SLC2A12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.28953561
2presynaptic membrane assembly (GO:0097105)4.06559178
3negative regulation of axon extension involved in axon guidance (GO:0048843)3.97311010
4vitamin A metabolic process (GO:0006776)3.91988020
5neuron cell-cell adhesion (GO:0007158)3.89112547
6limb bud formation (GO:0060174)3.86151680
7hemidesmosome assembly (GO:0031581)3.85041698
8sympathetic nervous system development (GO:0048485)3.73310057
9diterpenoid biosynthetic process (GO:0016102)3.70167580
10retinal metabolic process (GO:0042574)3.68123280
11negative regulation of axon guidance (GO:1902668)3.57915962
12desmosome organization (GO:0002934)3.52654878
13mesonephros development (GO:0001823)3.40757324
14paraxial mesoderm development (GO:0048339)3.40021830
15short-term memory (GO:0007614)3.39262419
16presynaptic membrane organization (GO:0097090)3.37923709
17positive regulation of gastrulation (GO:2000543)3.36778150
18negative regulation of chondrocyte differentiation (GO:0032331)3.26088288
19forebrain neuron development (GO:0021884)3.24250617
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.22688475
21regulation of ruffle assembly (GO:1900027)3.20789618
22lateral sprouting from an epithelium (GO:0060601)3.18782098
23viral transcription (GO:0019083)3.16917645
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.13007562
25terpenoid biosynthetic process (GO:0016114)3.12661878
26righting reflex (GO:0060013)3.09771884
27regulation of axon extension involved in axon guidance (GO:0048841)3.09514918
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09185408
29glomerulus development (GO:0032835)3.06573595
30establishment of tissue polarity (GO:0007164)3.03646359
31establishment of planar polarity (GO:0001736)3.03646359
32keratinocyte development (GO:0003334)3.02608842
33glomerular basement membrane development (GO:0032836)3.02447968
34regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.99254010
35regulation of axon guidance (GO:1902667)2.94352957
36translational termination (GO:0006415)2.93952532
37negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.92113704
38ATP synthesis coupled proton transport (GO:0015986)2.88988312
39energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88988312
40kidney mesenchyme development (GO:0072074)2.83833179
41vocalization behavior (GO:0071625)2.82324075
42positive regulation of synapse assembly (GO:0051965)2.82285760
43positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.79417654
44positive regulation of osteoblast proliferation (GO:0033690)2.79091638
45membrane assembly (GO:0071709)2.77615505
46cardiac myofibril assembly (GO:0055003)2.76908736
47axon extension involved in axon guidance (GO:0048846)2.76724820
48neuron projection extension involved in neuron projection guidance (GO:1902284)2.76724820
49sphingoid metabolic process (GO:0046519)2.73748503
50regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72029556
51negative chemotaxis (GO:0050919)2.70447086
52neuron recognition (GO:0008038)2.69680039
53ovulation cycle (GO:0042698)2.67273915
54type B pancreatic cell proliferation (GO:0044342)2.67062179
55glomerular visceral epithelial cell development (GO:0072015)2.66839938
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66235388
57regulation of cardioblast differentiation (GO:0051890)2.65620009
58retina layer formation (GO:0010842)2.64825527
59keratinocyte proliferation (GO:0043616)2.64395627
60regulation of lipoprotein metabolic process (GO:0050746)2.64206674
61calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63363160
62sarcomere organization (GO:0045214)2.63255862
63pattern specification involved in kidney development (GO:0061004)2.63116481
64negative regulation of axon extension (GO:0030517)2.62691043
65regulation of cell proliferation involved in kidney development (GO:1901722)2.61841015
66central nervous system neuron development (GO:0021954)2.59402690
67gap junction assembly (GO:0016264)2.59312689
68negative regulation of osteoblast proliferation (GO:0033689)2.59222243
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58235612
70regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.57850322
71neuronal action potential propagation (GO:0019227)2.56563815
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.54932339
73regulation of mesenchymal cell apoptotic process (GO:2001053)2.54395646
74spinal cord association neuron differentiation (GO:0021527)2.53448936
75actomyosin structure organization (GO:0031032)2.51712063
76positive regulation of meiosis (GO:0045836)2.51424622
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.51014104
78glomerular epithelial cell development (GO:0072310)2.50767170
79response to nitrosative stress (GO:0051409)2.50369371
80positive regulation of cardiac muscle cell differentiation (GO:2000727)2.49691689
81regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.48834084
82mesenchyme morphogenesis (GO:0072132)2.48822597
83apoptotic cell clearance (GO:0043277)2.48811555
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47838331
85negative regulation of Ras GTPase activity (GO:0034261)2.47455468
86ribosomal small subunit biogenesis (GO:0042274)2.47056907
87prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.45214276
88positive regulation of response to oxidative stress (GO:1902884)2.44797688
89positive regulation of cellular response to oxidative stress (GO:1900409)2.44797688
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44467917
91regulation of osteoblast proliferation (GO:0033688)2.43880956
92cotranslational protein targeting to membrane (GO:0006613)2.43827680
93respiratory electron transport chain (GO:0022904)2.43410017
94branching involved in prostate gland morphogenesis (GO:0060442)2.43282207
95cardiac right ventricle morphogenesis (GO:0003215)2.42567142
96fibroblast migration (GO:0010761)2.42248406
97axonal fasciculation (GO:0007413)2.41955686
98myofibril assembly (GO:0030239)2.41791130
99positive regulation of meiotic cell cycle (GO:0051446)2.41646354
100regulation of synapse assembly (GO:0051963)2.41339496
101protein localization to synapse (GO:0035418)2.40523438
102electron transport chain (GO:0022900)2.39636191
103regulation of cell communication by electrical coupling (GO:0010649)2.39147149
104negative regulation of cartilage development (GO:0061037)2.37452214
105protein targeting to ER (GO:0045047)2.37265167
106regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37254944
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.37032535
108cartilage morphogenesis (GO:0060536)2.36775097
109chondrocyte proliferation (GO:0035988)2.36661790
110actin-myosin filament sliding (GO:0033275)2.36396377
111muscle filament sliding (GO:0030049)2.36396377
112synaptic vesicle exocytosis (GO:0016079)2.35167948
113cell migration involved in sprouting angiogenesis (GO:0002042)2.34789432
114cell migration in hindbrain (GO:0021535)2.34356371
115cranial nerve morphogenesis (GO:0021602)2.33964287
116regulation of vesicle fusion (GO:0031338)2.33047506
117regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31548384
118regulation of mesonephros development (GO:0061217)2.31312752
119female gonad development (GO:0008585)2.30550998
120actin-mediated cell contraction (GO:0070252)2.30100832
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29887807
122notochord development (GO:0030903)2.29719927
123chaperone-mediated protein transport (GO:0072321)2.29702671
124cellular protein complex disassembly (GO:0043624)2.29639347
125establishment of protein localization to endoplasmic reticulum (GO:0072599)2.28842887
126camera-type eye morphogenesis (GO:0048593)2.28770668
127glucosamine-containing compound catabolic process (GO:1901072)2.27165741
128dorsal/ventral neural tube patterning (GO:0021904)2.26668456
129axonemal dynein complex assembly (GO:0070286)2.26606060
130Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26191240
131zinc ion transmembrane transport (GO:0071577)2.25032073
132positive regulation of smoothened signaling pathway (GO:0045880)2.24202552
133asymmetric protein localization (GO:0008105)2.24014815
134viral life cycle (GO:0019058)2.23733055
135endocardial cushion morphogenesis (GO:0003203)2.23710383
136keratan sulfate catabolic process (GO:0042340)2.23355233
137retinal ganglion cell axon guidance (GO:0031290)2.23291665
138convergent extension (GO:0060026)2.22495823
139neurotransmitter-gated ion channel clustering (GO:0072578)2.21656202
140regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.21108239
141regulation of establishment of planar polarity (GO:0090175)2.21052173
142regulation of membrane repolarization (GO:0060306)2.21001356
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.20753417
144auditory behavior (GO:0031223)2.20715057
145regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.20682713
146innervation (GO:0060384)2.20232277
147sequestering of extracellular ligand from receptor (GO:0035581)2.19662010
148regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.19430687
149endodermal cell differentiation (GO:0035987)2.19321329
150regulation of apoptotic cell clearance (GO:2000425)2.19197419
151extracellular matrix assembly (GO:0085029)2.18676672
152negative regulation of protein localization to cell surface (GO:2000009)2.18539291
153dopamine biosynthetic process (GO:0042416)2.18535509
154cell differentiation involved in kidney development (GO:0061005)2.18498581
155establishment of apical/basal cell polarity (GO:0035089)2.17731570
156cardiac muscle cell development (GO:0055013)2.17702318
157positive regulation of biomineral tissue development (GO:0070169)2.17546923
158regulation of respiratory system process (GO:0044065)2.17347475
159protein hydroxylation (GO:0018126)2.17271088
160mechanosensory behavior (GO:0007638)2.17219344
161intraciliary transport (GO:0042073)2.16561090
162positive regulation of bone mineralization (GO:0030501)2.16449991
163biotin metabolic process (GO:0006768)2.16446925
164membrane repolarization during action potential (GO:0086011)2.16425598
1654-hydroxyproline metabolic process (GO:0019471)2.16113923
166peptidyl-proline hydroxylation (GO:0019511)2.16089986
167smooth muscle tissue development (GO:0048745)2.14218114
168regulation of protein localization to cell surface (GO:2000008)2.12435917
169regulation of transforming growth factor beta2 production (GO:0032909)2.12208077
170adult heart development (GO:0007512)2.11805526
171cilium movement (GO:0003341)2.11502339
172regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.11203018
173relaxation of cardiac muscle (GO:0055119)2.10434885
174embryonic foregut morphogenesis (GO:0048617)2.09857714
175epithelial cell-cell adhesion (GO:0090136)2.09795326
176organ induction (GO:0001759)2.09539943
177mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.08894567
178muscle cell migration (GO:0014812)2.08885906
179regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.08823188
180dorsal/ventral axis specification (GO:0009950)2.08795005
181cell communication by electrical coupling (GO:0010644)2.08251792
182collagen fibril organization (GO:0030199)2.08051968
183cardiac cell development (GO:0055006)2.07670976
184cytoskeletal anchoring at plasma membrane (GO:0007016)2.07355068
185branched-chain amino acid catabolic process (GO:0009083)2.07119823
186protein localization to cell surface (GO:0034394)2.06848083
187retinol metabolic process (GO:0042572)2.04505702
188amino-acid betaine metabolic process (GO:0006577)2.04400336
189regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.04384699
190polarized epithelial cell differentiation (GO:0030859)2.04100295
191inositol metabolic process (GO:0006020)2.04028968

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39828152
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05113355
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.04890192
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.96149901
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.93549840
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.90003740
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83176594
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83143540
9GBX2_23144817_ChIP-Seq_PC3_Human2.79059556
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75505243
11AR_21572438_ChIP-Seq_LNCaP_Human2.71390297
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.67317116
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60587775
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60587775
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58750178
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.57632994
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54408303
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.38401454
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30571407
20VDR_22108803_ChIP-Seq_LS180_Human2.27641559
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.24329806
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.10177069
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08004003
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04554296
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04347296
26AR_21909140_ChIP-Seq_LNCAP_Human2.03075902
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99570607
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97593811
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92926513
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84507670
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83465344
32TAF15_26573619_Chip-Seq_HEK293_Human1.81777176
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81221780
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.79979141
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.79979141
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79741516
37RNF2_27304074_Chip-Seq_NSC_Mouse1.79328178
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79107615
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78905304
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74305162
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70184512
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.68468759
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66716994
44CLOCK_20551151_ChIP-Seq_293T_Human1.62132913
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61763104
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58718944
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.58555458
48P300_19829295_ChIP-Seq_ESCs_Human1.52926598
49CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.50073057
50* CJUN_26792858_Chip-Seq_BT549_Human1.49992568
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46157676
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.45093888
53ISL1_27105846_Chip-Seq_CPCs_Mouse1.44684651
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42518002
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.42409997
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41564890
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40391547
58* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36899239
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36501358
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35330048
61* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35096505
62YAP1_20516196_ChIP-Seq_MESCs_Mouse1.34868801
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34390461
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33333044
65TP53_16413492_ChIP-PET_HCT116_Human1.32072860
66FUS_26573619_Chip-Seq_HEK293_Human1.30899109
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.30842500
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30461725
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30190735
70* SMAD4_21799915_ChIP-Seq_A2780_Human1.30071591
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29437810
72* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29156706
73* RING1B_27294783_Chip-Seq_NPCs_Mouse1.27740330
74* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26705973
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26702759
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25632130
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23934564
78TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23853182
79* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21680681
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21462736
81TBX20_22328084_ChIP-Seq_HEART_Mouse1.20897706
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.20897706
83* TP53_18474530_ChIP-ChIP_U2OS_Human1.19436519
84BCAT_22108803_ChIP-Seq_LS180_Human1.19260613
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17245132
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.17176200
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.16845967
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16465729
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16388664
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.16233871
91AR_25329375_ChIP-Seq_VCAP_Human1.16036640
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15808418
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15757145
94PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15658484
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15461485
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15381821
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15244254
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15177236
99* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.14893587
100AHR_22903824_ChIP-Seq_MCF-7_Human1.14587892
101IGF1R_20145208_ChIP-Seq_DFB_Human1.14157873
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14046873
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.13959819
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12949573
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12404054
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11660244
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11098506
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10759668
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09027013
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08194806
111SOX2_20726797_ChIP-Seq_SW620_Human1.08090235
112LXR_22158963_ChIP-Seq_LIVER_Mouse1.08033640
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08007920
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.07728668
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07324138
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.06782216
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.06717337
118BRD4_25478319_ChIP-Seq_HGPS_Human1.06541909
119SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04635011
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04539118
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.04370976
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03486364
123* RUNX2_22187159_ChIP-Seq_PCA_Human1.02826903
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02723305
125GATA4_21415370_ChIP-Seq_HL-1_Mouse1.02376547
126ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02257911
127ZNF274_21170338_ChIP-Seq_K562_Hela1.01810981
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01763175
129* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01419127
130SOX9_26525672_Chip-Seq_HEART_Mouse1.01015728
131NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00768742
132STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00555256
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.00449425
134STAT3_23295773_ChIP-Seq_U87_Human0.98685340
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98666266
136EOMES_21245162_ChIP-Seq_HESCs_Human0.98537139
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98216777
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.97487050
139FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96721962
140TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96598902
141CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96285878
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.95926684
143* FOXO3_23340844_ChIP-Seq_DLD1_Human0.95849818
144RXR_22108803_ChIP-Seq_LS180_Human0.95780224
145SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95714813
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95170499
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94407057
148* FOXA1_25552417_ChIP-Seq_VCAP_Human0.94241125
149REST_21632747_ChIP-Seq_MESCs_Mouse0.93886505
150DROSHA_22980978_ChIP-Seq_HELA_Human0.92036623
151EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91091821
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90303808
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.89926387
154ER_23166858_ChIP-Seq_MCF-7_Human0.88292925
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.87889576
156CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87193759
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85505447
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85505447
159NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84765361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.49859551
2MP0000566_synostosis3.41052815
3MP0005248_abnormal_Harderian_gland3.19012354
4MP0005257_abnormal_intraocular_pressure2.80162581
5MP0008438_abnormal_cutaneous_collagen2.64632902
6MP0002009_preneoplasia2.46025569
7MP0009379_abnormal_foot_pigmentation2.38159650
8MP0002254_reproductive_system_inflammat2.38079837
9MP0001346_abnormal_lacrimal_gland2.36520212
10MP0006276_abnormal_autonomic_nervous2.26171981
11MP0003136_yellow_coat_color2.19888616
12MP0005623_abnormal_meninges_morphology2.09955530
13MP0002638_abnormal_pupillary_reflex2.01415925
14MP0009250_abnormal_appendicular_skeleto2.00510722
15MP0001299_abnormal_eye_distance/2.00177698
16MP0003941_abnormal_skin_development1.95701145
17MP0005409_darkened_coat_color1.94053876
18MP0004381_abnormal_hair_follicle1.85197525
19MP0005503_abnormal_tendon_morphology1.81970317
20MP0009780_abnormal_chondrocyte_physiolo1.81246910
21MP0001188_hyperpigmentation1.78895421
22MP0004084_abnormal_cardiac_muscle1.69864861
23MP0000049_abnormal_middle_ear1.69664106
24MP0003385_abnormal_body_wall1.69067786
25MP0010234_abnormal_vibrissa_follicle1.66093075
26MP0000762_abnormal_tongue_morphology1.63713462
27MP0000778_abnormal_nervous_system1.58585842
28MP0000751_myopathy1.56871005
29MP0010386_abnormal_urinary_bladder1.54004131
30MP0002837_dystrophic_cardiac_calcinosis1.51771533
31MP0005187_abnormal_penis_morphology1.51745107
32MP0004036_abnormal_muscle_relaxation1.51057591
33MP0002796_impaired_skin_barrier1.49886349
34MP0002249_abnormal_larynx_morphology1.46641753
35MP0000383_abnormal_hair_follicle1.46096717
36MP0001485_abnormal_pinna_reflex1.45315629
37MP0004233_abnormal_muscle_weight1.43677130
38MP0000749_muscle_degeneration1.43454911
39MP0010352_gastrointestinal_tract_polyps1.43160050
40MP0000462_abnormal_digestive_system1.42958992
41MP0003938_abnormal_ear_development1.41869356
42MP0003122_maternal_imprinting1.40158666
43MP0010030_abnormal_orbit_morphology1.40139734
44MP0003315_abnormal_perineum_morphology1.39712878
45MP0001958_emphysema1.38318046
46MP0010368_abnormal_lymphatic_system1.38276363
47MP0003937_abnormal_limbs/digits/tail_de1.37952755
48MP0002572_abnormal_emotion/affect_behav1.34168102
49MP0002734_abnormal_mechanical_nocicepti1.34152350
50MP0005197_abnormal_uvea_morphology1.34126558
51MP0005646_abnormal_pituitary_gland1.33032056
52MP0008004_abnormal_stomach_pH1.32975805
53MP0000428_abnormal_craniofacial_morphol1.32911845
54MP0004270_analgesia1.32437079
55MP0001905_abnormal_dopamine_level1.31383378
56MP0000631_abnormal_neuroendocrine_gland1.30943075
57MP0003635_abnormal_synaptic_transmissio1.30744523
58MP0002102_abnormal_ear_morphology1.30657940
59MP0000013_abnormal_adipose_tissue1.29827108
60MP0001968_abnormal_touch/_nociception1.27531317
61MP0002557_abnormal_social/conspecific_i1.27310080
62MP0003942_abnormal_urinary_system1.26933465
63MP0005330_cardiomyopathy1.26816894
64MP0003646_muscle_fatigue1.26615000
65MP0008789_abnormal_olfactory_epithelium1.26058159
66MP0003705_abnormal_hypodermis_morpholog1.25677320
67MP0004859_abnormal_synaptic_plasticity1.25243652
68MP0009697_abnormal_copulation1.24588820
69MP0004742_abnormal_vestibular_system1.23627958
70MP0002092_abnormal_eye_morphology1.23127891
71MP0003011_delayed_dark_adaptation1.22651943
72MP0004858_abnormal_nervous_system1.22401108
73MP0002234_abnormal_pharynx_morphology1.22282600
74MP0002090_abnormal_vision1.22050484
75MP0002653_abnormal_ependyma_morphology1.21945329
76MP0006072_abnormal_retinal_apoptosis1.21810305
77MP0002697_abnormal_eye_size1.21639105
78MP0001984_abnormal_olfaction1.21539216
79MP0003279_aneurysm1.21122619
80MP0001529_abnormal_vocalization1.20786593
81MP0004272_abnormal_basement_membrane1.20434292
82MP0009745_abnormal_behavioral_response1.19870889
83MP0003566_abnormal_cell_adhesion1.19524398
84MP0000537_abnormal_urethra_morphology1.19020351
85MP0003755_abnormal_palate_morphology1.18060759
86MP0005275_abnormal_skin_tensile1.18047945
87MP0003300_gastrointestinal_ulcer1.17882504
88MP0005253_abnormal_eye_physiology1.17636727
89MP0000538_abnormal_urinary_bladder1.17280283
90MP0002063_abnormal_learning/memory/cond1.16935541
91MP0006054_spinal_hemorrhage1.14111490
92MP0005171_absent_coat_pigmentation1.13874849
93MP0002736_abnormal_nociception_after1.13058237
94MP0001324_abnormal_eye_pigmentation1.13038541
95MP0001440_abnormal_grooming_behavior1.11693318
96MP0004215_abnormal_myocardial_fiber1.10327107
97MP0000467_abnormal_esophagus_morphology1.09916290
98MP0000534_abnormal_ureter_morphology1.08516668
99MP0002177_abnormal_outer_ear1.08217690
100MP0001293_anophthalmia1.07948595
101MP0004087_abnormal_muscle_fiber1.07680015
102MP0002067_abnormal_sensory_capabilities1.07598647
103MP0001486_abnormal_startle_reflex1.06837771
104MP0002064_seizures1.06826901
105MP0002098_abnormal_vibrissa_morphology1.06602750
106MP0000026_abnormal_inner_ear1.06549978
107MP0005620_abnormal_muscle_contractility1.06548501
108MP0005508_abnormal_skeleton_morphology1.06098716
109MP0000432_abnormal_head_morphology1.06042911
110MP0005391_vision/eye_phenotype1.05628723
111MP0003283_abnormal_digestive_organ1.05344686
112MP0002972_abnormal_cardiac_muscle1.04817098
113MP0000579_abnormal_nail_morphology1.04265539
114MP0004145_abnormal_muscle_electrophysio1.03837641
115MP0009046_muscle_twitch1.03073339
116MP0002184_abnormal_innervation1.03014296
117MP0002896_abnormal_bone_mineralization1.02357526
118MP0001340_abnormal_eyelid_morphology1.02202155
119MP0004142_abnormal_muscle_tone1.01482446
120MP0002272_abnormal_nervous_system0.98622858
121MP0009384_cardiac_valve_regurgitation0.98569461
122MP0005394_taste/olfaction_phenotype0.97627747
123MP0005499_abnormal_olfactory_system0.97627747
124MP0002282_abnormal_trachea_morphology0.97459848
125MP0001664_abnormal_digestion0.96386030
126MP0000747_muscle_weakness0.95087716
127MP0005423_abnormal_somatic_nervous0.94722429
128MP0002269_muscular_atrophy0.94107468
129MP0006138_congestive_heart_failure0.93223325
130MP0001501_abnormal_sleep_pattern0.93175430
131MP0001661_extended_life_span0.92131038
132MP0002116_abnormal_craniofacial_bone0.91493247
133MP0005085_abnormal_gallbladder_physiolo0.89233107
134MP0000647_abnormal_sebaceous_gland0.89172680
135MP0002752_abnormal_somatic_nervous0.88799308
136MP0002751_abnormal_autonomic_nervous0.88148147
137MP0000733_abnormal_muscle_development0.87241391
138MP0008775_abnormal_heart_ventricle0.86531100
139MP0010678_abnormal_skin_adnexa0.85971593
140MP0000613_abnormal_salivary_gland0.85462066
141MP0002882_abnormal_neuron_morphology0.84657298
142MP0002295_abnormal_pulmonary_circulatio0.84177344
143MP0005377_hearing/vestibular/ear_phenot0.83384495
144MP0003878_abnormal_ear_physiology0.83384495
145MP0002233_abnormal_nose_morphology0.81831255
146MP0000372_irregular_coat_pigmentation0.81800776
147MP0003137_abnormal_impulse_conducting0.80708621
148MP0001919_abnormal_reproductive_system0.79819220
149MP0005360_urolithiasis0.79567142
150MP0002108_abnormal_muscle_morphology0.79408791
151MP0004885_abnormal_endolymph0.78243522
152MP0000750_abnormal_muscle_regeneration0.77647060
153MP0010630_abnormal_cardiac_muscle0.77237363
154MP0001286_abnormal_eye_development0.77093895
155MP0000759_abnormal_skeletal_muscle0.76620568
156MP0010771_integument_phenotype0.76494134
157MP0005193_abnormal_anterior_eye0.75978226
158MP0003935_abnormal_craniofacial_develop0.75761163
159MP0002938_white_spotting0.75559465
160MP0001970_abnormal_pain_threshold0.75449329
161MP0005408_hypopigmentation0.73810630
162MP0003091_abnormal_cell_migration0.72191129
163MP0005195_abnormal_posterior_eye0.69530276
164MP0002877_abnormal_melanocyte_morpholog0.69002582
165MP0000163_abnormal_cartilage_morphology0.66273931
166MP0004085_abnormal_heartbeat0.65815533

Predicted human phenotypes

RankGene SetZ-score
1Fragile nails (HP:0001808)4.89537762
2Aplasia involving bones of the extremities (HP:0009825)4.72069088
3Aplasia involving bones of the upper limbs (HP:0009823)4.72069088
4Aplasia of the phalanges of the hand (HP:0009802)4.72069088
5Protrusio acetabuli (HP:0003179)4.46643826
6Exercise-induced muscle cramps (HP:0003710)3.91804273
7Vascular tortuosity (HP:0004948)3.45007978
8Concave nail (HP:0001598)3.38224785
9Arterial tortuosity (HP:0005116)3.38142266
10Aortic aneurysm (HP:0004942)3.28323455
11Vertebral compression fractures (HP:0002953)3.19393779
12Cervical subluxation (HP:0003308)3.11158636
13Choroideremia (HP:0001139)2.91657401
14Muscle hypertrophy of the lower extremities (HP:0008968)2.90551962
15Onycholysis (HP:0001806)2.87045674
16Fibular aplasia (HP:0002990)2.85609411
17Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.77406335
18Acute necrotizing encephalopathy (HP:0006965)2.75638411
19Hypothermia (HP:0002045)2.73412919
20Amelogenesis imperfecta (HP:0000705)2.71003061
21Focal motor seizures (HP:0011153)2.70224997
22Abnormality of the phalanges of the 2nd finger (HP:0009541)2.65645287
23Parakeratosis (HP:0001036)2.65224404
24Broad metatarsal (HP:0001783)2.65109895
25Right ventricular cardiomyopathy (HP:0011663)2.65017089
26Woolly hair (HP:0002224)2.64763777
27Calf muscle hypertrophy (HP:0008981)2.61620780
28Abnormality of the axillary hair (HP:0100134)2.60728508
29Abnormality of secondary sexual hair (HP:0009888)2.60728508
30Bundle branch block (HP:0011710)2.58780829
31Progressive macrocephaly (HP:0004481)2.52325415
32Abnormality of the fovea (HP:0000493)2.52304923
33Aplasia/hypoplasia of the uterus (HP:0008684)2.50380105
34Abnormality of the phalanges of the 5th finger (HP:0004213)2.50040815
35Myoglobinuria (HP:0002913)2.49699829
36Congenital, generalized hypertrichosis (HP:0004540)2.46464339
37Premature rupture of membranes (HP:0001788)2.46208148
38Type 1 muscle fiber predominance (HP:0003803)2.45709420
39Abnormality of the middle phalanges of the toes (HP:0010183)2.45414975
40Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.43580601
41Aortic dissection (HP:0002647)2.40966227
42Progressive cerebellar ataxia (HP:0002073)2.39231468
43Sleep apnea (HP:0010535)2.38951447
44Short hallux (HP:0010109)2.37035295
45Nephrogenic diabetes insipidus (HP:0009806)2.32851884
46Abnormal hemoglobin (HP:0011902)2.31754721
47Vaginal atresia (HP:0000148)2.30350762
48Abnormality of dentin (HP:0010299)2.28567629
49Aplasia cutis congenita (HP:0001057)2.28263247
50Abnormal mitochondria in muscle tissue (HP:0008316)2.28112361
51Genital tract atresia (HP:0001827)2.27067529
52Absent eyebrow (HP:0002223)2.26014879
53Mitochondrial inheritance (HP:0001427)2.25773121
54Abnormality of the calf musculature (HP:0001430)2.25469327
55Hepatoblastoma (HP:0002884)2.24246497
56Optic disc pallor (HP:0000543)2.23859213
57Nasolacrimal duct obstruction (HP:0000579)2.22981882
58Short nail (HP:0001799)2.20280718
59Abnormality of the lacrimal duct (HP:0011481)2.19214046
60Ridged nail (HP:0001807)2.19147489
61Ventricular tachycardia (HP:0004756)2.17680939
62Microglossia (HP:0000171)2.17021322
63Milia (HP:0001056)2.16901379
64Coronal craniosynostosis (HP:0004440)2.15585608
65Hyporeflexia of lower limbs (HP:0002600)2.15201200
66Lip pit (HP:0100267)2.14867064
67Scotoma (HP:0000575)2.14662422
68Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14472972
69Symphalangism affecting the phalanges of the hand (HP:0009773)2.14125012
70Hypoparathyroidism (HP:0000829)2.14013980
71Abnormality of the nasolacrimal system (HP:0000614)2.11731138
72Abnormality of the 2nd finger (HP:0004100)2.11524352
73Medial flaring of the eyebrow (HP:0010747)2.10286998
74Atrophic scars (HP:0001075)2.10024018
75Bronchomalacia (HP:0002780)2.08402342
76Hypoplasia of the uterus (HP:0000013)2.08193240
77Osteolytic defects of the hand bones (HP:0009699)2.07785162
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.07785162
79Ventricular fibrillation (HP:0001663)2.07168836
80Biconcave vertebral bodies (HP:0004586)2.07015484
81Hypopigmentation of the fundus (HP:0007894)2.06806766
82Shallow orbits (HP:0000586)2.06670721
83Renal Fanconi syndrome (HP:0001994)2.05781105
84Hyperthyroidism (HP:0000836)2.05537925
85Gait imbalance (HP:0002141)2.05432414
86Abnormal ciliary motility (HP:0012262)2.04134563
87True hermaphroditism (HP:0010459)2.01922434
88Congenital sensorineural hearing impairment (HP:0008527)2.01443066
89Curly hair (HP:0002212)2.01175284
90Aplasia/Hypoplasia of the hallux (HP:0008362)2.00561089
91Rhinitis (HP:0012384)1.99727486
92Hypodontia (HP:0000668)1.99463960
93Congenital primary aphakia (HP:0007707)1.94262730
94Rimmed vacuoles (HP:0003805)1.94194358
95Sudden death (HP:0001699)1.93624983
96Hypoplastic left heart (HP:0004383)1.93439462
97Reticulocytopenia (HP:0001896)1.88768864
98Asymmetric septal hypertrophy (HP:0001670)1.88124871
99Morphological abnormality of the middle ear (HP:0008609)1.87835947
100Thickened helices (HP:0000391)1.86815639
101Hypotrichosis (HP:0001006)1.86486451
102Abnormality of renal resorption (HP:0011038)1.84709320
103Hypoplasia of the iris (HP:0007676)1.84019456
104Renal dysplasia (HP:0000110)1.82354775
105Increased hepatocellular lipid droplets (HP:0006565)1.81187603
106Beaking of vertebral bodies (HP:0004568)1.81033337
107Wormian bones (HP:0002645)1.79894844
108Vertebral arch anomaly (HP:0008438)1.79579775
109Abnormal respiratory motile cilium physiology (HP:0012261)1.79547375
110Acute encephalopathy (HP:0006846)1.79392122
111Dilated cardiomyopathy (HP:0001644)1.79192548
112Broad-based gait (HP:0002136)1.78067919
113Action tremor (HP:0002345)1.76940376
114Plantar hyperkeratosis (HP:0007556)1.76405165
115Limb dystonia (HP:0002451)1.75554464
116Hypoglycemic seizures (HP:0002173)1.75528852
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75487594
118Lipoatrophy (HP:0100578)1.75454856
119Hyperinsulinemic hypoglycemia (HP:0000825)1.75235433
120Exercise-induced myalgia (HP:0003738)1.75108269
121Spinal rigidity (HP:0003306)1.73759234
122Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73180024
123Natal tooth (HP:0000695)1.72585883
124Polyphagia (HP:0002591)1.71947991
125Down-sloping shoulders (HP:0200021)1.70475325
126Failure to thrive in infancy (HP:0001531)1.70253757
127Mitral stenosis (HP:0001718)1.70095709
128Aplasia/Hypoplasia of the lens (HP:0008063)1.69894105
129Cutaneous finger syndactyly (HP:0010554)1.69619112
130Absent frontal sinuses (HP:0002688)1.69396901
131Pancreatic cysts (HP:0001737)1.67991088
132Abnormal respiratory epithelium morphology (HP:0012253)1.67699804
133Abnormal respiratory motile cilium morphology (HP:0005938)1.67699804
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.67640153
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67640153
136Advanced eruption of teeth (HP:0006288)1.67210124
137Neonatal short-limb short stature (HP:0008921)1.66233786
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.66052142
139Absent/shortened dynein arms (HP:0200106)1.66052142
140Renal tubular dysfunction (HP:0000124)1.65934214
141Overgrowth (HP:0001548)1.65856781
142Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64645627
143Mixed hearing impairment (HP:0000410)1.64535747
144Intrahepatic cholestasis (HP:0001406)1.64469439
145Tracheomalacia (HP:0002779)1.64309721
146Aplasia/Hypoplasia of the fibula (HP:0006492)1.64299975
147Abnormal atrioventricular conduction (HP:0005150)1.64177429
148Megalencephaly (HP:0001355)1.64176550
149Abnormality of molar (HP:0011077)1.63077836
150Abnormality of molar morphology (HP:0011070)1.63077836
151Short humerus (HP:0005792)1.62000837
152Mildly elevated creatine phosphokinase (HP:0008180)1.60431909
153Pulmonary artery stenosis (HP:0004415)1.60286973
154Heart block (HP:0012722)1.57810616
155Broad foot (HP:0001769)1.57698155
156Bladder diverticulum (HP:0000015)1.57629287
157Aplasia/Hypoplasia of the tongue (HP:0010295)1.57412702
158Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.57298278
159Muscle fiber inclusion bodies (HP:0100299)1.57295894
160Turricephaly (HP:0000262)1.54888554
161Rhizomelia (HP:0008905)1.54832338
162EMG: myopathic abnormalities (HP:0003458)1.54670367
163Left ventricular hypertrophy (HP:0001712)1.54203025
164Abdominal situs inversus (HP:0003363)1.54095452
165Abnormality of abdominal situs (HP:0011620)1.54095452
166Ankle contracture (HP:0006466)1.53087657
167Nemaline bodies (HP:0003798)1.52968065
168Occipital encephalocele (HP:0002085)1.50452324
169Ulnar bowing (HP:0003031)1.49542156
170Abnormality of permanent molar morphology (HP:0011071)1.49502260
171Abnormality of the dental root (HP:0006486)1.49502260
172Taurodontia (HP:0000679)1.49502260
173Atrial fibrillation (HP:0005110)1.48813161
174Dental crowding (HP:0000678)1.48720301
175Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.48669010
176Abnormality of the acetabulum (HP:0003170)1.48615373
177Limited hip movement (HP:0008800)1.45270127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.11942239
2TLK14.00991382
3STK393.27872319
4OXSR12.71643634
5EPHB22.47019632
6AKT32.43923205
7DDR22.17655890
8MST42.12565054
9EPHA22.12268057
10MAP2K71.97576183
11PDGFRA1.95119576
12EPHB11.92267538
13PHKG21.92040052
14PHKG11.92040052
15PRKD31.87265642
16CDK191.68633013
17MST1R1.66670435
18MKNK21.65378634
19MYLK1.65139576
20GRK71.64541673
21MAPK131.64178533
22LIMK11.62923693
23WNK41.62096040
24TESK11.50458373
25EPHA41.46133941
26LMTK21.40658325
27NTRK21.39916531
28SRPK11.37534527
29FGFR21.34044388
30MAPKAPK51.31063132
31PLK21.30927640
32NUAK11.28317952
33LATS21.28018177
34IRAK21.26219162
35DMPK1.25512057
36PRPF4B1.25265525
37FRK1.24629270
38PAK41.22989338
39OBSCN1.21773611
40CAMK1G1.21080139
41MKNK11.20075060
42NTRK31.18396842
43TNIK1.17466836
44BMPR21.17244714
45MAP3K41.15719989
46GRK51.15283519
47LATS11.14321974
48CAMK2A1.10548249
49NME11.09268966
50SGK21.07940899
51PTK21.07559854
52CAMK2B1.05282348
53UHMK11.02349411
54PINK11.00936935
55PDK20.99930405
56SGK4940.99490801
57SGK2230.99490801
58ERBB30.99179054
59STK38L0.98292494
60CDK80.97640580
61CSNK1A1L0.97227993
62CAMK1D0.96549578
63ROCK20.94138756
64MAP3K120.93533048
65MUSK0.93252291
66FER0.92642830
67PAK20.91612652
68ERBB40.91033813
69DYRK30.90078168
70PRKCE0.88979338
71ADRBK10.88868808
72YES10.85533043
73BMX0.85519001
74CSNK1G10.85434954
75MARK10.85148989
76CDK30.82918211
77ROCK10.81472622
78RIPK10.80276973
79DYRK1A0.78900853
80PASK0.77507983
81GRK10.75508894
82PKN10.74619144
83STK110.73523790
84NEK60.73181701
85TGFBR20.70331263
86PRKD20.70211672
87MAPK120.68256782
88MAPK150.66893837
89MAP3K20.65713823
90CSNK1G30.64474143
91STK30.64071194
92PBK0.63659262
93BMPR1B0.63146106
94TGFBR10.62314275
95PNCK0.61643957
96CAMK2D0.60561364
97RPS6KA40.60520615
98PRKAA10.60054892
99ADRBK20.59935142
100NEK90.58723634
101CAMK2G0.58102614
102FGFR10.58084604
103MAP2K40.57280799
104MAP3K30.56892384
105VRK10.55762651
106PAK60.55484479
107PRKCG0.53841803
108DYRK20.53356698
109TRPM70.51626335
110WNK30.51409653
111CSNK1G20.50933169
112CDK50.50689565
113MAPKAPK30.50617628
114TTK0.50235055
115KSR10.49060869
116EEF2K0.48839668
117PRKACA0.48008138
118MINK10.46521282
119GSK3A0.45899931
120AKT20.44999048
121PIK3CA0.44464664
122TYRO30.44062209
123MOS0.44012655
124TRIM280.43597828
125MET0.42794098
126NEK10.42274679
127FGR0.42033883
128DYRK1B0.41982553
129MTOR0.41682880
130PDGFRB0.41332897
131BRAF0.40525714
132ARAF0.39685869
133STK380.38840852
134PAK30.38597056
135SIK30.38259758
136TIE10.37484548
137SGK30.37122016
138PRKG10.37023267
139ERBB20.35339935
140MAP2K20.35205302
141EPHA30.34853491
142PRKAA20.34843004
143STK240.34801241
144MAP3K70.33309923
145PRKD10.33081930
146TTN0.32048394
147NTRK10.31378302
148BCR0.30078852
149SGK10.29939751

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.68938433
2Ribosome_Homo sapiens_hsa030102.96897632
3Parkinsons disease_Homo sapiens_hsa050122.78385531
4Nicotine addiction_Homo sapiens_hsa050332.76856103
5Alzheimers disease_Homo sapiens_hsa050102.51176598
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.32986128
7Phenylalanine metabolism_Homo sapiens_hsa003602.21720585
8Cardiac muscle contraction_Homo sapiens_hsa042602.20697987
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14068041
10Huntingtons disease_Homo sapiens_hsa050162.07705426
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04618284
12Basal cell carcinoma_Homo sapiens_hsa052172.00429317
13Hedgehog signaling pathway_Homo sapiens_hsa043401.92556460
14Steroid biosynthesis_Homo sapiens_hsa001001.85978696
15Histidine metabolism_Homo sapiens_hsa003401.84491214
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83653367
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.81077716
18Tyrosine metabolism_Homo sapiens_hsa003501.76667283
19Axon guidance_Homo sapiens_hsa043601.76631346
20Serotonergic synapse_Homo sapiens_hsa047261.74767067
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73705770
22beta-Alanine metabolism_Homo sapiens_hsa004101.71759716
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70744570
24Propanoate metabolism_Homo sapiens_hsa006401.69543657
25Collecting duct acid secretion_Homo sapiens_hsa049661.69136673
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.65138364
27Melanogenesis_Homo sapiens_hsa049161.64616136
28Fatty acid degradation_Homo sapiens_hsa000711.61608875
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59562807
30Long-term depression_Homo sapiens_hsa047301.55241848
31Amphetamine addiction_Homo sapiens_hsa050311.55183232
32Sphingolipid metabolism_Homo sapiens_hsa006001.54574589
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54516763
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53893033
35Pyruvate metabolism_Homo sapiens_hsa006201.53295350
36Synaptic vesicle cycle_Homo sapiens_hsa047211.53158544
37Fatty acid metabolism_Homo sapiens_hsa012121.51169781
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.50061291
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48233219
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46030903
41Vibrio cholerae infection_Homo sapiens_hsa051101.45380334
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44984719
43Renin secretion_Homo sapiens_hsa049241.43490181
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42345063
45Cocaine addiction_Homo sapiens_hsa050301.42020401
46Arginine and proline metabolism_Homo sapiens_hsa003301.40868990
47Adherens junction_Homo sapiens_hsa045201.40726397
48Taste transduction_Homo sapiens_hsa047421.40188671
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37192721
50Retinol metabolism_Homo sapiens_hsa008301.36979412
51Salivary secretion_Homo sapiens_hsa049701.36163174
52Carbon metabolism_Homo sapiens_hsa012001.35284098
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32556061
54Biosynthesis of amino acids_Homo sapiens_hsa012301.31710640
55Butanoate metabolism_Homo sapiens_hsa006501.30427374
56Glutamatergic synapse_Homo sapiens_hsa047241.29142802
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28738132
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27494173
59Gastric acid secretion_Homo sapiens_hsa049711.27005404
60Circadian rhythm_Homo sapiens_hsa047101.26203459
61GABAergic synapse_Homo sapiens_hsa047271.26053438
62Wnt signaling pathway_Homo sapiens_hsa043101.25925769
63Dilated cardiomyopathy_Homo sapiens_hsa054141.25345651
64Bile secretion_Homo sapiens_hsa049761.24609944
65Dopaminergic synapse_Homo sapiens_hsa047281.22953898
66Calcium signaling pathway_Homo sapiens_hsa040201.22371613
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21889168
68Circadian entrainment_Homo sapiens_hsa047131.20881387
69Hippo signaling pathway_Homo sapiens_hsa043901.20598738
70ECM-receptor interaction_Homo sapiens_hsa045121.16184516
71Morphine addiction_Homo sapiens_hsa050321.15003077
72Peroxisome_Homo sapiens_hsa041461.11667165
73Long-term potentiation_Homo sapiens_hsa047201.09617462
74Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08307972
75Cysteine and methionine metabolism_Homo sapiens_hsa002701.05130952
76Chemical carcinogenesis_Homo sapiens_hsa052041.04732794
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02023674
78Oxytocin signaling pathway_Homo sapiens_hsa049211.00365356
79Arginine biosynthesis_Homo sapiens_hsa002201.00304493
80GnRH signaling pathway_Homo sapiens_hsa049120.99345691
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98830818
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.98449406
83Gap junction_Homo sapiens_hsa045400.97977382
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96551040
85Cholinergic synapse_Homo sapiens_hsa047250.96053099
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.93778603
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93698581
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90800185
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90794107
90Lysine degradation_Homo sapiens_hsa003100.88056532
91Phototransduction_Homo sapiens_hsa047440.87991411
92Olfactory transduction_Homo sapiens_hsa047400.87250179
93Arachidonic acid metabolism_Homo sapiens_hsa005900.87182951
94Pentose phosphate pathway_Homo sapiens_hsa000300.86221641
95Fructose and mannose metabolism_Homo sapiens_hsa000510.84560728
96cAMP signaling pathway_Homo sapiens_hsa040240.82558593
97Tryptophan metabolism_Homo sapiens_hsa003800.82511012
98Ether lipid metabolism_Homo sapiens_hsa005650.82353256
99Glutathione metabolism_Homo sapiens_hsa004800.82141825
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81448255
101Fatty acid elongation_Homo sapiens_hsa000620.80418801
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.79413623
103Complement and coagulation cascades_Homo sapiens_hsa046100.79398874
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78278219
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77091654
106Insulin secretion_Homo sapiens_hsa049110.77010559
107PPAR signaling pathway_Homo sapiens_hsa033200.76349442
108Protein export_Homo sapiens_hsa030600.74785259
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73806382
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73662619
111AMPK signaling pathway_Homo sapiens_hsa041520.72075114
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70946756
113Tight junction_Homo sapiens_hsa045300.69300139
114Fatty acid biosynthesis_Homo sapiens_hsa000610.69244509
115Dorso-ventral axis formation_Homo sapiens_hsa043200.68746749
116Glucagon signaling pathway_Homo sapiens_hsa049220.66982560
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65617794
118Ovarian steroidogenesis_Homo sapiens_hsa049130.64578432
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64044913
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63944912
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63869579
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63751370
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63371650
124ErbB signaling pathway_Homo sapiens_hsa040120.63164148
125TGF-beta signaling pathway_Homo sapiens_hsa043500.63156080
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.62334250
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61189682
128Ras signaling pathway_Homo sapiens_hsa040140.61085775
129Mineral absorption_Homo sapiens_hsa049780.58499456
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58400349
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57433910
132Pancreatic secretion_Homo sapiens_hsa049720.55909680
133Protein digestion and absorption_Homo sapiens_hsa049740.55383731
134Estrogen signaling pathway_Homo sapiens_hsa049150.55376356
135Choline metabolism in cancer_Homo sapiens_hsa052310.54360223
136Sulfur relay system_Homo sapiens_hsa041220.54201324
137Small cell lung cancer_Homo sapiens_hsa052220.54073066
138Melanoma_Homo sapiens_hsa052180.52657827
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51968726
140N-Glycan biosynthesis_Homo sapiens_hsa005100.51426461
141Vitamin digestion and absorption_Homo sapiens_hsa049770.51216197
142Renal cell carcinoma_Homo sapiens_hsa052110.50576502
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.49608356
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.49562295
145Thyroid cancer_Homo sapiens_hsa052160.47719800
146Focal adhesion_Homo sapiens_hsa045100.47672844
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47665113
148Linoleic acid metabolism_Homo sapiens_hsa005910.47288719
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45755569
150Caffeine metabolism_Homo sapiens_hsa002320.44939480
151ABC transporters_Homo sapiens_hsa020100.44670262
152Vitamin B6 metabolism_Homo sapiens_hsa007500.44629389
153Bladder cancer_Homo sapiens_hsa052190.43838429
154Proteoglycans in cancer_Homo sapiens_hsa052050.42714346
155Starch and sucrose metabolism_Homo sapiens_hsa005000.42665953
156Metabolic pathways_Homo sapiens_hsa011000.42162948
157Sulfur metabolism_Homo sapiens_hsa009200.40689755
158Pathways in cancer_Homo sapiens_hsa052000.38745317
159Endometrial cancer_Homo sapiens_hsa052130.37923840
160RNA polymerase_Homo sapiens_hsa030200.37749657
161Prostate cancer_Homo sapiens_hsa052150.37241064
162alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37013919
163Rap1 signaling pathway_Homo sapiens_hsa040150.36174683
164Phospholipase D signaling pathway_Homo sapiens_hsa040720.34846321
165MAPK signaling pathway_Homo sapiens_hsa040100.34511508
166Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32694090

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