SLC2A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid metabolic process (GO:0046655)4.53243026
2heme transport (GO:0015886)4.51078235
3glycine metabolic process (GO:0006544)4.51072932
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49524243
5L-phenylalanine metabolic process (GO:0006558)4.49524243
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.35776545
7L-phenylalanine catabolic process (GO:0006559)4.35776545
8lysine metabolic process (GO:0006553)4.33273348
9lysine catabolic process (GO:0006554)4.33273348
10serine family amino acid biosynthetic process (GO:0009070)4.30533755
11NADH metabolic process (GO:0006734)4.26968828
12regulation of cholesterol esterification (GO:0010872)4.23485981
13L-serine metabolic process (GO:0006563)4.22693442
14chaperone-mediated protein transport (GO:0072321)4.13586032
15serine family amino acid catabolic process (GO:0009071)4.06576428
16DNA deamination (GO:0045006)3.94697801
17serine family amino acid metabolic process (GO:0009069)3.93637515
18aspartate family amino acid catabolic process (GO:0009068)3.92303048
19alpha-linolenic acid metabolic process (GO:0036109)3.89820958
20cysteine metabolic process (GO:0006534)3.89477791
21purine nucleobase biosynthetic process (GO:0009113)3.82989580
22sulfur amino acid catabolic process (GO:0000098)3.78927536
23glyoxylate metabolic process (GO:0046487)3.76660989
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75012569
25CDP-diacylglycerol metabolic process (GO:0046341)3.74854545
26amino-acid betaine metabolic process (GO:0006577)3.73203996
27L-methionine salvage (GO:0071267)3.69312190
28L-methionine biosynthetic process (GO:0071265)3.69312190
29amino acid salvage (GO:0043102)3.69312190
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.69201534
31pantothenate metabolic process (GO:0015939)3.63356401
32iron coordination entity transport (GO:1901678)3.55544855
33sulfur amino acid biosynthetic process (GO:0000097)3.54318791
342-oxoglutarate metabolic process (GO:0006103)3.53579548
35biotin metabolic process (GO:0006768)3.53213037
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52761913
37fructose metabolic process (GO:0006000)3.42851843
38aspartate family amino acid metabolic process (GO:0009066)3.41156213
39tricarboxylic acid cycle (GO:0006099)3.39295883
40aspartate family amino acid biosynthetic process (GO:0009067)3.34760293
41peptidyl-histidine modification (GO:0018202)3.29810878
42aromatic amino acid family catabolic process (GO:0009074)3.28973456
43regulation of cholesterol homeostasis (GO:2000188)3.28899844
44folic acid transport (GO:0015884)3.27105555
45acetyl-CoA metabolic process (GO:0006084)3.24896057
46fatty acid homeostasis (GO:0055089)3.23221783
47nucleobase biosynthetic process (GO:0046112)3.23104490
48alpha-amino acid catabolic process (GO:1901606)3.21083931
49positive regulation of triglyceride biosynthetic process (GO:0010867)3.18947029
50protein-lipid complex remodeling (GO:0034368)3.17738130
51macromolecular complex remodeling (GO:0034367)3.17738130
52plasma lipoprotein particle remodeling (GO:0034369)3.17738130
53branched-chain amino acid catabolic process (GO:0009083)3.15258071
54regulation of protein activation cascade (GO:2000257)3.13762827
55reverse cholesterol transport (GO:0043691)3.13341444
56methionine biosynthetic process (GO:0009086)3.13158688
57cellular amino acid catabolic process (GO:0009063)3.12880767
58L-alpha-amino acid transmembrane transport (GO:1902475)3.10897177
59kynurenine metabolic process (GO:0070189)3.10855465
60cellular modified amino acid catabolic process (GO:0042219)3.10730954
61methionine metabolic process (GO:0006555)3.07170767
62phospholipid efflux (GO:0033700)3.07161308
63proteasome assembly (GO:0043248)3.06910807
64homocysteine metabolic process (GO:0050667)3.06788285
65regulation of complement activation (GO:0030449)3.06579325
66fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.05648113
67sulfur amino acid metabolic process (GO:0000096)3.02970861
68CDP-diacylglycerol biosynthetic process (GO:0016024)3.02013502
69plasma lipoprotein particle clearance (GO:0034381)2.99597876
70bile acid biosynthetic process (GO:0006699)2.97783611
71gluconeogenesis (GO:0006094)2.97535811
72aromatic amino acid family metabolic process (GO:0009072)2.93976792
73pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.93006574
74galactose catabolic process (GO:0019388)2.92868511
75mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89760302
76urea cycle (GO:0000050)2.89039012
77urea metabolic process (GO:0019627)2.89039012
78low-density lipoprotein particle remodeling (GO:0034374)2.88593849
79respiratory electron transport chain (GO:0022904)2.87547108
80complement activation, alternative pathway (GO:0006957)2.87345447
81electron transport chain (GO:0022900)2.86602458
82protein insertion into membrane (GO:0051205)2.86452031
83organic acid catabolic process (GO:0016054)2.83796134
84carboxylic acid catabolic process (GO:0046395)2.83796134
85water-soluble vitamin biosynthetic process (GO:0042364)2.83674351
86response to mercury ion (GO:0046689)2.83541729
87GDP-mannose metabolic process (GO:0019673)2.83205529
88cofactor transport (GO:0051181)2.83155618
89S-adenosylmethionine metabolic process (GO:0046500)2.82920899
90energy coupled proton transport, down electrochemical gradient (GO:0015985)2.82435348
91ATP synthesis coupled proton transport (GO:0015986)2.82435348
92regulation of cholesterol biosynthetic process (GO:0045540)2.82329624
93cellular amino acid biosynthetic process (GO:0008652)2.82144843
94ethanol oxidation (GO:0006069)2.81962050
95proline biosynthetic process (GO:0006561)2.81641229
96alpha-amino acid biosynthetic process (GO:1901607)2.80315423
97mannose metabolic process (GO:0006013)2.79736861
98acyl-CoA biosynthetic process (GO:0071616)2.78811721
99thioester biosynthetic process (GO:0035384)2.78811721
100monosaccharide biosynthetic process (GO:0046364)2.78312211
101carnitine metabolic process (GO:0009437)2.78266333
102fatty acid catabolic process (GO:0009062)2.77797658
103regulation of mitochondrial translation (GO:0070129)2.77233021
104fatty acid beta-oxidation (GO:0006635)2.77102296
105cholesterol efflux (GO:0033344)2.77044816
106positive regulation of triglyceride metabolic process (GO:0090208)2.77020556
107valine metabolic process (GO:0006573)2.76862154
108negative regulation of sterol transport (GO:0032372)2.76581723
109negative regulation of cholesterol transport (GO:0032375)2.76581723
1104-hydroxyproline metabolic process (GO:0019471)2.76480047
111positive regulation of triglyceride lipase activity (GO:0061365)2.76241009
112positive regulation of lipoprotein lipase activity (GO:0051006)2.76241009
113branched-chain amino acid metabolic process (GO:0009081)2.71817503
114high-density lipoprotein particle remodeling (GO:0034375)2.71563941
115nitrogen cycle metabolic process (GO:0071941)2.67518870
116negative regulation of fibrinolysis (GO:0051918)2.65100009
117ribosome assembly (GO:0042255)2.64862487
118protein carboxylation (GO:0018214)2.64366261
119peptidyl-glutamic acid carboxylation (GO:0017187)2.64366261
120glutamate metabolic process (GO:0006536)2.64006044
121protein targeting to mitochondrion (GO:0006626)2.63785350
122hexose biosynthetic process (GO:0019319)2.63061419
123proline metabolic process (GO:0006560)2.63027012
124C4-dicarboxylate transport (GO:0015740)2.62989960
125cellular metabolic compound salvage (GO:0043094)2.62922702
126base-excision repair, AP site formation (GO:0006285)2.62843534
127regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.62596719
128bile acid metabolic process (GO:0008206)2.62036972
129regulation of cholesterol metabolic process (GO:0090181)2.61559074
130short-chain fatty acid metabolic process (GO:0046459)2.61506785
131cofactor catabolic process (GO:0051187)2.58971487
132vitamin biosynthetic process (GO:0009110)2.57233691
133oligosaccharide catabolic process (GO:0009313)2.53547491
134rRNA modification (GO:0000154)2.53061340
135plasma lipoprotein particle assembly (GO:0034377)2.52802316
136protein complex biogenesis (GO:0070271)2.50679782
137very-low-density lipoprotein particle assembly (GO:0034379)2.49877258
138establishment of protein localization to mitochondrion (GO:0072655)2.49042471
139deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47049843
140mitochondrial respiratory chain complex assembly (GO:0033108)2.46731493
141plasma lipoprotein particle organization (GO:0071827)2.43479283
142aldehyde catabolic process (GO:0046185)2.39890815
143L-ascorbic acid metabolic process (GO:0019852)2.37093865
144protein-lipid complex assembly (GO:0065005)2.36356893
145GTP biosynthetic process (GO:0006183)2.35610636
146protein-lipid complex subunit organization (GO:0071825)2.35074084
147energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.30829665
148ATP hydrolysis coupled proton transport (GO:0015991)2.30829665
149fat-soluble vitamin biosynthetic process (GO:0042362)2.30793030
150acylglycerol homeostasis (GO:0055090)2.30001527
151triglyceride homeostasis (GO:0070328)2.30001527
152protein localization to mitochondrion (GO:0070585)2.29732111
153oxidative phosphorylation (GO:0006119)2.27968880
154regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.24972481
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.24584949
156rRNA methylation (GO:0031167)2.23932606
157pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.22527785
158UTP biosynthetic process (GO:0006228)2.22337454
159pentose metabolic process (GO:0019321)2.22028957
160inner mitochondrial membrane organization (GO:0007007)2.21232877

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.23052569
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.09387935
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.44427746
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32302042
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.18124150
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92668558
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78516386
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65118456
9ZNF263_19887448_ChIP-Seq_K562_Human2.58302218
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.47774145
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40542706
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34950343
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32482651
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32235216
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.24663270
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.14197212
17* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.09316299
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07032975
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85416548
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81318574
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80600745
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78208128
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77448760
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74612324
25NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74093544
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73987684
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.72214669
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.71826002
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.71816809
30SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.67292166
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.61524265
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.61104926
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59730284
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59726042
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59683300
36GABP_19822575_ChIP-Seq_HepG2_Human1.59519544
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58784167
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.57414634
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54596369
40* TET1_21451524_ChIP-Seq_MESCs_Mouse1.54480983
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50653562
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.50304215
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.49849037
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.48815096
45SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.48466496
46XRN2_22483619_ChIP-Seq_HELA_Human1.42566723
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42447417
48* LXR_22292898_ChIP-Seq_THP-1_Human1.42308585
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.39969159
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39636597
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37554074
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37347903
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35726753
54* P68_20966046_ChIP-Seq_HELA_Human1.34697774
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31593543
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26540834
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26418154
58FOXP1_21924763_ChIP-Seq_HESCs_Human1.25571474
59BCOR_27268052_Chip-Seq_Bcells_Human1.24919699
60* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24489757
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23807191
62CTCF_27219007_Chip-Seq_Bcells_Human1.23723393
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22576283
64SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21664640
65PHF8_20622854_ChIP-Seq_HELA_Human1.20566308
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19492848
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18668061
68NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18593334
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17984028
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17711400
71BCL6_27268052_Chip-Seq_Bcells_Human1.16576131
72* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16071022
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15538298
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15252835
75DCP1A_22483619_ChIP-Seq_HELA_Human1.14285215
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.13279355
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12436674
78DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09147540
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08754259
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08475535
81SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08364419
82CTCF_20526341_ChIP-Seq_ESCs_Human1.08203947
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07786303
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.07028926
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06440639
86VDR_23849224_ChIP-Seq_CD4+_Human1.06093798
87SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05336655
88TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05299257
89TTF2_22483619_ChIP-Seq_HELA_Human1.05223705
90POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04839207
91* E2F1_20622854_ChIP-Seq_HELA_Human1.04440555
92NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04251282
93AR_21909140_ChIP-Seq_LNCAP_Human1.04226647
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04045779
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03838776
96SA1_27219007_Chip-Seq_Bcells_Human1.03255588
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.03142091
98TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02480691
99CIITA_25753668_ChIP-Seq_RAJI_Human1.02360006
100GATA3_21867929_ChIP-Seq_CD8_Mouse1.02000666
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01787449
102RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00836784
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00591125
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.00068446
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.98994343
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97656300
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97294653
108RACK7_27058665_Chip-Seq_MCF-7_Human0.96539921
109* SMC4_20622854_ChIP-Seq_HELA_Human0.96464267
110SA1_27219007_Chip-Seq_ERYTHROID_Human0.96434755
111MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95965970
112GATA1_26923725_Chip-Seq_HPCs_Mouse0.95940733
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95061428
114RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94891050
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94311808
116* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93061773
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92760479
118KDM5A_27292631_Chip-Seq_BREAST_Human0.91723849
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91010559

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell5.96488965
2MP0002139_abnormal_hepatobiliary_system4.68860108
3MP0003806_abnormal_nucleotide_metabolis4.43919296
4MP0005360_urolithiasis3.89585465
5MP0005365_abnormal_bile_salt3.69762274
6MP0005085_abnormal_gallbladder_physiolo3.21658366
7MP0005670_abnormal_white_adipose3.09362341
8MP0003329_amyloid_beta_deposits3.07840437
9MP0005332_abnormal_amino_acid2.78790657
10MP0003878_abnormal_ear_physiology2.62367183
11MP0005377_hearing/vestibular/ear_phenot2.62367183
12MP0010329_abnormal_lipoprotein_level2.52375402
13MP0003879_abnormal_hair_cell2.47778251
14MP0003656_abnormal_erythrocyte_physiolo2.44887375
15MP0005058_abnormal_lysosome_morphology2.39197657
16MP0008260_abnormal_autophagy2.36661388
17MP0005083_abnormal_biliary_tract2.34218459
18MP0008875_abnormal_xenobiotic_pharmacok2.33466491
19MP0003123_paternal_imprinting2.31608622
20MP0000566_synostosis2.20379162
21MP0003646_muscle_fatigue2.08258668
22MP0003195_calcinosis2.07994429
23MP0006036_abnormal_mitochondrial_physio2.07888843
24MP0000604_amyloidosis2.02460315
25MP0003191_abnormal_cellular_cholesterol2.00193475
26MP0002837_dystrophic_cardiac_calcinosis1.89372315
27MP0002269_muscular_atrophy1.85544431
28MP0005410_abnormal_fertilization1.82086008
29MP0003122_maternal_imprinting1.80396512
30MP0006292_abnormal_olfactory_placode1.79201366
31MP0003011_delayed_dark_adaptation1.76973411
32MP0002118_abnormal_lipid_homeostasis1.74219172
33MP0005319_abnormal_enzyme/_coenzyme1.73893034
34MP0002254_reproductive_system_inflammat1.70363700
35MP0006035_abnormal_mitochondrial_morpho1.68128325
36MP0003693_abnormal_embryo_hatching1.64292563
37MP0004084_abnormal_cardiac_muscle1.63908111
38MP0004019_abnormal_vitamin_homeostasis1.62917542
39MP0000747_muscle_weakness1.59959638
40MP0001661_extended_life_span1.57579367
41MP0000609_abnormal_liver_physiology1.55621662
42MP0003941_abnormal_skin_development1.51409990
43MP0002653_abnormal_ependyma_morphology1.50827436
44MP0009697_abnormal_copulation1.48231062
45MP0001666_abnormal_nutrient_absorption1.44603730
46MP0003136_yellow_coat_color1.43465840
47MP0005646_abnormal_pituitary_gland1.43048373
48MP0003718_maternal_effect1.41768693
49MP0003111_abnormal_nucleus_morphology1.40491447
50MP0003186_abnormal_redox_activity1.39702202
51MP0004215_abnormal_myocardial_fiber1.37139968
52MP0004147_increased_porphyrin_level1.34236217
53MP0001764_abnormal_homeostasis1.33611640
54MP0001529_abnormal_vocalization1.30326570
55MP0002249_abnormal_larynx_morphology1.30042812
56MP0005584_abnormal_enzyme/coenzyme_acti1.28325891
57MP0009643_abnormal_urine_homeostasis1.27619049
58MP0005451_abnormal_body_composition1.27228342
59MP0005330_cardiomyopathy1.27058777
60MP0005666_abnormal_adipose_tissue1.23244707
61MP0000358_abnormal_cell_content/1.21510505
62MP0004233_abnormal_muscle_weight1.20962237
63MP0003172_abnormal_lysosome_physiology1.20428550
64MP0001293_anophthalmia1.18295407
65MP0004036_abnormal_muscle_relaxation1.17947352
66MP0002234_abnormal_pharynx_morphology1.14559932
67MP0003252_abnormal_bile_duct1.12305276
68MP0004130_abnormal_muscle_cell1.11354563
69MP0001756_abnormal_urination1.08685701
70MP0002909_abnormal_adrenal_gland1.05856191
71MP0003890_abnormal_embryonic-extraembry1.04719265
72MP0003868_abnormal_feces_composition1.04477423
73MP0002697_abnormal_eye_size1.02838676
74MP0000749_muscle_degeneration1.01943544
75MP0004043_abnormal_pH_regulation0.99256914
76MP0000049_abnormal_middle_ear0.98252466
77MP0001324_abnormal_eye_pigmentation0.96388340
78MP0000751_myopathy0.96076643
79MP0003221_abnormal_cardiomyocyte_apopto0.94865442
80MP0000750_abnormal_muscle_regeneration0.94214569
81MP0000598_abnormal_liver_morphology0.94131635
82MP0005408_hypopigmentation0.94025950
83MP0005266_abnormal_metabolism0.91259246
84MP0002089_abnormal_postnatal_growth/wei0.90313171
85MP0008932_abnormal_embryonic_tissue0.89745897
86MP0005375_adipose_tissue_phenotype0.89159519
87MP0000013_abnormal_adipose_tissue0.88834925
88MP0005636_abnormal_mineral_homeostasis0.87927044
89MP0004957_abnormal_blastocyst_morpholog0.87216823
90MP0009379_abnormal_foot_pigmentation0.85814875
91MP0001984_abnormal_olfaction0.84978343
92MP0002822_catalepsy0.84920896
93MP0009672_abnormal_birth_weight0.84694914
94MP0002098_abnormal_vibrissa_morphology0.83625533
95MP0002736_abnormal_nociception_after0.83094813
96MP0002938_white_spotting0.83074530
97MP0002078_abnormal_glucose_homeostasis0.82682453
98MP0004133_heterotaxia0.82419062
99MP0000678_abnormal_parathyroid_gland0.82389243
100MP0004270_analgesia0.81204238
101MP0003690_abnormal_glial_cell0.81055262
102MP0004145_abnormal_muscle_electrophysio0.78457544
103MP0000026_abnormal_inner_ear0.75686926
104MP0009046_muscle_twitch0.75392488
105MP0008775_abnormal_heart_ventricle0.75315045
106MP0001542_abnormal_bone_strength0.75156435
107MP0003283_abnormal_digestive_organ0.74833650
108MP0004742_abnormal_vestibular_system0.73330642
109* MP0003698_abnormal_male_reproductive0.72940491
110MP0003705_abnormal_hypodermis_morpholog0.72485014
111MP0002092_abnormal_eye_morphology0.72023752
112MP0005394_taste/olfaction_phenotype0.71448429
113MP0005499_abnormal_olfactory_system0.71448429
114MP0006276_abnormal_autonomic_nervous0.68804174
115MP0002971_abnormal_brown_adipose0.68386776
116MP0003119_abnormal_digestive_system0.68086208
117MP0000003_abnormal_adipose_tissue0.67879968
118MP0002796_impaired_skin_barrier0.67777451
119MP0003880_abnormal_central_pattern0.67142678
120* MP0003137_abnormal_impulse_conducting0.67011089
121MP0002970_abnormal_white_adipose0.66595132
122MP0004858_abnormal_nervous_system0.66404597
123MP0004142_abnormal_muscle_tone0.66278164
124MP0004185_abnormal_adipocyte_glucose0.65525810
125MP0005376_homeostasis/metabolism_phenot0.64105941
126MP0005395_other_phenotype0.64072999
127MP0002064_seizures0.64008530
128MP0008789_abnormal_olfactory_epithelium0.63911536
129MP0001730_embryonic_growth_arrest0.63602771
130MP0008058_abnormal_DNA_repair0.63478479
131MP0009642_abnormal_blood_homeostasis0.63275579
132MP0002229_neurodegeneration0.63149553
133MP0004087_abnormal_muscle_fiber0.62830938
134MP0003632_abnormal_nervous_system0.61662416
135MP0003634_abnormal_glial_cell0.61458583
136MP0004264_abnormal_extraembryonic_tissu0.61335299
137MP0002876_abnormal_thyroid_physiology0.61097270
138MP0001486_abnormal_startle_reflex0.60885163
139MP0001905_abnormal_dopamine_level0.60757934
140MP0001485_abnormal_pinna_reflex0.59729830
141MP0005535_abnormal_body_temperature0.59665016
142MP0000372_irregular_coat_pigmentation0.59414445
143MP0005220_abnormal_exocrine_pancreas0.58813101
144MP0010094_abnormal_chromosome_stability0.58552596
145MP0001929_abnormal_gametogenesis0.58487651
146MP0002090_abnormal_vision0.58085090
147MP0005334_abnormal_fat_pad0.56860184
148MP0002332_abnormal_exercise_endurance0.55744637
149MP0004885_abnormal_endolymph0.55450236
150MP0002161_abnormal_fertility/fecundity0.54450000
151MP0008872_abnormal_physiological_respon0.51824194
152MP0003953_abnormal_hormone_level0.50820055
153MP0010030_abnormal_orbit_morphology0.49928192
154MP0001544_abnormal_cardiovascular_syste0.48531327

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)4.77994775
2Hyperglycinemia (HP:0002154)4.62176765
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.48224059
4Abnormality of glycine metabolism (HP:0010895)4.46918379
5Abnormality of serine family amino acid metabolism (HP:0010894)4.46918379
6Xanthomatosis (HP:0000991)4.32390126
7Hyperlipoproteinemia (HP:0010980)4.20493912
8Ketosis (HP:0001946)3.78754890
9Hyperammonemia (HP:0001987)3.76154613
10Gout (HP:0001997)3.61262612
11Abnormal mitochondria in muscle tissue (HP:0008316)3.28484963
12Hypoglycemic coma (HP:0001325)3.27867629
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26485020
14Dicarboxylic aciduria (HP:0003215)3.26485020
15Abnormality of serum amino acid levels (HP:0003112)3.24635585
16Global brain atrophy (HP:0002283)3.24403947
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21592597
18Hypoalphalipoproteinemia (HP:0003233)3.19250683
19Intrahepatic cholestasis (HP:0001406)3.16650101
20Increased muscle lipid content (HP:0009058)3.15294502
21Acute encephalopathy (HP:0006846)3.14271726
22Lipid accumulation in hepatocytes (HP:0006561)3.13218472
23Acute necrotizing encephalopathy (HP:0006965)3.13152114
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.12347509
25Cerebral hypomyelination (HP:0006808)3.12221471
26Complement deficiency (HP:0004431)3.07104704
27Ketoacidosis (HP:0001993)3.04984191
28Retinal atrophy (HP:0001105)3.04504011
29Abnormality of fatty-acid metabolism (HP:0004359)3.01555849
30Mutism (HP:0002300)2.96539115
31Reduced antithrombin III activity (HP:0001976)2.93683078
32Generalized aminoaciduria (HP:0002909)2.93408715
33Deep venous thrombosis (HP:0002625)2.90438848
34Mitochondrial inheritance (HP:0001427)2.89541998
35Increased intramyocellular lipid droplets (HP:0012240)2.85198806
36Abnormality of alanine metabolism (HP:0010916)2.83286406
37Hyperalaninemia (HP:0003348)2.83286406
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83286406
39Hypolipoproteinemia (HP:0010981)2.75889665
40Lethargy (HP:0001254)2.70888876
41Increased CSF lactate (HP:0002490)2.70654293
42Renal Fanconi syndrome (HP:0001994)2.70570909
43Delusions (HP:0000746)2.70131607
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68872901
45Increased cerebral lipofuscin (HP:0011813)2.67214551
46Progressive muscle weakness (HP:0003323)2.65189208
47Neurofibrillary tangles (HP:0002185)2.61925837
48CNS demyelination (HP:0007305)2.61801311
49Glycosuria (HP:0003076)2.59961661
50Abnormality of urine glucose concentration (HP:0011016)2.59961661
51Increased hepatocellular lipid droplets (HP:0006565)2.57625251
52Irritability (HP:0000737)2.56749312
53Abnormality of sulfur amino acid metabolism (HP:0004339)2.55162080
54Hypobetalipoproteinemia (HP:0003563)2.52632880
55Vacuolated lymphocytes (HP:0001922)2.51913013
56Loss of speech (HP:0002371)2.42839001
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.42764252
58Abnormality of liposaccharide metabolism (HP:0010968)2.41987461
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.41987461
60Abnormality of glycolipid metabolism (HP:0010969)2.41987461
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41943556
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41943556
63Myoglobinuria (HP:0002913)2.41458030
64Respiratory failure (HP:0002878)2.40177043
65Hepatic necrosis (HP:0002605)2.40100383
66Abnormality of methionine metabolism (HP:0010901)2.39607115
67Abnormality of complement system (HP:0005339)2.38724244
68Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37462732
69Rhabdomyolysis (HP:0003201)2.37386919
70Broad distal phalanx of finger (HP:0009836)2.33905620
71Methylmalonic aciduria (HP:0012120)2.33523144
72Prolonged partial thromboplastin time (HP:0003645)2.32143893
73Athetosis (HP:0002305)2.28100639
74Cerebral inclusion bodies (HP:0100314)2.25962090
75Delayed CNS myelination (HP:0002188)2.24545632
76Type I transferrin isoform profile (HP:0003642)2.24496295
77Megaloblastic anemia (HP:0001889)2.22708145
78Brushfield spots (HP:0001088)2.22085235
79Ventricular fibrillation (HP:0001663)2.21966222
80Ragged-red muscle fibers (HP:0003200)2.20468521
81Progressive macrocephaly (HP:0004481)2.20384950
82Emotional lability (HP:0000712)2.19290361
83Atrioventricular block (HP:0001678)2.18730511
84Nuclear cataract (HP:0100018)2.15314187
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15040698
86Personality changes (HP:0000751)2.14795855
87Abnormality of the heme biosynthetic pathway (HP:0010472)2.14654153
88Microretrognathia (HP:0000308)2.14134276
89Myokymia (HP:0002411)2.12931141
90Lactic acidosis (HP:0003128)2.12448345
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.11646783
92Multiple enchondromatosis (HP:0005701)2.11256942
93Hypokinesia (HP:0002375)2.10912095
94Polyphagia (HP:0002591)2.09912065
95Late onset (HP:0003584)2.09318742
96Cerebral edema (HP:0002181)2.07891792
97Abnormality of glycolysis (HP:0004366)2.07047274
98Proximal tubulopathy (HP:0000114)2.05917735
99Testicular atrophy (HP:0000029)2.05328604
100Opisthotonus (HP:0002179)2.03914248
101Death in infancy (HP:0001522)2.02355416
102Tetraplegia (HP:0002445)2.01176254
103Hyperbilirubinemia (HP:0002904)1.99054353
104Vomiting (HP:0002013)1.98878979
105Diaphragmatic weakness (HP:0009113)1.98851846
106Abnormality of pyrimidine metabolism (HP:0004353)1.98711081
107Bundle branch block (HP:0011710)1.97039493
108Metabolic acidosis (HP:0001942)1.96918021
109Hyperphosphaturia (HP:0003109)1.96119903
110Reticulocytosis (HP:0001923)1.95562737
111Unsteady gait (HP:0002317)1.93607808
112Exercise intolerance (HP:0003546)1.92955778
113Prolonged neonatal jaundice (HP:0006579)1.92188315
114Abnormal gallbladder morphology (HP:0012437)1.92012167
115Abnormality of nucleobase metabolism (HP:0010932)1.92011462
116Hypercholesterolemia (HP:0003124)1.91447774
117Spastic paraparesis (HP:0002313)1.91381378
118Cholelithiasis (HP:0001081)1.91352735
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90364771
120Vaginal fistula (HP:0004320)1.89951309
121Hepatocellular necrosis (HP:0001404)1.89537877
122Abnormal gallbladder physiology (HP:0012438)1.89383288
123Cholecystitis (HP:0001082)1.89383288
124Spastic tetraparesis (HP:0001285)1.89346216
125Abnormality of purine metabolism (HP:0004352)1.88661653
126Abnormality of the Achilles tendon (HP:0005109)1.88060378
127Systemic lupus erythematosus (HP:0002725)1.88037096
128Abnormality of the umbilical cord (HP:0010881)1.88023133
129Choanal stenosis (HP:0000452)1.87250694
130Increased serum lactate (HP:0002151)1.87062310
131Abnormality of the intrinsic pathway (HP:0010989)1.86845262
132Nausea (HP:0002018)1.86239052
133Carpal bone hypoplasia (HP:0001498)1.85523143
134Glomerulonephritis (HP:0000099)1.85428922
135Hyperglycemia (HP:0003074)1.85174735
136Impulsivity (HP:0100710)1.84506981
137Breast hypoplasia (HP:0003187)1.84199029
138Increased serum pyruvate (HP:0003542)1.84025393
139Dysautonomia (HP:0002459)1.83854461
140Myopathic facies (HP:0002058)1.83826729
141Increased purine levels (HP:0004368)1.83187717
142Hyperuricemia (HP:0002149)1.83187717
143Skin nodule (HP:0200036)1.82749068
144Paraparesis (HP:0002385)1.80980772
145Disinhibition (HP:0000734)1.75360225
146Dysphonia (HP:0001618)1.74572409
147Abnormal urine phosphate concentration (HP:0012599)1.74138845
148Stridor (HP:0010307)1.74029534
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70527299
150Myoclonus (HP:0001336)1.68046129
151Achilles tendon contracture (HP:0001771)1.67615755
152Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.63688082
153Abnormal protein N-linked glycosylation (HP:0012347)1.63419654
154Abnormal glycosylation (HP:0012345)1.63419654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.02940277
2BUB14.14744735
3PDK33.19579787
4PDK43.19579787
5WEE13.07354098
6EPHA23.05070967
7NEK12.88770690
8TRIB32.65343208
9ERN12.21342321
10STK162.18182422
11EIF2AK12.17804860
12CSNK1G32.14424476
13VRK22.13131566
14AKT32.03246842
15PINK11.92237079
16TESK21.88920559
17PDK21.78697013
18NEK21.77701940
19PHKG11.77256982
20PHKG21.77256982
21CSNK1G21.76550566
22CDC71.70511640
23IRAK31.65197217
24PNCK1.63159253
25PBK1.62637972
26MAP3K111.61561761
27NME21.61363804
28CSNK1A1L1.60221095
29CSNK1G11.59586191
30ICK1.59020336
31TESK11.58423381
32TSSK61.52560007
33SCYL21.50909739
34BRAF1.48274801
35TRIM281.47463073
36PLK41.41897515
37ARAF1.41885989
38PAK61.40844143
39TTK1.40099898
40LATS11.40096188
41MAPK151.39493946
42PRKD31.37407154
43LMTK21.36591225
44MAP3K91.34761377
45EPHB21.28053462
46DDR21.23772119
47PIM21.21711269
48EIF2AK31.19137834
49DYRK31.18796446
50CCNB11.07455882
51WNK31.03378350
52KDR1.03045175
53MUSK0.99781118
54SIK10.97418839
55MST1R0.96493809
56NTRK10.91361177
57SMG10.89975506
58ACVR1B0.89650533
59MAP3K80.83391785
60AURKA0.83090805
61MAP2K20.81283409
62BRSK10.80285933
63DMPK0.78731057
64FGFR40.78028958
65STK390.77096853
66CAMK2D0.74780636
67PRKCG0.74141919
68MAP2K70.73517699
69KSR20.72858715
70PAK10.71259019
71DAPK10.70950262
72CSNK1A10.66676467
73CAMK2G0.65414061
74PLK10.64026814
75STK380.60879550
76PRKCZ0.60126893
77DAPK30.59475070
78CAMKK20.58319514
79CAMK1D0.57928085
80TYRO30.57491116
81ILK0.57278790
82MAPK120.56770985
83CDK70.56535846
84PDPK10.56027564
85LATS20.55561629
86CSNK2A10.55489830
87PAK40.54157135
88GRK60.54049441
89DYRK20.53680377
90PRKAA10.53481671
91PRKCI0.52482266
92DAPK20.52143954
93CAMK2B0.51980747
94MAP2K10.51864866
95ABL20.51648837
96ZAK0.50514928
97WNK40.50315617
98BMX0.50287946
99OXSR10.50172537
100MST40.48607315
101MTOR0.48089013
102RPS6KA20.48030469
103CDK150.47535785
104PKN20.47105582
105PLK30.47077781
106BRSK20.46847820
107ADRBK20.45915102
108CDK140.45730792
109MAP2K30.45519137
110MAP2K60.45444868
111TAOK20.44663309
112CDK11A0.43699793
113PRKG20.43271420
114OBSCN0.43131901
115TTN0.42981321
116CDK180.41822989
117PTK20.41229422
118PAK30.40741527
119TLK10.39511673
120CSNK1E0.38724951
121MAP4K20.38697021
122CSNK2A20.38614578
123LIMK10.38483240
124FLT30.37722237
125MAP2K40.37676278
126MAPK110.36284045
127CDK10.36224392
128NME10.35831179
129MAPKAPK30.34669438
130MINK10.34657522
131IRAK20.33966813
132PRKACG0.33953403
133AKT20.33585775
134MET0.33353946
135MARK10.32030470
136EPHA40.31096954
137RPS6KB20.30861037
138BLK0.30426491
139CDK190.28562597
140GRK50.27798543
141PAK20.27582864
142CAMKK10.26812533
143CHEK20.25786915

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.95631904
2Vitamin B6 metabolism_Homo sapiens_hsa007502.95319845
3Folate biosynthesis_Homo sapiens_hsa007902.84618628
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82586608
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.78443596
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67791223
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52284852
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.43235052
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.26633394
10Fatty acid degradation_Homo sapiens_hsa000712.22774135
11Nitrogen metabolism_Homo sapiens_hsa009102.21947776
12Biosynthesis of amino acids_Homo sapiens_hsa012302.19456310
13Carbon metabolism_Homo sapiens_hsa012002.16939415
14Propanoate metabolism_Homo sapiens_hsa006402.14777495
15Sulfur relay system_Homo sapiens_hsa041221.98007196
16Fatty acid metabolism_Homo sapiens_hsa012121.93641124
17Proteasome_Homo sapiens_hsa030501.91062860
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.86951614
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86907573
20Pyruvate metabolism_Homo sapiens_hsa006201.84853224
21Arginine biosynthesis_Homo sapiens_hsa002201.84457064
22Pentose phosphate pathway_Homo sapiens_hsa000301.80283393
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.78544481
24Selenocompound metabolism_Homo sapiens_hsa004501.77943866
25Butanoate metabolism_Homo sapiens_hsa006501.74650970
26Peroxisome_Homo sapiens_hsa041461.66517755
27Fructose and mannose metabolism_Homo sapiens_hsa000511.63215776
28PPAR signaling pathway_Homo sapiens_hsa033201.47699195
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.47391745
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46129113
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.43107551
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.41081411
33Tryptophan metabolism_Homo sapiens_hsa003801.40045210
34Ribosome_Homo sapiens_hsa030101.39642041
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39461927
36Regulation of autophagy_Homo sapiens_hsa041401.39092532
37Collecting duct acid secretion_Homo sapiens_hsa049661.31197451
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.29925887
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26060594
40Fatty acid elongation_Homo sapiens_hsa000621.18401921
41Complement and coagulation cascades_Homo sapiens_hsa046101.16326636
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.15992305
43Vibrio cholerae infection_Homo sapiens_hsa051101.15053130
44beta-Alanine metabolism_Homo sapiens_hsa004101.14334581
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13546260
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11817808
47Arginine and proline metabolism_Homo sapiens_hsa003301.10817146
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08922555
49Glycerolipid metabolism_Homo sapiens_hsa005611.03947785
50Fat digestion and absorption_Homo sapiens_hsa049751.03409301
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02946245
52Fatty acid biosynthesis_Homo sapiens_hsa000611.02628871
53Homologous recombination_Homo sapiens_hsa034401.01151909
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95169833
55Bile secretion_Homo sapiens_hsa049760.93438251
56Glutathione metabolism_Homo sapiens_hsa004800.88832129
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86032369
58Lysosome_Homo sapiens_hsa041420.85668389
59Galactose metabolism_Homo sapiens_hsa000520.85660151
60DNA replication_Homo sapiens_hsa030300.84968788
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84813236
62Metabolic pathways_Homo sapiens_hsa011000.83955813
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81325948
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80995533
65Pyrimidine metabolism_Homo sapiens_hsa002400.80247717
66Vitamin digestion and absorption_Homo sapiens_hsa049770.78844685
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78530101
68Steroid biosynthesis_Homo sapiens_hsa001000.77723123
69Sphingolipid metabolism_Homo sapiens_hsa006000.77436610
70Phenylalanine metabolism_Homo sapiens_hsa003600.77155121
71ABC transporters_Homo sapiens_hsa020100.75018507
72N-Glycan biosynthesis_Homo sapiens_hsa005100.74720445
73Oxidative phosphorylation_Homo sapiens_hsa001900.72677827
74Histidine metabolism_Homo sapiens_hsa003400.72446756
75One carbon pool by folate_Homo sapiens_hsa006700.71090013
76Other glycan degradation_Homo sapiens_hsa005110.70895393
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.69699224
78Parkinsons disease_Homo sapiens_hsa050120.66938512
79Chemical carcinogenesis_Homo sapiens_hsa052040.66500614
80RNA polymerase_Homo sapiens_hsa030200.66250896
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65941836
82Starch and sucrose metabolism_Homo sapiens_hsa005000.65589146
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.64911319
84Fanconi anemia pathway_Homo sapiens_hsa034600.64519256
85Cardiac muscle contraction_Homo sapiens_hsa042600.63706919
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61403487
87Staphylococcus aureus infection_Homo sapiens_hsa051500.59389160
88Tyrosine metabolism_Homo sapiens_hsa003500.58463242
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56074475
90Prion diseases_Homo sapiens_hsa050200.54086875
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.53139114
92Retinol metabolism_Homo sapiens_hsa008300.51679528
93Nucleotide excision repair_Homo sapiens_hsa034200.50760075
94Sulfur metabolism_Homo sapiens_hsa009200.47953507
95Base excision repair_Homo sapiens_hsa034100.47833418
96Caffeine metabolism_Homo sapiens_hsa002320.46914598
97Mineral absorption_Homo sapiens_hsa049780.46736480
98RNA transport_Homo sapiens_hsa030130.46660316
99Huntingtons disease_Homo sapiens_hsa050160.46421470
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44738015
101Synaptic vesicle cycle_Homo sapiens_hsa047210.42054021
102Purine metabolism_Homo sapiens_hsa002300.41582028
103Protein export_Homo sapiens_hsa030600.39268034
104Glucagon signaling pathway_Homo sapiens_hsa049220.38417856
105AMPK signaling pathway_Homo sapiens_hsa041520.37845579
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37833913
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.37679873
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37342336
109Mismatch repair_Homo sapiens_hsa034300.31789640
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.31567665
111Arachidonic acid metabolism_Homo sapiens_hsa005900.29865649
112Renin-angiotensin system_Homo sapiens_hsa046140.29621589
113Alzheimers disease_Homo sapiens_hsa050100.29176001
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28206481
115Spliceosome_Homo sapiens_hsa030400.25554458
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24787535

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