H3-K9 methylation (GO:0051570)3.16958207
60establishment of skin barrier (GO:0061436)3.15437578
61DNA replication initiation (GO:0006270)3.14510748
62protein retention in ER lumen (GO:0006621)3.12907661
63mesodermal cell differentiation (GO:0048333)3.12829975
64protoporphyrinogen IX metabolic process (GO:0046501)3.10187800
65glycolytic process (GO:0006096)3.09406562
66convergent extension (GO:0060026)3.08312565
67protein hydroxylation (GO:0018126)3.08033297
68peptidyl-arginine omega-N-methylation (GO:0035247)3.07634180
69notochord development (GO:0030903)3.04565482
70viral transcription (GO:0019083)3.03053070
71establishment of monopolar cell polarity (GO:0061162)3.01859706
72establishment or maintenance of monopolar cell polarity (GO:0061339)3.01859706
73erythrocyte maturation (GO:0043249)3.00265483
74translational termination (GO:0006415)2.99598737
75regulation of water loss via skin (GO:0033561)2.99516784
76mitotic metaphase plate congression (GO:0007080)2.99285370
77IMP metabolic process (GO:0046040)2.99201208
78negative regulation of gene silencing (GO:0060969)2.98697300
79cell migration involved in sprouting angiogenesis (GO:0002042)2.98575752
80endothelial cell chemotaxis (GO:0035767)2.97713338
81regulation of sister chromatid cohesion (GO:0007063)2.97036439
82renal system development (GO:0072001)2.96742203
83embryonic foregut morphogenesis (GO:0048617)2.91480902
84ribosome assembly (GO:0042255)2.88706531
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.88160721
86mitotic sister chromatid segregation (GO:0000070)2.87156828
87formation of translation preinitiation complex (GO:0001731)2.86969413
88blood vessel endothelial cell migration (GO:0043534)2.86820632
89pore complex assembly (GO:0046931)2.85784163
90chromatin assembly (GO:0031497)2.85106363
91histone arginine methylation (GO:0034969)2.83932739
92histone H2A monoubiquitination (GO:0035518)2.82681806
93cranial suture morphogenesis (GO:0060363)2.80897833
94DNA duplex unwinding (GO:0032508)2.79778032
95DNA geometric change (GO:0032392)2.78936062
96embryonic heart tube development (GO:0035050)2.78699713
97negative regulation of cell fate specification (GO:0009996)2.77680486
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.75867318
99glucose 6-phosphate metabolic process (GO:0051156)2.75650940
100epidermis development (GO:0008544)2.74625199
101protein localization to chromosome, centromeric region (GO:0071459)2.74338018
102lymphangiogenesis (GO:0001946)2.73157062
103metaphase plate congression (GO:0051310)2.72878720
104regulation of keratinocyte proliferation (GO:0010837)2.72280116
105positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.71778107
106negative regulation of inclusion body assembly (GO:0090084)2.71292829
107embryonic process involved in female pregnancy (GO:0060136)2.69819352
108heart trabecula morphogenesis (GO:0061384)2.69395582
109Notch receptor processing (GO:0007220)2.69233392
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68673555
111peptidyl-arginine methylation (GO:0018216)2.68109514
112peptidyl-arginine N-methylation (GO:0035246)2.68109514
113translational initiation (GO:0006413)2.66248197
114positive regulation of chromosome segregation (GO:0051984)2.66089898
115translational elongation (GO:0006414)2.65885216
116establishment of integrated proviral latency (GO:0075713)2.65693257
117negative regulation of stem cell proliferation (GO:2000647)2.65186122
118camera-type eye morphogenesis (GO:0048593)2.65136533
119lung epithelium development (GO:0060428)2.65098549
120protein localization to cell surface (GO:0034394)2.63029552
121sister chromatid segregation (GO:0000819)2.63005532
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.62632184
123negative regulation of epidermis development (GO:0045683)2.62432030
124trophoblast giant cell differentiation (GO:0060707)2.62130013
125protein complex localization (GO:0031503)2.62068531
126regulation of translational termination (GO:0006449)2.61861083
127nucleobase biosynthetic process (GO:0046112)2.61693830
128skin morphogenesis (GO:0043589)2.61657515
129morphogenesis of an endothelium (GO:0003159)2.61613135
130endothelial tube morphogenesis (GO:0061154)2.61613135
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.61081420
132axon extension involved in axon guidance (GO:0048846)2.61081420
133craniofacial suture morphogenesis (GO:0097094)2.60731665
134ribosomal small subunit biogenesis (GO:0042274)2.59948572
135regulation of mitotic spindle organization (GO:0060236)2.59948207
136regulation of centriole replication (GO:0046599)2.59239355
137lung-associated mesenchyme development (GO:0060484)2.59163244
138regulation of cell fate specification (GO:0042659)2.58987024
139histone H4-K12 acetylation (GO:0043983)2.58900068
140ventricular trabecula myocardium morphogenesis (GO:0003222)2.57735430
141negative regulation of cartilage development (GO:0061037)2.57288741
142otic vesicle formation (GO:0030916)2.55728503
143wound healing, spreading of epidermal cells (GO:0035313)2.55558224
144hair follicle development (GO:0001942)2.55299687
145regulation of telomere maintenance via telomerase (GO:0032210)2.55277184
146cell migration involved in gastrulation (GO:0042074)2.54933943
147keratinocyte differentiation (GO:0030216)2.54580780
148regulation of helicase activity (GO:0051095)2.52999830
149DNA strand elongation involved in DNA replication (GO:0006271)2.52110386
150regulation of spindle organization (GO:0090224)2.51373578
151mitotic chromosome condensation (GO:0007076)2.50032951
152regulation of centrosome cycle (GO:0046605)2.49360932
153porphyrin-containing compound biosynthetic process (GO:0006779)2.48417493
154adherens junction assembly (GO:0034333)2.47937133
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.46376196
156lymph vessel development (GO:0001945)2.45253536
157regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.44213719
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.43928793
159regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43400753
160nuclear envelope organization (GO:0006998)2.43147666
161atrioventricular valve morphogenesis (GO:0003181)2.42476213
162placenta development (GO:0001890)2.42276112
163epithelial cell-cell adhesion (GO:0090136)2.42048621
164regulation of transforming growth factor beta2 production (GO:0032909)2.41874449
165cell fate commitment involved in formation of primary germ layer (GO:0060795)2.41796947
166lens fiber cell development (GO:0070307)2.40585641
167morphogenesis of embryonic epithelium (GO:0016331)2.40361475
168hair cycle process (GO:0022405)2.40238946
169molting cycle process (GO:0022404)2.40238946
170wound healing, spreading of cells (GO:0044319)2.39635286
171vascular endothelial growth factor signaling pathway (GO:0038084)2.39485905
172embryonic camera-type eye development (GO:0031076)2.39343318
173somatic hypermutation of immunoglobulin genes (GO:0016446)2.38907510
174somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38907510
175positive regulation of hormone biosynthetic process (GO:0046886)2.38905499
176mRNA transcription from RNA polymerase II promoter (GO:0042789)2.38256005
177negative regulation of cell fate commitment (GO:0010454)2.37944109
178regulation of cholesterol homeostasis (GO:2000188)2.37654388
179regulation of hair follicle development (GO:0051797)2.37463628
180morphogenesis of an epithelial sheet (GO:0002011)2.36322104
181protoporphyrinogen IX biosynthetic process (GO:0006782)2.35233873
182vasculature development (GO:0001944)2.33518909
183regulation of G0 to G1 transition (GO:0070316)2.32377126
184endothelial cell differentiation (GO:0045446)2.32136946
185dorsal/ventral axis specification (GO:0009950)2.31379956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60466674
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.06111806
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.68461982
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.63923572
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.63923572
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.63923572
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.44749270
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.26573729
9* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.96117719
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93067445
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71533372
12ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.68384180
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67921763
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.63267843
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.53572542
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.53397412
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.53048068
18* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.41550981
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34213019
20* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29486385
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25458496
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05913407
23SOX2_18555785_ChIP-Seq_MESCs_Mouse2.04850611
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.04625273
25AR_21909140_ChIP-Seq_LNCAP_Human2.03823196
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.02123574
27TCF3_18692474_ChIP-Seq_MESCs_Mouse1.98399209
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94021216
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92795224
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89466313
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.82900225
32XRN2_22483619_ChIP-Seq_HELA_Human1.80589975
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80175319
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77378892
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77000701
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.75687802
37ZNF263_19887448_ChIP-Seq_K562_Human1.72711391
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67135102
39KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.63861206
40NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60582385
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59136747
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58673017
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.56490891
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54482361
45* MYC_22102868_ChIP-Seq_BL_Human1.54398667
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54280980
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54077675
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53965256
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.53752632
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48614260
51SOX2_18692474_ChIP-Seq_MEFs_Mouse1.45195906
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.45006427
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41751138
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41333217
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.41322377
56POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40015447
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36424616
58* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35302810
59* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34928878
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34663285
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.34522203
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34368351
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34114239
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33424335
65TTF2_22483619_ChIP-Seq_HELA_Human1.32901759
66* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.32719176
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31150677
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27545444
69TP53_22127205_ChIP-Seq_IMR90_Human1.26993904
70* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26857453
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26762214
72SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26011249
73* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26005729
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24473762
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24273770
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.23264986
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.22607241
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.21553642
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20795054
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19132167
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18929838
82SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18929838
83* RACK7_27058665_Chip-Seq_MCF-7_Human1.17309278
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16179798
85* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16173324
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15768418
87* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15112599
88* KDM2B_26808549_Chip-Seq_K562_Human1.14832498
89* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14709863
90ATF3_27146783_Chip-Seq_COLON_Human1.14093959
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14091493
92* ESR2_21235772_ChIP-Seq_MCF-7_Human1.13727517
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12754747
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11569645
95CLOCK_20551151_ChIP-Seq_293T_Human1.10797452
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10601706
97PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10366274
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10127031
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09568852
100* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08722887
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.07805214
102* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07410159
103SOX2_16153702_ChIP-ChIP_HESCs_Human1.06732111
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06681949
105EST1_17652178_ChIP-ChIP_JURKAT_Human1.06554714
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06288864
107ISL1_27105846_Chip-Seq_CPCs_Mouse1.04343992
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03858222
109ETS1_20019798_ChIP-Seq_JURKAT_Human1.03076571
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.02982324
111* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01280460
112ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01016055
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00614905
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99831420
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98716305
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97702375
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97514038
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97360894
119* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.97278688
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95538385
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93869438
122* KDM2B_26808549_Chip-Seq_DND41_Human0.92375207
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91967991
124TFEB_21752829_ChIP-Seq_HELA_Human0.91235241
125TP53_20018659_ChIP-ChIP_R1E_Mouse0.90737964
126* CHD1_26751641_Chip-Seq_LNCaP_Human0.90316151
127KDM5A_27292631_Chip-Seq_BREAST_Human0.90271414
128TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88407377
129* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87308897
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86693522
131* SOX17_20123909_ChIP-Seq_XEN_Mouse0.86576308
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.85264617
133* GATA1_19941826_ChIP-Seq_K562_Human0.84845939
134LXR_22292898_ChIP-Seq_THP-1_Human0.84788976
135RING1B_27294783_Chip-Seq_NPCs_Mouse0.84593770
136* KAP1_27257070_Chip-Seq_ESCs_Mouse0.84406453
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.83022640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology4.48823502
2MP0000566_synostosis3.53903684
3MP0003123_paternal_imprinting2.88447497
4MP0004957_abnormal_blastocyst_morpholog2.66588965
5MP0010030_abnormal_orbit_morphology2.55942646
6MP0005409_darkened_coat_color2.54542409
7MP0004272_abnormal_basement_membrane2.54334888
8MP0003111_abnormal_nucleus_morphology2.51948951
9MP0004147_increased_porphyrin_level2.51670192
10MP0005257_abnormal_intraocular_pressure2.49294998
11MP0010352_gastrointestinal_tract_polyps2.48045325
12MP0002653_abnormal_ependyma_morphology2.42252430
13MP0003122_maternal_imprinting2.37318735
14MP0003121_genomic_imprinting2.36132563
15MP0001730_embryonic_growth_arrest2.28737068
16MP0000537_abnormal_urethra_morphology2.28581805
17MP0005076_abnormal_cell_differentiation2.27237133
18MP0003705_abnormal_hypodermis_morpholog2.25235259
19MP0003077_abnormal_cell_cycle2.23857278
20MP0003941_abnormal_skin_development2.22552175
21MP0004133_heterotaxia2.17412994
22MP0005623_abnormal_meninges_morphology2.13992964
23MP0002098_abnormal_vibrissa_morphology2.09150541
24MP0003693_abnormal_embryo_hatching2.08750714
25MP0002084_abnormal_developmental_patter2.05802032
26MP0010094_abnormal_chromosome_stability2.04087673
27MP0003566_abnormal_cell_adhesion2.04049925
28MP0002086_abnormal_extraembryonic_tissu1.99317589
29MP0010234_abnormal_vibrissa_follicle1.98499402
30* MP0005380_embryogenesis_phenotype1.92844272
31* MP0001672_abnormal_embryogenesis/_devel1.92844272
32MP0004197_abnormal_fetal_growth/weight/1.89179716
33MP0003119_abnormal_digestive_system1.85802665
34* MP0003984_embryonic_growth_retardation1.85695678
35* MP0002088_abnormal_embryonic_growth/wei1.83839958
36MP0001293_anophthalmia1.83690554
37MP0002085_abnormal_embryonic_tissue1.82309635
38* MP0001697_abnormal_embryo_size1.78750630
39MP0001849_ear_inflammation1.76220573
40MP0004264_abnormal_extraembryonic_tissu1.75950623
41MP0003567_abnormal_fetal_cardiomyocyte1.74115296
42MP0008932_abnormal_embryonic_tissue1.74041416
43MP0008007_abnormal_cellular_replicative1.73033673
44MP0000350_abnormal_cell_proliferation1.72681556
45MP0003890_abnormal_embryonic-extraembry1.72338782
46MP0000467_abnormal_esophagus_morphology1.66847783
47MP0005275_abnormal_skin_tensile1.63934926
48MP0002697_abnormal_eye_size1.62500780
49MP0002060_abnormal_skin_morphology1.59409411
50MP0003937_abnormal_limbs/digits/tail_de1.48642632
51MP0000383_abnormal_hair_follicle1.46759206
52MP0009053_abnormal_anal_canal1.46131277
53MP0005167_abnormal_blood-brain_barrier1.45451386
54* MP0002080_prenatal_lethality1.45082242
55MP0002925_abnormal_cardiovascular_devel1.43212565
56MP0009379_abnormal_foot_pigmentation1.43064812
57MP0006292_abnormal_olfactory_placode1.42025710
58MP0001216_abnormal_epidermal_layer1.40518656
59MP0008057_abnormal_DNA_replication1.38759682
60MP0001299_abnormal_eye_distance/1.36112577
61MP0005023_abnormal_wound_healing1.31888891
62MP0004885_abnormal_endolymph1.31866616
63MP0001286_abnormal_eye_development1.29951700
64MP0001915_intracranial_hemorrhage1.29040592
65MP0005367_renal/urinary_system_phenotyp1.28399899
66MP0000516_abnormal_urinary_system1.28399899
67MP0008438_abnormal_cutaneous_collagen1.27553368
68MP0010307_abnormal_tumor_latency1.25764691
69MP0010771_integument_phenotype1.25295738
70MP0008789_abnormal_olfactory_epithelium1.23517901
71MP0003283_abnormal_digestive_organ1.23117729
72MP0002127_abnormal_cardiovascular_syste1.22382914
73MP0002233_abnormal_nose_morphology1.20843393
74MP0002092_abnormal_eye_morphology1.20709968
75MP0005499_abnormal_olfactory_system1.20497319
76MP0005394_taste/olfaction_phenotype1.20497319
77MP0003950_abnormal_plasma_membrane1.19971460
78MP0000377_abnormal_hair_follicle1.18123817
79MP0005083_abnormal_biliary_tract1.17188310
80MP0004084_abnormal_cardiac_muscle1.16953606
81MP0000428_abnormal_craniofacial_morphol1.14993548
82MP0002111_abnormal_tail_morphology1.14047790
83MP0000049_abnormal_middle_ear1.13113899
84MP0005501_abnormal_skin_physiology1.12740885
85MP0003656_abnormal_erythrocyte_physiolo1.12540471
86MP0000432_abnormal_head_morphology1.08731059
87MP0005197_abnormal_uvea_morphology1.08612513
88MP0000733_abnormal_muscle_development1.07594871
89MP0002249_abnormal_larynx_morphology1.06886733
90MP0010368_abnormal_lymphatic_system1.05278697
91MP0001879_abnormal_lymphatic_vessel1.05209069
92MP0004233_abnormal_muscle_weight1.05087015
93MP0003136_yellow_coat_color1.04481011
94MP0008260_abnormal_autophagy1.04231038
95MP0002938_white_spotting1.03481692
96MP0003385_abnormal_body_wall1.03406462
97MP0003861_abnormal_nervous_system1.02181860
98MP0003935_abnormal_craniofacial_develop1.02022161
99MP0000647_abnormal_sebaceous_gland1.01966169
100MP0000762_abnormal_tongue_morphology1.01517752
101MP0010630_abnormal_cardiac_muscle0.97957707
102MP0006054_spinal_hemorrhage0.97774684
103MP0002282_abnormal_trachea_morphology0.97758534
104MP0002234_abnormal_pharynx_morphology0.97492446
105MP0009278_abnormal_bone_marrow0.95445826
106MP0009384_cardiac_valve_regurgitation0.94332154
107MP0009672_abnormal_birth_weight0.92631964
108MP0001614_abnormal_blood_vessel0.91571414
109MP0000534_abnormal_ureter_morphology0.91234144
110MP0009703_decreased_birth_body0.91074803
111MP0000266_abnormal_heart_morphology0.90071089
112MP0003755_abnormal_palate_morphology0.89554624
113MP0003453_abnormal_keratinocyte_physiol0.87546122
114MP0009931_abnormal_skin_appearance0.87448326
115MP0001340_abnormal_eyelid_morphology0.87408123
116MP0001529_abnormal_vocalization0.86815833
117MP0003115_abnormal_respiratory_system0.86371801
118MP0000778_abnormal_nervous_system0.86255272
119MP0002796_impaired_skin_barrier0.85855627
120MP0008058_abnormal_DNA_repair0.85045786
121MP0003091_abnormal_cell_migration0.85026809
122MP0003878_abnormal_ear_physiology0.83345634
123MP0005377_hearing/vestibular/ear_phenot0.83345634
124MP0001784_abnormal_fluid_regulation0.79805277
125MP0005391_vision/eye_phenotype0.79688714
126MP0002116_abnormal_craniofacial_bone0.78492647
127MP0008770_decreased_survivor_rate0.78389455
128MP0005193_abnormal_anterior_eye0.78156539
129MP0000313_abnormal_cell_death0.76634783
130MP0005248_abnormal_Harderian_gland0.75679590
131MP0002295_abnormal_pulmonary_circulatio0.74734882
132MP0008775_abnormal_heart_ventricle0.74492887
133MP0004858_abnormal_nervous_system0.73817325
134MP0003279_aneurysm0.71929293
135MP0003315_abnormal_perineum_morphology0.71224084
136MP0002089_abnormal_postnatal_growth/wei0.71154569
137MP0003942_abnormal_urinary_system0.70137460
138MP0002332_abnormal_exercise_endurance0.69988467
139MP0000750_abnormal_muscle_regeneration0.69073730
140MP0000767_abnormal_smooth_muscle0.68400485
141MP0010678_abnormal_skin_adnexa0.67287670

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.12430153
2Fragile nails (HP:0001808)4.86730299
3Onycholysis (HP:0001806)4.53093186
4Milia (HP:0001056)4.10032564
5Pterygium (HP:0001059)3.64447881
6Atrophic scars (HP:0001075)3.61247976
7Plantar hyperkeratosis (HP:0007556)3.61079452
8Selective tooth agenesis (HP:0001592)3.57492574
9Esophageal atresia (HP:0002032)3.55039935
10Absent eyelashes (HP:0000561)3.53346447
11Ependymoma (HP:0002888)3.47322725
12Woolly hair (HP:0002224)3.36860157
13Hypotrichosis (HP:0001006)3.35915494
14Missing ribs (HP:0000921)3.21611448
15Aplasia/hypoplasia of the humerus (HP:0006507)3.13138365
16Short humerus (HP:0005792)3.10537410
17Abdominal situs inversus (HP:0003363)3.02519287
18Abnormality of abdominal situs (HP:0011620)3.02519287
19Right ventricular cardiomyopathy (HP:0011663)3.01510999
20Supernumerary spleens (HP:0009799)2.99932841
21Thick nail (HP:0001805)2.98545533
22Colon cancer (HP:0003003)2.97678084
23Stenosis of the external auditory canal (HP:0000402)2.97105389
24Absent radius (HP:0003974)2.95757429
25Premature rupture of membranes (HP:0001788)2.94135043
26Coronal craniosynostosis (HP:0004440)2.90202617
27Aplasia involving forearm bones (HP:0009822)2.87174431
28Absent forearm bone (HP:0003953)2.87174431
29Deviation of the thumb (HP:0009603)2.85254766
30Ridged nail (HP:0001807)2.83691926
31Cholecystitis (HP:0001082)2.78948688
32Abnormal gallbladder physiology (HP:0012438)2.78948688
33Aplasia involving bones of the extremities (HP:0009825)2.78828471
34Aplasia involving bones of the upper limbs (HP:0009823)2.78828471
35Aplasia of the phalanges of the hand (HP:0009802)2.78828471
36Exercise-induced muscle cramps (HP:0003710)2.74227232
37Natal tooth (HP:0000695)2.73013298
38Skull defect (HP:0001362)2.69361046
39Alopecia of scalp (HP:0002293)2.66055448
40* Reticulocytosis (HP:0001923)2.64949559
41Fused cervical vertebrae (HP:0002949)2.64323414
42Palmoplantar hyperkeratosis (HP:0000972)2.60556080
43Proximal placement of thumb (HP:0009623)2.56435105
44Astrocytoma (HP:0009592)2.54683244
45Abnormality of the astrocytes (HP:0100707)2.54683244
46Medulloblastoma (HP:0002885)2.51167061
47Abnormal number of incisors (HP:0011064)2.50987663
48Nail dystrophy (HP:0008404)2.50879107
49Palmar hyperkeratosis (HP:0010765)2.50413304
50Rib fusion (HP:0000902)2.46702875
51* Abnormality of reticulocytes (HP:0004312)2.43023003
52Gastrointestinal atresia (HP:0002589)2.38601225
53Abnormality of the labia minora (HP:0012880)2.35527198
54Small epiphyses (HP:0010585)2.34144581
55Gastrointestinal carcinoma (HP:0002672)2.32511145
56Malignant gastrointestinal tract tumors (HP:0006749)2.32511145
57Neonatal short-limb short stature (HP:0008921)2.32111120
58Anophthalmia (HP:0000528)2.32099646
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.30799257
60Vertebral hypoplasia (HP:0008417)2.30799257
61Partial duplication of thumb phalanx (HP:0009944)2.27277966
6211 pairs of ribs (HP:0000878)2.25645126
63Broad thumb (HP:0011304)2.25093634
64Absent epiphyses (HP:0010577)2.23831318
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.23831318
66Neoplasm of the oral cavity (HP:0100649)2.23208951
67Breast hypoplasia (HP:0003187)2.23017872
68Pseudobulbar signs (HP:0002200)2.20375472
69Aplasia/Hypoplasia of the spleen (HP:0010451)2.16399968
70Absent eyebrow (HP:0002223)2.15494324
71Advanced eruption of teeth (HP:0006288)2.14558421
72Shallow orbits (HP:0000586)2.14225934
73Adactyly (HP:0009776)2.13694898
74Vertebral fusion (HP:0002948)2.13367824
75Pili torti (HP:0003777)2.12510376
76Reticulocytopenia (HP:0001896)2.11533848
77Metaphyseal cupping (HP:0003021)2.10883445
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.10373883
79Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09489053
80High anterior hairline (HP:0009890)2.07010686
81Insomnia (HP:0100785)2.06743489
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.05352711
83Flattened epiphyses (HP:0003071)2.04810074
84Preauricular skin tag (HP:0000384)2.04601821
85Anal stenosis (HP:0002025)2.04434592
86Agnosia (HP:0010524)2.03099306
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02918103
88Short 4th metacarpal (HP:0010044)2.02918103
89Breast aplasia (HP:0100783)2.02805052
90Supernumerary ribs (HP:0005815)2.02519817
91Cervical subluxation (HP:0003308)2.02066510
92Asplenia (HP:0001746)2.01645430
93Skin tags (HP:0010609)2.00111761
94Hemivertebrae (HP:0002937)2.00050079
95Ulnar bowing (HP:0003031)1.99631216
96Vertebral clefting (HP:0008428)1.99307786
97Biliary tract neoplasm (HP:0100574)1.98759858
98Septo-optic dysplasia (HP:0100842)1.98278944
99Flat acetabular roof (HP:0003180)1.97689822
100Abnormal blistering of the skin (HP:0008066)1.97594311
101Abnormal lung lobation (HP:0002101)1.94979153
102Fragile skin (HP:0001030)1.94574149
103Shawl scrotum (HP:0000049)1.94539258
104Abnormal vertebral ossification (HP:0100569)1.94293232
105Partial duplication of the phalanx of hand (HP:0009999)1.93103043
106Diaphragmatic weakness (HP:0009113)1.91925687
107Sparse scalp hair (HP:0002209)1.91854794
108Glioma (HP:0009733)1.91698236
109Rhabdomyosarcoma (HP:0002859)1.91237992
110Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90469334
111Supernumerary bones of the axial skeleton (HP:0009144)1.89072928
112Protrusio acetabuli (HP:0003179)1.88540520
113Short nail (HP:0001799)1.88347480
114Absent hair (HP:0002298)1.88276481
115Absent toe (HP:0010760)1.87861741
116Duplication of thumb phalanx (HP:0009942)1.86397655
117Aplasia/Hypoplasia of the breasts (HP:0010311)1.85030982
118Trigonocephaly (HP:0000243)1.83745677
119Hypoplastic pelvis (HP:0008839)1.82878027
120Hypodontia (HP:0000668)1.82522639
121Arterial tortuosity (HP:0005116)1.82322791
122Abnormality of dentin (HP:0010299)1.81077921
123Broad phalanges of the hand (HP:0009768)1.80894716
124Carpal bone hypoplasia (HP:0001498)1.80072167
125Trismus (HP:0000211)1.79389303
126Neoplasm of striated muscle (HP:0009728)1.78715916
127Renal duplication (HP:0000075)1.78650530
128Atresia of the external auditory canal (HP:0000413)1.78222249
129Abnormality of the lacrimal duct (HP:0011481)1.76218733
130Corneal erosion (HP:0200020)1.74693544
131Short phalanx of the thumb (HP:0009660)1.74012114
132Vertebral arch anomaly (HP:0008438)1.73373383
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.72827604
134Patellar aplasia (HP:0006443)1.71437336
135Poikilocytosis (HP:0004447)1.71225729
136Short 1st metacarpal (HP:0010034)1.71193740
137Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.71193740
138Abnormality of the fetal cardiovascular system (HP:0010948)1.70985513
139Abnormal umbilical cord blood vessels (HP:0011403)1.70985513
140Single umbilical artery (HP:0001195)1.70985513
141Limited elbow extension (HP:0001377)1.70848947
142Broad toe (HP:0001837)1.70704886
143Esophageal varix (HP:0002040)1.70671388
144Vascular tortuosity (HP:0004948)1.69977343
145Hypoplasia of dental enamel (HP:0006297)1.69885233
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.69836127
147Broad palm (HP:0001169)1.69610448
148Increased nuchal translucency (HP:0010880)1.68666467
149Ankyloglossia (HP:0010296)1.67511256
150Bronchomalacia (HP:0002780)1.66817485
151Basal cell carcinoma (HP:0002671)1.66179660
152Epidermoid cyst (HP:0200040)1.65893340
153Anonychia (HP:0001798)1.65880136
154Abnormality of carpal bone ossification (HP:0006257)1.64834845
155Aplasia cutis congenita (HP:0001057)1.64354652
156Neoplasm of the pancreas (HP:0002894)1.64058605
157Abnormality of permanent molar morphology (HP:0011071)1.63772993
158Abnormality of the dental root (HP:0006486)1.63772993
159Taurodontia (HP:0000679)1.63772993
160Uterine neoplasm (HP:0010784)1.63698096
161Rectal fistula (HP:0100590)1.63645915
162Rectovaginal fistula (HP:0000143)1.63645915
163Broad face (HP:0000283)1.63326828
164Nasolacrimal duct obstruction (HP:0000579)1.63213241
165Abnormal hair laboratory examination (HP:0003328)1.62629387
166Oral leukoplakia (HP:0002745)1.61133333
167Maternal diabetes (HP:0009800)1.60416132
168Hydroureter (HP:0000072)1.60122560
169Pancreatic islet-cell hyperplasia (HP:0004510)1.60086668
170Abnormality of the nasal septum (HP:0000419)1.60050112
171Abnormality of the salivary glands (HP:0010286)1.60044318
172Sparse eyelashes (HP:0000653)1.59690324
173Abnormal tarsal ossification (HP:0008369)1.59512174
174Broad finger (HP:0001500)1.59248050
175Aplasia/Hypoplasia of the patella (HP:0006498)1.58504875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.99900793
2EPHA23.78312324
3RPS6KB23.06603787
4CDC72.91357559
5MAPK152.60702811
6SIK12.55394962
7BUB12.47353158
8WEE12.46470650
9KDR2.43644228
10PKN22.40959177
11MST1R2.30007751
12STK102.29934771
13EEF2K2.14498766
14NEK12.06445981
15TSSK61.98727326
16NTRK11.91843148
17PAK41.86707298
18BRD41.77940780
19NEK21.75667952
20TTK1.75264356
21SMG11.69080470
22MAP3K81.67105241
23PLK41.65617159
24PNCK1.52144405
25MET1.49161666
26ALK1.47918235
27CDK71.46583172
28MAP3K101.44072356
29MKNK11.43087164
30EPHA41.42206744
31LATS21.41378816
32LRRK21.40946946
33ARAF1.36751501
34VRK21.35973858
35FGFR11.33349044
36MAP2K21.33272086
37TGFBR11.33076823
38MAP3K91.31032787
39PLK31.25241881
40BMX1.22252740
41SCYL21.20425179
42CDK61.20114136
43PLK11.19077454
44TESK21.17586794
45MTOR1.16840821
46AURKB1.15140782
47PTK21.14645376
48FLT31.11171438
49MAPKAPK31.08279634
50PASK1.07858777
51LATS11.07831258
52PAK21.06083823
53CHEK11.05678160
54AKT21.05187959
55DYRK1B1.03015271
56MKNK21.02291464
57AKT31.00583232
58CDK41.00230879
59MAP3K20.95847683
60AURKA0.94833076
61PTK60.92476826
62ICK0.90382021
63PBK0.89518244
64EPHB20.89296931
65STK390.89177487
66EIF2AK10.86553360
67MELK0.86378444
68ERBB40.84999552
69VRK10.83680947
70LMTK20.83068191
71STK38L0.82445664
72MST40.81099850
73SRPK10.80769805
74WNK40.78690713
75CHEK20.77882316
76STK40.77684503
77CDK20.77173152
78RPS6KA40.77067799
79PDGFRA0.75119649
80BCR0.74683318
81STK30.74347998
82ATM0.74267280
83STK240.72178429
84ATR0.71874618
85PAK10.71574085
86FER0.71495355
87PIM10.70509722
88LIMK10.70507772
89TESK10.70213575
90FGFR40.69077025
91TIE10.68981129
92CDK80.66601421
93PRKG20.66388787
94KSR20.65733309
95BRSK20.65700695
96CSNK1D0.64737637
97DDR20.63168392
98CSNK1E0.61570814
99CAMK1D0.60185451
100MOS0.59707760
101PIM20.59612149
102MAP3K30.59580889
103DMPK0.59127912
104PRKCI0.58465748
105RIPK10.57625974
106BCKDK0.56937939
107IRAK30.56471765
108TLK10.55355760
109MARK30.54837669
110NME10.54757650
111CDK10.52147052
112TTN0.50260980
113TYRO30.49249623
114GSK3A0.48428444
115PRKD20.47580388
116DAPK30.47086621
117CSNK2A20.44821287
118FGR0.43905731
119PRKDC0.43546618
120ROCK20.43486382
121DYRK30.43067923
122AKT10.42975650
123PRKD30.41917741
124DYRK20.41720580
125TAF10.41597212
126MAP3K70.41208026
127PIK3CA0.40951897
128MAP2K10.39858822
129OBSCN0.39796250
130MAPK10.39087549
131CDK90.37127388
132MAPKAPK50.36838166
133WNK10.36707488
134BRSK10.36681450
135TAOK20.36354101
136BRAF0.35756270
137STK380.35368926
138RPS6KL10.35130186
139RPS6KC10.35130186
140KSR10.33068058
141RPS6KA50.32129672
142RPS6KA20.32058518
143NME20.31894377
144ERBB20.29270407
145EPHB10.27331577

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.35702268
2DNA replication_Homo sapiens_hsa030302.99393217
3Mismatch repair_Homo sapiens_hsa034302.96442204
4Spliceosome_Homo sapiens_hsa030402.77717703
5RNA transport_Homo sapiens_hsa030132.66445353
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60434838
7Steroid biosynthesis_Homo sapiens_hsa001002.54385069
8Hippo signaling pathway_Homo sapiens_hsa043902.44942927
9Adherens junction_Homo sapiens_hsa045202.39335179
10One carbon pool by folate_Homo sapiens_hsa006702.35267037
11Basal cell carcinoma_Homo sapiens_hsa052172.35037683
12Cell cycle_Homo sapiens_hsa041102.34435831
13Ribosome_Homo sapiens_hsa030102.30023803
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17394363
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.02465937
16Nucleotide excision repair_Homo sapiens_hsa034201.89870833
17mRNA surveillance pathway_Homo sapiens_hsa030151.82586365
18Tight junction_Homo sapiens_hsa045301.78854477
19TGF-beta signaling pathway_Homo sapiens_hsa043501.75456661
20Hedgehog signaling pathway_Homo sapiens_hsa043401.71156457
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70380341
22MicroRNAs in cancer_Homo sapiens_hsa052061.70061491
23Bladder cancer_Homo sapiens_hsa052191.56816845
24Base excision repair_Homo sapiens_hsa034101.56795870
25Homologous recombination_Homo sapiens_hsa034401.54056475
26RNA polymerase_Homo sapiens_hsa030201.52008018
27Thyroid cancer_Homo sapiens_hsa052161.49289873
28p53 signaling pathway_Homo sapiens_hsa041151.48743855
29RNA degradation_Homo sapiens_hsa030181.46998510
30Proteoglycans in cancer_Homo sapiens_hsa052051.46752645
31Notch signaling pathway_Homo sapiens_hsa043301.46542144
32Prion diseases_Homo sapiens_hsa050201.44890341
33* HIF-1 signaling pathway_Homo sapiens_hsa040661.43369859
34Small cell lung cancer_Homo sapiens_hsa052221.40188121
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35444918
36* Central carbon metabolism in cancer_Homo sapiens_hsa052301.27759733
37Carbon metabolism_Homo sapiens_hsa012001.23661092
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22728171
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21663749
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21321587
41Focal adhesion_Homo sapiens_hsa045101.20892567
42N-Glycan biosynthesis_Homo sapiens_hsa005101.20110958
43ECM-receptor interaction_Homo sapiens_hsa045121.18044517
44Wnt signaling pathway_Homo sapiens_hsa043101.16935183
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16649277
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15139699
47Biosynthesis of amino acids_Homo sapiens_hsa012301.13839146
48Viral carcinogenesis_Homo sapiens_hsa052031.13579171
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.12472453
50* HTLV-I infection_Homo sapiens_hsa051661.11264337
51Fanconi anemia pathway_Homo sapiens_hsa034601.10512171
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.07398645
53Oocyte meiosis_Homo sapiens_hsa041141.07329046
54* Pathways in cancer_Homo sapiens_hsa052001.07126201
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06993203
56Nitrogen metabolism_Homo sapiens_hsa009101.05295186
57Colorectal cancer_Homo sapiens_hsa052101.04788021
58Systemic lupus erythematosus_Homo sapiens_hsa053221.02207879
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98392401
60Protein digestion and absorption_Homo sapiens_hsa049740.95360026
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93555113
62Rap1 signaling pathway_Homo sapiens_hsa040150.93277110
63Prostate cancer_Homo sapiens_hsa052150.92842444
64Chronic myeloid leukemia_Homo sapiens_hsa052200.91545813
65Arginine and proline metabolism_Homo sapiens_hsa003300.91518605
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90525273
67Basal transcription factors_Homo sapiens_hsa030220.89204201
68Melanoma_Homo sapiens_hsa052180.88812294
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88661049
70Vitamin B6 metabolism_Homo sapiens_hsa007500.87496316
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85844856
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84974621
73* Renal cell carcinoma_Homo sapiens_hsa052110.84514839
74Epstein-Barr virus infection_Homo sapiens_hsa051690.83574576
75Melanogenesis_Homo sapiens_hsa049160.83418043
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82764390
77Pyrimidine metabolism_Homo sapiens_hsa002400.80112491
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78784993
79Non-homologous end-joining_Homo sapiens_hsa034500.78028816
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77611534
81Proteasome_Homo sapiens_hsa030500.77205314
82mTOR signaling pathway_Homo sapiens_hsa041500.75035305
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74180028
84Endometrial cancer_Homo sapiens_hsa052130.71175936
85* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66697514
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64072108
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61471938
88ErbB signaling pathway_Homo sapiens_hsa040120.60394973
89Apoptosis_Homo sapiens_hsa042100.58943879
90Thyroid hormone synthesis_Homo sapiens_hsa049180.57824175
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57774603
92Dorso-ventral axis formation_Homo sapiens_hsa043200.56670308
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56074689
94Protein export_Homo sapiens_hsa030600.55413987
95Alcoholism_Homo sapiens_hsa050340.54159606
96Folate biosynthesis_Homo sapiens_hsa007900.53932997
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.53734064
98VEGF signaling pathway_Homo sapiens_hsa043700.52925937
99Dilated cardiomyopathy_Homo sapiens_hsa054140.52499425
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51784997
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.51582002
102AMPK signaling pathway_Homo sapiens_hsa041520.50933850
103Herpes simplex infection_Homo sapiens_hsa051680.50014287
104Amoebiasis_Homo sapiens_hsa051460.48667012
105Viral myocarditis_Homo sapiens_hsa054160.47859037
106Glutathione metabolism_Homo sapiens_hsa004800.46983566
107Fructose and mannose metabolism_Homo sapiens_hsa000510.45513219
108Shigellosis_Homo sapiens_hsa051310.45315735
109Antigen processing and presentation_Homo sapiens_hsa046120.44191013
110Legionellosis_Homo sapiens_hsa051340.43230591
111Fatty acid elongation_Homo sapiens_hsa000620.42426732
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.41829777
113Glioma_Homo sapiens_hsa052140.41298313
114Axon guidance_Homo sapiens_hsa043600.40854500
115FoxO signaling pathway_Homo sapiens_hsa040680.40696278
116Starch and sucrose metabolism_Homo sapiens_hsa005000.40040142
117Estrogen signaling pathway_Homo sapiens_hsa049150.39506740
118Pancreatic cancer_Homo sapiens_hsa052120.38754546
119Arginine biosynthesis_Homo sapiens_hsa002200.38546490
120Sulfur relay system_Homo sapiens_hsa041220.38110539
121Ras signaling pathway_Homo sapiens_hsa040140.36615228
122Gap junction_Homo sapiens_hsa045400.36469282
123MAPK signaling pathway_Homo sapiens_hsa040100.36198184
124Purine metabolism_Homo sapiens_hsa002300.35791665
125Pyruvate metabolism_Homo sapiens_hsa006200.35772826
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35686830
127Circadian rhythm_Homo sapiens_hsa047100.35237879
128Galactose metabolism_Homo sapiens_hsa000520.33026958
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.32866665
130Mineral absorption_Homo sapiens_hsa049780.32440032
131Acute myeloid leukemia_Homo sapiens_hsa052210.31755743
132Endocytosis_Homo sapiens_hsa041440.30283433
133Non-small cell lung cancer_Homo sapiens_hsa052230.30135865
134Choline metabolism in cancer_Homo sapiens_hsa052310.30088903
135* Bile secretion_Homo sapiens_hsa049760.30028058
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28423099
137Lysine degradation_Homo sapiens_hsa003100.28327886
138Pentose phosphate pathway_Homo sapiens_hsa000300.28157361
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27977751

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