ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of molecule of bacterial origin (GO:0032490)	5.40846629
2	positive regulation of gamma-delta T cell activation (GO:0046645)	5.14825003
3	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.78188050
4	microglial cell activation (GO:0001774)	4.31105431
5	positive regulation by symbiont of host defense response (GO:0052509)	4.15411264
6	modulation by symbiont of host defense response (GO:0052031)	4.15411264
7	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	4.15411264
8	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	4.15411264
9	positive regulation by organism of defense response of other organism involved in symbiotic interact	4.15411264
10	modulation by symbiont of host immune response (GO:0052553)	4.15411264
11	neutrophil mediated immunity (GO:0002446)	4.11014762
12	regulation of B cell receptor signaling pathway (GO:0050855)	4.07858111
13	negative regulation of cell killing (GO:0031342)	4.03769781
14	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	4.03769781
15	regulation of activation of Janus kinase activity (GO:0010533)	4.03252785
16	regulation of gamma-delta T cell activation (GO:0046643)	4.00784882
17	regulation of gamma-delta T cell differentiation (GO:0045586)	3.94771879
18	negative regulation of cAMP-mediated signaling (GO:0043951)	3.90553564
19	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.80342701
20	phospholipid homeostasis (GO:0055091)	3.78014354
21	cellular extravasation (GO:0045123)	3.75359378
22	neutrophil activation (GO:0042119)	3.75194623
23	myeloid leukocyte mediated immunity (GO:0002444)	3.72454701
24	dopamine transport (GO:0015872)	3.72343285
25	macrophage activation (GO:0042116)	3.66785746
26	regulation of interferon-beta biosynthetic process (GO:0045357)	3.59516246
27	cellular response to epinephrine stimulus (GO:0071872)	3.59429298
28	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.57719184
29	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.53407540
30	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.53407540
31	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.51697276
32	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	3.45785949
33	macrophage activation involved in immune response (GO:0002281)	3.44681333
34	regulation of chemokine-mediated signaling pathway (GO:0070099)	3.40134258
35	detection of external biotic stimulus (GO:0098581)	3.39040634
36	cellular response to catecholamine stimulus (GO:0071870)	3.36117923
37	cellular response to monoamine stimulus (GO:0071868)	3.36117923
38	positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)	3.26165739
39	hepatocyte apoptotic process (GO:0097284)	3.23836663
40	granulocyte activation (GO:0036230)	3.22088009
41	dendritic cell migration (GO:0036336)	3.21584069
42	response to interleukin-15 (GO:0070672)	3.18514680
43	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.18295929
44	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	3.14856473
45	negative regulation of interleukin-12 production (GO:0032695)	3.14404201
46	response to epinephrine (GO:0071871)	3.12133767
47	negative regulation of T-helper cell differentiation (GO:0045623)	2.99629513
48	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.99629513
49	dendritic cell chemotaxis (GO:0002407)	2.98654101
50	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.98017864
51	negative regulation of B cell mediated immunity (GO:0002713)	2.98017864
52	regulation of T cell chemotaxis (GO:0010819)	2.96344535
53	positive regulation of T cell chemotaxis (GO:0010820)	2.96344535
54	response to monoamine (GO:0071867)	2.94268171
55	response to catecholamine (GO:0071869)	2.94268171
56	regulation of memory T cell differentiation (GO:0043380)	2.88210313
57	negative regulation of lymphocyte mediated immunity (GO:0002707)	2.87450886
58	regulation of necroptotic process (GO:0060544)	2.87395976
59	catecholamine transport (GO:0051937)	2.86523023
60	activated T cell proliferation (GO:0050798)	2.85585848
61	negative T cell selection (GO:0043383)	2.84396249
62	detection of biotic stimulus (GO:0009595)	2.83984897
63	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	2.82365207
64	regulation of beta-amyloid formation (GO:1902003)	2.80630548
65	negative regulation of B cell proliferation (GO:0030889)	2.78523960
66	regulation of interleukin-12 biosynthetic process (GO:0045075)	2.76308107
67	macroautophagy (GO:0016236)	2.76133997
68	negative thymic T cell selection (GO:0045060)	2.73605145
69	regulation of interleukin-6 biosynthetic process (GO:0045408)	2.70243152
70	negative regulation of protein autophosphorylation (GO:0031953)	2.69715138
71	histone H3-K36 demethylation (GO:0070544)	2.69391064
72	iron ion import (GO:0097286)	2.68862922
73	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.68481714
74	positive T cell selection (GO:0043368)	2.67713361
75	negative regulation of adaptive immune response based on somatic recombination of immune receptors b	2.66918062
76	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.66619747
77	response to host immune response (GO:0052572)	2.66619747
78	cellular response to ethanol (GO:0071361)	2.65540895
79	positive regulation of granulocyte differentiation (GO:0030854)	2.64884443
80	peristalsis (GO:0030432)	2.64876446
81	interkinetic nuclear migration (GO:0022027)	2.64479791
82	cardiac muscle hypertrophy (GO:0003300)	2.64424631
83	T-helper 1 type immune response (GO:0042088)	2.62404615
84	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.62160085
85	import into cell (GO:0098657)	2.62067730
86	monoubiquitinated protein deubiquitination (GO:0035520)	2.61840550
87	negative regulation of complement activation (GO:0045916)	2.60706436
88	negative regulation of myotube differentiation (GO:0010832)	2.60505359
89	regulation of regulatory T cell differentiation (GO:0045589)	2.59797904
90	negative regulation of leukocyte mediated immunity (GO:0002704)	2.59494815
91	cellular response to interleukin-15 (GO:0071350)	2.59238853
92	detection of other organism (GO:0098543)	2.57138401
93	cytidine deamination (GO:0009972)	2.56014331
94	cytidine metabolic process (GO:0046087)	2.56014331
95	cytidine catabolic process (GO:0006216)	2.56014331
96	positive regulation of tolerance induction (GO:0002645)	2.55963094
97	establishment of protein localization to Golgi (GO:0072600)	2.55878811
98	production of molecular mediator involved in inflammatory response (GO:0002532)	2.54526774
99	regulation of lymphocyte chemotaxis (GO:1901623)	2.53495844
100	positive thymic T cell selection (GO:0045059)	2.53272381

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.61633786
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.34548886
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.27048997
4	SMAD_19615063_ChIP-ChIP_OVARY_Human	3.22015330
5	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.06654046
6	RUNX_20019798_ChIP-Seq_JUKART_Human	2.95324570
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.88167456
8	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.69669587
9	GATA1_22025678_ChIP-Seq_K562_Human	2.39816143
10	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.27282213
11	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.22938291
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14743435
13	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	2.08688469
14	SCL_19346495_ChIP-Seq_HPC-7_Human	2.06374302
15	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	2.06019099
16	IRF8_27001747_Chip-Seq_BMDM_Mouse	2.03770732
17	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.88002139
18	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.85600453
19	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.83432336
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.80775491
21	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.80503932
22	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.79522161
23	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.71360713
24	VDR_24787735_ChIP-Seq_THP-1_Human	1.62646222
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60085602
26	TP53_16413492_ChIP-PET_HCT116_Human	1.58583872
27	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.55695579
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.55329008
29	SPI1_23127762_ChIP-Seq_K562_Human	1.52991413
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52572516
31	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.47904595
32	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.46794535
33	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.41055253
34	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.40904467
35	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.40078316
36	MYB_26560356_Chip-Seq_TH2_Human	1.39066958
37	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.30174072
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.29765927
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.27609023
40	GATA3_27048872_Chip-Seq_THYMUS_Human	1.26924552
41	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26407376
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24687018
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24436087
44	MYB_26560356_Chip-Seq_TH1_Human	1.23421178
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22594145
46	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.20983341
47	GATA1_19941826_ChIP-Seq_K562_Human	1.20081603
48	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20038368
49	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.19702680
50	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19349030
51	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.18186709
52	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17335426
53	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.16965879
54	ER_23166858_ChIP-Seq_MCF-7_Human	1.16645086
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15901484
56	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11838031
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.11719852
58	STAT3_23295773_ChIP-Seq_U87_Human	1.11665790
59	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.09034427
60	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08002440
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.06203595
62	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.05605252
63	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05436376
64	GATA3_26560356_Chip-Seq_TH2_Human	1.04505597
65	GATA2_19941826_ChIP-Seq_K562_Human	1.04283787
66	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.03993218
67	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03629740
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.03374326
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03076827
70	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.02783339
71	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.02267827
72	PU_27001747_Chip-Seq_BMDM_Mouse	1.01179206
73	RXR_22108803_ChIP-Seq_LS180_Human	1.00837452
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00014930
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.99846889
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99789986
77	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.99396499
78	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.99346593
79	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99050384
80	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.98209582
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.96612783
82	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96479674
83	SMRT_27268052_Chip-Seq_Bcells_Human	0.96387512
84	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.95604424
85	TCF4_23295773_ChIP-Seq_U87_Human	0.95348336
86	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95139910
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.94708367
88	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.94131685
89	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.92494129
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.92239605
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.91771054
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.91771054
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91241902
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.91241902
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.89767924
96	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.89264268
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.89028293
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.88350805
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.87967760
100	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.87167999

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005451_abnormal_body_composition	5.08659206
2	MP0000569_abnormal_digit_pigmentation	4.43231829
3	MP0003724_increased_susceptibility_to	4.29614247
4	MP0003880_abnormal_central_pattern	3.67483938
5	MP0008260_abnormal_autophagy	3.61938204
6	MP0003646_muscle_fatigue	3.46080718
7	MP0002332_abnormal_exercise_endurance	2.76435292
8	MP0003221_abnormal_cardiomyocyte_apopto	2.64592610
9	MP0004381_abnormal_hair_follicle	2.55447831
10	MP0003303_peritoneal_inflammation	2.54292852
11	MP0001835_abnormal_antigen_presentation	2.16832083
12	MP0003656_abnormal_erythrocyte_physiolo	2.14450519
13	MP0003950_abnormal_plasma_membrane	2.13636502
14	MP0004484_altered_response_of	2.10985443
15	MP0004130_abnormal_muscle_cell	1.98493829
16	MP0003195_calcinosis	1.97101005
17	MP0001800_abnormal_humoral_immune	1.80198210
18	MP0000749_muscle_degeneration	1.71731642
19	MP0002419_abnormal_innate_immunity	1.70447482
20	MP0002277_abnormal_respiratory_mucosa	1.69802605
21	MP0003828_pulmonary_edema	1.69735047
22	MP0005174_abnormal_tail_pigmentation	1.67798836
23	MP0003763_abnormal_thymus_physiology	1.64384862
24	MP0008057_abnormal_DNA_replication	1.63824091
25	MP0003172_abnormal_lysosome_physiology	1.60328899
26	MP0004883_abnormal_blood_vessel	1.59691628
27	MP0000015_abnormal_ear_pigmentation	1.56804186
28	MP0004145_abnormal_muscle_electrophysio	1.53028318
29	MP0003300_gastrointestinal_ulcer	1.51214714
30	MP0002723_abnormal_immune_serum	1.50219325
31	MP0005671_abnormal_response_to	1.49934497
32	MP0003436_decreased_susceptibility_to	1.49722865
33	MP0002166_altered_tumor_susceptibility	1.43998289
34	MP0003787_abnormal_imprinting	1.42903210
35	MP0000685_abnormal_immune_system	1.41509418
36	MP0000465_gastrointestinal_hemorrhage	1.41336170
37	MP0002420_abnormal_adaptive_immunity	1.37815378
38	MP0001819_abnormal_immune_cell	1.34473823
39	MP0005167_abnormal_blood-brain_barrier	1.33951994
40	MP0003011_delayed_dark_adaptation	1.33614120
41	MP0008877_abnormal_DNA_methylation	1.32982701
42	MP0005025_abnormal_response_to	1.32329159
43	MP0005000_abnormal_immune_tolerance	1.30004658
44	MP0002452_abnormal_antigen_presenting	1.28874584
45	MP0009785_altered_susceptibility_to	1.28755370
46	MP0003045_fibrosis	1.28657616
47	MP0005075_abnormal_melanosome_morpholog	1.28579283
48	MP0003183_abnormal_peptide_metabolism	1.27688133
49	MP0003191_abnormal_cellular_cholesterol	1.24701713
50	MP0004036_abnormal_muscle_relaxation	1.24629216
51	MP0006082_CNS_inflammation	1.23781828
52	MP0004510_myositis	1.22160381
53	MP0001958_emphysema	1.21257042
54	MP0001790_abnormal_immune_system	1.17986455
55	MP0005387_immune_system_phenotype	1.17986455
56	MP0005164_abnormal_response_to	1.14581042
57	MP0002102_abnormal_ear_morphology	1.12243484
58	MP0000427_abnormal_hair_cycle	1.11596938
59	MP0002398_abnormal_bone_marrow	1.11570750
60	MP0005620_abnormal_muscle_contractility	1.10648332
61	MP0000716_abnormal_immune_system	1.09983411
62	MP0003690_abnormal_glial_cell	1.09926842
63	MP0002148_abnormal_hypersensitivity_rea	1.07535184
64	MP0006138_congestive_heart_failure	1.05545161
65	MP0002909_abnormal_adrenal_gland	0.99772520
66	MP0005266_abnormal_metabolism	0.97988739
67	MP0001545_abnormal_hematopoietic_system	0.97518521
68	MP0005397_hematopoietic_system_phenotyp	0.97518521
69	MP0006054_spinal_hemorrhage	0.96804497
70	MP0009764_decreased_sensitivity_to	0.96197758
71	MP0002405_respiratory_system_inflammati	0.95994483
72	MP0002722_abnormal_immune_system	0.93175797
73	MP0005464_abnormal_platelet_physiology	0.93167207
74	MP0000689_abnormal_spleen_morphology	0.92330538
75	MP0001533_abnormal_skeleton_physiology	0.91386506
76	MP0005376_homeostasis/metabolism_phenot	0.89425841
77	MP0002106_abnormal_muscle_physiology	0.88332923
78	MP0003866_abnormal_defecation	0.86838889
79	MP0000751_myopathy	0.85450427
80	MP0002006_tumorigenesis	0.85301110
81	MP0001845_abnormal_inflammatory_respons	0.84870149
82	MP0000703_abnormal_thymus_morphology	0.84785468
83	MP0002127_abnormal_cardiovascular_syste	0.83258489
84	MP0004947_skin_inflammation	0.80790138
85	MP0008004_abnormal_stomach_pH	0.77568865
86	MP0004808_abnormal_hematopoietic_stem	0.76624177
87	MP0002429_abnormal_blood_cell	0.76613471
88	MP0000371_diluted_coat_color	0.76079155
89	MP0002132_abnormal_respiratory_system	0.76012518
90	MP0002971_abnormal_brown_adipose	0.75456431
91	MP0005666_abnormal_adipose_tissue	0.74741498
92	MP0002009_preneoplasia	0.73166143
93	MP0004084_abnormal_cardiac_muscle	0.72514847
94	MP0000249_abnormal_blood_vessel	0.71631134
95	MP0002972_abnormal_cardiac_muscle	0.71202841
96	MP0002168_other_aberrant_phenotype	0.70174617
97	MP0005310_abnormal_salivary_gland	0.69626481
98	MP0003091_abnormal_cell_migration	0.68774651
99	MP0009763_increased_sensitivity_to	0.68740987
100	MP0005375_adipose_tissue_phenotype	0.68685096

Predicted human phenotypes

Rank	Gene Set	Z-score
1	T lymphocytopenia (HP:0005403)	5.17867048
2	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	5.12563760
3	Abnormality of T cell number (HP:0011839)	4.91431186
4	Recurrent bacterial skin infections (HP:0005406)	4.64876730
5	Retrobulbar optic neuritis (HP:0100654)	4.52005031
6	Optic neuritis (HP:0100653)	4.52005031
7	Orchitis (HP:0100796)	4.24857042
8	Recurrent abscess formation (HP:0002722)	4.17377092
9	Myositis (HP:0100614)	4.04157195
10	Difficulty running (HP:0009046)	4.02071823
11	Eczematoid dermatitis (HP:0000976)	3.82252648
12	Gastrointestinal infarctions (HP:0005244)	3.72701304
13	Nemaline bodies (HP:0003798)	3.69426556
14	Muscle fiber inclusion bodies (HP:0100299)	3.57813714
15	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.55522722
16	Fibular aplasia (HP:0002990)	3.52532578
17	Recurrent gram-negative bacterial infections (HP:0005420)	3.51719142
18	Peritonitis (HP:0002586)	3.38066868
19	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.32222186
20	Keratoconjunctivitis sicca (HP:0001097)	3.31982968
21	Gingivitis (HP:0000230)	3.27697626
22	Recurrent fungal infections (HP:0002841)	3.12953405
23	Postural instability (HP:0002172)	3.11436507
24	Exercise-induced myalgia (HP:0003738)	3.10928907
25	Keratoconjunctivitis (HP:0001096)	2.99921403
26	Spontaneous hematomas (HP:0007420)	2.94781924
27	Abnormal finger flexion creases (HP:0006143)	2.80923395
28	Oligodactyly (hands) (HP:0001180)	2.79243290
29	Muscle fiber splitting (HP:0003555)	2.79045901
30	Hypoplastic iliac wings (HP:0002866)	2.78411056
31	Recurrent skin infections (HP:0001581)	2.72595263
32	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.68753515
33	Hyperkalemia (HP:0002153)	2.67827600
34	Abnormality of T cells (HP:0002843)	2.59043814
35	Chest pain (HP:0100749)	2.56908201
36	Leukocytosis (HP:0001974)	2.56461865
37	Subacute progressive viral hepatitis (HP:0006572)	2.56279145
38	Gingival bleeding (HP:0000225)	2.56038550
39	Type 1 muscle fiber predominance (HP:0003803)	2.54078099
40	Adactyly (HP:0009776)	2.53337314
41	Facial diplegia (HP:0001349)	2.49306544
42	Increased connective tissue (HP:0009025)	2.48027248
43	Broad ribs (HP:0000885)	2.47463812
44	Abnormality of macrophages (HP:0004311)	2.44899569
45	Arterial thrombosis (HP:0004420)	2.44390398
46	Eosinophilia (HP:0001880)	2.39749150
47	Stomatitis (HP:0010280)	2.38951239
48	Hemiplegia (HP:0002301)	2.36747313
49	Recurrent cutaneous fungal infections (HP:0011370)	2.36344007
50	Chronic mucocutaneous candidiasis (HP:0002728)	2.36344007
51	Radial bowing (HP:0002986)	2.33400005
52	Hemoptysis (HP:0002105)	2.32914535
53	Hypoplastic pelvis (HP:0008839)	2.30544583
54	Recurrent bronchitis (HP:0002837)	2.29506348
55	Encephalitis (HP:0002383)	2.29121998
56	Recurrent viral infections (HP:0004429)	2.22163823
57	Hyporeflexia of lower limbs (HP:0002600)	2.21847752
58	Keratitis (HP:0000491)	2.21565953
59	Abnormality of eosinophils (HP:0001879)	2.20658099
60	Narrow palate (HP:0000189)	2.17925362
61	Autoimmune hemolytic anemia (HP:0001890)	2.15365529
62	Hypoplastic nipples (HP:0002557)	2.14043313
63	Increased CSF protein (HP:0002922)	2.13912515
64	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.12213473
65	Elevated erythrocyte sedimentation rate (HP:0003565)	2.10399086
66	Abnormality of the pubic bones (HP:0003172)	2.08030040
67	Myocardial infarction (HP:0001658)	2.04965768
68	Subaortic stenosis (HP:0001682)	2.03292935
69	Abnormality of the left ventricular outflow tract (HP:0011103)	2.03292935
70	Meningitis (HP:0001287)	1.97698335
71	EMG: myopathic abnormalities (HP:0003458)	1.96851924
72	Hematochezia (HP:0002573)	1.96506663
73	Split foot (HP:0001839)	1.95487302
74	Slow saccadic eye movements (HP:0000514)	1.94026796
75	Pelvic girdle muscle weakness (HP:0003749)	1.91987669
76	Foot dorsiflexor weakness (HP:0009027)	1.91235294
77	Papillary thyroid carcinoma (HP:0002895)	1.89366653
78	Thyroiditis (HP:0100646)	1.88616460
79	Urticaria (HP:0001025)	1.88105767
80	Neurodegeneration (HP:0002180)	1.87270134
81	Aortic aneurysm (HP:0004942)	1.86154005
82	Exercise-induced muscle cramps (HP:0003710)	1.85658318
83	Amyloidosis (HP:0011034)	1.85643194
84	Long clavicles (HP:0000890)	1.84383642
85	Conjunctival telangiectasia (HP:0000524)	1.83206184
86	Periodontitis (HP:0000704)	1.82852994
87	Acute hepatic failure (HP:0006554)	1.81706879
88	Anorexia (HP:0002039)	1.81695354
89	Pulmonary embolism (HP:0002204)	1.80963363
90	Episodic fever (HP:0001954)	1.80096211
91	Granulocytopenia (HP:0001913)	1.79221036
92	Abnormality of the endocardium (HP:0004306)	1.78624797
93	Muscle hypertrophy of the lower extremities (HP:0008968)	1.77009465
94	Skull defect (HP:0001362)	1.76692980
95	Increased variability in muscle fiber diameter (HP:0003557)	1.75608720
96	Calf muscle hypertrophy (HP:0008981)	1.74449585
97	Vasculitis (HP:0002633)	1.74251594
98	Segmental peripheral demyelination/remyelination (HP:0003481)	1.73762211
99	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.71798720
100	Neoplasm of the tracheobronchial system (HP:0100552)	1.71332519

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	3.25801670
2	BLK	3.04239338
3	RIPK4	2.58942243
4	TIE1	2.53393279
5	CSK	2.40416844
6	FRK	2.38146994
7	FES	2.21754607
8	PIK3CG	2.11269212
9	TNIK	2.06840624
10	IRAK4	2.05391778
11	IKBKE	2.03413170
12	AKT3	1.96254135
13	MAP3K7	1.92344959
14	TAOK3	1.92107654
15	GRK6	1.89022512
16	MAP2K3	1.86886251
17	DAPK2	1.83030645
18	PTK2B	1.75734756
19	MAP3K6	1.69696471
20	SGK2	1.69056742
21	IRAK1	1.68536209
22	TYK2	1.65970530
23	WNK1	1.64224450
24	EPHB1	1.63211186
25	FGR	1.61363955
26	MAP3K14	1.59197413
27	BMPR2	1.56429063
28	MAP3K13	1.52141007
29	NLK	1.46847828
30	PIM1	1.45673047
31	JAK3	1.40959686
32	TTN	1.38211041
33	EPHA3	1.35007662
34	TXK	1.28485478
35	JAK1	1.23698452
36	SGK3	1.20520370
37	MARK2	1.13981790
38	SYK	1.11523663
39	YES1	1.10418599
40	TRPM7	1.09534863
41	LATS1	1.07197083
42	FGFR3	1.06274651
43	PRKAA2	1.04457218
44	ERBB2	1.04133677
45	STK4	1.02773124
46	JAK2	0.99063627
47	MAP3K2	0.97983201
48	TEC	0.97925343
49	HCK	0.97426251
50	MAP3K11	0.96518607
51	TGFBR2	0.96391233
52	STK24	0.91760831
53	IRAK2	0.91697932
54	ZAP70	0.91553733
55	SGK223	0.90850192
56	SGK494	0.90850192
57	LCK	0.90586611
58	NEK9	0.89484127
59	CHUK	0.89178671
60	CAMK4	0.85285773
61	ACVR1B	0.85168418
62	IKBKB	0.82817031
63	GRK5	0.81835896
64	MAP4K1	0.80958889
65	CAMKK2	0.80923281
66	CAMK1D	0.79102477
67	MATK	0.78111432
68	BTK	0.74046259
69	BMPR1B	0.70262143
70	DMPK	0.70193657
71	LYN	0.68888371
72	MAP2K4	0.68675427
73	PHKG1	0.66352745
74	PHKG2	0.66352745
75	SGK1	0.65893657
76	MAP3K1	0.65083191
77	MARK3	0.62664998
78	STK11	0.61493615
79	MAPK12	0.61360313
80	ITK	0.60539483
81	TBK1	0.60513875
82	PDGFRB	0.60028668
83	CAMK1	0.59234267
84	PINK1	0.54344944
85	KIT	0.51601818
86	MAP3K3	0.51299106
87	ADRBK1	0.50596246
88	CAMK1G	0.47954649
89	KSR1	0.47456885
90	PRKCQ	0.47356589
91	STK38	0.46737278
92	EGFR	0.44164176
93	RPS6KB1	0.44136942
94	GRK1	0.44072542
95	PLK2	0.42545586
96	TAOK1	0.42527183
97	PRKCZ	0.41970796
98	PAK3	0.40931284
99	RAF1	0.40852822
100	FER	0.40198995

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Osteoclast differentiation_Homo sapiens_hsa04380	2.26481858
2	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	2.13065683
3	Leishmaniasis_Homo sapiens_hsa05140	1.98916770
4	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.94015009
5	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.88746198
6	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.76098051
7	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.74612430
8	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.73671094
9	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.70608339
10	Tuberculosis_Homo sapiens_hsa05152	1.69206277
11	Measles_Homo sapiens_hsa05162	1.69181840
12	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.66899712
13	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.65725700
14	Non-small cell lung cancer_Homo sapiens_hsa05223	1.62836539
15	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.58773713
16	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.55677504
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.51513319
18	FoxO signaling pathway_Homo sapiens_hsa04068	1.48087690
19	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.46634468
20	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.39798675
21	Malaria_Homo sapiens_hsa05144	1.39615793
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.36728620
23	TNF signaling pathway_Homo sapiens_hsa04668	1.35668491
24	Chemokine signaling pathway_Homo sapiens_hsa04062	1.33354830
25	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.33289284
26	Legionellosis_Homo sapiens_hsa05134	1.33204534
27	Platelet activation_Homo sapiens_hsa04611	1.31811371
28	Insulin resistance_Homo sapiens_hsa04931	1.22383259
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.21112785
30	Acute myeloid leukemia_Homo sapiens_hsa05221	1.19612863
31	Notch signaling pathway_Homo sapiens_hsa04330	1.18906379
32	ABC transporters_Homo sapiens_hsa02010	1.15347968
33	Pancreatic cancer_Homo sapiens_hsa05212	1.12185084
34	Hepatitis C_Homo sapiens_hsa05160	1.11894542
35	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08954233
36	VEGF signaling pathway_Homo sapiens_hsa04370	1.05963621
37	Primary immunodeficiency_Homo sapiens_hsa05340	1.05170465
38	Renal cell carcinoma_Homo sapiens_hsa05211	1.03555258
39	Influenza A_Homo sapiens_hsa05164	1.02594251
40	mTOR signaling pathway_Homo sapiens_hsa04150	1.01978626
41	Regulation of autophagy_Homo sapiens_hsa04140	1.01444147
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00852629
43	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.99344449
44	Toxoplasmosis_Homo sapiens_hsa05145	0.97221350
45	Hepatitis B_Homo sapiens_hsa05161	0.96139105
46	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.95968456
47	Prolactin signaling pathway_Homo sapiens_hsa04917	0.93856775
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.93322263
49	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.93019860
50	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.90292333
51	Circadian rhythm_Homo sapiens_hsa04710	0.87580116
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85996267
53	Endometrial cancer_Homo sapiens_hsa05213	0.85882399
54	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.85655911
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.85508727
56	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.85414367
57	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.85187639
58	Graft-versus-host disease_Homo sapiens_hsa05332	0.84640402
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84613205
60	Type II diabetes mellitus_Homo sapiens_hsa04930	0.84422625
61	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.83427550
62	Apoptosis_Homo sapiens_hsa04210	0.83384445
63	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.80091771
64	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.79696430
65	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.77583707
66	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.75818260
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.75519864
68	Complement and coagulation cascades_Homo sapiens_hsa04610	0.73909084
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73255409
70	Insulin signaling pathway_Homo sapiens_hsa04910	0.72847032
71	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.70288084
72	Prostate cancer_Homo sapiens_hsa05215	0.69760239
73	Glioma_Homo sapiens_hsa05214	0.67923295
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.67840311
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.67613663
76	GnRH signaling pathway_Homo sapiens_hsa04912	0.65601728
77	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61648982
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.61123553
79	MAPK signaling pathway_Homo sapiens_hsa04010	0.60540028
80	Allograft rejection_Homo sapiens_hsa05330	0.59960611
81	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.58812665
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.58705451
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.57843737
84	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.57350958
85	Renin secretion_Homo sapiens_hsa04924	0.57086170
86	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.55901812
87	ErbB signaling pathway_Homo sapiens_hsa04012	0.55764312
88	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.54345940
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.52010483
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.51664828
91	Choline metabolism in cancer_Homo sapiens_hsa05231	0.51493553
92	Cholinergic synapse_Homo sapiens_hsa04725	0.51433385
93	Herpes simplex infection_Homo sapiens_hsa05168	0.50661259
94	Proteoglycans in cancer_Homo sapiens_hsa05205	0.50387190
95	Axon guidance_Homo sapiens_hsa04360	0.49490133
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.49327738
97	Ras signaling pathway_Homo sapiens_hsa04014	0.49201821
98	AMPK signaling pathway_Homo sapiens_hsa04152	0.48429374
99	Amoebiasis_Homo sapiens_hsa05146	0.47554755
100	MicroRNAs in cancer_Homo sapiens_hsa05206	0.46938830

SLC2A3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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