SLC2A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.32445056
2Golgi transport vesicle coating (GO:0048200)8.32445056
3sperm motility (GO:0030317)7.82356232
4fusion of sperm to egg plasma membrane (GO:0007342)7.49012750
5cilium or flagellum-dependent cell motility (GO:0001539)6.62863047
6acrosome reaction (GO:0007340)6.49549214
7sperm-egg recognition (GO:0035036)6.25099418
8cell wall macromolecule catabolic process (GO:0016998)6.15415213
9cell wall macromolecule metabolic process (GO:0044036)6.15415213
10acrosome assembly (GO:0001675)6.11431039
11axonemal dynein complex assembly (GO:0070286)6.07110545
12multicellular organism reproduction (GO:0032504)5.81235669
13spermatid development (GO:0007286)5.75707544
14endocrine pancreas development (GO:0031018)5.70510125
15regulation of cilium movement (GO:0003352)5.67746084
16binding of sperm to zona pellucida (GO:0007339)5.61105259
17epithelial cilium movement (GO:0003351)5.58186593
18cell-cell recognition (GO:0009988)5.53856619
19COPII vesicle coating (GO:0048208)5.53317430
20plasma membrane fusion (GO:0045026)5.52397767
21peptide hormone processing (GO:0016486)5.49462612
22reproduction (GO:0000003)5.17901706
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.16168889
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.14268667
25organic cation transport (GO:0015695)5.05733694
26negative regulation of inclusion body assembly (GO:0090084)4.99840641
27motile cilium assembly (GO:0044458)4.96231042
28protein maturation by protein folding (GO:0022417)4.88782735
29piRNA metabolic process (GO:0034587)4.83918841
30immunoglobulin mediated immune response (GO:0016064)4.81239919
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.79336932
32cilium movement (GO:0003341)4.69382936
33signal peptide processing (GO:0006465)4.58678005
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.57972937
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.55837839
36regulation of microtubule-based movement (GO:0060632)4.55174879
37protein retention in ER lumen (GO:0006621)4.51631594
38sperm capacitation (GO:0048240)4.36075427
39synaptonemal complex organization (GO:0070193)4.35569592
40male meiosis (GO:0007140)4.35394915
41regulation of type B pancreatic cell apoptotic process (GO:2000674)4.25074656
42B cell receptor signaling pathway (GO:0050853)4.10788838
43glandular epithelial cell differentiation (GO:0002067)4.09967108
44synaptonemal complex assembly (GO:0007130)4.09157951
45positive regulation of B cell differentiation (GO:0045579)4.08683916
46macroautophagy (GO:0016236)3.99958928
47positive regulation of antigen processing and presentation (GO:0002579)3.95635661
48activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.91317543
49cellular response to ethanol (GO:0071361)3.90888078
50insulin secretion (GO:0030073)3.90861986
51single fertilization (GO:0007338)3.90758422
52vesicle coating (GO:0006901)3.88493707
53positive regulation of gamma-delta T cell activation (GO:0046645)3.86124570
54positive regulation of glycolytic process (GO:0045821)3.85852007
55positive regulation of insulin secretion (GO:0032024)3.85845665
56lactate metabolic process (GO:0006089)3.84843241
57nucleoside diphosphate catabolic process (GO:0009134)3.77551490
58glycerol ether metabolic process (GO:0006662)3.72494264
59regulation of antigen processing and presentation (GO:0002577)3.70878974
60positive regulation of nuclease activity (GO:0032075)3.69338783
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.69052900
62calcium ion-dependent exocytosis (GO:0017156)3.68126312
63sequestering of metal ion (GO:0051238)3.67416412
64cellular response to exogenous dsRNA (GO:0071360)3.63769559
65spermatogenesis (GO:0007283)3.62786345
66regulation of B cell receptor signaling pathway (GO:0050855)3.62759938
67B cell mediated immunity (GO:0019724)3.61993850
68male gamete generation (GO:0048232)3.60681800
69intra-Golgi vesicle-mediated transport (GO:0006891)3.56769543
70fertilization (GO:0009566)3.55186548
71regulation of inclusion body assembly (GO:0090083)3.54919067
72exocrine pancreas development (GO:0031017)3.53017605
73angiotensin maturation (GO:0002003)3.51884812
74microglial cell activation (GO:0001774)3.51470274
75regulation of hypersensitivity (GO:0002883)3.45780110
76left/right pattern formation (GO:0060972)3.44153004
77type B pancreatic cell development (GO:0003323)3.43657608
78ether metabolic process (GO:0018904)3.41486760
79interferon-gamma-mediated signaling pathway (GO:0060333)3.35399786
80cellular response to unfolded protein (GO:0034620)3.35349642
81male meiosis I (GO:0007141)3.33445575
82gamete generation (GO:0007276)3.33380712
83L-alpha-amino acid transmembrane transport (GO:1902475)3.33035962
84purinergic nucleotide receptor signaling pathway (GO:0035590)3.32019286
85regulation of nuclease activity (GO:0032069)3.31645039
86intraciliary transport (GO:0042073)3.29009018
87cellular response to topologically incorrect protein (GO:0035967)3.28379431
88regulation of triglyceride catabolic process (GO:0010896)3.28273008
89glandular epithelial cell development (GO:0002068)3.28081542
90endoplasmic reticulum unfolded protein response (GO:0030968)3.26043803
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23749883
92germ cell development (GO:0007281)3.22794693
93regulation of insulin secretion (GO:0050796)3.22498197
94cytidine metabolic process (GO:0046087)3.20437484
95cytidine catabolic process (GO:0006216)3.20437484
96cytidine deamination (GO:0009972)3.20437484
97antigen processing and presentation of endogenous antigen (GO:0019883)3.19974800
98cellular process involved in reproduction in multicellular organism (GO:0022412)3.19552534
99positive thymic T cell selection (GO:0045059)3.18642316
100macrophage activation involved in immune response (GO:0002281)3.16137409
101regulation of germinal center formation (GO:0002634)3.15190079
102regulation of gamma-delta T cell activation (GO:0046643)3.13578118
103seminiferous tubule development (GO:0072520)3.12348804
104positive regulation of peptide hormone secretion (GO:0090277)3.10132911
105regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.10107522
106hormone catabolic process (GO:0042447)3.10024923
107intestinal absorption (GO:0050892)3.08376416
108protein localization to Golgi apparatus (GO:0034067)3.07449185
109regulation of skeletal muscle contraction (GO:0014819)3.06864351
110negative regulation of glycoprotein biosynthetic process (GO:0010561)3.06080279
111ER-nucleus signaling pathway (GO:0006984)3.02285128
112ER to Golgi vesicle-mediated transport (GO:0006888)3.01874607
113negative regulation of granulocyte differentiation (GO:0030853)3.01309419
114regulation of B cell differentiation (GO:0045577)3.00438196
115cell redox homeostasis (GO:0045454)3.00094772
116response to unfolded protein (GO:0006986)2.98627014
117positive regulation of peptide secretion (GO:0002793)2.97979272
118positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97277295
119indolalkylamine metabolic process (GO:0006586)2.96491846
120protein targeting to Golgi (GO:0000042)2.96266348
121sexual reproduction (GO:0019953)2.96232834
122ER overload response (GO:0006983)2.95658853
123DNA methylation involved in gamete generation (GO:0043046)2.95544103
124regulation of peptide hormone secretion (GO:0090276)2.94770312
125peptide catabolic process (GO:0043171)2.93989102
126detection of calcium ion (GO:0005513)2.93354520
127fucose catabolic process (GO:0019317)2.91816654
128L-fucose metabolic process (GO:0042354)2.91816654
129L-fucose catabolic process (GO:0042355)2.91816654
130response to topologically incorrect protein (GO:0035966)2.91359091
131peptide hormone secretion (GO:0030072)2.90482039
132tryptophan catabolic process (GO:0006569)2.89922531
133indole-containing compound catabolic process (GO:0042436)2.89922531
134indolalkylamine catabolic process (GO:0046218)2.89922531
135protein refolding (GO:0042026)2.89112272
136germinal center formation (GO:0002467)2.88623791
137regulation of peptide secretion (GO:0002791)2.88495584
138genitalia morphogenesis (GO:0035112)2.88069849
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.81744700
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.81744700
141modulation by symbiont of host immune response (GO:0052553)2.81744700
142positive regulation by symbiont of host defense response (GO:0052509)2.81744700
143modulation by symbiont of host defense response (GO:0052031)2.81744700
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.81744700
145T-helper 1 type immune response (GO:0042088)2.80351609
146pyrimidine ribonucleoside catabolic process (GO:0046133)2.79887399
147regulation of B cell apoptotic process (GO:0002902)2.78687871
148regulation of gamma-delta T cell differentiation (GO:0045586)2.75232431
149response to hydroperoxide (GO:0033194)2.75175154
150tryptophan metabolic process (GO:0006568)2.73874200
151G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.73613666
152response to peptidoglycan (GO:0032494)2.69201559
153regulation of T-helper 1 cell differentiation (GO:0045625)2.64339196
154mucosal-associated lymphoid tissue development (GO:0048537)2.63317824
155Peyers patch development (GO:0048541)2.63317824
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.60702538
157NAD biosynthetic process (GO:0009435)2.58995359
158purinergic receptor signaling pathway (GO:0035587)2.58174606
159negative regulation of mast cell activation (GO:0033004)2.57833306
160B cell homeostasis (GO:0001782)2.56558968
161cellular response to interferon-gamma (GO:0071346)2.56293983
162regulation of triglyceride metabolic process (GO:0090207)2.54223964
163killing of cells of other organism (GO:0031640)2.52915129
164disruption of cells of other organism (GO:0044364)2.52915129
165regulation of MHC class II biosynthetic process (GO:0045346)2.52718716
166regulation of triglyceride biosynthetic process (GO:0010866)2.48593917
167macrophage activation (GO:0042116)2.46998708
168positive regulation of defense response to virus by host (GO:0002230)2.46054725
169positive regulation of chemokine secretion (GO:0090197)2.44653634
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.44545128
171interkinetic nuclear migration (GO:0022027)2.43113444
172regulation of B cell proliferation (GO:0030888)2.42915495
173detection of bacterium (GO:0016045)2.42831978
174regulation of mast cell activation (GO:0033003)2.42471750
175regulation of myeloid leukocyte mediated immunity (GO:0002886)2.42306710
176regulation of interferon-alpha production (GO:0032647)2.41198456
177fructose metabolic process (GO:0006000)2.40943659
178defense response to protozoan (GO:0042832)2.40199360
179cellular extravasation (GO:0045123)2.39346021
180positive regulation of B cell proliferation (GO:0030890)2.38968606
181regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.38302406
182positive regulation of interferon-alpha production (GO:0032727)2.38095491
183positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38055721
184regulation of interferon-beta biosynthetic process (GO:0045357)2.38043796
185negative regulation of B cell apoptotic process (GO:0002903)2.37761709
186negative thymic T cell selection (GO:0045060)2.36710347
187antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34936156
188response to protozoan (GO:0001562)2.34760669
189positive regulation of B cell activation (GO:0050871)2.34589014
190carnitine transmembrane transport (GO:1902603)2.34442134
191positive T cell selection (GO:0043368)2.33565567
192carnitine transport (GO:0015879)2.33300627
193amino-acid betaine transport (GO:0015838)2.33300627
194regulation of icosanoid secretion (GO:0032303)2.33286471
195positive regulation of fatty acid transport (GO:2000193)2.32681587
196auditory receptor cell stereocilium organization (GO:0060088)2.31909503
197regulation of guanylate cyclase activity (GO:0031282)2.31339001
198positive regulation of macrophage cytokine production (GO:0060907)2.30511253
199detection of other organism (GO:0098543)2.30292709
200histamine secretion (GO:0001821)2.30107717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.60060839
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.31675528
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.36490667
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.41436121
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.76627785
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.50601581
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.93217936
8DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.71713928
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.64003037
10SCL_19346495_ChIP-Seq_HPC-7_Human2.56618654
11VDR_22108803_ChIP-Seq_LS180_Human2.51232288
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49772865
13GATA1_22025678_ChIP-Seq_K562_Human2.44607639
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43064226
15EZH2_22144423_ChIP-Seq_EOC_Human2.39852207
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32276363
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.18871172
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18655443
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.16495456
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.07905567
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05521291
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02910868
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98776393
24RUNX_20019798_ChIP-Seq_JUKART_Human1.98617435
25VDR_24787735_ChIP-Seq_THP-1_Human1.98495976
26ZNF274_21170338_ChIP-Seq_K562_Hela1.86722624
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85070734
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83605816
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.83489772
30* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.82385855
31VDR_24763502_ChIP-Seq_THP-1_Human1.80226437
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76853289
33* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73784104
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71717802
35IGF1R_20145208_ChIP-Seq_DFB_Human1.69221924
36* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.64865013
37MYB_26560356_Chip-Seq_TH2_Human1.64069385
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60349713
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58234371
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58044063
41GATA3_26560356_Chip-Seq_TH2_Human1.55926059
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.55557549
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55048857
44REST_21632747_ChIP-Seq_MESCs_Mouse1.50969997
45EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.49476138
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47947815
47ERG_20517297_ChIP-Seq_VCAP_Human1.44843462
48SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43405307
49DROSHA_22980978_ChIP-Seq_HELA_Human1.42688602
50SPI1_23127762_ChIP-Seq_K562_Human1.42500968
51VDR_21846776_ChIP-Seq_THP-1_Human1.39966458
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36804647
53ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35991044
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35674191
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35585673
56GATA3_27048872_Chip-Seq_THYMUS_Human1.35172506
57GATA3_21867929_ChIP-Seq_CD8_Mouse1.34415506
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34185669
59* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.34090895
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33803220
61* SPI1_23547873_ChIP-Seq_NB4_Human1.32528761
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32319759
63FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31114499
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30522034
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30513624
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.29953317
67GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29323000
68STAT1_17558387_ChIP-Seq_HELA_Human1.26731620
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26031085
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.25004214
71* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.23628111
72SMRT_27268052_Chip-Seq_Bcells_Human1.22699054
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.21989900
74RARA_24833708_ChIP-Seq_LIVER_Mouse1.21555259
75MYB_26560356_Chip-Seq_TH1_Human1.20277724
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18799995
77SOX2_22085726_ChIP-Seq_NPCs_Mouse1.17312015
78RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17159451
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15481786
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15341593
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15299081
82LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.14982884
83GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14285737
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12824156
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12634641
86FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12548708
87ER_23166858_ChIP-Seq_MCF-7_Human1.12034460
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11183528
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09641711
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09329669
91GF1_26923725_Chip-Seq_HPCs_Mouse1.07318044
92CIITA_25753668_ChIP-Seq_RAJI_Human1.06427225
93FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06154385
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06000207
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.05693885
96* STAT1_20625510_ChIP-Seq_HELA_Human1.05632269
97LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05325782
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05286482
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05220653
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.04608731
101CEBPB_22108803_ChIP-Seq_LS180_Human1.04041117
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03811376
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.01142769
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01129890
105IRF1_19129219_ChIP-ChIP_H3396_Human1.00825351
106GF1B_26923725_Chip-Seq_HPCs_Mouse1.00065490
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99633101
108STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98607983
109CTCF_20526341_ChIP-Seq_ESCs_Human0.98544846
110BCL6_27268052_Chip-Seq_Bcells_Human0.98162709
111GBX2_23144817_ChIP-Seq_PC3_Human0.97905670
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96988497
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.96461743
114* P53_21459846_ChIP-Seq_SAOS-2_Human0.96402762
115GATA3_21878914_ChIP-Seq_MCF-7_Human0.96281958
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.95333021
117WDR5_24793694_ChIP-Seq_LNCAP_Human0.95103610
118MYC_22102868_ChIP-Seq_BL_Human0.94904539
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94819209
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94785450
121SPI1_26923725_Chip-Seq_HPCs_Mouse0.94501172
122TAF2_19829295_ChIP-Seq_ESCs_Human0.94223592
123KDM2B_26808549_Chip-Seq_REH_Human0.93904932
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93033149
125CBP_20019798_ChIP-Seq_JUKART_Human0.92958745
126IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92958745
127TP53_22573176_ChIP-Seq_HFKS_Human0.92604726
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92476006
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92453321
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92163689
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92163689
132FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91192347
133FOXA1_25329375_ChIP-Seq_VCAP_Human0.91192347
134CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90796283
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90788295
136POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90729267
137STAT3_23295773_ChIP-Seq_U87_Human0.90568435
138* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90106333
139SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.89993463
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89842017
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89434951
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89300451
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.88850223
144ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88605850
145TCF4_23295773_ChIP-Seq_U87_Human0.88419722
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.87731723
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.87637375
148TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87602625
149RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87547806
150GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87374098
151AR_20517297_ChIP-Seq_VCAP_Human0.87026192
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86783943
153FOXH1_21741376_ChIP-Seq_ESCs_Human0.86726564
154GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86267099
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.85991616
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.85810006
157SOX2_19829295_ChIP-Seq_ESCs_Human0.85008714
158NANOG_19829295_ChIP-Seq_ESCs_Human0.85008714
159REST_18959480_ChIP-ChIP_MESCs_Mouse0.85007195
160* BCAT_22108803_ChIP-Seq_LS180_Human0.84134197
161MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84008140
162KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83953396
163ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83410609
164NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83165472
165GATA1_19941827_ChIP-Seq_MEL86_Mouse0.82743580
166NCOR_22424771_ChIP-Seq_293T_Human0.82554986
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82533118
168CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82424104
169CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82398007
170SOX2_21211035_ChIP-Seq_LN229_Human0.82176352
171P300_27268052_Chip-Seq_Bcells_Human0.81941311
172CDX2_22108803_ChIP-Seq_LS180_Human0.81801990
173NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81097717
174TP63_22573176_ChIP-Seq_HFKS_Human0.80968395
175CTCF_27219007_Chip-Seq_Bcells_Human0.80764843
176CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80419899
177CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79862767
178SMC4_20622854_ChIP-Seq_HELA_Human0.79764648
179STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.78966369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.39076939
2MP0004043_abnormal_pH_regulation4.52420844
3MP0003283_abnormal_digestive_organ4.05236121
4MP0003183_abnormal_peptide_metabolism4.00320806
5MP0002877_abnormal_melanocyte_morpholog3.75976191
6MP0003195_calcinosis3.57272284
7MP0002693_abnormal_pancreas_physiology3.56799199
8MP0001835_abnormal_antigen_presentation3.41754481
9MP0000013_abnormal_adipose_tissue3.17909345
10MP0009780_abnormal_chondrocyte_physiolo3.16803702
11MP0002909_abnormal_adrenal_gland3.12865041
12MP0001944_abnormal_pancreas_morphology3.10148018
13MP0000685_abnormal_immune_system3.03098248
14MP0003646_muscle_fatigue2.74121373
15MP0005387_immune_system_phenotype2.68977404
16MP0001790_abnormal_immune_system2.68977404
17MP0005671_abnormal_response_to2.65803327
18MP0003303_peritoneal_inflammation2.59857266
19MP0002139_abnormal_hepatobiliary_system2.58415625
20MP0000678_abnormal_parathyroid_gland2.56749181
21MP0005379_endocrine/exocrine_gland_phen2.51390453
22MP0003698_abnormal_male_reproductive2.50688548
23MP0001800_abnormal_humoral_immune2.46880344
24MP0010386_abnormal_urinary_bladder2.44856739
25MP0001929_abnormal_gametogenesis2.40110709
26MP0005670_abnormal_white_adipose2.30207249
27MP0004147_increased_porphyrin_level2.25319405
28MP0005220_abnormal_exocrine_pancreas2.24788215
29MP0001765_abnormal_ion_homeostasis2.19242579
30MP0003252_abnormal_bile_duct2.15229691
31MP0002928_abnormal_bile_duct2.13894910
32MP0004264_abnormal_extraembryonic_tissu2.11852220
33MP0002078_abnormal_glucose_homeostasis2.06257453
34MP0005000_abnormal_immune_tolerance2.05731149
35MP0002452_abnormal_antigen_presenting1.98345051
36MP0002148_abnormal_hypersensitivity_rea1.93171383
37MP0002723_abnormal_immune_serum1.92757506
38MP0009278_abnormal_bone_marrow1.92142448
39MP0002837_dystrophic_cardiac_calcinosis1.90977586
40MP0005365_abnormal_bile_salt1.89199271
41MP0005360_urolithiasis1.84457245
42MP0005058_abnormal_lysosome_morphology1.84083234
43MP0008961_abnormal_basal_metabolism1.83351675
44MP0002396_abnormal_hematopoietic_system1.82458404
45MP0002419_abnormal_innate_immunity1.82153319
46MP0005025_abnormal_response_to1.80955664
47MP0009785_altered_susceptibility_to1.80074284
48MP0004145_abnormal_muscle_electrophysio1.79097152
49MP0003172_abnormal_lysosome_physiology1.78848686
50MP0002653_abnormal_ependyma_morphology1.77425683
51MP0009643_abnormal_urine_homeostasis1.74665091
52MP0002420_abnormal_adaptive_immunity1.72201106
53MP0001819_abnormal_immune_cell1.70121295
54MP0003436_decreased_susceptibility_to1.64427771
55MP0005167_abnormal_blood-brain_barrier1.62720024
56MP0008877_abnormal_DNA_methylation1.62576228
57MP0003300_gastrointestinal_ulcer1.57258152
58MP0005464_abnormal_platelet_physiology1.56946664
59MP0000462_abnormal_digestive_system1.56676867
60MP0001545_abnormal_hematopoietic_system1.54916301
61MP0005397_hematopoietic_system_phenotyp1.54916301
62MP0010155_abnormal_intestine_physiology1.54364618
63MP0000003_abnormal_adipose_tissue1.54079378
64MP0005636_abnormal_mineral_homeostasis1.48359089
65MP0009764_decreased_sensitivity_to1.46893497
66MP0006072_abnormal_retinal_apoptosis1.44487497
67MP0005646_abnormal_pituitary_gland1.37387582
68MP0000716_abnormal_immune_system1.35499380
69MP0001845_abnormal_inflammatory_respons1.33589139
70MP0003953_abnormal_hormone_level1.32378948
71MP0001756_abnormal_urination1.31879898
72MP0002138_abnormal_hepatobiliary_system1.31627991
73MP0003724_increased_susceptibility_to1.30381664
74MP0001666_abnormal_nutrient_absorption1.29950267
75MP0002161_abnormal_fertility/fecundity1.29343891
76MP0003806_abnormal_nucleotide_metabolis1.28720443
77MP0005085_abnormal_gallbladder_physiolo1.28330168
78MP0001986_abnormal_taste_sensitivity1.27648818
79MP0000689_abnormal_spleen_morphology1.26355246
80MP0008872_abnormal_physiological_respon1.25951418
81MP0005451_abnormal_body_composition1.25707652
82MP0002166_altered_tumor_susceptibility1.24877673
83MP0006082_CNS_inflammation1.24343625
84MP0002398_abnormal_bone_marrow1.23821800
85MP0004130_abnormal_muscle_cell1.18944170
86MP0002896_abnormal_bone_mineralization1.16675153
87MP0001501_abnormal_sleep_pattern1.15747310
88MP0005266_abnormal_metabolism1.15121861
89MP0005535_abnormal_body_temperature1.15059564
90MP0003763_abnormal_thymus_physiology1.15048785
91MP0002234_abnormal_pharynx_morphology1.13645605
92MP0008469_abnormal_protein_level1.13359383
93MP0000569_abnormal_digit_pigmentation1.12738947
94MP0002210_abnormal_sex_determination1.12703108
95MP0001145_abnormal_male_reproductive1.12689821
96MP0009840_abnormal_foam_cell1.12654634
97MP0005645_abnormal_hypothalamus_physiol1.12225589
98MP0002332_abnormal_exercise_endurance1.11715923
99MP0004019_abnormal_vitamin_homeostasis1.11163639
100MP0004036_abnormal_muscle_relaxation1.10213949
101MP0002638_abnormal_pupillary_reflex1.09296367
102MP0001873_stomach_inflammation1.07120287
103MP0000604_amyloidosis1.05546205
104MP0005257_abnormal_intraocular_pressure1.03441207
105MP0003191_abnormal_cellular_cholesterol1.02075233
106MP0002118_abnormal_lipid_homeostasis1.01818354
107MP0002429_abnormal_blood_cell0.99709793
108MP0009333_abnormal_splenocyte_physiolog0.99081994
109MP0005375_adipose_tissue_phenotype0.96521590
110MP0000653_abnormal_sex_gland0.95503363
111MP0003959_abnormal_lean_body0.95059404
112MP0002722_abnormal_immune_system0.94599971
113MP0005584_abnormal_enzyme/coenzyme_acti0.94217093
114MP0002405_respiratory_system_inflammati0.93382174
115MP0008875_abnormal_xenobiotic_pharmacok0.92851993
116MP0009115_abnormal_fat_cell0.90097554
117MP0002876_abnormal_thyroid_physiology0.88790337
118MP0000015_abnormal_ear_pigmentation0.87203051
119MP0000249_abnormal_blood_vessel0.86463902
120MP0005332_abnormal_amino_acid0.85220182
121MP0005448_abnormal_energy_balance0.84580614
122MP0003075_altered_response_to0.84296109
123MP0003868_abnormal_feces_composition0.84093144
124MP0005551_abnormal_eye_electrophysiolog0.83608717
125MP0002006_tumorigenesis0.82427390
126MP0009672_abnormal_birth_weight0.81361790
127MP0001663_abnormal_digestive_system0.81152457
128MP0001533_abnormal_skeleton_physiology0.80330991
129MP0003045_fibrosis0.79034568
130MP0004270_analgesia0.78902233
131MP0000230_abnormal_systemic_arterial0.78615458
132MP0005166_decreased_susceptibility_to0.78301755
133MP0000538_abnormal_urinary_bladder0.77868215
134MP0000613_abnormal_salivary_gland0.76948419
135MP0009642_abnormal_blood_homeostasis0.76496347
136MP0005310_abnormal_salivary_gland0.76393032
137MP0000609_abnormal_liver_physiology0.76059018
138MP0002160_abnormal_reproductive_system0.75241512
139MP0010329_abnormal_lipoprotein_level0.75047054
140MP0002163_abnormal_gland_morphology0.74443207
141MP0004233_abnormal_muscle_weight0.74351040
142MP0001661_extended_life_span0.73946984
143MP0001764_abnormal_homeostasis0.72686724
144MP0008057_abnormal_DNA_replication0.72548017
145MP0002136_abnormal_kidney_physiology0.72464917
146MP0001502_abnormal_circadian_rhythm0.72008565
147MP0001270_distended_abdomen0.71222751
148MP0005376_homeostasis/metabolism_phenot0.70289948
149MP0003866_abnormal_defecation0.68042198
150MP0005084_abnormal_gallbladder_morpholo0.64957867
151MP0003879_abnormal_hair_cell0.64520356
152MP0005334_abnormal_fat_pad0.63163081
153MP0006036_abnormal_mitochondrial_physio0.61801995
154MP0005666_abnormal_adipose_tissue0.60956575
155MP0006054_spinal_hemorrhage0.60267640
156MP0000639_abnormal_adrenal_gland0.59949265
157MP0002971_abnormal_brown_adipose0.59349445
158MP0000631_abnormal_neuroendocrine_gland0.57054829
159MP0003122_maternal_imprinting0.54272385
160MP0005389_reproductive_system_phenotype0.53927458
161MP0002168_other_aberrant_phenotype0.52097568
162MP0005253_abnormal_eye_physiology0.51811002
163MP0003119_abnormal_digestive_system0.50924722
164MP0002269_muscular_atrophy0.49797447
165MP0005452_abnormal_adipose_tissue0.47327248

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.75109717
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.70186875
3Absent/shortened dynein arms (HP:0200106)6.16984826
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.16984826
5Hypoglycemic seizures (HP:0002173)5.93365989
6Chronic bronchitis (HP:0004469)5.79318604
7Hypoglycemic coma (HP:0001325)5.37963890
8Symptomatic seizures (HP:0011145)5.37415992
9Agammaglobulinemia (HP:0004432)4.97037765
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.75889446
11Abnormal respiratory motile cilium physiology (HP:0012261)4.63307288
12Rhinitis (HP:0012384)4.33264878
13Abnormal respiratory motile cilium morphology (HP:0005938)4.23699112
14Abnormal respiratory epithelium morphology (HP:0012253)4.23699112
15Insulin-resistant diabetes mellitus (HP:0000831)4.12060527
16Infertility (HP:0000789)3.91883426
17Panhypogammaglobulinemia (HP:0003139)3.89317364
18Ketoacidosis (HP:0001993)3.89229556
19Retinal atrophy (HP:0001105)3.82850553
20Hyperglycemia (HP:0003074)3.77960003
21Abnormal delayed hypersensitivity skin test (HP:0002963)3.75034929
22Chronic mucocutaneous candidiasis (HP:0002728)3.54532497
23Recurrent cutaneous fungal infections (HP:0011370)3.54532497
24Abnormality of B cell number (HP:0010975)3.52078248
25Late onset (HP:0003584)3.51526336
26Nemaline bodies (HP:0003798)3.49117567
27Muscle fiber inclusion bodies (HP:0100299)3.46430353
28Mucopolysacchariduria (HP:0008155)3.36931383
29Urinary glycosaminoglycan excretion (HP:0003541)3.36931383
30Abnormal ciliary motility (HP:0012262)3.35548503
31Nasal polyposis (HP:0100582)3.33344728
32Dysostosis multiplex (HP:0000943)3.32590653
33Abnormality of the pancreatic islet cells (HP:0006476)3.31288719
34Abnormality of endocrine pancreas physiology (HP:0012093)3.31288719
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.30380322
36Exercise-induced myalgia (HP:0003738)3.26461490
37Meningitis (HP:0001287)3.22894882
38Abnormality of the prostate (HP:0008775)3.20623465
39Pancreatic islet-cell hyperplasia (HP:0004510)3.16975592
40Bronchitis (HP:0012387)3.13364143
41Abnormality of calcium-phosphate metabolism (HP:0100530)3.10849841
42Elevated erythrocyte sedimentation rate (HP:0003565)3.08747493
43Decreased circulating renin level (HP:0003351)3.04460148
44Generalized aminoaciduria (HP:0002909)3.04223956
45Abnormality of polysaccharide metabolism (HP:0011012)3.04015774
46Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04015774
47Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04015774
48Recurrent fungal infections (HP:0002841)3.03626041
49Abnormal pancreas size (HP:0012094)3.02039028
50Large for gestational age (HP:0001520)3.00385651
51Chronic diarrhea (HP:0002028)2.99905267
52Bronchiectasis (HP:0002110)2.97251350
53Colitis (HP:0002583)2.91269690
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90923908
55B lymphocytopenia (HP:0010976)2.88388351
56Gastrointestinal stroma tumor (HP:0100723)2.83599307
57Mediastinal lymphadenopathy (HP:0100721)2.83041721
58Rhabdomyolysis (HP:0003201)2.82601882
59Ketosis (HP:0001946)2.79203154
60Prostate neoplasm (HP:0100787)2.76457847
61Recurrent viral infections (HP:0004429)2.75820288
62Hyperactive renin-angiotensin system (HP:0000841)2.69968012
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.68404867
64Insulin resistance (HP:0000855)2.67946202
65Gout (HP:0001997)2.67821322
66Hypokalemia (HP:0002900)2.67439223
67Abnormality of the nasal mucosa (HP:0000433)2.67251758
68Abnormality of T cell physiology (HP:0011840)2.66798837
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.66741168
70Hydroxyprolinuria (HP:0003080)2.65648902
71Abnormality of proline metabolism (HP:0010907)2.65648902
72Abnormal drinking behavior (HP:0030082)2.62471577
73Polydipsia (HP:0001959)2.62471577
74Congenital stationary night blindness (HP:0007642)2.61888069
75Vasculitis (HP:0002633)2.59736798
76Male infertility (HP:0003251)2.57101259
77Hyperkalemia (HP:0002153)2.53252539
78Abnormality of chloride homeostasis (HP:0011422)2.51192736
79Complement deficiency (HP:0004431)2.49648616
80IgM deficiency (HP:0002850)2.48131350
81Autoimmune thrombocytopenia (HP:0001973)2.44324098
82Recurrent skin infections (HP:0001581)2.42045533
83Hypokalemic alkalosis (HP:0001949)2.40148105
84Increased cerebral lipofuscin (HP:0011813)2.39970051
85IgA deficiency (HP:0002720)2.39735156
86Nephronophthisis (HP:0000090)2.38948481
87Abnormality of renin-angiotensin system (HP:0000847)2.36032460
88Recurrent bacterial skin infections (HP:0005406)2.35640558
89Stomach cancer (HP:0012126)2.34373849
90Abnormality of potassium homeostasis (HP:0011042)2.34325923
91Recurrent sinusitis (HP:0011108)2.32515970
92Abnormal urine output (HP:0012590)2.31961662
93Encephalitis (HP:0002383)2.31690018
94Hyperglycinuria (HP:0003108)2.29205044
95Abnormality of renal excretion (HP:0011036)2.28676252
96Abnormality of liposaccharide metabolism (HP:0010968)2.25242183
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.25242183
98Abnormality of glycolipid metabolism (HP:0010969)2.25242183
99Hyperparathyroidism (HP:0000843)2.24780592
100Abnormality of the intrinsic pathway (HP:0010989)2.24650004
101Inflammation of the large intestine (HP:0002037)2.22577188
102Abolished electroretinogram (ERG) (HP:0000550)2.21305489
103Polyuria (HP:0000103)2.20635460
104Fair hair (HP:0002286)2.20368538
105Cellulitis (HP:0100658)2.15808239
106Nephritis (HP:0000123)2.14203811
107Osteomalacia (HP:0002749)2.13150519
108Hypotension (HP:0002615)2.11996370
109Recurrent abscess formation (HP:0002722)2.11470331
110Recurrent pneumonia (HP:0006532)2.10547713
111Granulocytopenia (HP:0001913)2.10074143
112Autoimmune hemolytic anemia (HP:0001890)2.09784599
113Conjugated hyperbilirubinemia (HP:0002908)2.09772176
114Hyperphosphatemia (HP:0002905)2.08681286
115Recurrent bronchitis (HP:0002837)2.08399903
116IgG deficiency (HP:0004315)2.07856426
117Eosinophilia (HP:0001880)2.06744039
118Hyperventilation (HP:0002883)2.06554292
119Dicarboxylic aciduria (HP:0003215)2.06287131
120Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06287131
121Increased circulating renin level (HP:0000848)2.06175936
122Abnormality of the periventricular white matter (HP:0002518)2.05087369
123Abnormality of T cells (HP:0002843)2.04841008
124Molar tooth sign on MRI (HP:0002419)2.03172057
125Abnormality of midbrain morphology (HP:0002418)2.03172057
126Facial diplegia (HP:0001349)2.03026179
127Abnormality of purine metabolism (HP:0004352)2.02796600
128Dry hair (HP:0011359)2.02742933
129Gastrointestinal inflammation (HP:0004386)2.02515111
130Abdominal distention (HP:0003270)2.01786835
131Pigmentary retinal degeneration (HP:0001146)2.01778246
132Pulmonary infiltrates (HP:0002113)2.01716474
133Progressive neurologic deterioration (HP:0002344)2.01343419
134Thyroiditis (HP:0100646)2.00552352
135Protuberant abdomen (HP:0001538)1.98809545
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97849644
137Recurrent lower respiratory tract infections (HP:0002783)1.95954201
138Cerebral palsy (HP:0100021)1.95280989
139Skin rash (HP:0000988)1.94784367
140Distal arthrogryposis (HP:0005684)1.94583144
141Clumsiness (HP:0002312)1.93861916
142Myopathic facies (HP:0002058)1.93034065
143Agitation (HP:0000713)1.92088125
144Myositis (HP:0100614)1.91625766
145Abnormality of the renal medulla (HP:0100957)1.91609944
146Nausea (HP:0002018)1.91346317
147Type 1 muscle fiber predominance (HP:0003803)1.91112891
148Vacuolated lymphocytes (HP:0001922)1.88663378
149Cystic liver disease (HP:0006706)1.87037778
150Metabolic alkalosis (HP:0200114)1.85907049
151Lymphopenia (HP:0001888)1.85429917
152Hemoptysis (HP:0002105)1.84791087
153Osteomyelitis (HP:0002754)1.83829214
154Myoglobinuria (HP:0002913)1.82019109
155Restrictive lung disease (HP:0002091)1.81144225
156Dysautonomia (HP:0002459)1.80488923
157Attenuation of retinal blood vessels (HP:0007843)1.80075070
158Muscle hypertrophy of the lower extremities (HP:0008968)1.79715575
159Mutism (HP:0002300)1.79682140
160Acute lymphatic leukemia (HP:0006721)1.79562902
161Pancreatic cysts (HP:0001737)1.79199536
162Exocrine pancreatic insufficiency (HP:0001738)1.78326344
163Global brain atrophy (HP:0002283)1.77669316
164Abnormality of the renal cortex (HP:0011035)1.77311073
165Asymmetric septal hypertrophy (HP:0001670)1.76559036
166Abnormality of cells of the lymphoid lineage (HP:0012140)1.76224134
167Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.75202894
168Chest pain (HP:0100749)1.74887856
169Abnormality of male internal genitalia (HP:0000022)1.74824016
170Round ear (HP:0100830)1.74687855
171Abnormality of eosinophils (HP:0001879)1.74574850
172Abnormal glycosylation (HP:0012345)1.72951513
173Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72951513
174Abnormal protein N-linked glycosylation (HP:0012347)1.72951513
175Abnormal protein glycosylation (HP:0012346)1.72951513
176Abnormality of fatty-acid metabolism (HP:0004359)1.71913305
177Systemic lupus erythematosus (HP:0002725)1.71601279
178Glycosuria (HP:0003076)1.70775550
179Abnormality of urine glucose concentration (HP:0011016)1.70775550
180Medial flaring of the eyebrow (HP:0010747)1.70388167
181Neoplasm of head and neck (HP:0012288)1.70042934
182Prominent metopic ridge (HP:0005487)1.70041501
183Abnormality of small intestinal villus morphology (HP:0011472)1.67699807
184Villous atrophy (HP:0011473)1.67699807
185Intestinal atresia (HP:0011100)1.66821118
186Glucose intolerance (HP:0000833)1.66428565
187Hypophosphatemia (HP:0002148)1.65829601
188Glomerulonephritis (HP:0000099)1.64997563
189Unilateral renal agenesis (HP:0000122)1.64580855
190Thoracolumbar scoliosis (HP:0002944)1.63967771
191Nephropathy (HP:0000112)1.62249637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.88150573
2INSRR5.31379252
3PRKD35.30912071
4PASK4.93739566
5TESK14.07705107
6PDK44.03175948
7PDK34.03175948
8WNK43.55792165
9ACVR1B3.39006496
10RIPK43.34725966
11KIT3.24200446
12OBSCN3.04383943
13MAP4K13.01589231
14PDK22.76508978
15ICK2.43141960
16SYK2.39339293
17TLK12.39177086
18ZAK2.33645898
19TAOK32.16030450
20ERN12.12588329
21FRK2.07923874
22BLK2.01883473
23WNK31.97245158
24MAP3K21.92324317
25HIPK21.91021862
26ADRBK21.80071935
27DYRK1B1.76133977
28MAP3K141.58752201
29TEC1.55726233
30FLT31.55464331
31TBK11.53581391
32IKBKB1.42175160
33MAP3K131.38901445
34BTK1.35450031
35IRAK11.30329056
36FES1.25405783
37JAK31.24806006
38MAPK121.23624772
39LYN1.23541875
40TNK21.21560845
41PHKG21.19482986
42PHKG11.19482986
43IKBKE1.19011740
44TGFBR21.14821874
45WNK11.13610649
46BMPR21.10728267
47TYK21.09371822
48DAPK21.06337368
49GRK11.02320511
50MAPK111.02108153
51PIK3CG1.01539422
52NTRK10.99170617
53NUAK10.98778281
54MAP3K10.95700621
55MAPK70.94851143
56PRKCQ0.94693669
57BCKDK0.93758239
58MAP4K20.92850994
59TESK20.92239070
60MAP3K70.91553260
61PRKAA20.89494699
62STK380.89142815
63PTK60.88059897
64TRIB30.87791614
65STK390.85374607
66IRAK40.85144845
67CAMKK20.82976782
68LCK0.82896903
69EPHA30.81564962
70OXSR10.80592451
71PNCK0.80167700
72MAP2K20.79926569
73PTK20.79477437
74PTK2B0.79001427
75NEK90.78997621
76MET0.76721527
77MAP3K30.76710032
78VRK10.76227773
79SCYL20.75277016
80MAPK130.73886450
81TGFBR10.72531564
82PDGFRA0.68341257
83HCK0.67648944
84DYRK30.66911933
85SIK20.66208320
86CAMK1G0.66049861
87MAPK40.65743819
88MATK0.65688795
89PIM10.64485394
90PIK3CA0.64052658
91IRAK30.63284550
92TRPM70.63171087
93MAP2K30.62363829
94PDK10.61876213
95MAPKAPK50.59458423
96PRKD20.59071405
97CDC42BPA0.58819964
98ADRBK10.56604247
99IRAK20.54930199
100MAP2K60.54312066
101UHMK10.53823228
102PRKAA10.53603801
103CHUK0.52793931
104EPHB10.51415531
105GRK60.49927723
106CAMKK10.49762058
107RPS6KA50.49446655
108BRAF0.49393092
109BRSK20.49119380
110ZAP700.48802660
111MTOR0.47567760
112PDPK10.47348705
113PAK30.47296292
114PRKCH0.47044567
115GRK50.46850193
116PKN10.46227706
117MUSK0.45939198
118NEK60.44973937
119ABL10.44054629
120TXK0.40777303
121FGFR40.40306162
122AKT30.38337809
123GSK3A0.37086714
124ITK0.36900807
125NEK20.34675849
126EIF2AK30.34509086
127CSK0.34460114
128BMPR1B0.33298108
129JAK20.33296191
130CDK40.32721523
131MAPK30.31586855
132PRKG20.31565151
133MELK0.30827858
134PRKG10.30409906
135PINK10.29889208
136MAP3K100.29778541
137RPS6KA60.27164062
138CDK190.25356466
139PRKACG0.25275443
140NTRK30.25019187
141IGF1R0.24566911
142SIK10.23582642
143FER0.23118200
144GRK70.22133916
145JAK10.21933018
146RPS6KA20.21378511
147MARK20.20876356
148RET0.20688001
149PAK40.20627959
150NLK0.20516952
151RPS6KB10.20106865
152CSF1R0.19589645
153EPHA20.19150077
154CCNB10.17831762
155STK38L0.16245396
156MAPKAPK30.14406430
157PRKCE0.13382447
158CSNK1A10.12861461
159PRKCI0.12584794
160PAK20.11198506
161PDGFRB0.09303932
162PRKACA0.08817144
163STK30.08313089
164PRKDC0.07813881
165CDK30.07681292
166PRKD10.07437530
167MST1R0.07061448
168PRKCA0.06822530

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.13877007
2Asthma_Homo sapiens_hsa053104.46652892
3Protein export_Homo sapiens_hsa030604.36907633
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.23104226
5Allograft rejection_Homo sapiens_hsa053303.73086102
6Sulfur metabolism_Homo sapiens_hsa009203.42224994
7Autoimmune thyroid disease_Homo sapiens_hsa053203.38798394
8Graft-versus-host disease_Homo sapiens_hsa053323.34621887
9Staphylococcus aureus infection_Homo sapiens_hsa051503.31006758
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.26611672
11Insulin secretion_Homo sapiens_hsa049112.58304032
12Primary immunodeficiency_Homo sapiens_hsa053402.47621667
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.47614724
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.47331447
15Selenocompound metabolism_Homo sapiens_hsa004502.47226803
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37991045
17Other glycan degradation_Homo sapiens_hsa005112.23129487
18Systemic lupus erythematosus_Homo sapiens_hsa053222.21459073
19Leishmaniasis_Homo sapiens_hsa051402.15141517
20* Carbohydrate digestion and absorption_Homo sapiens_hsa049732.04622109
21Type II diabetes mellitus_Homo sapiens_hsa049301.84890356
22Vibrio cholerae infection_Homo sapiens_hsa051101.69186329
23Viral myocarditis_Homo sapiens_hsa054161.59462139
24Lysosome_Homo sapiens_hsa041421.56975426
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.56305134
26Glucagon signaling pathway_Homo sapiens_hsa049221.54389029
27N-Glycan biosynthesis_Homo sapiens_hsa005101.54084951
28Fat digestion and absorption_Homo sapiens_hsa049751.53814375
29B cell receptor signaling pathway_Homo sapiens_hsa046621.52630303
30ABC transporters_Homo sapiens_hsa020101.41179935
31Rheumatoid arthritis_Homo sapiens_hsa053231.40146453
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39543773
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36537171
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32266470
35Tuberculosis_Homo sapiens_hsa051521.30522511
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29461601
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29033846
38Tryptophan metabolism_Homo sapiens_hsa003801.26941360
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24773130
40Linoleic acid metabolism_Homo sapiens_hsa005911.23986587
41Type I diabetes mellitus_Homo sapiens_hsa049401.22310327
42Hematopoietic cell lineage_Homo sapiens_hsa046401.21519150
43Cocaine addiction_Homo sapiens_hsa050301.21111515
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.20324611
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19694993
46Pyruvate metabolism_Homo sapiens_hsa006201.19431631
47Amphetamine addiction_Homo sapiens_hsa050311.12879734
48Fatty acid degradation_Homo sapiens_hsa000711.10506176
49Folate biosynthesis_Homo sapiens_hsa007901.08472233
50Galactose metabolism_Homo sapiens_hsa000521.06824731
51Butanoate metabolism_Homo sapiens_hsa006501.02446396
52Fructose and mannose metabolism_Homo sapiens_hsa000511.02260926
53Propanoate metabolism_Homo sapiens_hsa006400.99299840
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97066238
55Nitrogen metabolism_Homo sapiens_hsa009100.95672134
56Starch and sucrose metabolism_Homo sapiens_hsa005000.94467332
57Thyroid hormone synthesis_Homo sapiens_hsa049180.91165625
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90642121
59Collecting duct acid secretion_Homo sapiens_hsa049660.90044253
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.89331296
61Toxoplasmosis_Homo sapiens_hsa051450.88913793
62Insulin resistance_Homo sapiens_hsa049310.87115984
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86988568
64Influenza A_Homo sapiens_hsa051640.86780714
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86380283
66Mineral absorption_Homo sapiens_hsa049780.86278293
67Prion diseases_Homo sapiens_hsa050200.84610006
68Pancreatic secretion_Homo sapiens_hsa049720.84365071
69Antigen processing and presentation_Homo sapiens_hsa046120.82304291
70Caffeine metabolism_Homo sapiens_hsa002320.82238293
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81615785
72Chemical carcinogenesis_Homo sapiens_hsa052040.79993648
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.79245728
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77067227
75Fatty acid metabolism_Homo sapiens_hsa012120.77063696
76Sphingolipid metabolism_Homo sapiens_hsa006000.76966794
77Renin-angiotensin system_Homo sapiens_hsa046140.76191489
78Osteoclast differentiation_Homo sapiens_hsa043800.73838113
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73690065
80Herpes simplex infection_Homo sapiens_hsa051680.73406179
81Platelet activation_Homo sapiens_hsa046110.71630315
82Circadian rhythm_Homo sapiens_hsa047100.71544395
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.70467584
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70116016
85Dorso-ventral axis formation_Homo sapiens_hsa043200.66138396
86Retinol metabolism_Homo sapiens_hsa008300.65101759
87Bile secretion_Homo sapiens_hsa049760.64426023
88Glycerolipid metabolism_Homo sapiens_hsa005610.64004836
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63088500
90Protein digestion and absorption_Homo sapiens_hsa049740.61157537
91Regulation of autophagy_Homo sapiens_hsa041400.60952848
92Histidine metabolism_Homo sapiens_hsa003400.60608447
93Estrogen signaling pathway_Homo sapiens_hsa049150.60510254
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59003314
95Pertussis_Homo sapiens_hsa051330.58866667
96PPAR signaling pathway_Homo sapiens_hsa033200.57259104
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56963756
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55365873
99Taste transduction_Homo sapiens_hsa047420.55179617
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54204069
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54049102
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52580820
103Peroxisome_Homo sapiens_hsa041460.51383163
104Phenylalanine metabolism_Homo sapiens_hsa003600.51083481
105Ovarian steroidogenesis_Homo sapiens_hsa049130.49717375
106Calcium signaling pathway_Homo sapiens_hsa040200.49651591
107Legionellosis_Homo sapiens_hsa051340.49452981
108Phototransduction_Homo sapiens_hsa047440.49219668
109Vitamin digestion and absorption_Homo sapiens_hsa049770.49186718
110Ether lipid metabolism_Homo sapiens_hsa005650.48650146
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46364992
112Lysine degradation_Homo sapiens_hsa003100.45888833
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45727365
114African trypanosomiasis_Homo sapiens_hsa051430.45670472
115Renin secretion_Homo sapiens_hsa049240.45337388
116Phagosome_Homo sapiens_hsa041450.45149780
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.44912027
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44014499
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42849589
120Long-term potentiation_Homo sapiens_hsa047200.41441707
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41390439
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39917303
123Synaptic vesicle cycle_Homo sapiens_hsa047210.39137273
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38960020
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38489958
126Arginine and proline metabolism_Homo sapiens_hsa003300.38163693
127Salivary secretion_Homo sapiens_hsa049700.36353358
128Oxytocin signaling pathway_Homo sapiens_hsa049210.35769349
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35524617
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34626349
131Prolactin signaling pathway_Homo sapiens_hsa049170.33997981
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.33989370
133AMPK signaling pathway_Homo sapiens_hsa041520.33949314
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33769138
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32747377
136Arginine biosynthesis_Homo sapiens_hsa002200.31602240
137Insulin signaling pathway_Homo sapiens_hsa049100.31102348
138Long-term depression_Homo sapiens_hsa047300.29112478
139Inositol phosphate metabolism_Homo sapiens_hsa005620.29025976
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28388686
141beta-Alanine metabolism_Homo sapiens_hsa004100.28321879
142Serotonergic synapse_Homo sapiens_hsa047260.28231704
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27283347
144Arachidonic acid metabolism_Homo sapiens_hsa005900.27248495
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27160658
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26979750
147Dopaminergic synapse_Homo sapiens_hsa047280.26487668
148Fatty acid biosynthesis_Homo sapiens_hsa000610.25860569
149Metabolic pathways_Homo sapiens_hsa011000.25089125
150Fatty acid elongation_Homo sapiens_hsa000620.23873096
151Tyrosine metabolism_Homo sapiens_hsa003500.23513433
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.22928903
153Alcoholism_Homo sapiens_hsa050340.21488032
154Carbon metabolism_Homo sapiens_hsa012000.21449670
155Circadian entrainment_Homo sapiens_hsa047130.21439604
156Drug metabolism - other enzymes_Homo sapiens_hsa009830.20753910
157Endocytosis_Homo sapiens_hsa041440.20622619
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19305655

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