

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 6.29170043 |
| 2 | vocalization behavior (GO:0071625) | 6.22492703 |
| 3 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.92028418 |
| 4 | locomotory exploration behavior (GO:0035641) | 5.84323981 |
| 5 | synaptic vesicle exocytosis (GO:0016079) | 5.51431655 |
| 6 | synaptic vesicle maturation (GO:0016188) | 5.34822378 |
| 7 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.32737676 |
| 8 | regulation of glutamate receptor signaling pathway (GO:1900449) | 5.19522965 |
| 9 | neuron cell-cell adhesion (GO:0007158) | 5.05029226 |
| 10 | protein localization to synapse (GO:0035418) | 4.98145960 |
| 11 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.94129697 |
| 12 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.94026761 |
| 13 | glutamate secretion (GO:0014047) | 4.92360688 |
| 14 | neurotransmitter secretion (GO:0007269) | 4.81909611 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.80277214 |
| 16 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.66936444 |
| 17 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.62522025 |
| 18 | neuronal action potential propagation (GO:0019227) | 4.56448489 |
| 19 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.53866786 |
| 20 | exploration behavior (GO:0035640) | 4.48622755 |
| 21 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.43863475 |
| 22 | gamma-aminobutyric acid transport (GO:0015812) | 4.42193676 |
| 23 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.41609076 |
| 24 | regulation of synapse structural plasticity (GO:0051823) | 4.28561383 |
| 25 | regulation of synaptic vesicle transport (GO:1902803) | 4.28108423 |
| 26 | neuron-neuron synaptic transmission (GO:0007270) | 4.25187268 |
| 27 | glutamate receptor signaling pathway (GO:0007215) | 4.17710300 |
| 28 | synaptic transmission, glutamatergic (GO:0035249) | 4.15655103 |
| 29 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 4.06202035 |
| 30 | positive regulation of membrane potential (GO:0045838) | 4.02343748 |
| 31 | long-term memory (GO:0007616) | 4.01633195 |
| 32 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.00839304 |
| 33 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.94798412 |
| 34 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.89416514 |
| 35 | positive regulation of synapse maturation (GO:0090129) | 3.88936792 |
| 36 | neurotransmitter transport (GO:0006836) | 3.84373766 |
| 37 | regulation of postsynaptic membrane potential (GO:0060078) | 3.83996772 |
| 38 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.83691906 |
| 39 | layer formation in cerebral cortex (GO:0021819) | 3.82943862 |
| 40 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.78365437 |
| 41 | dendritic spine morphogenesis (GO:0060997) | 3.77755212 |
| 42 | long-term synaptic potentiation (GO:0060291) | 3.71676504 |
| 43 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.69766834 |
| 44 | response to histamine (GO:0034776) | 3.68875895 |
| 45 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.68262308 |
| 46 | transmission of nerve impulse (GO:0019226) | 3.66897175 |
| 47 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.65418719 |
| 48 | proline transport (GO:0015824) | 3.62731772 |
| 49 | regulation of synaptic plasticity (GO:0048167) | 3.62620474 |
| 50 | regulation of neurotransmitter levels (GO:0001505) | 3.62399598 |
| 51 | striatum development (GO:0021756) | 3.57257592 |
| 52 | insulin secretion (GO:0030073) | 3.56034040 |
| 53 | neuron recognition (GO:0008038) | 3.53739581 |
| 54 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.52223101 |
| 55 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.51924134 |
| 56 | presynaptic membrane assembly (GO:0097105) | 3.51655503 |
| 57 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.50652704 |
| 58 | postsynaptic membrane organization (GO:0001941) | 3.47467243 |
| 59 | activation of protein kinase A activity (GO:0034199) | 3.46338855 |
| 60 | startle response (GO:0001964) | 3.45762935 |
| 61 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.45428331 |
| 62 | behavioral fear response (GO:0001662) | 3.39272003 |
| 63 | behavioral defense response (GO:0002209) | 3.39272003 |
| 64 | auditory behavior (GO:0031223) | 3.36525675 |
| 65 | prepulse inhibition (GO:0060134) | 3.35903853 |
| 66 | behavioral response to cocaine (GO:0048148) | 3.34513695 |
| 67 | membrane hyperpolarization (GO:0060081) | 3.31921730 |
| 68 | regulation of neurotransmitter secretion (GO:0046928) | 3.31682897 |
| 69 | cellular potassium ion homeostasis (GO:0030007) | 3.30971339 |
| 70 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.26183841 |
| 71 | learning (GO:0007612) | 3.25048162 |
| 72 | membrane depolarization (GO:0051899) | 3.24093792 |
| 73 | response to auditory stimulus (GO:0010996) | 3.23745062 |
| 74 | presynaptic membrane organization (GO:0097090) | 3.23711678 |
| 75 | neuromuscular process controlling balance (GO:0050885) | 3.23101121 |
| 76 | sodium ion export (GO:0071436) | 3.21533354 |
| 77 | synapse assembly (GO:0007416) | 3.20973640 |
| 78 | serotonin metabolic process (GO:0042428) | 3.20853368 |
| 79 | neuronal ion channel clustering (GO:0045161) | 3.20691353 |
| 80 | fear response (GO:0042596) | 3.19545961 |
| 81 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.18004540 |
| 82 | positive regulation of synaptic transmission (GO:0050806) | 3.16952376 |
| 83 | positive regulation of neurotransmitter transport (GO:0051590) | 3.16922249 |
| 84 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.16645207 |
| 85 | regulation of glutamate secretion (GO:0014048) | 3.15443545 |
| 86 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.14833721 |
| 87 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.14547753 |
| 88 | intraspecies interaction between organisms (GO:0051703) | 3.13972088 |
| 89 | social behavior (GO:0035176) | 3.13972088 |
| 90 | regulation of neurotransmitter transport (GO:0051588) | 3.13576809 |
| 91 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235 | 3.12609113 |
| 92 | regulation of vesicle fusion (GO:0031338) | 3.12607403 |
| 93 | synaptic vesicle endocytosis (GO:0048488) | 3.12440448 |
| 94 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.11717672 |
| 95 | neuromuscular process controlling posture (GO:0050884) | 3.11419537 |
| 96 | axonal fasciculation (GO:0007413) | 3.10290730 |
| 97 | synaptic transmission (GO:0007268) | 3.08346572 |
| 98 | detection of calcium ion (GO:0005513) | 3.07384452 |
| 99 | synaptic transmission, dopaminergic (GO:0001963) | 3.06885700 |
| 100 | regulation of synaptic transmission (GO:0050804) | 3.06289273 |
| 101 | regulation of synapse maturation (GO:0090128) | 3.05769240 |
| 102 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.03264109 |
| 103 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.01287501 |
| 104 | regulation of female receptivity (GO:0045924) | 3.00771427 |
| 105 | potassium ion homeostasis (GO:0055075) | 2.98376870 |
| 106 | regulation of dendritic spine development (GO:0060998) | 2.98241868 |
| 107 | membrane depolarization during action potential (GO:0086010) | 2.97956969 |
| 108 | mating behavior (GO:0007617) | 2.95238520 |
| 109 | glycine transport (GO:0015816) | 2.94273476 |
| 110 | chemosensory behavior (GO:0007635) | 2.94113540 |
| 111 | L-amino acid import (GO:0043092) | 2.93894072 |
| 112 | cellular sodium ion homeostasis (GO:0006883) | 2.93042556 |
| 113 | negative regulation of dendrite development (GO:2000171) | 2.90497340 |
| 114 | potassium ion import (GO:0010107) | 2.89934888 |
| 115 | cell communication by electrical coupling (GO:0010644) | 2.89882458 |
| 116 | C4-dicarboxylate transport (GO:0015740) | 2.87793159 |
| 117 | primary amino compound metabolic process (GO:1901160) | 2.85834220 |
| 118 | alanine transport (GO:0032328) | 2.81596807 |
| 119 | righting reflex (GO:0060013) | 2.80583135 |
| 120 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.79598663 |
| 121 | cell communication involved in cardiac conduction (GO:0086065) | 2.77567797 |
| 122 | cAMP-mediated signaling (GO:0019933) | 2.77020388 |
| 123 | positive regulation of glycolytic process (GO:0045821) | 2.76650016 |
| 124 | dopamine transport (GO:0015872) | 2.73890446 |
| 125 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.73849854 |
| 126 | negative regulation of hormone metabolic process (GO:0032351) | 2.72365810 |
| 127 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.68088632 |
| 128 | cardiac conduction (GO:0061337) | 2.66561406 |
| 129 | signal release (GO:0023061) | 2.64307602 |
| 130 | neurotransmitter uptake (GO:0001504) | 2.64116878 |
| 131 | cellular ketone body metabolic process (GO:0046950) | 2.62704057 |
| 132 | regulation of type B pancreatic cell apoptotic process (GO:2000674) | 2.62452350 |
| 133 | cellular potassium ion transport (GO:0071804) | 2.58372769 |
| 134 | potassium ion transmembrane transport (GO:0071805) | 2.58372769 |
| 135 | regulation of heart rate by cardiac conduction (GO:0086091) | 2.56109410 |
| 136 | negative regulation of neurotransmitter transport (GO:0051589) | 2.55136575 |
| 137 | catecholamine transport (GO:0051937) | 2.54522149 |
| 138 | urinary tract smooth muscle contraction (GO:0014848) | 2.54319856 |
| 139 | calcium ion-dependent exocytosis (GO:0017156) | 2.51915480 |
| 140 | atrial cardiac muscle cell action potential (GO:0086014) | 2.49938936 |
| 141 | potassium ion transport (GO:0006813) | 2.49888591 |
| 142 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.49098752 |
| 143 | glycosphingolipid biosynthetic process (GO:0006688) | 2.47681091 |
| 144 | vesicle docking involved in exocytosis (GO:0006904) | 2.44432839 |
| 145 | cerebellar granule cell differentiation (GO:0021707) | 2.43062222 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.19648956 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.73864868 |
| 3 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.21557612 |
| 4 | * SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.15824887 |
| 5 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.10835588 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.72979654 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.72979654 |
| 8 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.72258618 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.65403624 |
| 10 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.62084472 |
| 11 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.59625058 |
| 12 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.58074453 |
| 13 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.53329998 |
| 14 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.51845392 |
| 15 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.48710633 |
| 16 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.48542474 |
| 17 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.47745364 |
| 18 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.39165952 |
| 19 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.33129405 |
| 20 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.21227769 |
| 21 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.18488913 |
| 22 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.15272296 |
| 23 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.15008448 |
| 24 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.13746835 |
| 25 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.05571229 |
| 26 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.02436613 |
| 27 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.00963488 |
| 28 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.98762913 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.95068352 |
| 30 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.92735495 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.89285392 |
| 32 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.78152029 |
| 33 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.78060797 |
| 34 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.76669247 |
| 35 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.71529198 |
| 36 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.70180444 |
| 37 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.68400551 |
| 38 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.60948339 |
| 39 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.56572806 |
| 40 | P300_19829295_ChIP-Seq_ESCs_Human | 1.51816841 |
| 41 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.49693310 |
| 42 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.49421462 |
| 43 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.49001854 |
| 44 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.45852756 |
| 45 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45686924 |
| 46 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.43465109 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40424282 |
| 48 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.39580306 |
| 49 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.37834221 |
| 50 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34835625 |
| 51 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.33440251 |
| 52 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.33359863 |
| 53 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.32512296 |
| 54 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.32447098 |
| 55 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.31499704 |
| 56 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.31282905 |
| 57 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.30980870 |
| 58 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.30878892 |
| 59 | AR_25329375_ChIP-Seq_VCAP_Human | 1.30723833 |
| 60 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.28761356 |
| 61 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.25087963 |
| 62 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.24814372 |
| 63 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.23761523 |
| 64 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.23392033 |
| 65 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.21848089 |
| 66 | FUS_26573619_Chip-Seq_HEK293_Human | 1.21381689 |
| 67 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.20982084 |
| 68 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.20685329 |
| 69 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.19720365 |
| 70 | * AR_19668381_ChIP-Seq_PC3_Human | 1.19338011 |
| 71 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.18549833 |
| 72 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.18033226 |
| 73 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.16915965 |
| 74 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.15558130 |
| 75 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.15558130 |
| 76 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.15128578 |
| 77 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.15088659 |
| 78 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.14942507 |
| 79 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.14846782 |
| 80 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.14540885 |
| 81 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.13797460 |
| 82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.13718333 |
| 83 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.13637606 |
| 84 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.12610229 |
| 85 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.12104432 |
| 86 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.11690199 |
| 87 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11629818 |
| 88 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.10001094 |
| 89 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.09873856 |
| 90 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.08721175 |
| 91 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.08464717 |
| 92 | VDR_22108803_ChIP-Seq_LS180_Human | 1.08288181 |
| 93 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.08188180 |
| 94 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.08188180 |
| 95 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 1.07819618 |
| 96 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.06988334 |
| 97 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.06784024 |
| 98 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.06027346 |
| 99 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.05807685 |
| 100 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05694096 |
| 101 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.05573519 |
| 102 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.05529134 |
| 103 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.05504205 |
| 104 | EWS_26573619_Chip-Seq_HEK293_Human | 1.05232922 |
| 105 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.05167980 |
| 106 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04942766 |
| 107 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.03638641 |
| 108 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.01789307 |
| 109 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.00440544 |
| 110 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.99945453 |
| 111 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.98737463 |
| 112 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.97450774 |
| 113 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.94328487 |
| 114 | JUN_21703547_ChIP-Seq_K562_Human | 0.94250496 |
| 115 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.93813102 |
| 116 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.93655219 |
| 117 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.92058124 |
| 118 | TP53_16413492_ChIP-PET_HCT116_Human | 0.91484519 |
| 119 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.90393665 |
| 120 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.89821859 |
| 121 | RXR_22108803_ChIP-Seq_LS180_Human | 0.88718321 |
| 122 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.88281350 |
| 123 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.87791278 |
| 124 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.87712356 |
| 125 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.87647929 |
| 126 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.85038781 |
| 127 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.83842783 |
| 128 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.83842783 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.21726700 |
| 2 | MP0003880_abnormal_central_pattern | 4.60851887 |
| 3 | MP0002822_catalepsy | 4.33477753 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 4.28217738 |
| 5 | MP0009745_abnormal_behavioral_response | 3.74211736 |
| 6 | MP0009046_muscle_twitch | 3.45816622 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.43525211 |
| 8 | MP0002064_seizures | 3.42073844 |
| 9 | MP0004270_analgesia | 3.23794860 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.97311835 |
| 11 | MP0001968_abnormal_touch/_nociception | 2.80341809 |
| 12 | MP0002272_abnormal_nervous_system | 2.70003294 |
| 13 | MP0001486_abnormal_startle_reflex | 2.66980738 |
| 14 | MP0001501_abnormal_sleep_pattern | 2.57914156 |
| 15 | MP0003195_calcinosis | 2.56975648 |
| 16 | MP0005423_abnormal_somatic_nervous | 2.51003465 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.49304038 |
| 18 | MP0002735_abnormal_chemical_nociception | 2.14049011 |
| 19 | MP0009780_abnormal_chondrocyte_physiolo | 2.13643207 |
| 20 | MP0001440_abnormal_grooming_behavior | 2.12188493 |
| 21 | MP0005646_abnormal_pituitary_gland | 2.06674715 |
| 22 | MP0002736_abnormal_nociception_after | 2.03925608 |
| 23 | MP0002067_abnormal_sensory_capabilities | 1.95417371 |
| 24 | MP0002733_abnormal_thermal_nociception | 1.90496985 |
| 25 | MP0008569_lethality_at_weaning | 1.90098996 |
| 26 | MP0001970_abnormal_pain_threshold | 1.87892930 |
| 27 | MP0002557_abnormal_social/conspecific_i | 1.80622405 |
| 28 | MP0005386_behavior/neurological_phenoty | 1.78323873 |
| 29 | MP0004924_abnormal_behavior | 1.78323873 |
| 30 | MP0002909_abnormal_adrenal_gland | 1.75264031 |
| 31 | MP0002184_abnormal_innervation | 1.71539371 |
| 32 | MP0003329_amyloid_beta_deposits | 1.69955934 |
| 33 | MP0001984_abnormal_olfaction | 1.64407522 |
| 34 | MP0003879_abnormal_hair_cell | 1.63310807 |
| 35 | MP0004811_abnormal_neuron_physiology | 1.61683070 |
| 36 | MP0001529_abnormal_vocalization | 1.59557706 |
| 37 | MP0003787_abnormal_imprinting | 1.58797904 |
| 38 | MP0006276_abnormal_autonomic_nervous | 1.58652968 |
| 39 | MP0001188_hyperpigmentation | 1.55472528 |
| 40 | MP0004858_abnormal_nervous_system | 1.45553818 |
| 41 | MP0000778_abnormal_nervous_system | 1.43058548 |
| 42 | MP0003122_maternal_imprinting | 1.40475950 |
| 43 | MP0002066_abnormal_motor_capabilities/c | 1.40135788 |
| 44 | MP0000955_abnormal_spinal_cord | 1.34282586 |
| 45 | MP0005645_abnormal_hypothalamus_physiol | 1.33353496 |
| 46 | MP0008877_abnormal_DNA_methylation | 1.31538217 |
| 47 | MP0002882_abnormal_neuron_morphology | 1.29966941 |
| 48 | MP0005379_endocrine/exocrine_gland_phen | 1.29828300 |
| 49 | MP0000013_abnormal_adipose_tissue | 1.28675721 |
| 50 | MP0004142_abnormal_muscle_tone | 1.26720937 |
| 51 | MP0004885_abnormal_endolymph | 1.25634702 |
| 52 | MP0003633_abnormal_nervous_system | 1.25090282 |
| 53 | MP0004147_increased_porphyrin_level | 1.24471782 |
| 54 | MP0001905_abnormal_dopamine_level | 1.24319862 |
| 55 | MP0002693_abnormal_pancreas_physiology | 1.19598667 |
| 56 | MP0002837_dystrophic_cardiac_calcinosis | 1.19385060 |
| 57 | MP0001502_abnormal_circadian_rhythm | 1.18007184 |
| 58 | MP0000462_abnormal_digestive_system | 1.17403800 |
| 59 | MP0001944_abnormal_pancreas_morphology | 1.13321656 |
| 60 | MP0001177_atelectasis | 1.10066688 |
| 61 | MP0008872_abnormal_physiological_respon | 1.09462575 |
| 62 | MP0003631_nervous_system_phenotype | 1.08399301 |
| 63 | MP0010386_abnormal_urinary_bladder | 1.01910388 |
| 64 | MP0000751_myopathy | 1.01203049 |
| 65 | MP0002152_abnormal_brain_morphology | 1.00735635 |
| 66 | MP0008874_decreased_physiological_sensi | 1.00272425 |
| 67 | MP0001765_abnormal_ion_homeostasis | 0.98304983 |
| 68 | MP0010329_abnormal_lipoprotein_level | 0.98166304 |
| 69 | MP0002069_abnormal_eating/drinking_beha | 0.97556597 |
| 70 | MP0001986_abnormal_taste_sensitivity | 0.97196563 |
| 71 | MP0003121_genomic_imprinting | 0.95541172 |
| 72 | MP0004085_abnormal_heartbeat | 0.95402838 |
| 73 | MP0002078_abnormal_glucose_homeostasis | 0.94769332 |
| 74 | MP0003868_abnormal_feces_composition | 0.89513838 |
| 75 | MP0003283_abnormal_digestive_organ | 0.89254992 |
| 76 | MP0005253_abnormal_eye_physiology | 0.86836264 |
| 77 | MP0000639_abnormal_adrenal_gland | 0.86689558 |
| 78 | MP0002876_abnormal_thyroid_physiology | 0.86617823 |
| 79 | MP0005535_abnormal_body_temperature | 0.85940069 |
| 80 | MP0002229_neurodegeneration | 0.85364211 |
| 81 | MP0005551_abnormal_eye_electrophysiolog | 0.84282398 |
| 82 | MP0001666_abnormal_nutrient_absorption | 0.81570804 |
| 83 | MP0004742_abnormal_vestibular_system | 0.80843347 |
| 84 | MP0005332_abnormal_amino_acid | 0.80749369 |
| 85 | MP0002090_abnormal_vision | 0.80234620 |
| 86 | MP0003183_abnormal_peptide_metabolism | 0.79562943 |
| 87 | MP0003953_abnormal_hormone_level | 0.78636951 |
| 88 | MP0006072_abnormal_retinal_apoptosis | 0.78580524 |
| 89 | MP0003632_abnormal_nervous_system | 0.78579379 |
| 90 | MP0004215_abnormal_myocardial_fiber | 0.78466974 |
| 91 | MP0001963_abnormal_hearing_physiology | 0.77854498 |
| 92 | MP0000569_abnormal_digit_pigmentation | 0.77247279 |
| 93 | MP0003690_abnormal_glial_cell | 0.76378975 |
| 94 | MP0005499_abnormal_olfactory_system | 0.75760328 |
| 95 | MP0005394_taste/olfaction_phenotype | 0.75760328 |
| 96 | MP0005085_abnormal_gallbladder_physiolo | 0.75595637 |
| 97 | MP0005365_abnormal_bile_salt | 0.75385097 |
| 98 | MP0004145_abnormal_muscle_electrophysio | 0.75031919 |
| 99 | MP0003075_altered_response_to | 0.74267759 |
| 100 | MP0001756_abnormal_urination | 0.73076268 |
| 101 | MP0000604_amyloidosis | 0.73030068 |
| 102 | MP0005448_abnormal_energy_balance | 0.72273378 |
| 103 | MP0004019_abnormal_vitamin_homeostasis | 0.71806777 |
| 104 | MP0000631_abnormal_neuroendocrine_gland | 0.70849481 |
| 105 | MP0002638_abnormal_pupillary_reflex | 0.70529830 |
| 106 | MP0003634_abnormal_glial_cell | 0.69844144 |
| 107 | MP0002163_abnormal_gland_morphology | 0.68297868 |
| 108 | MP0008775_abnormal_heart_ventricle | 0.67733286 |
| 109 | MP0004233_abnormal_muscle_weight | 0.66989073 |
| 110 | MP0004484_altered_response_of | 0.66508227 |
| 111 | MP0001664_abnormal_digestion | 0.66373594 |
| 112 | MP0008961_abnormal_basal_metabolism | 0.66275584 |
| 113 | MP0010234_abnormal_vibrissa_follicle | 0.65164680 |
| 114 | MP0002752_abnormal_somatic_nervous | 0.64631480 |
| 115 | MP0005409_darkened_coat_color | 0.62612234 |
| 116 | MP0003137_abnormal_impulse_conducting | 0.60178963 |
| 117 | MP0000920_abnormal_myelination | 0.58666051 |
| 118 | MP0001943_abnormal_respiration | 0.58441666 |
| 119 | MP0003123_paternal_imprinting | 0.57947766 |
| 120 | MP0004043_abnormal_pH_regulation | 0.53528838 |
| 121 | MP0005167_abnormal_blood-brain_barrier | 0.51445061 |
| 122 | MP0010770_preweaning_lethality | 0.51257495 |
| 123 | MP0002082_postnatal_lethality | 0.51257495 |
| 124 | MP0005623_abnormal_meninges_morphology | 0.50796357 |
| 125 | MP0010769_abnormal_survival | 0.50440862 |
| 126 | MP0001299_abnormal_eye_distance/ | 0.49911682 |
| 127 | MP0003956_abnormal_body_size | 0.49636877 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 9.21320035 |
| 2 | Myokymia (HP:0002411) | 6.44874471 |
| 3 | Focal seizures (HP:0007359) | 6.33998816 |
| 4 | Atonic seizures (HP:0010819) | 5.83891663 |
| 5 | Epileptic encephalopathy (HP:0200134) | 5.32562090 |
| 6 | Febrile seizures (HP:0002373) | 5.30562834 |
| 7 | Visual hallucinations (HP:0002367) | 5.13034985 |
| 8 | Absence seizures (HP:0002121) | 4.89937845 |
| 9 | Hypoglycemic seizures (HP:0002173) | 4.49472832 |
| 10 | Dialeptic seizures (HP:0011146) | 4.46798077 |
| 11 | Hyperinsulinemic hypoglycemia (HP:0000825) | 4.43477550 |
| 12 | Hyperventilation (HP:0002883) | 4.35687943 |
| 13 | Generalized tonic-clonic seizures (HP:0002069) | 4.27617888 |
| 14 | Progressive cerebellar ataxia (HP:0002073) | 4.08936787 |
| 15 | Hypoglycemic coma (HP:0001325) | 3.93999053 |
| 16 | Increased circulating renin level (HP:0000848) | 3.92191812 |
| 17 | Broad-based gait (HP:0002136) | 3.86080353 |
| 18 | Hypomagnesemia (HP:0002917) | 3.76443271 |
| 19 | Gaze-evoked nystagmus (HP:0000640) | 3.65986828 |
| 20 | Poor eye contact (HP:0000817) | 3.57045149 |
| 21 | Impaired social interactions (HP:0000735) | 3.56435862 |
| 22 | Abnormal social behavior (HP:0012433) | 3.56435862 |
| 23 | Action tremor (HP:0002345) | 3.53051145 |
| 24 | Dysdiadochokinesis (HP:0002075) | 3.37071031 |
| 25 | Progressive inability to walk (HP:0002505) | 3.35576050 |
| 26 | Truncal ataxia (HP:0002078) | 3.28369569 |
| 27 | Ketoacidosis (HP:0001993) | 3.23393221 |
| 28 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.23155552 |
| 29 | Abnormal eating behavior (HP:0100738) | 3.10494649 |
| 30 | Abnormality of magnesium homeostasis (HP:0004921) | 3.10412367 |
| 31 | Symptomatic seizures (HP:0011145) | 3.09579337 |
| 32 | Depression (HP:0000716) | 3.09300228 |
| 33 | Anxiety (HP:0000739) | 3.07169678 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.92874780 |
| 35 | Postural instability (HP:0002172) | 2.92555205 |
| 36 | Ankle clonus (HP:0011448) | 2.92545529 |
| 37 | Dysmetria (HP:0001310) | 2.89299558 |
| 38 | Metabolic alkalosis (HP:0200114) | 2.87481374 |
| 39 | Hypothermia (HP:0002045) | 2.83650815 |
| 40 | Hyperglycemia (HP:0003074) | 2.80687878 |
| 41 | Papilledema (HP:0001085) | 2.79921805 |
| 42 | Amblyopia (HP:0000646) | 2.79402020 |
| 43 | Excessive salivation (HP:0003781) | 2.77222802 |
| 44 | Drooling (HP:0002307) | 2.77222802 |
| 45 | Supranuclear gaze palsy (HP:0000605) | 2.77123807 |
| 46 | Resting tremor (HP:0002322) | 2.64659267 |
| 47 | Dysmetric saccades (HP:0000641) | 2.63987238 |
| 48 | Abnormal drinking behavior (HP:0030082) | 2.62794304 |
| 49 | Polydipsia (HP:0001959) | 2.62794304 |
| 50 | Late onset (HP:0003584) | 2.61673864 |
| 51 | Impaired smooth pursuit (HP:0007772) | 2.58727685 |
| 52 | Scanning speech (HP:0002168) | 2.57557573 |
| 53 | Status epilepticus (HP:0002133) | 2.57192908 |
| 54 | Mutism (HP:0002300) | 2.56908420 |
| 55 | Absent speech (HP:0001344) | 2.55710640 |
| 56 | Inability to walk (HP:0002540) | 2.54703459 |
| 57 | Abnormality of renin-angiotensin system (HP:0000847) | 2.52832732 |
| 58 | Torticollis (HP:0000473) | 2.51408129 |
| 59 | Epileptiform EEG discharges (HP:0011182) | 2.50358840 |
| 60 | Genetic anticipation (HP:0003743) | 2.49631373 |
| 61 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.48263786 |
| 62 | Bradykinesia (HP:0002067) | 2.46768126 |
| 63 | Type II lissencephaly (HP:0007260) | 2.41583583 |
| 64 | Polyphagia (HP:0002591) | 2.40674854 |
| 65 | EEG with generalized epileptiform discharges (HP:0011198) | 2.38450309 |
| 66 | Abnormality of calcium-phosphate metabolism (HP:0100530) | 2.37241163 |
| 67 | Intention tremor (HP:0002080) | 2.36668202 |
| 68 | Focal dystonia (HP:0004373) | 2.36262276 |
| 69 | Diplopia (HP:0000651) | 2.35840033 |
| 70 | Abnormality of binocular vision (HP:0011514) | 2.35840033 |
| 71 | Urinary urgency (HP:0000012) | 2.35400023 |
| 72 | Hemiplegia (HP:0002301) | 2.35115916 |
| 73 | Stereotypic behavior (HP:0000733) | 2.32322440 |
| 74 | Large for gestational age (HP:0001520) | 2.31951848 |
| 75 | Hemiparesis (HP:0001269) | 2.31415126 |
| 76 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.27561844 |
| 77 | Hypsarrhythmia (HP:0002521) | 2.26963158 |
| 78 | Fetal akinesia sequence (HP:0001989) | 2.26948391 |
| 79 | Spastic gait (HP:0002064) | 2.25312808 |
| 80 | Muscular hypotonia of the trunk (HP:0008936) | 2.24669069 |
| 81 | Limb dystonia (HP:0002451) | 2.23807665 |
| 82 | Generalized myoclonic seizures (HP:0002123) | 2.23583881 |
| 83 | Annular pancreas (HP:0001734) | 2.23106588 |
| 84 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.22564227 |
| 85 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.22564227 |
| 86 | Insidious onset (HP:0003587) | 2.21996783 |
| 87 | Termporal pattern (HP:0011008) | 2.21996783 |
| 88 | Impaired vibratory sensation (HP:0002495) | 2.20640918 |
| 89 | Blue irides (HP:0000635) | 2.20302458 |
| 90 | Abnormality of the lower motor neuron (HP:0002366) | 2.19823071 |
| 91 | Syncope (HP:0001279) | 2.18236337 |
| 92 | Pheochromocytoma (HP:0002666) | 2.18098644 |
| 93 | Cerebral inclusion bodies (HP:0100314) | 2.13734311 |
| 94 | Protruding tongue (HP:0010808) | 2.12370988 |
| 95 | Craniofacial dystonia (HP:0012179) | 2.09825994 |
| 96 | Neurofibrillary tangles (HP:0002185) | 2.07364618 |
| 97 | Gait ataxia (HP:0002066) | 2.04179849 |
| 98 | Ventricular fibrillation (HP:0001663) | 2.01867525 |
| 99 | Prolonged QT interval (HP:0001657) | 2.01551515 |
| 100 | Abnormal pancreas size (HP:0012094) | 1.99129201 |
| 101 | Fair hair (HP:0002286) | 1.98243129 |
| 102 | Ketosis (HP:0001946) | 1.97779633 |
| 103 | Decreased circulating renin level (HP:0003351) | 1.97045332 |
| 104 | Polyuria (HP:0000103) | 1.97042858 |
| 105 | Abnormal urine output (HP:0012590) | 1.96212187 |
| 106 | Hyperthyroidism (HP:0000836) | 1.95371211 |
| 107 | Ankyloglossia (HP:0010296) | 1.94399333 |
| 108 | Hyperaldosteronism (HP:0000859) | 1.93331048 |
| 109 | Akinesia (HP:0002304) | 1.91699805 |
| 110 | Hypokalemia (HP:0002900) | 1.90734577 |
| 111 | Abnormality of renal excretion (HP:0011036) | 1.90700834 |
| 112 | Lower limb muscle weakness (HP:0007340) | 1.89064569 |
| 113 | Neuroendocrine neoplasm (HP:0100634) | 1.88890498 |
| 114 | Agitation (HP:0000713) | 1.88031668 |
| 115 | Hypokalemic alkalosis (HP:0001949) | 1.87828510 |
| 116 | Generalized hypopigmentation of hair (HP:0011358) | 1.87778144 |
| 117 | Bundle branch block (HP:0011710) | 1.87519356 |
| 118 | Abnormality of salivation (HP:0100755) | 1.87452989 |
| 119 | Incomplete penetrance (HP:0003829) | 1.87207067 |
| 120 | Psychosis (HP:0000709) | 1.85225335 |
| 121 | Hepatoblastoma (HP:0002884) | 1.85126805 |
| 122 | Diminished movement (HP:0002374) | 1.85085271 |
| 123 | Hypoventilation (HP:0002791) | 1.83655471 |
| 124 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.83638254 |
| 125 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.83638254 |
| 126 | Hyperphosphatemia (HP:0002905) | 1.81969904 |
| 127 | Abnormality of vitamin B metabolism (HP:0004340) | 1.81879927 |
| 128 | Megalencephaly (HP:0001355) | 1.81803667 |
| 129 | Neuronal loss in central nervous system (HP:0002529) | 1.81295418 |
| 130 | Enlarged penis (HP:0000040) | 1.80667049 |
| 131 | Hypokinesia (HP:0002375) | 1.79931223 |
| 132 | Failure to thrive in infancy (HP:0001531) | 1.77869838 |
| 133 | Abnormal EKG (HP:0003115) | 1.77496385 |
| 134 | Thickened helices (HP:0000391) | 1.76271970 |
| 135 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.75592883 |
| 136 | Abnormality of saccadic eye movements (HP:0000570) | 1.73384160 |
| 137 | Gait imbalance (HP:0002141) | 1.72550513 |
| 138 | Specific learning disability (HP:0001328) | 1.72256353 |
| 139 | Rigidity (HP:0002063) | 1.72029328 |
| 140 | Abnormality of the corticospinal tract (HP:0002492) | 1.71629579 |
| 141 | Abnormality of the renal cortex (HP:0011035) | 1.71236955 |
| 142 | Pointed chin (HP:0000307) | 1.70645128 |
| 143 | Abnormality of proline metabolism (HP:0010907) | 1.70228894 |
| 144 | Hydroxyprolinuria (HP:0003080) | 1.70228894 |
| 145 | Lower limb asymmetry (HP:0100559) | 1.69109504 |
| 146 | Lower limb amyotrophy (HP:0007210) | 1.66447948 |
| 147 | Obstructive sleep apnea (HP:0002870) | 1.65177274 |
| 148 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.63185541 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.74737671 |
| 2 | EPHA4 | 4.71586081 |
| 3 | FRK | 4.48624364 |
| 4 | MAP3K9 | 3.50513382 |
| 5 | MAP3K4 | 3.19051651 |
| 6 | CASK | 2.96666686 |
| 7 | MAP2K7 | 2.76306060 |
| 8 | MINK1 | 2.37811799 |
| 9 | DAPK2 | 2.34743212 |
| 10 | NTRK2 | 2.29053092 |
| 11 | MARK1 | 2.22188667 |
| 12 | MAP3K12 | 2.17424578 |
| 13 | MAP2K4 | 2.02189909 |
| 14 | KSR2 | 1.94445725 |
| 15 | NTRK1 | 1.91674633 |
| 16 | RIPK4 | 1.89720213 |
| 17 | PAK6 | 1.83763231 |
| 18 | CAMKK1 | 1.75616975 |
| 19 | PRKD3 | 1.73063385 |
| 20 | TNIK | 1.69144776 |
| 21 | ACVR1B | 1.62930121 |
| 22 | PNCK | 1.62769992 |
| 23 | DAPK1 | 1.57480167 |
| 24 | ARAF | 1.50940211 |
| 25 | KSR1 | 1.50520704 |
| 26 | CDK5 | 1.49860367 |
| 27 | PLK2 | 1.47490896 |
| 28 | CAMKK2 | 1.47250667 |
| 29 | FES | 1.46859177 |
| 30 | STK39 | 1.36657157 |
| 31 | GRK5 | 1.35009735 |
| 32 | MAP3K13 | 1.31130195 |
| 33 | SIK2 | 1.24093383 |
| 34 | PRKCG | 1.22756749 |
| 35 | STK38 | 1.20446758 |
| 36 | PRPF4B | 1.19828878 |
| 37 | CDK19 | 1.17352610 |
| 38 | MAP3K2 | 1.14110483 |
| 39 | AKT3 | 1.06551027 |
| 40 | CAMK2A | 1.05425871 |
| 41 | CSNK1G1 | 1.05391374 |
| 42 | MAPK13 | 1.04625667 |
| 43 | MAP4K2 | 1.03747997 |
| 44 | TYRO3 | 1.03718058 |
| 45 | BMPR1B | 1.01974347 |
| 46 | SGK2 | 0.98230946 |
| 47 | SGK494 | 0.98058580 |
| 48 | SGK223 | 0.98058580 |
| 49 | STK38L | 0.97767832 |
| 50 | CSNK1G3 | 0.96381037 |
| 51 | ERBB3 | 0.96072603 |
| 52 | TAOK3 | 0.95977853 |
| 53 | UHMK1 | 0.93843412 |
| 54 | PASK | 0.93709973 |
| 55 | CAMK1 | 0.93586379 |
| 56 | ADRBK2 | 0.92005613 |
| 57 | BMPR2 | 0.84692568 |
| 58 | MAP2K6 | 0.83046521 |
| 59 | CAMK2B | 0.83031997 |
| 60 | STK11 | 0.82314165 |
| 61 | MUSK | 0.82089067 |
| 62 | PRKCH | 0.81731367 |
| 63 | PIK3CA | 0.81615835 |
| 64 | RAF1 | 0.79793439 |
| 65 | SGK3 | 0.79212576 |
| 66 | CDK18 | 0.77783423 |
| 67 | CDK14 | 0.75488196 |
| 68 | CDK15 | 0.75485353 |
| 69 | SGK1 | 0.75107270 |
| 70 | OXSR1 | 0.74921573 |
| 71 | RET | 0.73440669 |
| 72 | PINK1 | 0.73409973 |
| 73 | CCNB1 | 0.73113286 |
| 74 | LATS2 | 0.72958282 |
| 75 | WNK4 | 0.72063555 |
| 76 | PRKCE | 0.71615621 |
| 77 | PTK2B | 0.71187237 |
| 78 | GRK1 | 0.69630105 |
| 79 | PRKG2 | 0.68453179 |
| 80 | TNK2 | 0.67668919 |
| 81 | PAK3 | 0.64445349 |
| 82 | TAOK1 | 0.63824471 |
| 83 | PHKG2 | 0.63677776 |
| 84 | PHKG1 | 0.63677776 |
| 85 | CDK11A | 0.63563696 |
| 86 | MAPKAPK5 | 0.61660765 |
| 87 | CAMK1G | 0.61403627 |
| 88 | MAP3K1 | 0.61012907 |
| 89 | PRKAA1 | 0.59221577 |
| 90 | PDK1 | 0.59167855 |
| 91 | FGFR3 | 0.58498769 |
| 92 | CSNK1G2 | 0.58213723 |
| 93 | EPHA3 | 0.57263127 |
| 94 | PDPK1 | 0.56932767 |
| 95 | NEK6 | 0.54671064 |
| 96 | ERBB4 | 0.54362273 |
| 97 | NME1 | 0.53934326 |
| 98 | FER | 0.53908238 |
| 99 | ROCK1 | 0.53028745 |
| 100 | CAMK2G | 0.52738099 |
| 101 | BRAF | 0.52353732 |
| 102 | DYRK1A | 0.52161420 |
| 103 | CAMK2D | 0.51715253 |
| 104 | RPS6KA3 | 0.50565239 |
| 105 | ALK | 0.50552259 |
| 106 | MARK2 | 0.49690550 |
| 107 | PRKG1 | 0.47993575 |
| 108 | WNK3 | 0.47854039 |
| 109 | TRPM7 | 0.46944238 |
| 110 | SCYL2 | 0.46579021 |
| 111 | LMTK2 | 0.46533761 |
| 112 | MST4 | 0.46170250 |
| 113 | MAP2K1 | 0.45958448 |
| 114 | PKN1 | 0.45486482 |
| 115 | PRKACA | 0.45473613 |
| 116 | PRKCA | 0.45369942 |
| 117 | FYN | 0.45049270 |
| 118 | CSNK1A1 | 0.44719561 |
| 119 | CSNK1D | 0.43969669 |
| 120 | PRKCZ | 0.41573787 |
| 121 | MAP3K6 | 0.41181413 |
| 122 | NLK | 0.40041452 |
| 123 | PDK3 | 0.39156459 |
| 124 | PDK4 | 0.39156459 |
| 125 | CAMK4 | 0.38975347 |
| 126 | ADRBK1 | 0.38452287 |
| 127 | CDC42BPA | 0.38163952 |
| 128 | MAPK10 | 0.37855651 |
| 129 | FGR | 0.37027216 |
| 130 | WNK1 | 0.36566636 |
| 131 | STK24 | 0.36289646 |
| 132 | HIPK2 | 0.36013081 |
| 133 | PRKCB | 0.35868307 |
| 134 | FGFR2 | 0.35622850 |
| 135 | IRAK2 | 0.34876094 |
| 136 | CSNK1A1L | 0.34487794 |
| 137 | MAP3K7 | 0.34142252 |
| 138 | INSRR | 0.34031446 |
| 139 | LIMK1 | 0.33817235 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.94056347 |
| 2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 3.41769824 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.41671402 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 3.01482798 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.80123426 |
| 6 | Olfactory transduction_Homo sapiens_hsa04740 | 2.78194412 |
| 7 | Morphine addiction_Homo sapiens_hsa05032 | 2.69536604 |
| 8 | Circadian entrainment_Homo sapiens_hsa04713 | 2.62661559 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.54725115 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.52567192 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.43074868 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.15256849 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 2.12418777 |
| 14 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.97095311 |
| 15 | Insulin secretion_Homo sapiens_hsa04911 | 1.94080433 |
| 16 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.92944379 |
| 17 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.86571615 |
| 18 | Taste transduction_Homo sapiens_hsa04742 | 1.81414410 |
| 19 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.78339363 |
| 20 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.78011150 |
| 21 | Cocaine addiction_Homo sapiens_hsa05030 | 1.76133904 |
| 22 | Long-term depression_Homo sapiens_hsa04730 | 1.76125291 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.72557777 |
| 24 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.71766260 |
| 25 | Renin secretion_Homo sapiens_hsa04924 | 1.69061459 |
| 26 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.63192931 |
| 27 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.59271695 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.59058262 |
| 29 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.41358044 |
| 30 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.39230739 |
| 31 | Mineral absorption_Homo sapiens_hsa04978 | 1.37633218 |
| 32 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.32282338 |
| 33 | Gap junction_Homo sapiens_hsa04540 | 1.29518283 |
| 34 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.29089802 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28353671 |
| 36 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.27508506 |
| 37 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.25425463 |
| 38 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.23671282 |
| 39 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.14742335 |
| 40 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.12772696 |
| 41 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.12256081 |
| 42 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.10793755 |
| 43 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.07683382 |
| 44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07216148 |
| 45 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.04150915 |
| 46 | Glioma_Homo sapiens_hsa05214 | 1.02747175 |
| 47 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.02150510 |
| 48 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.99657457 |
| 49 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.98689387 |
| 50 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.96560466 |
| 51 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.95635529 |
| 52 | Melanogenesis_Homo sapiens_hsa04916 | 0.94257463 |
| 53 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.94172023 |
| 54 | Axon guidance_Homo sapiens_hsa04360 | 0.91244208 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.90723789 |
| 56 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.85680147 |
| 57 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.85505735 |
| 58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.82917001 |
| 59 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.82042388 |
| 60 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.80319820 |
| 61 | Phototransduction_Homo sapiens_hsa04744 | 0.80022032 |
| 62 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.79383646 |
| 63 | ABC transporters_Homo sapiens_hsa02010 | 0.79256556 |
| 64 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.78447484 |
| 65 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.76368502 |
| 66 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.76161876 |
| 67 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.75362591 |
| 68 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.73901662 |
| 69 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.72405312 |
| 70 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.70478762 |
| 71 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.67729685 |
| 72 | Histidine metabolism_Homo sapiens_hsa00340 | 0.67634772 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.67607501 |
| 74 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.66139359 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.65822339 |
| 76 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.65702092 |
| 77 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.64830553 |
| 78 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.63330908 |
| 79 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.62815425 |
| 80 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.61527492 |
| 81 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.61138107 |
| 82 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.59550502 |
| 83 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.58227431 |
| 84 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.55887386 |
| 85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.55848223 |
| 86 | Alcoholism_Homo sapiens_hsa05034 | 0.55394156 |
| 87 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.53967793 |
| 88 | Protein export_Homo sapiens_hsa03060 | 0.53780219 |
| 89 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53775997 |
| 90 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.53736813 |
| 91 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.52973107 |
| 92 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.52662054 |
| 93 | Alzheimers disease_Homo sapiens_hsa05010 | 0.52645207 |
| 94 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52603570 |
| 95 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.52582817 |
| 96 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.49511223 |
| 97 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49197790 |
| 98 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.48111460 |
| 99 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.48110384 |
| 100 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.46956740 |
| 101 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.46904208 |
| 102 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.45096402 |
| 103 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.45074324 |
| 104 | Bile secretion_Homo sapiens_hsa04976 | 0.44930136 |
| 105 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.43611117 |
| 106 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.43600470 |
| 107 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.43333477 |
| 108 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.42326622 |
| 109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.41812416 |
| 110 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.41463541 |
| 111 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.40994605 |
| 112 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.40607495 |
| 113 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.40585105 |
| 114 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.40076306 |
| 115 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.39287132 |
| 116 | Circadian rhythm_Homo sapiens_hsa04710 | 0.38845779 |
| 117 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.38738199 |
| 118 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.38502032 |
| 119 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.38069556 |
| 120 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.37730365 |
| 121 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.37456774 |
| 122 | Prion diseases_Homo sapiens_hsa05020 | 0.36960429 |
| 123 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.36720166 |
| 124 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.35635683 |
| 125 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.35411700 |
| 126 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.35371573 |
| 127 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.35098025 |
| 128 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.34818812 |
| 129 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.34796175 |
| 130 | Endocytosis_Homo sapiens_hsa04144 | 0.34419809 |
| 131 | Parkinsons disease_Homo sapiens_hsa05012 | 0.34239976 |
| 132 | Peroxisome_Homo sapiens_hsa04146 | 0.33267183 |
| 133 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.33016674 |
| 134 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.32149675 |
| 135 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31319723 |
| 136 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.30133508 |
| 137 | Endometrial cancer_Homo sapiens_hsa05213 | 0.27929767 |
| 138 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.27708721 |

