SLC2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.80194101
2epoxygenase P450 pathway (GO:0019373)8.46469959
3omega-hydroxylase P450 pathway (GO:0097267)7.77533835
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.75509326
5L-phenylalanine catabolic process (GO:0006559)6.75509326
6L-phenylalanine metabolic process (GO:0006558)6.36835861
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.36835861
8glucuronate metabolic process (GO:0019585)6.31090551
9uronic acid metabolic process (GO:0006063)6.31090551
10fibrinolysis (GO:0042730)6.19768177
11ethanol oxidation (GO:0006069)6.15809431
12blood coagulation, intrinsic pathway (GO:0007597)5.83281107
13oxidative demethylation (GO:0070989)5.77393100
14aromatic amino acid family catabolic process (GO:0009074)5.69589757
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.20461540
16phenylpropanoid metabolic process (GO:0009698)5.19004464
17Golgi transport vesicle coating (GO:0048200)5.10260098
18COPI coating of Golgi vesicle (GO:0048205)5.10260098
19ethanol metabolic process (GO:0006067)4.97316377
20protein activation cascade (GO:0072376)4.84434882
21negative regulation of hemostasis (GO:1900047)4.78215077
22negative regulation of blood coagulation (GO:0030195)4.78215077
23tryptophan catabolic process (GO:0006569)4.73671051
24indole-containing compound catabolic process (GO:0042436)4.73671051
25indolalkylamine catabolic process (GO:0046218)4.73671051
26regulation of plasminogen activation (GO:0010755)4.73646469
27tryptophan metabolic process (GO:0006568)4.72940360
28high-density lipoprotein particle remodeling (GO:0034375)4.66455617
29glyoxylate metabolic process (GO:0046487)4.66149053
30hormone catabolic process (GO:0042447)4.65340324
31glycine metabolic process (GO:0006544)4.61194570
32bile acid biosynthetic process (GO:0006699)4.60051504
33intestinal cholesterol absorption (GO:0030299)4.59493931
34alpha-linolenic acid metabolic process (GO:0036109)4.59257111
35alkaloid metabolic process (GO:0009820)4.55558518
36kynurenine metabolic process (GO:0070189)4.54023843
37urea cycle (GO:0000050)4.53171025
38urea metabolic process (GO:0019627)4.53171025
39complement activation (GO:0006956)4.50498651
40complement activation, classical pathway (GO:0006958)4.46915377
41protein carboxylation (GO:0018214)4.45270570
42peptidyl-glutamic acid carboxylation (GO:0017187)4.45270570
43sulfur amino acid catabolic process (GO:0000098)4.37742342
44tyrosine metabolic process (GO:0006570)4.36800426
45negative regulation of coagulation (GO:0050819)4.36523840
46regulation of humoral immune response (GO:0002920)4.35313669
47acute-phase response (GO:0006953)4.31767652
48negative regulation of wound healing (GO:0061045)4.31685681
49negative regulation of protein activation cascade (GO:2000258)4.29427330
50cysteine metabolic process (GO:0006534)4.28591854
51reverse cholesterol transport (GO:0043691)4.27250168
52phospholipid efflux (GO:0033700)4.26996115
53acylglycerol homeostasis (GO:0055090)4.25620297
54triglyceride homeostasis (GO:0070328)4.25620297
55bile acid metabolic process (GO:0008206)4.22214180
56fat-soluble vitamin biosynthetic process (GO:0042362)4.21167476
57aromatic amino acid family metabolic process (GO:0009072)4.19959795
58arginine metabolic process (GO:0006525)4.19770877
59negative regulation of fibrinolysis (GO:0051918)4.18529735
60nitrogen cycle metabolic process (GO:0071941)4.17489012
61very-low-density lipoprotein particle assembly (GO:0034379)4.15088495
62COPII vesicle coating (GO:0048208)4.14967135
63regulation of cholesterol esterification (GO:0010872)4.14916991
64S-adenosylmethionine metabolic process (GO:0046500)4.14731750
65regulation of fibrinolysis (GO:0051917)4.12551797
66homocysteine metabolic process (GO:0050667)4.07818916
67lysine metabolic process (GO:0006553)4.07362025
68lysine catabolic process (GO:0006554)4.07362025
69* endocrine pancreas development (GO:0031018)4.03619409
70positive regulation of blood coagulation (GO:0030194)4.00955348
71positive regulation of hemostasis (GO:1900048)4.00955348
72complement activation, alternative pathway (GO:0006957)3.98181531
73protein-lipid complex remodeling (GO:0034368)3.97514567
74macromolecular complex remodeling (GO:0034367)3.97514567
75plasma lipoprotein particle remodeling (GO:0034369)3.97514567
76intestinal absorption (GO:0050892)3.96085621
77fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95270954
78heme transport (GO:0015886)3.95221883
79bile acid and bile salt transport (GO:0015721)3.93306146
80regulation of triglyceride catabolic process (GO:0010896)3.87642437
81serine family amino acid catabolic process (GO:0009071)3.86978103
82regulation of protein activation cascade (GO:2000257)3.82948893
83drug transmembrane transport (GO:0006855)3.80596059
84cholesterol efflux (GO:0033344)3.79841852
85regulation of cholesterol homeostasis (GO:2000188)3.78807211
86indolalkylamine metabolic process (GO:0006586)3.77555771
87cytolysis (GO:0019835)3.75343527
88serine family amino acid metabolic process (GO:0009069)3.75019448
89daunorubicin metabolic process (GO:0044597)3.73081586
90polyketide metabolic process (GO:0030638)3.73081586
91doxorubicin metabolic process (GO:0044598)3.73081586
92alpha-amino acid catabolic process (GO:1901606)3.73015910
93drug catabolic process (GO:0042737)3.72528246
94positive regulation of coagulation (GO:0050820)3.71093193
95negative regulation of cholesterol transport (GO:0032375)3.69252346
96negative regulation of sterol transport (GO:0032372)3.69252346
97amino-acid betaine metabolic process (GO:0006577)3.68411445
98cellular ketone body metabolic process (GO:0046950)3.68239075
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.65723542
100coenzyme catabolic process (GO:0009109)3.61077463
101plasma lipoprotein particle assembly (GO:0034377)3.59077810
102plasma lipoprotein particle clearance (GO:0034381)3.58856648
103opsonization (GO:0008228)3.58811641
104positive regulation of lipid catabolic process (GO:0050996)3.58490168
105peptide hormone processing (GO:0016486)3.58396947
106lipoprotein metabolic process (GO:0042157)3.56608660
107xenobiotic metabolic process (GO:0006805)3.55403726
108killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.54948993
109disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.54948993
110negative regulation of complement activation (GO:0045916)3.54121193
111regulation of complement activation (GO:0030449)3.53583826
112cellular amino acid catabolic process (GO:0009063)3.49832424
113steroid catabolic process (GO:0006706)3.47778046
114maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47526137
115response to mercury ion (GO:0046689)3.45176791
116cellular modified amino acid catabolic process (GO:0042219)3.44899990
117imidazole-containing compound metabolic process (GO:0052803)3.44688711
118regulation of bile acid biosynthetic process (GO:0070857)3.39687268
119glutamate metabolic process (GO:0006536)3.35652199
120phospholipid homeostasis (GO:0055091)3.34191789
121cellular glucuronidation (GO:0052695)3.29066493
122cholesterol homeostasis (GO:0042632)3.28908280
123drug metabolic process (GO:0017144)3.27767179
1244-hydroxyproline metabolic process (GO:0019471)3.27250113
125positive regulation of lipoprotein lipase activity (GO:0051006)3.26328612
126positive regulation of triglyceride lipase activity (GO:0061365)3.26328612
127benzene-containing compound metabolic process (GO:0042537)3.25289132
128sterol homeostasis (GO:0055092)3.25120485
129positive regulation of glycolytic process (GO:0045821)3.23166740
130positive regulation of fatty acid biosynthetic process (GO:0045723)3.19417900
131carboxylic acid catabolic process (GO:0046395)3.16917592
132organic acid catabolic process (GO:0016054)3.16917592
133retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16913696
134ketone body metabolic process (GO:1902224)3.16664522
135cellular biogenic amine catabolic process (GO:0042402)3.16619161
136amine catabolic process (GO:0009310)3.16619161
137fatty acid beta-oxidation (GO:0006635)3.16580718
138fatty acid oxidation (GO:0019395)3.16564579
139plasma lipoprotein particle organization (GO:0071827)3.16508495
140short-chain fatty acid metabolic process (GO:0046459)3.15731533
141protein-lipid complex assembly (GO:0065005)3.15722906
142regulation of cholesterol biosynthetic process (GO:0045540)3.15071252
143low-density lipoprotein particle remodeling (GO:0034374)3.14174564
144flavonoid metabolic process (GO:0009812)3.13835501
145negative regulation of lipase activity (GO:0060192)3.12742954
146monocarboxylic acid catabolic process (GO:0072329)3.10271227
147urate metabolic process (GO:0046415)3.09994747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.91012955
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.44086597
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.29149964
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.99223152
5* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.62236260
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.94936409
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45798035
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.40121318
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.63874224
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.41542216
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.27204695
12GATA1_22025678_ChIP-Seq_K562_Human3.20322852
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98644087
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76735947
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.76570871
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.73944274
17CLOCK_20551151_ChIP-Seq_293T_Human1.71867135
18* FOXA2_19822575_ChIP-Seq_HepG2_Human1.71057454
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70497418
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61477846
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.50272062
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49843995
23HTT_18923047_ChIP-ChIP_STHdh_Human1.48945970
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.42765039
25* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36753474
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.29261320
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27638312
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25055770
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23826171
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19269930
31FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17457260
32* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16964013
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15874788
34* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15864831
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11195499
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08724018
37GATA4_25053715_ChIP-Seq_YYC3_Human1.08161217
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05390473
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.02129642
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01073847
41ESR1_21235772_ChIP-Seq_MCF-7_Human0.95872004
42NFE2_27457419_Chip-Seq_LIVER_Mouse0.94892386
43TCF4_18268006_ChIP-ChIP_LS174T_Human0.93500546
44IRF8_22096565_ChIP-ChIP_GC-B_Human0.93235022
45GATA1_19941826_ChIP-Seq_K562_Human0.93027681
46HNFA_21074721_ChIP-Seq_CACO-2_Human0.92813426
47* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91846289
48FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91197042
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.89949095
50CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88127308
51RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87281622
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85766211
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84665122
54PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.83124486
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82089698
56PHF8_20622853_ChIP-Seq_HELA_Human0.81491913
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81276565
58EZH2_27294783_Chip-Seq_NPCs_Mouse0.80660323
59RARA_24833708_ChIP-Seq_LIVER_Mouse0.79923648
60CEBPB_22108803_ChIP-Seq_LS180_Human0.79428918
61ERG_20517297_ChIP-Seq_VCAP_Human0.79342100
62TP53_18474530_ChIP-ChIP_U2OS_Human0.77548591
63NFYA_21822215_ChIP-Seq_K562_Human0.76826952
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76334811
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75791522
66AR_20517297_ChIP-Seq_VCAP_Human0.74570703
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74154129
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74154129
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73496753
70SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72803974
71SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70493150
72GATA6_21074721_ChIP-Seq_CACO-2_Human0.69635188
73NR3C1_23031785_ChIP-Seq_PC12_Mouse0.69591499
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69033866
75BCAT_22108803_ChIP-Seq_LS180_Human0.68305198
76SOX2_20726797_ChIP-Seq_SW620_Human0.68268888
77CBX2_22325352_ChIP-Seq_293T-Rex_Human0.67262348
78RARB_24833708_ChIP-Seq_LIVER_Mouse0.66634388
79GATA6_25053715_ChIP-Seq_YYC3_Human0.66153082
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66102171
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65599995
82PIAS1_25552417_ChIP-Seq_VCAP_Human0.64904286
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.64307791
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64084220
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63345403
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.63272537
87PCGF2_27294783_Chip-Seq_NPCs_Mouse0.63112097
88REST_19997604_ChIP-ChIP_NEURONS_Mouse0.62818866
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.62551620
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.62260772
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62195094
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61934900
93EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61642583
94* SOX2_21211035_ChIP-Seq_LN229_Human0.61564070
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61292084
96ETV1_20927104_ChIP-Seq_GIST48_Human0.60739916
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.60609245
98RUNX1_27457419_Chip-Seq_LIVER_Mouse0.60401543
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59362546
100OCT4_18555785_Chip-Seq_ESCs_Mouse0.59257665
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.59016597
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.58952646
103NFIB_24661679_ChIP-Seq_LUNG_Mouse0.58496266
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.57842440
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.57736391
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57223719
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.56958115
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56917342
109* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56781480
110GATA2_19941826_ChIP-Seq_K562_Human0.56643167
111CBP_21632823_ChIP-Seq_H3396_Human0.56580663
112PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.55946695
113CDX2_22108803_ChIP-Seq_LS180_Human0.55931061
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.55437454
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55389941
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.54812772
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.54235108
118ER_23166858_ChIP-Seq_MCF-7_Human0.54048892
119PU1_27457419_Chip-Seq_LIVER_Mouse0.52943374
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.52744116
121KLF4_18555785_Chip-Seq_ESCs_Mouse0.52276541
122LXR_22292898_ChIP-Seq_THP-1_Human0.52266849
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52232864
124NFYB_21822215_ChIP-Seq_K562_Human0.52170077
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52163278
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.51631492
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.51030298
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.50731958
129SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50239750
130ETV2_25802403_ChIP-Seq_MESCs_Mouse0.49531802
131STAT1_17558387_ChIP-Seq_HELA_Human0.48727936
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.48245251
133NCOR_22424771_ChIP-Seq_293T_Human0.47186085
134OCT4_20526341_ChIP-Seq_ESCs_Human0.46871454
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46498144
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.46374507
137MYC_19915707_ChIP-ChIP_AK7_Human0.45254172
138* TP63_23658742_ChIP-Seq_EP156T_Human0.44856642
139GATA3_26560356_Chip-Seq_TH1_Human0.44021636
140P53_21459846_ChIP-Seq_SAOS-2_Human0.43865029
141LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.43214104
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.42827102
143* FOXO3_23340844_ChIP-Seq_DLD1_Human0.41524541
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.41293174
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.41293174

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.22613985
2MP0005360_urolithiasis6.23040832
3MP0005365_abnormal_bile_salt5.44296449
4MP0005085_abnormal_gallbladder_physiolo5.33858639
5MP0003195_calcinosis4.23938606
6MP0008875_abnormal_xenobiotic_pharmacok4.09937534
7MP0003252_abnormal_bile_duct3.90545401
8MP0003806_abnormal_nucleotide_metabolis3.24449331
9MP0010329_abnormal_lipoprotein_level2.94069917
10MP0009840_abnormal_foam_cell2.87198367
11MP0001666_abnormal_nutrient_absorption2.76898684
12MP0004043_abnormal_pH_regulation2.60817398
13MP0005083_abnormal_biliary_tract2.51507264
14MP0002877_abnormal_melanocyte_morpholog2.45733132
15MP0005332_abnormal_amino_acid2.32828471
16MP0002693_abnormal_pancreas_physiology2.29075909
17MP0002138_abnormal_hepatobiliary_system2.27036095
18MP0003283_abnormal_digestive_organ2.26338885
19MP0009780_abnormal_chondrocyte_physiolo2.15620307
20MP0003868_abnormal_feces_composition2.11490233
21* MP0001944_abnormal_pancreas_morphology1.99640920
22* MP0002118_abnormal_lipid_homeostasis1.95059932
23MP0000609_abnormal_liver_physiology1.91824074
24MP0004019_abnormal_vitamin_homeostasis1.90768502
25MP0005220_abnormal_exocrine_pancreas1.90016395
26* MP0002078_abnormal_glucose_homeostasis1.80277464
27MP0009643_abnormal_urine_homeostasis1.77749847
28MP0002909_abnormal_adrenal_gland1.74506058
29MP0003191_abnormal_cellular_cholesterol1.70116591
30MP0005379_endocrine/exocrine_gland_phen1.61564067
31MP0000678_abnormal_parathyroid_gland1.57073505
32MP0005319_abnormal_enzyme/_coenzyme1.46148763
33MP0001764_abnormal_homeostasis1.44904406
34MP0002837_dystrophic_cardiac_calcinosis1.39296517
35MP0004264_abnormal_extraembryonic_tissu1.37864763
36MP0003183_abnormal_peptide_metabolism1.36060999
37MP0000013_abnormal_adipose_tissue1.30982904
38MP0005636_abnormal_mineral_homeostasis1.30393880
39MP0002928_abnormal_bile_duct1.27535957
40MP0002876_abnormal_thyroid_physiology1.22102763
41MP0010386_abnormal_urinary_bladder1.19766956
42MP0005584_abnormal_enzyme/coenzyme_acti1.10857128
43MP0009697_abnormal_copulation1.08286235
44MP0005646_abnormal_pituitary_gland1.06673177
45MP0003300_gastrointestinal_ulcer1.03422719
46* MP0003953_abnormal_hormone_level1.03319719
47MP0001765_abnormal_ion_homeostasis1.02677057
48MP0001756_abnormal_urination0.99640911
49* MP0009642_abnormal_blood_homeostasis0.99278711
50MP0000598_abnormal_liver_morphology0.97566323
51MP0005448_abnormal_energy_balance0.95657957
52MP0005408_hypopigmentation0.94651556
53* MP0005535_abnormal_body_temperature0.91317083
54MP0009053_abnormal_anal_canal0.89651651
55MP0005084_abnormal_gallbladder_morpholo0.89607747
56MP0000462_abnormal_digestive_system0.87336332
57MP0005670_abnormal_white_adipose0.86187884
58MP0001661_extended_life_span0.86037271
59MP0002132_abnormal_respiratory_system0.85510941
60MP0005334_abnormal_fat_pad0.83625611
61MP0005058_abnormal_lysosome_morphology0.81532386
62MP0000639_abnormal_adrenal_gland0.78208013
63MP0006036_abnormal_mitochondrial_physio0.77489438
64MP0002896_abnormal_bone_mineralization0.77163210
65MP0001915_intracranial_hemorrhage0.77043213
66MP0003186_abnormal_redox_activity0.73399071
67MP0000604_amyloidosis0.69828862
68MP0008961_abnormal_basal_metabolism0.69609390
69MP0003879_abnormal_hair_cell0.68807444
70MP0000613_abnormal_salivary_gland0.67635164
71MP0003172_abnormal_lysosome_physiology0.67405257
72MP0000230_abnormal_systemic_arterial0.67120983
73MP0003690_abnormal_glial_cell0.65800796
74MP0002971_abnormal_brown_adipose0.65781505
75MP0005451_abnormal_body_composition0.65419879
76MP0008469_abnormal_protein_level0.63605186
77MP0009763_increased_sensitivity_to0.63553576
78MP0009672_abnormal_birth_weight0.63308649
79MP0000003_abnormal_adipose_tissue0.61083398
80MP0000538_abnormal_urinary_bladder0.60135747
81MP0003638_abnormal_response/metabolism_0.58820501
82MP0003959_abnormal_lean_body0.58479215
83MP0005464_abnormal_platelet_physiology0.57481291
84MP0005376_homeostasis/metabolism_phenot0.56391325
85MP0003656_abnormal_erythrocyte_physiolo0.54859987
86MP0010368_abnormal_lymphatic_system0.54137611
87MP0005647_abnormal_sex_gland0.53940406
88MP0009765_abnormal_xenobiotic_induced0.53652110
89MP0003011_delayed_dark_adaptation0.53501426
90MP0002254_reproductive_system_inflammat0.53058803
91MP0005266_abnormal_metabolism0.52170208
92MP0005248_abnormal_Harderian_gland0.52012251
93MP0008872_abnormal_physiological_respon0.51984418
94MP0005187_abnormal_penis_morphology0.50345073
95MP0002168_other_aberrant_phenotype0.49194681
96MP0003329_amyloid_beta_deposits0.48280914
97MP0004782_abnormal_surfactant_physiolog0.47147136
98MP0000566_synostosis0.45961739
99MP0002136_abnormal_kidney_physiology0.45835449
100MP0000249_abnormal_blood_vessel0.45047902
101MP0005023_abnormal_wound_healing0.44557741
102MP0002282_abnormal_trachea_morphology0.44356612
103MP0004130_abnormal_muscle_cell0.43654068
104MP0001986_abnormal_taste_sensitivity0.42634332
105MP0005166_decreased_susceptibility_to0.42594042
106MP0008874_decreased_physiological_sensi0.42268834
107MP0009764_decreased_sensitivity_to0.41894088
108MP0009785_altered_susceptibility_to0.40935653
109MP0002249_abnormal_larynx_morphology0.40141734
110MP0005164_abnormal_response_to0.39405042
111MP0002970_abnormal_white_adipose0.39307156
112MP0003718_maternal_effect0.38097382
113MP0003705_abnormal_hypodermis_morpholog0.37959935
114MP0010234_abnormal_vibrissa_follicle0.37761465
115MP0005375_adipose_tissue_phenotype0.37578498
116MP0001270_distended_abdomen0.37234240
117MP0009115_abnormal_fat_cell0.36574087
118MP0002234_abnormal_pharynx_morphology0.36322316
119MP0005395_other_phenotype0.36161424
120MP0005409_darkened_coat_color0.34941404
121MP0005666_abnormal_adipose_tissue0.34612534
122MP0004883_abnormal_blood_vessel0.34398746
123MP0010155_abnormal_intestine_physiology0.33087377
124MP0001845_abnormal_inflammatory_respons0.29856295
125MP0002089_abnormal_postnatal_growth/wei0.24102674
126MP0003075_altered_response_to0.23626417
127MP0004272_abnormal_basement_membrane0.21576427
128MP0000467_abnormal_esophagus_morphology0.21081155
129MP0000920_abnormal_myelination0.19844665
130MP0003632_abnormal_nervous_system0.18691643
131MP0005197_abnormal_uvea_morphology0.17294351
132MP0001881_abnormal_mammary_gland0.16944648
133MP0002135_abnormal_kidney_morphology0.16809366
134MP0004147_increased_porphyrin_level0.16682625
135MP0001851_eye_inflammation0.16647562

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)6.75223453
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.65871279
3Hypoglycemic seizures (HP:0002173)6.32946344
4Hyperinsulinemic hypoglycemia (HP:0000825)6.28989455
5Systemic lupus erythematosus (HP:0002725)6.17216807
6Intrahepatic cholestasis (HP:0001406)6.01620977
7Symptomatic seizures (HP:0011145)5.47825583
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.41751748
9Prolonged partial thromboplastin time (HP:0003645)5.25389277
10Xanthomatosis (HP:0000991)5.15374034
11Hypobetalipoproteinemia (HP:0003563)5.04140994
12Deep venous thrombosis (HP:0002625)5.02953813
13Ketoacidosis (HP:0001993)4.71365806
14Conjugated hyperbilirubinemia (HP:0002908)4.60831341
15Ketosis (HP:0001946)4.59327111
16Abnormality of the intrinsic pathway (HP:0010989)4.49568140
17Abnormality of the common coagulation pathway (HP:0010990)4.24912640
18Hyperglycemia (HP:0003074)4.01517204
19Recurrent gram-negative bacterial infections (HP:0005420)3.94739128
20Late onset (HP:0003584)3.82434923
21Nephritis (HP:0000123)3.82080999
22Hyperlipoproteinemia (HP:0010980)3.80507554
23Epidermoid cyst (HP:0200040)3.69998232
24Hypolipoproteinemia (HP:0010981)3.66142995
25Abnormality of the pancreatic islet cells (HP:0006476)3.65624206
26Abnormality of endocrine pancreas physiology (HP:0012093)3.65624206
27Fat malabsorption (HP:0002630)3.63676145
28Joint hemorrhage (HP:0005261)3.63045388
29Complement deficiency (HP:0004431)3.52175489
30Pancreatic islet-cell hyperplasia (HP:0004510)3.46364077
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39032569
32Hyperammonemia (HP:0001987)3.31967239
33Hyperglycinemia (HP:0002154)3.28942559
34Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.28080882
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.26740682
36Gout (HP:0001997)3.23485247
37Hyperglycinuria (HP:0003108)3.21804427
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.18908515
39Hyperbilirubinemia (HP:0002904)3.08900288
40Insulin-resistant diabetes mellitus (HP:0000831)3.05418529
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05291648
42Skin nodule (HP:0200036)3.01151660
43Gingival bleeding (HP:0000225)2.99937542
44Hypoalphalipoproteinemia (HP:0003233)2.99653182
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.99358243
46Abnormality of glycine metabolism (HP:0010895)2.97161300
47Abnormality of serine family amino acid metabolism (HP:0010894)2.97161300
48Abnormality of methionine metabolism (HP:0010901)2.89444135
49Vascular calcification (HP:0004934)2.86660868
50Hemorrhage of the eye (HP:0011885)2.81503163
51Abnormality of fatty-acid metabolism (HP:0004359)2.76002243
52Irritability (HP:0000737)2.66475397
53Hypercholesterolemia (HP:0003124)2.57736361
54Cardiovascular calcification (HP:0011915)2.53461970
55Abnormality of vitamin metabolism (HP:0100508)2.50654941
56Insulin resistance (HP:0000855)2.50083451
57Urinary glycosaminoglycan excretion (HP:0003541)2.48369045
58Mucopolysacchariduria (HP:0008155)2.48369045
59Abnormality of complement system (HP:0005339)2.46659562
60* Abnormality of purine metabolism (HP:0004352)2.46211571
61Purpura (HP:0000979)2.44972750
62Metabolic acidosis (HP:0001942)2.44455958
63* Abnormality of nucleobase metabolism (HP:0010932)2.43831966
64Thrombophlebitis (HP:0004418)2.43027242
65Abnormality of pyrimidine metabolism (HP:0004353)2.39289085
66Reduced antithrombin III activity (HP:0001976)2.39128880
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.37772730
68Dicarboxylic aciduria (HP:0003215)2.37772730
69Hepatocellular carcinoma (HP:0001402)2.36418135
70Acanthocytosis (HP:0001927)2.34067038
71Enlarged kidneys (HP:0000105)2.32299808
72Pulmonary embolism (HP:0002204)2.31270749
73Fair hair (HP:0002286)2.29193489
74Abnormality of polysaccharide metabolism (HP:0011012)2.29192742
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29192742
76Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29192742
77Alkalosis (HP:0001948)2.27041392
78Protuberant abdomen (HP:0001538)2.26701835
79Delayed CNS myelination (HP:0002188)2.26250841
80Acute hepatic failure (HP:0006554)2.25537456
81Pancreatitis (HP:0001733)2.22644320
82Steatorrhea (HP:0002570)2.21098615
83Abnormal gallbladder morphology (HP:0012437)2.21064487
84Abnormal pancreas size (HP:0012094)2.20811434
85Abnormal gallbladder physiology (HP:0012438)2.15534056
86Cholecystitis (HP:0001082)2.15534056
87Large for gestational age (HP:0001520)2.14837124
88Limb hypertonia (HP:0002509)2.12727068
89Poikilocytosis (HP:0004447)2.09279319
90Hypophosphatemic rickets (HP:0004912)2.06036672
91Abnormality of calcium-phosphate metabolism (HP:0100530)2.04305667
92Mitral stenosis (HP:0001718)2.00437987
93Cholelithiasis (HP:0001081)2.00199228
94Neonatal hypoglycemia (HP:0001998)1.99229668
95Abnormality of serum amino acid levels (HP:0003112)1.99202605
96Brushfield spots (HP:0001088)1.98955151
97Lethargy (HP:0001254)1.97943531
98Arthropathy (HP:0003040)1.97234500
99Death in childhood (HP:0003819)1.95949011
100Decreased circulating renin level (HP:0003351)1.93349119
101Dysostosis multiplex (HP:0000943)1.92880699
102Hypochromic microcytic anemia (HP:0004840)1.92296364
103Myocardial infarction (HP:0001658)1.92027672
104Hyperuricemia (HP:0002149)1.91665053
105Increased purine levels (HP:0004368)1.91665053
106Menorrhagia (HP:0000132)1.89825314
107Proximal tubulopathy (HP:0000114)1.89054193
108Retinal atrophy (HP:0001105)1.87640164
109Abnormality of the Achilles tendon (HP:0005109)1.87497040
110Malnutrition (HP:0004395)1.86582276
111* Abnormal enzyme/coenzyme activity (HP:0012379)1.85828123
112Rickets (HP:0002748)1.83230087
113Abnormality of iron homeostasis (HP:0011031)1.82904444
114Renal cortical cysts (HP:0000803)1.82250311
115Increased serum ferritin (HP:0003281)1.82174597
116Joint swelling (HP:0001386)1.81642029
117Potter facies (HP:0002009)1.79336312
118Facial shape deformation (HP:0011334)1.79336312
119Spontaneous abortion (HP:0005268)1.77806484
120Nephrolithiasis (HP:0000787)1.77348343
121Abnormality of the gallbladder (HP:0005264)1.77154190
122Glomerulonephritis (HP:0000099)1.76344742
123Hydroxyprolinuria (HP:0003080)1.75485204
124Abnormality of proline metabolism (HP:0010907)1.75485204
125* Generalized aminoaciduria (HP:0002909)1.75312311
126* Elevated alkaline phosphatase (HP:0003155)1.73570955
127Bifid scrotum (HP:0000048)1.70386740
128Abnormality of transition element cation homeostasis (HP:0011030)1.70015220
129Increased mean platelet volume (HP:0011877)1.69968387
130* Glycosuria (HP:0003076)1.67489693
131* Abnormality of urine glucose concentration (HP:0011016)1.67489693
132Gangrene (HP:0100758)1.63338078
133Epistaxis (HP:0000421)1.61856253
134Sensorimotor neuropathy (HP:0007141)1.59775894
135Widely patent fontanelles and sutures (HP:0004492)1.59650675
136Cerebral palsy (HP:0100021)1.57750308
137Generalized hypopigmentation of hair (HP:0011358)1.56344579
138Abnormal biliary tract physiology (HP:0012439)1.56303445
139Bile duct proliferation (HP:0001408)1.56303445
140Abnormal platelet volume (HP:0011876)1.52070081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.87856197
2PASK4.42535765
3TAOK34.08286405
4BCKDK3.97461593
5ERN13.58743605
6MAPK153.49039733
7FRK3.42572334
8ACVR1B3.23239506
9SIK12.68144710
10FLT32.58323919
11MAP3K22.42824398
12PIK3CA2.40682501
13FGFR42.36909546
14HIPK22.09953651
15IRAK31.76653712
16PTK61.64926161
17PRKD31.64573240
18PRPF4B1.49974291
19MAP3K121.48801306
20WNK41.31281506
21MAP3K11.27387087
22MET1.25484759
23PTK21.22960260
24TRIB31.22489986
25LATS11.20676674
26EPHA31.18722420
27ERBB41.17431930
28PDGFRA1.16312240
29AKT31.15265015
30NTRK11.13522656
31ICK1.12162932
32IRAK11.10296401
33DYRK1B1.09955792
34SCYL21.09420017
35MYLK1.07643216
36MST1R1.06855385
37JAK21.06079735
38EPHA41.05687000
39EPHA21.03778374
40PIK3CG1.02950907
41PDK20.99947016
42MAP3K30.96230067
43PDK10.94944170
44CDK60.87372051
45PRKCH0.86648238
46MAPK110.86606743
47PRKG10.86025310
48CDC42BPA0.82692178
49JAK10.79913543
50IRAK20.77916883
51PRKAA10.77673382
52CSF1R0.75377997
53CAMKK20.74238729
54PAK30.73892458
55WNK30.73537499
56BRSK20.73272966
57PKN20.73271073
58PRKAA20.72434685
59MAP2K20.71023456
60TGFBR20.67961179
61MAP2K40.67908211
62ITK0.66243740
63MAP3K100.66010249
64BLK0.64788036
65TYK20.63350563
66GSK3A0.63177496
67STK390.62046672
68KSR20.60069786
69PRKCB0.59385988
70RET0.58500759
71SGK10.57216754
72SRC0.55084016
73* PRKACG0.54302983
74SGK30.54162719
75PINK10.52010225
76SGK20.51135056
77MAP3K50.50507885
78EIF2AK30.50017264
79CSNK1D0.49483886
80RPS6KA30.49167979
81FGFR30.49022779
82PRKD20.48392345
83MAP3K60.48348460
84CSNK1E0.47921131
85IGF1R0.45377642
86EPHB10.44663367
87DAPK20.44322928
88BCR0.44119623
89SGK2230.43246318
90SGK4940.43246318
91NTRK30.42668112
92ABL20.42363386
93FGFR10.42063230
94CSK0.41866176
95FGFR20.41336805
96RIPK10.41101234
97MAP3K140.40119646
98NEK90.39536006
99PRKACB0.38271566
100GRK10.37966348
101CASK0.37937354
102MAP3K110.37113575
103PRKCE0.36380690
104MAP2K30.35241745
105STK38L0.35180009
106OXSR10.34969158
107PRKCZ0.34713523
108UHMK10.34599369
109BRAF0.33966022
110JAK30.33538375
111NLK0.32952454
112MTOR0.32805936
113LMTK20.31217544
114NUAK10.30936207
115KDR0.30914316
116FER0.30594052
117ERBB20.30268052
118GRK60.29957290
119PDPK10.29860193
120MAP2K10.29825659
121CHUK0.29460462
122PRKD10.28060682
123RPS6KB10.27344226
124CAMKK10.25103709
125MAP3K70.24421899
126ZAP700.23799921
127CAMK1D0.23544485
128PRKCG0.23537022
129* PRKCA0.23466167
130* PRKACA0.23322779
131CSNK1A10.22651927
132CAMK2G0.22274742
133PRKG20.21500077
134TBK10.21370976
135TIE10.21290245

Predicted pathways (KEGG)

RankGene SetZ-score
1* Maturity onset diabetes of the young_Homo sapiens_hsa049504.79962942
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.61507294
3Nitrogen metabolism_Homo sapiens_hsa009103.12424802
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94147778
5Tryptophan metabolism_Homo sapiens_hsa003802.91033122
6Sulfur metabolism_Homo sapiens_hsa009202.80466445
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46781379
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39806279
9Arginine biosynthesis_Homo sapiens_hsa002202.34911815
10Butanoate metabolism_Homo sapiens_hsa006502.34457283
11Fatty acid degradation_Homo sapiens_hsa000712.32746495
12Selenocompound metabolism_Homo sapiens_hsa004502.19944183
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10929754
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08516986
15Complement and coagulation cascades_Homo sapiens_hsa046102.06924007
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01335984
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.00670583
18Histidine metabolism_Homo sapiens_hsa003401.98920330
19Protein export_Homo sapiens_hsa030601.93373724
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86117445
21Peroxisome_Homo sapiens_hsa041461.82797677
22Phenylalanine metabolism_Homo sapiens_hsa003601.64737245
23Starch and sucrose metabolism_Homo sapiens_hsa005001.62951220
24Fatty acid metabolism_Homo sapiens_hsa012121.61586737
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59602865
26Folate biosynthesis_Homo sapiens_hsa007901.57256068
27ABC transporters_Homo sapiens_hsa020101.55653173
28Propanoate metabolism_Homo sapiens_hsa006401.55651128
29Fat digestion and absorption_Homo sapiens_hsa049751.52264810
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.50748634
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47307577
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46313347
33PPAR signaling pathway_Homo sapiens_hsa033201.45659509
34Bile secretion_Homo sapiens_hsa049761.43520512
35Chemical carcinogenesis_Homo sapiens_hsa052041.42684607
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41108228
37beta-Alanine metabolism_Homo sapiens_hsa004101.40407757
38Tyrosine metabolism_Homo sapiens_hsa003501.35451088
39Caffeine metabolism_Homo sapiens_hsa002321.33791685
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30181231
41Fatty acid elongation_Homo sapiens_hsa000621.29735852
42Retinol metabolism_Homo sapiens_hsa008301.27752399
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23633777
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19154407
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15556505
46Arachidonic acid metabolism_Homo sapiens_hsa005901.12996619
47Staphylococcus aureus infection_Homo sapiens_hsa051501.12113017
48Pyruvate metabolism_Homo sapiens_hsa006201.06588909
49Steroid biosynthesis_Homo sapiens_hsa001000.97975020
50Vitamin digestion and absorption_Homo sapiens_hsa049770.96905614
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96577212
52Lysine degradation_Homo sapiens_hsa003100.94964911
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92458160
54Arginine and proline metabolism_Homo sapiens_hsa003300.85442557
55Galactose metabolism_Homo sapiens_hsa000520.80276310
56* Insulin secretion_Homo sapiens_hsa049110.78556945
57Carbon metabolism_Homo sapiens_hsa012000.77806158
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.77220291
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74363758
60Biosynthesis of amino acids_Homo sapiens_hsa012300.71019891
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69641431
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67156978
63* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61512357
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61172482
65* Type II diabetes mellitus_Homo sapiens_hsa049300.59082860
66Glycerolipid metabolism_Homo sapiens_hsa005610.57477532
67Prion diseases_Homo sapiens_hsa050200.52958978
68* Insulin resistance_Homo sapiens_hsa049310.52863768
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50728091
70Sulfur relay system_Homo sapiens_hsa041220.49887939
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.44164473
72Metabolic pathways_Homo sapiens_hsa011000.43030924
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.43007922
74One carbon pool by folate_Homo sapiens_hsa006700.42827233
75N-Glycan biosynthesis_Homo sapiens_hsa005100.42172644
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42075693
77Fructose and mannose metabolism_Homo sapiens_hsa000510.40239087
78Type I diabetes mellitus_Homo sapiens_hsa049400.39712935
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39343530
80Linoleic acid metabolism_Homo sapiens_hsa005910.37695298
81Vitamin B6 metabolism_Homo sapiens_hsa007500.37546324
82* Glucagon signaling pathway_Homo sapiens_hsa049220.35650233
83Lysosome_Homo sapiens_hsa041420.34195483
84Regulation of autophagy_Homo sapiens_hsa041400.33743495
85Glutathione metabolism_Homo sapiens_hsa004800.31813806
86Pertussis_Homo sapiens_hsa051330.30608843
87Thyroid hormone synthesis_Homo sapiens_hsa049180.26103669
88Vibrio cholerae infection_Homo sapiens_hsa051100.25936153
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.25733328
90Pentose phosphate pathway_Homo sapiens_hsa000300.22888271
91Mineral absorption_Homo sapiens_hsa049780.22349757
92Cocaine addiction_Homo sapiens_hsa050300.20094176
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17668144
94Fatty acid biosynthesis_Homo sapiens_hsa000610.16436742
95Circadian rhythm_Homo sapiens_hsa047100.15730515
96Other glycan degradation_Homo sapiens_hsa005110.14982280
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.14532532
98AMPK signaling pathway_Homo sapiens_hsa041520.14002876
99Insulin signaling pathway_Homo sapiens_hsa049100.10600945
100Renin-angiotensin system_Homo sapiens_hsa046140.10087592
101Pancreatic secretion_Homo sapiens_hsa049720.06830824
102Systemic lupus erythematosus_Homo sapiens_hsa053220.06169596
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.05475889
104Ovarian steroidogenesis_Homo sapiens_hsa049130.00999233
105Protein digestion and absorption_Homo sapiens_hsa049740.00667223
106Serotonergic synapse_Homo sapiens_hsa047260.00655716
107Ether lipid metabolism_Homo sapiens_hsa00565-0.1303180
108African trypanosomiasis_Homo sapiens_hsa05143-0.1271082
109Amoebiasis_Homo sapiens_hsa05146-0.0606649
110Sphingolipid metabolism_Homo sapiens_hsa00600-0.0552297

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