SLC2A9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.22917853
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.22917853
3L-phenylalanine metabolic process (GO:0006558)6.92315656
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.92315656
5aromatic amino acid family catabolic process (GO:0009074)6.56464374
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.39795786
7tryptophan catabolic process (GO:0006569)5.97163606
8indole-containing compound catabolic process (GO:0042436)5.97163606
9indolalkylamine catabolic process (GO:0046218)5.97163606
10kynurenine metabolic process (GO:0070189)5.86875808
11bile acid biosynthetic process (GO:0006699)5.75360041
12alpha-linolenic acid metabolic process (GO:0036109)5.74196929
13tryptophan metabolic process (GO:0006568)5.62479399
14urea metabolic process (GO:0019627)5.60015749
15urea cycle (GO:0000050)5.60015749
16high-density lipoprotein particle remodeling (GO:0034375)5.53342738
17glyoxylate metabolic process (GO:0046487)5.49266934
18negative regulation of fibrinolysis (GO:0051918)5.45904189
19protein carboxylation (GO:0018214)5.33150632
20peptidyl-glutamic acid carboxylation (GO:0017187)5.33150632
21regulation of fibrinolysis (GO:0051917)5.21044233
22cysteine metabolic process (GO:0006534)5.17189545
23hemidesmosome assembly (GO:0031581)5.15381134
24nitrogen cycle metabolic process (GO:0071941)5.12340357
25complement activation, alternative pathway (GO:0006957)5.11273444
26sulfur amino acid catabolic process (GO:0000098)5.07814065
27regulation of protein activation cascade (GO:2000257)5.06414158
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02207563
29bile acid metabolic process (GO:0008206)4.97813423
30regulation of cholesterol esterification (GO:0010872)4.93126743
31serine family amino acid catabolic process (GO:0009071)4.90603868
32regulation of triglyceride catabolic process (GO:0010896)4.87062425
33reverse cholesterol transport (GO:0043691)4.83762521
34plasma lipoprotein particle remodeling (GO:0034369)4.75317854
35protein-lipid complex remodeling (GO:0034368)4.75317854
36macromolecular complex remodeling (GO:0034367)4.75317854
37aromatic amino acid family metabolic process (GO:0009072)4.74169069
38phospholipid efflux (GO:0033700)4.73429998
39regulation of complement activation (GO:0030449)4.72605099
40negative regulation of sterol transport (GO:0032372)4.72372741
41negative regulation of cholesterol transport (GO:0032375)4.72372741
42homocysteine metabolic process (GO:0050667)4.63507197
43tyrosine metabolic process (GO:0006570)4.55809281
44lysine catabolic process (GO:0006554)4.52880589
45lysine metabolic process (GO:0006553)4.52880589
46triglyceride homeostasis (GO:0070328)4.52624650
47acylglycerol homeostasis (GO:0055090)4.52624650
48amino-acid betaine metabolic process (GO:0006577)4.50707571
49plasma lipoprotein particle clearance (GO:0034381)4.46859820
50alpha-amino acid catabolic process (GO:1901606)4.42905274
51bile acid and bile salt transport (GO:0015721)4.37048914
52regulation of hypersensitivity (GO:0002883)4.34021488
53cholesterol efflux (GO:0033344)4.30970841
54cellular ketone body metabolic process (GO:0046950)4.28939191
55response to peptidoglycan (GO:0032494)4.27810747
56cellular glucuronidation (GO:0052695)4.24151480
57neutrophil activation involved in immune response (GO:0002283)4.23741197
58glycine metabolic process (GO:0006544)4.22989844
59indolalkylamine metabolic process (GO:0006586)4.19878380
60plasma lipoprotein particle assembly (GO:0034377)4.16353897
61imidazole-containing compound metabolic process (GO:0052803)4.15683808
62drug catabolic process (GO:0042737)4.15377386
63amine catabolic process (GO:0009310)4.09847116
64cellular biogenic amine catabolic process (GO:0042402)4.09847116
65cellular amino acid catabolic process (GO:0009063)4.06571341
66glutamate metabolic process (GO:0006536)4.05584641
67ethanol oxidation (GO:0006069)4.03848549
68coenzyme catabolic process (GO:0009109)4.03468619
69benzene-containing compound metabolic process (GO:0042537)4.02605290
70serine family amino acid metabolic process (GO:0009069)4.00313929
71cellular modified amino acid catabolic process (GO:0042219)3.93647320
72low-density lipoprotein particle remodeling (GO:0034374)3.93364693
73dicarboxylic acid biosynthetic process (GO:0043650)3.91388472
74positive regulation of lipoprotein lipase activity (GO:0051006)3.91121457
75positive regulation of triglyceride lipase activity (GO:0061365)3.91121457
76fibrinolysis (GO:0042730)3.90336212
77very-low-density lipoprotein particle assembly (GO:0034379)3.85850120
78serine family amino acid biosynthetic process (GO:0009070)3.84411895
79arginine metabolic process (GO:0006525)3.83703489
80positive regulation of lipid catabolic process (GO:0050996)3.82688813
81phospholipid homeostasis (GO:0055091)3.82598005
82aldehyde catabolic process (GO:0046185)3.80333093
83cholesterol homeostasis (GO:0042632)3.78818130
84protein-lipid complex assembly (GO:0065005)3.78290435
85glucuronate metabolic process (GO:0019585)3.76398013
86uronic acid metabolic process (GO:0006063)3.76398013
87intestinal cholesterol absorption (GO:0030299)3.73361633
88sterol homeostasis (GO:0055092)3.73206011
89regulation of cholesterol homeostasis (GO:2000188)3.72875534
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.72801316
91detection of molecule of bacterial origin (GO:0032490)3.70206282
92ketone body metabolic process (GO:1902224)3.70163830
93negative regulation of lipase activity (GO:0060192)3.68990261
94plasma lipoprotein particle organization (GO:0071827)3.68311892
95oligosaccharide catabolic process (GO:0009313)3.67283408
96regulation of bile acid biosynthetic process (GO:0070857)3.67137826
97blood coagulation, intrinsic pathway (GO:0007597)3.64093104
98complement activation, classical pathway (GO:0006958)3.63851487
99pinocytosis (GO:0006907)3.62657188
100flavonoid metabolic process (GO:0009812)3.61843760
101complement activation (GO:0006956)3.61124624
102glycosphingolipid catabolic process (GO:0046479)3.60683627
103organic acid catabolic process (GO:0016054)3.59274131
104carboxylic acid catabolic process (GO:0046395)3.59274131
105cofactor catabolic process (GO:0051187)3.59174173
106short-chain fatty acid metabolic process (GO:0046459)3.58870019
107protein activation cascade (GO:0072376)3.58304159
108lipoprotein metabolic process (GO:0042157)3.56353145
109acetyl-CoA metabolic process (GO:0006084)3.54702717
110immunoglobulin mediated immune response (GO:0016064)3.49491255
111detection of other organism (GO:0098543)3.41111304
112detection of external biotic stimulus (GO:0098581)3.33509838
113negative regulation of interleukin-12 production (GO:0032695)3.33190405
114macrophage activation involved in immune response (GO:0002281)3.22483107
115regulation of myeloid leukocyte mediated immunity (GO:0002886)3.22425413
116glycolipid catabolic process (GO:0019377)3.21082115
117detection of bacterium (GO:0016045)3.19219952
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15128712
119positive regulation by organism of defense response of other organism involved in symbiotic interact3.15128712
120modulation by symbiont of host immune response (GO:0052553)3.15128712
121positive regulation by symbiont of host defense response (GO:0052509)3.15128712
122modulation by symbiont of host defense response (GO:0052031)3.15128712
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15128712
124regulation of macrophage chemotaxis (GO:0010758)3.09921432
125cellular extravasation (GO:0045123)3.07829850
126regulation of mast cell degranulation (GO:0043304)3.06655861
127lipopolysaccharide-mediated signaling pathway (GO:0031663)3.02783747
128ceramide catabolic process (GO:0046514)3.01161196
129regulation of apoptotic cell clearance (GO:2000425)2.99221636
130detection of biotic stimulus (GO:0009595)2.95782902
131positive regulation of mast cell degranulation (GO:0043306)2.92900932
132positive regulation of mast cell activation involved in immune response (GO:0033008)2.92900932
133positive regulation of hemostasis (GO:1900048)2.91299242
134positive regulation of blood coagulation (GO:0030194)2.91299242
135negative regulation of protein activation cascade (GO:2000258)2.90351668
136regulation of mast cell activation involved in immune response (GO:0033006)2.89385719
137positive regulation of leukocyte degranulation (GO:0043302)2.88868063
138response to muramyl dipeptide (GO:0032495)2.88232006
139regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.86770313
140positive regulation of mast cell activation (GO:0033005)2.85799407
141positive regulation of phagocytosis (GO:0050766)2.84998948
142positive regulation of coagulation (GO:0050820)2.83044574
143regulation of leukocyte degranulation (GO:0043300)2.82137452
144positive regulation of gamma-delta T cell activation (GO:0046645)2.81382538
145positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80786991
146positive regulation of chemokine secretion (GO:0090197)2.79124508
147cellular response to thyroid hormone stimulus (GO:0097067)2.77571301
148positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.75058533
149protein-lipid complex subunit organization (GO:0071825)2.75020257
150negative regulation of complement activation (GO:0045916)2.71008594
151negative regulation of myeloid cell apoptotic process (GO:0033033)2.70783271
152regulation of T-helper 2 cell differentiation (GO:0045628)2.69811128
153acute-phase response (GO:0006953)2.69607174
154positive regulation of fatty acid biosynthetic process (GO:0045723)2.64764629
155regulation of cholesterol storage (GO:0010885)2.62479125
156response to thyroid hormone (GO:0097066)2.62396818
157granulocyte activation (GO:0036230)2.61403469
158regulation of mast cell activation (GO:0033003)2.59103520
159positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58924003
160regulation of chemokine secretion (GO:0090196)2.58828572
161B cell mediated immunity (GO:0019724)2.58290717
162negative regulation of cytokine production involved in immune response (GO:0002719)2.57664965
163regulation of phagocytosis (GO:0050764)2.54368533
164regulation of vitamin D biosynthetic process (GO:0060556)2.52617224
165positive regulation of cellular amide metabolic process (GO:0034250)2.52517666
166myeloid cell activation involved in immune response (GO:0002275)2.51647087
167interferon-gamma-mediated signaling pathway (GO:0060333)2.51634006
168regulation of superoxide anion generation (GO:0032928)2.51446807
169low-density lipoprotein particle clearance (GO:0034383)2.51442043
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.51379402
171positive regulation of type 2 immune response (GO:0002830)2.51320557

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.15025166
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.05342567
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.77171716
4TP63_17297297_ChIP-ChIP_HaCaT_Human6.54510839
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.36914705
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97069365
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89849290
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73472523
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.96199045
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.86998928
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.59981690
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34310981
13VDR_24763502_ChIP-Seq_THP-1_Human2.11282030
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05960974
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04246562
16VDR_24787735_ChIP-Seq_THP-1_Human2.00792143
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4765780
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99136965
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93499740
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89463279
21SPI1_23127762_ChIP-Seq_K562_Human1.86175788
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84312041
23VDR_21846776_ChIP-Seq_THP-1_Human1.78478072
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73804873
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.69826586
26CLOCK_20551151_ChIP-Seq_293T_Human1.67208570
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.64383872
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.63891008
29SPI1_23547873_ChIP-Seq_NB4_Human1.63682721
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59929283
31GATA1_22025678_ChIP-Seq_K562_Human1.59249443
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57422803
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54767136
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54595116
35P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52087679
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49396124
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40975941
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38278053
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34367418
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33600810
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.32858666
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30815250
43HTT_18923047_ChIP-ChIP_STHdh_Human1.30609943
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29573069
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27946531
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27394363
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21911318
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21911318
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.20487878
50RUNX_20019798_ChIP-Seq_JUKART_Human1.19362702
51RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13821365
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.13261651
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10993165
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10334596
55PU_27001747_Chip-Seq_BMDM_Mouse1.09817627
56MAF_26560356_Chip-Seq_TH1_Human1.08124888
57SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07772821
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05429519
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04821779
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04578907
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04292171
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04164229
63MYB_26560356_Chip-Seq_TH2_Human1.01751513
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01523794
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.00074490
66* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99321770
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98336689
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98098476
69SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98096370
70KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97276573
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97025746
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96891882
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96720261
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96593362
75* GATA4_25053715_ChIP-Seq_YYC3_Human0.95683495
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95676119
77TCF7_22412390_ChIP-Seq_EML_Mouse0.95539688
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94582208
79MYB_26560356_Chip-Seq_TH1_Human0.94465005
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93003747
81RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92062265
82GATA3_27048872_Chip-Seq_THYMUS_Human0.91000076
83* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90635836
84* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89361723
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87294530
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86539138
87* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85796379
88UBF1/2_26484160_Chip-Seq_HMECs_Human0.85530794
89ESR2_21235772_ChIP-Seq_MCF-7_Human0.78720863
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78311602
91* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77954030
92ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77804459
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76157941
94IRF8_27001747_Chip-Seq_BMDM_Mouse0.73994925
95BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73613122
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73586602
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72595002
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.72135956
99SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70420398
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69593792
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69005373
102CDX2_20551321_ChIP-Seq_CACO-2_Human0.68230040
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.67576739
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67458789
105* LXR_22292898_ChIP-Seq_THP-1_Human0.65562604
106* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.64254977
107GATA2_19941826_ChIP-Seq_K562_Human0.63195669
108FOXO3_23340844_ChIP-Seq_DLD1_Human0.62851162
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61131389
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.60871301
111BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60446042
112GATA6_25053715_ChIP-Seq_YYC3_Human0.60445981
113CEBPB_22108803_ChIP-Seq_LS180_Human0.59958233
114* GATA1_19941827_ChIP-Seq_MEL_Mouse0.59946307
115ZNF263_19887448_ChIP-Seq_K562_Human0.59626149
116GATA1_19941826_ChIP-Seq_K562_Human0.58296225
117EGR1_19032775_ChIP-ChIP_M12_Human0.58052307
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.57639190
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57409336
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.57400425
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55637037
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55637037
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53841430
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.53819959
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53033464
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52395620
127* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52243776
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52175202
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.50686965
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.50361660
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.49800542
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.49665668
133IRF8_21731497_ChIP-ChIP_J774_Mouse0.48148267
134AR_20517297_ChIP-Seq_VCAP_Human0.47959908
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47753726
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46757275
137MYC_19915707_ChIP-ChIP_AK7_Human0.45824032
138* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.44952462
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.44791861
140* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.44503444
141SCL_19346495_ChIP-Seq_HPC-7_Human0.44176803
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.44143872
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.43904761
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43565077
145CBP_21632823_ChIP-Seq_H3396_Human0.43431173
146P53_21459846_ChIP-Seq_SAOS-2_Human0.42904689
147SOX2_20726797_ChIP-Seq_SW620_Human0.42609393
148* STAT1_17558387_ChIP-Seq_HELA_Human0.42567937
149CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.42292882
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.42064008
151* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.41022025
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.40021419
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.39804856
154RACK7_27058665_Chip-Seq_MCF-7_Human0.39300094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12538021
2* MP0005360_urolithiasis7.08859510
3MP0005085_abnormal_gallbladder_physiolo6.23232421
4MP0005365_abnormal_bile_salt5.95608921
5MP0008875_abnormal_xenobiotic_pharmacok5.05221898
6MP0003806_abnormal_nucleotide_metabolis3.95224028
7MP0003252_abnormal_bile_duct3.87168318
8MP0010329_abnormal_lipoprotein_level3.55488650
9MP0009840_abnormal_foam_cell3.44217107
10MP0005083_abnormal_biliary_tract2.97023512
11MP0003172_abnormal_lysosome_physiology2.80323679
12MP0003195_calcinosis2.78386351
13MP0001666_abnormal_nutrient_absorption2.71902320
14MP0001835_abnormal_antigen_presentation2.69077206
15* MP0005332_abnormal_amino_acid2.58708260
16MP0003191_abnormal_cellular_cholesterol2.39153895
17MP0002148_abnormal_hypersensitivity_rea2.34647958
18MP0000609_abnormal_liver_physiology2.21554849
19MP0004019_abnormal_vitamin_homeostasis2.16865731
20MP0002118_abnormal_lipid_homeostasis2.07596832
21MP0005000_abnormal_immune_tolerance1.97123841
22MP0005387_immune_system_phenotype1.93398470
23MP0001790_abnormal_immune_system1.93398470
24MP0002138_abnormal_hepatobiliary_system1.92183854
25MP0006054_spinal_hemorrhage1.86412910
26MP0005319_abnormal_enzyme/_coenzyme1.83488861
27MP0003183_abnormal_peptide_metabolism1.82188535
28MP0000579_abnormal_nail_morphology1.80925793
29MP0003868_abnormal_feces_composition1.77654045
30MP0002452_abnormal_antigen_presenting1.72451325
31MP0008260_abnormal_autophagy1.72161314
32MP0001800_abnormal_humoral_immune1.69408011
33MP0001764_abnormal_homeostasis1.65730717
34MP0002723_abnormal_immune_serum1.63706942
35MP0009278_abnormal_bone_marrow1.63566442
36MP0005397_hematopoietic_system_phenotyp1.59050628
37MP0001545_abnormal_hematopoietic_system1.59050628
38MP0005671_abnormal_response_to1.56030645
39MP0005584_abnormal_enzyme/coenzyme_acti1.55905223
40MP0000858_altered_metastatic_potential1.51855283
41MP0009697_abnormal_copulation1.46594017
42MP0005451_abnormal_body_composition1.42421665
43MP0002420_abnormal_adaptive_immunity1.39393654
44MP0001819_abnormal_immune_cell1.39301273
45MP0005164_abnormal_response_to1.35635441
46MP0010155_abnormal_intestine_physiology1.35354384
47MP0003705_abnormal_hypodermis_morpholog1.34823272
48MP0003656_abnormal_erythrocyte_physiolo1.34502794
49MP0002998_abnormal_bone_remodeling1.33630038
50MP0004381_abnormal_hair_follicle1.32843513
51MP0002132_abnormal_respiratory_system1.30504843
52MP0009333_abnormal_splenocyte_physiolog1.29537825
53MP0003566_abnormal_cell_adhesion1.28322341
54* MP0009643_abnormal_urine_homeostasis1.27740832
55MP0003011_delayed_dark_adaptation1.26777337
56MP0001849_ear_inflammation1.23096854
57MP0000598_abnormal_liver_morphology1.22191360
58MP0000343_altered_response_to1.20720020
59MP0003828_pulmonary_edema1.18476375
60MP0002405_respiratory_system_inflammati1.18317422
61MP0008004_abnormal_stomach_pH1.15224774
62MP0003186_abnormal_redox_activity1.15081910
63MP0000604_amyloidosis1.14426037
64MP0009764_decreased_sensitivity_to1.14092949
65MP0001851_eye_inflammation1.13433391
66MP0001216_abnormal_epidermal_layer1.13061997
67MP0009763_increased_sensitivity_to1.09560136
68MP0002254_reproductive_system_inflammat1.08648340
69MP0008469_abnormal_protein_level1.05271920
70MP0005647_abnormal_sex_gland1.01944551
71MP0005167_abnormal_blood-brain_barrier1.01525108
72MP0000716_abnormal_immune_system0.98165317
73MP0005409_darkened_coat_color0.94834423
74MP0003448_altered_tumor_morphology0.91869837
75MP0005310_abnormal_salivary_gland0.91427676
76MP0003950_abnormal_plasma_membrane0.91324769
77* MP0009642_abnormal_blood_homeostasis0.89222118
78MP0001915_intracranial_hemorrhage0.88150725
79MP0002060_abnormal_skin_morphology0.87878664
80MP0005408_hypopigmentation0.87126782
81* MP0005636_abnormal_mineral_homeostasis0.86744817
82MP0010368_abnormal_lymphatic_system0.85812173
83MP0005464_abnormal_platelet_physiology0.85619945
84MP0003436_decreased_susceptibility_to0.83809380
85MP0009765_abnormal_xenobiotic_induced0.80398646
86MP0000920_abnormal_myelination0.79773232
87MP0000465_gastrointestinal_hemorrhage0.78242738
88MP0005376_homeostasis/metabolism_phenot0.76429077
89MP0002078_abnormal_glucose_homeostasis0.75574994
90MP0002398_abnormal_bone_marrow0.75417728
91MP0002429_abnormal_blood_cell0.75204728
92MP0005084_abnormal_gallbladder_morpholo0.74228584
93MP0005670_abnormal_white_adipose0.74039372
94MP0002971_abnormal_brown_adipose0.73724156
95MP0004130_abnormal_muscle_cell0.73085342
96MP0006036_abnormal_mitochondrial_physio0.70678338
97MP0000467_abnormal_esophagus_morphology0.70625074
98MP0005334_abnormal_fat_pad0.70208357
99MP0000689_abnormal_spleen_morphology0.70172706
100MP0002796_impaired_skin_barrier0.70016717
101MP0003300_gastrointestinal_ulcer0.69958672
102MP0003091_abnormal_cell_migration0.69872630
103MP0010678_abnormal_skin_adnexa0.69300804
104MP0005220_abnormal_exocrine_pancreas0.68431064
105MP0000678_abnormal_parathyroid_gland0.68101698
106MP0003690_abnormal_glial_cell0.66187969
107MP0006082_CNS_inflammation0.64126394
108MP0001881_abnormal_mammary_gland0.63233638
109MP0009053_abnormal_anal_canal0.62303693
110MP0002876_abnormal_thyroid_physiology0.61347968
111MP0005058_abnormal_lysosome_morphology0.61098189
112MP0003724_increased_susceptibility_to0.60215445
113MP0001661_extended_life_span0.57610701
114MP0005266_abnormal_metabolism0.57360254
115MP0005535_abnormal_body_temperature0.56818532
116* MP0002136_abnormal_kidney_physiology0.56793000
117MP0000639_abnormal_adrenal_gland0.56240823
118MP0005448_abnormal_energy_balance0.55585929
119MP0002928_abnormal_bile_duct0.51139193
120MP0008873_increased_physiological_sensi0.50719001
121MP0005395_other_phenotype0.50531262
122* MP0001845_abnormal_inflammatory_respons0.50335490
123* MP0001756_abnormal_urination0.49741414
124MP0003329_amyloid_beta_deposits0.49622101
125MP0003075_altered_response_to0.49372086
126MP0001853_heart_inflammation0.49317536
127MP0005166_decreased_susceptibility_to0.48901402
128MP0004782_abnormal_surfactant_physiolog0.46787650
129MP0003638_abnormal_response/metabolism_0.46594408
130MP0008874_decreased_physiological_sensi0.45533400
131MP0004947_skin_inflammation0.45349707
132MP0003718_maternal_effect0.44681847
133MP0003303_peritoneal_inflammation0.43036941
134MP0000249_abnormal_blood_vessel0.41916241
135MP0006035_abnormal_mitochondrial_morpho0.41703958
136MP0002419_abnormal_innate_immunity0.41565620
137MP0009115_abnormal_fat_cell0.40943002
138MP0005666_abnormal_adipose_tissue0.39695339
139MP0005025_abnormal_response_to0.38910807
140MP0000685_abnormal_immune_system0.38117242
141MP0002168_other_aberrant_phenotype0.36835018
142MP0010234_abnormal_vibrissa_follicle0.36448811
143MP0001243_abnormal_dermal_layer0.36409031
144MP0009785_altered_susceptibility_to0.36390061
145MP0003953_abnormal_hormone_level0.36020392
146MP0004264_abnormal_extraembryonic_tissu0.34689105
147MP0005023_abnormal_wound_healing0.34201600
148MP0002970_abnormal_white_adipose0.34138934
149MP0003453_abnormal_keratinocyte_physiol0.34067211
150MP0009384_cardiac_valve_regurgitation0.33054059
151MP0004883_abnormal_blood_vessel0.32846027
152MP0001533_abnormal_skeleton_physiology0.31110375

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.29307085
2Intrahepatic cholestasis (HP:0001406)7.09595457
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.03278415
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.46054842
5Hypobetalipoproteinemia (HP:0003563)6.36645825
6Prolonged partial thromboplastin time (HP:0003645)6.25936726
7Xanthomatosis (HP:0000991)6.18214143
8Hyperlipoproteinemia (HP:0010980)5.29638697
9Complement deficiency (HP:0004431)5.19427073
10Abnormality of liposaccharide metabolism (HP:0010968)4.92328904
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.92328904
12Abnormality of glycolipid metabolism (HP:0010969)4.92328904
13Joint hemorrhage (HP:0005261)4.78921184
14Hypolipoproteinemia (HP:0010981)4.71072320
15Hyperammonemia (HP:0001987)4.43855447
16Epidermoid cyst (HP:0200040)4.36873075
17Abnormality of the common coagulation pathway (HP:0010990)4.34653502
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33226670
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31601780
20Fat malabsorption (HP:0002630)4.19247039
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.16727692
22Hyperglycinemia (HP:0002154)4.14328426
23Ketosis (HP:0001946)4.12691557
24Hypoalphalipoproteinemia (HP:0003233)4.02640071
25Abnormality of methionine metabolism (HP:0010901)4.00671891
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98861596
27Recurrent bacterial skin infections (HP:0005406)3.93024134
28Hyperglycinuria (HP:0003108)3.88567019
29Milia (HP:0001056)3.87634223
30Abnormality of complement system (HP:0005339)3.84271393
31Abnormality of glycine metabolism (HP:0010895)3.80633915
32Abnormality of serine family amino acid metabolism (HP:0010894)3.80633915
33Abnormality of macrophages (HP:0004311)3.78083327
34Hypercholesterolemia (HP:0003124)3.77486677
35Increased cerebral lipofuscin (HP:0011813)3.75072706
36Hypoglycemic coma (HP:0001325)3.74651220
37Abnormality of pyrimidine metabolism (HP:0004353)3.74411687
38Recurrent abscess formation (HP:0002722)3.74214734
39Conjugated hyperbilirubinemia (HP:0002908)3.73719573
40Thick nail (HP:0001805)3.71669788
41Abnormality of the intrinsic pathway (HP:0010989)3.66499647
42Vacuolated lymphocytes (HP:0001922)3.65432721
43Orchitis (HP:0100796)3.53007051
44Myositis (HP:0100614)3.52845528
45Dysostosis multiplex (HP:0000943)3.39106146
46Onycholysis (HP:0001806)3.36120639
47Purpura (HP:0000979)3.34921497
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32335174
49Hyperbilirubinemia (HP:0002904)3.29652193
50Plantar hyperkeratosis (HP:0007556)3.28618466
51Abnormality of fatty-acid metabolism (HP:0004359)3.25942638
52Increased neuronal autofluorescent lipopigment (HP:0002074)3.25513730
53Retrobulbar optic neuritis (HP:0100654)3.24242556
54Optic neuritis (HP:0100653)3.24242556
55Myocardial infarction (HP:0001658)3.20277045
56Steatorrhea (HP:0002570)3.08833898
57Loss of speech (HP:0002371)3.07497341
58Fragile nails (HP:0001808)3.01583742
59Systemic lupus erythematosus (HP:0002725)3.00634629
60Eczematoid dermatitis (HP:0000976)2.98732690
61Ketoacidosis (HP:0001993)2.94856311
62* Abnormality of nucleobase metabolism (HP:0010932)2.90999205
63Hepatocellular carcinoma (HP:0001402)2.90261235
64Delayed CNS myelination (HP:0002188)2.89282066
65Abnormality of serum amino acid levels (HP:0003112)2.81149710
66Abnormality of nail color (HP:0100643)2.78859368
67Acanthocytosis (HP:0001927)2.77468749
68Hypochromic microcytic anemia (HP:0004840)2.73513960
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72885574
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72885574
71Abnormality of polysaccharide metabolism (HP:0011012)2.72885574
72Atrophic scars (HP:0001075)2.71925927
73Spontaneous abortion (HP:0005268)2.70998215
74Urinary glycosaminoglycan excretion (HP:0003541)2.69971862
75Mucopolysacchariduria (HP:0008155)2.69971862
76Skin nodule (HP:0200036)2.69362096
77Vascular calcification (HP:0004934)2.69066451
78Metabolic acidosis (HP:0001942)2.67174717
79Glomerulonephritis (HP:0000099)2.64654216
80Keratoconjunctivitis sicca (HP:0001097)2.63826036
81Epistaxis (HP:0000421)2.61202662
82Elevated erythrocyte sedimentation rate (HP:0003565)2.61054166
83Mitral stenosis (HP:0001718)2.56951902
84Recurrent gram-negative bacterial infections (HP:0005420)2.56801784
85Recurrent skin infections (HP:0001581)2.56239368
86Mediastinal lymphadenopathy (HP:0100721)2.55094092
87Obstructive lung disease (HP:0006536)2.51311686
88Chronic obstructive pulmonary disease (HP:0006510)2.51311686
89Increased serum ferritin (HP:0003281)2.49985587
90Alopecia of scalp (HP:0002293)2.49800111
91* Abnormality of purine metabolism (HP:0004352)2.47306953
92Gingivitis (HP:0000230)2.46909811
93Pustule (HP:0200039)2.46606655
94Abnormal blistering of the skin (HP:0008066)2.44706855
95Neurofibrillary tangles (HP:0002185)2.43598139
96Spastic diplegia (HP:0001264)2.41907164
97Gingival bleeding (HP:0000225)2.41558598
98Dicarboxylic aciduria (HP:0003215)2.41518180
99Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41518180
100Cardiovascular calcification (HP:0011915)2.39299347
101Malnutrition (HP:0004395)2.38687154
102Hypoglycemic seizures (HP:0002173)2.38007715
103Abnormal gallbladder morphology (HP:0012437)2.37447381
104Amyloidosis (HP:0011034)2.36475956
105Keratoconjunctivitis (HP:0001096)2.35527753
106Lethargy (HP:0001254)2.35300836
107Gangrene (HP:0100758)2.34099223
108Disinhibition (HP:0000734)2.33180568
109Esophageal varix (HP:0002040)2.32537804
110Cholelithiasis (HP:0001081)2.32470457
111Gout (HP:0001997)2.32348539
112Menorrhagia (HP:0000132)2.31659070
113Irritability (HP:0000737)2.28669436
114Prolonged bleeding time (HP:0003010)2.25631643
115Palmoplantar hyperkeratosis (HP:0000972)2.23382415
116Stomatitis (HP:0010280)2.22892648
117Sensorimotor neuropathy (HP:0007141)2.22609972
118Cholecystitis (HP:0001082)2.22192763
119Abnormal gallbladder physiology (HP:0012438)2.22192763
120Neonatal onset (HP:0003623)2.20288474
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20116478
122Hydroxyprolinuria (HP:0003080)2.18398825
123Abnormality of proline metabolism (HP:0010907)2.18398825
124Poikilocytosis (HP:0004447)2.17088628
125Cheilitis (HP:0100825)2.16171754
126Pulmonary infiltrates (HP:0002113)2.15605631
127Ridged nail (HP:0001807)2.15254182
128Pancreatitis (HP:0001733)2.14881725
129Meningitis (HP:0001287)2.14466671
130Nail dystrophy (HP:0008404)2.13310918
131Thrombophlebitis (HP:0004418)2.12201830
132Recurrent fungal infections (HP:0002841)2.11482191
133Late onset (HP:0003584)2.08083640
134Hemorrhage of the eye (HP:0011885)2.08060875
135Abnormality of iron homeostasis (HP:0011031)2.05262245
136Xerostomia (HP:0000217)2.03795345
137Cerebral edema (HP:0002181)2.03282203
138Abnormality of transition element cation homeostasis (HP:0011030)2.02672104
139Urticaria (HP:0001025)2.02077481
140Palmar hyperkeratosis (HP:0010765)2.01858328
141Autoimmune thrombocytopenia (HP:0001973)2.01023019
142Arterial thrombosis (HP:0004420)2.00974316
143Generalized aminoaciduria (HP:0002909)1.99479880
144Nephritis (HP:0000123)1.99245179
145Vasculitis (HP:0002633)1.97691997
146Polygenic inheritance (HP:0010982)1.96827412
147Hemoptysis (HP:0002105)1.96663370
148Opisthotonus (HP:0002179)1.96450088
149Brushfield spots (HP:0001088)1.95149215
150Periodontitis (HP:0000704)1.95042300
151Abnormality of the gallbladder (HP:0005264)1.93273840
152Vomiting (HP:0002013)1.92860199
153Rickets (HP:0002748)1.89354715
154Abnormal enzyme/coenzyme activity (HP:0012379)1.89031047
155Enlarged kidneys (HP:0000105)1.88495274
156Gastrointestinal infarctions (HP:0005244)1.87882163
157Increased mean platelet volume (HP:0011877)1.87373707
158Hyperinsulinemic hypoglycemia (HP:0000825)1.85572238
159Pulmonary embolism (HP:0002204)1.84768555
160Peritonitis (HP:0002586)1.84051736
161Abnormal cartilage morphology (HP:0002763)1.82454297
162Renal cortical cysts (HP:0000803)1.81840931
163Reticulocytosis (HP:0001923)1.81097334
164Elevated hepatic transaminases (HP:0002910)1.80741076
165Skin ulcer (HP:0200042)1.80501679
166Joint swelling (HP:0001386)1.80349047
167Metaphyseal irregularity (HP:0003025)1.80195927
168Axonal loss (HP:0003447)1.78258024
169Alkalosis (HP:0001948)1.77633220
170Hypophosphatemic rickets (HP:0004912)1.75840179
171Thrombocytosis (HP:0001894)1.74394272

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.76438152
2SIK14.59700681
3ERN14.43056410
4FGFR44.21756491
5TAOK33.43903531
6PKN23.06990716
7RIPK42.47530549
8TRIB32.37466924
9INSRR2.25704154
10TYK22.17123245
11ARAF2.04886826
12ERBB42.02965955
13FLT31.99237498
14MST1R1.86730761
15PIK3CG1.85260206
16PTK61.78810048
17MAPK111.75068531
18PRPF4B1.74093699
19PIM21.72621534
20FRK1.70100312
21FGR1.63206493
22GRK71.63174208
23GRK61.60917257
24MATK1.58047953
25MAP2K41.57479289
26MAP3K21.56744060
27MAP3K101.55698853
28TBK11.53133748
29IRAK41.50216136
30TAOK11.46069289
31MAP2K31.39979202
32JAK11.38261322
33FES1.38031562
34MAP4K11.37142216
35LATS11.34714770
36NEK91.31487556
37JAK21.30868891
38NME21.30391124
39CAMK1D1.27293284
40MAP3K141.25932716
41MAP3K71.21655957
42EPHB11.19408107
43PRKAA21.15911865
44KDR1.14290202
45TGFBR21.14195191
46MAP3K31.13331864
47BMPR21.12162511
48DDR21.07875999
49CSK1.06219548
50CSF1R1.05750165
51MOS1.02888161
52KSR21.02412883
53CDC42BPA1.01038631
54ABL21.00941719
55DAPK21.00871701
56RIPK11.00391112
57FGFR20.97544327
58CDK60.95410453
59MAPK40.93627685
60IKBKE0.91676087
61LCK0.87412782
62CDK120.84047193
63ADRBK20.83710828
64FGFR30.82804723
65IRAK30.82272706
66IRAK10.81918224
67MAP3K110.79725018
68DYRK1B0.76105955
69ZAP700.76063325
70MAPK120.75743139
71EPHA30.74957766
72KIT0.74379881
73PDK20.73776866
74TGFBR10.72173839
75ITK0.71841692
76ERBB20.71390329
77PDGFRA0.69457059
78CAMK1G0.68345609
79MAPK150.68104703
80PRKCZ0.67062458
81ICK0.66068040
82STK38L0.65887227
83ACVR1B0.65314627
84BLK0.64334245
85GSK3A0.62935897
86CDK40.61416551
87MARK30.60833811
88PTK20.60621791
89SGK30.60500345
90PRKACG0.59436352
91BTK0.56882191
92MAP3K130.56619620
93PRKAA10.56305672
94PRKCQ0.55513448
95STK100.55147803
96MAP2K60.55147639
97JAK30.54560991
98TEC0.54398379
99RET0.52622328
100STK240.51164909
101EEF2K0.50978936
102TRPM70.50610348
103MET0.49921387
104MAPK70.48650334
105PDPK10.48256478
106MARK20.47144753
107TNK20.46196392
108IGF1R0.45508844
109RPS6KL10.45309506
110RPS6KC10.45309506
111STK30.44122237
112FER0.44087455
113PDK10.43984107
114RPS6KA20.42425001
115PRKD20.42402243
116MAP3K50.42129628
117IRAK20.41888474
118PDGFRB0.41512989
119CHUK0.41403331
120TAOK20.41290817
121IKBKB0.41221562
122MTOR0.40016871
123LRRK20.39519349
124PAK40.38211602
125SMG10.38131734
126EGFR0.38076842
127BMX0.37600956
128LYN0.35000670
129SYK0.31192124
130TIE10.31077414
131ABL10.30611420
132SGK20.30158728
133TXK0.29432870
134PIM10.29361699
135HCK0.28924667
136MAP3K60.28516592
137CAMK2G0.26842516
138PIK3CA0.25474467
139NUAK10.25417161
140MAP3K10.24751286
141GRK10.24107243

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.46073437
2Other glycan degradation_Homo sapiens_hsa005113.63699394
3Nitrogen metabolism_Homo sapiens_hsa009103.48473988
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47685788
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20970987
6Arginine biosynthesis_Homo sapiens_hsa002203.00230031
7Complement and coagulation cascades_Homo sapiens_hsa046102.74319312
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70800394
9Tryptophan metabolism_Homo sapiens_hsa003802.68827551
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56231363
11Fatty acid degradation_Homo sapiens_hsa000712.48507489
12Leishmaniasis_Homo sapiens_hsa051402.44439916
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41584065
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37760033
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32567501
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16986415
17Caffeine metabolism_Homo sapiens_hsa002322.14823647
18Asthma_Homo sapiens_hsa053102.06927235
19Butanoate metabolism_Homo sapiens_hsa006502.05283295
20Peroxisome_Homo sapiens_hsa041462.05098927
21Osteoclast differentiation_Homo sapiens_hsa043801.97407643
22Chemical carcinogenesis_Homo sapiens_hsa052041.96799316
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94617928
24Staphylococcus aureus infection_Homo sapiens_hsa051501.93790707
25Histidine metabolism_Homo sapiens_hsa003401.93699449
26Allograft rejection_Homo sapiens_hsa053301.91985874
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.90599561
28PPAR signaling pathway_Homo sapiens_hsa033201.89691701
29Propanoate metabolism_Homo sapiens_hsa006401.87147348
30Tuberculosis_Homo sapiens_hsa051521.85748425
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.84835865
32Graft-versus-host disease_Homo sapiens_hsa053321.83546872
33Fatty acid metabolism_Homo sapiens_hsa012121.79481023
34Retinol metabolism_Homo sapiens_hsa008301.71862319
35beta-Alanine metabolism_Homo sapiens_hsa004101.68505387
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65894312
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64651699
38Autoimmune thyroid disease_Homo sapiens_hsa053201.59816709
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58581537
40Malaria_Homo sapiens_hsa051441.57644593
41Selenocompound metabolism_Homo sapiens_hsa004501.57548268
42Toxoplasmosis_Homo sapiens_hsa051451.56411683
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54567357
44Bile secretion_Homo sapiens_hsa049761.54083414
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.49441304
46Rheumatoid arthritis_Homo sapiens_hsa053231.47939071
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47873012
48Hematopoietic cell lineage_Homo sapiens_hsa046401.46277722
49Phenylalanine metabolism_Homo sapiens_hsa003601.44598456
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44037844
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43224954
52Legionellosis_Homo sapiens_hsa051341.38893827
53Starch and sucrose metabolism_Homo sapiens_hsa005001.38849696
54Pyruvate metabolism_Homo sapiens_hsa006201.32652879
55Tyrosine metabolism_Homo sapiens_hsa003501.32050176
56Fat digestion and absorption_Homo sapiens_hsa049751.31723745
57Phagosome_Homo sapiens_hsa041451.29571575
58ABC transporters_Homo sapiens_hsa020101.29564151
59Antigen processing and presentation_Homo sapiens_hsa046121.27226234
60Sulfur metabolism_Homo sapiens_hsa009201.27159436
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26931272
62Folate biosynthesis_Homo sapiens_hsa007901.26404971
63Fatty acid elongation_Homo sapiens_hsa000621.21595875
64Type I diabetes mellitus_Homo sapiens_hsa049401.18485822
65NF-kappa B signaling pathway_Homo sapiens_hsa040641.18480547
66Steroid biosynthesis_Homo sapiens_hsa001001.17977531
67Influenza A_Homo sapiens_hsa051641.17008514
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.15994867
69Sphingolipid metabolism_Homo sapiens_hsa006001.14079434
70Biosynthesis of amino acids_Homo sapiens_hsa012301.12675431
71Carbon metabolism_Homo sapiens_hsa012001.08958874
72TNF signaling pathway_Homo sapiens_hsa046681.06329177
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00698278
74Cyanoamino acid metabolism_Homo sapiens_hsa004601.00102650
75Maturity onset diabetes of the young_Homo sapiens_hsa049501.00018455
76Vitamin digestion and absorption_Homo sapiens_hsa049770.98763353
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97142675
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97100353
79B cell receptor signaling pathway_Homo sapiens_hsa046620.95822516
80Arginine and proline metabolism_Homo sapiens_hsa003300.92630059
81Salmonella infection_Homo sapiens_hsa051320.91972780
82Sulfur relay system_Homo sapiens_hsa041220.89865462
83Lysine degradation_Homo sapiens_hsa003100.89014651
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88784135
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84986021
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82831425
87Vitamin B6 metabolism_Homo sapiens_hsa007500.81576534
88Viral myocarditis_Homo sapiens_hsa054160.81476776
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80891641
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80281318
91Acute myeloid leukemia_Homo sapiens_hsa052210.79610363
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78569261
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74892068
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.72258642
95One carbon pool by folate_Homo sapiens_hsa006700.71888269
96Glycerolipid metabolism_Homo sapiens_hsa005610.71131575
97Measles_Homo sapiens_hsa051620.68898550
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68098682
99Platelet activation_Homo sapiens_hsa046110.66720125
100Glutathione metabolism_Homo sapiens_hsa004800.66584750
101Chemokine signaling pathway_Homo sapiens_hsa040620.66219429
102Herpes simplex infection_Homo sapiens_hsa051680.65291471
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65227220
104Arachidonic acid metabolism_Homo sapiens_hsa005900.64874725
105Fatty acid biosynthesis_Homo sapiens_hsa000610.62680028
106Pentose phosphate pathway_Homo sapiens_hsa000300.61295067
107Apoptosis_Homo sapiens_hsa042100.54473175
108Shigellosis_Homo sapiens_hsa051310.51657429
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51090565
110Bladder cancer_Homo sapiens_hsa052190.50806076
111ECM-receptor interaction_Homo sapiens_hsa045120.48493758
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45641422
113VEGF signaling pathway_Homo sapiens_hsa043700.42037368
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.41976427
115Galactose metabolism_Homo sapiens_hsa000520.41192210
116Non-small cell lung cancer_Homo sapiens_hsa052230.41094544
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40654531
118Metabolic pathways_Homo sapiens_hsa011000.40438879
119Pancreatic cancer_Homo sapiens_hsa052120.39846750
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.39281786
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38634645
122Hepatitis B_Homo sapiens_hsa051610.38097960
123Insulin resistance_Homo sapiens_hsa049310.29967818
124Prion diseases_Homo sapiens_hsa050200.26593796
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.25877383
126Fructose and mannose metabolism_Homo sapiens_hsa000510.24493226
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19892785
128Linoleic acid metabolism_Homo sapiens_hsa005910.14541600
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.11246190
130Glucagon signaling pathway_Homo sapiens_hsa049220.06532093
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.04271485
132AMPK signaling pathway_Homo sapiens_hsa041520.04105428
133Renin-angiotensin system_Homo sapiens_hsa046140.02580368
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02408258
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2049238
136Mineral absorption_Homo sapiens_hsa04978-0.2011374
137Amoebiasis_Homo sapiens_hsa05146-0.1935332
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1764845
139Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1732643
140Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1616055
141Lysosome_Homo sapiens_hsa04142-0.1511877
142RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1431292
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1394535
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1343440
145African trypanosomiasis_Homo sapiens_hsa05143-0.1310859
146Pertussis_Homo sapiens_hsa05133-0.1280877
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1265350
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1139888
149Insulin signaling pathway_Homo sapiens_hsa04910-0.0917931
150Hepatitis C_Homo sapiens_hsa05160-0.0878851
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0743359
152Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0658120
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0414674

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