SLC30A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.22852165
2glutamate secretion (GO:0014047)5.85094503
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.67201056
4synaptic vesicle exocytosis (GO:0016079)5.60083295
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.59344839
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.52330254
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.27965190
8vocalization behavior (GO:0071625)5.09244125
9synaptic vesicle maturation (GO:0016188)5.03978766
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.96713779
11regulation of glutamate receptor signaling pathway (GO:1900449)4.96160460
12protein localization to synapse (GO:0035418)4.95683326
13glutamate receptor signaling pathway (GO:0007215)4.77772796
14regulation of synaptic vesicle exocytosis (GO:2000300)4.76079020
15neuronal action potential propagation (GO:0019227)4.69304267
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.69194879
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.64634928
18regulation of synaptic vesicle transport (GO:1902803)4.64425707
19synaptic transmission, glutamatergic (GO:0035249)4.63893011
20regulation of neuronal synaptic plasticity (GO:0048168)4.60443760
21locomotory exploration behavior (GO:0035641)4.53834249
22neuron cell-cell adhesion (GO:0007158)4.38324760
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.26504510
24neurotransmitter-gated ion channel clustering (GO:0072578)4.25655087
25neuron-neuron synaptic transmission (GO:0007270)4.21657568
26exploration behavior (GO:0035640)4.15367686
27gamma-aminobutyric acid signaling pathway (GO:0007214)4.11135278
28synaptic vesicle endocytosis (GO:0048488)4.07852143
29regulation of synaptic plasticity (GO:0048167)4.00235349
30positive regulation of synapse maturation (GO:0090129)3.97638907
31long-term synaptic potentiation (GO:0060291)3.92908252
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.92737924
33piRNA metabolic process (GO:0034587)3.91360828
34L-amino acid import (GO:0043092)3.85839054
35behavioral fear response (GO:0001662)3.84826258
36behavioral defense response (GO:0002209)3.84826258
37G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80900771
38neurotransmitter secretion (GO:0007269)3.80507799
39regulation of postsynaptic membrane potential (GO:0060078)3.71988649
40positive regulation of membrane potential (GO:0045838)3.71329100
41long-term memory (GO:0007616)3.66887444
42regulation of voltage-gated calcium channel activity (GO:1901385)3.65768959
43proline transport (GO:0015824)3.65269023
44fear response (GO:0042596)3.62277655
45positive regulation of dendritic spine development (GO:0060999)3.57322118
46transmission of nerve impulse (GO:0019226)3.52512641
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.51686827
48positive regulation of neurotransmitter secretion (GO:0001956)3.49090536
49regulation of dendritic spine morphogenesis (GO:0061001)3.48561565
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47505852
51response to histamine (GO:0034776)3.47293262
52righting reflex (GO:0060013)3.43014368
53calcium ion-dependent exocytosis (GO:0017156)3.40825416
54cerebellar Purkinje cell differentiation (GO:0021702)3.35184802
55negative regulation of hormone biosynthetic process (GO:0032353)3.30244608
56negative regulation of hormone metabolic process (GO:0032351)3.30244608
57neuron recognition (GO:0008038)3.29964657
58sodium ion export (GO:0071436)3.29959992
59presynaptic membrane assembly (GO:0097105)3.28615692
60regulation of vesicle fusion (GO:0031338)3.27678406
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27636591
62regulation of calcium ion-dependent exocytosis (GO:0017158)3.26560205
63retinal cone cell development (GO:0046549)3.25050596
64regulation of acrosome reaction (GO:0060046)3.24913189
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.23919675
66regulation of neurotransmitter secretion (GO:0046928)3.22100946
67cellular potassium ion homeostasis (GO:0030007)3.21465844
68amino acid import (GO:0043090)3.18395568
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18385692
70multicellular organism reproduction (GO:0032504)3.17952722
71startle response (GO:0001964)3.17196271
72regulation of synaptic transmission (GO:0050804)3.16631564
73primary amino compound metabolic process (GO:1901160)3.14630033
74neurotransmitter transport (GO:0006836)3.14068330
75phosphorelay signal transduction system (GO:0000160)3.13749312
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12667417
77positive regulation of neurotransmitter transport (GO:0051590)3.09531356
78neuronal ion channel clustering (GO:0045161)3.09475339
79postsynaptic membrane organization (GO:0001941)3.09188762
80microtubule severing (GO:0051013)3.07526441
81neuromuscular synaptic transmission (GO:0007274)3.07505297
82cochlea development (GO:0090102)3.07172673
83membrane depolarization (GO:0051899)3.07040570
84serotonin metabolic process (GO:0042428)3.06472480
85layer formation in cerebral cortex (GO:0021819)3.05630543
86regulation of synapse maturation (GO:0090128)3.01616751
87potassium ion transmembrane transport (GO:0071805)3.01259006
88cellular potassium ion transport (GO:0071804)3.01259006
89regulation of dendritic spine development (GO:0060998)3.00883672
90neuromuscular process controlling posture (GO:0050884)3.00370100
91negative regulation of dendrite morphogenesis (GO:0050774)3.00219688
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00189099
93positive regulation of synaptic transmission (GO:0050806)2.99262875
94presynaptic membrane organization (GO:0097090)2.97929360
95synaptic transmission (GO:0007268)2.97373480
96regulation of glutamate secretion (GO:0014048)2.97311279
97regulation of inositol phosphate biosynthetic process (GO:0010919)2.97070099
98regulation of neurotransmitter transport (GO:0051588)2.97052648
99dendritic spine morphogenesis (GO:0060997)2.95418166
100positive regulation of dendritic spine morphogenesis (GO:0061003)2.94279405
101negative regulation of amino acid transport (GO:0051956)2.94157352
102cerebellar granule cell differentiation (GO:0021707)2.93463973
103innervation (GO:0060384)2.92087161
104C4-dicarboxylate transport (GO:0015740)2.91872957
105membrane depolarization during action potential (GO:0086010)2.91627158
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91620341
107regulation of neurotransmitter levels (GO:0001505)2.90840220
108gamma-aminobutyric acid transport (GO:0015812)2.90506590
109central nervous system myelination (GO:0022010)2.90186503
110axon ensheathment in central nervous system (GO:0032291)2.90186503
111regulation of synapse structural plasticity (GO:0051823)2.89743265
112neurotransmitter uptake (GO:0001504)2.88927550
113dendritic spine organization (GO:0097061)2.88672298
114male meiosis (GO:0007140)2.88370872
115chemosensory behavior (GO:0007635)2.88240697
116axonal fasciculation (GO:0007413)2.87500922
117learning (GO:0007612)2.86984138
118acidic amino acid transport (GO:0015800)2.86933831
119synaptic vesicle transport (GO:0048489)2.86037994
120establishment of synaptic vesicle localization (GO:0097480)2.86037994
121positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86011508
122long term synaptic depression (GO:0060292)2.84788475
123adult walking behavior (GO:0007628)2.84204421
124social behavior (GO:0035176)2.83904886
125intraspecies interaction between organisms (GO:0051703)2.83904886
126alanine transport (GO:0032328)2.79581832
127detection of calcium ion (GO:0005513)2.78506415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.43829173
2GBX2_23144817_ChIP-Seq_PC3_Human3.70823251
3REST_21632747_ChIP-Seq_MESCs_Mouse2.71167205
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61859638
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60825179
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57600026
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43388694
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.34230595
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28572673
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28572673
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23055269
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20771064
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.19612939
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18568613
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16743097
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.14678804
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13725802
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.13319347
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06923369
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01866556
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00205084
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97830665
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.95518718
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93056114
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92301042
26VDR_22108803_ChIP-Seq_LS180_Human1.90966911
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85281258
28* EED_16625203_ChIP-ChIP_MESCs_Mouse1.82784222
29* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82709116
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80580408
31DROSHA_22980978_ChIP-Seq_HELA_Human1.80187959
32TAF15_26573619_Chip-Seq_HEK293_Human1.76224991
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75816978
34SMAD4_21799915_ChIP-Seq_A2780_Human1.72099864
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67650237
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65388037
37FUS_26573619_Chip-Seq_HEK293_Human1.46902249
38MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46333846
39P300_19829295_ChIP-Seq_ESCs_Human1.41838074
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40596366
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.39378491
42* RNF2_27304074_Chip-Seq_NSC_Mouse1.38547375
43* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38096169
44AR_25329375_ChIP-Seq_VCAP_Human1.37944576
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37042389
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34912085
47AR_21572438_ChIP-Seq_LNCaP_Human1.32817691
48ZNF274_21170338_ChIP-Seq_K562_Hela1.30892269
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30251131
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.29421001
51STAT3_23295773_ChIP-Seq_U87_Human1.28830873
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.28589710
53* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28224788
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24803741
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.24536673
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24039192
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23722100
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23722100
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.21581806
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21062755
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20735801
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19360594
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18736769
64AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15266447
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15196916
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.13615054
67TCF4_23295773_ChIP-Seq_U87_Human1.13343343
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12183444
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.11680086
70* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10833272
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09830241
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09147747
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08263014
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07950287
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.07820667
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05857491
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05331982
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05261646
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04728135
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04078582
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03681281
82* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03418019
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03318717
84KDM2B_26808549_Chip-Seq_REH_Human1.02198105
85AR_19668381_ChIP-Seq_PC3_Human1.01988207
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00723611
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99605368
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99453038
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98621706
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98437297
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98320976
92CBP_20019798_ChIP-Seq_JUKART_Human0.98320976
93BCAT_22108803_ChIP-Seq_LS180_Human0.98148050
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97670982
95JUN_21703547_ChIP-Seq_K562_Human0.97297037
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97172456
97ELK4_26923725_Chip-Seq_MESODERM_Mouse0.97022965
98ERG_21242973_ChIP-ChIP_JURKAT_Human0.96549449
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96267310
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.96210523
101CTCF_27219007_Chip-Seq_Bcells_Human0.95452717
102IGF1R_20145208_ChIP-Seq_DFB_Human0.94775246
103* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94173920
104SMAD3_21741376_ChIP-Seq_ESCs_Human0.94063348
105KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93698437
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93476411
107* TP53_22573176_ChIP-Seq_HFKS_Human0.93338701
108RUNX2_22187159_ChIP-Seq_PCA_Human0.93070412
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.92895820
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92884419
111TCF4_22108803_ChIP-Seq_LS180_Human0.91996472
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.91948980
113ARNT_22903824_ChIP-Seq_MCF-7_Human0.90748028
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90548589
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.90177033
116ER_23166858_ChIP-Seq_MCF-7_Human0.89343764
117SOX2_19829295_ChIP-Seq_ESCs_Human0.88989495
118NANOG_19829295_ChIP-Seq_ESCs_Human0.88989495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.20117948
2MP0003880_abnormal_central_pattern5.50825212
3MP0003635_abnormal_synaptic_transmissio4.16771323
4MP0004270_analgesia3.64900020
5MP0002063_abnormal_learning/memory/cond3.44302813
6MP0009745_abnormal_behavioral_response3.42696757
7MP0002064_seizures3.03921034
8MP0002572_abnormal_emotion/affect_behav2.93064736
9MP0001968_abnormal_touch/_nociception2.90833336
10MP0009046_muscle_twitch2.84034392
11MP0002736_abnormal_nociception_after2.65926695
12MP0001501_abnormal_sleep_pattern2.55908349
13MP0002272_abnormal_nervous_system2.45772007
14MP0003787_abnormal_imprinting2.38270062
15MP0005410_abnormal_fertilization2.34569429
16MP0008877_abnormal_DNA_methylation2.32640976
17MP0001486_abnormal_startle_reflex2.28836449
18MP0002734_abnormal_mechanical_nocicepti2.27486140
19MP0001440_abnormal_grooming_behavior2.08975397
20MP0002735_abnormal_chemical_nociception2.00964085
21MP0005646_abnormal_pituitary_gland1.94933076
22MP0005423_abnormal_somatic_nervous1.92590310
23MP0003879_abnormal_hair_cell1.89737311
24MP0001905_abnormal_dopamine_level1.88310365
25MP0002067_abnormal_sensory_capabilities1.78980569
26MP0002653_abnormal_ependyma_morphology1.71354406
27MP0002822_catalepsy1.66189712
28MP0002733_abnormal_thermal_nociception1.64409987
29MP0001970_abnormal_pain_threshold1.60748304
30MP0003646_muscle_fatigue1.58611360
31MP0005386_behavior/neurological_phenoty1.56088338
32MP0004924_abnormal_behavior1.56088338
33MP0002184_abnormal_innervation1.54430200
34MP0000778_abnormal_nervous_system1.53822926
35MP0001529_abnormal_vocalization1.51590543
36MP0004811_abnormal_neuron_physiology1.51578819
37MP0002557_abnormal_social/conspecific_i1.49481198
38MP0008569_lethality_at_weaning1.44485361
39MP0002102_abnormal_ear_morphology1.39037828
40MP0004858_abnormal_nervous_system1.38780611
41MP0006276_abnormal_autonomic_nervous1.38469274
42MP0003698_abnormal_male_reproductive1.32660971
43MP0001984_abnormal_olfaction1.32052220
44MP0000955_abnormal_spinal_cord1.31685766
45MP0003123_paternal_imprinting1.29564072
46MP0002066_abnormal_motor_capabilities/c1.27684974
47MP0001929_abnormal_gametogenesis1.27145987
48MP0001502_abnormal_circadian_rhythm1.25503277
49MP0002638_abnormal_pupillary_reflex1.23465136
50* MP0002882_abnormal_neuron_morphology1.22825081
51MP0001986_abnormal_taste_sensitivity1.19981762
52MP0004043_abnormal_pH_regulation1.18182021
53MP0005645_abnormal_hypothalamus_physiol1.14981704
54MP0010386_abnormal_urinary_bladder1.13693861
55MP0004147_increased_porphyrin_level1.13517420
56MP0006292_abnormal_olfactory_placode1.12918814
57MP0003137_abnormal_impulse_conducting1.08701130
58MP0002837_dystrophic_cardiac_calcinosis1.08535867
59MP0004145_abnormal_muscle_electrophysio1.08418852
60* MP0003329_amyloid_beta_deposits1.04703587
61MP0001177_atelectasis1.03141654
62* MP0002152_abnormal_brain_morphology1.03129272
63MP0002161_abnormal_fertility/fecundity1.02815692
64MP0003633_abnormal_nervous_system1.00661748
65MP0009780_abnormal_chondrocyte_physiolo0.99173378
66MP0003718_maternal_effect0.97806621
67MP0010234_abnormal_vibrissa_follicle0.97652560
68MP0005253_abnormal_eye_physiology0.97076511
69MP0000751_myopathy0.96245208
70MP0001963_abnormal_hearing_physiology0.93788674
71* MP0003631_nervous_system_phenotype0.93242298
72MP0002876_abnormal_thyroid_physiology0.93201963
73MP0003075_altered_response_to0.90308628
74MP0002909_abnormal_adrenal_gland0.88805114
75MP0003121_genomic_imprinting0.88597766
76MP0004510_myositis0.88344596
77MP0004142_abnormal_muscle_tone0.88171623
78MP0008872_abnormal_physiological_respon0.86344866
79MP0005167_abnormal_blood-brain_barrier0.82865011
80MP0001485_abnormal_pinna_reflex0.82635647
81MP0004885_abnormal_endolymph0.81616706
82MP0000569_abnormal_digit_pigmentation0.81077070
83MP0008874_decreased_physiological_sensi0.80561142
84MP0002069_abnormal_eating/drinking_beha0.78269720
85MP0002160_abnormal_reproductive_system0.77692430
86MP0004484_altered_response_of0.76783083
87MP0001188_hyperpigmentation0.76704489
88MP0002229_neurodegeneration0.76334755
89MP0000920_abnormal_myelination0.76242271
90MP0001765_abnormal_ion_homeostasis0.75838864
91MP0002090_abnormal_vision0.75664321
92MP0000653_abnormal_sex_gland0.74806077
93MP0002752_abnormal_somatic_nervous0.71914734
94MP0003699_abnormal_female_reproductive0.71608082
95MP0003195_calcinosis0.71395640
96MP0004085_abnormal_heartbeat0.71393842
97MP0003861_abnormal_nervous_system0.71351371
98MP0004233_abnormal_muscle_weight0.71128980
99MP0002210_abnormal_sex_determination0.70883063
100MP0005551_abnormal_eye_electrophysiolog0.70402766
101MP0003122_maternal_imprinting0.69367331
102MP0000631_abnormal_neuroendocrine_gland0.65591089
103MP0004215_abnormal_myocardial_fiber0.65413653
104MP0005499_abnormal_olfactory_system0.63399621
105MP0005394_taste/olfaction_phenotype0.63399621
106MP0003690_abnormal_glial_cell0.62460636
107* MP0003632_abnormal_nervous_system0.62300257
108MP0003878_abnormal_ear_physiology0.59433605
109MP0005377_hearing/vestibular/ear_phenot0.59433605
110MP0000026_abnormal_inner_ear0.59051437
111MP0005535_abnormal_body_temperature0.58551096
112MP0004133_heterotaxia0.57302840
113MP0003283_abnormal_digestive_organ0.57122889
114MP0002163_abnormal_gland_morphology0.55632716
115MP0006072_abnormal_retinal_apoptosis0.55292446
116MP0003136_yellow_coat_color0.54817924
117MP0005379_endocrine/exocrine_gland_phen0.54525371
118MP0001145_abnormal_male_reproductive0.54322909
119MP0004742_abnormal_vestibular_system0.54083401
120MP0003938_abnormal_ear_development0.53964698
121MP0002234_abnormal_pharynx_morphology0.53433917
122MP0005195_abnormal_posterior_eye0.49970055
123MP0001346_abnormal_lacrimal_gland0.49763103

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.01569347
2Myokymia (HP:0002411)5.82448942
3Focal seizures (HP:0007359)5.50465647
4Epileptic encephalopathy (HP:0200134)5.48143570
5Atonic seizures (HP:0010819)5.45290735
6Visual hallucinations (HP:0002367)4.62606743
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.47445443
8Febrile seizures (HP:0002373)4.45386621
9Absence seizures (HP:0002121)4.09979368
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.07944849
11Absent/shortened dynein arms (HP:0200106)4.07944849
12Dialeptic seizures (HP:0011146)3.88209915
13Generalized tonic-clonic seizures (HP:0002069)3.81808608
14Progressive cerebellar ataxia (HP:0002073)3.72198242
15Hyperventilation (HP:0002883)3.57919069
16Abnormality of the lower motor neuron (HP:0002366)3.55709981
17Amblyopia (HP:0000646)3.54897247
18Impaired vibration sensation in the lower limbs (HP:0002166)3.39953408
19Infertility (HP:0000789)3.33648381
20Abnormal respiratory motile cilium physiology (HP:0012261)3.33399789
21Gaze-evoked nystagmus (HP:0000640)3.32785023
22Male infertility (HP:0003251)3.14655936
23Dysmetria (HP:0001310)2.92541287
24Broad-based gait (HP:0002136)2.92407836
25Diplopia (HP:0000651)2.86932712
26Abnormality of binocular vision (HP:0011514)2.86932712
27Delusions (HP:0000746)2.81890027
28Limb dystonia (HP:0002451)2.79012143
29Urinary bladder sphincter dysfunction (HP:0002839)2.76416047
30Dysdiadochokinesis (HP:0002075)2.73032995
31Congenital stationary night blindness (HP:0007642)2.72249547
32Fetal akinesia sequence (HP:0001989)2.71896242
33Abnormal eating behavior (HP:0100738)2.64029228
34Epileptiform EEG discharges (HP:0011182)2.63540917
35Cerebral inclusion bodies (HP:0100314)2.63210837
36Abnormal ciliary motility (HP:0012262)2.62615900
37Rhinitis (HP:0012384)2.62523382
38Abnormal respiratory epithelium morphology (HP:0012253)2.59062529
39Abnormal respiratory motile cilium morphology (HP:0005938)2.59062529
40Abnormal gallbladder physiology (HP:0012438)2.56153007
41Cholecystitis (HP:0001082)2.56153007
42Cerebral hypomyelination (HP:0006808)2.53920031
43Absent speech (HP:0001344)2.53288436
44Excessive salivation (HP:0003781)2.50744180
45Drooling (HP:0002307)2.50744180
46Action tremor (HP:0002345)2.50021020
47Impaired vibratory sensation (HP:0002495)2.41596233
48Chronic bronchitis (HP:0004469)2.41190228
49Impaired smooth pursuit (HP:0007772)2.40738624
50Poor eye contact (HP:0000817)2.40453763
51Inability to walk (HP:0002540)2.35571251
52Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.35478933
53Dysmetric saccades (HP:0000641)2.35309178
54Genetic anticipation (HP:0003743)2.33688492
55EEG with generalized epileptiform discharges (HP:0011198)2.30486558
56Supranuclear gaze palsy (HP:0000605)2.28194461
57Decreased central vision (HP:0007663)2.27788094
58Hemiparesis (HP:0001269)2.27063492
59Postural instability (HP:0002172)2.26561321
60Neurofibrillary tangles (HP:0002185)2.25094367
61Molar tooth sign on MRI (HP:0002419)2.24468772
62Abnormality of midbrain morphology (HP:0002418)2.24468772
63Generalized myoclonic seizures (HP:0002123)2.24236729
64Abnormality of the labia minora (HP:0012880)2.22001767
65Gait imbalance (HP:0002141)2.21535820
66Pancreatic fibrosis (HP:0100732)2.20498721
67Papilledema (HP:0001085)2.16281257
68Medial flaring of the eyebrow (HP:0010747)2.16246392
69Progressive inability to walk (HP:0002505)2.13573883
70Truncal ataxia (HP:0002078)2.09933795
71Abnormality of ocular smooth pursuit (HP:0000617)2.09682707
72Spastic gait (HP:0002064)2.08909281
73Depression (HP:0000716)2.08277604
74Hypsarrhythmia (HP:0002521)2.07998986
75Status epilepticus (HP:0002133)2.06167713
76Impaired social interactions (HP:0000735)2.04880482
77Abnormal social behavior (HP:0012433)2.04880482
78Congenital primary aphakia (HP:0007707)2.04086640
79CNS hypomyelination (HP:0003429)2.04012188
80Thickened helices (HP:0000391)2.03316292
81Polydipsia (HP:0001959)2.03240554
82Abnormal drinking behavior (HP:0030082)2.03240554
83Tetraplegia (HP:0002445)2.03207494
84Pancreatic cysts (HP:0001737)2.03203650
85Ankle clonus (HP:0011448)2.03098364
86Intention tremor (HP:0002080)2.02838447
87Protruding tongue (HP:0010808)2.01383967
88Insidious onset (HP:0003587)2.00608953
89Termporal pattern (HP:0011008)2.00608953
90Polyphagia (HP:0002591)1.98355073
91Torticollis (HP:0000473)1.97144419
92Incomplete penetrance (HP:0003829)1.97004893
93Hypomagnesemia (HP:0002917)1.95809739
94Mutism (HP:0002300)1.94306438
95Spastic tetraparesis (HP:0001285)1.94129787
96Stereotypic behavior (HP:0000733)1.93223327
97Attenuation of retinal blood vessels (HP:0007843)1.92501187
98Anxiety (HP:0000739)1.92331250
99Akinesia (HP:0002304)1.92238280
100Retinal dysplasia (HP:0007973)1.91268260
101Bundle branch block (HP:0011710)1.91196874
102Unsteady gait (HP:0002317)1.89456756
103Urinary urgency (HP:0000012)1.89438742
104Craniofacial dystonia (HP:0012179)1.88925322
105Nephrogenic diabetes insipidus (HP:0009806)1.87527797
106Nephronophthisis (HP:0000090)1.87072285
107Syncope (HP:0001279)1.85429682
108Abnormal EKG (HP:0003115)1.85091460
109Focal dystonia (HP:0004373)1.84509298
110Hemiplegia (HP:0002301)1.82356104
111Bradykinesia (HP:0002067)1.81972312
112Annular pancreas (HP:0001734)1.81262204
113Deep palmar crease (HP:0006191)1.81207426
114True hermaphroditism (HP:0010459)1.80595775
115Prolonged QT interval (HP:0001657)1.79664507
116Ventricular fibrillation (HP:0001663)1.76677948
117Nonprogressive disorder (HP:0003680)1.74507254
118Type II lissencephaly (HP:0007260)1.72248025
119Amyotrophic lateral sclerosis (HP:0007354)1.72232528
120Poor coordination (HP:0002370)1.71453710
121Oligodactyly (hands) (HP:0001180)1.69828888
122Dyskinesia (HP:0100660)1.68720464
123Chronic hepatic failure (HP:0100626)1.68103487
124Heart block (HP:0012722)1.66969740
125Specific learning disability (HP:0001328)1.66858506
126Abnormality of the corticospinal tract (HP:0002492)1.66765085
127Acute necrotizing encephalopathy (HP:0006965)1.66693786
128Increased circulating renin level (HP:0000848)1.65609837
129Clonus (HP:0002169)1.65554988
130Genital tract atresia (HP:0001827)1.63263755
131Lower limb muscle weakness (HP:0007340)1.63172775
132Choreoathetosis (HP:0001266)1.62496403
133Anosmia (HP:0000458)1.61375628
134Abnormality of magnesium homeostasis (HP:0004921)1.60778895
135Gait ataxia (HP:0002066)1.60083733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.59153043
2MAP3K94.55646429
3NTRK34.16629897
4KSR23.15415523
5ARAF2.85745310
6MAP3K132.67313143
7MAP3K42.63454062
8PRKD32.55419236
9DAPK22.45411370
10PAK62.31565618
11FRK2.22793883
12MAP2K72.21372147
13KSR12.16174173
14PLK22.13777774
15CASK2.09571967
16BRAF2.03375763
17RAF11.86157341
18DAPK11.80300881
19RIPK41.75761165
20MUSK1.73414743
21MAP3K121.70434468
22MINK11.69437285
23LATS21.65446307
24PTK2B1.64042666
25NTRK21.58163081
26MAP2K41.56381644
27GRK51.55265789
28PRPF4B1.53785272
29MAP3K61.53479946
30CDK191.47099289
31STK381.42350451
32MAPK131.41183868
33MOS1.32579541
34BMPR21.30778009
35TAOK11.23788973
36PHKG11.23221795
37PHKG21.23221795
38CCNB11.18064407
39GRK11.16784982
40PDK31.14598659
41PDK41.14598659
42TYRO31.12980469
43CDK51.11672531
44INSRR1.10273656
45MARK11.08922647
46CAMK2A1.04323544
47PNCK1.04006271
48WNK41.02549770
49CAMKK21.00242449
50BMPR1B0.98896192
51PRKCG0.96924877
52NTRK10.94324935
53CAMK40.90462416
54TTK0.88411495
55MARK20.87324909
56CAMKK10.85969023
57ADRBK20.84114363
58CDK180.83583861
59WNK30.83104334
60ZAK0.81925189
61TNIK0.81102825
62BRSK10.80426736
63CDK150.80180785
64PKN10.79952807
65ERBB40.79501936
66PRKCE0.79474591
67STK390.78093372
68ACVR1B0.76612394
69FES0.76477426
70NUAK10.75627727
71OXSR10.73349443
72MAP3K20.72794357
73FGR0.72122903
74MAP4K20.71923748
75PINK10.71402496
76SIK20.70076481
77CDK140.68982946
78CDK11A0.68900329
79TIE10.67006844
80CAMK10.66723860
81CSNK1G30.66062489
82CAMK2B0.64961574
83NEK60.63182158
84MAP3K10.62981355
85MAP2K60.61535474
86NME10.61376365
87CSNK1G10.57634503
88TAOK30.57520296
89FGFR20.57305187
90CSNK1A1L0.57302193
91CDK80.57292418
92PDK10.57094640
93DYRK20.56298205
94STK110.55312913
95SGK4940.54823786
96SGK2230.54823786
97ALK0.54508473
98PDK20.54066532
99LIMK10.52487274
100MAP2K10.52011680
101DYRK1A0.50236622
102MAPKAPK50.50060256
103PDPK10.49953857
104PLK40.47306537
105TRIM280.46695810
106PRKCA0.46620176
107STK160.46350418
108AKT30.46043773
109CAMK2D0.45748721
110SGK10.45153730
111EEF2K0.43993285
112PAK30.43532395
113SGK20.41629971
114MKNK20.41481015
115CSNK1A10.40310536
116UHMK10.40238962
117RET0.40152691
118PRKACA0.39720726
119MAP3K110.38790988
120CSNK1G20.38629530
121CSNK1E0.37841521
122DMPK0.37045477
123SIK30.34028548
124CHEK20.32964919
125ICK0.32377179
126PRKD20.32331036
127RPS6KA30.31338260
128GRK60.31244729
129PLK30.28976616
130FER0.28744161
131MAPK120.28388747
132STK38L0.27594571
133MAPKAPK30.25999433
134DAPK30.25438048
135PRKCZ0.25101770
136MAPK100.24075765
137CAMK2G0.24023373
138PRKCH0.22902893
139CDK30.21731951

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.23331774
2Synaptic vesicle cycle_Homo sapiens_hsa047213.61719670
3Long-term potentiation_Homo sapiens_hsa047203.08653165
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82537767
5Amphetamine addiction_Homo sapiens_hsa050312.78933801
6Circadian entrainment_Homo sapiens_hsa047132.75238142
7Glutamatergic synapse_Homo sapiens_hsa047242.73122543
8Olfactory transduction_Homo sapiens_hsa047402.55186362
9GABAergic synapse_Homo sapiens_hsa047272.34430403
10Morphine addiction_Homo sapiens_hsa050322.27111942
11Collecting duct acid secretion_Homo sapiens_hsa049662.26714186
12Salivary secretion_Homo sapiens_hsa049702.21943128
13Dopaminergic synapse_Homo sapiens_hsa047282.01680500
14Insulin secretion_Homo sapiens_hsa049111.99463761
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93457559
16Oxytocin signaling pathway_Homo sapiens_hsa049211.86111608
17Long-term depression_Homo sapiens_hsa047301.84691383
18Taste transduction_Homo sapiens_hsa047421.80071865
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79478500
20GnRH signaling pathway_Homo sapiens_hsa049121.78027369
21Gastric acid secretion_Homo sapiens_hsa049711.74943601
22Serotonergic synapse_Homo sapiens_hsa047261.74429323
23Calcium signaling pathway_Homo sapiens_hsa040201.72917562
24Cholinergic synapse_Homo sapiens_hsa047251.63969353
25Renin secretion_Homo sapiens_hsa049241.60781066
26Oocyte meiosis_Homo sapiens_hsa041141.56027184
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50235321
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39442281
29Cocaine addiction_Homo sapiens_hsa050301.37224488
30cAMP signaling pathway_Homo sapiens_hsa040241.34428582
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30336890
32Estrogen signaling pathway_Homo sapiens_hsa049151.22370178
33Dorso-ventral axis formation_Homo sapiens_hsa043201.19632223
34Gap junction_Homo sapiens_hsa045401.18956960
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18338905
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16254864
37Vibrio cholerae infection_Homo sapiens_hsa051101.13504848
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13229592
39Circadian rhythm_Homo sapiens_hsa047101.12232899
40Butanoate metabolism_Homo sapiens_hsa006501.06480121
41Glioma_Homo sapiens_hsa052141.03935548
42Cardiac muscle contraction_Homo sapiens_hsa042601.03243531
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02917849
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.02391109
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98095125
46Ovarian steroidogenesis_Homo sapiens_hsa049130.96103453
47ErbB signaling pathway_Homo sapiens_hsa040120.95726337
48Melanogenesis_Homo sapiens_hsa049160.93323651
49Choline metabolism in cancer_Homo sapiens_hsa052310.93184727
50VEGF signaling pathway_Homo sapiens_hsa043700.89477080
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89068583
52Axon guidance_Homo sapiens_hsa043600.87134716
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85510569
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.84530679
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84024510
56Parkinsons disease_Homo sapiens_hsa050120.83856417
57Glucagon signaling pathway_Homo sapiens_hsa049220.83729914
58Type II diabetes mellitus_Homo sapiens_hsa049300.82252531
59Vitamin B6 metabolism_Homo sapiens_hsa007500.75915980
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75882661
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74523708
62MAPK signaling pathway_Homo sapiens_hsa040100.73583242
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70907839
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70003101
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68217683
66Pancreatic secretion_Homo sapiens_hsa049720.67780369
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67287098
68Linoleic acid metabolism_Homo sapiens_hsa005910.64824263
69Inositol phosphate metabolism_Homo sapiens_hsa005620.64794468
70Ras signaling pathway_Homo sapiens_hsa040140.64195446
71Arginine and proline metabolism_Homo sapiens_hsa003300.61957635
72Propanoate metabolism_Homo sapiens_hsa006400.61695450
73Thyroid hormone synthesis_Homo sapiens_hsa049180.60667473
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60129167
75beta-Alanine metabolism_Homo sapiens_hsa004100.59525133
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54781473
77Nitrogen metabolism_Homo sapiens_hsa009100.54418626
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53099126
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.53053151
80Dilated cardiomyopathy_Homo sapiens_hsa054140.52235326
81Alzheimers disease_Homo sapiens_hsa050100.50840485
82Oxidative phosphorylation_Homo sapiens_hsa001900.50796796
83Sulfur relay system_Homo sapiens_hsa041220.49033755
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48991538
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48780637
86Regulation of autophagy_Homo sapiens_hsa041400.48031749
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47974197
88Wnt signaling pathway_Homo sapiens_hsa043100.47923523
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46906018
90Phototransduction_Homo sapiens_hsa047440.46458131
91Mineral absorption_Homo sapiens_hsa049780.45472928
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43679084
93Rap1 signaling pathway_Homo sapiens_hsa040150.43319768
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42943389
95Huntingtons disease_Homo sapiens_hsa050160.41128449
96Rheumatoid arthritis_Homo sapiens_hsa053230.39626988
97Renal cell carcinoma_Homo sapiens_hsa052110.38728102
98mTOR signaling pathway_Homo sapiens_hsa041500.38143463
99Ether lipid metabolism_Homo sapiens_hsa005650.37462076
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37046178
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36322210
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.34792019
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.34548704
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.34250664
105Folate biosynthesis_Homo sapiens_hsa007900.32847398
106Prion diseases_Homo sapiens_hsa050200.32392771
107Tryptophan metabolism_Homo sapiens_hsa003800.32199653
108Selenocompound metabolism_Homo sapiens_hsa004500.31420336
109Homologous recombination_Homo sapiens_hsa034400.30943380
110African trypanosomiasis_Homo sapiens_hsa051430.29680757
111ABC transporters_Homo sapiens_hsa020100.28549388
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28545780
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27651690
114Colorectal cancer_Homo sapiens_hsa052100.27582218
115Purine metabolism_Homo sapiens_hsa002300.27377980
116Endocytosis_Homo sapiens_hsa041440.26959574
117Fatty acid biosynthesis_Homo sapiens_hsa000610.26867737
118Hippo signaling pathway_Homo sapiens_hsa043900.26560783
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26234224
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25572241
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24647793
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24035899
123Non-small cell lung cancer_Homo sapiens_hsa052230.22374774
124Alcoholism_Homo sapiens_hsa050340.21007250
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20673056
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20243014
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19225285
128Bile secretion_Homo sapiens_hsa049760.19097220

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