SLC2A3P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.82899559
2cellular response to ethanol (GO:0071361)5.52660103
3nuclear pore organization (GO:0006999)5.37295619
4monoubiquitinated protein deubiquitination (GO:0035520)5.36910384
5histone mRNA catabolic process (GO:0071044)4.69322527
6regulation of necroptotic process (GO:0060544)4.62925189
7replicative senescence (GO:0090399)4.60104657
8pore complex assembly (GO:0046931)4.53496197
9phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.38213535
10regulation of establishment of cell polarity (GO:2000114)4.21333509
11dosage compensation (GO:0007549)4.21135739
12protein K48-linked deubiquitination (GO:0071108)4.19652699
13hepatocyte apoptotic process (GO:0097284)4.14509833
14positive regulation of developmental pigmentation (GO:0048087)4.14429487
15protein K11-linked deubiquitination (GO:0035871)4.12490536
16regulation of establishment or maintenance of cell polarity (GO:0032878)4.10277649
17embryonic process involved in female pregnancy (GO:0060136)3.78998418
18histone H3-K36 demethylation (GO:0070544)3.77219633
19negative regulation of DNA repair (GO:0045738)3.74523770
20histone-serine phosphorylation (GO:0035404)3.74221074
21iron ion import (GO:0097286)3.71278991
22endothelial cell morphogenesis (GO:0001886)3.63344743
23regulation of centriole replication (GO:0046599)3.63085446
24chondrocyte proliferation (GO:0035988)3.56487337
25regulation of pigment cell differentiation (GO:0050932)3.53464132
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52680785
27fibroblast migration (GO:0010761)3.52169965
28definitive hemopoiesis (GO:0060216)3.49253147
29anterior/posterior axis specification, embryo (GO:0008595)3.49074803
30regulation of mitotic spindle checkpoint (GO:1903504)3.37197622
31regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.37197622
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36238077
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.36238077
34cytoplasmic mRNA processing body assembly (GO:0033962)3.34623165
35pericardium development (GO:0060039)3.34247429
36regulation of hippo signaling (GO:0035330)3.33472393
37UDP-N-acetylglucosamine metabolic process (GO:0006047)3.31076241
38meiotic chromosome segregation (GO:0045132)3.29879213
39regulation of centrosome duplication (GO:0010824)3.29622714
40protein prenylation (GO:0018342)3.28661705
41prenylation (GO:0097354)3.28661705
42positive regulation of gamma-delta T cell activation (GO:0046645)3.16384822
43establishment of protein localization to Golgi (GO:0072600)3.16135844
44SMAD protein complex assembly (GO:0007183)3.12385434
45positive regulation of protein import into nucleus, translocation (GO:0033160)3.11906123
46histone phosphorylation (GO:0016572)3.11629524
47striated muscle atrophy (GO:0014891)3.09614511
48I-kappaB phosphorylation (GO:0007252)3.04104996
49skeletal muscle adaptation (GO:0043501)3.03536602
50detection of molecule of bacterial origin (GO:0032490)2.99645029
51rRNA catabolic process (GO:0016075)2.97770566
52mitotic sister chromatid cohesion (GO:0007064)2.94576394
53negative regulation of B cell proliferation (GO:0030889)2.93187524
54protein K63-linked deubiquitination (GO:0070536)2.91360358
55negative regulation of necroptotic process (GO:0060546)2.84158698
56B cell receptor signaling pathway (GO:0050853)2.79869414
57positive regulation of SMAD protein import into nucleus (GO:0060391)2.79187255
58regulation of RNA export from nucleus (GO:0046831)2.75613357
59corticosteroid receptor signaling pathway (GO:0031958)2.74224832
60regulation of centrosome cycle (GO:0046605)2.73168009
61negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.73048540
62protein targeting to vacuole (GO:0006623)2.71829406
63protein targeting to lysosome (GO:0006622)2.71829406
64establishment of protein localization to vacuole (GO:0072666)2.71829406
65import into cell (GO:0098657)2.71492218
66positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.70912095
67protein targeting to Golgi (GO:0000042)2.66685703
68neural tube formation (GO:0001841)2.64215056
69regulation of DNA damage checkpoint (GO:2000001)2.62666988
70necroptotic process (GO:0070266)2.62641319
71snRNA transcription (GO:0009301)2.61794159
72DNA duplex unwinding (GO:0032508)2.57736350
73signal peptide processing (GO:0006465)2.57344954
74regulation of skeletal muscle contraction (GO:0014819)2.56040005
75microtubule anchoring (GO:0034453)2.54967304
76positive regulation of cell cycle checkpoint (GO:1901978)2.54690902
77negative regulation of cell cycle G2/M phase transition (GO:1902750)2.54580158
78DNA geometric change (GO:0032392)2.52979840
79regulation of B cell receptor signaling pathway (GO:0050855)2.52379690
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50786948
81regulation of necrotic cell death (GO:0010939)2.50416648
82microglial cell activation (GO:0001774)2.50125209
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.48965610
84positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.48319219
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.47214807
86regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.46578174
87regulation of NIK/NF-kappaB signaling (GO:1901222)2.45316600
88negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.44875465
89DNA damage induced protein phosphorylation (GO:0006975)2.43907848
90peptidyl-threonine dephosphorylation (GO:0035970)2.43907089
91regulation of gamma-delta T cell differentiation (GO:0045586)2.43769680
92centrosome duplication (GO:0051298)2.42950938
93interkinetic nuclear migration (GO:0022027)2.41335200
94spleen development (GO:0048536)2.40704990
95programmed necrotic cell death (GO:0097300)2.39578345
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.39519248
97necrotic cell death (GO:0070265)2.39359030
98DNA replication checkpoint (GO:0000076)2.38769823
99regulation of cardiac muscle cell contraction (GO:0086004)2.38240032
100NLS-bearing protein import into nucleus (GO:0006607)2.37852266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.70011348
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.67906094
3E2F7_22180533_ChIP-Seq_HELA_Human4.25119828
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.63000793
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.59373045
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.12537332
7GATA1_22025678_ChIP-Seq_K562_Human3.06396016
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96590386
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69793902
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.57352284
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.42181073
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.42056955
13TP53_16413492_ChIP-PET_HCT116_Human2.24255962
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13796483
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11733647
16TAF15_26573619_Chip-Seq_HEK293_Human2.01328001
17EWS_26573619_Chip-Seq_HEK293_Human2.00682429
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89877855
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88198808
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70708123
21FUS_26573619_Chip-Seq_HEK293_Human1.66829815
22E2F1_21310950_ChIP-Seq_MCF-7_Human1.66507964
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64861676
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63984499
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63673655
26SCL_19346495_ChIP-Seq_HPC-7_Human1.55693917
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52677607
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.51326285
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50331684
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.49760011
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46714606
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46103562
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45346792
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44297215
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43850848
36FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41453741
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38025970
38ER_23166858_ChIP-Seq_MCF-7_Human1.37931498
39AR_21572438_ChIP-Seq_LNCaP_Human1.37303244
40BRD4_25478319_ChIP-Seq_HGPS_Human1.35895115
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.35184088
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30957546
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29308229
44AHR_22903824_ChIP-Seq_MCF-7_Human1.29189618
45STAT3_23295773_ChIP-Seq_U87_Human1.28480537
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28276254
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25922763
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.24468972
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24248941
50P300_19829295_ChIP-Seq_ESCs_Human1.23930184
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22408221
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22408221
53SALL4_22934838_ChIP-ChIP_CD34+_Human1.20559715
54ELK1_19687146_ChIP-ChIP_HELA_Human1.20276192
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19985490
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19247659
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14414472
58MYB_26560356_Chip-Seq_TH1_Human1.14364027
59MYB_26560356_Chip-Seq_TH2_Human1.14158807
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13275042
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12794520
62BCAT_22108803_ChIP-Seq_LS180_Human1.12283639
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11887090
64RXR_22108803_ChIP-Seq_LS180_Human1.10888118
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10547638
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08602553
67VDR_23849224_ChIP-Seq_CD4+_Human1.07730252
68CDX2_22108803_ChIP-Seq_LS180_Human1.06577773
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.06558668
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05327376
71RUNX_20019798_ChIP-Seq_JUKART_Human1.03063850
72PU_27001747_Chip-Seq_BMDM_Mouse1.02987663
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02748457
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.02159293
75FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02059665
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99859998
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99627736
78ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99249577
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98633174
80CBP_20019798_ChIP-Seq_JUKART_Human0.98160125
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98160125
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.96328336
83IRF8_27001747_Chip-Seq_BMDM_Mouse0.95578507
84FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95552530
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95336702
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95301396
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95184499
88CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94264072
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94197177
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94197177
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94091530
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91836159
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.90236625
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89888923
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89721453
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.89139282
97FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87560812
98TCF4_23295773_ChIP-Seq_U87_Human0.87121399
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.86390784
100SMAD4_21799915_ChIP-Seq_A2780_Human0.85955090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.78510956
2MP0008057_abnormal_DNA_replication5.17216403
3MP0005083_abnormal_biliary_tract3.52519301
4MP0002009_preneoplasia3.50233417
5MP0003890_abnormal_embryonic-extraembry2.87451086
6MP0002396_abnormal_hematopoietic_system2.60957561
7MP0003828_pulmonary_edema2.26064591
8MP0003646_muscle_fatigue2.23918054
9MP0010094_abnormal_chromosome_stability2.19793504
10MP0002166_altered_tumor_susceptibility2.18834326
11MP0005174_abnormal_tail_pigmentation2.12153220
12MP0004381_abnormal_hair_follicle2.10741788
13MP0000015_abnormal_ear_pigmentation2.08776580
14MP0004808_abnormal_hematopoietic_stem2.08404746
15MP0006054_spinal_hemorrhage2.05483425
16MP0003763_abnormal_thymus_physiology1.95982005
17MP0002332_abnormal_exercise_endurance1.95373931
18MP0000427_abnormal_hair_cycle1.91580684
19MP0003221_abnormal_cardiomyocyte_apopto1.86467794
20MP0001661_extended_life_span1.77768766
21MP0010352_gastrointestinal_tract_polyps1.75637806
22MP0001879_abnormal_lymphatic_vessel1.65537567
23MP0003787_abnormal_imprinting1.65129457
24MP0004233_abnormal_muscle_weight1.62705380
25MP0003111_abnormal_nucleus_morphology1.54619692
26MP0002006_tumorigenesis1.49666419
27MP0003195_calcinosis1.48676762
28MP0003077_abnormal_cell_cycle1.47742555
29MP0010368_abnormal_lymphatic_system1.47717959
30MP0000383_abnormal_hair_follicle1.44994418
31MP0004130_abnormal_muscle_cell1.36713528
32MP0003984_embryonic_growth_retardation1.36185655
33MP0002088_abnormal_embryonic_growth/wei1.35578971
34MP0005075_abnormal_melanosome_morpholog1.33122274
35MP0000371_diluted_coat_color1.32304077
36MP0004084_abnormal_cardiac_muscle1.30742923
37MP0003705_abnormal_hypodermis_morpholog1.26498840
38MP0005076_abnormal_cell_differentiation1.22858746
39MP0004957_abnormal_blastocyst_morpholog1.21998194
40MP0008007_abnormal_cellular_replicative1.21666558
41MP0008260_abnormal_autophagy1.19173926
42MP0005380_embryogenesis_phenotype1.19103461
43MP0001672_abnormal_embryogenesis/_devel1.19103461
44MP0002086_abnormal_extraembryonic_tissu1.17678745
45MP0010307_abnormal_tumor_latency1.16485996
46MP0010678_abnormal_skin_adnexa1.14921061
47MP0003656_abnormal_erythrocyte_physiolo1.14224357
48MP0008058_abnormal_DNA_repair1.13398182
49MP0003693_abnormal_embryo_hatching1.12884644
50MP0005167_abnormal_blood-brain_barrier1.12153087
51MP0002928_abnormal_bile_duct1.11963766
52MP0005310_abnormal_salivary_gland1.11883733
53MP0003724_increased_susceptibility_to1.10151411
54MP0004484_altered_response_of1.09412760
55MP0005266_abnormal_metabolism1.08157627
56MP0002019_abnormal_tumor_incidence1.02438367
57MP0003567_abnormal_fetal_cardiomyocyte1.02296979
58MP0006292_abnormal_olfactory_placode1.01741067
59MP0003091_abnormal_cell_migration1.01078996
60MP0005451_abnormal_body_composition0.96823959
61MP0003941_abnormal_skin_development0.94413048
62MP0006138_congestive_heart_failure0.93447218
63MP0005187_abnormal_penis_morphology0.93441392
64MP0000350_abnormal_cell_proliferation0.92564819
65MP0009697_abnormal_copulation0.92414519
66MP0004036_abnormal_muscle_relaxation0.91249022
67MP0010630_abnormal_cardiac_muscle0.88356299
68MP0009115_abnormal_fat_cell0.88019325
69MP0004197_abnormal_fetal_growth/weight/0.82968850
70MP0001191_abnormal_skin_condition0.82856704
71MP0003300_gastrointestinal_ulcer0.82684608
72MP0003632_abnormal_nervous_system0.82069519
73MP0000689_abnormal_spleen_morphology0.82050267
74MP0008004_abnormal_stomach_pH0.81625803
75MP0001800_abnormal_humoral_immune0.81336255
76MP0004264_abnormal_extraembryonic_tissu0.77403952
77MP0005621_abnormal_cell_physiology0.75739647
78MP0008877_abnormal_DNA_methylation0.75630113
79MP0000767_abnormal_smooth_muscle0.75224462
80MP0002160_abnormal_reproductive_system0.74902030
81MP0001697_abnormal_embryo_size0.74420990
82MP0002398_abnormal_bone_marrow0.72312539
83MP0002405_respiratory_system_inflammati0.71752805
84MP0001915_intracranial_hemorrhage0.71653982
85MP0001835_abnormal_antigen_presentation0.70432778
86MP0001784_abnormal_fluid_regulation0.67252226
87MP0002925_abnormal_cardiovascular_devel0.64945238
88MP0000428_abnormal_craniofacial_morphol0.64169699
89MP0002722_abnormal_immune_system0.64058855
90MP0002452_abnormal_antigen_presenting0.61389584
91MP0002168_other_aberrant_phenotype0.61186419
92MP0003303_peritoneal_inflammation0.60707015
93MP0005384_cellular_phenotype0.60543305
94MP0001730_embryonic_growth_arrest0.60374313
95MP0003172_abnormal_lysosome_physiology0.60310777
96MP0005395_other_phenotype0.59231632
97MP0003868_abnormal_feces_composition0.58511684
98MP0005376_homeostasis/metabolism_phenot0.58192423
99MP0002138_abnormal_hepatobiliary_system0.58015846
100MP0002128_abnormal_blood_circulation0.55470774

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.42569149
2Abnormality of T cell number (HP:0011839)3.40711673
3IgA deficiency (HP:0002720)3.28632783
4Biliary tract neoplasm (HP:0100574)3.26992119
5Hematochezia (HP:0002573)3.20441232
6Spontaneous abortion (HP:0005268)3.08377104
7Acute myeloid leukemia (HP:0004808)2.98600095
8Conjunctival telangiectasia (HP:0000524)2.87624857
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.86320810
10Basal cell carcinoma (HP:0002671)2.86115510
11Dysmetric saccades (HP:0000641)2.85903066
12Genetic anticipation (HP:0003743)2.84924684
13Amaurosis fugax (HP:0100576)2.81129884
14Birth length less than 3rd percentile (HP:0003561)2.79050065
15Protruding tongue (HP:0010808)2.78901412
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74651201
17Prominent nose (HP:0000448)2.72984720
18Abnormality of chromosome stability (HP:0003220)2.69316690
19Medulloblastoma (HP:0002885)2.69050437
20Papillary thyroid carcinoma (HP:0002895)2.67690228
21Abnormal glucose tolerance (HP:0001952)2.65127821
22Abnormality of the hepatic vasculature (HP:0006707)2.64577208
23Deep philtrum (HP:0002002)2.60024700
24Thrombocytosis (HP:0001894)2.59752965
25Short chin (HP:0000331)2.57426296
26Poikiloderma (HP:0001029)2.52750359
27Portal hypertension (HP:0001409)2.51247919
28Abnormal biliary tract physiology (HP:0012439)2.50691642
29Bile duct proliferation (HP:0001408)2.50691642
30Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50201128
31Chromsome breakage (HP:0040012)2.48720618
32Abnormal biliary tract morphology (HP:0012440)2.46974182
33Fair hair (HP:0002286)2.45374180
34Acute hepatic failure (HP:0006554)2.43171142
35Absent radius (HP:0003974)2.42383205
36Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.40003128
37Spontaneous hematomas (HP:0007420)2.39792681
38Small hand (HP:0200055)2.39234180
39Neoplasm of the small intestine (HP:0100833)2.37254756
40Abnormality of the labia majora (HP:0012881)2.36976657
41Gastrointestinal carcinoma (HP:0002672)2.32563112
42Malignant gastrointestinal tract tumors (HP:0006749)2.32563112
43Rhabdomyosarcoma (HP:0002859)2.32512701
44Colitis (HP:0002583)2.31168611
45Colon cancer (HP:0003003)2.29692348
46Enlarged kidneys (HP:0000105)2.25966779
47Esophageal varix (HP:0002040)2.25855159
48Sandal gap (HP:0001852)2.23539154
49Arterial thrombosis (HP:0004420)2.22755257
50Clumsiness (HP:0002312)2.22448004
51Absent forearm bone (HP:0003953)2.21940878
52Aplasia involving forearm bones (HP:0009822)2.21940878
53Capillary hemangiomas (HP:0005306)2.21425718
54Premature graying of hair (HP:0002216)2.19868301
55Abnormality of the epiphyses of the hand (HP:0005924)2.17610780
56Abnormality of the renal cortex (HP:0011035)2.16573118
57Myocardial infarction (HP:0001658)2.14720475
58Glucose intolerance (HP:0000833)2.14490871
59Neoplasm of the rectum (HP:0100743)2.13222512
60Choroideremia (HP:0001139)2.09016876
61Stomach cancer (HP:0012126)2.06933811
62Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.06221264
63IgM deficiency (HP:0002850)2.04631731
64Increased number of teeth (HP:0011069)2.04380301
65Gaze-evoked nystagmus (HP:0000640)2.03835239
66Abnormal auditory evoked potentials (HP:0006958)2.02260779
67Entropion (HP:0000621)1.96788985
68Agnosia (HP:0010524)1.96607240
69Subacute progressive viral hepatitis (HP:0006572)1.94578899
70Fatigue (HP:0012378)1.94436544
71Ependymoma (HP:0002888)1.94146719
72Hypoplastic labia majora (HP:0000059)1.93641338
73Reduced antithrombin III activity (HP:0001976)1.90975069
74Menstrual irregularities (HP:0000858)1.90863166
75Anal stenosis (HP:0002025)1.90815584
76Acanthocytosis (HP:0001927)1.90570669
77Tubular atrophy (HP:0000092)1.88603096
78Neonatal hypoglycemia (HP:0001998)1.88066572
79Breast hypoplasia (HP:0003187)1.87590718
80Pancreatic cysts (HP:0001737)1.87271474
81Asymmetry of the thorax (HP:0001555)1.86842076
82Myelodysplasia (HP:0002863)1.84943505
83Freckling (HP:0001480)1.84702088
84Microtia (HP:0008551)1.84278380
85Abnormality of the intrinsic pathway (HP:0010989)1.83854726
86Abnormality of DNA repair (HP:0003254)1.83059004
87Autoimmune hemolytic anemia (HP:0001890)1.82501977
88Facial diplegia (HP:0001349)1.82308832
89Thyroid carcinoma (HP:0002890)1.82261121
90Nephroblastoma (Wilms tumor) (HP:0002667)1.82239220
91Clubbing of toes (HP:0100760)1.79820786
92Overgrowth (HP:0001548)1.79669873
93Thoracolumbar scoliosis (HP:0002944)1.78788059
94Areflexia of lower limbs (HP:0002522)1.78596447
95Short humerus (HP:0005792)1.77904618
96Thyroiditis (HP:0100646)1.77790966
97Glioma (HP:0009733)1.77737501
98Recurrent bacterial skin infections (HP:0005406)1.75240724
99Embryonal renal neoplasm (HP:0011794)1.74767735
100Chronic hepatic failure (HP:0100626)1.69470620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.36232362
2BLK3.92332688
3TIE13.87607370
4ACVR1B3.38298478
5LATS13.14705678
6AKT33.01718012
7TEC2.61478183
8BRD42.60536007
9BMPR1B2.36413871
10BRSK22.34816390
11MKNK22.31529269
12NUAK12.09610854
13CDK122.08739396
14EIF2AK32.06269987
15ZAK2.01029643
16TAOK31.96443392
17TGFBR21.46682791
18INSRR1.40682046
19PKN21.36163881
20PIK3CA1.35776528
21NLK1.35016383
22MELK1.29619828
23CAMKK21.27948976
24MAP3K131.25717438
25MAP3K101.24452936
26OXSR11.23839132
27STK391.21518583
28NEK61.17702707
29BTK1.16848771
30TGFBR11.15242140
31PIK3CG1.14871257
32PDK21.13830429
33STK41.13435668
34WNK11.10243029
35ITK1.09040195
36OBSCN1.07617388
37RPS6KB21.02098664
38ERBB41.02068609
39PTK2B0.94274708
40CDK60.93620068
41MKNK10.93559331
42MAP3K140.92920792
43MAP3K70.92407353
44JAK30.89598051
45TRPM70.89115964
46GRK10.88140705
47FES0.88092574
48SGK20.84454126
49IKBKE0.82098753
50SCYL20.77581141
51WNK40.77346700
52CAMK1D0.76585694
53PIM10.75541589
54SYK0.75520735
55FGR0.74711583
56STK380.74503644
57CSK0.70711607
58SRPK10.69888930
59JAK10.68373175
60PRKAA20.64908413
61CDK40.64359604
62FGFR30.62654309
63TTN0.61281064
64IRAK20.61100799
65FLT30.60923801
66GRK60.59548568
67FGFR20.59449724
68BMPR20.58571302
69TLK10.58132615
70FER0.57062681
71PLK20.56891420
72PLK40.55083359
73MAP3K20.52186170
74IRAK10.48063109
75SGK30.46979267
76STK30.46595581
77EGFR0.46501015
78ATM0.46251137
79CDC70.46059893
80CDK80.45917030
81IRAK40.44131727
82RIPK40.43907814
83RAF10.43031054
84JAK20.42060299
85ATR0.40832504
86MAPK110.40738791
87EIF2AK20.40688761
88CAMK40.39852122
89CHEK20.39455253
90HCK0.38012344
91CHEK10.37415300
92TNIK0.36815279
93LCK0.34001467
94ADRBK10.32921501
95GRK50.32302717
96FGFR10.31999771
97MAP2K30.31730400
98CAMK1G0.31608517
99PBK0.30891952
100PDGFRB0.29350558

Predicted pathways (KEGG)

RankGene SetZ-score
1Pantothenate and CoA biosynthesis_Homo sapiens_hsa007703.19994924
2Systemic lupus erythematosus_Homo sapiens_hsa053223.10872054
3Fanconi anemia pathway_Homo sapiens_hsa034602.18479689
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12175054
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84123950
6Non-homologous end-joining_Homo sapiens_hsa034501.83497865
7Pancreatic cancer_Homo sapiens_hsa052121.82400476
8Lysine degradation_Homo sapiens_hsa003101.72103280
9p53 signaling pathway_Homo sapiens_hsa041151.68565213
10TGF-beta signaling pathway_Homo sapiens_hsa043501.67144738
11One carbon pool by folate_Homo sapiens_hsa006701.66643290
12Selenocompound metabolism_Homo sapiens_hsa004501.64703655
13Homologous recombination_Homo sapiens_hsa034401.62715307
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61549077
15Chronic myeloid leukemia_Homo sapiens_hsa052201.60557862
16Non-small cell lung cancer_Homo sapiens_hsa052231.57191803
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56683206
18Dorso-ventral axis formation_Homo sapiens_hsa043201.56425515
19B cell receptor signaling pathway_Homo sapiens_hsa046621.54111617
20Small cell lung cancer_Homo sapiens_hsa052221.53516908
21Sulfur relay system_Homo sapiens_hsa041221.53349874
22MicroRNAs in cancer_Homo sapiens_hsa052061.53034462
23Alcoholism_Homo sapiens_hsa050341.52736160
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.52429996
25Viral carcinogenesis_Homo sapiens_hsa052031.43869670
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41233590
27Cell cycle_Homo sapiens_hsa041101.39328435
28FoxO signaling pathway_Homo sapiens_hsa040681.38375371
29Hepatitis B_Homo sapiens_hsa051611.28966324
30Adherens junction_Homo sapiens_hsa045201.28634514
31Mismatch repair_Homo sapiens_hsa034301.25837428
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25521194
33Prostate cancer_Homo sapiens_hsa052151.22465676
34Thyroid cancer_Homo sapiens_hsa052161.21281118
35Apoptosis_Homo sapiens_hsa042101.19361264
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16167723
37Acute myeloid leukemia_Homo sapiens_hsa052211.16102516
38mRNA surveillance pathway_Homo sapiens_hsa030151.14407773
39ABC transporters_Homo sapiens_hsa020101.14121525
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12466091
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11697239
42Inositol phosphate metabolism_Homo sapiens_hsa005621.11011753
43Malaria_Homo sapiens_hsa051441.09258333
44Measles_Homo sapiens_hsa051621.08863659
45HIF-1 signaling pathway_Homo sapiens_hsa040661.08367905
46Leishmaniasis_Homo sapiens_hsa051401.08331913
47mTOR signaling pathway_Homo sapiens_hsa041501.07661670
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04601055
49Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03203347
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01461223
51Platelet activation_Homo sapiens_hsa046111.00582573
52TNF signaling pathway_Homo sapiens_hsa046680.99987839
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97756970
54Colorectal cancer_Homo sapiens_hsa052100.95455215
55Osteoclast differentiation_Homo sapiens_hsa043800.95307092
56RNA polymerase_Homo sapiens_hsa030200.95183781
57Toxoplasmosis_Homo sapiens_hsa051450.93935841
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.91991982
59Legionellosis_Homo sapiens_hsa051340.91832828
60T cell receptor signaling pathway_Homo sapiens_hsa046600.91739119
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87820206
62Prolactin signaling pathway_Homo sapiens_hsa049170.87749864
63Endometrial cancer_Homo sapiens_hsa052130.84657247
64Glioma_Homo sapiens_hsa052140.81471319
65Insulin resistance_Homo sapiens_hsa049310.79274848
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79181897
67RNA transport_Homo sapiens_hsa030130.78865212
68Circadian rhythm_Homo sapiens_hsa047100.78585567
69Basal transcription factors_Homo sapiens_hsa030220.77359204
70Influenza A_Homo sapiens_hsa051640.77163067
71RNA degradation_Homo sapiens_hsa030180.76343919
72Hepatitis C_Homo sapiens_hsa051600.75151172
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.74782194
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74576280
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74139370
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73066672
77Melanoma_Homo sapiens_hsa052180.72272842
78Herpes simplex infection_Homo sapiens_hsa051680.68463318
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68059575
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66037738
81Proteoglycans in cancer_Homo sapiens_hsa052050.64719224
82HTLV-I infection_Homo sapiens_hsa051660.62980598
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.61411611
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61194169
85Nucleotide excision repair_Homo sapiens_hsa034200.60549789
86ErbB signaling pathway_Homo sapiens_hsa040120.60217914
87Tuberculosis_Homo sapiens_hsa051520.59782668
88Taste transduction_Homo sapiens_hsa047420.59013274
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54930369
90Renal cell carcinoma_Homo sapiens_hsa052110.53196049
91Pathways in cancer_Homo sapiens_hsa052000.51676917
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50972771
93DNA replication_Homo sapiens_hsa030300.49116540
94Epstein-Barr virus infection_Homo sapiens_hsa051690.48511882
95Primary immunodeficiency_Homo sapiens_hsa053400.45154527
96Hippo signaling pathway_Homo sapiens_hsa043900.40838501
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40714002
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40464536
99Focal adhesion_Homo sapiens_hsa045100.38007469
100Staphylococcus aureus infection_Homo sapiens_hsa051500.36763760

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