SLC2A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.93547489
2actin-myosin filament sliding (GO:0033275)7.48662615
3muscle filament sliding (GO:0030049)7.48662615
4establishment of protein localization to mitochondrial membrane (GO:0090151)7.34700483
5regulation of skeletal muscle contraction (GO:0014819)6.92640320
6cardiac myofibril assembly (GO:0055003)6.84850266
7tricarboxylic acid cycle (GO:0006099)6.75876333
8myofibril assembly (GO:0030239)6.75190866
9carnitine shuttle (GO:0006853)6.72437833
10behavioral response to nicotine (GO:0035095)6.69675721
11negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.59946900
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.50307164
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.18725307
14actin-mediated cell contraction (GO:0070252)6.16862908
15plasma membrane repair (GO:0001778)6.13777700
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.06792839
17fatty acid transmembrane transport (GO:1902001)6.02827383
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.95582553
19negative regulation of potassium ion transmembrane transport (GO:1901380)5.87896026
20sarcoplasmic reticulum calcium ion transport (GO:0070296)5.75941531
21regulation of acyl-CoA biosynthetic process (GO:0050812)5.62520134
22cardiac muscle contraction (GO:0060048)5.57612528
23regulation of sequestering of triglyceride (GO:0010889)5.51336037
24regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.34714465
25water-soluble vitamin biosynthetic process (GO:0042364)5.25991304
26regulation of relaxation of muscle (GO:1901077)5.20673179
27cardiac muscle cell development (GO:0055013)5.15983310
28regulation of coenzyme metabolic process (GO:0051196)5.13497093
29regulation of cofactor metabolic process (GO:0051193)5.13497093
30carnitine transmembrane transport (GO:1902603)5.11780311
31striated muscle contraction (GO:0006941)5.07153538
32regulation of actin filament-based movement (GO:1903115)5.05066055
33actomyosin structure organization (GO:0031032)5.02733050
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.90413712
35somite development (GO:0061053)4.85786237
36cardiac cell development (GO:0055006)4.84416207
37creatine metabolic process (GO:0006600)4.78255450
38regulation of cell communication by electrical coupling (GO:0010649)4.78187938
39NADH metabolic process (GO:0006734)4.76223342
40skeletal muscle contraction (GO:0003009)4.72961100
41amino-acid betaine transport (GO:0015838)4.71576384
42carnitine transport (GO:0015879)4.71576384
43regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.66726361
44regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.66318071
45actin filament-based movement (GO:0030048)4.63886746
46positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.51101474
47ventricular cardiac muscle cell action potential (GO:0086005)4.45320499
482-oxoglutarate metabolic process (GO:0006103)4.37779511
49cardiac muscle hypertrophy (GO:0003300)4.37117150
50cardiac muscle tissue morphogenesis (GO:0055008)4.36528477
51response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.34279938
52adult heart development (GO:0007512)4.31316779
53bundle of His cell to Purkinje myocyte communication (GO:0086069)4.23620452
54striated muscle hypertrophy (GO:0014897)4.23427905
55heart trabecula formation (GO:0060347)4.19641212
56regulation of striated muscle contraction (GO:0006942)4.18611544
57regulation of sulfur metabolic process (GO:0042762)4.16869233
58fatty acid beta-oxidation (GO:0006635)4.15866856
59otic vesicle formation (GO:0030916)4.13622618
60skeletal muscle adaptation (GO:0043501)4.11597583
61regulation of sarcomere organization (GO:0060297)4.09049603
62cell proliferation in forebrain (GO:0021846)4.07829086
63regulation of fatty acid oxidation (GO:0046320)4.04875427
64muscle tissue morphogenesis (GO:0060415)4.03113484
65heart process (GO:0003015)3.97225201
66heart contraction (GO:0060047)3.97225201
67protein complex biogenesis (GO:0070271)3.93616338
68ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.93268228
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.92766011
70regulation of membrane repolarization (GO:0060306)3.80283966
71biotin metabolic process (GO:0006768)3.77932841
72muscle contraction (GO:0006936)3.76645138
73muscle hypertrophy (GO:0014896)3.72471341
74regulation of potassium ion transmembrane transport (GO:1901379)3.68981334
75glycogen catabolic process (GO:0005980)3.68334668
76succinate metabolic process (GO:0006105)3.66931973
77mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.66431987
78regulation of potassium ion transmembrane transporter activity (GO:1901016)3.66199550
79membrane repolarization during action potential (GO:0086011)3.61575088
80intracellular protein transmembrane import (GO:0044743)3.61282723
81primary amino compound metabolic process (GO:1901160)3.58918280
82respiratory electron transport chain (GO:0022904)3.58771393
83positive regulation of glomerulus development (GO:0090193)3.58612797
84oxidative phosphorylation (GO:0006119)3.57041149
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.56536695
86serotonin metabolic process (GO:0042428)3.55875481
87tricarboxylic acid metabolic process (GO:0072350)3.55854691
88negative regulation of response to food (GO:0032096)3.55459741
89negative regulation of appetite (GO:0032099)3.55459741
90valine metabolic process (GO:0006573)3.54920559
91mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54815600
92regulation of the force of heart contraction (GO:0002026)3.54445526
93lipid particle organization (GO:0034389)3.53232783
94oxaloacetate metabolic process (GO:0006107)3.50970453
95branched-chain amino acid catabolic process (GO:0009083)3.48992073
96muscle system process (GO:0003012)3.48054079
97striated muscle adaptation (GO:0014888)3.47847955
98positive regulation of cardiac muscle cell differentiation (GO:2000727)3.47667155
99electron transport chain (GO:0022900)3.47636563
100cell communication involved in cardiac conduction (GO:0086065)3.45613795
101chaperone-mediated protein complex assembly (GO:0051131)3.44551964
102quaternary ammonium group transport (GO:0015697)3.44282776
103glucan catabolic process (GO:0009251)3.42712340
104positive regulation of fatty acid oxidation (GO:0046321)3.42451696
105fatty acid catabolic process (GO:0009062)3.40836252
106response to inactivity (GO:0014854)3.40194281
107mitochondrial respiratory chain complex assembly (GO:0033108)3.40173854
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39646749
109lysine metabolic process (GO:0006553)3.37625081
110lysine catabolic process (GO:0006554)3.37625081
111intracellular lipid transport (GO:0032365)3.35761881
112striated muscle cell development (GO:0055002)3.35162047
113fatty acid oxidation (GO:0019395)3.35147896
114glucan biosynthetic process (GO:0009250)3.32435045
115glycogen biosynthetic process (GO:0005978)3.32435045
116aspartate family amino acid catabolic process (GO:0009068)3.32219226
117cardiac muscle hypertrophy in response to stress (GO:0014898)3.32145555
118muscle hypertrophy in response to stress (GO:0003299)3.32145555
119cardiac muscle adaptation (GO:0014887)3.32145555
120positive regulation of fatty acid beta-oxidation (GO:0032000)3.30150141
121cellular anion homeostasis (GO:0030002)3.29901178
122lipid oxidation (GO:0034440)3.28520167
123branched-chain amino acid metabolic process (GO:0009081)3.28433506
124pyrimidine ribonucleoside catabolic process (GO:0046133)3.27956957
125negative regulation of potassium ion transport (GO:0043267)3.26843247
126negative regulation of membrane potential (GO:0045837)3.25551093
127regulation of glomerulus development (GO:0090192)3.24859662
128monoubiquitinated protein deubiquitination (GO:0035520)3.19076063
129negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.16321244
130response to muscle activity (GO:0014850)3.13859407
131tooth mineralization (GO:0034505)3.13842637
132membrane depolarization during action potential (GO:0086010)3.08084150
133RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06800763
134tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06800763
135protein polyglutamylation (GO:0018095)3.06081835
136mitochondrial respiratory chain complex I assembly (GO:0032981)3.04550779
137NADH dehydrogenase complex assembly (GO:0010257)3.04550779
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04550779
139positive regulation of potassium ion transmembrane transport (GO:1901381)3.00899420
140lateral sprouting from an epithelium (GO:0060601)3.00460188
141synaptic transmission, cholinergic (GO:0007271)2.99611131
142endoderm formation (GO:0001706)2.99249360
143lung morphogenesis (GO:0060425)2.97201726
144negative regulation of cardiac muscle tissue growth (GO:0055022)2.94681088
145negative regulation of heart growth (GO:0061117)2.94681088
146negative regulation of systemic arterial blood pressure (GO:0003085)2.94566347
147positive regulation of fatty acid transport (GO:2000193)2.93803289
148positive regulation of T cell apoptotic process (GO:0070234)2.92672657
149negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92197606
150intracellular protein transmembrane transport (GO:0065002)2.92189586
151membrane repolarization (GO:0086009)2.83842983
152gamma-aminobutyric acid transport (GO:0015812)2.79379623
153pharyngeal system development (GO:0060037)2.79312172
154parturition (GO:0007567)2.79219920
155transmission of nerve impulse (GO:0019226)2.77498877
156middle ear morphogenesis (GO:0042474)2.77416918
157DNA deamination (GO:0045006)2.77289254
158positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.75655331
159limb development (GO:0060173)2.75235402
160appendage development (GO:0048736)2.75235402
161multicellular organismal signaling (GO:0035637)2.72372668
162response to pheromone (GO:0019236)2.70158837
163protein import into peroxisome matrix (GO:0016558)2.68062385
164dentate gyrus development (GO:0021542)2.67650956
165kidney morphogenesis (GO:0060993)2.67538162
166regulation of mesoderm development (GO:2000380)2.66474552
167cytochrome complex assembly (GO:0017004)2.65938085
168neuromuscular synaptic transmission (GO:0007274)2.65163696
169negative regulation of cardiac muscle tissue development (GO:0055026)2.63266510
170negative regulation of T cell differentiation in thymus (GO:0033085)2.62275279
171regulation of action potential (GO:0098900)2.61841057
172pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61738396
173regulation of heart rate by cardiac conduction (GO:0086091)2.57795783
174regulation of potassium ion transport (GO:0043266)2.57738606
175regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56555320
176dendritic spine morphogenesis (GO:0060997)2.54654902
177skeletal muscle fiber development (GO:0048741)2.54595452
178regulation of receptor binding (GO:1900120)2.53968325
179cardiac conduction (GO:0061337)2.53654804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.74559219
2TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse5.25720030
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.30808755
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.83205815
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.71634908
6EP300_21415370_ChIP-Seq_HL-1_Mouse3.59538746
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.50726141
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.50726141
9ZNF263_19887448_ChIP-Seq_K562_Human3.20829095
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93877189
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.91891344
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88705265
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.55572972
14* CLOCK_20551151_ChIP-Seq_293T_Human2.48038895
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48010358
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.41993135
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.39520627
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35190511
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35056267
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.28966645
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17404522
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.13451402
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10085532
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.10013750
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08446437
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04653601
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02778593
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01389203
29CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96869306
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.96456739
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.94922109
32VDR_22108803_ChIP-Seq_LS180_Human1.92767796
33ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92386045
34GATA4_21415370_ChIP-Seq_HL-1_Mouse1.89852339
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88456774
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87766291
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87093331
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85576754
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85439422
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83257374
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83257374
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82179258
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81147743
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73834836
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70943031
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.70018874
47IRF1_19129219_ChIP-ChIP_H3396_Human1.68487576
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67203503
49* LXR_22158963_ChIP-Seq_LIVER_Mouse1.67136273
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.67069335
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65099015
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.64609170
53PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.64352855
54REST_21632747_ChIP-Seq_MESCs_Mouse1.61357236
55GBX2_23144817_ChIP-Seq_PC3_Human1.61068862
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.58316317
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54553554
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52327533
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51080573
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49843017
61FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48743522
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48140493
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44529360
64RNF2_27304074_Chip-Seq_NSC_Mouse1.40655612
65SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40614362
66* TP53_20018659_ChIP-ChIP_R1E_Mouse1.40502716
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39202250
68* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35427982
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35066037
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33737135
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32626012
72GATA1_22025678_ChIP-Seq_K562_Human1.31444220
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31376925
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30412947
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28247251
76* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27989384
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.27920138
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26555928
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26420210
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26169559
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.26076253
82TAF15_26573619_Chip-Seq_HEK293_Human1.25705095
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25262463
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.23783199
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23530513
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22134405
87TAF2_19829295_ChIP-Seq_ESCs_Human1.18719329
88IGF1R_20145208_ChIP-Seq_DFB_Human1.18318387
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17798793
90KDM2B_26808549_Chip-Seq_DND41_Human1.16971307
91EZH2_22144423_ChIP-Seq_EOC_Human1.15662694
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15301528
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12956494
94LXR_22292898_ChIP-Seq_THP-1_Human1.12804722
95GATA1_19941826_ChIP-Seq_K562_Human1.12760708
96CTCF_27219007_Chip-Seq_Bcells_Human1.12140908
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09499021
98NCOR_22424771_ChIP-Seq_293T_Human1.09309599
99RACK7_27058665_Chip-Seq_MCF-7_Human1.09296152
100TP63_22573176_ChIP-Seq_HFKS_Human1.09294512
101NANOG_20526341_ChIP-Seq_ESCs_Human1.06867741
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06402283
103CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06227527
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04938275
105CBP_20019798_ChIP-Seq_JUKART_Human1.04912274
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04912274
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04377503
108ATF3_27146783_Chip-Seq_COLON_Human1.04250952
109ER_23166858_ChIP-Seq_MCF-7_Human1.03502394
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.03140383
111P300_19829295_ChIP-Seq_ESCs_Human1.03052647
112FUS_26573619_Chip-Seq_HEK293_Human1.02958606
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02722444
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.01517504
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01389906
116P68_20966046_ChIP-Seq_HELA_Human1.00866061
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.00295087
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00295087
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99734250
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99654120
121RUNX1_27514584_Chip-Seq_MCF-7_Human0.98973625
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98661507
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98320008
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97700338
125TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96824369
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96233257
127DROSHA_22980978_ChIP-Seq_HELA_Human0.95316228
128HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93785213
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.93449858
130P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93052903
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92818421
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.92805698
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92801067
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91853497
135TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91815712
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91812472
137CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90590741
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89524595
139CJUN_26792858_Chip-Seq_BT549_Human0.89428878
140P53_21459846_ChIP-Seq_SAOS-2_Human0.89134327
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88905631
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88905631
143SMAD4_21799915_ChIP-Seq_A2780_Human0.88530447
144GATA2_19941826_ChIP-Seq_K562_Human0.88449014
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88393450
146RXR_22108803_ChIP-Seq_LS180_Human0.87556262
147AR_21572438_ChIP-Seq_LNCaP_Human0.87171835
148SPI1_20517297_ChIP-Seq_HL60_Human0.85336774
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85097778
150UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84884954
151FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84773411
152ISL1_27105846_Chip-Seq_CPCs_Mouse0.84567063
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84565648
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.84268524
155GATA3_21878914_ChIP-Seq_MCF-7_Human0.84093177
156* FOXA2_19822575_ChIP-Seq_HepG2_Human0.83693518
157* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.83556816
158EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83506034
159NANOG_19829295_ChIP-Seq_ESCs_Human0.83469038
160SOX2_19829295_ChIP-Seq_ESCs_Human0.83469038
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.83153918
162HTT_18923047_ChIP-ChIP_STHdh_Human0.82976190
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82942438
164TP53_22573176_ChIP-Seq_HFKS_Human0.82792650
165RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82768186
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82274007
167CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82074372
168* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81394970
169CREB1_26743006_Chip-Seq_LNCaP_Human0.81243540
170P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80893901
171FOXH1_21741376_ChIP-Seq_ESCs_Human0.80513624
172OCT4_20526341_ChIP-Seq_ESCs_Human0.79415068
173WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.79143076
174TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78691121
175FOXO3_23340844_ChIP-Seq_DLD1_Human0.78591640
176KDM2B_26808549_Chip-Seq_K562_Human0.78483069
177* CTCF_21964334_Chip-Seq_Bcells_Human0.77653157
178GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77646940
179GATA1_19941827_ChIP-Seq_MEL_Mouse0.76988190
180AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76778060
181BCOR_27268052_Chip-Seq_Bcells_Human0.76605115
182ZNF274_21170338_ChIP-Seq_K562_Hela0.76180735
183* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.75733701
184* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75082081
185NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74689398
186YY1_22570637_ChIP-Seq_MALME-3M_Human0.74558910
187DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74427778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.50318162
2* MP0002837_dystrophic_cardiac_calcinosis5.17592776
3MP0004084_abnormal_cardiac_muscle4.72590366
4* MP0003646_muscle_fatigue4.68428351
5MP0000749_muscle_degeneration4.44937874
6MP0004036_abnormal_muscle_relaxation4.23051635
7MP0004215_abnormal_myocardial_fiber4.11936670
8MP0005330_cardiomyopathy3.60079854
9MP0004145_abnormal_muscle_electrophysio3.38347287
10MP0004087_abnormal_muscle_fiber3.33705858
11MP0006292_abnormal_olfactory_placode3.33294452
12* MP0004130_abnormal_muscle_cell3.30488316
13MP0000750_abnormal_muscle_regeneration3.07352082
14MP0005670_abnormal_white_adipose2.92971743
15* MP0005620_abnormal_muscle_contractility2.89403962
16* MP0002106_abnormal_muscle_physiology2.86788527
17MP0002972_abnormal_cardiac_muscle2.81809456
18MP0002269_muscular_atrophy2.63680431
19MP0000747_muscle_weakness2.59153131
20* MP0000759_abnormal_skeletal_muscle2.49648714
21MP0010630_abnormal_cardiac_muscle2.39059573
22MP0003137_abnormal_impulse_conducting2.35978590
23* MP0005369_muscle_phenotype2.35375249
24MP0005646_abnormal_pituitary_gland2.35095504
25* MP0005385_cardiovascular_system_phenoty2.33528755
26* MP0001544_abnormal_cardiovascular_syste2.33528755
27MP0004484_altered_response_of2.30589234
28* MP0005666_abnormal_adipose_tissue2.28203818
29MP0006138_congestive_heart_failure2.22367295
30MP0002653_abnormal_ependyma_morphology2.11845267
31* MP0008775_abnormal_heart_ventricle2.10687316
32MP0008789_abnormal_olfactory_epithelium2.09431415
33MP0006036_abnormal_mitochondrial_physio2.06918315
34MP0000537_abnormal_urethra_morphology2.03848101
35MP0004233_abnormal_muscle_weight1.99945702
36MP0002876_abnormal_thyroid_physiology1.97472777
37MP0003011_delayed_dark_adaptation1.96367254
38MP0003221_abnormal_cardiomyocyte_apopto1.96314120
39MP0003828_pulmonary_edema1.95608250
40MP0000049_abnormal_middle_ear1.89514108
41MP0003122_maternal_imprinting1.88506745
42MP0002332_abnormal_exercise_endurance1.81792475
43MP0009250_abnormal_appendicular_skeleto1.81668923
44MP0002160_abnormal_reproductive_system1.81536143
45MP0001485_abnormal_pinna_reflex1.77437001
46MP0003879_abnormal_hair_cell1.74177200
47MP0009053_abnormal_anal_canal1.73152211
48MP0002736_abnormal_nociception_after1.69532177
49MP0001968_abnormal_touch/_nociception1.66632798
50MP0004085_abnormal_heartbeat1.65391154
51* MP0005375_adipose_tissue_phenotype1.64707003
52MP0004133_heterotaxia1.58468625
53MP0002971_abnormal_brown_adipose1.50492927
54MP0002102_abnormal_ear_morphology1.47871866
55MP0000631_abnormal_neuroendocrine_gland1.42248536
56MP0004142_abnormal_muscle_tone1.42152267
57MP0003950_abnormal_plasma_membrane1.40950615
58MP0004885_abnormal_endolymph1.38573865
59MP0003938_abnormal_ear_development1.37860568
60MP0000372_irregular_coat_pigmentation1.35043919
61MP0002272_abnormal_nervous_system1.33634605
62MP0004510_myositis1.29978685
63MP0002127_abnormal_cardiovascular_syste1.28554307
64MP0003121_genomic_imprinting1.25466790
65MP0000013_abnormal_adipose_tissue1.25463729
66MP0005389_reproductive_system_phenotype1.25394897
67MP0002108_abnormal_muscle_morphology1.24729286
68* MP0004185_abnormal_adipocyte_glucose1.23656388
69MP0000003_abnormal_adipose_tissue1.20748398
70MP0008438_abnormal_cutaneous_collagen1.18741582
71MP0003705_abnormal_hypodermis_morpholog1.18540485
72MP0000026_abnormal_inner_ear1.16365594
73MP0003123_paternal_imprinting1.14124110
74MP0009379_abnormal_foot_pigmentation1.13783678
75MP0001905_abnormal_dopamine_level1.13297989
76MP0000678_abnormal_parathyroid_gland1.08405426
77MP0002735_abnormal_chemical_nociception1.07242643
78MP0005275_abnormal_skin_tensile1.07044072
79MP0002234_abnormal_pharynx_morphology1.06775945
80MP0000733_abnormal_muscle_development1.05910449
81MP0002638_abnormal_pupillary_reflex1.05709290
82MP0001529_abnormal_vocalization1.04402397
83MP0008872_abnormal_physiological_respon1.04022098
84MP0002733_abnormal_thermal_nociception1.03665590
85MP0005394_taste/olfaction_phenotype1.03050090
86MP0005499_abnormal_olfactory_system1.03050090
87MP0006072_abnormal_retinal_apoptosis1.03048948
88* MP0000266_abnormal_heart_morphology1.02964292
89MP0005551_abnormal_eye_electrophysiolog1.02670713
90MP0009745_abnormal_behavioral_response1.02638383
91MP0006276_abnormal_autonomic_nervous0.99780167
92MP0003567_abnormal_fetal_cardiomyocyte0.99659280
93MP0006035_abnormal_mitochondrial_morpho0.99456997
94MP0001963_abnormal_hearing_physiology0.98006697
95MP0003942_abnormal_urinary_system0.97600603
96MP0001486_abnormal_startle_reflex0.97350333
97MP0002163_abnormal_gland_morphology0.96516964
98MP0005266_abnormal_metabolism0.96086972
99MP0002277_abnormal_respiratory_mucosa0.95885838
100MP0002249_abnormal_larynx_morphology0.94857398
101MP0004147_increased_porphyrin_level0.94287877
102* MP0000343_altered_response_to0.93756944
103MP0003937_abnormal_limbs/digits/tail_de0.93212849
104MP0005165_increased_susceptibility_to0.91212828
105MP0001984_abnormal_olfaction0.90701681
106MP0003890_abnormal_embryonic-extraembry0.90638637
107MP0002734_abnormal_mechanical_nocicepti0.90019604
108MP0001440_abnormal_grooming_behavior0.89715727
109MP0002822_catalepsy0.89163240
110MP0003279_aneurysm0.87899375
111MP0003119_abnormal_digestive_system0.87190338
112MP0002932_abnormal_joint_morphology0.85303660
113MP0005386_behavior/neurological_phenoty0.85144870
114MP0004924_abnormal_behavior0.85144870
115MP0010030_abnormal_orbit_morphology0.85019847
116MP0002067_abnormal_sensory_capabilities0.80540206
117MP0001970_abnormal_pain_threshold0.79296100
118MP0005535_abnormal_body_temperature0.79184277
119MP0002752_abnormal_somatic_nervous0.78866374
120* MP0005334_abnormal_fat_pad0.77917081
121MP0004742_abnormal_vestibular_system0.77711648
122MP0002064_seizures0.77002237
123MP0004043_abnormal_pH_regulation0.76893162
124MP0003787_abnormal_imprinting0.76586940
125* MP0002078_abnormal_glucose_homeostasis0.76437838
126MP0008961_abnormal_basal_metabolism0.74970093
127MP0009384_cardiac_valve_regurgitation0.74423210
128* MP0000230_abnormal_systemic_arterial0.73744567
129MP0003566_abnormal_cell_adhesion0.73259221
130MP0010368_abnormal_lymphatic_system0.71509701
131MP0002909_abnormal_adrenal_gland0.69963493
132MP0002128_abnormal_blood_circulation0.69590190
133MP0004272_abnormal_basement_membrane0.68093844
134MP0003806_abnormal_nucleotide_metabolis0.67123472
135MP0002970_abnormal_white_adipose0.66066272
136MP0005319_abnormal_enzyme/_coenzyme0.65662115
137* MP0002118_abnormal_lipid_homeostasis0.64659614
138MP0001879_abnormal_lymphatic_vessel0.63644802
139* MP0009115_abnormal_fat_cell0.61931225
140MP0010329_abnormal_lipoprotein_level0.51203491
141MP0005623_abnormal_meninges_morphology0.49723027
142MP0005584_abnormal_enzyme/coenzyme_acti0.48682875
143MP0003948_abnormal_gas_homeostasis0.48165912
144* MP0005452_abnormal_adipose_tissue0.47559984
145MP0003959_abnormal_lean_body0.45949511
146MP0003045_fibrosis0.45722231
147MP0000767_abnormal_smooth_muscle0.44601891
148MP0003656_abnormal_erythrocyte_physiolo0.43405710
149MP0005448_abnormal_energy_balance0.42129048
150MP0003191_abnormal_cellular_cholesterol0.41104485
151MP0009780_abnormal_chondrocyte_physiolo0.39571493
152MP0005187_abnormal_penis_morphology0.39297506
153MP0001727_abnormal_embryo_implantation0.36954697
154MP0005332_abnormal_amino_acid0.36507736
155MP0002925_abnormal_cardiovascular_devel0.36387083
156MP0001614_abnormal_blood_vessel0.35139773
157MP0005451_abnormal_body_composition0.33492511
158MP0001661_extended_life_span0.28921298
159MP0001784_abnormal_fluid_regulation0.28659688
160MP0001958_emphysema0.28477023
161MP0005376_homeostasis/metabolism_phenot0.28202722
162MP0000249_abnormal_blood_vessel0.27935057
163MP0005595_abnormal_vascular_smooth0.27511666
164MP0005167_abnormal_blood-brain_barrier0.26994441
165MP0009643_abnormal_urine_homeostasis0.26314234
166* MP0000609_abnormal_liver_physiology0.26010672

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.02307214
2Exercise-induced muscle cramps (HP:0003710)6.56305172
3Sudden death (HP:0001699)6.43632117
4Calf muscle hypertrophy (HP:0008981)6.42335161
5Muscle hypertrophy of the lower extremities (HP:0008968)6.29945677
6Muscle fiber splitting (HP:0003555)5.90975293
7Myoglobinuria (HP:0002913)5.84550727
8Ventricular tachycardia (HP:0004756)5.50867813
9Hyporeflexia of lower limbs (HP:0002600)5.19002735
10Abnormality of the calf musculature (HP:0001430)4.90889953
11Difficulty running (HP:0009046)4.86956068
12Muscle fiber inclusion bodies (HP:0100299)4.76673031
13Increased connective tissue (HP:0009025)4.65321999
14Rhabdomyolysis (HP:0003201)4.63938723
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.58450714
16Lipoatrophy (HP:0100578)4.44578987
17Atrial fibrillation (HP:0005110)4.44104516
18Subaortic stenosis (HP:0001682)4.40983996
19Abnormality of the left ventricular outflow tract (HP:0011103)4.40983996
20Type 1 muscle fiber predominance (HP:0003803)4.30655390
21EMG: myopathic abnormalities (HP:0003458)4.25184056
22Absent phalangeal crease (HP:0006109)4.22319522
23Cutaneous melanoma (HP:0012056)4.15543536
24Primary atrial arrhythmia (HP:0001692)4.13555914
25Right ventricular cardiomyopathy (HP:0011663)4.05148384
26Supraventricular tachycardia (HP:0004755)3.98904374
27Nemaline bodies (HP:0003798)3.95229916
28Supraventricular arrhythmia (HP:0005115)3.92573626
29Myotonia (HP:0002486)3.86049022
30Bundle branch block (HP:0011710)3.71758211
31Dilated cardiomyopathy (HP:0001644)3.71582084
32Asymmetric septal hypertrophy (HP:0001670)3.70533807
33Palpitations (HP:0001962)3.66813230
34Muscle stiffness (HP:0003552)3.57022494
35Abnormality of the proximal phalanges of the hand (HP:0009834)3.45902514
36Hyperglycinemia (HP:0002154)3.42782578
37Abnormal finger flexion creases (HP:0006143)3.38798494
38Syncope (HP:0001279)3.36223245
39Methylmalonic acidemia (HP:0002912)3.35768200
40Increased variability in muscle fiber diameter (HP:0003557)3.25645080
41Difficulty climbing stairs (HP:0003551)3.22298074
42Prolonged QT interval (HP:0001657)3.18455689
43Abnormality of skeletal muscle fiber size (HP:0012084)3.18103624
44Symphalangism affecting the phalanges of the hand (HP:0009773)3.11719444
45Heart block (HP:0012722)3.09667954
46Ventricular arrhythmia (HP:0004308)3.07647709
47Abnormality of the middle phalanges of the toes (HP:0010183)3.00135316
48Atrioventricular block (HP:0001678)2.97097749
49Methylmalonic aciduria (HP:0012120)2.96147693
50Distal arthrogryposis (HP:0005684)2.93018683
51Abnormal atrioventricular conduction (HP:0005150)2.92661496
52Neck muscle weakness (HP:0000467)2.88365978
53Nephronophthisis (HP:0000090)2.87056390
54Ketoacidosis (HP:0001993)2.86851653
55Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.85936105
56Myopathic facies (HP:0002058)2.80712845
57Abnormality of the phalanges of the 5th finger (HP:0004213)2.76047242
58Fibular aplasia (HP:0002990)2.74906560
59Hepatic necrosis (HP:0002605)2.74584999
60Round ear (HP:0100830)2.69072911
61Areflexia of lower limbs (HP:0002522)2.67563635
62Increased muscle lipid content (HP:0009058)2.66355135
63Distal lower limb muscle weakness (HP:0009053)2.64670648
64Abnormality of fatty-acid metabolism (HP:0004359)2.63561850
65Hypoglycemic coma (HP:0001325)2.63456244
66Morphological abnormality of the middle ear (HP:0008609)2.62167516
67Short 1st metacarpal (HP:0010034)2.55598636
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.55598636
69Ventricular fibrillation (HP:0001663)2.55237058
70True hermaphroditism (HP:0010459)2.54100220
71Rimmed vacuoles (HP:0003805)2.49041455
72Abnormal mitochondria in muscle tissue (HP:0008316)2.47790109
73Facial diplegia (HP:0001349)2.47047755
74Dicarboxylic aciduria (HP:0003215)2.46403287
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46403287
76Congenital stationary night blindness (HP:0007642)2.40690454
77Abnormality of midbrain morphology (HP:0002418)2.39981063
78Molar tooth sign on MRI (HP:0002419)2.39981063
79Short femoral neck (HP:0100864)2.37323253
80Acute necrotizing encephalopathy (HP:0006965)2.36057959
81Limb-girdle muscle atrophy (HP:0003797)2.35020571
82Cerebral palsy (HP:0100021)2.32037823
83Abnormality of the nasal septum (HP:0000419)2.31347109
84Testicular atrophy (HP:0000029)2.30491172
85Pancreatic cysts (HP:0001737)2.30104237
86Short hallux (HP:0010109)2.29340854
87Abnormal EKG (HP:0003115)2.28849546
88Meningioma (HP:0002858)2.28800000
89Hepatocellular necrosis (HP:0001404)2.26808838
90Left ventricular hypertrophy (HP:0001712)2.26096245
91Ketosis (HP:0001946)2.25563804
92Hyperglycinuria (HP:0003108)2.23313939
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.22943584
94Decreased circulating renin level (HP:0003351)2.22536944
95Abnormality of the 1st metacarpal (HP:0010009)2.22096473
96Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21234102
97Hypoplastic ischia (HP:0003175)2.20493797
98Ulnar deviation of the wrist (HP:0003049)2.20301722
99Conjunctival hamartoma (HP:0100780)2.19653393
100Abnormality of alanine metabolism (HP:0010916)2.19363343
101Hyperalaninemia (HP:0003348)2.19363343
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19363343
103Acute encephalopathy (HP:0006846)2.19032001
104Abnormality of serine family amino acid metabolism (HP:0010894)2.18434770
105Muscular dystrophy (HP:0003560)2.18380920
106Aplasia/Hypoplasia of the hallux (HP:0008362)2.17769656
107Mildly elevated creatine phosphokinase (HP:0008180)2.14906316
108Aplasia/Hypoplasia of the spleen (HP:0010451)2.14529358
109Waddling gait (HP:0002515)2.13282157
110Abnormality of the renal medulla (HP:0100957)2.12328249
111Humeroradial synostosis (HP:0003041)2.11646789
112Synostosis involving the elbow (HP:0003938)2.11646789
113Asplenia (HP:0001746)2.08997618
114Pancreatic fibrosis (HP:0100732)2.08706525
115Proximal amyotrophy (HP:0007126)2.08027884
116Generalized muscle weakness (HP:0003324)2.07943052
117Aplasia/Hypoplasia of the fibula (HP:0006492)2.07193340
118Palmoplantar keratoderma (HP:0000982)2.07045908
119Cerebral edema (HP:0002181)2.06393264
120Scapular winging (HP:0003691)2.06351530
121Mesomelia (HP:0003027)2.06243673
122Agitation (HP:0000713)2.05327855
123EMG: neuropathic changes (HP:0003445)2.05050735
124Exercise intolerance (HP:0003546)2.04892946
125Gowers sign (HP:0003391)2.04372957
126Insulin-resistant diabetes mellitus (HP:0000831)2.02764584
127Oligomenorrhea (HP:0000876)2.02570002
128Genetic anticipation (HP:0003743)2.02287434
129Septo-optic dysplasia (HP:0100842)2.00547518
130Frequent falls (HP:0002359)1.99798853
131Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.99580882
132Hip contracture (HP:0003273)1.99261136
133Distal lower limb amyotrophy (HP:0008944)1.98796603
134Progressive macrocephaly (HP:0004481)1.98286707
135Increased intramyocellular lipid droplets (HP:0012240)1.97820782
136Hypoplasia of the uterus (HP:0000013)1.95894418
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95618901
138Maternal diabetes (HP:0009800)1.94065776
139Abnormality of the ischium (HP:0003174)1.92123586
140Mitochondrial inheritance (HP:0001427)1.92072924
141Lactic acidosis (HP:0003128)1.90990307
142Synostosis of carpal bones (HP:0005048)1.90880138
143Limb-girdle muscle weakness (HP:0003325)1.89692575
144Congenital, generalized hypertrichosis (HP:0004540)1.89080496
145Spinal rigidity (HP:0003306)1.88923777
146Increased CSF lactate (HP:0002490)1.87698594
147Broad metatarsal (HP:0001783)1.87188574
148Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.84296547
149Visual hallucinations (HP:0002367)1.83051152
150Hamartoma of the eye (HP:0010568)1.82719643
151Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81927714
152Lymphangioma (HP:0100764)1.81624501
153Abnormality of glycine metabolism (HP:0010895)1.81446574
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76398780
155Abnormality of the vitamin B12 metabolism (HP:0004341)1.75903452
156Metabolic alkalosis (HP:0200114)1.72266187
157Abnormality of the 4th metacarpal (HP:0010012)1.71268149
158Abnormality of the renal collecting system (HP:0004742)1.71175407
159Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.69625318
160Osteomalacia (HP:0002749)1.67767047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.41511279
2FRK5.15536734
3OBSCN5.07953520
4PHKG24.45614569
5PHKG14.45614569
6PDK43.67351115
7PDK33.67351115
8TRIB33.25745018
9BCKDK3.18320096
10LMTK23.16164020
11MYLK2.78782875
12DMPK2.66517265
13MAP3K92.56950170
14PKN22.38775806
15PDK22.29317178
16GRK12.24079734
17NEK12.17241965
18PIK3CA2.06641578
19TLK12.06355149
20PINK12.06018486
21ADRBK21.90418570
22FGFR21.80075372
23STK161.79253999
24TIE11.61562235
25MUSK1.60401822
26MAP2K31.43504146
27MAP3K131.38349294
28CAMK1D1.34765924
29TXK1.33524250
30RIPK41.32661297
31MAPK131.29108827
32MAP3K71.25545070
33DYRK21.22656049
34TAOK31.20162451
35NME11.19234899
36STK241.16566554
37PRKAA21.16070826
38RIPK11.14135210
39PIK3CG1.12587201
40SIK11.12505315
41BMPR1B1.12293776
42MAPK121.11735366
43STK391.05786891
44PRKAA11.02285694
45WNK31.01498033
46PRKD11.01292320
47CAMK1G1.00196268
48MARK10.98480121
49CASK0.98262370
50PRKD20.94975405
51ILK0.93477913
52RPS6KA20.92847420
53MAP4K20.92725223
54GRK70.91812355
55MAPKAPK30.91746145
56PAK30.90535569
57SGK4940.88152009
58SGK2230.88152009
59INSRR0.87009273
60MAP3K40.86544821
61NTRK20.85676458
62SGK20.85019181
63CAMK2D0.83196672
64PDGFRA0.83173052
65STK110.81722302
66MAP3K30.74980781
67ADRBK10.74795926
68DAPK20.73294868
69ROCK10.72364304
70PRKCQ0.69347997
71TRPM70.68737467
72WNK40.67079282
73ZAK0.66074759
74NEK90.65540658
75FLT30.64017219
76TGFBR20.63489322
77MAP2K20.60691633
78STK38L0.59028484
79MAPK40.58913147
80ACVR1B0.58892936
81ABL20.56187742
82MAP3K50.55662582
83OXSR10.55343535
84CDC42BPA0.55253031
85PKN10.55213476
86ITK0.54936718
87EPHB10.54546133
88STK40.53539407
89NTRK30.52578883
90MAPKAPK50.51613540
91IKBKB0.51013528
92PRKCG0.50045292
93NUAK10.48910038
94PRKCZ0.47916745
95PDPK10.47652184
96MAP2K40.46362604
97CAMK40.45643606
98MAP2K70.45554093
99LATS10.44702379
100STK380.43043766
101ICK0.41887492
102DAPK30.41598709
103ERBB20.40873410
104DYRK30.40417872
105MAPK110.40350913
106CAMK10.40229985
107ERN10.39858720
108EPHB20.39838127
109WNK10.39659528
110AKT20.39645802
111PRKACB0.39449971
112GRK50.39302637
113CSNK1A10.39047181
114PRKACG0.38884559
115PRKCA0.38392776
116MAPK150.37370168
117VRK10.36839237
118PDK10.36586067
119ROCK20.36063211
120VRK20.35518452
121PTK60.35513484
122CAMK2G0.35499265
123RPS6KC10.35206519
124RPS6KL10.35206519
125KDR0.33842398
126KIT0.33807238
127MAP2K60.33702114
128PTK2B0.33227253
129PRKACA0.32061952
130CAMKK20.31523820
131MTOR0.30094306
132RPS6KA60.28493163
133CSNK1G20.27919170
134PRKCH0.27700407
135TAOK10.27680106
136CAMK2B0.27286634
137CAMK2A0.27140912
138LATS20.27132079
139FGFR40.26078890
140PRKD30.25081954
141FGFR30.23927444
142JAK10.23651395
143FER0.23412580
144MAP2K10.22749484
145RPS6KA10.22532855
146RET0.22277616
147SGK30.21649236
148JAK20.19140764
149RPS6KA30.17602633
150PRKCE0.16689511
151EEF2K0.15600479
152LRRK20.15180881
153PRKG10.14249597
154MAP3K110.13936514
155PDGFRB0.12503386

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.01861228
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.40536727
3Propanoate metabolism_Homo sapiens_hsa006404.04609972
4Cardiac muscle contraction_Homo sapiens_hsa042603.32471547
5Fatty acid degradation_Homo sapiens_hsa000713.20904386
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.02973565
7Dilated cardiomyopathy_Homo sapiens_hsa054143.00391726
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.91525527
9Fatty acid metabolism_Homo sapiens_hsa012122.77572609
10Carbon metabolism_Homo sapiens_hsa012002.64544339
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.58248023
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55609890
13Parkinsons disease_Homo sapiens_hsa050122.43707531
14Ribosome_Homo sapiens_hsa030102.35737493
15Phototransduction_Homo sapiens_hsa047442.33573211
16Oxidative phosphorylation_Homo sapiens_hsa001902.33513114
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.18086091
18Pyruvate metabolism_Homo sapiens_hsa006202.17814431
19Sulfur metabolism_Homo sapiens_hsa009202.14796978
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94405500
21PPAR signaling pathway_Homo sapiens_hsa033201.90845663
22Alzheimers disease_Homo sapiens_hsa050101.85640845
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82439260
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79763904
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77727221
26Linoleic acid metabolism_Homo sapiens_hsa005911.75001645
27Fatty acid biosynthesis_Homo sapiens_hsa000611.72941076
28Nicotine addiction_Homo sapiens_hsa050331.70792371
29Sulfur relay system_Homo sapiens_hsa041221.59652963
30Butanoate metabolism_Homo sapiens_hsa006501.55174780
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48263139
32Huntingtons disease_Homo sapiens_hsa050161.42148383
33Viral myocarditis_Homo sapiens_hsa054161.41568495
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36866373
35Fatty acid elongation_Homo sapiens_hsa000621.35922706
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35408216
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34304048
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32300132
39Olfactory transduction_Homo sapiens_hsa047401.31568386
40Starch and sucrose metabolism_Homo sapiens_hsa005001.30333162
41Glucagon signaling pathway_Homo sapiens_hsa049221.29951593
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24956739
43Morphine addiction_Homo sapiens_hsa050321.24525647
44* Insulin resistance_Homo sapiens_hsa049311.22876829
45* Adipocytokine signaling pathway_Homo sapiens_hsa049201.20418120
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18760056
47* Insulin signaling pathway_Homo sapiens_hsa049101.14160746
48beta-Alanine metabolism_Homo sapiens_hsa004101.13924685
49Circadian entrainment_Homo sapiens_hsa047131.09622781
50* AMPK signaling pathway_Homo sapiens_hsa041521.07966457
51Retinol metabolism_Homo sapiens_hsa008301.06950136
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06350156
53Serotonergic synapse_Homo sapiens_hsa047261.00710888
54RNA degradation_Homo sapiens_hsa030180.95985649
55Basal cell carcinoma_Homo sapiens_hsa052170.94496180
56Tryptophan metabolism_Homo sapiens_hsa003800.89683168
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88901991
58Chemical carcinogenesis_Homo sapiens_hsa052040.88264094
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87802024
60GABAergic synapse_Homo sapiens_hsa047270.87131539
61Taste transduction_Homo sapiens_hsa047420.86408706
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85417113
63Glutamatergic synapse_Homo sapiens_hsa047240.84957263
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84091696
65Cholinergic synapse_Homo sapiens_hsa047250.83500700
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81106184
67RNA polymerase_Homo sapiens_hsa030200.79716751
68Peroxisome_Homo sapiens_hsa041460.77271263
69Lysine degradation_Homo sapiens_hsa003100.76930836
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75653803
71Glycerolipid metabolism_Homo sapiens_hsa005610.73987595
72Arginine biosynthesis_Homo sapiens_hsa002200.73495308
73Focal adhesion_Homo sapiens_hsa045100.72579229
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.71703907
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69397206
76Calcium signaling pathway_Homo sapiens_hsa040200.69227874
77Phenylalanine metabolism_Homo sapiens_hsa003600.67493742
78Oxytocin signaling pathway_Homo sapiens_hsa049210.67347762
79Galactose metabolism_Homo sapiens_hsa000520.67320322
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.66834687
81HIF-1 signaling pathway_Homo sapiens_hsa040660.64353168
82Fructose and mannose metabolism_Homo sapiens_hsa000510.63521223
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63325446
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.61682908
85Arginine and proline metabolism_Homo sapiens_hsa003300.61077900
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60339525
87Hedgehog signaling pathway_Homo sapiens_hsa043400.60081454
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.59064887
89Homologous recombination_Homo sapiens_hsa034400.58938106
90Dopaminergic synapse_Homo sapiens_hsa047280.58815316
91Fat digestion and absorption_Homo sapiens_hsa049750.57640295
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57089133
93Arachidonic acid metabolism_Homo sapiens_hsa005900.55713318
94Ether lipid metabolism_Homo sapiens_hsa005650.55108546
95Renin secretion_Homo sapiens_hsa049240.54564383
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53571956
97Circadian rhythm_Homo sapiens_hsa047100.52276275
98Vitamin digestion and absorption_Homo sapiens_hsa049770.52115745
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51407908
100Tight junction_Homo sapiens_hsa045300.50327523
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49856499
102Histidine metabolism_Homo sapiens_hsa003400.48897698
103Purine metabolism_Homo sapiens_hsa002300.48375745
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48320289
105ECM-receptor interaction_Homo sapiens_hsa045120.48160681
106Salivary secretion_Homo sapiens_hsa049700.46801957
107Collecting duct acid secretion_Homo sapiens_hsa049660.45869865
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45069958
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.44271779
110MAPK signaling pathway_Homo sapiens_hsa040100.41572223
111Regulation of autophagy_Homo sapiens_hsa041400.40131081
112Gastric acid secretion_Homo sapiens_hsa049710.39245731
113Pentose phosphate pathway_Homo sapiens_hsa000300.38241417
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34798111
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34761440
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34084145
117Tyrosine metabolism_Homo sapiens_hsa003500.33173173
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31199146
119cAMP signaling pathway_Homo sapiens_hsa040240.30227100
120Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29178700
121Amoebiasis_Homo sapiens_hsa051460.27320618
122Adherens junction_Homo sapiens_hsa045200.26936032
123mTOR signaling pathway_Homo sapiens_hsa041500.26246280
124Metabolic pathways_Homo sapiens_hsa011000.25336037
125* Type II diabetes mellitus_Homo sapiens_hsa049300.22420596
126Caffeine metabolism_Homo sapiens_hsa002320.20815929
127Proteoglycans in cancer_Homo sapiens_hsa052050.18805640
128VEGF signaling pathway_Homo sapiens_hsa043700.16611127
129Platelet activation_Homo sapiens_hsa046110.16552355
130Renal cell carcinoma_Homo sapiens_hsa052110.15528079
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13380920
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.12522440
133Insulin secretion_Homo sapiens_hsa049110.12424272
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11922944
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.11191172
136ABC transporters_Homo sapiens_hsa020100.11108005
137GnRH signaling pathway_Homo sapiens_hsa049120.10626845
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.10610324
139Nitrogen metabolism_Homo sapiens_hsa009100.08890397
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.06932764
141Bile secretion_Homo sapiens_hsa049760.06253519
142Dorso-ventral axis formation_Homo sapiens_hsa043200.05114107
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03287074
144Protein digestion and absorption_Homo sapiens_hsa049740.03126947
145Ovarian steroidogenesis_Homo sapiens_hsa049130.02703016
146* FoxO signaling pathway_Homo sapiens_hsa040680.02103881
147Toxoplasmosis_Homo sapiens_hsa051450.01689727
148Small cell lung cancer_Homo sapiens_hsa052220.01195186
149Pancreatic secretion_Homo sapiens_hsa049720.00673143
150Acute myeloid leukemia_Homo sapiens_hsa05221-0.0069856

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