SLC30A10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.68075523
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.62532926
3L-phenylalanine catabolic process (GO:0006559)6.42876369
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.42876369
5epoxygenase P450 pathway (GO:0019373)6.19201737
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.06220544
7L-phenylalanine metabolic process (GO:0006558)6.06220544
8aromatic amino acid family catabolic process (GO:0009074)5.88390315
9tryptophan catabolic process (GO:0006569)5.49235889
10indole-containing compound catabolic process (GO:0042436)5.49235889
11indolalkylamine catabolic process (GO:0046218)5.49235889
12high-density lipoprotein particle remodeling (GO:0034375)5.47717572
13alpha-linolenic acid metabolic process (GO:0036109)5.42672089
14omega-hydroxylase P450 pathway (GO:0097267)5.39075907
15bile acid biosynthetic process (GO:0006699)5.38440829
16kynurenine metabolic process (GO:0070189)5.34857336
17cysteine metabolic process (GO:0006534)5.14046238
18tryptophan metabolic process (GO:0006568)5.11832383
19reverse cholesterol transport (GO:0043691)5.11392525
20regulation of cholesterol esterification (GO:0010872)5.04572417
21urea cycle (GO:0000050)4.98791124
22urea metabolic process (GO:0019627)4.98791124
23glyoxylate metabolic process (GO:0046487)4.94395396
24protein-lipid complex remodeling (GO:0034368)4.93937202
25macromolecular complex remodeling (GO:0034367)4.93937202
26plasma lipoprotein particle remodeling (GO:0034369)4.93937202
27positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.93484669
28regulation of protein activation cascade (GO:2000257)4.92963033
29negative regulation of fibrinolysis (GO:0051918)4.82274411
30sulfur amino acid catabolic process (GO:0000098)4.78968974
31regulation of fibrinolysis (GO:0051917)4.77038538
32complement activation, alternative pathway (GO:0006957)4.76427289
33phospholipid efflux (GO:0033700)4.74084197
34drug metabolic process (GO:0017144)4.73225961
35regulation of triglyceride catabolic process (GO:0010896)4.64009284
36low-density lipoprotein particle remodeling (GO:0034374)4.60763349
37regulation of complement activation (GO:0030449)4.57669111
38bile acid metabolic process (GO:0008206)4.57527213
39negative regulation of lipase activity (GO:0060192)4.55569693
40regulation of plasminogen activation (GO:0010755)4.54529592
41nitrogen cycle metabolic process (GO:0071941)4.54070079
42negative regulation of cholesterol transport (GO:0032375)4.52617813
43negative regulation of sterol transport (GO:0032372)4.52617813
44serine family amino acid catabolic process (GO:0009071)4.49056895
45oxidative demethylation (GO:0070989)4.47791989
46protein carboxylation (GO:0018214)4.47326424
47peptidyl-glutamic acid carboxylation (GO:0017187)4.47326424
48plasma lipoprotein particle assembly (GO:0034377)4.47058623
49very-low-density lipoprotein particle assembly (GO:0034379)4.46159238
50hormone catabolic process (GO:0042447)4.41503721
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40064114
52phenylpropanoid metabolic process (GO:0009698)4.39124332
53glutamate metabolic process (GO:0006536)4.37281553
54homocysteine metabolic process (GO:0050667)4.34803248
55acylglycerol homeostasis (GO:0055090)4.23153705
56triglyceride homeostasis (GO:0070328)4.23153705
57cholesterol efflux (GO:0033344)4.22691718
58negative regulation of hemostasis (GO:1900047)4.21850364
59negative regulation of blood coagulation (GO:0030195)4.21850364
60aromatic amino acid family metabolic process (GO:0009072)4.18812705
61bile acid and bile salt transport (GO:0015721)4.18130837
62amino-acid betaine metabolic process (GO:0006577)4.17724195
63dicarboxylic acid biosynthetic process (GO:0043650)4.15260084
64cellular ketone body metabolic process (GO:0046950)4.14431161
65alpha-amino acid catabolic process (GO:1901606)4.11126422
66cellular glucuronidation (GO:0052695)4.03107084
67lysine metabolic process (GO:0006553)4.02867460
68lysine catabolic process (GO:0006554)4.02867460
69plasma lipoprotein particle organization (GO:0071827)4.01873815
70ethanol oxidation (GO:0006069)3.97313327
71coenzyme catabolic process (GO:0009109)3.96373407
72cellular modified amino acid catabolic process (GO:0042219)3.96076379
73tyrosine metabolic process (GO:0006570)3.95799172
74protein-lipid complex assembly (GO:0065005)3.94523377
75proline metabolic process (GO:0006560)3.94283055
76plasma lipoprotein particle clearance (GO:0034381)3.92255676
77cellular biogenic amine catabolic process (GO:0042402)3.87394996
78amine catabolic process (GO:0009310)3.87394996
79negative regulation of coagulation (GO:0050819)3.85786037
80indolalkylamine metabolic process (GO:0006586)3.83135480
81regulation of cholesterol homeostasis (GO:2000188)3.82755169
82imidazole-containing compound metabolic process (GO:0052803)3.82322290
83cellular amino acid catabolic process (GO:0009063)3.82012823
84S-adenosylmethionine metabolic process (GO:0046500)3.78066867
85protein-lipid complex subunit organization (GO:0071825)3.74284628
86heme transport (GO:0015886)3.73848121
87negative regulation of wound healing (GO:0061045)3.72928041
88phospholipid homeostasis (GO:0055091)3.69181697
89short-chain fatty acid metabolic process (GO:0046459)3.67126574
90ethanol metabolic process (GO:0006067)3.66773173
91flavonoid metabolic process (GO:0009812)3.65828820
92regulation of bile acid biosynthetic process (GO:0070857)3.65452325
93regulation of cholesterol biosynthetic process (GO:0045540)3.64053324
94glycine metabolic process (GO:0006544)3.63986406
95serine family amino acid metabolic process (GO:0009069)3.63702556
96drug catabolic process (GO:0042737)3.63274752
97positive regulation of hemostasis (GO:1900048)3.62056627
98positive regulation of blood coagulation (GO:0030194)3.62056627
99regulation of humoral immune response (GO:0002920)3.61631957
100intestinal cholesterol absorption (GO:0030299)3.60420613
101arginine metabolic process (GO:0006525)3.57918219
102positive regulation of lipoprotein lipase activity (GO:0051006)3.57228717
103positive regulation of triglyceride lipase activity (GO:0061365)3.57228717
104ketone body metabolic process (GO:1902224)3.56503390
105glucuronate metabolic process (GO:0019585)3.52900022
106uronic acid metabolic process (GO:0006063)3.52900022
107cholesterol homeostasis (GO:0042632)3.52834322
108serine family amino acid biosynthetic process (GO:0009070)3.51999436
109positive regulation of lipid catabolic process (GO:0050996)3.50109925
110lipoprotein metabolic process (GO:0042157)3.48619394
111benzene-containing compound metabolic process (GO:0042537)3.47245748
112sterol homeostasis (GO:0055092)3.46986138
113complement activation, classical pathway (GO:0006958)3.41983575
114cholesterol transport (GO:0030301)3.40732148
115sterol transport (GO:0015918)3.40732148
116sodium-independent organic anion transport (GO:0043252)3.40488109
117alkaloid metabolic process (GO:0009820)3.40072033
118protein activation cascade (GO:0072376)3.39904724
119fibrinolysis (GO:0042730)3.39606757
120glutamine family amino acid biosynthetic process (GO:0009084)3.39006738
121regulation of cholesterol metabolic process (GO:0090181)3.39000796
122acute-phase response (GO:0006953)3.38775998
123cytolysis (GO:0019835)3.38186585
124blood coagulation, intrinsic pathway (GO:0007597)3.37180983
125urate metabolic process (GO:0046415)3.36667598
126negative regulation of protein activation cascade (GO:2000258)3.35990047
127positive regulation of coagulation (GO:0050820)3.33791616
128complement activation (GO:0006956)3.33492676

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse6.87911175
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.91408761
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.62309248
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.47766686
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.64036694
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.70196313
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.59741424
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.46725366
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87702616
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.76130159
11IGF1R_20145208_ChIP-Seq_DFB_Human2.00213603
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0954085
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.87835681
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84787273
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80180808
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72310153
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.58110083
18ER_23166858_ChIP-Seq_MCF-7_Human1.57419123
19HTT_18923047_ChIP-ChIP_STHdh_Human1.54800950
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53406759
21GATA1_22025678_ChIP-Seq_K562_Human1.47809854
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45601077
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.34594729
24VDR_22108803_ChIP-Seq_LS180_Human1.33810534
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30327009
26ZNF274_21170338_ChIP-Seq_K562_Hela1.29304801
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28876383
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28794701
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25956964
30KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21992833
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21963019
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21436071
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19767056
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19193949
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19180835
36* STAT3_23295773_ChIP-Seq_U87_Human1.16861582
37TP53_16413492_ChIP-PET_HCT116_Human1.14447908
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13965335
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11339083
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11319943
41* EZH2_27294783_Chip-Seq_NPCs_Mouse1.11312137
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11141356
43* PHF8_20622853_ChIP-Seq_HELA_Human1.10667987
44CDX2_22108803_ChIP-Seq_LS180_Human1.09480763
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.09232680
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09166023
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08221704
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08079014
49TCF4_22108803_ChIP-Seq_LS180_Human1.06144159
50* HNFA_21074721_ChIP-Seq_CACO-2_Human1.04969808
51SMAD4_21799915_ChIP-Seq_A2780_Human1.04440742
52* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.04362680
53* NFYA_21822215_ChIP-Seq_K562_Human1.04205249
54SOX2_19829295_ChIP-Seq_ESCs_Human1.02881599
55NANOG_19829295_ChIP-Seq_ESCs_Human1.02881599
56GBX2_23144817_ChIP-Seq_PC3_Human1.02838368
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02055066
58FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01281023
59* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00200710
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99861869
61KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99613870
62EED_16625203_ChIP-ChIP_MESCs_Mouse0.98813731
63CLOCK_20551151_ChIP-Seq_293T_Human0.98677620
64* TCF4_23295773_ChIP-Seq_U87_Human0.98333307
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98294121
66* TCF4_18268006_ChIP-ChIP_LS174T_Human0.98103293
67* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.98090405
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97879397
69* NFE2_27457419_Chip-Seq_LIVER_Mouse0.97815241
70* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97064875
71* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96831254
72FOXA1_25552417_ChIP-Seq_VCAP_Human0.96226405
73CBP_20019798_ChIP-Seq_JUKART_Human0.95919767
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95919767
75* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95369528
76TP53_18474530_ChIP-ChIP_U2OS_Human0.95291522
77* GATA1_19941826_ChIP-Seq_K562_Human0.94714305
78* ETV1_20927104_ChIP-Seq_GIST48_Human0.94102888
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94023737
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93629016
81* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93141945
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90949455
83* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.88952285
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88621880
85JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88514825
86FUS_26573619_Chip-Seq_HEK293_Human0.86790108
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86354669
88SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85975716
89* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85486618
90CBP_21632823_ChIP-Seq_H3396_Human0.85460153
91SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.85248032
92* GATA1_19941827_ChIP-Seq_MEL_Mouse0.84874117
93* SMAD3_21741376_ChIP-Seq_EPCs_Human0.84844642
94CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84497873
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84171329
96* CRX_20693478_ChIP-Seq_RETINA_Mouse0.84166967
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.84103121
98* AR_20517297_ChIP-Seq_VCAP_Human0.83765479
99* NFYB_21822215_ChIP-Seq_K562_Human0.82908011
100DROSHA_22980978_ChIP-Seq_HELA_Human0.82705681
101* GATA6_21074721_ChIP-Seq_CACO-2_Human0.82168638
102AR_21572438_ChIP-Seq_LNCaP_Human0.81844173
103* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.81801297
104ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81139443
105OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81031031
106* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80692860
107* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80692860
108RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80530183
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.80046898
110REST_21632747_ChIP-Seq_MESCs_Mouse0.80035273
111* TBL1_22424771_ChIP-Seq_293T_Human0.79932706
112CEBPB_22108803_ChIP-Seq_LS180_Human0.79891661
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.78680389
114* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77994285
115* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77994285
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.76810505
117CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75587746
118* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74315417
119AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74161010
120TAF15_26573619_Chip-Seq_HEK293_Human0.73814694
121* EZH2_27294783_Chip-Seq_ESCs_Mouse0.73534920
122ESR2_21235772_ChIP-Seq_MCF-7_Human0.73054325
123* BCAT_22108803_ChIP-Seq_LS180_Human0.72964522
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.72913622
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72826044
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.72319992
127* GATA2_19941826_ChIP-Seq_K562_Human0.72301003
128IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72240903
129STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71280202
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69015059
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68219157
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.64666929
133GATA4_25053715_ChIP-Seq_YYC3_Human0.64384969
134MYC_19915707_ChIP-ChIP_AK7_Human0.63781991
135* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.62916070
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.62667051
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62020033
138KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.61468717
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.60622425
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.60191222
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59938536
142AR_25329375_ChIP-Seq_VCAP_Human0.58323760
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.58100503
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.57900228
145* MYC_27129775_Chip-Seq_CORNEA_Mouse0.57721385
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57345333
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.57092410
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.56980014
149RXR_22108803_ChIP-Seq_LS180_Human0.56692973
150CTBP2_25329375_ChIP-Seq_LNCAP_Human0.56592625
151SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56293682
152* P300_19829295_ChIP-Seq_ESCs_Human0.56123029
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.55899855
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.55788988
155* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.55530947
156CTCF_27219007_Chip-Seq_Bcells_Human0.55430237
157RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.55395700
158* SOX2_21211035_ChIP-Seq_LN229_Gbm0.55131014
159TAF2_19829295_ChIP-Seq_ESCs_Human0.54700926
160SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.54509504
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53765146
162* LXR_22292898_ChIP-Seq_THP-1_Human0.53591716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82598114
2MP0005360_urolithiasis7.62474977
3MP0005085_abnormal_gallbladder_physiolo6.09876612
4MP0005365_abnormal_bile_salt5.54303976
5MP0008875_abnormal_xenobiotic_pharmacok4.73417790
6MP0003806_abnormal_nucleotide_metabolis3.95106546
7MP0010329_abnormal_lipoprotein_level3.70334273
8MP0003252_abnormal_bile_duct3.67286624
9MP0009840_abnormal_foam_cell3.23013870
10MP0001666_abnormal_nutrient_absorption2.92820528
11MP0005083_abnormal_biliary_tract2.87183296
12MP0005332_abnormal_amino_acid2.57693514
13MP0002822_catalepsy2.31534530
14MP0003195_calcinosis2.20224898
15MP0000566_synostosis2.19622405
16MP0003656_abnormal_erythrocyte_physiolo2.10189555
17MP0002118_abnormal_lipid_homeostasis2.07725417
18MP0003191_abnormal_cellular_cholesterol2.02147972
19MP0004019_abnormal_vitamin_homeostasis2.00555982
20MP0000609_abnormal_liver_physiology1.92690930
21MP0003868_abnormal_feces_composition1.70085318
22MP0009697_abnormal_copulation1.64099763
23MP0005408_hypopigmentation1.60365787
24MP0005584_abnormal_enzyme/coenzyme_acti1.56119749
25MP0002254_reproductive_system_inflammat1.54395392
26MP0005319_abnormal_enzyme/_coenzyme1.52941850
27MP0004147_increased_porphyrin_level1.50965018
28MP0003011_delayed_dark_adaptation1.50428458
29MP0001764_abnormal_homeostasis1.42890976
30MP0003122_maternal_imprinting1.41809220
31MP0003690_abnormal_glial_cell1.35975252
32MP0000604_amyloidosis1.27571989
33MP0003329_amyloid_beta_deposits1.19471307
34MP0002138_abnormal_hepatobiliary_system1.19286867
35MP0005647_abnormal_sex_gland1.15032533
36MP0009384_cardiac_valve_regurgitation1.06537207
37MP0005636_abnormal_mineral_homeostasis1.00957895
38MP0009764_decreased_sensitivity_to0.97741560
39MP0009643_abnormal_urine_homeostasis0.97484953
40MP0005167_abnormal_blood-brain_barrier0.95818442
41MP0003718_maternal_effect0.95231884
42MP0002132_abnormal_respiratory_system0.92211816
43MP0002282_abnormal_trachea_morphology0.91141278
44MP0001984_abnormal_olfaction0.90719680
45MP0002876_abnormal_thyroid_physiology0.87539383
46MP0003705_abnormal_hypodermis_morpholog0.85269385
47MP0000598_abnormal_liver_morphology0.85172901
48MP0009780_abnormal_chondrocyte_physiolo0.85150010
49MP0005535_abnormal_body_temperature0.84643136
50MP0005646_abnormal_pituitary_gland0.84240744
51MP0005084_abnormal_gallbladder_morpholo0.80895927
52MP0005395_other_phenotype0.79580376
53MP0005410_abnormal_fertilization0.79384742
54MP0001915_intracranial_hemorrhage0.79175377
55MP0009642_abnormal_blood_homeostasis0.78361897
56MP0005187_abnormal_penis_morphology0.77166858
57MP0003075_altered_response_to0.76858662
58MP0003186_abnormal_redox_activity0.75500941
59MP0005376_homeostasis/metabolism_phenot0.75460580
60MP0009763_increased_sensitivity_to0.74142900
61MP0002078_abnormal_glucose_homeostasis0.73993340
62MP0001986_abnormal_taste_sensitivity0.73869523
63MP0005451_abnormal_body_composition0.73132550
64MP0005448_abnormal_energy_balance0.70354561
65MP0004130_abnormal_muscle_cell0.68479349
66MP0008872_abnormal_physiological_respon0.68478048
67MP0002971_abnormal_brown_adipose0.68230534
68MP0010368_abnormal_lymphatic_system0.64004742
69MP0005645_abnormal_hypothalamus_physiol0.63988023
70MP0001440_abnormal_grooming_behavior0.62011662
71MP0006036_abnormal_mitochondrial_physio0.59600634
72MP0005166_decreased_susceptibility_to0.59382639
73MP0005334_abnormal_fat_pad0.58931847
74MP0000639_abnormal_adrenal_gland0.58799772
75MP0003633_abnormal_nervous_system0.58228699
76MP0005266_abnormal_metabolism0.58149893
77MP0004859_abnormal_synaptic_plasticity0.56870712
78MP0009765_abnormal_xenobiotic_induced0.56414042
79MP0004885_abnormal_endolymph0.55911890
80MP0003890_abnormal_embryonic-extraembry0.55687120
81MP0008469_abnormal_protein_level0.55045261
82MP0003567_abnormal_fetal_cardiomyocyte0.54620497
83MP0008874_decreased_physiological_sensi0.53402712
84MP0005670_abnormal_white_adipose0.53059572
85MP0004043_abnormal_pH_regulation0.52715477
86MP0009053_abnormal_anal_canal0.52175705
87MP0003136_yellow_coat_color0.51958491
88MP0004858_abnormal_nervous_system0.51400697
89MP0002938_white_spotting0.50555146
90MP0009745_abnormal_behavioral_response0.50491738
91MP0002249_abnormal_larynx_morphology0.48689380
92MP0001486_abnormal_startle_reflex0.48625095
93MP0003953_abnormal_hormone_level0.47821283
94MP0001661_extended_life_span0.47607957
95MP0001324_abnormal_eye_pigmentation0.46913387
96MP0002168_other_aberrant_phenotype0.46790273
97MP0003635_abnormal_synaptic_transmissio0.46288907
98MP0005551_abnormal_eye_electrophysiolog0.44222143
99MP0002736_abnormal_nociception_after0.44069086
100MP0001529_abnormal_vocalization0.43110854
101MP0009672_abnormal_birth_weight0.42799810
102MP0003631_nervous_system_phenotype0.42353243
103MP0005220_abnormal_exocrine_pancreas0.41830112
104MP0002063_abnormal_learning/memory/cond0.41557927
105MP0003638_abnormal_response/metabolism_0.41389587
106MP0001177_atelectasis0.41316915
107MP0003632_abnormal_nervous_system0.41221092
108MP0004142_abnormal_muscle_tone0.40742265
109MP0002090_abnormal_vision0.40715887
110MP0006035_abnormal_mitochondrial_morpho0.38890873
111MP0002909_abnormal_adrenal_gland0.38533275
112MP0002064_seizures0.38429100
113MP0005386_behavior/neurological_phenoty0.38203227
114MP0004924_abnormal_behavior0.38203227
115MP0005595_abnormal_vascular_smooth0.38177277
116MP0004270_analgesia0.38150867
117MP0002069_abnormal_eating/drinking_beha0.37826233
118MP0001501_abnormal_sleep_pattern0.37736647
119MP0006292_abnormal_olfactory_placode0.37723878
120MP0003698_abnormal_male_reproductive0.37663523
121MP0003879_abnormal_hair_cell0.37560219
122MP0002572_abnormal_emotion/affect_behav0.37140334
123MP0000230_abnormal_systemic_arterial0.37058640
124MP0001502_abnormal_circadian_rhythm0.36916765
125MP0005164_abnormal_response_to0.36824416
126MP0004883_abnormal_blood_vessel0.36569417
127MP0002796_impaired_skin_barrier0.36401001
128MP0001929_abnormal_gametogenesis0.36332461
129MP0005248_abnormal_Harderian_gland0.36291493
130MP0000920_abnormal_myelination0.35478812
131MP0003699_abnormal_female_reproductive0.35389290
132MP0002229_neurodegeneration0.34805892
133MP0001756_abnormal_urination0.34500062
134MP0009115_abnormal_fat_cell0.33558381
135MP0002089_abnormal_postnatal_growth/wei0.33404846
136MP0003943_abnormal_hepatobiliary_system0.33331094
137MP0002928_abnormal_bile_duct0.32913600

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.23869435
2Deep venous thrombosis (HP:0002625)6.67551767
3Hypobetalipoproteinemia (HP:0003563)6.23987369
4Xanthomatosis (HP:0000991)6.22335384
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.19050877
6Prolonged partial thromboplastin time (HP:0003645)6.04865688
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.85850600
8Hyperlipoproteinemia (HP:0010980)5.60704501
9Complement deficiency (HP:0004431)5.07461936
10Hypolipoproteinemia (HP:0010981)4.93776961
11Acanthocytosis (HP:0001927)4.46534861
12Hypoalphalipoproteinemia (HP:0003233)4.46010548
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.36354115
14Epidermoid cyst (HP:0200040)4.29795221
15Hyperglycinemia (HP:0002154)4.26618184
16Hyperammonemia (HP:0001987)4.18461688
17Joint hemorrhage (HP:0005261)4.15342869
18Fat malabsorption (HP:0002630)4.11154129
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.05193958
20Abnormality of the common coagulation pathway (HP:0010990)4.02553442
21Abnormality of glutamine family amino acid metabolism (HP:0010902)3.95829377
22Hyperglycinuria (HP:0003108)3.93072487
23Abnormality of glycine metabolism (HP:0010895)3.88630965
24Abnormality of serine family amino acid metabolism (HP:0010894)3.88630965
25Hyperbilirubinemia (HP:0002904)3.84699766
26Ketosis (HP:0001946)3.82745791
27Conjugated hyperbilirubinemia (HP:0002908)3.78931352
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.78250800
29Hypochromic microcytic anemia (HP:0004840)3.72429634
30Poikilocytosis (HP:0004447)3.70265040
31Abnormality of methionine metabolism (HP:0010901)3.68839998
32Abnormality of complement system (HP:0005339)3.55574721
33Hypoglycemic coma (HP:0001325)3.52316540
34Hypercholesterolemia (HP:0003124)3.51683016
35Abnormality of the intrinsic pathway (HP:0010989)3.12285298
36Generalized aminoaciduria (HP:0002909)3.07383872
37Spontaneous abortion (HP:0005268)3.05790282
38Cholelithiasis (HP:0001081)3.04703093
39Abnormal gallbladder morphology (HP:0012437)3.03221669
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.95356459
41Ketoacidosis (HP:0001993)2.93829790
42Steatorrhea (HP:0002570)2.89470130
43Osteomalacia (HP:0002749)2.86059901
44Delayed CNS myelination (HP:0002188)2.85553249
45Cholecystitis (HP:0001082)2.84448708
46Abnormal gallbladder physiology (HP:0012438)2.84448708
47Abnormality of pyrimidine metabolism (HP:0004353)2.82607404
48Abnormality of fatty-acid metabolism (HP:0004359)2.81467912
49Hepatocellular carcinoma (HP:0001402)2.81177925
50Nephritis (HP:0000123)2.79464770
51Reticulocytosis (HP:0001923)2.72102776
52Metabolic acidosis (HP:0001942)2.69246205
53Hypoglycemic seizures (HP:0002173)2.67691463
54Myocardial infarction (HP:0001658)2.62478551
55Abnormality of serum amino acid levels (HP:0003112)2.62281610
56Abnormality of the gallbladder (HP:0005264)2.61460491
57Increased serum pyruvate (HP:0003542)2.61421687
58Confusion (HP:0001289)2.55181617
59Status epilepticus (HP:0002133)2.55127693
60Abnormality of nucleobase metabolism (HP:0010932)2.50500180
61Skin nodule (HP:0200036)2.50479439
62Abnormality of urine glucose concentration (HP:0011016)2.49161167
63Glycosuria (HP:0003076)2.49161167
64Abnormality of glycolysis (HP:0004366)2.46534712
65Vascular calcification (HP:0004934)2.41255715
66Malnutrition (HP:0004395)2.40752720
67Amyloidosis (HP:0011034)2.38516577
68Abnormality of the heme biosynthetic pathway (HP:0010472)2.35370286
69Bifid scrotum (HP:0000048)2.34845785
70Abnormality of purine metabolism (HP:0004352)2.34446568
71Lethargy (HP:0001254)2.23007901
72Systemic lupus erythematosus (HP:0002725)2.22690298
73Gout (HP:0001997)2.20413702
74Dicarboxylic aciduria (HP:0003215)2.18119965
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18119965
76Late onset (HP:0003584)2.16724957
77Neonatal onset (HP:0003623)2.14043890
78Brushfield spots (HP:0001088)2.11856749
79Enlarged kidneys (HP:0000105)2.11263983
80Mitral stenosis (HP:0001718)2.09368394
81Irritability (HP:0000737)2.09158101
82Hyperphosphaturia (HP:0003109)2.07749982
83Cardiovascular calcification (HP:0011915)2.07252705
84Arthropathy (HP:0003040)2.03563249
85Hyperinsulinemic hypoglycemia (HP:0000825)2.01736941
86Rickets (HP:0002748)1.99184591
87Fair hair (HP:0002286)1.98969347
88Facial shape deformation (HP:0011334)1.96899887
89Potter facies (HP:0002009)1.96899887
90Gingival bleeding (HP:0000225)1.95740346
91Hyperventilation (HP:0002883)1.95657091
92Spastic diplegia (HP:0001264)1.95265842
93Vomiting (HP:0002013)1.92987342
94Hydroxyprolinuria (HP:0003080)1.88992483
95Abnormality of proline metabolism (HP:0010907)1.88992483
96Glomerulonephritis (HP:0000099)1.88822764
97Esophageal varix (HP:0002040)1.88588541
98Thrombophlebitis (HP:0004418)1.82990088
99Bile duct proliferation (HP:0001408)1.79782504
100Abnormal biliary tract physiology (HP:0012439)1.79782504
101* Sensorimotor neuropathy (HP:0007141)1.79120884
102Pseudobulbar signs (HP:0002200)1.78951959
103Recurrent gram-negative bacterial infections (HP:0005420)1.78403337
104Symptomatic seizures (HP:0011145)1.78205671
105Hypophosphatemic rickets (HP:0004912)1.77039387
106Cerebral edema (HP:0002181)1.76873822
107Abnormality of transition element cation homeostasis (HP:0011030)1.76817954
108Hemorrhage of the eye (HP:0011885)1.76688022
109Abnormality of vitamin metabolism (HP:0100508)1.76504913
110Hepatoblastoma (HP:0002884)1.76351576
111Abnormality of iron homeostasis (HP:0011031)1.75229335
112Pancreatitis (HP:0001733)1.75089836
113Back pain (HP:0003418)1.71214733
114Proximal tubulopathy (HP:0000114)1.70019870
115Chronic hepatic failure (HP:0100626)1.69859388
116Opisthotonus (HP:0002179)1.69760429
117Menorrhagia (HP:0000132)1.68520066
118Abnormality of alanine metabolism (HP:0010916)1.67654811
119Hyperalaninemia (HP:0003348)1.67654811
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67654811
121Neoplasm of the liver (HP:0002896)1.66425862
122Hypertriglyceridemia (HP:0002155)1.65683979
123Alacrima (HP:0000522)1.64384871
124Retinal atrophy (HP:0001105)1.62059390
125Abnormal urine phosphate concentration (HP:0012599)1.61238209
126Abnormal tarsal ossification (HP:0008369)1.59985957
127Megaloblastic anemia (HP:0001889)1.58921516
128Purpura (HP:0000979)1.52699342
129Renal cortical cysts (HP:0000803)1.51993080
130Pigmentary retinal degeneration (HP:0001146)1.48609078
131Abnormal delivery (HP:0001787)1.47461101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK14.39158989
2BCKDK4.33034398
3EPHA43.70349996
4PDK23.10904853
5FGFR42.87068283
6ERN12.78845060
7INSRR2.66873089
8ERBB42.66594800
9MAP2K42.47962889
10DAPK22.40153689
11PNCK2.34464822
12FGFR32.33734198
13EIF2AK12.32802780
14MST1R2.24698942
15MAP4K22.19112306
16TAOK32.13668511
17MAPK111.99096397
18NEK11.90379430
19WNK41.83307486
20LMTK21.80911348
21WNK31.80904716
22GRK61.78806206
23TNIK1.74470391
24ACVR1B1.69056704
25TBK11.56079172
26BCR1.55938827
27FRK1.51069596
28MAP3K41.50103667
29TRIB31.47175195
30MAPK121.45589896
31NTRK21.43272835
32SGK21.36852963
33TSSK61.35997596
34CCNB11.30843561
35RAF11.30259129
36PRKCG1.30136805
37SGK31.30060744
38PBK1.29501346
39EIF2AK31.26773666
40WEE11.26155996
41PHKG21.26035719
42PHKG11.26035719
43PRKAA21.24045904
44MAP3K71.23274384
45NTRK31.21663818
46MARK11.21464775
47PDPK11.21271270
48EPHA31.21053506
49FGFR21.19336244
50ERBB21.19296634
51FGFR11.15622112
52PLK41.14877148
53TAOK11.13810985
54SGK2231.10418420
55SGK4941.10418420
56PKN11.06677264
57PRKCZ1.04500112
58EPHB20.99402804
59MAPK70.98120055
60MAP2K70.96801187
61PRKACG0.96009396
62ZAK0.94790046
63BRSK20.94142998
64PINK10.93625524
65CAMK2G0.93430395
66PRKAA10.93038422
67SIK20.92325567
68ABL20.90991805
69CSNK1G10.90427343
70LATS10.87780380
71JAK20.87680730
72PTK60.85596853
73PIK3CG0.84943994
74CSNK1A1L0.84813262
75BMPR1B0.83880423
76MAPK40.80391249
77IKBKE0.79234246
78PDK10.78825505
79CAMKK10.78269917
80STK390.74280276
81AKT30.74113920
82TTK0.73236260
83CASK0.72503897
84TAOK20.70651589
85CAMK1G0.69592472
86MAPKAPK50.68969915
87MINK10.68667535
88KSR20.68483209
89CSNK1E0.66152319
90PRKACB0.64788060
91MAP3K130.64513580
92CSNK1D0.64447356
93CAMK1D0.64063927
94MET0.63561401
95PRKCA0.62689755
96ICK0.62422509
97PIK3CA0.62036272
98TYRO30.61911056
99MAP2K10.61585695
100CSNK1G30.61577507
101PKN20.61466377
102DYRK20.60420120
103CSNK1A10.59757988
104IRAK30.58476730
105PRKCQ0.58387276
106IGF1R0.57780744
107RPS6KA30.56014505
108CAMK2A0.55906725
109CDK50.55559725
110PAK30.53298080
111ARAF0.52643280
112CLK10.52455662
113CSNK1G20.51897116
114FER0.51357653
115MAPKAPK30.50495599
116STK110.50393196
117TYK20.48728367
118PRKCB0.48309769
119PRKCE0.48100510
120RET0.47731128
121SGK10.46690287
122MAPK150.46609527
123PLK20.46507901
124GRK10.45454302
125MAP3K20.45344816
126BMX0.43838994
127STK38L0.43813776
128KSR10.43424222
129MAP3K100.42931739
130WNK10.42094114
131DAPK10.41909100
132NTRK10.41835488
133MAP2K60.41152112
134SRPK10.40573915
135CSNK2A10.40434286
136RPS6KB10.39968486
137NEK20.39335592
138CDK60.39029533
139KDR0.38897749
140MAP3K120.38828336
141JAK10.38681655
142RIPK10.37883173
143PRKACA0.37545167
144MAPK130.37320796
145DYRK30.37075231
146CSNK2A20.36968863
147PTK20.36850684
148PRKG10.36164339
149DYRK1B0.35241282
150MAP3K10.35055764

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.32904995
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.25514580
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00673583
4Arginine biosynthesis_Homo sapiens_hsa002202.90954817
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84675911
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65287540
7Complement and coagulation cascades_Homo sapiens_hsa046102.59210934
8Fatty acid degradation_Homo sapiens_hsa000712.51785866
9Tryptophan metabolism_Homo sapiens_hsa003802.51046815
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47228269
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33029245
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.17164673
13Butanoate metabolism_Homo sapiens_hsa006502.16079902
14PPAR signaling pathway_Homo sapiens_hsa033201.96490924
15Fatty acid metabolism_Homo sapiens_hsa012121.91947171
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91862975
17Bile secretion_Homo sapiens_hsa049761.90661963
18Peroxisome_Homo sapiens_hsa041461.90475182
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89309566
20Propanoate metabolism_Homo sapiens_hsa006401.81113129
21Histidine metabolism_Homo sapiens_hsa003401.77356423
22Chemical carcinogenesis_Homo sapiens_hsa052041.74943527
23Caffeine metabolism_Homo sapiens_hsa002321.74686094
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73692704
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.70474692
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65973808
27Sulfur metabolism_Homo sapiens_hsa009201.62449690
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59985391
29beta-Alanine metabolism_Homo sapiens_hsa004101.56600551
30Retinol metabolism_Homo sapiens_hsa008301.53069285
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50952258
32Steroid biosynthesis_Homo sapiens_hsa001001.48448296
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.45937319
34Fat digestion and absorption_Homo sapiens_hsa049751.45199005
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43550085
36Staphylococcus aureus infection_Homo sapiens_hsa051501.40386556
37Starch and sucrose metabolism_Homo sapiens_hsa005001.38192199
38ABC transporters_Homo sapiens_hsa020101.37722847
39Vitamin B6 metabolism_Homo sapiens_hsa007501.35692367
40Phenylalanine metabolism_Homo sapiens_hsa003601.32345356
41Selenocompound metabolism_Homo sapiens_hsa004501.28336809
42Pyruvate metabolism_Homo sapiens_hsa006201.27383212
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26323674
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25062683
45Tyrosine metabolism_Homo sapiens_hsa003501.25036802
46Fatty acid biosynthesis_Homo sapiens_hsa000611.19942324
47Vitamin digestion and absorption_Homo sapiens_hsa049771.15500688
48Fatty acid elongation_Homo sapiens_hsa000621.14512321
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11793527
50Sulfur relay system_Homo sapiens_hsa041221.11561215
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08780268
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07702949
53Biosynthesis of amino acids_Homo sapiens_hsa012301.04820140
54Carbon metabolism_Homo sapiens_hsa012001.01993499
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.98854966
56Folate biosynthesis_Homo sapiens_hsa007900.96875584
57Arginine and proline metabolism_Homo sapiens_hsa003300.91095662
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.82314830
59Glycerolipid metabolism_Homo sapiens_hsa005610.80308571
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79619882
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74982949
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74114979
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73869404
64Lysine degradation_Homo sapiens_hsa003100.73324162
65Galactose metabolism_Homo sapiens_hsa000520.51154499
66Glutathione metabolism_Homo sapiens_hsa004800.49727592
67Pentose phosphate pathway_Homo sapiens_hsa000300.48009954
68Fructose and mannose metabolism_Homo sapiens_hsa000510.44949129
69Metabolic pathways_Homo sapiens_hsa011000.42035375
70Prion diseases_Homo sapiens_hsa050200.40533551
71One carbon pool by folate_Homo sapiens_hsa006700.39255056
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.37919053
73Mineral absorption_Homo sapiens_hsa049780.36205586
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30824086
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.30012666
76GABAergic synapse_Homo sapiens_hsa047270.24833013
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.22633060
78Insulin resistance_Homo sapiens_hsa049310.20880820
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19390084
80Sphingolipid metabolism_Homo sapiens_hsa006000.18739997
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18529993
82Glucagon signaling pathway_Homo sapiens_hsa049220.16862887
83Nicotine addiction_Homo sapiens_hsa050330.14401506
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08299684
85Ether lipid metabolism_Homo sapiens_hsa005650.08220136
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04059881
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03356891
88Other glycan degradation_Homo sapiens_hsa005110.03103492
89Renin-angiotensin system_Homo sapiens_hsa046140.02994291
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02722679
91African trypanosomiasis_Homo sapiens_hsa051430.02009714
92Thyroid hormone synthesis_Homo sapiens_hsa049180.01287784
93Morphine addiction_Homo sapiens_hsa05032-0.1202149
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1108111
95Retrograde endocannabinoid signaling_Homo sapiens_hsa04723-0.1097835
96Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1065346
97Protein export_Homo sapiens_hsa03060-0.0886401
98Circadian rhythm_Homo sapiens_hsa04710-0.0878304
99Insulin signaling pathway_Homo sapiens_hsa04910-0.0838040
100N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0692546
101Type II diabetes mellitus_Homo sapiens_hsa04930-0.0680929
102Pertussis_Homo sapiens_hsa05133-0.0659469
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0642075
104Cocaine addiction_Homo sapiens_hsa05030-0.0412398
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0270658
106Serotonergic synapse_Homo sapiens_hsa04726-0.0199815
107AMPK signaling pathway_Homo sapiens_hsa04152-0.0164561
108Glutamatergic synapse_Homo sapiens_hsa04724-0.0141517
109Insulin secretion_Homo sapiens_hsa04911-0.0131633
110Salivary secretion_Homo sapiens_hsa04970-0.0103404
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0039669
112Linoleic acid metabolism_Homo sapiens_hsa00591-0.0034545

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