SLC30A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)4.21983288
2protein localization to endosome (GO:0036010)4.07524183
3adaptation of signaling pathway (GO:0023058)4.07033044
4cell adhesion mediated by integrin (GO:0033627)3.87276511
5chondrocyte proliferation (GO:0035988)3.81990742
6plasma membrane repair (GO:0001778)3.78198990
7ketone body metabolic process (GO:1902224)3.77493686
8collagen fibril organization (GO:0030199)3.44618289
9indolalkylamine metabolic process (GO:0006586)3.38882417
10regulation of glucokinase activity (GO:0033131)3.38323588
11regulation of hexokinase activity (GO:1903299)3.38323588
12behavioral response to nicotine (GO:0035095)3.35937395
13iron ion import (GO:0097286)3.35864916
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.33755311
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.33744482
16regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28570753
17auditory receptor cell differentiation (GO:0042491)3.27310132
18insulin-like growth factor receptor signaling pathway (GO:0048009)3.16948204
19polyol catabolic process (GO:0046174)3.14732035
20detection of light stimulus involved in sensory perception (GO:0050962)3.13596362
21detection of light stimulus involved in visual perception (GO:0050908)3.13596362
22reflex (GO:0060004)3.08518015
23protein K11-linked deubiquitination (GO:0035871)3.06916438
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.06048383
25locomotory exploration behavior (GO:0035641)3.04655274
26establishment of nucleus localization (GO:0040023)3.03576239
27platelet dense granule organization (GO:0060155)3.02580415
28kynurenine metabolic process (GO:0070189)3.01295328
29tryptophan catabolic process (GO:0006569)3.00563407
30indole-containing compound catabolic process (GO:0042436)3.00563407
31indolalkylamine catabolic process (GO:0046218)3.00563407
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00364962
33purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00364962
34response to pheromone (GO:0019236)2.99079861
35negative regulation of fatty acid transport (GO:2000192)2.97594746
36axoneme assembly (GO:0035082)2.96232442
37preassembly of GPI anchor in ER membrane (GO:0016254)2.96180796
38synaptic vesicle docking involved in exocytosis (GO:0016081)2.93888232
39negative regulation of systemic arterial blood pressure (GO:0003085)2.91615319
40skin morphogenesis (GO:0043589)2.89069418
41water-soluble vitamin biosynthetic process (GO:0042364)2.88950795
42retinal cone cell development (GO:0046549)2.88454240
43magnesium ion transport (GO:0015693)2.88164881
44L-fucose catabolic process (GO:0042355)2.84142044
45fucose catabolic process (GO:0019317)2.84142044
46L-fucose metabolic process (GO:0042354)2.84142044
47protein localization to cell surface (GO:0034394)2.82886319
48proline transport (GO:0015824)2.81639780
49kidney morphogenesis (GO:0060993)2.81315176
50regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.80664864
51multicellular organism reproduction (GO:0032504)2.80221053
52inositol phosphate catabolic process (GO:0071545)2.75701879
53chondrocyte development (GO:0002063)2.74275899
54tryptophan metabolic process (GO:0006568)2.73189429
55piRNA metabolic process (GO:0034587)2.73020595
56neuron projection extension involved in neuron projection guidance (GO:1902284)2.72838426
57axon extension involved in axon guidance (GO:0048846)2.72838426
58cellular response to vitamin D (GO:0071305)2.72339476
59protein heterotrimerization (GO:0070208)2.71289421
60hippo signaling (GO:0035329)2.70963777
61DNA deamination (GO:0045006)2.70451635
62hemidesmosome assembly (GO:0031581)2.69293773
63photoreceptor cell maintenance (GO:0045494)2.68774713
64branched-chain amino acid catabolic process (GO:0009083)2.68399489
65protein localization to cilium (GO:0061512)2.65421480
66dendrite morphogenesis (GO:0048813)2.63957823
67layer formation in cerebral cortex (GO:0021819)2.62702625
68startle response (GO:0001964)2.62516952
69clathrin coat assembly (GO:0048268)2.61677582
70apoptotic cell clearance (GO:0043277)2.61539832
71righting reflex (GO:0060013)2.61530920
72endodermal cell differentiation (GO:0035987)2.60407539
73glutamate secretion (GO:0014047)2.60210893
74regulation of clathrin-mediated endocytosis (GO:2000369)2.59389038
75nonmotile primary cilium assembly (GO:0035058)2.59046030
76adenosine metabolic process (GO:0046085)2.57882864
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57776625
78stress fiber assembly (GO:0043149)2.57131193
79positive regulation of glycolytic process (GO:0045821)2.56686476
80import into cell (GO:0098657)2.56653196
81primary amino compound metabolic process (GO:1901160)2.56176659
82serotonin metabolic process (GO:0042428)2.54502852
83regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53839822
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53702633
85regulation of action potential (GO:0098900)2.52210274
86regulation of synaptic vesicle exocytosis (GO:2000300)2.52168396
87sulfation (GO:0051923)2.52037680
88indole-containing compound metabolic process (GO:0042430)2.51233480
89growth hormone receptor signaling pathway (GO:0060396)2.49215231
90DNA methylation involved in gamete generation (GO:0043046)2.48713715
91protein localization to synapse (GO:0035418)2.48336848
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48249686
93neuronal action potential (GO:0019228)2.47461741
94sequestering of extracellular ligand from receptor (GO:0035581)2.46813036
95synaptic vesicle maturation (GO:0016188)2.44898453
96positive regulation of vesicle fusion (GO:0031340)2.44417575
97COPI coating of Golgi vesicle (GO:0048205)2.44309877
98Golgi transport vesicle coating (GO:0048200)2.44309877
99gamma-aminobutyric acid transport (GO:0015812)2.43247967
100alkaloid metabolic process (GO:0009820)2.42540217
101protein polyglutamylation (GO:0018095)2.42535419
102cellular response to vitamin (GO:0071295)2.41716945
103epithelial cilium movement (GO:0003351)2.41624946
104nerve growth factor signaling pathway (GO:0038180)2.41423361
105negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40770722
106regulation of type B pancreatic cell apoptotic process (GO:2000674)2.40427538
107signal peptide processing (GO:0006465)2.39267736
108regulation of dendritic spine morphogenesis (GO:0061001)2.39111194
109regulation of transforming growth factor beta1 production (GO:0032908)2.39006427
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.38520350
111positive regulation of meiosis (GO:0045836)2.37955074
112insulin secretion (GO:0030073)2.37543031
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36370821
114platelet-derived growth factor receptor signaling pathway (GO:0048008)2.36167859
115biotin metabolic process (GO:0006768)2.35914264
116somite rostral/caudal axis specification (GO:0032525)2.35234103
117dendritic spine morphogenesis (GO:0060997)2.34838923
118oxidative demethylation (GO:0070989)2.34548374
119regulation of protein glycosylation (GO:0060049)2.34451779
120positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.33957633
121positive regulation of nitric-oxide synthase activity (GO:0051000)2.33501983
122nitric oxide mediated signal transduction (GO:0007263)2.33313760
123GPI anchor metabolic process (GO:0006505)2.33085631
124negative regulation of mast cell activation (GO:0033004)2.33011581
125dopamine transport (GO:0015872)2.32997922
126artery development (GO:0060840)2.32374462
127intestinal epithelial cell development (GO:0060576)2.31548767
128regulation of calcium ion-dependent exocytosis (GO:0017158)2.30960461
129photoreceptor cell development (GO:0042461)2.30534510
130prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.30364383
131axon extension (GO:0048675)2.30097142
132negative regulation of sodium ion transport (GO:0010766)2.29381496
133embryonic viscerocranium morphogenesis (GO:0048703)2.29007887
134peptidyl-proline hydroxylation (GO:0019511)2.28768121
135neuron cell-cell adhesion (GO:0007158)2.28747855
136vesicle transport along microtubule (GO:0047496)2.28634685
137positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.28472427
138rhodopsin mediated signaling pathway (GO:0016056)2.26822710
139positive regulation of fibroblast migration (GO:0010763)2.26714950
140C-terminal protein lipidation (GO:0006501)2.26665280
141positive regulation of fatty acid transport (GO:2000193)2.26609723
142positive regulation of macrophage cytokine production (GO:0060907)2.25770515
143cellular response to interferon-alpha (GO:0035457)2.25069951
144protein import into peroxisome matrix (GO:0016558)2.24837833
145regulation of rhodopsin mediated signaling pathway (GO:0022400)2.24730295
146positive regulation of protein localization to plasma membrane (GO:1903078)2.23758730
147drug catabolic process (GO:0042737)2.22783841
148behavioral response to ethanol (GO:0048149)2.22309251
149actin cytoskeleton reorganization (GO:0031532)2.21773089
150semaphorin-plexin signaling pathway (GO:0071526)2.21547752
151cornea development in camera-type eye (GO:0061303)2.20656208
152multicellular organismal macromolecule metabolic process (GO:0044259)2.20636104
153substrate-dependent cell migration (GO:0006929)2.20600060
154regulation of acrosome reaction (GO:0060046)2.20513244
155positive regulation of meiotic cell cycle (GO:0051446)2.20433526
156cell migration involved in sprouting angiogenesis (GO:0002042)2.20316978
157protein hydroxylation (GO:0018126)2.20237568
158Golgi to endosome transport (GO:0006895)2.19857377
159C-terminal protein amino acid modification (GO:0018410)2.19704552
160activation of protein kinase A activity (GO:0034199)2.19686459
161collagen metabolic process (GO:0032963)2.19075643
162collagen catabolic process (GO:0030574)2.18823903
163syncytium formation (GO:0006949)2.18556987
164cellular potassium ion homeostasis (GO:0030007)2.17017626
165positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.16543099
166multicellular organismal catabolic process (GO:0044243)2.14167554
167vocalization behavior (GO:0071625)2.13918385
168positive regulation of p38MAPK cascade (GO:1900745)2.13760672
169cellular response to growth hormone stimulus (GO:0071378)2.13242278
170multicellular organismal metabolic process (GO:0044236)2.13195295
171protein targeting to plasma membrane (GO:0072661)2.12932742
172membrane assembly (GO:0071709)2.12572773
173regulation of tight junction assembly (GO:2000810)2.12092284
174positive regulation of cardiac muscle hypertrophy (GO:0010613)2.11975487
175positive regulation of muscle hypertrophy (GO:0014742)2.11975487
176myoblast fusion (GO:0007520)2.11855726
177endothelial cell morphogenesis (GO:0001886)2.11805568
178positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.10810160
179neuron projection extension (GO:1990138)2.09301915
180regulation of dendritic spine development (GO:0060998)2.08429553
181vesicle coating (GO:0006901)2.08114202
182axonal fasciculation (GO:0007413)2.07517898
183syncytium formation by plasma membrane fusion (GO:0000768)2.06996754
184neuromuscular junction development (GO:0007528)2.06895646
185cortical actin cytoskeleton organization (GO:0030866)2.06749533
186retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.06169092
187extracellular matrix disassembly (GO:0022617)2.05205992
188retina vasculature morphogenesis in camera-type eye (GO:0061299)2.04917039
189regulation of integrin-mediated signaling pathway (GO:2001044)2.04621144
190actin filament bundle organization (GO:0061572)2.04019092
191actin filament bundle assembly (GO:0051017)2.04019092
192establishment of protein localization to Golgi (GO:0072600)2.02548912
193positive regulation of cardiac muscle cell differentiation (GO:2000727)2.01594916
194endocardial cushion development (GO:0003197)2.01472612
195protein targeting to Golgi (GO:0000042)2.01292443
196response to nerve growth factor (GO:1990089)2.00992859
197cellular response to nerve growth factor stimulus (GO:1990090)2.00992859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.15868371
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.06022583
3IGF1R_20145208_ChIP-Seq_DFB_Human2.94991313
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86574273
5VDR_22108803_ChIP-Seq_LS180_Human2.85584487
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.39933718
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.25875182
8* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21413651
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15057124
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.10176220
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09542500
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04983296
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.91549770
14FUS_26573619_Chip-Seq_HEK293_Human1.88609355
15TAF15_26573619_Chip-Seq_HEK293_Human1.86549822
16GBX2_23144817_ChIP-Seq_PC3_Human1.85723958
17* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.83492774
18* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.83492774
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.83287134
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82592727
21TP53_16413492_ChIP-PET_HCT116_Human1.81237729
22ER_23166858_ChIP-Seq_MCF-7_Human1.80732348
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80180617
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79889854
25EWS_26573619_Chip-Seq_HEK293_Human1.79819678
26* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71566446
27CJUN_26792858_Chip-Seq_BT549_Human1.71210294
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.67328170
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66472599
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65792957
31TP53_18474530_ChIP-ChIP_U2OS_Human1.62995868
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60867065
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59865434
34* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.56807938
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52371046
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51633511
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50444187
38CLOCK_20551151_ChIP-Seq_293T_Human1.50375569
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50089563
40CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49480995
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49358830
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49358830
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.49241238
44* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48549835
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.47525670
46CBP_20019798_ChIP-Seq_JUKART_Human1.46955442
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46955442
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46511547
49* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46171597
50* TCF4_23295773_ChIP-Seq_U87_Human1.46137229
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43281450
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43250881
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42748139
54AR_21572438_ChIP-Seq_LNCaP_Human1.41744250
55RXR_22108803_ChIP-Seq_LS180_Human1.41095589
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.38615547
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38503690
58* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37245119
59* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36910510
60BRD4_25478319_ChIP-Seq_HGPS_Human1.35292915
61AHR_22903824_ChIP-Seq_MCF-7_Human1.34922637
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.34726708
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34398324
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33868058
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32733050
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.32503752
67* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.31474202
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31427557
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30892273
70* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30780921
71DROSHA_22980978_ChIP-Seq_HELA_Human1.30057644
72TCF4_22108803_ChIP-Seq_LS180_Human1.27522556
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.27052294
74SOX2_20726797_ChIP-Seq_SW620_Human1.26942189
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26828387
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26083614
77ZNF274_21170338_ChIP-Seq_K562_Hela1.25965935
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24510140
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23973959
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.23902781
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.23745858
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.23481031
83* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23373314
84SMAD4_21799915_ChIP-Seq_A2780_Human1.23263126
85CDX2_22108803_ChIP-Seq_LS180_Human1.22918340
86BCAT_22108803_ChIP-Seq_LS180_Human1.22866482
87EED_16625203_ChIP-ChIP_MESCs_Mouse1.22812044
88RUNX2_22187159_ChIP-Seq_PCA_Human1.22733200
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.22467651
90TP53_22573176_ChIP-Seq_HFKS_Human1.22197922
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.21744525
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20590795
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19578542
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.19185935
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.18807359
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.18807359
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18433195
98* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17351040
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17229701
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17188961
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17188961
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16388642
103CRX_20693478_ChIP-Seq_RETINA_Mouse1.16175667
104CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16123234
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.15890024
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15349368
107* NANOG_19829295_ChIP-Seq_ESCs_Human1.15241072
108* SOX2_19829295_ChIP-Seq_ESCs_Human1.15241072
109REST_21632747_ChIP-Seq_MESCs_Mouse1.15124570
110* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13202652
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12679469
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12665563
113TP63_23658742_ChIP-Seq_EP156T_Human1.12438925
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12258564
115* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11780052
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.11627187
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10822188
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.10744319
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10522499
120STAT3_23295773_ChIP-Seq_U87_Human1.09858183
121JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09459221
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.08135419
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08120271
124RNF2_27304074_Chip-Seq_NSC_Mouse1.08060879
125P53_22387025_ChIP-Seq_ESCs_Mouse1.07771372
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06820787
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.06753150
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06647009
129RARB_27405468_Chip-Seq_BRAIN_Mouse1.06450285
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06318744
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06204025
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.06162441
133FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05854941
134HTT_18923047_ChIP-ChIP_STHdh_Human1.05137430
135CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04760604
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04651358
137* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04468846
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03589368
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03242401
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02688576
141* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02438343
142EZH2_22144423_ChIP-Seq_EOC_Human1.01746156
143TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01508260
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.01230265
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01230265
146AR_25329375_ChIP-Seq_VCAP_Human1.00965097
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.99678244
148JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99543247
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.99425540
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.98967740
151HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98747177
152JUN_21703547_ChIP-Seq_K562_Human0.98560496
153KLF5_25053715_ChIP-Seq_YYC3_Human0.98526248
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.97569413
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97496371
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96007415
157SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95862580
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95832642
159* P300_19829295_ChIP-Seq_ESCs_Human0.94776398
160SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93606460
161RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92132149
162AR_19668381_ChIP-Seq_PC3_Human0.91907892
163P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91310639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.21052152
2MP0003705_abnormal_hypodermis_morpholog4.35717070
3MP0005623_abnormal_meninges_morphology3.65314055
4MP0010234_abnormal_vibrissa_follicle3.65084477
5MP0005275_abnormal_skin_tensile3.49562569
6MP0009780_abnormal_chondrocyte_physiolo2.86842246
7MP0003011_delayed_dark_adaptation2.81726447
8MP0004859_abnormal_synaptic_plasticity2.75505067
9MP0005551_abnormal_eye_electrophysiolog2.74641222
10MP0008877_abnormal_DNA_methylation2.53724678
11MP0005503_abnormal_tendon_morphology2.45877636
12MP0003091_abnormal_cell_migration2.43142687
13MP0002876_abnormal_thyroid_physiology2.42899457
14MP0001968_abnormal_touch/_nociception2.42626713
15MP0002877_abnormal_melanocyte_morpholog2.41475501
16MP0004272_abnormal_basement_membrane2.41420311
17MP0009384_cardiac_valve_regurgitation2.38878709
18MP0002102_abnormal_ear_morphology2.37896979
19MP0005646_abnormal_pituitary_gland2.31488543
20MP0002837_dystrophic_cardiac_calcinosis2.28651744
21MP0005645_abnormal_hypothalamus_physiol2.20461133
22MP0006072_abnormal_retinal_apoptosis2.19846659
23MP0003300_gastrointestinal_ulcer2.19114720
24MP0001501_abnormal_sleep_pattern2.18499593
25MP0000569_abnormal_digit_pigmentation2.18280138
26MP0001299_abnormal_eye_distance/2.13144843
27MP0002896_abnormal_bone_mineralization2.12447288
28MP0002736_abnormal_nociception_after2.04716973
29MP0000013_abnormal_adipose_tissue2.02393644
30MP0001958_emphysema2.01376980
31MP0004043_abnormal_pH_regulation1.97394593
32MP0005253_abnormal_eye_physiology1.93190573
33MP0000733_abnormal_muscle_development1.87772975
34MP0003880_abnormal_central_pattern1.85979259
35MP0010352_gastrointestinal_tract_polyps1.83668322
36MP0005174_abnormal_tail_pigmentation1.75484494
37MP0002272_abnormal_nervous_system1.74094527
38MP0003045_fibrosis1.69514790
39MP0002638_abnormal_pupillary_reflex1.68632242
40MP0004885_abnormal_endolymph1.64187433
41MP0002735_abnormal_chemical_nociception1.63851018
42MP0003787_abnormal_imprinting1.59058215
43MP0004185_abnormal_adipocyte_glucose1.58980795
44MP0004270_analgesia1.58362930
45MP0000538_abnormal_urinary_bladder1.57678640
46MP0010678_abnormal_skin_adnexa1.56431444
47MP0005360_urolithiasis1.55102423
48MP0001986_abnormal_taste_sensitivity1.53527471
49MP0001485_abnormal_pinna_reflex1.50605790
50MP0001486_abnormal_startle_reflex1.47461984
51MP0002060_abnormal_skin_morphology1.45778935
52MP0000372_irregular_coat_pigmentation1.45535687
53MP0001177_atelectasis1.42839984
54MP0002557_abnormal_social/conspecific_i1.42797974
55MP0008872_abnormal_physiological_respon1.42276815
56MP0005379_endocrine/exocrine_gland_phen1.39585173
57MP0006054_spinal_hemorrhage1.39338881
58MP0001984_abnormal_olfaction1.33945670
59MP0001919_abnormal_reproductive_system1.33003346
60MP0005076_abnormal_cell_differentiation1.32376045
61MP0002572_abnormal_emotion/affect_behav1.30712285
62MP0000230_abnormal_systemic_arterial1.28202978
63MP0002734_abnormal_mechanical_nocicepti1.27380645
64MP0005389_reproductive_system_phenotype1.26100835
65MP0005647_abnormal_sex_gland1.25980366
66MP0003279_aneurysm1.24903087
67MP0002160_abnormal_reproductive_system1.24311784
68MP0003635_abnormal_synaptic_transmissio1.24120017
69MP0005257_abnormal_intraocular_pressure1.23266025
70MP0001970_abnormal_pain_threshold1.22119722
71* MP0004924_abnormal_behavior1.22080671
72* MP0005386_behavior/neurological_phenoty1.22080671
73MP0003566_abnormal_cell_adhesion1.21798889
74MP0001944_abnormal_pancreas_morphology1.21588861
75MP0004145_abnormal_muscle_electrophysio1.20889537
76MP0002163_abnormal_gland_morphology1.20052255
77MP0005332_abnormal_amino_acid1.19798251
78MP0000751_myopathy1.17348721
79MP0000631_abnormal_neuroendocrine_gland1.16308718
80MP0005085_abnormal_gallbladder_physiolo1.15912450
81MP0003879_abnormal_hair_cell1.15902111
82MP0000015_abnormal_ear_pigmentation1.15018202
83MP0005187_abnormal_penis_morphology1.14876680
84MP0000537_abnormal_urethra_morphology1.14021030
85MP0000613_abnormal_salivary_gland1.13659952
86MP0005310_abnormal_salivary_gland1.13136440
87MP0004142_abnormal_muscle_tone1.12812195
88MP0005508_abnormal_skeleton_morphology1.12489143
89MP0005410_abnormal_fertilization1.12135495
90MP0003283_abnormal_digestive_organ1.11802869
91MP0001756_abnormal_urination1.10647356
92MP0004858_abnormal_nervous_system1.09683944
93MP0001765_abnormal_ion_homeostasis1.08895649
94MP0002115_abnormal_skeleton_extremities1.07817667
95MP0010329_abnormal_lipoprotein_level1.06972098
96MP0002693_abnormal_pancreas_physiology1.05248794
97MP0002998_abnormal_bone_remodeling1.04961938
98MP0001764_abnormal_homeostasis1.04811599
99MP0002168_other_aberrant_phenotype1.04237096
100MP0002229_neurodegeneration1.03820061
101MP0002295_abnormal_pulmonary_circulatio1.03295961
102MP0002733_abnormal_thermal_nociception1.03150280
103MP0005171_absent_coat_pigmentation1.02874646
104MP0009250_abnormal_appendicular_skeleto1.02167906
105MP0004130_abnormal_muscle_cell1.01874405
106MP0003950_abnormal_plasma_membrane1.00473577
107MP0005167_abnormal_blood-brain_barrier1.00467301
108MP0002928_abnormal_bile_duct0.98946641
109MP0002938_white_spotting0.98752924
110* MP0002067_abnormal_sensory_capabilities0.97495175
111MP0003121_genomic_imprinting0.97319854
112MP0000003_abnormal_adipose_tissue0.95639373
113MP0003633_abnormal_nervous_system0.95509796
114MP0002063_abnormal_learning/memory/cond0.95217974
115MP0000428_abnormal_craniofacial_morphol0.95205536
116MP0004233_abnormal_muscle_weight0.94393592
117MP0003329_amyloid_beta_deposits0.94262915
118MP0003385_abnormal_body_wall0.93332048
119MP0000427_abnormal_hair_cycle0.93269624
120MP0002653_abnormal_ependyma_morphology0.93216369
121* MP0001881_abnormal_mammary_gland0.92769506
122MP0000371_diluted_coat_color0.91685982
123MP0003252_abnormal_bile_duct0.91350288
124MP0002108_abnormal_muscle_morphology0.90772671
125MP0000163_abnormal_cartilage_morphology0.90133128
126MP0004085_abnormal_heartbeat0.89593932
127MP0004019_abnormal_vitamin_homeostasis0.88862590
128MP0005365_abnormal_bile_salt0.87324247
129MP0000516_abnormal_urinary_system0.87309770
130MP0005367_renal/urinary_system_phenotyp0.87309770
131MP0002234_abnormal_pharynx_morphology0.87136446
132MP0010386_abnormal_urinary_bladder0.86621506
133MP0004147_increased_porphyrin_level0.86134584
134MP0005023_abnormal_wound_healing0.86057574
135MP0000747_muscle_weakness0.85936922
136MP0005248_abnormal_Harderian_gland0.84706231
137MP0001502_abnormal_circadian_rhythm0.84269470
138MP0000639_abnormal_adrenal_gland0.83048162
139MP0003453_abnormal_keratinocyte_physiol0.82959704
140MP0001905_abnormal_dopamine_level0.82944652
141MP0005220_abnormal_exocrine_pancreas0.82918679
142MP0002796_impaired_skin_barrier0.82547042
143MP0002133_abnormal_respiratory_system0.82170041
144MP0005388_respiratory_system_phenotype0.82170041
145MP0002822_catalepsy0.82029149
146MP0010307_abnormal_tumor_latency0.81379160
147MP0003115_abnormal_respiratory_system0.80393842
148MP0000534_abnormal_ureter_morphology0.79898950
149MP0002909_abnormal_adrenal_gland0.79425419
150MP0003303_peritoneal_inflammation0.79373604
151MP0002090_abnormal_vision0.78759999
152MP0010771_integument_phenotype0.76464937
153MP0001849_ear_inflammation0.76407556
154MP0000383_abnormal_hair_follicle0.75818116
155MP0002113_abnormal_skeleton_development0.75514781
156MP0004087_abnormal_muscle_fiber0.75360316
157MP0000767_abnormal_smooth_muscle0.74884108
158MP0008004_abnormal_stomach_pH0.74102918
159MP0002254_reproductive_system_inflammat0.74057053
160MP0002089_abnormal_postnatal_growth/wei0.73311575
161MP0003937_abnormal_limbs/digits/tail_de0.72630598
162MP0001243_abnormal_dermal_layer0.72302592
163MP0000604_amyloidosis0.72164017
164MP0001542_abnormal_bone_strength0.72129514
165* MP0000627_abnormal_mammary_gland0.71952342
166MP0002282_abnormal_trachea_morphology0.71730792
167MP0009053_abnormal_anal_canal0.69903833
168MP0009745_abnormal_behavioral_response0.69758261
169MP0004134_abnormal_chest_morphology0.68248795
170MP0003195_calcinosis0.67702747
171MP0002064_seizures0.67128017
172MP0004510_myositis0.66534274
173MP0005375_adipose_tissue_phenotype0.66288790
174MP0003755_abnormal_palate_morphology0.65441238
175MP0009046_muscle_twitch0.65386499
176MP0001440_abnormal_grooming_behavior0.64508033
177MP0001348_abnormal_lacrimal_gland0.64321501
178MP0002009_preneoplasia0.62655757
179MP0003795_abnormal_bone_structure0.62393658

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.75424370
2Hyperventilation (HP:0002883)4.14129521
3Protrusio acetabuli (HP:0003179)4.08846419
4Pancreatic cysts (HP:0001737)3.80359258
5Hypothermia (HP:0002045)3.78466310
6Ketoacidosis (HP:0001993)3.76027265
7Congenital stationary night blindness (HP:0007642)3.72585906
8Renal cortical cysts (HP:0000803)3.68266093
9Abnormality of the renal cortex (HP:0011035)3.61996176
10Pancreatic fibrosis (HP:0100732)3.52137666
11Medial flaring of the eyebrow (HP:0010747)3.23812082
12Cervical subluxation (HP:0003308)3.21818646
13Atrophic scars (HP:0001075)3.17124401
14True hermaphroditism (HP:0010459)3.16410843
15Ankle contracture (HP:0006466)3.15914806
16Nephronophthisis (HP:0000090)3.15623955
17Attenuation of retinal blood vessels (HP:0007843)3.14901341
18Shallow orbits (HP:0000586)3.14784881
19Gaze-evoked nystagmus (HP:0000640)3.13487360
20Subacute progressive viral hepatitis (HP:0006572)3.11867271
21Abnormality of midbrain morphology (HP:0002418)3.11519676
22Molar tooth sign on MRI (HP:0002419)3.11519676
23Aortic dissection (HP:0002647)2.95551931
24Ketosis (HP:0001946)2.83731374
25Cerebral aneurysm (HP:0004944)2.83230167
26Dilatation of the ascending aorta (HP:0005111)2.76071439
27Abnormality of the renal medulla (HP:0100957)2.75890963
28Buphthalmos (HP:0000557)2.75747286
29Aortic aneurysm (HP:0004942)2.67494339
30Congenital sensorineural hearing impairment (HP:0008527)2.66062433
31Gait imbalance (HP:0002141)2.65792219
32Type 1 muscle fiber predominance (HP:0003803)2.63686781
33Osteolytic defects of the hand bones (HP:0009699)2.63190806
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.63190806
35Congenital primary aphakia (HP:0007707)2.59361223
36Type II lissencephaly (HP:0007260)2.57408650
37Mitral valve prolapse (HP:0001634)2.56733503
38Progressive cerebellar ataxia (HP:0002073)2.54534807
39Follicular hyperkeratosis (HP:0007502)2.53167461
40Fragile skin (HP:0001030)2.50107364
41Broad-based gait (HP:0002136)2.48838805
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.45609146
43Absent speech (HP:0001344)2.45608059
44Cupped ribs (HP:0000887)2.45384457
45Peritonitis (HP:0002586)2.42596165
46Abolished electroretinogram (ERG) (HP:0000550)2.42548627
47Fair hair (HP:0002286)2.42531397
48Absent frontal sinuses (HP:0002688)2.41989603
49Abnormal rod and cone electroretinograms (HP:0008323)2.40337468
50Febrile seizures (HP:0002373)2.39395798
51Large for gestational age (HP:0001520)2.38048070
52Hemiparesis (HP:0001269)2.37392529
53Mildly elevated creatine phosphokinase (HP:0008180)2.37068769
54Tubular atrophy (HP:0000092)2.36481948
55Increased connective tissue (HP:0009025)2.36062056
56Methylmalonic acidemia (HP:0002912)2.35533880
57Neonatal short-limb short stature (HP:0008921)2.34593207
58Hamartoma of the eye (HP:0010568)2.33752008
59Cystic liver disease (HP:0006706)2.33213713
60Overgrowth (HP:0001548)2.31093847
61Nephrogenic diabetes insipidus (HP:0009806)2.31078711
62Genu recurvatum (HP:0002816)2.29995045
63Inability to walk (HP:0002540)2.28932095
64Macroorchidism (HP:0000053)2.28843099
65Furrowed tongue (HP:0000221)2.28360104
66Wormian bones (HP:0002645)2.27795365
67Chronic hepatic failure (HP:0100626)2.27207384
68Abnormality of the axillary hair (HP:0100134)2.26551045
69Abnormality of secondary sexual hair (HP:0009888)2.26551045
70Vascular tortuosity (HP:0004948)2.25572990
71Enlarged penis (HP:0000040)2.24312573
72Lower limb amyotrophy (HP:0007210)2.24056224
73Spinal rigidity (HP:0003306)2.23440325
74Arterial tortuosity (HP:0005116)2.23160283
75Thyroiditis (HP:0100646)2.23134229
76Genetic anticipation (HP:0003743)2.21815816
77Scapular winging (HP:0003691)2.19497568
78Abnormality of macular pigmentation (HP:0008002)2.18888501
79Hyporeflexia of lower limbs (HP:0002600)2.18570646
80Short nail (HP:0001799)2.18375672
81Bladder diverticulum (HP:0000015)2.16759392
82Spinal cord compression (HP:0002176)2.16563338
83Ulnar bowing (HP:0003031)2.16557334
84Genital tract atresia (HP:0001827)2.15676442
85Generalized hypopigmentation of hair (HP:0011358)2.15642107
86Thin bony cortex (HP:0002753)2.14574117
87Keratoconus (HP:0000563)2.14170033
88Increased corneal curvature (HP:0100692)2.14170033
89Epiphyseal dysplasia (HP:0002656)2.13564972
90Bony spicule pigmentary retinopathy (HP:0007737)2.13004556
91Hyperglycinuria (HP:0003108)2.10005402
92Hypoalbuminemia (HP:0003073)2.09750429
93Abnormal albumin level (HP:0012116)2.09750429
94Increased variability in muscle fiber diameter (HP:0003557)2.08483264
95Slender build (HP:0001533)2.08183533
96Difficulty climbing stairs (HP:0003551)2.08131144
97Progressive inability to walk (HP:0002505)2.07792615
98Clumsiness (HP:0002312)2.07690884
99Protruding tongue (HP:0010808)2.07314464
100Abnormality of dentin (HP:0010299)2.06832132
101Polydipsia (HP:0001959)2.06521057
102Abnormal drinking behavior (HP:0030082)2.06521057
103Broad metatarsal (HP:0001783)2.06097066
104Abnormality of vitamin B metabolism (HP:0004340)2.06039218
105Hypoplastic ischia (HP:0003175)2.05996164
106Spinal cord lesions (HP:0100561)2.05338132
107Syringomyelia (HP:0003396)2.05338132
108Decreased circulating renin level (HP:0003351)2.04922325
109Abnormality of oral frenula (HP:0000190)2.04595491
110Deviation of the hallux (HP:0010051)2.04310871
111Increased density of long bones (HP:0006392)2.04236019
112Vaginal atresia (HP:0000148)2.03351758
113Distal upper limb amyotrophy (HP:0007149)2.02812074
114Upper limb amyotrophy (HP:0009129)2.02812074
115Distal lower limb amyotrophy (HP:0008944)2.02744044
116Tibial bowing (HP:0002982)2.02167649
117Termporal pattern (HP:0011008)2.01308473
118Insidious onset (HP:0003587)2.01308473
119Radial bowing (HP:0002986)2.00744472
120Soft skin (HP:0000977)1.99112214
121Pendular nystagmus (HP:0012043)1.98840468
122Resting tremor (HP:0002322)1.97928671
123Poor coordination (HP:0002370)1.97630804
124Hallux valgus (HP:0001822)1.96974060
125Ankyloglossia (HP:0010296)1.96937751
126Asymmetry of the thorax (HP:0001555)1.96731719
127Amelogenesis imperfecta (HP:0000705)1.95211407
128Coronal craniosynostosis (HP:0004440)1.94988194
129Short tibia (HP:0005736)1.94681037
130EEG with generalized epileptiform discharges (HP:0011198)1.92270244
131Prostate neoplasm (HP:0100787)1.91005460
132Bell-shaped thorax (HP:0001591)1.89652278
133Exostoses (HP:0100777)1.88771010
134Epileptiform EEG discharges (HP:0011182)1.88043819
135Infantile muscular hypotonia (HP:0008947)1.88018451
136Tachypnea (HP:0002789)1.87474598
137Focal motor seizures (HP:0011153)1.87458599
138Dialeptic seizures (HP:0011146)1.87237196
139Hyperextensible skin (HP:0000974)1.86752428
140Hypsarrhythmia (HP:0002521)1.86472697
141Decreased central vision (HP:0007663)1.86368871
142Focal seizures (HP:0007359)1.85700335
143Methylmalonic aciduria (HP:0012120)1.84471476
144Neoplasm of the adrenal cortex (HP:0100641)1.83579545
145Aneurysm (HP:0002617)1.83500241
146Small hand (HP:0200055)1.81137143
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.81122097
148Tented upper lip vermilion (HP:0010804)1.80728109
149Blue sclerae (HP:0000592)1.79709725
150Bile duct proliferation (HP:0001408)1.79279521
151Abnormal biliary tract physiology (HP:0012439)1.79279521
152Abnormality of the ischium (HP:0003174)1.79188913
153Postaxial hand polydactyly (HP:0001162)1.79043544
154Atonic seizures (HP:0010819)1.78106485
155Lymphangioma (HP:0100764)1.77603059
156Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77436706
157Micronodular cirrhosis (HP:0001413)1.77131062
158Azoospermia (HP:0000027)1.76404995
159Calf muscle hypertrophy (HP:0008981)1.76095917
160Abnormality of serine family amino acid metabolism (HP:0010894)1.75680110
161Abnormality of glycine metabolism (HP:0010895)1.75680110
162Bronchomalacia (HP:0002780)1.75625657
163Male pseudohermaphroditism (HP:0000037)1.75388247
164Adactyly (HP:0009776)1.75079369
165Bowel diverticulosis (HP:0005222)1.74963180
166Aplasia involving bones of the extremities (HP:0009825)1.74936834
167Aplasia involving bones of the upper limbs (HP:0009823)1.74936834
168Aplasia of the phalanges of the hand (HP:0009802)1.74936834
169Abnormality of skeletal muscle fiber size (HP:0012084)1.74761488
170Akinesia (HP:0002304)1.74684023
171Intestinal atresia (HP:0011100)1.74521728
172Hypoplasia of the uterus (HP:0000013)1.73965207
173Epileptic encephalopathy (HP:0200134)1.73226551
174Osteoarthritis (HP:0002758)1.73196925
175Congenital hepatic fibrosis (HP:0002612)1.72927477
176Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72879822
177Abnormality of alanine metabolism (HP:0010916)1.72879822
178Hyperalaninemia (HP:0003348)1.72879822
179Hypoglycemic coma (HP:0001325)1.72610054
180Congenital glaucoma (HP:0001087)1.72239239
181Hypoplasia of the fovea (HP:0007750)1.72143587
182Aplasia/Hypoplasia of the fovea (HP:0008060)1.72143587
183Elbow flexion contracture (HP:0002987)1.71879597
184Hematochezia (HP:0002573)1.71737405
185Gonadotropin excess (HP:0000837)1.71586330
186Anencephaly (HP:0002323)1.71444443
187Sclerocornea (HP:0000647)1.70606726
188Dysmetric saccades (HP:0000641)1.70054210
189Sensory axonal neuropathy (HP:0003390)1.68942239
190Abnormality of the frontal sinuses (HP:0002687)1.65381311
191Rectal prolapse (HP:0002035)1.65246502
192Broad ribs (HP:0000885)1.64289497
193Alopecia of scalp (HP:0002293)1.63759377
194Femoral bowing (HP:0002980)1.63224413
195Bowed forearm bones (HP:0003956)1.62649121
196Bowing of the arm (HP:0006488)1.62649121
197Papilledema (HP:0001085)1.61342211
198Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.61202026

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.20648578
2DDR23.63280274
3FRK3.60248850
4LATS13.42756377
5TRIB33.27958309
6MAPK132.98510703
7MAP4K22.90208995
8GRK12.82884294
9TTN2.73286510
10ADRBK22.65559788
11PKN22.55112214
12PDGFRA2.37945995
13ACVR1B2.21306208
14CASK2.20340969
15BMPR1B2.18628002
16PRKD32.11184368
17WNK32.04214476
18RIPK12.00771079
19PAK61.89791116
20MAP3K91.85384436
21CAMKK11.84116463
22EPHA41.76180540
23MOS1.73689181
24TAOK31.73241719
25MAP3K21.70344165
26CAMKK21.69328005
27TNK21.66648728
28WNK41.63963939
29PINK11.61948519
30NUAK11.60961940
31STK31.52525262
32NTRK31.49509134
33PLK21.49478384
34FGFR21.49379528
35SCYL21.49196507
36PDGFRB1.47840307
37FER1.44820869
38PAK31.42727286
39NTRK11.41410242
40TYRO31.37797281
41BMX1.29799032
42MET1.27055151
43PTK61.26129011
44TXK1.24912667
45PDK31.21701967
46PDK41.21701967
47PAK21.20494959
48MAPKAPK31.19600672
49RET1.19232297
50PRKD21.18505936
51PTK21.16587039
52SIK11.16495422
53EEF2K1.13777213
54TRIM281.12308155
55TRPM71.10995143
56SGK21.10655101
57INSRR1.07909632
58PTK2B1.07778107
59PDK21.06658275
60FGFR11.04105763
61DAPK21.03010665
62DMPK1.02238238
63KSR21.01695553
64MST1R0.98367261
65STK38L0.97198481
66MAP3K40.97154201
67LRRK20.95786591
68PNCK0.95286338
69EPHA30.93813753
70KSR10.90040835
71MAP2K70.89445490
72EIF2AK30.86158230
73PRKCH0.83678262
74TESK10.82895995
75ZAK0.82423634
76MAP3K30.80988648
77PDK10.80048464
78MAP2K10.79490763
79ROCK10.79486678
80EPHA20.78016679
81LATS20.78004269
82NLK0.77797230
83PDPK10.77448988
84MUSK0.77054501
85TLK10.76964235
86PIK3CA0.73376636
87GRK70.72946779
88CDK50.72000003
89PRKAA20.71141481
90CAMK1D0.71125483
91FGFR30.70969740
92ADRBK10.68011354
93LIMK10.66351170
94ROCK20.64875255
95SGK2230.64604534
96SGK4940.64604534
97PHKG20.63970561
98PHKG10.63970561
99JAK10.63446342
100CSNK1G10.62887706
101TAOK10.62882869
102NEK90.61429267
103CAMK1G0.60554883
104TEC0.60445016
105STK390.58149298
106MARK10.58126182
107CSNK1A1L0.57489817
108SGK10.57409151
109STK380.57183273
110FGR0.57103956
111PRKCG0.55497990
112ERBB30.53958367
113CDK140.53244641
114STK110.52794121
115INSR0.52641578
116WNK10.52532125
117SGK30.51693965
118EPHB20.50894395
119EPHB10.50242857
120PRKAA10.49887521
121MAP2K60.49510834
122MINK10.48757893
123CDK150.48549355
124OXSR10.47826856
125PRKCZ0.46809962
126CDK180.45408502
127LMTK20.45364062
128BRSK20.45062063
129MST40.44870165
130MAPKAPK50.44498756
131CDK60.44404267
132TNIK0.43867415
133DYRK1B0.43296693
134PRKCE0.43270884
135CHUK0.43268927
136CSNK1G20.42617453
137MTOR0.42515784
138CDC42BPA0.42291359
139IRAK10.42211814
140MKNK20.40510483
141CSNK1G30.40363692
142IKBKB0.40189714
143CAMK10.39700434
144RIPK40.39307508
145PRKACA0.38731610
146CAMK2A0.38344643
147ERBB40.38166942
148MAP3K70.38124755
149ALK0.38120953
150BCR0.38023605
151EGFR0.37960835
152PKN10.36743721
153ILK0.35920078
154CSNK1A10.35868976
155MAP2K40.35660492
156PRKD10.34380599
157GRK50.33213917
158CAMK2D0.29600891
159PRKCA0.27728646
160PRKCI0.27354469
161CSNK1D0.26612870
162ERBB20.26226413
163MYLK0.26193916
164ABL10.25781588
165HIPK20.23860735
166IGF1R0.22858839
167STK240.21422149

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.99114050
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59119248
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55242317
4Butanoate metabolism_Homo sapiens_hsa006502.51796649
5Phototransduction_Homo sapiens_hsa047442.51090120
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30774084
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24138321
8Linoleic acid metabolism_Homo sapiens_hsa005912.22957123
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16564467
10Tryptophan metabolism_Homo sapiens_hsa003802.08946328
11Propanoate metabolism_Homo sapiens_hsa006401.87160599
12Vitamin digestion and absorption_Homo sapiens_hsa049771.86481507
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.81040086
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.80975058
15ECM-receptor interaction_Homo sapiens_hsa045121.80013277
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.77769868
17Ether lipid metabolism_Homo sapiens_hsa005651.73840882
18Selenocompound metabolism_Homo sapiens_hsa004501.72864032
19Focal adhesion_Homo sapiens_hsa045101.68371883
20Caffeine metabolism_Homo sapiens_hsa002321.65847307
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59077086
22Protein export_Homo sapiens_hsa030601.50871205
23Long-term potentiation_Homo sapiens_hsa047201.50446772
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50198595
25Glioma_Homo sapiens_hsa052141.49315305
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46157689
27Peroxisome_Homo sapiens_hsa041461.45829241
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43935718
29Proteoglycans in cancer_Homo sapiens_hsa052051.43798979
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41055616
31Gastric acid secretion_Homo sapiens_hsa049711.39636342
32Salivary secretion_Homo sapiens_hsa049701.38800598
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37702524
34Renin secretion_Homo sapiens_hsa049241.34787783
35ABC transporters_Homo sapiens_hsa020101.34773038
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31245916
37Histidine metabolism_Homo sapiens_hsa003401.29560829
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.29371179
39Retinol metabolism_Homo sapiens_hsa008301.29291858
40Serotonergic synapse_Homo sapiens_hsa047261.28543698
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27098094
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.25909907
43Regulation of autophagy_Homo sapiens_hsa041401.24843657
44Fatty acid biosynthesis_Homo sapiens_hsa000611.23929242
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23041840
46Dilated cardiomyopathy_Homo sapiens_hsa054141.22559120
47Oxytocin signaling pathway_Homo sapiens_hsa049211.22145694
48Taste transduction_Homo sapiens_hsa047421.21797809
49Amphetamine addiction_Homo sapiens_hsa050311.20321526
50Basal transcription factors_Homo sapiens_hsa030221.20225171
51Circadian entrainment_Homo sapiens_hsa047131.19567766
52Circadian rhythm_Homo sapiens_hsa047101.19460327
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17757373
54GnRH signaling pathway_Homo sapiens_hsa049121.17689156
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16131168
56Axon guidance_Homo sapiens_hsa043601.15714069
57Chemical carcinogenesis_Homo sapiens_hsa052041.15584264
58Amoebiasis_Homo sapiens_hsa051461.15004211
59Estrogen signaling pathway_Homo sapiens_hsa049151.14952311
60Protein digestion and absorption_Homo sapiens_hsa049741.14605304
61mTOR signaling pathway_Homo sapiens_hsa041501.13955445
62Dorso-ventral axis formation_Homo sapiens_hsa043201.13485635
63ErbB signaling pathway_Homo sapiens_hsa040121.12339610
64Synaptic vesicle cycle_Homo sapiens_hsa047211.12313533
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12278955
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11155867
67Dopaminergic synapse_Homo sapiens_hsa047281.10813016
68Long-term depression_Homo sapiens_hsa047301.10136536
69Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08660609
70Tight junction_Homo sapiens_hsa045301.07922073
71Adherens junction_Homo sapiens_hsa045201.07701122
72Cholinergic synapse_Homo sapiens_hsa047251.07604068
73Insulin secretion_Homo sapiens_hsa049111.07549420
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.07111338
75beta-Alanine metabolism_Homo sapiens_hsa004101.06876317
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06862089
77Gap junction_Homo sapiens_hsa045401.06703128
78Olfactory transduction_Homo sapiens_hsa047401.04486476
79Glutamatergic synapse_Homo sapiens_hsa047241.03376372
80Type II diabetes mellitus_Homo sapiens_hsa049301.01207287
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01175922
82Fatty acid metabolism_Homo sapiens_hsa012121.00766008
83Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00418021
84Renal cell carcinoma_Homo sapiens_hsa052110.99339176
85Collecting duct acid secretion_Homo sapiens_hsa049660.98466184
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98454208
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95792351
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95089922
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92879182
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92746831
91GABAergic synapse_Homo sapiens_hsa047270.91232779
92Chronic myeloid leukemia_Homo sapiens_hsa052200.90209549
93Thyroid hormone synthesis_Homo sapiens_hsa049180.89829101
94Sphingolipid metabolism_Homo sapiens_hsa006000.89773233
95Fatty acid degradation_Homo sapiens_hsa000710.88158809
96VEGF signaling pathway_Homo sapiens_hsa043700.85647983
97Arachidonic acid metabolism_Homo sapiens_hsa005900.84992109
98Small cell lung cancer_Homo sapiens_hsa052220.84893149
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.83641712
100Cocaine addiction_Homo sapiens_hsa050300.83233579
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83198175
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.83055106
103Nicotine addiction_Homo sapiens_hsa050330.82986231
104Endocytosis_Homo sapiens_hsa041440.82796545
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82772875
106Morphine addiction_Homo sapiens_hsa050320.82628350
107Pancreatic secretion_Homo sapiens_hsa049720.82565880
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81094831
109Mineral absorption_Homo sapiens_hsa049780.80846289
110Platelet activation_Homo sapiens_hsa046110.80625194
111Sulfur metabolism_Homo sapiens_hsa009200.80100490
112Hippo signaling pathway_Homo sapiens_hsa043900.79694440
113Pancreatic cancer_Homo sapiens_hsa052120.79654035
114Prolactin signaling pathway_Homo sapiens_hsa049170.79543447
115Salmonella infection_Homo sapiens_hsa051320.76404536
116Rap1 signaling pathway_Homo sapiens_hsa040150.76046568
117MicroRNAs in cancer_Homo sapiens_hsa052060.74772795
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74667704
119Endometrial cancer_Homo sapiens_hsa052130.73888978
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73498874
121cAMP signaling pathway_Homo sapiens_hsa040240.72560660
122Bladder cancer_Homo sapiens_hsa052190.72372272
123Vibrio cholerae infection_Homo sapiens_hsa051100.72318380
124MAPK signaling pathway_Homo sapiens_hsa040100.71617578
125Arginine and proline metabolism_Homo sapiens_hsa003300.71509204
126Melanogenesis_Homo sapiens_hsa049160.71396138
127Nitrogen metabolism_Homo sapiens_hsa009100.71158778
128TNF signaling pathway_Homo sapiens_hsa046680.71072807
129Toxoplasmosis_Homo sapiens_hsa051450.70165674
130Ras signaling pathway_Homo sapiens_hsa040140.68982690
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.67569716
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67184085
133Melanoma_Homo sapiens_hsa052180.66874214
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.66717074
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.66705152
136Oxidative phosphorylation_Homo sapiens_hsa001900.65955308
137TGF-beta signaling pathway_Homo sapiens_hsa043500.63935390
138Inositol phosphate metabolism_Homo sapiens_hsa005620.63519930
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.63345462
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63239058
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62907784
142Ovarian steroidogenesis_Homo sapiens_hsa049130.62357887
143Renin-angiotensin system_Homo sapiens_hsa046140.61632155
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60887479
145Calcium signaling pathway_Homo sapiens_hsa040200.60185718
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60084227
147Choline metabolism in cancer_Homo sapiens_hsa052310.60078757
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.59063344
149Fat digestion and absorption_Homo sapiens_hsa049750.54616294
150Glycerolipid metabolism_Homo sapiens_hsa005610.51856369
151Bile secretion_Homo sapiens_hsa049760.44928280
152Metabolic pathways_Homo sapiens_hsa011000.44581576
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.41698618
154Type I diabetes mellitus_Homo sapiens_hsa049400.41577209
155Glucagon signaling pathway_Homo sapiens_hsa049220.35745468
156RNA degradation_Homo sapiens_hsa030180.34526930
157Lysine degradation_Homo sapiens_hsa003100.33689631
158Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33308950
159Intestinal immune network for IgA production_Homo sapiens_hsa046720.31510474
160Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29892360
161Fatty acid elongation_Homo sapiens_hsa000620.29208144
162Fanconi anemia pathway_Homo sapiens_hsa034600.28798219
163Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27226131

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