SLC30A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.50167401
2L-phenylalanine catabolic process (GO:0006559)5.50167401
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.20288872
4L-phenylalanine metabolic process (GO:0006558)5.20288872
5embryonic process involved in female pregnancy (GO:0060136)5.15142417
6aromatic amino acid family catabolic process (GO:0009074)4.93853407
7cysteine metabolic process (GO:0006534)4.81245302
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.70846853
9kynurenine metabolic process (GO:0070189)4.51474535
10indole-containing compound catabolic process (GO:0042436)4.42209292
11indolalkylamine catabolic process (GO:0046218)4.42209292
12tryptophan catabolic process (GO:0006569)4.42209292
13glyoxylate metabolic process (GO:0046487)4.36558503
14tryptophan metabolic process (GO:0006568)4.25267733
15bile acid biosynthetic process (GO:0006699)4.21277320
16complement activation, alternative pathway (GO:0006957)4.20255245
17urea cycle (GO:0000050)4.19981688
18urea metabolic process (GO:0019627)4.19981688
19alpha-linolenic acid metabolic process (GO:0036109)4.17827520
20negative regulation of fibrinolysis (GO:0051918)4.15699462
21hemidesmosome assembly (GO:0031581)4.12692348
22protein carboxylation (GO:0018214)4.12132856
23peptidyl-glutamic acid carboxylation (GO:0017187)4.12132856
24high-density lipoprotein particle remodeling (GO:0034375)4.08002239
25lysine catabolic process (GO:0006554)4.07836571
26lysine metabolic process (GO:0006553)4.07836571
27regulation of protein activation cascade (GO:2000257)4.07562736
28regulation of fibrinolysis (GO:0051917)4.06878745
29sulfur amino acid catabolic process (GO:0000098)4.05347282
30serine family amino acid catabolic process (GO:0009071)3.97999168
31iron ion import (GO:0097286)3.87443194
32regulation of complement activation (GO:0030449)3.86175377
33homocysteine metabolic process (GO:0050667)3.85366197
34nitrogen cycle metabolic process (GO:0071941)3.82206401
35glutamate metabolic process (GO:0006536)3.81196406
36bile acid metabolic process (GO:0008206)3.77614723
37plasma lipoprotein particle clearance (GO:0034381)3.76117210
38phospholipid efflux (GO:0033700)3.75304868
39reverse cholesterol transport (GO:0043691)3.74658256
40bile acid and bile salt transport (GO:0015721)3.74359140
41negative regulation of sterol transport (GO:0032372)3.68265145
42negative regulation of cholesterol transport (GO:0032375)3.68265145
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.63354523
44cell adhesion mediated by integrin (GO:0033627)3.60290642
45dicarboxylic acid biosynthetic process (GO:0043650)3.59053260
46drug catabolic process (GO:0042737)3.58776289
47regulation of cholesterol homeostasis (GO:2000188)3.58416199
48triglyceride homeostasis (GO:0070328)3.58176403
49acylglycerol homeostasis (GO:0055090)3.58176403
50tyrosine metabolic process (GO:0006570)3.57416308
51aromatic amino acid family metabolic process (GO:0009072)3.55222947
52regulation of triglyceride catabolic process (GO:0010896)3.53476605
53cellular ketone body metabolic process (GO:0046950)3.52787179
54glycosphingolipid catabolic process (GO:0046479)3.52115382
55drug transmembrane transport (GO:0006855)3.47839307
56cholesterol efflux (GO:0033344)3.47481991
57protein-lipid complex remodeling (GO:0034368)3.45254115
58macromolecular complex remodeling (GO:0034367)3.45254115
59plasma lipoprotein particle remodeling (GO:0034369)3.45254115
60desmosome organization (GO:0002934)3.44980812
61alpha-amino acid catabolic process (GO:1901606)3.41390884
62amino-acid betaine metabolic process (GO:0006577)3.40891539
63regulation of bile acid biosynthetic process (GO:0070857)3.38954276
64urate metabolic process (GO:0046415)3.32146045
65plasma lipoprotein particle assembly (GO:0034377)3.31228646
66fibrinolysis (GO:0042730)3.30980130
67phospholipid homeostasis (GO:0055091)3.30408175
68very-low-density lipoprotein particle assembly (GO:0034379)3.29413044
69cellular modified amino acid catabolic process (GO:0042219)3.28910971
70cellular glucuronidation (GO:0052695)3.27756508
71regulation of cholesterol esterification (GO:0010872)3.26440371
72heme transport (GO:0015886)3.26181478
73glycolipid catabolic process (GO:0019377)3.22783879
74oligosaccharide catabolic process (GO:0009313)3.21323907
75response to laminar fluid shear stress (GO:0034616)3.20313008
76sterol homeostasis (GO:0055092)3.19386032
77cholesterol homeostasis (GO:0042632)3.18941540
78exogenous drug catabolic process (GO:0042738)3.17414714
79protein-lipid complex assembly (GO:0065005)3.17087298
80cellular amino acid catabolic process (GO:0009063)3.16216021
81aspartate family amino acid catabolic process (GO:0009068)3.12455499
82indolalkylamine metabolic process (GO:0006586)3.09303828
83arginine metabolic process (GO:0006525)3.09062963
84benzene-containing compound metabolic process (GO:0042537)3.08788594
85serine family amino acid metabolic process (GO:0009069)3.08356238
86short-chain fatty acid metabolic process (GO:0046459)3.07528007
87acetyl-CoA metabolic process (GO:0006084)3.02650531
88ketone body metabolic process (GO:1902224)3.02335846
89ethanol oxidation (GO:0006069)3.01149322
90positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97905610
91uronic acid metabolic process (GO:0006063)2.95928815
92glucuronate metabolic process (GO:0019585)2.95928815
93positive regulation of lipid catabolic process (GO:0050996)2.94967478
94lipoprotein metabolic process (GO:0042157)2.91366138
95cellular biogenic amine catabolic process (GO:0042402)2.90639218
96amine catabolic process (GO:0009310)2.90639218
97wound healing, spreading of epidermal cells (GO:0035313)2.89305991
98nuclear pore complex assembly (GO:0051292)2.88981761
99low-density lipoprotein particle clearance (GO:0034383)2.88676832
100lipid homeostasis (GO:0055088)2.88055992
101response to nitrosative stress (GO:0051409)2.87473195
102coenzyme catabolic process (GO:0009109)2.87446343
103flavonoid metabolic process (GO:0009812)2.87000773
104intestinal cholesterol absorption (GO:0030299)2.86807114
105apoptotic cell clearance (GO:0043277)2.83649277
106response to mercury ion (GO:0046689)2.82015594
107plasma lipoprotein particle organization (GO:0071827)2.80978922
108negative regulation of protein localization to plasma membrane (GO:1903077)2.80464069
109glycine metabolic process (GO:0006544)2.79919144
110cellular response to thyroid hormone stimulus (GO:0097067)2.78410504
111negative regulation of lipase activity (GO:0060192)2.77798149
112cellular protein complex localization (GO:0034629)2.77651921
113protein localization to endosome (GO:0036010)2.76606763
114cell-substrate junction assembly (GO:0007044)2.76074270
115protein-lipid complex subunit organization (GO:0071825)2.76009734
116fatty acid oxidation (GO:0019395)2.75599987
117negative regulation of fatty acid transport (GO:2000192)2.75031158
118midgut development (GO:0007494)2.74635074
119regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73675943
120skin morphogenesis (GO:0043589)2.63992636
121positive regulation of extracellular matrix organization (GO:1903055)2.63477350
122positive regulation of endothelial cell apoptotic process (GO:2000353)2.62987976
123nuclear pore organization (GO:0006999)2.61671602
124endodermal cell differentiation (GO:0035987)2.61060650
125gap junction assembly (GO:0016264)2.58793535
126ceramide catabolic process (GO:0046514)2.57643825
127regulation of early endosome to late endosome transport (GO:2000641)2.57242318
128COPII vesicle coating (GO:0048208)2.56198472
129positive regulation of p38MAPK cascade (GO:1900745)2.53438962
130cellular response to arsenic-containing substance (GO:0071243)2.51694821
131wound healing, spreading of cells (GO:0044319)2.51445647
132positive regulation of cholesterol efflux (GO:0010875)2.49672165
133cytoskeletal anchoring at plasma membrane (GO:0007016)2.47816942
134positive regulation of sterol transport (GO:0032373)2.46658178
135positive regulation of cholesterol transport (GO:0032376)2.46658178
136regulation of vitamin metabolic process (GO:0030656)2.45876889
137epithelial cell differentiation involved in prostate gland development (GO:0060742)2.45124078
138intestinal absorption (GO:0050892)2.44793925
139epoxygenase P450 pathway (GO:0019373)2.44091046
140angiotensin maturation (GO:0002003)2.42793707
141response to thyroid hormone (GO:0097066)2.41912032
142pinocytosis (GO:0006907)2.41355777
143detection of molecule of bacterial origin (GO:0032490)2.40170373
144mammary gland epithelial cell proliferation (GO:0033598)2.38626539
145bundle of His cell to Purkinje myocyte communication (GO:0086069)2.38619610
146omega-hydroxylase P450 pathway (GO:0097267)2.37639950
147hyaluronan catabolic process (GO:0030214)2.36713710
148decidualization (GO:0046697)2.34895817
149epithelial cell-cell adhesion (GO:0090136)2.34411924
150regulation of macrophage chemotaxis (GO:0010758)2.33866721
151negative regulation of fatty acid biosynthetic process (GO:0045717)2.32961358
152negative regulation of lipid transport (GO:0032369)2.32872436
153fat-soluble vitamin biosynthetic process (GO:0042362)2.32359653
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.31317698
155surfactant homeostasis (GO:0043129)2.31188247
156Rap protein signal transduction (GO:0032486)2.30513713
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.30438031
158positive regulation of osteoblast proliferation (GO:0033690)2.28846420
159negative regulation of protein activation cascade (GO:2000258)2.28413394
160basement membrane organization (GO:0071711)2.27788572
161cellular response to ethanol (GO:0071361)2.27681606
162pore complex assembly (GO:0046931)2.26571661
163positive regulation of blood coagulation (GO:0030194)2.26529863
164positive regulation of hemostasis (GO:1900048)2.26529863
165regulation of vitamin D biosynthetic process (GO:0060556)2.26447423
166hepatocyte differentiation (GO:0070365)2.25491384
167negative regulation of complement activation (GO:0045916)2.24370500
168regulation of transforming growth factor beta1 production (GO:0032908)2.23253373
169negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.23145419
170positive regulation of coagulation (GO:0050820)2.22103543
171response to arsenic-containing substance (GO:0046685)2.20478691
172osteoclast differentiation (GO:0030316)2.20242232
173negative regulation of anoikis (GO:2000811)2.20025948
174regulation of apoptotic cell clearance (GO:2000425)2.19948914
175regulation of cholesterol storage (GO:0010885)2.19906375
176stress fiber assembly (GO:0043149)2.19442945
177branching involved in mammary gland duct morphogenesis (GO:0060444)2.18395677
178positive regulation of Cdc42 GTPase activity (GO:0043089)2.18012779
179sphingosine metabolic process (GO:0006670)2.16412375
180ER overload response (GO:0006983)2.16269452

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.91678189
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.09127550
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38324584
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.29940994
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.41047817
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.25342130
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.89036019
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71515909
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.71175468
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.34941875
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28644644
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24209129
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.18712482
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.18712482
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07555547
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02341049
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01851402
18CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96843003
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81420940
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.78995549
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.78941664
22* AR_21909140_ChIP-Seq_LNCAP_Human1.75810993
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75763463
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.69974715
25CLOCK_20551151_ChIP-Seq_293T_Human1.66203098
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.63141598
27GATA1_22025678_ChIP-Seq_K562_Human1.61379506
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58845366
29* IRF8_27001747_Chip-Seq_BMDM_Mouse1.57508113
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.57426260
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.57391228
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.54412855
33* UBF1/2_26484160_Chip-Seq_HMECs_Human1.48642051
34GATA1_19941826_ChIP-Seq_K562_Human1.48144558
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45719491
36EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.45185643
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.43441389
38* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43012248
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40985432
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40010075
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38615264
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37069691
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36856595
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36644898
45ATF3_27146783_Chip-Seq_COLON_Human1.35817052
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.34200952
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.33506880
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29713799
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29644612
50* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28564751
51TFEB_21752829_ChIP-Seq_HELA_Human1.24222266
52* ELK3_25401928_ChIP-Seq_HUVEC_Human1.23826707
53ZNF263_19887448_ChIP-Seq_K562_Human1.22989480
54* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22320179
55* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21896499
56* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21896499
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21303235
58PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21068855
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.16741583
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16620373
61AR_21572438_ChIP-Seq_LNCaP_Human1.15565225
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14644810
63PU_27001747_Chip-Seq_BMDM_Mouse1.11803981
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.09514409
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.07263132
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06877784
67BRD4_25478319_ChIP-Seq_HGPS_Human1.06255592
68* TP53_18474530_ChIP-ChIP_U2OS_Human1.05446058
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.04859559
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04514026
71CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03950911
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03490946
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.01968175
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01341618
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01259239
76* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00321850
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00237903
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00038835
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99638743
80GATA4_25053715_ChIP-Seq_YYC3_Human0.98923082
81GATA2_19941826_ChIP-Seq_K562_Human0.98448012
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97946372
83NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96636992
84VDR_24787735_ChIP-Seq_THP-1_Human0.95568219
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95318251
86RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95202064
87BCAT_22108803_ChIP-Seq_LS180_Human0.94947628
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94579492
89E2F7_22180533_ChIP-Seq_HELA_Human0.93796329
90* CHD1_26751641_Chip-Seq_LNCaP_Human0.93593357
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92850443
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92186641
93SOX2_20726797_ChIP-Seq_SW620_Human0.92089754
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.90816093
95TP63_23658742_ChIP-Seq_EP156T_Human0.90769286
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87632434
97RXR_22108803_ChIP-Seq_LS180_Human0.87513883
98ESR1_20079471_ChIP-ChIP_T-47D_Human0.87425016
99SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86682051
100STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86107984
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85073479
102* KDM2B_26808549_Chip-Seq_K562_Human0.84255275
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84082362
104* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82814692
105STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81765505
106FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80114013
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.79967290
108EGR1_19032775_ChIP-ChIP_M12_Human0.79961107
109* GATA6_25053715_ChIP-Seq_YYC3_Human0.79737745
110RACK7_27058665_Chip-Seq_MCF-7_Human0.79626898
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79617664
112* AHR_22903824_ChIP-Seq_MCF-7_Human0.79135269
113* ARNT_22903824_ChIP-Seq_MCF-7_Human0.78322896
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78288280
115* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78054250
116GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77202347
117CJUN_26792858_Chip-Seq_BT549_Human0.77191529
118PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77006040
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.75914325
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75792443
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.75417082
122* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75191661
123TP53_16413492_ChIP-PET_HCT116_Human0.73557020
124* SMAD3_21741376_ChIP-Seq_HESCs_Human0.72706588
125CDX2_22108803_ChIP-Seq_LS180_Human0.72612754
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.71607633
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.71607633
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71570179
129NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70985778
130AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70676311
131MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70497121
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.69362731
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.68583266
134* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68567913
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68305759
136* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67869304
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.67494692
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.67256001
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67253797
140IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.66453026
141* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.65810054
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65471629
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65190554
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.64869286
145FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64804493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.38081854
2MP0002139_abnormal_hepatobiliary_system6.17343255
3MP0005085_abnormal_gallbladder_physiolo4.89606311
4MP0005365_abnormal_bile_salt4.48591651
5MP0008875_abnormal_xenobiotic_pharmacok4.27887806
6MP0003252_abnormal_bile_duct3.05040774
7MP0010352_gastrointestinal_tract_polyps3.04881738
8MP0010329_abnormal_lipoprotein_level2.87952974
9MP0010234_abnormal_vibrissa_follicle2.85465113
10MP0003191_abnormal_cellular_cholesterol2.60030314
11MP0005167_abnormal_blood-brain_barrier2.59224756
12MP0009840_abnormal_foam_cell2.47404861
13MP0005332_abnormal_amino_acid2.32749452
14MP0002796_impaired_skin_barrier2.29525112
15MP0005083_abnormal_biliary_tract2.28857841
16MP0008438_abnormal_cutaneous_collagen2.27707781
17MP0001666_abnormal_nutrient_absorption2.24067517
18MP0003705_abnormal_hypodermis_morpholog2.21629849
19MP0004019_abnormal_vitamin_homeostasis2.10504806
20MP0003806_abnormal_nucleotide_metabolis2.06792090
21MP0002877_abnormal_melanocyte_morpholog2.01393306
22MP0010678_abnormal_skin_adnexa1.99109925
23MP0003195_calcinosis1.98700788
24MP0002138_abnormal_hepatobiliary_system1.97980424
25MP0003828_pulmonary_edema1.88313496
26MP0003091_abnormal_cell_migration1.87807195
27MP0002254_reproductive_system_inflammat1.82859458
28MP0000579_abnormal_nail_morphology1.82241541
29MP0002118_abnormal_lipid_homeostasis1.78042205
30MP0000609_abnormal_liver_physiology1.76749577
31MP0005076_abnormal_cell_differentiation1.74187918
32MP0002822_catalepsy1.72525618
33MP0001661_extended_life_span1.72462229
34MP0000383_abnormal_hair_follicle1.65674259
35MP0005409_darkened_coat_color1.64976454
36MP0002098_abnormal_vibrissa_morphology1.61643586
37MP0000537_abnormal_urethra_morphology1.59901977
38MP0002009_preneoplasia1.56261410
39MP0010307_abnormal_tumor_latency1.49651703
40MP0005023_abnormal_wound_healing1.49305460
41MP0000647_abnormal_sebaceous_gland1.48769778
42MP0003690_abnormal_glial_cell1.42938796
43MP0010368_abnormal_lymphatic_system1.42035036
44MP0001849_ear_inflammation1.36541882
45MP0000858_altered_metastatic_potential1.34871826
46MP0005058_abnormal_lysosome_morphology1.32810053
47MP0003868_abnormal_feces_composition1.31668635
48MP0005319_abnormal_enzyme/_coenzyme1.31388722
49MP0008260_abnormal_autophagy1.29881288
50MP0009643_abnormal_urine_homeostasis1.29820723
51MP0009053_abnormal_anal_canal1.28228687
52MP0003300_gastrointestinal_ulcer1.27963169
53MP0005451_abnormal_body_composition1.24533487
54MP0005501_abnormal_skin_physiology1.24413618
55MP0003448_altered_tumor_morphology1.23293788
56MP0000377_abnormal_hair_follicle1.18473191
57MP0005584_abnormal_enzyme/coenzyme_acti1.17856265
58MP0006082_CNS_inflammation1.15835025
59MP0001915_intracranial_hemorrhage1.15333758
60MP0002998_abnormal_bone_remodeling1.15166461
61MP0000427_abnormal_hair_cycle1.13147293
62MP0000604_amyloidosis1.11768517
63MP0005257_abnormal_intraocular_pressure1.11027407
64MP0004185_abnormal_adipocyte_glucose1.10192685
65MP0003453_abnormal_keratinocyte_physiol1.08408738
66MP0004885_abnormal_endolymph1.08338034
67MP0004043_abnormal_pH_regulation1.07349758
68MP0000343_altered_response_to1.06878050
69MP0005164_abnormal_response_to1.06421979
70MP0005670_abnormal_white_adipose1.06312889
71MP0003172_abnormal_lysosome_physiology1.01439418
72MP0004130_abnormal_muscle_cell1.01182640
73MP0003436_decreased_susceptibility_to1.00053807
74MP0002166_altered_tumor_susceptibility0.97361772
75MP0001851_eye_inflammation0.97209984
76MP0001191_abnormal_skin_condition0.97139821
77MP0008057_abnormal_DNA_replication0.97110381
78MP0004272_abnormal_basement_membrane0.92901732
79MP0003656_abnormal_erythrocyte_physiolo0.92021974
80MP0006054_spinal_hemorrhage0.91611041
81MP0004947_skin_inflammation0.89646517
82MP0002419_abnormal_innate_immunity0.89211379
83MP0004264_abnormal_extraembryonic_tissu0.88568334
84MP0005666_abnormal_adipose_tissue0.87548882
85MP0002971_abnormal_brown_adipose0.86968534
86MP0003329_amyloid_beta_deposits0.86922839
87MP0000767_abnormal_smooth_muscle0.85694573
88MP0005275_abnormal_skin_tensile0.85642762
89MP0000598_abnormal_liver_morphology0.84624809
90MP0010155_abnormal_intestine_physiology0.83048574
91MP0004233_abnormal_muscle_weight0.82223665
92MP0005636_abnormal_mineral_homeostasis0.81970620
93MP0003279_aneurysm0.81514481
94MP0003183_abnormal_peptide_metabolism0.81238663
95MP0005248_abnormal_Harderian_gland0.80222129
96MP0001216_abnormal_epidermal_layer0.80190557
97MP0009384_cardiac_valve_regurgitation0.79943038
98MP0001756_abnormal_urination0.79424445
99MP0002086_abnormal_extraembryonic_tissu0.79241064
100MP0003941_abnormal_skin_development0.79165751
101MP0001533_abnormal_skeleton_physiology0.77471808
102MP0002006_tumorigenesis0.75492096
103MP0009764_decreased_sensitivity_to0.75326020
104MP0009785_altered_susceptibility_to0.75274671
105MP0005397_hematopoietic_system_phenotyp0.75120114
106MP0001545_abnormal_hematopoietic_system0.75120114
107MP0003075_altered_response_to0.75110371
108MP0005621_abnormal_cell_physiology0.73947622
109MP0001853_heart_inflammation0.73323377
110MP0005084_abnormal_gallbladder_morpholo0.73304462
111MP0000467_abnormal_esophagus_morphology0.72028796
112MP0005197_abnormal_uvea_morphology0.71203319
113MP0002295_abnormal_pulmonary_circulatio0.70956820
114MP0003950_abnormal_plasma_membrane0.70799067
115MP0009763_increased_sensitivity_to0.70665817
116MP0000627_abnormal_mammary_gland0.70240348
117MP0004808_abnormal_hematopoietic_stem0.69561461
118MP0000920_abnormal_myelination0.69398521
119MP0002148_abnormal_hypersensitivity_rea0.68621355
120MP0002136_abnormal_kidney_physiology0.67358572
121MP0002090_abnormal_vision0.66927973
122MP0009765_abnormal_xenobiotic_induced0.66597468
123MP0010771_integument_phenotype0.66549388
124MP0005647_abnormal_sex_gland0.66170389
125MP0004782_abnormal_surfactant_physiolog0.65526856
126MP0005623_abnormal_meninges_morphology0.64105716
127MP0005535_abnormal_body_temperature0.62544735
128MP0003633_abnormal_nervous_system0.62319307
129MP0003566_abnormal_cell_adhesion0.61542965
130MP0003303_peritoneal_inflammation0.61440555
131MP0001879_abnormal_lymphatic_vessel0.61237779
132MP0004147_increased_porphyrin_level0.60544618
133MP0005166_decreased_susceptibility_to0.60504017
134MP0003011_delayed_dark_adaptation0.60074537
135MP0005334_abnormal_fat_pad0.57989190
136MP0003186_abnormal_redox_activity0.56849012
137MP0002078_abnormal_glucose_homeostasis0.55859252
138MP0002060_abnormal_skin_morphology0.55577945
139MP0003638_abnormal_response/metabolism_0.55221564
140MP0001765_abnormal_ion_homeostasis0.54936177
141MP0005187_abnormal_penis_morphology0.54841591
142MP0009931_abnormal_skin_appearance0.54029049
143MP0009642_abnormal_blood_homeostasis0.53938796
144MP0005408_hypopigmentation0.51433815
145MP0002896_abnormal_bone_mineralization0.51261165
146MP0005375_adipose_tissue_phenotype0.50840671
147MP0008874_decreased_physiological_sensi0.50321224
148MP0005330_cardiomyopathy0.50097104
149MP0005165_increased_susceptibility_to0.49537962
150MP0009697_abnormal_copulation0.49367442

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.89348961
2Intrahepatic cholestasis (HP:0001406)5.63411589
3Xanthomatosis (HP:0000991)5.44496858
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.77439200
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.76119241
6Hyperlipoproteinemia (HP:0010980)4.71198656
7Complement deficiency (HP:0004431)4.52429884
8Hypobetalipoproteinemia (HP:0003563)4.13685661
9Prolonged partial thromboplastin time (HP:0003645)4.11949116
10Abnormality of glutamine family amino acid metabolism (HP:0010902)3.78073322
11Hypoalphalipoproteinemia (HP:0003233)3.71407484
12Hypolipoproteinemia (HP:0010981)3.66006722
13Epidermoid cyst (HP:0200040)3.61581275
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.60266529
15Abnormality of glycolipid metabolism (HP:0010969)3.58169337
16Abnormality of liposaccharide metabolism (HP:0010968)3.58169337
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.58169337
18Abnormality of complement system (HP:0005339)3.31610644
19Hyperammonemia (HP:0001987)3.31063323
20Hyperglycinemia (HP:0002154)3.28021397
21Fat malabsorption (HP:0002630)3.24836205
22Hypercholesterolemia (HP:0003124)3.24325854
23Abnormality of the common coagulation pathway (HP:0010990)3.18982225
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.17489421
25Ketosis (HP:0001946)3.13895724
26Osteolytic defects of the hand bones (HP:0009699)3.12033940
27Osteolytic defects of the phalanges of the hand (HP:0009771)3.12033940
28Joint hemorrhage (HP:0005261)3.10845610
29Hypoglycemic coma (HP:0001325)3.10664357
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.05150067
31Abnormality of serine family amino acid metabolism (HP:0010894)3.02071291
32Abnormality of glycine metabolism (HP:0010895)3.02071291
33Malnutrition (HP:0004395)3.00998706
34Increased cerebral lipofuscin (HP:0011813)2.94171007
35Esophageal varix (HP:0002040)2.92650383
36Polycythemia (HP:0001901)2.91650613
37Hyperglycinuria (HP:0003108)2.91019866
38Myocardial infarction (HP:0001658)2.80733542
39Gout (HP:0001997)2.77121194
40Abnormality of purine metabolism (HP:0004352)2.74495468
41Vertebral compression fractures (HP:0002953)2.71069995
42Acanthocytosis (HP:0001927)2.62078214
43Atrophic scars (HP:0001075)2.57460292
44Delayed CNS myelination (HP:0002188)2.57282324
45Onycholysis (HP:0001806)2.54974465
46Systemic lupus erythematosus (HP:0002725)2.54700312
47Status epilepticus (HP:0002133)2.53755010
48Hepatocellular carcinoma (HP:0001402)2.53644230
49Premature rupture of membranes (HP:0001788)2.53429230
50Sensorimotor neuropathy (HP:0007141)2.49132264
51Abnormality of nail color (HP:0100643)2.48536260
52Abnormality of methionine metabolism (HP:0010901)2.47840317
53Hemorrhage of the eye (HP:0011885)2.43308290
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.40508470
55Right ventricular cardiomyopathy (HP:0011663)2.39750612
56Tetraparesis (HP:0002273)2.38640568
57Confusion (HP:0001289)2.35089618
58Abnormality of nucleobase metabolism (HP:0010932)2.34184118
59Flat acetabular roof (HP:0003180)2.33857010
60Reticulocytosis (HP:0001923)2.33805600
61Abnormality of the intrinsic pathway (HP:0010989)2.33754138
62Cerebral inclusion bodies (HP:0100314)2.32612198
63Skin nodule (HP:0200036)2.32580227
64Spastic diplegia (HP:0001264)2.32405752
65Steatorrhea (HP:0002570)2.32011907
66Conjugated hyperbilirubinemia (HP:0002908)2.31925593
67Arterial tortuosity (HP:0005116)2.31885912
68Neurofibrillary tangles (HP:0002185)2.30188811
69Hyperbilirubinemia (HP:0002904)2.30163721
70Ketoacidosis (HP:0001993)2.28958287
71Vascular calcification (HP:0004934)2.28438232
72Hypochromic microcytic anemia (HP:0004840)2.27907208
73Alopecia of scalp (HP:0002293)2.27734940
74Milia (HP:0001056)2.24930121
75Spontaneous abortion (HP:0005268)2.24316753
76Vacuolated lymphocytes (HP:0001922)2.23879107
77Poikilocytosis (HP:0004447)2.21394298
78Glomerulonephritis (HP:0000099)2.20817434
79Hyperuricemia (HP:0002149)2.20512381
80Increased purine levels (HP:0004368)2.20512381
81Dysostosis multiplex (HP:0000943)2.20276227
82Eczematoid dermatitis (HP:0000976)2.19224140
83Protrusio acetabuli (HP:0003179)2.17967919
84Axonal loss (HP:0003447)2.17631781
85Increased CSF protein (HP:0002922)2.17126465
86Syringomyelia (HP:0003396)2.13739709
87Spinal cord lesions (HP:0100561)2.13739709
88Rickets (HP:0002748)2.13435242
89Bone pain (HP:0002653)2.13180783
90Abnormal cartilage morphology (HP:0002763)2.13148318
91Mucopolysacchariduria (HP:0008155)2.08625058
92Urinary glycosaminoglycan excretion (HP:0003541)2.08625058
93Global brain atrophy (HP:0002283)2.08622039
94Cardiovascular calcification (HP:0011915)2.08087503
95Abnormality of fatty-acid metabolism (HP:0004359)2.07963849
96Back pain (HP:0003418)2.07490696
97Vascular tortuosity (HP:0004948)2.06953279
98Plantar hyperkeratosis (HP:0007556)2.06718093
99Follicular hyperkeratosis (HP:0007502)2.05964532
100Subacute progressive viral hepatitis (HP:0006572)2.02633762
101Cerebral aneurysm (HP:0004944)2.02495997
102Cholelithiasis (HP:0001081)2.02481002
103Abnormality of proline metabolism (HP:0010907)2.01689197
104Hydroxyprolinuria (HP:0003080)2.01689197
105Abnormal gallbladder morphology (HP:0012437)2.00609936
106Ankyloglossia (HP:0010296)1.99506585
107Nephritis (HP:0000123)1.98940483
108Pathologic fracture (HP:0002756)1.98798523
109Hypotrichosis (HP:0001006)1.97897676
110Woolly hair (HP:0002224)1.97599859
111Asymmetry of the thorax (HP:0001555)1.97571510
112Abnormality of the Achilles tendon (HP:0005109)1.97467576
113Abnormality of polysaccharide metabolism (HP:0011012)1.97279530
114Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97279530
115Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97279530
116Thin bony cortex (HP:0002753)1.94912053
117Fragile skin (HP:0001030)1.92949821
118Natal tooth (HP:0000695)1.92944000
119Abnormality of macrophages (HP:0004311)1.91107285
120Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89933432
121Intention tremor (HP:0002080)1.89537514
122Hypoglycemic seizures (HP:0002173)1.88276948
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87851002
124Periodontitis (HP:0000704)1.87512966
125Metabolic acidosis (HP:0001942)1.86517886
126Loss of speech (HP:0002371)1.84910528
127Disinhibition (HP:0000734)1.84346658
128Hypophosphatemic rickets (HP:0004912)1.84338006
129Recurrent gram-negative bacterial infections (HP:0005420)1.83219406
130Hyperinsulinemic hypoglycemia (HP:0000825)1.82269451
131Abnormal gallbladder physiology (HP:0012438)1.81252964
132Cholecystitis (HP:0001082)1.81252964
133Upper motor neuron abnormality (HP:0002127)1.81041291
134Pili torti (HP:0003777)1.80893183
135Irritability (HP:0000737)1.80849947
136Hematochezia (HP:0002573)1.80010220
137Protuberant abdomen (HP:0001538)1.78310334
138Alkalosis (HP:0001948)1.78188341
139Pigmentary retinal degeneration (HP:0001146)1.77040232
140Wormian bones (HP:0002645)1.76400787
141Advanced eruption of teeth (HP:0006288)1.76249567
142Coarse hair (HP:0002208)1.75886950
143Abnormality of oral frenula (HP:0000190)1.75603756
144Conjunctival telangiectasia (HP:0000524)1.75476126
145Neonatal onset (HP:0003623)1.75053402
146Short nail (HP:0001799)1.73193557
147Amyloidosis (HP:0011034)1.72254072
148Thick nail (HP:0001805)1.70501698
149Mitral stenosis (HP:0001718)1.70351143
150Visceral angiomatosis (HP:0100761)1.69962440
151Abnormality of serum amino acid levels (HP:0003112)1.69285832
152Focal segmental glomerulosclerosis (HP:0000097)1.69281389
153Nuclear cataract (HP:0100018)1.68804982
154Curly hair (HP:0002212)1.68304688
155Fragile nails (HP:0001808)1.68000194
156Abnormality of the lumbar spine (HP:0100712)1.67102360
157Abnormality of carpal bone ossification (HP:0006257)1.66392856
158Hyperparathyroidism (HP:0000843)1.65202134
159Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.65028092
160Cervical subluxation (HP:0003308)1.64073076
161Ridged nail (HP:0001807)1.62385616
162Gingivitis (HP:0000230)1.60395790
163Spondylolisthesis (HP:0003302)1.59231366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R3.70593113
2LATS12.89056690
3PRPF4B2.88244928
4KSR22.87396209
5BRD42.82494105
6MAP3K22.61747942
7BRSK22.37989140
8IRAK32.21759149
9EPHA42.17495090
10STK241.95300542
11MET1.92007673
12ACVR1B1.91545880
13TIE11.87973406
14FGFR41.76835878
15PIM21.58598721
16ERBB41.58320295
17TAOK11.58116923
18SCYL21.57652341
19NEK91.53951996
20WNK41.53033240
21FGFR21.51605855
22MAP3K141.51557022
23AKT31.48953942
24ERN11.47006502
25PBK1.44528577
26TAOK31.41547233
27KDR1.41230326
28PTK61.39487597
29WEE11.38075309
30BMPR21.35547983
31TRIB31.34941541
32MAP3K101.34586680
33PAK41.34448826
34INSRR1.32507037
35SIK11.31973837
36RET1.31480127
37MAP2K41.31132570
38EPHB11.30836127
39DDR21.29112293
40BCKDK1.27960052
41PTK21.26830845
42MAP3K11.26287884
43DMPK1.25655674
44TYK21.25594443
45STK391.25134430
46PIK3CA1.24998645
47TTN1.22829015
48EPHA21.21278982
49FER1.19802329
50RIPK11.19420176
51PDPK11.16086310
52LATS21.13182469
53OXSR11.10835408
54CDK61.08774561
55TSSK61.05768577
56TYRO31.04815510
57PTK2B1.04291311
58FRK1.03046074
59PAK61.02427302
60MAP2K11.01606003
61WNK11.00796230
62EIF2AK31.00694681
63PRKAA21.00375855
64TAOK21.00364028
65MAP3K71.00342064
66CDK120.98256836
67YES10.97707280
68PKN20.96413737
69MELK0.94343934
70PRKD30.93984325
71BMX0.92902016
72TRPM70.92618570
73MAP3K90.92207234
74MAP3K30.91574607
75EIF2AK10.90312546
76JAK20.90206297
77PAK30.90203855
78STK30.89605422
79ABL20.89268922
80CAMK1G0.88357053
81SMG10.88142919
82ICK0.87507498
83PIM10.87457184
84SGK30.86331754
85MAP2K20.85940610
86ALK0.85414498
87MAP2K30.83960950
88STK380.82238001
89GSK3A0.81770920
90MAP3K60.79107322
91GRK10.79091779
92IRAK20.78835712
93TBK10.76033160
94MAPK110.75921815
95SGK4940.75572598
96SGK2230.75572598
97DYRK1B0.74406018
98MAP3K40.72866903
99FGR0.70890468
100PDGFRB0.70747002
101PKN10.70085908
102PDK10.69847657
103CAMK1D0.69729783
104MATK0.69687684
105MAP3K50.67228570
106NEK60.66636254
107EPHB20.66125030
108DAPK20.65635171
109EEF2K0.65322141
110NME20.63941391
111CSNK1G10.63721858
112WNK30.63072356
113TGFBR20.62687220
114CSK0.62654853
115NTRK10.62329364
116PDGFRA0.62212154
117MAP3K110.61408996
118PRKD10.61388825
119BLK0.60941548
120STK38L0.60619260
121PRKCZ0.60530344
122PRKCH0.59988671
123PDK20.59769833
124PRKAA10.57871823
125SGK20.57214570
126MAP3K130.56805858
127JAK10.56362084
128CDC42BPA0.55536506
129MTOR0.54677812
130SGK10.54262245
131ERBB20.54253002
132IRAK40.54112667
133CSNK1G20.53433274
134FGFR30.53342136
135KSR10.52316885
136IRAK10.52167689
137PRKCQ0.51562176
138PAK20.51213342
139MOS0.50461120
140MAP3K80.46710683
141BRSK10.45585529
142ARAF0.43488076
143JAK30.43013946
144GRK70.42142607
145PRKG20.41906043
146MST40.40105435
147MAPK70.38184384
148ERBB30.36101248
149RPS6KA20.35543361
150DYRK30.34680251
151TGFBR10.34664173

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.60365237
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.62968604
3Arginine biosynthesis_Homo sapiens_hsa002203.19553402
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.86975784
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82707694
6Complement and coagulation cascades_Homo sapiens_hsa046102.45943996
7Other glycan degradation_Homo sapiens_hsa005112.37337046
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21100939
9Tryptophan metabolism_Homo sapiens_hsa003802.20525615
10Bile secretion_Homo sapiens_hsa049762.15141305
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.08013971
12Fatty acid degradation_Homo sapiens_hsa000712.06588201
13Butanoate metabolism_Homo sapiens_hsa006502.02179738
14PPAR signaling pathway_Homo sapiens_hsa033201.97239126
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91997964
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.87788653
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85415647
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81811586
19Staphylococcus aureus infection_Homo sapiens_hsa051501.72032790
20Caffeine metabolism_Homo sapiens_hsa002321.67199670
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60263050
22Peroxisome_Homo sapiens_hsa041461.56751093
23Histidine metabolism_Homo sapiens_hsa003401.53897247
24Fatty acid metabolism_Homo sapiens_hsa012121.53765604
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53097349
26Propanoate metabolism_Homo sapiens_hsa006401.52312967
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49689127
28Sulfur metabolism_Homo sapiens_hsa009201.48838633
29Chemical carcinogenesis_Homo sapiens_hsa052041.42142407
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42042895
31Fat digestion and absorption_Homo sapiens_hsa049751.41399576
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37134452
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.36636927
34Amoebiasis_Homo sapiens_hsa051461.34685990
35ABC transporters_Homo sapiens_hsa020101.32506360
36Small cell lung cancer_Homo sapiens_hsa052221.32154419
37Sphingolipid metabolism_Homo sapiens_hsa006001.29724131
38beta-Alanine metabolism_Homo sapiens_hsa004101.28615616
39Chronic myeloid leukemia_Homo sapiens_hsa052201.25498279
40Malaria_Homo sapiens_hsa051441.24285006
41Steroid biosynthesis_Homo sapiens_hsa001001.23300186
42TNF signaling pathway_Homo sapiens_hsa046681.20266095
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19950719
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18524647
45Retinol metabolism_Homo sapiens_hsa008301.14376110
46p53 signaling pathway_Homo sapiens_hsa041151.14267755
47Galactose metabolism_Homo sapiens_hsa000521.13263625
48Osteoclast differentiation_Homo sapiens_hsa043801.11210628
49Starch and sucrose metabolism_Homo sapiens_hsa005001.09857298
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08021393
51Vitamin digestion and absorption_Homo sapiens_hsa049771.08010342
52Toxoplasmosis_Homo sapiens_hsa051451.05741913
53Selenocompound metabolism_Homo sapiens_hsa004501.05690301
54Phenylalanine metabolism_Homo sapiens_hsa003601.04682785
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02771706
56Renin-angiotensin system_Homo sapiens_hsa046141.02399738
57Glycerolipid metabolism_Homo sapiens_hsa005610.98511265
58Pertussis_Homo sapiens_hsa051330.98191593
59Apoptosis_Homo sapiens_hsa042100.97951756
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.96512261
61MicroRNAs in cancer_Homo sapiens_hsa052060.96004551
62Pancreatic cancer_Homo sapiens_hsa052120.95803690
63Influenza A_Homo sapiens_hsa051640.93925816
64Focal adhesion_Homo sapiens_hsa045100.93925270
65Thyroid cancer_Homo sapiens_hsa052160.93335252
66Vitamin B6 metabolism_Homo sapiens_hsa007500.91656212
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91590316
68Prostate cancer_Homo sapiens_hsa052150.91466347
69Tyrosine metabolism_Homo sapiens_hsa003500.89094372
70Fatty acid elongation_Homo sapiens_hsa000620.88776094
71Pyruvate metabolism_Homo sapiens_hsa006200.88350381
72TGF-beta signaling pathway_Homo sapiens_hsa043500.88174299
73Dorso-ventral axis formation_Homo sapiens_hsa043200.87555682
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87350237
75Legionellosis_Homo sapiens_hsa051340.87175851
76Hepatitis B_Homo sapiens_hsa051610.86037827
77FoxO signaling pathway_Homo sapiens_hsa040680.84756015
78Arginine and proline metabolism_Homo sapiens_hsa003300.84157582
79Leishmaniasis_Homo sapiens_hsa051400.80587446
80Tuberculosis_Homo sapiens_hsa051520.80039219
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78629518
82HIF-1 signaling pathway_Homo sapiens_hsa040660.77980335
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.77882800
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77547376
85Lysine degradation_Homo sapiens_hsa003100.77520345
86African trypanosomiasis_Homo sapiens_hsa051430.75786137
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74810625
88* Mineral absorption_Homo sapiens_hsa049780.74191638
89Acute myeloid leukemia_Homo sapiens_hsa052210.73673775
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73609123
91Carbon metabolism_Homo sapiens_hsa012000.73449389
92Biosynthesis of amino acids_Homo sapiens_hsa012300.72892896
93Measles_Homo sapiens_hsa051620.69706181
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.68099488
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.67642797
96Fatty acid biosynthesis_Homo sapiens_hsa000610.65881838
97Folate biosynthesis_Homo sapiens_hsa007900.65733410
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.65681491
99Endometrial cancer_Homo sapiens_hsa052130.64782338
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.63554414
101Phagosome_Homo sapiens_hsa041450.63348741
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.62474933
103Non-small cell lung cancer_Homo sapiens_hsa052230.61190108
104Fructose and mannose metabolism_Homo sapiens_hsa000510.60517158
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60297001
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60129702
107Prion diseases_Homo sapiens_hsa050200.59980600
108Prolactin signaling pathway_Homo sapiens_hsa049170.59119994
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.58664243
110Insulin resistance_Homo sapiens_hsa049310.58331404
111B cell receptor signaling pathway_Homo sapiens_hsa046620.56078413
112ErbB signaling pathway_Homo sapiens_hsa040120.56073309
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53170650
114Glioma_Homo sapiens_hsa052140.53066504
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.52805584
116Salmonella infection_Homo sapiens_hsa051320.52127905
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.51735125
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50649493
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.50379519
120Inositol phosphate metabolism_Homo sapiens_hsa005620.49666085
121Viral carcinogenesis_Homo sapiens_hsa052030.49161200
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48554243
123Insulin signaling pathway_Homo sapiens_hsa049100.46613538
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46497873
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45532171
126Sulfur relay system_Homo sapiens_hsa041220.44968143
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42379654
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41919214
129Pentose phosphate pathway_Homo sapiens_hsa000300.38655101
130Glutathione metabolism_Homo sapiens_hsa004800.36028678
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32470884
132Adherens junction_Homo sapiens_hsa045200.32098813
133Linoleic acid metabolism_Homo sapiens_hsa005910.27332023
134Pancreatic secretion_Homo sapiens_hsa049720.24781511
135Salivary secretion_Homo sapiens_hsa049700.24695818
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23807957
137AMPK signaling pathway_Homo sapiens_hsa041520.23213668
138Ovarian steroidogenesis_Homo sapiens_hsa049130.22363069
139Renal cell carcinoma_Homo sapiens_hsa052110.21549111
140Glucagon signaling pathway_Homo sapiens_hsa049220.20799053
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20408115
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20398931
143Choline metabolism in cancer_Homo sapiens_hsa052310.19896339
144Protein digestion and absorption_Homo sapiens_hsa049740.18845162
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17119709
146Lysosome_Homo sapiens_hsa041420.16047920
147Estrogen signaling pathway_Homo sapiens_hsa049150.15220977
148Tight junction_Homo sapiens_hsa045300.13830502
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.13817124
150Thyroid hormone synthesis_Homo sapiens_hsa049180.13404088
151Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13147603
152Bladder cancer_Homo sapiens_hsa052190.12901453
153Type II diabetes mellitus_Homo sapiens_hsa049300.12835005
154VEGF signaling pathway_Homo sapiens_hsa043700.09732825
155ECM-receptor interaction_Homo sapiens_hsa045120.09635292
156Hepatitis C_Homo sapiens_hsa051600.09342640
157Metabolic pathways_Homo sapiens_hsa011000.09147571
158Proteoglycans in cancer_Homo sapiens_hsa052050.08491215
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.08436666

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