SLC2A4RG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier family 2 member 4 gene. The encoded protein interacts with another transcription factor, myocyte enhancer factor 2, to activate transcription of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell size (GO:0045792)4.87243811
2desmosome organization (GO:0002934)4.12223357
3COPI coating of Golgi vesicle (GO:0048205)4.04384483
4Golgi transport vesicle coating (GO:0048200)4.04384483
5proline biosynthetic process (GO:0006561)4.01101745
6focal adhesion assembly (GO:0048041)3.95941960
7cell-substrate adherens junction assembly (GO:0007045)3.95941960
8adherens junction assembly (GO:0034333)3.89806014
9apoptotic process involved in morphogenesis (GO:0060561)3.87279045
10maternal placenta development (GO:0001893)3.82315904
11regulation of mammary gland epithelial cell proliferation (GO:0033599)3.74547849
12negative regulation of fatty acid transport (GO:2000192)3.66938841
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.66518008
14activation of Rac GTPase activity (GO:0032863)3.64750377
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.58895210
16proline metabolic process (GO:0006560)3.55489765
17protein retention in ER lumen (GO:0006621)3.53627050
18regulation of cholesterol biosynthetic process (GO:0045540)3.53450752
19regulation of glucose import in response to insulin stimulus (GO:2001273)3.51574915
20basement membrane organization (GO:0071711)3.50421806
21regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.46377846
22negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.45626574
23cell-substrate junction assembly (GO:0007044)3.43878507
24regulation of fatty acid beta-oxidation (GO:0031998)3.42626094
25positive regulation of Cdc42 GTPase activity (GO:0043089)3.38901837
26glucose catabolic process (GO:0006007)3.35664101
27semaphorin-plexin signaling pathway (GO:0071526)3.30813913
28NADH metabolic process (GO:0006734)3.28657191
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.27691609
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.22063908
31atrioventricular valve morphogenesis (GO:0003181)3.20793850
32retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20250933
33regulation of extracellular matrix disassembly (GO:0010715)3.16597546
34epithelial cell-cell adhesion (GO:0090136)3.16519642
35pentose-phosphate shunt (GO:0006098)3.15390568
36ribosomal small subunit biogenesis (GO:0042274)3.13275498
37positive regulation of histone deacetylation (GO:0031065)3.03638626
38positive regulation of fatty acid beta-oxidation (GO:0032000)3.03434815
39regulation of early endosome to late endosome transport (GO:2000641)2.99304339
40insulin-like growth factor receptor signaling pathway (GO:0048009)2.94889176
41positive regulation of blood vessel endothelial cell migration (GO:0043536)2.93964988
42hemidesmosome assembly (GO:0031581)2.92000374
43mannose metabolic process (GO:0006013)2.86004932
44cell-cell junction maintenance (GO:0045217)2.83811237
45negative regulation of erythrocyte differentiation (GO:0045647)2.83618286
46regulation of apoptotic process involved in morphogenesis (GO:1902337)2.78618764
47vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78340143
48branching involved in mammary gland duct morphogenesis (GO:0060444)2.78203498
49regulation of cholesterol metabolic process (GO:0090181)2.77170130
50urea cycle (GO:0000050)2.75927052
51peptidyl-glutamic acid carboxylation (GO:0017187)2.74547258
52protein carboxylation (GO:0018214)2.74547258
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74405225
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73774757
55negative regulation of viral release from host cell (GO:1902187)2.71910530
56endothelial cell chemotaxis (GO:0035767)2.71634210
57mammary gland epithelial cell differentiation (GO:0060644)2.70657429
58apoptotic process involved in development (GO:1902742)2.68371662
59GDP-mannose metabolic process (GO:0019673)2.63825625
60modulation by virus of host morphology or physiology (GO:0019048)2.63249357
61glucose 6-phosphate metabolic process (GO:0051156)2.62323352
62embryonic skeletal joint morphogenesis (GO:0060272)2.61694627
63NADPH regeneration (GO:0006740)2.61460120
64urea metabolic process (GO:0019627)2.59983821
65pinocytosis (GO:0006907)2.58998708
66regulation of cholesterol homeostasis (GO:2000188)2.58308655
67protein localization to endosome (GO:0036010)2.55808453
68establishment of apical/basal cell polarity (GO:0035089)2.55629420
69intracellular estrogen receptor signaling pathway (GO:0030520)2.53278085
70cellular response to virus (GO:0098586)2.52628487
71low-density lipoprotein particle clearance (GO:0034383)2.51218120
72vascular endothelial growth factor signaling pathway (GO:0038084)2.49585067
73regulation of extracellular matrix organization (GO:1903053)2.48745626
74ear development (GO:0043583)2.48606660
75positive regulation of extracellular matrix organization (GO:1903055)2.48339359
76positive regulation of receptor recycling (GO:0001921)2.48096433
77barbed-end actin filament capping (GO:0051016)2.46297257
78embryonic eye morphogenesis (GO:0048048)2.42857744
79response to food (GO:0032094)2.42307131
80dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.39153979
81regulation of histone H3-K27 methylation (GO:0061085)2.39105812
82regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38596195
83activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38396224
84regulation of endothelial cell chemotaxis (GO:2001026)2.38357735
85positive regulation of lipid catabolic process (GO:0050996)2.38062070
86modulation by virus of host process (GO:0019054)2.37634258
87positive regulation of keratinocyte differentiation (GO:0045618)2.36500444
88UV protection (GO:0009650)2.36023984
89cochlea morphogenesis (GO:0090103)2.35844730
90embryonic process involved in female pregnancy (GO:0060136)2.33912067
91modulation by symbiont of host cellular process (GO:0044068)2.33834683
924-hydroxyproline metabolic process (GO:0019471)2.32283251
93positive regulation of triglyceride metabolic process (GO:0090208)2.31510462
94amyloid precursor protein catabolic process (GO:0042987)2.30717346
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.30197242
96L-phenylalanine metabolic process (GO:0006558)2.30197242
97ncRNA 3-end processing (GO:0043628)2.28967606
98nitrogen cycle metabolic process (GO:0071941)2.28946125
99monosaccharide biosynthetic process (GO:0046364)2.28902804
100cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28560260

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.60797705
2LXR_22292898_ChIP-Seq_THP-1_Human2.89027819
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86409199
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83244974
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.82200912
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.82086279
7VDR_21846776_ChIP-Seq_THP-1_Human2.70727930
8RACK7_27058665_Chip-Seq_MCF-7_Human2.62629674
9ZNF263_19887448_ChIP-Seq_K562_Human2.60054271
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.56658938
11TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43264854
12MYC_22102868_ChIP-Seq_BL_Human2.24404078
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21308990
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18827365
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.11769477
16KDM2B_26808549_Chip-Seq_DND41_Human1.93981190
17* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90429589
18TCF7_22412390_ChIP-Seq_EML_Mouse1.88055973
19ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.85937389
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81942203
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.78865741
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75894137
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75193191
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74964250
25* P68_20966046_ChIP-Seq_HELA_Human1.72236376
26DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70451582
27KDM2B_26808549_Chip-Seq_K562_Human1.66262227
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65980115
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.65209526
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62797944
31* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62258987
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.60503195
33SA1_27219007_Chip-Seq_ERYTHROID_Human1.54885995
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52543037
35CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51377632
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51052516
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49978682
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.49275070
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48261133
40* SMC4_20622854_ChIP-Seq_HELA_Human1.48196035
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47878952
42SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45970093
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44574570
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.43719787
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.42650887
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41941857
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41418949
48* CREB1_26743006_Chip-Seq_LNCaP_Human1.40768880
49ATF3_27146783_Chip-Seq_COLON_Human1.40580246
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.39033188
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.35144751
52* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34613860
53* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33965847
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33107053
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31243777
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29304693
57VDR_24763502_ChIP-Seq_THP-1_Human1.29231164
58* KDM2B_26808549_Chip-Seq_JURKAT_Human1.28178539
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27623614
60CLOCK_20551151_ChIP-Seq_293T_Human1.26823726
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26150657
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24870345
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22174234
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21142119
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20603153
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20301487
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19535262
68CTCF_27219007_Chip-Seq_Bcells_Human1.19485234
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19179803
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.18587484
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.17978282
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16331929
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16267517
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15805470
75MAF_26560356_Chip-Seq_TH2_Human1.14455699
76BCOR_27268052_Chip-Seq_Bcells_Human1.13038829
77NCOR1_26117541_ChIP-Seq_K562_Human1.12510380
78TP53_22127205_ChIP-Seq_IMR90_Human1.11837455
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.11594289
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09097401
81BCL6_27268052_Chip-Seq_Bcells_Human1.08772540
82MAF_26560356_Chip-Seq_TH1_Human1.08292136
83CTCF_26484167_Chip-Seq_Bcells_Mouse1.07500926
84CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06568351
85SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06427638
86RARB_24833708_ChIP-Seq_LIVER_Mouse1.05176658
87STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03005804
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02561454
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02530972
90RARA_24833708_ChIP-Seq_LIVER_Mouse1.01119967
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00937815
92CTCF_21964334_Chip-Seq_Bcells_Human1.00043368
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99513924
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99302413
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99301490
96XRN2_22483619_ChIP-Seq_HELA_Human0.99085201
97CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98343637
98* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98121095
99* TP63_22573176_ChIP-Seq_HFKS_Human0.97680132
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97206022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.93851442
2MP0005451_abnormal_body_composition3.60982764
3MP0004185_abnormal_adipocyte_glucose3.01515045
4MP0010234_abnormal_vibrissa_follicle2.89686729
5MP0005076_abnormal_cell_differentiation2.73128895
6MP0008438_abnormal_cutaneous_collagen2.56651536
7MP0005058_abnormal_lysosome_morphology2.47542892
8MP0002249_abnormal_larynx_morphology2.47015360
9MP0004858_abnormal_nervous_system2.33763456
10MP0001849_ear_inflammation2.28601672
11MP0005666_abnormal_adipose_tissue2.28579229
12MP0000751_myopathy2.18772672
13MP0002796_impaired_skin_barrier2.18648957
14MP0010030_abnormal_orbit_morphology2.12828064
15MP0002877_abnormal_melanocyte_morpholog2.12613028
16MP0005670_abnormal_white_adipose2.00530663
17MP0003566_abnormal_cell_adhesion1.95469242
18MP0005375_adipose_tissue_phenotype1.95224690
19MP0000678_abnormal_parathyroid_gland1.94593285
20MP0005360_urolithiasis1.88315261
21MP0003191_abnormal_cellular_cholesterol1.87613039
22MP0000003_abnormal_adipose_tissue1.82868619
23MP0005501_abnormal_skin_physiology1.78040685
24MP0000566_synostosis1.77214156
25MP0008260_abnormal_autophagy1.75185765
26MP0003453_abnormal_keratinocyte_physiol1.74500832
27MP0009840_abnormal_foam_cell1.74486467
28MP0000733_abnormal_muscle_development1.69676733
29MP0005409_darkened_coat_color1.62306643
30MP0002060_abnormal_skin_morphology1.55737987
31MP0000759_abnormal_skeletal_muscle1.43770481
32MP0004272_abnormal_basement_membrane1.43546741
33MP0004233_abnormal_muscle_weight1.40253566
34MP0000858_altered_metastatic_potential1.39993410
35MP0009384_cardiac_valve_regurgitation1.38025737
36MP0004381_abnormal_hair_follicle1.34983122
37MP0004087_abnormal_muscle_fiber1.33810928
38MP0005257_abnormal_intraocular_pressure1.30421865
39MP0005083_abnormal_biliary_tract1.26747590
40MP0000467_abnormal_esophagus_morphology1.23937586
41MP0006138_congestive_heart_failure1.23698927
42MP0003172_abnormal_lysosome_physiology1.22455002
43MP0004264_abnormal_extraembryonic_tissu1.21959541
44MP0003123_paternal_imprinting1.21695929
45MP0005330_cardiomyopathy1.21018055
46MP0002089_abnormal_postnatal_growth/wei1.21016112
47MP0002098_abnormal_vibrissa_morphology1.20235175
48MP0001873_stomach_inflammation1.19101824
49MP0000750_abnormal_muscle_regeneration1.18181588
50MP0000537_abnormal_urethra_morphology1.16522411
51MP0009780_abnormal_chondrocyte_physiolo1.16255828
52MP0001958_emphysema1.16086111
53MP0001348_abnormal_lacrimal_gland1.15101979
54MP0000747_muscle_weakness1.13847587
55MP0010630_abnormal_cardiac_muscle1.12887972
56MP0009053_abnormal_anal_canal1.12334921
57MP0003279_aneurysm1.12147962
58MP0005023_abnormal_wound_healing1.11176203
59MP0004130_abnormal_muscle_cell1.08666666
60MP0003942_abnormal_urinary_system1.08484358
61MP0005623_abnormal_meninges_morphology1.07599426
62MP0000013_abnormal_adipose_tissue1.06219335
63MP0000767_abnormal_smooth_muscle1.05830649
64MP0004510_myositis1.03512274
65MP0002108_abnormal_muscle_morphology1.02553267
66MP0002970_abnormal_white_adipose1.00536552
67MP0005275_abnormal_skin_tensile1.00387317
68MP0000749_muscle_degeneration0.99781551
69MP0005503_abnormal_tendon_morphology0.98491577
70MP0003091_abnormal_cell_migration0.98006598
71MP0000762_abnormal_tongue_morphology0.97220989
72MP0000534_abnormal_ureter_morphology0.94955412
73MP0009931_abnormal_skin_appearance0.93124576
74MP0001216_abnormal_epidermal_layer0.92937661
75MP0000681_abnormal_thyroid_gland0.92840627
76MP0002971_abnormal_brown_adipose0.92793370
77MP0001346_abnormal_lacrimal_gland0.87823842
78MP0001661_extended_life_span0.87169169
79MP0004947_skin_inflammation0.86147997
80MP0005508_abnormal_skeleton_morphology0.85633135
81MP0002932_abnormal_joint_morphology0.85210563
82MP0000579_abnormal_nail_morphology0.84319415
83MP0009278_abnormal_bone_marrow0.84270998
84MP0003115_abnormal_respiratory_system0.84247556
85MP0009672_abnormal_birth_weight0.81137764
86MP0002896_abnormal_bone_mineralization0.79268287
87MP0010771_integument_phenotype0.77245979
88MP0002269_muscular_atrophy0.77003941
89MP0000462_abnormal_digestive_system0.72954505
90MP0004782_abnormal_surfactant_physiolog0.72562575
91MP0002933_joint_inflammation0.72303178
92MP0009333_abnormal_splenocyte_physiolog0.71747566
93MP0009379_abnormal_foot_pigmentation0.71302637
94MP0000377_abnormal_hair_follicle0.69197373
95MP0001881_abnormal_mammary_gland0.68579801
96MP0002139_abnormal_hepatobiliary_system0.68433244
97MP0001243_abnormal_dermal_layer0.66974134
98MP0002113_abnormal_skeleton_development0.64595240
99MP0003879_abnormal_hair_cell0.63382949
100MP0010329_abnormal_lipoprotein_level0.63273585

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.69788353
2Increased connective tissue (HP:0009025)3.44567200
3Deep venous thrombosis (HP:0002625)3.33987279
4Distal lower limb muscle weakness (HP:0009053)3.30361936
5Premature rupture of membranes (HP:0001788)3.27610341
6Distal lower limb amyotrophy (HP:0008944)3.11900267
7Broad face (HP:0000283)3.07939797
8Stridor (HP:0010307)3.06100641
9Round ear (HP:0100830)3.04251977
10Hyperacusis (HP:0010780)3.04072543
11Cervical subluxation (HP:0003308)3.02654943
12Achilles tendon contracture (HP:0001771)3.00249418
13Myopathic facies (HP:0002058)2.94216534
14Mildly elevated creatine phosphokinase (HP:0008180)2.92355449
15Ulnar bowing (HP:0003031)2.88231709
16Abnormality of the Achilles tendon (HP:0005109)2.86017909
17Obstructive sleep apnea (HP:0002870)2.79063650
18J-shaped sella turcica (HP:0002680)2.78163455
19Cerebral aneurysm (HP:0004944)2.78079636
20Lymphangioma (HP:0100764)2.77537932
21Thin bony cortex (HP:0002753)2.72999825
22Fragile skin (HP:0001030)2.71278239
23Type 1 muscle fiber predominance (HP:0003803)2.70546717
24Vertebral compression fractures (HP:0002953)2.61625034
25Easy fatigability (HP:0003388)2.58336157
26Exercise-induced myalgia (HP:0003738)2.57206972
27Hemorrhage of the eye (HP:0011885)2.56570896
28Flat acetabular roof (HP:0003180)2.52693704
29Spinal rigidity (HP:0003306)2.48633471
30Increased variability in muscle fiber diameter (HP:0003557)2.46199337
31Bulbar palsy (HP:0001283)2.43409923
32Asymmetry of the thorax (HP:0001555)2.37687325
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.37573179
34Shallow orbits (HP:0000586)2.37066087
35Abnormality of skeletal muscle fiber size (HP:0012084)2.35306883
36Ulnar deviation of the wrist (HP:0003049)2.30255570
37Mitral regurgitation (HP:0001653)2.29899381
38Biconcave vertebral bodies (HP:0004586)2.29870720
39Upper limb amyotrophy (HP:0009129)2.29365945
40Distal upper limb amyotrophy (HP:0007149)2.29365945
41Acanthosis nigricans (HP:0000956)2.27904627
42Generalized amyotrophy (HP:0003700)2.22061003
43Abnormality of the distal phalanges of the toes (HP:0010182)2.12313827
44Blue sclerae (HP:0000592)2.11265336
45Disproportionate tall stature (HP:0001519)2.11059020
46Difficulty climbing stairs (HP:0003551)2.01197931
47Metaphyseal cupping (HP:0003021)1.99158352
48Elbow flexion contracture (HP:0002987)1.98707556
49Trismus (HP:0000211)1.97498760
50Hypertriglyceridemia (HP:0002155)1.96620874
51Reticulocytosis (HP:0001923)1.96463902
52Premature skin wrinkling (HP:0100678)1.95458500
53Advanced eruption of teeth (HP:0006288)1.93934988
54Joint stiffness (HP:0001387)1.91941736
55Axonal loss (HP:0003447)1.90792885
56Septate vagina (HP:0001153)1.89205982
57Long palpebral fissure (HP:0000637)1.87129669
58Thin ribs (HP:0000883)1.85185934
59Aneurysm (HP:0002617)1.84387264
60Atrophic scars (HP:0001075)1.83748366
61Short nail (HP:0001799)1.83668031
62Abnormality of the thoracic spine (HP:0100711)1.83352941
63Ankle contracture (HP:0006466)1.80461923
64Asymmetric septal hypertrophy (HP:0001670)1.80236151
65Cupped ribs (HP:0000887)1.79393312
66Hyperparathyroidism (HP:0000843)1.78475628
67Abnormality of the umbilical cord (HP:0010881)1.77145882
68Bowed forearm bones (HP:0003956)1.76614742
69Bowing of the arm (HP:0006488)1.76614742
70Hypercortisolism (HP:0001578)1.76468907
71Lower limb amyotrophy (HP:0007210)1.74504205
72Muscle fiber inclusion bodies (HP:0100299)1.72454520
73Back pain (HP:0003418)1.72093919
74Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71849558
75Coxa vara (HP:0002812)1.71697633
76Hyperthyroidism (HP:0000836)1.71419285
77Pterygium (HP:0001059)1.70586046
78Progressive muscle weakness (HP:0003323)1.70504980
79Bladder diverticulum (HP:0000015)1.69207704
80Nemaline bodies (HP:0003798)1.69112764
81Hyporeflexia of lower limbs (HP:0002600)1.69031899
82Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68854018
83Congenital glaucoma (HP:0001087)1.66914184
84Testicular atrophy (HP:0000029)1.66637210
85Venous abnormality (HP:0002624)1.66031476
86Neck muscle weakness (HP:0000467)1.65911581
87Spinal cord compression (HP:0002176)1.65528638
88Abdominal distention (HP:0003270)1.64767259
89Abnormality of complement system (HP:0005339)1.64168935
90Growth hormone excess (HP:0000845)1.63792677
91Dysostosis multiplex (HP:0000943)1.59622520
92Abnormal gallbladder physiology (HP:0012438)1.59594115
93Cholecystitis (HP:0001082)1.59594115
94Abnormality of the acetabulum (HP:0003170)1.58579689
95Deformed sella turcica (HP:0002681)1.58507086
96Broad distal phalanx of finger (HP:0009836)1.58359235
97Sparse lateral eyebrow (HP:0005338)1.57980427
98Flattened epiphyses (HP:0003071)1.57915568
99Ventricular tachycardia (HP:0004756)1.57841415
100Patellar dislocation (HP:0002999)1.57770180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB36.02028276
2SIK14.70511856
3EPHA23.47273816
4IRAK33.10914625
5SMG12.76305190
6ERN12.74088353
7PKN22.52201938
8ICK2.37229901
9TTN2.25943698
10NME22.24106777
11MST1R2.14425063
12PRPF4B2.10322367
13EEF2K2.04684442
14FGFR41.81027657
15RIPK11.76446208
16TESK11.74562326
17MAP2K31.49093972
18PTK61.37908157
19RPS6KB21.34508675
20MUSK1.34078933
21MAPKAPK31.32330711
22MAP3K101.30635027
23PAK41.27689273
24PTK21.24391018
25CDK121.23793160
26ARAF1.21273940
27PDGFRA1.19541210
28PRKD21.18937849
29TAOK21.16744478
30MTOR1.07422633
31MAP3K111.05903707
32ILK1.05476980
33LMTK21.03853718
34TAOK11.02601039
35PRKD30.99925194
36MET0.99574003
37TESK20.99420934
38MAP3K30.97936792
39IRAK20.96269239
40PDPK10.94836591
41RPS6KA20.93252282
42EPHB10.93057464
43CDC42BPA0.91078923
44MAP2K20.88253249
45MARK20.84139372
46RPS6KC10.79975767
47RPS6KL10.79975767
48TBK10.79885797
49CDK70.79446833
50LRRK20.78462638
51TNK20.77844538
52IRAK40.77183309
53MAP3K130.76019651
54MAP3K60.75252351
55CDK80.72557675
56BRAF0.72145677
57BMX0.71066184
58HIPK20.70808729
59PRKCI0.70504729
60MAPK110.69920261
61MAP3K10.69327873
62GRK60.67852990
63EPHB20.67380289
64MAP4K10.59913573
65RPS6KA60.59446082
66SIK30.58280173
67CDK40.57395527
68SCYL20.56009395
69LATS20.55791564
70PIM20.55056812
71RET0.52812927
72PRKG20.52740096
73DMPK0.50543658
74MAP3K70.49291422
75DDR20.49121047
76KDR0.48734204
77MAPKAPK20.48711894
78LIMK10.46899035
79VRK20.45603604
80MAP2K60.45217731
81MAPK120.45005272
82MAP3K80.44824569
83STK380.44070086
84SIK20.43265437
85NME10.42392019
86KSR20.41221092
87ZAP700.39937423
88PDK10.37710268
89CAMK2G0.36912278
90ABL20.36905399
91DYRK1B0.36716101
92NTRK10.35994855
93PRKD10.35788914
94RPS6KA10.34224818
95MAP2K10.33150153
96MAPK40.32487893
97AKT20.32465583
98CHUK0.31754164
99PHKG20.30426014
100PHKG10.30426014

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.79280512
2Sulfur relay system_Homo sapiens_hsa041222.73454043
3Notch signaling pathway_Homo sapiens_hsa043302.31243960
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.29165999
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18619958
6Pentose phosphate pathway_Homo sapiens_hsa000302.16264703
7Fructose and mannose metabolism_Homo sapiens_hsa000512.03424175
8Chronic myeloid leukemia_Homo sapiens_hsa052201.96700010
9Acute myeloid leukemia_Homo sapiens_hsa052211.96081362
10Bladder cancer_Homo sapiens_hsa052191.86908044
11Non-small cell lung cancer_Homo sapiens_hsa052231.84448916
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.83366941
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.79800233
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.78901660
15VEGF signaling pathway_Homo sapiens_hsa043701.76829616
16Insulin signaling pathway_Homo sapiens_hsa049101.73419996
17Phenylalanine metabolism_Homo sapiens_hsa003601.70180215
18Biosynthesis of amino acids_Homo sapiens_hsa012301.69633938
19Galactose metabolism_Homo sapiens_hsa000521.65790394
20AMPK signaling pathway_Homo sapiens_hsa041521.58808811
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57724495
22Thyroid cancer_Homo sapiens_hsa052161.45162871
23Pancreatic cancer_Homo sapiens_hsa052121.43285417
24Endometrial cancer_Homo sapiens_hsa052131.38626108
25mTOR signaling pathway_Homo sapiens_hsa041501.35933648
26Insulin resistance_Homo sapiens_hsa049311.34417130
27Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33634937
28Focal adhesion_Homo sapiens_hsa045101.33459371
29Arginine biosynthesis_Homo sapiens_hsa002201.32780500
30Prion diseases_Homo sapiens_hsa050201.30055328
31Longevity regulating pathway - mammal_Homo sapiens_hsa042111.29809534
32Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18950376
33Glioma_Homo sapiens_hsa052141.17660843
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.17596657
35Carbon metabolism_Homo sapiens_hsa012001.16186795
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11164738
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09839066
38Small cell lung cancer_Homo sapiens_hsa052221.06997473
39Renal cell carcinoma_Homo sapiens_hsa052111.06731738
40ECM-receptor interaction_Homo sapiens_hsa045121.06045645
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04526070
42Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02905811
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02615948
44Lysine degradation_Homo sapiens_hsa003100.99284766
45Proteoglycans in cancer_Homo sapiens_hsa052050.97711609
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.97129476
47ErbB signaling pathway_Homo sapiens_hsa040120.94067669
48Vitamin B6 metabolism_Homo sapiens_hsa007500.92153091
49Tyrosine metabolism_Homo sapiens_hsa003500.90974723
50Glucagon signaling pathway_Homo sapiens_hsa049220.90903585
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88239327
52PPAR signaling pathway_Homo sapiens_hsa033200.84022671
53Dilated cardiomyopathy_Homo sapiens_hsa054140.83424642
54Hepatitis C_Homo sapiens_hsa051600.82062491
55Prostate cancer_Homo sapiens_hsa052150.81019717
56Choline metabolism in cancer_Homo sapiens_hsa052310.80706177
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77477706
58Amoebiasis_Homo sapiens_hsa051460.76359695
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75320617
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74679869
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.74157673
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74024203
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73145586
64Complement and coagulation cascades_Homo sapiens_hsa046100.69357539
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.69078917
66GnRH signaling pathway_Homo sapiens_hsa049120.68193933
67Arginine and proline metabolism_Homo sapiens_hsa003300.67839585
68N-Glycan biosynthesis_Homo sapiens_hsa005100.67250353
69Estrogen signaling pathway_Homo sapiens_hsa049150.66793666
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66742188
71Bile secretion_Homo sapiens_hsa049760.65831709
72B cell receptor signaling pathway_Homo sapiens_hsa046620.63042877
73Melanoma_Homo sapiens_hsa052180.59290218
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.59052307
75HTLV-I infection_Homo sapiens_hsa051660.58400893
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57868094
77Ribosome_Homo sapiens_hsa030100.57214992
78Endocytosis_Homo sapiens_hsa041440.56341623
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55041915
80Prolactin signaling pathway_Homo sapiens_hsa049170.54863535
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53975973
82Tight junction_Homo sapiens_hsa045300.53542629
83Basal cell carcinoma_Homo sapiens_hsa052170.52758655
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.52501994
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51658460
86MicroRNAs in cancer_Homo sapiens_hsa052060.50483083
87Fatty acid biosynthesis_Homo sapiens_hsa000610.50233351
88Base excision repair_Homo sapiens_hsa034100.48812962
89Pyruvate metabolism_Homo sapiens_hsa006200.47526618
90Vibrio cholerae infection_Homo sapiens_hsa051100.47459220
91Melanogenesis_Homo sapiens_hsa049160.46980301
92Lysosome_Homo sapiens_hsa041420.46444983
93Colorectal cancer_Homo sapiens_hsa052100.46186257
94Inositol phosphate metabolism_Homo sapiens_hsa005620.45479960
95Apoptosis_Homo sapiens_hsa042100.45458386
96HIF-1 signaling pathway_Homo sapiens_hsa040660.44662191
97Fatty acid degradation_Homo sapiens_hsa000710.44601825
98Adherens junction_Homo sapiens_hsa045200.44566838
99Hepatitis B_Homo sapiens_hsa051610.44385285
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43119593

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