SLC2A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.35503258
2positive regulation of extracellular matrix organization (GO:1903055)4.94870733
3notochord development (GO:0030903)4.84316323
4maintenance of gastrointestinal epithelium (GO:0030277)4.79143740
5dermatan sulfate biosynthetic process (GO:0030208)4.77548262
6sequestering of extracellular ligand from receptor (GO:0035581)4.73957834
7dermatan sulfate metabolic process (GO:0030205)4.71502134
8blood vessel maturation (GO:0001955)4.65015946
9cell aggregation (GO:0098743)4.45528973
10cartilage condensation (GO:0001502)4.45528973
11cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.39119718
12chondrocyte proliferation (GO:0035988)4.34836182
13fibril organization (GO:0097435)4.26956023
14extracellular fibril organization (GO:0043206)4.14291197
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.08141861
16positive regulation of cellular amide metabolic process (GO:0034250)4.07491503
17protein heterotrimerization (GO:0070208)3.99936838
18chondroitin sulfate biosynthetic process (GO:0030206)3.93666688
19mesenchyme morphogenesis (GO:0072132)3.86742044
20protein retention in ER lumen (GO:0006621)3.83231345
21bone trabecula formation (GO:0060346)3.78990686
22chondrocyte development (GO:0002063)3.76828660
23endocardial cushion morphogenesis (GO:0003203)3.74726774
24protein carboxylation (GO:0018214)3.68223923
25peptidyl-glutamic acid carboxylation (GO:0017187)3.68223923
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67689700
27skin morphogenesis (GO:0043589)3.61091473
28keratan sulfate catabolic process (GO:0042340)3.54055817
29basement membrane organization (GO:0071711)3.50885552
30tooth mineralization (GO:0034505)3.49536060
31regulation of metalloenzyme activity (GO:0048552)3.48676893
32peripheral nervous system axon ensheathment (GO:0032292)3.41385582
33myelination in peripheral nervous system (GO:0022011)3.41385582
34negative regulation of fibrinolysis (GO:0051918)3.40263582
35regulation of protein activation cascade (GO:2000257)3.40096139
36collagen metabolic process (GO:0032963)3.37266770
37primary alcohol catabolic process (GO:0034310)3.36136815
38axonemal dynein complex assembly (GO:0070286)3.36131779
39epithelial structure maintenance (GO:0010669)3.34955270
40collagen catabolic process (GO:0030574)3.34534195
41limb bud formation (GO:0060174)3.34033619
42negative regulation of chondrocyte differentiation (GO:0032331)3.33497295
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.32823207
44kidney mesenchyme development (GO:0072074)3.31481378
45metanephric mesenchyme development (GO:0072075)3.31077902
46regulation of fibrinolysis (GO:0051917)3.30725001
47regulation of complement activation (GO:0030449)3.30233077
48negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.30200834
49type B pancreatic cell proliferation (GO:0044342)3.29675592
50positive regulation of chondrocyte differentiation (GO:0032332)3.26406339
51cell proliferation involved in metanephros development (GO:0072203)3.25849569
52endothelial cell morphogenesis (GO:0001886)3.25550366
53mesenchymal-epithelial cell signaling (GO:0060638)3.23009980
54complement activation, alternative pathway (GO:0006957)3.21834301
55endodermal cell differentiation (GO:0035987)3.20205971
56regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19347401
57cartilage development (GO:0051216)3.19230472
58endocardial cushion development (GO:0003197)3.17015904
59negative regulation of cartilage development (GO:0061037)3.16233006
60multicellular organismal catabolic process (GO:0044243)3.15885698
61ethanol metabolic process (GO:0006067)3.13814569
62regulation of axon extension involved in axon guidance (GO:0048841)3.12566592
63positive regulation of stem cell differentiation (GO:2000738)3.12181645
64glomerular basement membrane development (GO:0032836)3.11925226
65multicellular organismal macromolecule metabolic process (GO:0044259)3.11662198
66peptidyl-proline hydroxylation (GO:0019511)3.11441937
67positive regulation of cartilage development (GO:0061036)3.09963469
68regulation of extracellular matrix organization (GO:1903053)3.07435776
69negative regulation of astrocyte differentiation (GO:0048712)3.05872658
70multicellular organismal metabolic process (GO:0044236)3.04600366
71lipopolysaccharide biosynthetic process (GO:0009103)3.02779270
72planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02211228
73thyroid hormone metabolic process (GO:0042403)3.01366197
74phenylpropanoid metabolic process (GO:0009698)3.00701451
75extracellular matrix assembly (GO:0085029)2.99812411
76positive regulation of epithelial to mesenchymal transition (GO:0010718)2.93203885
77cell migration involved in heart development (GO:0060973)2.93092941
78regulation of apoptotic cell clearance (GO:2000425)2.92928466
79regulation of chondrocyte differentiation (GO:0032330)2.92441265
80heart valve formation (GO:0003188)2.92089328
81sphingomyelin metabolic process (GO:0006684)2.91540170
82lens fiber cell development (GO:0070307)2.89315562
83negative regulation of protein activation cascade (GO:2000258)2.87758957
84cell proliferation involved in kidney development (GO:0072111)2.85367401
85positive regulation of smoothened signaling pathway (GO:0045880)2.81578238
86fibrinolysis (GO:0042730)2.80919612
87establishment of apical/basal cell polarity (GO:0035089)2.80452688
88retina vasculature morphogenesis in camera-type eye (GO:0061299)2.79481284
89extracellular regulation of signal transduction (GO:1900115)2.78929765
90extracellular negative regulation of signal transduction (GO:1900116)2.78929765
91purine ribonucleotide transport (GO:0015868)2.78260945
92regulation of axon guidance (GO:1902667)2.78204888
93regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77179464
94regulation of cartilage development (GO:0061035)2.76483135
95extracellular matrix disassembly (GO:0022617)2.76240023
96chondroitin sulfate catabolic process (GO:0030207)2.76131364
97cellular response to cholesterol (GO:0071397)2.75612055
98cell adhesion mediated by integrin (GO:0033627)2.75246277
99establishment of tissue polarity (GO:0007164)2.72785998
100establishment of planar polarity (GO:0001736)2.72785998
101negative regulation of complement activation (GO:0045916)2.72488914
102photoreceptor cell differentiation (GO:0046530)2.70436504
103eye photoreceptor cell differentiation (GO:0001754)2.70436504
104adenine nucleotide transport (GO:0051503)2.68251683
105negative regulation of leukocyte chemotaxis (GO:0002689)2.68067846
106regulation of tight junction assembly (GO:2000810)2.67734877
107cochlea morphogenesis (GO:0090103)2.67157140
108aminoglycan biosynthetic process (GO:0006023)2.67093955
109glycosaminoglycan biosynthetic process (GO:0006024)2.67025856
110regulation of plasminogen activation (GO:0010755)2.66569890
111chondrocyte differentiation (GO:0002062)2.65331864
112negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.65037069
113extracellular matrix organization (GO:0030198)2.64153738
114regulation of transforming growth factor beta2 production (GO:0032909)2.63352834
115vascular endothelial growth factor signaling pathway (GO:0038084)2.63107794
116extracellular structure organization (GO:0043062)2.63002901
117regulation of steroid hormone biosynthetic process (GO:0090030)2.62811850
118muscle cell migration (GO:0014812)2.61947386
119cilium or flagellum-dependent cell motility (GO:0001539)2.61834232
120convergent extension (GO:0060026)2.60667444
121protein hydroxylation (GO:0018126)2.60614830
122smooth muscle tissue development (GO:0048745)2.60340670
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.59759571
124ethanol oxidation (GO:0006069)2.59360838
125Golgi transport vesicle coating (GO:0048200)2.59210635
126COPI coating of Golgi vesicle (GO:0048205)2.59210635
127cerebral cortex radially oriented cell migration (GO:0021799)2.58727965
128cell migration involved in sprouting angiogenesis (GO:0002042)2.58510369
129regulation of integrin-mediated signaling pathway (GO:2001044)2.58305886
130positive regulation of mesenchymal cell proliferation (GO:0002053)2.57103549
131heparin biosynthetic process (GO:0030210)2.56925807
132heparin metabolic process (GO:0030202)2.56925807
133regulation of extracellular matrix disassembly (GO:0010715)2.56889449
134epithelial cell-cell adhesion (GO:0090136)2.55785993
135glial cell migration (GO:0008347)2.55754029
136negative regulation of fatty acid transport (GO:2000192)2.55423786
137epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.54307185
138glial cell proliferation (GO:0014009)2.53911238
139cellular response to vitamin D (GO:0071305)2.53784417
140regulation of mesenchymal cell proliferation (GO:0010464)2.53782555
141L-serine transport (GO:0015825)2.53066207
142cell differentiation involved in metanephros development (GO:0072202)2.53056985
143negative regulation of biomineral tissue development (GO:0070168)2.52440853
144T-helper 1 type immune response (GO:0042088)2.51916378
145craniofacial suture morphogenesis (GO:0097094)2.51776173
146epoxygenase P450 pathway (GO:0019373)2.51584007
147omega-hydroxylase P450 pathway (GO:0097267)2.51506320
148keratinocyte proliferation (GO:0043616)2.50818078
149cilium movement (GO:0003341)2.49166880
150regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48410316
151positive regulation of collagen biosynthetic process (GO:0032967)2.48149861
152negative regulation of axon extension involved in axon guidance (GO:0048843)2.48058535
153COPII vesicle coating (GO:0048208)2.47398216
154negative regulation of protein localization to cell surface (GO:2000009)2.47266448
155drug catabolic process (GO:0042737)2.46512795
156regulation of establishment of planar polarity (GO:0090175)2.46368570
157virion attachment to host cell (GO:0019062)2.46349794
158adhesion of symbiont to host cell (GO:0044650)2.46349794
159axon extension involved in axon guidance (GO:0048846)2.46155892
160neuron projection extension involved in neuron projection guidance (GO:1902284)2.46155892
161exogenous drug catabolic process (GO:0042738)2.45211893
162substrate adhesion-dependent cell spreading (GO:0034446)2.43886874
163apoptotic cell clearance (GO:0043277)2.39060165
164lung vasculature development (GO:0060426)2.38035357
165negative regulation of smooth muscle cell migration (GO:0014912)2.37863752
166regulation of non-canonical Wnt signaling pathway (GO:2000050)2.37551946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.38961909
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.17532026
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.41928007
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.28742491
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05382111
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.90946825
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.77495489
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.76492634
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.73644175
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.45327628
11CJUN_26792858_Chip-Seq_BT549_Human2.35409662
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.32093165
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23147423
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20640229
15PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16843844
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15802866
17* ESR2_21235772_ChIP-Seq_MCF-7_Human2.12236795
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.08452487
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.03775156
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00669821
21AR_21572438_ChIP-Seq_LNCaP_Human1.98171973
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97955976
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85735068
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85425371
25TP53_20018659_ChIP-ChIP_R1E_Mouse1.84901009
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.81973697
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81505653
28TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.79801012
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.75029920
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.75029920
31CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.74751898
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74487570
33SOX2_20726797_ChIP-Seq_SW620_Human1.73530649
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.71919248
35AHR_22903824_ChIP-Seq_MCF-7_Human1.71896292
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67995232
37TP53_18474530_ChIP-ChIP_U2OS_Human1.67831026
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67596382
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65587293
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.62581228
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62271503
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62237383
43* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57969714
44* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57969714
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.57257144
46CLOCK_20551151_ChIP-Seq_293T_Human1.56391114
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54826047
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.53812392
49* RXR_22108803_ChIP-Seq_LS180_Human1.53681344
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.52033852
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.49008184
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.48994189
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.48138010
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47797233
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45693231
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45352111
57SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.41885444
58SA1_22415368_ChIP-Seq_MEFs_Mouse1.38641725
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37886262
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35826021
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35788295
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35121693
63SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35121693
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34905942
65BRD4_25478319_ChIP-Seq_HGPS_Human1.34286847
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32529098
67HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.32516757
68SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31025545
69BCAT_22108803_ChIP-Seq_LS180_Human1.31011299
70ZNF274_21170338_ChIP-Seq_K562_Hela1.30974129
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.28508081
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28415550
73EZH2_22144423_ChIP-Seq_EOC_Human1.26077368
74GBX2_23144817_ChIP-Seq_PC3_Human1.25953513
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24992351
76* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23715668
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23694647
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22595482
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20492801
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.19517479
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19174047
82NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17747616
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17184971
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16020449
85* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14008058
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13469696
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11819711
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10165137
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08285319
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08206053
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07660842
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06259716
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06177291
94NFI_21473784_ChIP-Seq_ESCs_Mouse1.06142859
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05188296
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02760127
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01743834
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.01209014
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00740500
100SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00231273
101KLF5_25053715_ChIP-Seq_YYC3_Human0.99622925
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99148148
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98963560
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98433931
105* PIAS1_25552417_ChIP-Seq_VCAP_Human0.98269788
106ISL1_27105846_Chip-Seq_CPCs_Mouse0.97763226
107* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97450649
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.96298280
109TBX20_22080862_ChIP-Seq_HEART_Mouse0.96298280
110NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96276668
111EZH2_27294783_Chip-Seq_ESCs_Mouse0.95992259
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95328422
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.95184824
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.95013867
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94782016
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.93557129
117TP63_23658742_ChIP-Seq_EP156T_Human0.93290197
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.92529186
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92501207
120TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91236233
121NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91152149
122STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90770736
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89578628
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89538804
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.89527968
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89497656
127GATA4_25053715_ChIP-Seq_YYC3_Human0.88496164
128ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88321030
129ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88251754
130TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87617749
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87423485
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.87375580
133STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87312961
134SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86851515
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.82604596
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80961579
137TP53_16413492_ChIP-PET_HCT116_Human0.78675961
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.77302690
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77037459
140IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76834248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.22251998
2MP0005503_abnormal_tendon_morphology4.66580547
3MP0003279_aneurysm4.09553453
4MP0008004_abnormal_stomach_pH3.61509104
5MP0005275_abnormal_skin_tensile3.13788555
6MP0003705_abnormal_hypodermis_morpholog3.12045317
7MP0009250_abnormal_appendicular_skeleto2.85642667
8MP0006054_spinal_hemorrhage2.83451800
9MP0004272_abnormal_basement_membrane2.73340651
10MP0000566_synostosis2.71492425
11MP0004134_abnormal_chest_morphology2.60377192
12MP0009384_cardiac_valve_regurgitation2.55754064
13MP0002282_abnormal_trachea_morphology2.45662509
14MP0005508_abnormal_skeleton_morphology2.43587815
15MP0010030_abnormal_orbit_morphology2.37732250
16MP0001958_emphysema2.21517766
17MP0002933_joint_inflammation2.16744052
18MP0000163_abnormal_cartilage_morphology1.98149870
19MP0008875_abnormal_xenobiotic_pharmacok1.93277393
20MP0002249_abnormal_larynx_morphology1.90791355
21MP0002115_abnormal_skeleton_extremities1.87975131
22MP0010368_abnormal_lymphatic_system1.84299248
23MP0000049_abnormal_middle_ear1.82118642
24MP0003566_abnormal_cell_adhesion1.76439152
25MP0000013_abnormal_adipose_tissue1.69823957
26MP0005390_skeleton_phenotype1.69768411
27MP0001299_abnormal_eye_distance/1.59424774
28MP0005360_urolithiasis1.58040963
29MP0005623_abnormal_meninges_morphology1.57537380
30MP0005365_abnormal_bile_salt1.55869672
31MP0002896_abnormal_bone_mineralization1.53079558
32MP0000534_abnormal_ureter_morphology1.47740909
33MP0005085_abnormal_gallbladder_physiolo1.46367546
34MP0002113_abnormal_skeleton_development1.45569471
35MP0002060_abnormal_skin_morphology1.44652947
36MP0002089_abnormal_postnatal_growth/wei1.43003070
37MP0002109_abnormal_limb_morphology1.41781638
38MP0003942_abnormal_urinary_system1.41197300
39MP0001542_abnormal_bone_strength1.38232834
40MP0002295_abnormal_pulmonary_circulatio1.35021975
41MP0001243_abnormal_dermal_layer1.33771783
42MP0002108_abnormal_muscle_morphology1.32270314
43MP0000751_myopathy1.31342318
44MP0005023_abnormal_wound_healing1.27690519
45MP0005257_abnormal_intraocular_pressure1.27293653
46MP0005171_absent_coat_pigmentation1.25924174
47MP0000767_abnormal_smooth_muscle1.25033811
48MP0003868_abnormal_feces_composition1.24558895
49MP0000762_abnormal_tongue_morphology1.23218648
50MP0001879_abnormal_lymphatic_vessel1.22928966
51MP0003091_abnormal_cell_migration1.22374559
52MP0001533_abnormal_skeleton_physiology1.21980709
53MP0002139_abnormal_hepatobiliary_system1.21963309
54MP0002998_abnormal_bone_remodeling1.21662144
55MP0003646_muscle_fatigue1.20373258
56MP0002932_abnormal_joint_morphology1.17694601
57MP0001346_abnormal_lacrimal_gland1.17200506
58MP0003941_abnormal_skin_development1.16820175
59MP0005408_hypopigmentation1.16776708
60MP0010234_abnormal_vibrissa_follicle1.15530517
61MP0003755_abnormal_palate_morphology1.15197956
62MP0004858_abnormal_nervous_system1.14254655
63MP0003795_abnormal_bone_structure1.13503273
64MP0000343_altered_response_to1.13401857
65MP0002938_white_spotting1.10850327
66MP0003195_calcinosis1.10674262
67MP0001853_heart_inflammation1.07192237
68MP0002116_abnormal_craniofacial_bone1.05956026
69MP0001666_abnormal_nutrient_absorption1.05147665
70MP0003950_abnormal_plasma_membrane1.03549879
71MP0000647_abnormal_sebaceous_gland1.01562420
72MP0001270_distended_abdomen1.01425546
73MP0003045_fibrosis1.01347936
74MP0005595_abnormal_vascular_smooth0.99754755
75MP0009780_abnormal_chondrocyte_physiolo0.98657461
76MP0003252_abnormal_bile_duct0.96095645
77MP0010352_gastrointestinal_tract_polyps0.93582124
78MP0010329_abnormal_lipoprotein_level0.92811397
79MP0005248_abnormal_Harderian_gland0.92548699
80MP0002163_abnormal_gland_morphology0.92288000
81MP0000465_gastrointestinal_hemorrhage0.92211280
82MP0002233_abnormal_nose_morphology0.91489709
83MP0001915_intracranial_hemorrhage0.91071077
84MP0005164_abnormal_response_to0.90674728
85MP0001873_stomach_inflammation0.90378478
86MP0001177_atelectasis0.89434573
87MP0003935_abnormal_craniofacial_develop0.88722714
88MP0001664_abnormal_digestion0.87749828
89MP0002254_reproductive_system_inflammat0.86782056
90MP0000432_abnormal_head_morphology0.86751425
91MP0002234_abnormal_pharynx_morphology0.86662546
92MP0008775_abnormal_heart_ventricle0.86353184
93MP0003937_abnormal_limbs/digits/tail_de0.86135204
94MP0005187_abnormal_penis_morphology0.83984314
95MP0003115_abnormal_respiratory_system0.83351111
96MP0003724_increased_susceptibility_to0.82617877
97MP0002128_abnormal_blood_circulation0.82407955
98MP0000467_abnormal_esophagus_morphology0.82314394
99MP0000428_abnormal_craniofacial_morphol0.81667152
100MP0003186_abnormal_redox_activity0.81370453
101MP0005197_abnormal_uvea_morphology0.79486380
102MP0005165_increased_susceptibility_to0.78915121
103MP0004883_abnormal_blood_vessel0.77946050
104MP0000003_abnormal_adipose_tissue0.77783532
105MP0000462_abnormal_digestive_system0.75964310
106MP0002168_other_aberrant_phenotype0.75640815
107MP0002114_abnormal_axial_skeleton0.74917635
108MP0000733_abnormal_muscle_development0.74345649
109MP0004808_abnormal_hematopoietic_stem0.73955114
110MP0000538_abnormal_urinary_bladder0.72843709
111MP0001849_ear_inflammation0.72740509
112MP0005381_digestive/alimentary_phenotyp0.72462633
113* MP0001614_abnormal_blood_vessel0.71390366
114MP0003385_abnormal_body_wall0.71383927
115MP0005379_endocrine/exocrine_gland_phen0.70968330
116MP0001661_extended_life_span0.70138760
117MP0003283_abnormal_digestive_organ0.70119977
118MP0005670_abnormal_white_adipose0.70089006
119MP0005395_other_phenotype0.68641602
120MP0001663_abnormal_digestive_system0.68573990
121MP0009697_abnormal_copulation0.67816321
122MP0005666_abnormal_adipose_tissue0.66629259
123MP0008789_abnormal_olfactory_epithelium0.64626278
124MP0000427_abnormal_hair_cycle0.64383344
125MP0009053_abnormal_anal_canal0.64356696
126MP0005375_adipose_tissue_phenotype0.64096794
127MP0004782_abnormal_surfactant_physiolog0.63078959
128MP0000639_abnormal_adrenal_gland0.60904376
129MP0002876_abnormal_thyroid_physiology0.59705869
130MP0002697_abnormal_eye_size0.57867819
131MP0002133_abnormal_respiratory_system0.57249592
132MP0005388_respiratory_system_phenotype0.57249592

Predicted human phenotypes

RankGene SetZ-score
1Neonatal short-limb short stature (HP:0008921)6.10203741
2Protrusio acetabuli (HP:0003179)6.00281318
3Vitreoretinal degeneration (HP:0000655)4.71419573
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.69520190
5Premature rupture of membranes (HP:0001788)4.58396856
6Epiphyseal dysplasia (HP:0002656)4.43286294
7* Vascular tortuosity (HP:0004948)4.02562849
8Irregular epiphyses (HP:0010582)3.95351524
9Hypoplastic ischia (HP:0003175)3.92451598
10Cupped ribs (HP:0000887)3.90984097
11Abnormality of dentin (HP:0010299)3.80269613
12Biconcave vertebral bodies (HP:0004586)3.49310321
13Cervical subluxation (HP:0003308)3.47112067
14* Arterial tortuosity (HP:0005116)3.40650225
15Deep venous thrombosis (HP:0002625)3.34417162
16Abnormality of the ischium (HP:0003174)3.33248098
17Flat capital femoral epiphysis (HP:0003370)3.30022207
18* Aortic dissection (HP:0002647)3.24786275
19Complement deficiency (HP:0004431)3.09040775
20Short 4th metacarpal (HP:0010044)3.03612483
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.03612483
22Ectopia lentis (HP:0001083)3.02711594
23Flat acetabular roof (HP:0003180)3.00213063
24Osteoarthritis (HP:0002758)2.99076390
25Ankle contracture (HP:0006466)2.92961536
26Peritonitis (HP:0002586)2.90763809
27Infantile muscular hypotonia (HP:0008947)2.90632624
28Aortic aneurysm (HP:0004942)2.85327218
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.82686275
30Abnormality of the pubic bones (HP:0003172)2.80544130
31Follicular hyperkeratosis (HP:0007502)2.73691828
32Broad metatarsal (HP:0001783)2.73147529
33Cardiovascular calcification (HP:0011915)2.72324943
34Vertebral compression fractures (HP:0002953)2.67825024
35Atrophic scars (HP:0001075)2.67078787
36Aplasia involving bones of the extremities (HP:0009825)2.66383898
37Aplasia involving bones of the upper limbs (HP:0009823)2.66383898
38Aplasia of the phalanges of the hand (HP:0009802)2.66383898
39Radial bowing (HP:0002986)2.65019871
40Calcaneovalgus deformity (HP:0001848)2.64250240
41Abnormality of complement system (HP:0005339)2.62940959
42* Soft skin (HP:0000977)2.62769480
43Bowel diverticulosis (HP:0005222)2.62642789
44Mitral stenosis (HP:0001718)2.61526088
45Genu recurvatum (HP:0002816)2.59707905
46Coxa vara (HP:0002812)2.58694995
47Abnormal tarsal ossification (HP:0008369)2.58240215
48Rhinitis (HP:0012384)2.57968781
49Slender build (HP:0001533)2.52445004
50Shallow orbits (HP:0000586)2.51821584
51Abnormality of the calcaneus (HP:0008364)2.50052397
52Abnormal respiratory motile cilium morphology (HP:0005938)2.47915530
53Abnormal respiratory epithelium morphology (HP:0012253)2.47915530
54Wormian bones (HP:0002645)2.44379429
55Abnormal delivery (HP:0001787)2.43323289
56Abnormality of the acetabulum (HP:0003170)2.42644768
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42511247
58Abnormal vertebral ossification (HP:0100569)2.42346689
59Deformed tarsal bones (HP:0008119)2.41439321
60Fragile skin (HP:0001030)2.40886068
61Beaking of vertebral bodies (HP:0004568)2.40485782
62Abnormal respiratory motile cilium physiology (HP:0012261)2.39272923
63Abnormality of the phalanges of the 2nd finger (HP:0009541)2.38709312
64Platyspondyly (HP:0000926)2.38141980
65* Joint laxity (HP:0001388)2.37331683
66Decreased skull ossification (HP:0004331)2.34434071
67Hypoplastic pelvis (HP:0008839)2.34197404
68Abnormal ciliary motility (HP:0012262)2.33724145
69Small epiphyses (HP:0010585)2.33581576
70Coronal craniosynostosis (HP:0004440)2.33441103
71Absent frontal sinuses (HP:0002688)2.32778104
72Type 1 muscle fiber predominance (HP:0003803)2.32286653
73Absent/shortened dynein arms (HP:0200106)2.28739313
74Dynein arm defect of respiratory motile cilia (HP:0012255)2.28739313
75Short nail (HP:0001799)2.24010977
76Cerebral aneurysm (HP:0004944)2.20225124
77Bowing of the arm (HP:0006488)2.19734596
78Bowed forearm bones (HP:0003956)2.19734596
79Elbow flexion contracture (HP:0002987)2.18034394
80Thin ribs (HP:0000883)2.17408351
81Broad ribs (HP:0000885)2.16687383
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.16045717
83Blue sclerae (HP:0000592)2.15096636
84Abnormality of incisor morphology (HP:0011063)2.14353072
85Wide anterior fontanel (HP:0000260)2.13288196
86* Hyperextensible skin (HP:0000974)2.11829357
87Genu varum (HP:0002970)2.11058011
88Patent foramen ovale (HP:0001655)2.10966114
89Abnormality of the proximal phalanges of the hand (HP:0009834)2.09577617
90Mild short stature (HP:0003502)2.09222246
91Abnormality of the 4th metacarpal (HP:0010012)2.08464638
92Spinal rigidity (HP:0003306)2.07820055
93Femoral bowing (HP:0002980)2.06983163
94Round face (HP:0000311)2.06950790
95* Dilatation of the ascending aorta (HP:0005111)2.06677850
96Abnormality of skull ossification (HP:0002703)2.06465514
97Ovoid vertebral bodies (HP:0003300)2.06099414
98Vascular calcification (HP:0004934)2.05779610
99Spondylolisthesis (HP:0003302)2.04688084
100Bladder diverticulum (HP:0000015)2.03321439
101Camptodactyly of toe (HP:0001836)2.03166356
102Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03097850
103Vertebral hypoplasia (HP:0008417)2.03097850
104Long toe (HP:0010511)2.02725369
105Mitral valve prolapse (HP:0001634)2.02531055
106Ulnar bowing (HP:0003031)2.01958776
107Intrahepatic cholestasis (HP:0001406)2.01195168
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.01001974
109Broad face (HP:0000283)2.00543158
110Bell-shaped thorax (HP:0001591)1.99622450
111Abnormality of the parietal bone (HP:0002696)1.98925419
112Exostoses (HP:0100777)1.97747719
113Nonimmune hydrops fetalis (HP:0001790)1.95614612
114Morphological abnormality of the middle ear (HP:0008609)1.95279889
115Protuberant abdomen (HP:0001538)1.95198409
116Abnormal ossification of hand bones (HP:0005921)1.94261762
117Abnormal foot bone ossification (HP:0010675)1.93908283
118Humeroradial synostosis (HP:0003041)1.93743025
119Synostosis involving the elbow (HP:0003938)1.93743025
120Hypoplastic ilia (HP:0000946)1.93674328
121Joint stiffness (HP:0001387)1.93207847
122Mitral regurgitation (HP:0001653)1.92696018
123Abnormality of femoral epiphyses (HP:0006499)1.92317337
124Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.92317337
125Conjugated hyperbilirubinemia (HP:0002908)1.92205413
126Aplasia/Hypoplasia of the fibula (HP:0006492)1.91374698
127Fibular hypoplasia (HP:0003038)1.91312607
128Mildly elevated creatine phosphokinase (HP:0008180)1.89436248
129Abnormality of carpal bone ossification (HP:0006257)1.89271191
130Aplasia/Hypoplasia of the scapulae (HP:0006713)1.88658873
131Hypoplastic scapulae (HP:0000882)1.88658873
132Overgrowth (HP:0001548)1.88594646
133Hypoplasia of the iris (HP:0007676)1.88582899
134Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88551023
135Renal duplication (HP:0000075)1.87805749
136Flattened epiphyses (HP:0003071)1.87788441
137Prolonged partial thromboplastin time (HP:0003645)1.87530651
138Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.86609815
139Hypoventilation (HP:0002791)1.86281485
140* Aortic regurgitation (HP:0001659)1.85920173
141Abnormality of proline metabolism (HP:0010907)1.82787166
142Hydroxyprolinuria (HP:0003080)1.82787166
143* Aneurysm (HP:0002617)1.81692107
144Protruding ear (HP:0000411)1.74822527
145* Inguinal hernia (HP:0000023)1.73647084
146Natal tooth (HP:0000695)1.70787587
147Wrist flexion contracture (HP:0001239)1.70181656
148Broad long bones (HP:0005622)1.68633439
149Chronic bronchitis (HP:0004469)1.68146064
150Renovascular hypertension (HP:0100817)1.68107500
151Atelectasis (HP:0100750)1.67962368
152Breech presentation (HP:0001623)1.67268125
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66411744
154Deviation of the hallux (HP:0010051)1.66111714
155Abnormal hand bone ossification (HP:0010660)1.65954771
156Xanthomatosis (HP:0000991)1.65514647
157Thin bony cortex (HP:0002753)1.65295971
158Increased variability in muscle fiber diameter (HP:0003557)1.65193678
159* Aortic valve stenosis (HP:0001650)1.63062086
160Asymmetry of the thorax (HP:0001555)1.61685028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.15223341
2TRIB33.19573993
3EPHA22.99194067
4LATS12.95583829
5MUSK2.89207871
6LMTK22.85921709
7MAPK152.74013203
8SIK12.72580773
9IRAK32.69621837
10PIK3CA2.67833662
11PRKD32.46851102
12NTRK12.35218428
13EPHB22.30096174
14MYLK2.23728082
15ERN12.11229872
16IRAK12.10179341
17EPHA32.04014012
18TIE12.01787670
19FGFR41.97048152
20TRPM71.84785374
21RIPK11.84028528
22NEK91.83326747
23MAP3K31.82947424
24NLK1.82459712
25AKT31.79592730
26STK38L1.75547817
27FRK1.70260111
28PHKG21.64003319
29PHKG11.64003319
30ERBB41.62708187
31PRKG21.61451033
32PDGFRA1.56964106
33LATS21.49488212
34TTN1.49165018
35TGFBR21.48328017
36PTK21.38990268
37KIT1.37329184
38TAOK21.34257815
39STK381.34071096
40GRK11.31274613
41PIK3CG1.25214066
42PAK41.21570005
43PIM21.14898554
44ERBB31.13574082
45BCKDK1.13110691
46IRAK21.12567407
47ROCK11.10932145
48ROCK21.07562537
49PAK21.06072628
50WNK41.04819859
51MET1.01357981
52JAK30.98717790
53BMX0.95923516
54PKN20.92353707
55ICK0.89947236
56GRK50.89686650
57FER0.87986515
58MTOR0.83191905
59STK240.82674111
60RPS6KA20.81769489
61PRKD20.81599950
62MAPKAPK30.81318417
63CAMKK20.77716404
64STK390.77183337
65LRRK20.76889161
66STK30.76808776
67FGFR10.76337939
68MAPK130.76277513
69KDR0.74636369
70ABL20.74514399
71PRKCE0.72678106
72RPS6KA40.72495783
73GSK3A0.72239747
74CDK80.68990311
75CASK0.68799386
76FGFR20.67710346
77ERBB20.66683344
78MAP4K20.65484423
79PTK2B0.65298151
80ADRBK20.64799452
81ILK0.63429990
82TNIK0.63102482
83MAPK70.62472272
84MAPKAPK50.62407543
85FGFR30.61883914
86LIMK10.61651001
87SGK20.61502257
88FLT30.61006492
89PBK0.60945783
90PDGFRB0.60117552
91BCR0.58925930
92MATK0.58435812
93PDK20.54843796
94PRKD10.53507152
95EEF2K0.53158961
96WNK10.53125500
97PAK30.52914223
98CSF1R0.52384837
99CAMK2D0.50638126
100PRPF4B0.50301266
101EPHB10.49833895
102MST1R0.49112071
103MAP3K70.48542312
104MAPK120.47367174
105CAMK2G0.46303675
106IGF1R0.46277913
107SGK2230.46037486
108SGK4940.46037486
109MAP3K120.45468797
110PTK60.45064714
111MAP3K140.44042799
112RET0.43701963
113MELK0.43562992
114SIK30.43462606
115TYRO30.42338121
116MAP2K10.41949907
117TGFBR10.41587621
118MAP2K30.41198802
119MAPKAPK20.40263901
120ABL10.39929510
121CDC42BPA0.37453589
122PRKCH0.37451932
123MAP3K60.36942611
124TESK10.36032981
125MOS0.35729880
126BRSK20.35546658
127MST40.33456806
128CHUK0.33112579
129PNCK0.33046258
130SRC0.32383396
131ADRBK10.31716456
132JAK10.30940286
133TEC0.30750207
134ZAK0.30343336
135GRK70.30243770
136DMPK0.29748241
137SGK30.29586892
138PRKCI0.29585349
139PRKAA20.28172356
140MAPK30.26903700

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.38050900
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.24665389
3Complement and coagulation cascades_Homo sapiens_hsa046103.30372777
4Protein digestion and absorption_Homo sapiens_hsa049743.24138834
5Basal cell carcinoma_Homo sapiens_hsa052172.84471242
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.72806020
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.54429924
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.43946785
9Malaria_Homo sapiens_hsa051442.39703450
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.37968173
11Focal adhesion_Homo sapiens_hsa045102.34713333
12Fatty acid biosynthesis_Homo sapiens_hsa000612.29566955
13Sulfur metabolism_Homo sapiens_hsa009202.21504708
14Histidine metabolism_Homo sapiens_hsa003402.20921623
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10520998
16Retinol metabolism_Homo sapiens_hsa008302.03047455
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00908576
18Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.99019471
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.92531786
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90750707
21Caffeine metabolism_Homo sapiens_hsa002321.90728023
22Tyrosine metabolism_Homo sapiens_hsa003501.89818164
23Phenylalanine metabolism_Homo sapiens_hsa003601.80045180
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79502023
25Proteoglycans in cancer_Homo sapiens_hsa052051.79252849
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79063481
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78318500
28Hippo signaling pathway_Homo sapiens_hsa043901.68056657
29TGF-beta signaling pathway_Homo sapiens_hsa043501.61365851
30Hedgehog signaling pathway_Homo sapiens_hsa043401.54108600
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47584451
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46821763
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37614681
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36708785
35Dilated cardiomyopathy_Homo sapiens_hsa054141.35917961
36N-Glycan biosynthesis_Homo sapiens_hsa005101.35452993
37Sphingolipid metabolism_Homo sapiens_hsa006001.33093336
38Ovarian steroidogenesis_Homo sapiens_hsa049131.33012146
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31170230
40Fatty acid metabolism_Homo sapiens_hsa012121.29230394
41beta-Alanine metabolism_Homo sapiens_hsa004101.28819940
42ABC transporters_Homo sapiens_hsa020101.27552524
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27264151
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23900341
45Amoebiasis_Homo sapiens_hsa051461.18539864
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18513159
47Arginine biosynthesis_Homo sapiens_hsa002201.14140016
48Other glycan degradation_Homo sapiens_hsa005111.13656938
49Small cell lung cancer_Homo sapiens_hsa052221.10767805
50Adherens junction_Homo sapiens_hsa045201.08841053
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07387778
52Leishmaniasis_Homo sapiens_hsa051401.06907916
53Peroxisome_Homo sapiens_hsa041461.06470269
54Bile secretion_Homo sapiens_hsa049761.05726622
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05644863
56Bladder cancer_Homo sapiens_hsa052191.04142521
57Vitamin B6 metabolism_Homo sapiens_hsa007501.03773152
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03343265
59Toxoplasmosis_Homo sapiens_hsa051451.03060483
60Melanogenesis_Homo sapiens_hsa049161.02039840
61Glutathione metabolism_Homo sapiens_hsa004801.01820547
62MicroRNAs in cancer_Homo sapiens_hsa052061.00391202
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93180016
64Shigellosis_Homo sapiens_hsa051310.93061124
65Fatty acid degradation_Homo sapiens_hsa000710.92457375
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88669781
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87762326
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86618412
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.86162604
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86097101
71Pathways in cancer_Homo sapiens_hsa052000.85218709
72Platelet activation_Homo sapiens_hsa046110.85144961
73Tryptophan metabolism_Homo sapiens_hsa003800.85049004
74Linoleic acid metabolism_Homo sapiens_hsa005910.82207411
75Wnt signaling pathway_Homo sapiens_hsa043100.82092565
76Salmonella infection_Homo sapiens_hsa051320.80568236
77Arginine and proline metabolism_Homo sapiens_hsa003300.80129273
78Prion diseases_Homo sapiens_hsa050200.79432416
79Butanoate metabolism_Homo sapiens_hsa006500.78548852
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77878906
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.75981645
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.75755850
83Fat digestion and absorption_Homo sapiens_hsa049750.75572899
84Vitamin digestion and absorption_Homo sapiens_hsa049770.75516800
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73678632
86TNF signaling pathway_Homo sapiens_hsa046680.73300905
87Hematopoietic cell lineage_Homo sapiens_hsa046400.72853143
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71880954
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70640070
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68336855
91Gastric acid secretion_Homo sapiens_hsa049710.68157849
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67615693
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65362944
94Chronic myeloid leukemia_Homo sapiens_hsa052200.64887332
95Rap1 signaling pathway_Homo sapiens_hsa040150.64681898
96Sulfur relay system_Homo sapiens_hsa041220.64528569
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64411332
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63546983
99Selenocompound metabolism_Homo sapiens_hsa004500.62674487
100Fructose and mannose metabolism_Homo sapiens_hsa000510.62540939
101Melanoma_Homo sapiens_hsa052180.62169790
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59938694
103PPAR signaling pathway_Homo sapiens_hsa033200.59651529
104Steroid biosynthesis_Homo sapiens_hsa001000.57769925
105Thyroid hormone synthesis_Homo sapiens_hsa049180.56897733
106Renin-angiotensin system_Homo sapiens_hsa046140.55816758
107Pyruvate metabolism_Homo sapiens_hsa006200.55787645
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55535229
109Mineral absorption_Homo sapiens_hsa049780.55001981
110Legionellosis_Homo sapiens_hsa051340.54847107
111Pertussis_Homo sapiens_hsa051330.54541268
112Arachidonic acid metabolism_Homo sapiens_hsa005900.53897193
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52987652
114Starch and sucrose metabolism_Homo sapiens_hsa005000.51197022
115Lysine degradation_Homo sapiens_hsa003100.51035352
116HTLV-I infection_Homo sapiens_hsa051660.51024054
117Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50727317
118Folate biosynthesis_Homo sapiens_hsa007900.50455942
119Prostate cancer_Homo sapiens_hsa052150.48186518
120p53 signaling pathway_Homo sapiens_hsa041150.48046943
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.46746659
122Tight junction_Homo sapiens_hsa045300.45907244
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45639340
124Biosynthesis of amino acids_Homo sapiens_hsa012300.42962223
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42327683
126Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42316401
127Propanoate metabolism_Homo sapiens_hsa006400.41730361
128Glycerolipid metabolism_Homo sapiens_hsa005610.41684750
129Insulin resistance_Homo sapiens_hsa049310.41421753
130Viral myocarditis_Homo sapiens_hsa054160.40453419
131Axon guidance_Homo sapiens_hsa043600.38865960
132Pancreatic secretion_Homo sapiens_hsa049720.38790870
133Notch signaling pathway_Homo sapiens_hsa043300.38768008
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38250997
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.37157424
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36629188
137Fatty acid elongation_Homo sapiens_hsa000620.36604598
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36222428
139AMPK signaling pathway_Homo sapiens_hsa041520.35998411
140Chemical carcinogenesis_Homo sapiens_hsa052040.34634739
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33606992
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32441653
143Nitrogen metabolism_Homo sapiens_hsa009100.32306793
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.32223861
145Rheumatoid arthritis_Homo sapiens_hsa053230.31854359
146Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28227677
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27930080

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