SLC30A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.67574159
2Golgi transport vesicle coating (GO:0048200)6.67574159
3nuclear pore complex assembly (GO:0051292)4.74091473
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.68152534
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54476360
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54476360
7iron ion import (GO:0097286)4.39753138
8COPII vesicle coating (GO:0048208)4.33571682
9nuclear pore organization (GO:0006999)4.27613262
10folic acid-containing compound biosynthetic process (GO:0009396)4.17199949
11protein retention in ER lumen (GO:0006621)4.12022512
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.06384586
13positive regulation of nuclease activity (GO:0032075)4.06354107
14antigen processing and presentation of endogenous antigen (GO:0019883)3.92340380
15UDP-N-acetylglucosamine metabolic process (GO:0006047)3.86286645
16cell adhesion mediated by integrin (GO:0033627)3.83994020
17ER overload response (GO:0006983)3.77704573
18regulation of nuclease activity (GO:0032069)3.75314791
19endoplasmic reticulum unfolded protein response (GO:0030968)3.64728741
20ribosome assembly (GO:0042255)3.54357413
21cellular response to unfolded protein (GO:0034620)3.50468561
22pore complex assembly (GO:0046931)3.46206161
23ER-nucleus signaling pathway (GO:0006984)3.37210036
244-hydroxyproline metabolic process (GO:0019471)3.35426552
25regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.30491861
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30107406
27cellular response to topologically incorrect protein (GO:0035967)3.29487831
28pentose-phosphate shunt (GO:0006098)3.27233659
29valine metabolic process (GO:0006573)3.25825732
30pyrimidine-containing compound transmembrane transport (GO:0072531)3.16778815
31folic acid metabolic process (GO:0046655)3.09223545
32vesicle coating (GO:0006901)3.06026915
33proline biosynthetic process (GO:0006561)3.04448857
34ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.97375379
35nucleotide-sugar biosynthetic process (GO:0009226)2.96302965
36sequestering of metal ion (GO:0051238)2.94196863
37tetrahydrofolate metabolic process (GO:0046653)2.94127405
38hyaluronan catabolic process (GO:0030214)2.93970763
39NADPH regeneration (GO:0006740)2.93716845
40lysine metabolic process (GO:0006553)2.93593635
41lysine catabolic process (GO:0006554)2.93593635
42DNA unwinding involved in DNA replication (GO:0006268)2.91562169
43membrane protein ectodomain proteolysis (GO:0006509)2.90383727
44signal peptide processing (GO:0006465)2.88683501
45tricarboxylic acid metabolic process (GO:0072350)2.87553877
46positive regulation of B cell differentiation (GO:0045579)2.86220721
47chondrocyte development (GO:0002063)2.85543634
48response to endoplasmic reticulum stress (GO:0034976)2.84808839
49protein N-linked glycosylation via asparagine (GO:0018279)2.82152592
50protein maturation by protein folding (GO:0022417)2.82021043
51peptidyl-asparagine modification (GO:0018196)2.81365248
52mRNA cleavage (GO:0006379)2.80800417
53cysteine metabolic process (GO:0006534)2.79231171
54intestinal cholesterol absorption (GO:0030299)2.78375137
55regulation of translational fidelity (GO:0006450)2.70812317
56regulation of centriole replication (GO:0046599)2.69506467
57oligosaccharide catabolic process (GO:0009313)2.69371604
58protein hydroxylation (GO:0018126)2.68947650
59folic acid-containing compound metabolic process (GO:0006760)2.68786037
60homocysteine metabolic process (GO:0050667)2.68272597
61pteridine-containing compound biosynthetic process (GO:0042559)2.67960691
62intestinal absorption (GO:0050892)2.67057265
63regulation of gamma-delta T cell differentiation (GO:0045586)2.66780549
64L-alpha-amino acid transmembrane transport (GO:1902475)2.66549949
65regulation of RNA export from nucleus (GO:0046831)2.65565766
66positive regulation of histone deacetylation (GO:0031065)2.64443592
67one-carbon metabolic process (GO:0006730)2.63940911
68peptidyl-proline hydroxylation (GO:0019511)2.63270514
69lipopolysaccharide biosynthetic process (GO:0009103)2.63208147
70nucleobase-containing small molecule interconversion (GO:0015949)2.62861413
71hemidesmosome assembly (GO:0031581)2.60807657
72positive regulation of gamma-delta T cell activation (GO:0046645)2.60175285
73hypotonic response (GO:0006971)2.59204749
74response to unfolded protein (GO:0006986)2.58800515
75AMP metabolic process (GO:0046033)2.58796726
76protein N-linked glycosylation (GO:0006487)2.58686901
77maternal placenta development (GO:0001893)2.56531923
78glycine metabolic process (GO:0006544)2.55233308
79alpha-linolenic acid metabolic process (GO:0036109)2.54080639
80vitamin transmembrane transport (GO:0035461)2.53592582
81desmosome organization (GO:0002934)2.53342849
82sphingosine metabolic process (GO:0006670)2.51238141
83oligosaccharide biosynthetic process (GO:0009312)2.50712117
84aspartate family amino acid biosynthetic process (GO:0009067)2.50406494
85regulation of keratinocyte differentiation (GO:0045616)2.50220696
86regulation of cholesterol homeostasis (GO:2000188)2.49955543
87serine family amino acid biosynthetic process (GO:0009070)2.49510870
88antigen processing and presentation via MHC class Ib (GO:0002475)2.49364157
89sphingomyelin metabolic process (GO:0006684)2.49269609
90lipopolysaccharide metabolic process (GO:0008653)2.48633668
91protein autoprocessing (GO:0016540)2.48584593
92urate metabolic process (GO:0046415)2.48554885
93response to topologically incorrect protein (GO:0035966)2.47318689
94sulfur amino acid catabolic process (GO:0000098)2.46830898
95regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.46505241
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45484315
97regulation of translational elongation (GO:0006448)2.45283723
98peptidyl-arginine omega-N-methylation (GO:0035247)2.45220705
99regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.44190614
100drug transmembrane transport (GO:0006855)2.44035271
101regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.43751901
102negative regulation of phagocytosis (GO:0050765)2.43061631
103mitochondrial DNA metabolic process (GO:0032042)2.42406667
104protein localization to cell surface (GO:0034394)2.41899601
105B cell receptor signaling pathway (GO:0050853)2.41867195
106regulation of B cell differentiation (GO:0045577)2.41857766
107tRNA aminoacylation for protein translation (GO:0006418)2.41023516
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.39404961
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37845929
110diol metabolic process (GO:0034311)2.37658372
111endoplasmic reticulum organization (GO:0007029)2.37657411
112amino acid activation (GO:0043038)2.37338075
113tRNA aminoacylation (GO:0043039)2.37338075
114glucose catabolic process (GO:0006007)2.36929597
115Golgi organization (GO:0007030)2.36319402
116carnitine transport (GO:0015879)2.36264380
117amino-acid betaine transport (GO:0015838)2.36264380
118positive regulation of keratinocyte differentiation (GO:0045618)2.36073703
119regulation of integrin activation (GO:0033623)2.35222553
120keratan sulfate catabolic process (GO:0042340)2.35197985
121protein localization to kinetochore (GO:0034501)2.32931305
122peptide catabolic process (GO:0043171)2.32454876
123drug transport (GO:0015893)2.32307266
124embryonic process involved in female pregnancy (GO:0060136)2.30565798
125negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.29478850
126UMP biosynthetic process (GO:0006222)2.29354000
127pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.29354000
128UMP metabolic process (GO:0046049)2.29354000
129pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.29354000
130nucleotide-sugar metabolic process (GO:0009225)2.28638032
131polarized epithelial cell differentiation (GO:0030859)2.28410976
1322-oxoglutarate metabolic process (GO:0006103)2.28342534
133chaperone-mediated protein folding (GO:0061077)2.28092487
134regulation of centrosome duplication (GO:0010824)2.27612436
135establishment of protein localization to vacuole (GO:0072666)2.27460843
136protein targeting to vacuole (GO:0006623)2.27460843
137protein targeting to lysosome (GO:0006622)2.27460843
138endocrine pancreas development (GO:0031018)2.27180379
139L-phenylalanine catabolic process (GO:0006559)2.26496417
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.26496417
141serine family amino acid metabolic process (GO:0009069)2.26135101
142sequestering of extracellular ligand from receptor (GO:0035581)2.25811976
143negative regulation of protein localization to plasma membrane (GO:1903077)2.25516245
144regulation of response to tumor cell (GO:0002834)2.25216992
145positive regulation of response to tumor cell (GO:0002836)2.25216992
146positive regulation of immune response to tumor cell (GO:0002839)2.25216992
147regulation of immune response to tumor cell (GO:0002837)2.25216992
148IMP biosynthetic process (GO:0006188)2.25101784
149paraxial mesoderm development (GO:0048339)2.24662022
150beta-amyloid metabolic process (GO:0050435)2.24557958
151pteridine-containing compound metabolic process (GO:0042558)2.24146007
152regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.23915959
153membrane protein proteolysis (GO:0033619)2.23575967
154mitochondrial DNA replication (GO:0006264)2.23326662
155negative regulation of striated muscle cell apoptotic process (GO:0010664)2.23120438
156androgen biosynthetic process (GO:0006702)2.22330068
157cellular modified amino acid catabolic process (GO:0042219)2.21482559
158positive regulation of triglyceride biosynthetic process (GO:0010867)2.21060121
159negative regulation of bone resorption (GO:0045779)2.20321470
160negative regulation of homotypic cell-cell adhesion (GO:0034111)2.20299369
161L-phenylalanine metabolic process (GO:0006558)2.20183628
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.20183628
163polyamine biosynthetic process (GO:0006596)2.19925992
164regulation of B cell receptor signaling pathway (GO:0050855)2.19861309
165leukocyte tethering or rolling (GO:0050901)2.19162550
166exocrine pancreas development (GO:0031017)2.18970605
167regulation of translational termination (GO:0006449)2.17483972
168carnitine transmembrane transport (GO:1902603)2.17437368
169regulation of transforming growth factor beta2 production (GO:0032909)2.17075537
170mannose metabolic process (GO:0006013)2.16194864
171establishment of apical/basal cell polarity (GO:0035089)2.14893299
172organ regeneration (GO:0031100)2.14348599
173ER to Golgi vesicle-mediated transport (GO:0006888)2.14123265
174aromatic amino acid family catabolic process (GO:0009074)2.13138380
175chaperone mediated protein folding requiring cofactor (GO:0051085)2.12855862
176fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.12588400
177histone-serine phosphorylation (GO:0035404)2.11220601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.39853901
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.53296359
3ZNF263_19887448_ChIP-Seq_K562_Human3.55799899
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52767119
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.24977078
6MYC_22102868_ChIP-Seq_BL_Human2.97456923
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.76985585
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71627793
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56401518
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.55701859
11GATA1_22025678_ChIP-Seq_K562_Human2.55361194
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.54307120
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50909276
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.46324725
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.33815123
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30263353
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.13817225
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08392208
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01311274
20* MYC_18555785_ChIP-Seq_MESCs_Mouse1.99559700
21CLOCK_20551151_ChIP-Seq_293T_Human1.98784073
22VDR_21846776_ChIP-Seq_THP-1_Human1.97658582
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95542933
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87856772
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85962445
26AR_21909140_ChIP-Seq_LNCAP_Human1.78903753
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77229047
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76175440
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.73901920
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72787121
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.70655566
32SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69716516
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69485056
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67199091
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64424567
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.63479919
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.60233021
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.60233021
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59467746
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59412469
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58798035
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.56930378
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56738960
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54345370
45* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53570550
46TFEB_21752829_ChIP-Seq_HELA_Human1.53514635
47* MYB_26560356_Chip-Seq_TH2_Human1.53147153
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50247689
49FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49290346
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49107910
51* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48779800
52MYB_26560356_Chip-Seq_TH1_Human1.44858617
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44582657
54SCL_19346495_ChIP-Seq_HPC-7_Human1.44378524
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44361967
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44285804
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43934174
58VDR_24763502_ChIP-Seq_THP-1_Human1.43154182
59SPI1_23547873_ChIP-Seq_NB4_Human1.43079059
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43015902
61* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42322684
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40851513
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40745855
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39756123
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.39597942
66UTX_26944678_Chip-Seq_JUKART_Human1.37507899
67* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37273388
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36938987
69MAF_26560356_Chip-Seq_TH1_Human1.36678626
70CIITA_25753668_ChIP-Seq_RAJI_Human1.36156871
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35814903
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34419025
73GATA6_25053715_ChIP-Seq_YYC3_Human1.33504590
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33458949
75TCF7_22412390_ChIP-Seq_EML_Mouse1.32563806
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32275500
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31073621
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.28541678
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28429179
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26774714
81* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26751750
82* BRD4_25478319_ChIP-Seq_HGPS_Human1.26591013
83* IRF8_27001747_Chip-Seq_BMDM_Mouse1.26209804
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25259422
85ELF5_23300383_ChIP-Seq_T47D_Human1.25098001
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24528894
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.24206805
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23134177
89GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22321860
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21073962
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21004240
92* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19347032
93KDM5A_27292631_Chip-Seq_BREAST_Human1.19014358
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18502522
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.17204381
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16919672
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.16503716
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15708944
99* VDR_23849224_ChIP-Seq_CD4+_Human1.15622079
100* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15220100
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15075786
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14372422
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14308030
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14104212
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13695157
106FOXP3_21729870_ChIP-Seq_TREG_Human1.13450770
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13200929
108IRF8_21731497_ChIP-ChIP_J774_Mouse1.11128259
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10469531
110* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10054660
111DCP1A_22483619_ChIP-Seq_HELA_Human1.09564157
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09231821
113GATA3_27048872_Chip-Seq_THYMUS_Human1.07815490
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07591958
115* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07128114
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06705820
117GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06334569
118GATA4_25053715_ChIP-Seq_YYC3_Human1.06227366
119CHD1_26751641_Chip-Seq_LNCaP_Human1.05615456
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04962599
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04388021
122XRN2_22483619_ChIP-Seq_HELA_Human1.04016991
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02267906
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01959931
125SOX2_20726797_ChIP-Seq_SW620_Human1.01924822
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01747277
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01711486
128* GABP_19822575_ChIP-Seq_HepG2_Human1.01219993
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01136895
130* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00635632
131UBF1/2_26484160_Chip-Seq_HMECs_Human1.00225042
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.00003846
133SOX17_20123909_ChIP-Seq_XEN_Mouse0.99770054
134FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99418881
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99042719
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.98746418
137* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98170266
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97914954
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97667815
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97286554
141CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97015331
142ELK1_19687146_ChIP-ChIP_HELA_Human0.96773185
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96076286
144NOTCH1_21737748_ChIP-Seq_TLL_Human0.95195636
145ATF3_27146783_Chip-Seq_COLON_Human0.95026033
146* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94491036
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.94336252
148* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93833322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis2.98865825
2MP0002139_abnormal_hepatobiliary_system2.94308542
3MP0004272_abnormal_basement_membrane2.89485721
4MP0006054_spinal_hemorrhage2.76392050
5MP0002877_abnormal_melanocyte_morpholog2.70053358
6MP0002009_preneoplasia2.67844146
7MP0003300_gastrointestinal_ulcer2.65926356
8MP0005365_abnormal_bile_salt2.39655721
9MP0009840_abnormal_foam_cell2.30298927
10MP0010352_gastrointestinal_tract_polyps2.17019060
11MP0010234_abnormal_vibrissa_follicle2.16411771
12MP0010678_abnormal_skin_adnexa2.04456705
13MP0001666_abnormal_nutrient_absorption2.03891623
14MP0005220_abnormal_exocrine_pancreas2.02836951
15MP0003705_abnormal_hypodermis_morpholog1.95921784
16MP0003693_abnormal_embryo_hatching1.87075176
17MP0003941_abnormal_skin_development1.83579644
18MP0003303_peritoneal_inflammation1.83357304
19MP0005085_abnormal_gallbladder_physiolo1.82750599
20MP0005058_abnormal_lysosome_morphology1.81943792
21MP0003252_abnormal_bile_duct1.79542033
22MP0004264_abnormal_extraembryonic_tissu1.70226296
23MP0002166_altered_tumor_susceptibility1.68391592
24MP0005451_abnormal_body_composition1.66715266
25MP0009697_abnormal_copulation1.64113986
26MP0000383_abnormal_hair_follicle1.62193899
27MP0001835_abnormal_antigen_presentation1.60316012
28MP0002396_abnormal_hematopoietic_system1.54630445
29MP0005275_abnormal_skin_tensile1.52164165
30MP0002060_abnormal_skin_morphology1.48999559
31MP0005464_abnormal_platelet_physiology1.48286520
32MP0001849_ear_inflammation1.46962921
33MP0008004_abnormal_stomach_pH1.46766218
34MP0009643_abnormal_urine_homeostasis1.46157998
35MP0003191_abnormal_cellular_cholesterol1.44543414
36MP0008875_abnormal_xenobiotic_pharmacok1.44336112
37MP0000609_abnormal_liver_physiology1.42993589
38MP0001944_abnormal_pancreas_morphology1.42895721
39MP0001800_abnormal_humoral_immune1.41139303
40MP0003436_decreased_susceptibility_to1.40469575
41MP0010329_abnormal_lipoprotein_level1.40142020
42MP0010307_abnormal_tumor_latency1.39127060
43MP0000685_abnormal_immune_system1.38742790
44MP0004808_abnormal_hematopoietic_stem1.37359651
45MP0004782_abnormal_surfactant_physiolog1.35208698
46MP0003806_abnormal_nucleotide_metabolis1.34087450
47MP0002693_abnormal_pancreas_physiology1.33799387
48MP0004957_abnormal_blastocyst_morpholog1.33636374
49MP0000627_abnormal_mammary_gland1.31457911
50MP0003183_abnormal_peptide_metabolism1.29721530
51MP0002796_impaired_skin_barrier1.28521124
52MP0005501_abnormal_skin_physiology1.28116807
53MP0001216_abnormal_epidermal_layer1.26046959
54MP0005076_abnormal_cell_differentiation1.25878459
55MP0005083_abnormal_biliary_tract1.25722607
56MP0005332_abnormal_amino_acid1.23738692
57MP0002452_abnormal_antigen_presenting1.23315671
58MP0003763_abnormal_thymus_physiology1.23284746
59MP0001958_emphysema1.22646868
60MP0003868_abnormal_feces_composition1.21786616
61MP0002398_abnormal_bone_marrow1.21677267
62MP0000689_abnormal_spleen_morphology1.20733372
63MP0005408_hypopigmentation1.19996388
64MP0002160_abnormal_reproductive_system1.19567394
65MP0002138_abnormal_hepatobiliary_system1.19536857
66MP0001873_stomach_inflammation1.19486686
67MP0003195_calcinosis1.18155684
68MP0005623_abnormal_meninges_morphology1.17805980
69MP0001845_abnormal_inflammatory_respons1.17780962
70MP0008057_abnormal_DNA_replication1.17197609
71MP0000490_abnormal_crypts_of1.16434073
72MP0002006_tumorigenesis1.15548616
73MP0001790_abnormal_immune_system1.14542280
74MP0005387_immune_system_phenotype1.14542280
75MP0002254_reproductive_system_inflammat1.14040618
76MP0000465_gastrointestinal_hemorrhage1.13869965
77MP0010155_abnormal_intestine_physiology1.13428780
78MP0003315_abnormal_perineum_morphology1.12275001
79MP0002722_abnormal_immune_system1.11927832
80MP0005000_abnormal_immune_tolerance1.11898992
81MP0008932_abnormal_embryonic_tissue1.11446992
82MP0002420_abnormal_adaptive_immunity1.11113237
83MP0000598_abnormal_liver_morphology1.10609431
84MP0002723_abnormal_immune_serum1.09602027
85MP0002086_abnormal_extraembryonic_tissu1.09224922
86MP0009333_abnormal_splenocyte_physiolog1.08857751
87MP0004185_abnormal_adipocyte_glucose1.08706051
88MP0001819_abnormal_immune_cell1.07930829
89MP0001243_abnormal_dermal_layer1.06730469
90MP0002419_abnormal_innate_immunity1.06683911
91MP0003566_abnormal_cell_adhesion1.05763960
92MP0001672_abnormal_embryogenesis/_devel1.05249196
93MP0005380_embryogenesis_phenotype1.05249196
94MP0005671_abnormal_response_to1.04719180
95MP0000358_abnormal_cell_content/1.04241319
96MP0004947_skin_inflammation1.03953099
97MP0003984_embryonic_growth_retardation1.03921953
98MP0005503_abnormal_tendon_morphology1.02935163
99MP0000716_abnormal_immune_system1.02899304
100MP0002098_abnormal_vibrissa_morphology1.02750166
101MP0002088_abnormal_embryonic_growth/wei1.01908308
102MP0003091_abnormal_cell_migration1.01009519
103MP0001881_abnormal_mammary_gland0.99841611
104MP0000537_abnormal_urethra_morphology0.99840243
105MP0005319_abnormal_enzyme/_coenzyme0.99647196
106MP0002429_abnormal_blood_cell0.99326616
107MP0008469_abnormal_protein_level0.98451270
108MP0008438_abnormal_cutaneous_collagen0.98382902
109MP0009384_cardiac_valve_regurgitation0.97089941
110MP0001661_extended_life_span0.97019200
111MP0003866_abnormal_defecation0.96646461
112MP0003172_abnormal_lysosome_physiology0.96281674
113MP0002136_abnormal_kidney_physiology0.96082215
114MP0010094_abnormal_chromosome_stability0.94507565
115MP0002896_abnormal_bone_mineralization0.94080012
116MP0003656_abnormal_erythrocyte_physiolo0.93508725
117MP0008007_abnormal_cellular_replicative0.93138011
118MP0001730_embryonic_growth_arrest0.93050919
119MP0005025_abnormal_response_to0.92694385
120MP0004084_abnormal_cardiac_muscle0.92459838
121MP0003123_paternal_imprinting0.91189226
122MP0005647_abnormal_sex_gland0.91052467
123MP0004233_abnormal_muscle_weight0.90870306
124MP0002019_abnormal_tumor_incidence0.90498456
125MP0000427_abnormal_hair_cycle0.90113665
126MP0002084_abnormal_developmental_patter0.89704670
127MP0000371_diluted_coat_color0.89535483
128MP0000703_abnormal_thymus_morphology0.88673932
129MP0002928_abnormal_bile_duct0.88190677
130MP0001533_abnormal_skeleton_physiology0.86997801
131MP0000377_abnormal_hair_follicle0.86193973
132MP0003077_abnormal_cell_cycle0.86084411
133MP0004043_abnormal_pH_regulation0.85758957
134MP0002078_abnormal_glucose_homeostasis0.85583759
135MP0002132_abnormal_respiratory_system0.84803086
136MP0009780_abnormal_chondrocyte_physiolo0.84359435
137MP0001919_abnormal_reproductive_system0.83845779
138MP0005023_abnormal_wound_healing0.83208265
139MP0000569_abnormal_digit_pigmentation0.83034189
140MP0002405_respiratory_system_inflammati0.83008356
141MP0005310_abnormal_salivary_gland0.82916360
142MP0003453_abnormal_keratinocyte_physiol0.82710531
143MP0003111_abnormal_nucleus_morphology0.82132389
144MP0005636_abnormal_mineral_homeostasis0.81657371
145MP0005397_hematopoietic_system_phenotyp0.81651506
146MP0001545_abnormal_hematopoietic_system0.81651506
147MP0000858_altered_metastatic_potential0.81430975
148* MP0003795_abnormal_bone_structure0.79963159
149MP0002933_joint_inflammation0.79819370
150MP0002876_abnormal_thyroid_physiology0.79039544
151MP0005621_abnormal_cell_physiology0.78323255
152MP0002118_abnormal_lipid_homeostasis0.78234392
153MP0005389_reproductive_system_phenotype0.77076990
154MP0001697_abnormal_embryo_size0.76443914
155MP0000350_abnormal_cell_proliferation0.74069564
156MP0010368_abnormal_lymphatic_system0.72267709
157MP0000013_abnormal_adipose_tissue0.72267372
158MP0002080_prenatal_lethality0.71647809
159MP0005384_cellular_phenotype0.71165058
160MP0002092_abnormal_eye_morphology0.70563859
161MP0010771_integument_phenotype0.69908979
162MP0005171_absent_coat_pigmentation0.68209287
163MP0000762_abnormal_tongue_morphology0.67730968
164MP0000681_abnormal_thyroid_gland0.67161401
165MP0001348_abnormal_lacrimal_gland0.67007462

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.63926865
2Hypoglycemic coma (HP:0001325)3.72974428
3Short nail (HP:0001799)3.15516222
4Abnormality of glycolipid metabolism (HP:0010969)3.11316875
5Abnormality of liposaccharide metabolism (HP:0010968)3.11316875
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.11316875
7Hypoglycemic seizures (HP:0002173)2.93450044
8Abnormality of the common coagulation pathway (HP:0010990)2.91986013
9Abnormality of the intrinsic pathway (HP:0010989)2.91421686
10Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.80056763
11Increased mean platelet volume (HP:0011877)2.78957584
12Flat acetabular roof (HP:0003180)2.78744794
13Thoracolumbar scoliosis (HP:0002944)2.76588444
14Mucopolysacchariduria (HP:0008155)2.76575337
15Urinary glycosaminoglycan excretion (HP:0003541)2.76575337
16IgM deficiency (HP:0002850)2.71505494
17Asymmetry of the thorax (HP:0001555)2.69983912
18Thoracic kyphosis (HP:0002942)2.69052591
19Thrombocytosis (HP:0001894)2.67976042
20Termporal pattern (HP:0011008)2.67250628
21Insidious onset (HP:0003587)2.67250628
22Follicular hyperkeratosis (HP:0007502)2.66318254
23Protrusio acetabuli (HP:0003179)2.64213178
24Abnormality of endocrine pancreas physiology (HP:0012093)2.61475178
25Abnormality of the pancreatic islet cells (HP:0006476)2.61475178
26Abnormality of oral frenula (HP:0000190)2.57181412
27Cellulitis (HP:0100658)2.56209550
28Dysostosis multiplex (HP:0000943)2.55524891
29Reduced antithrombin III activity (HP:0001976)2.54561087
30Hyperinsulinemic hypoglycemia (HP:0000825)2.54088277
31Vertebral compression fractures (HP:0002953)2.52520343
32Proximal tubulopathy (HP:0000114)2.51937862
33Back pain (HP:0003418)2.51016544
34Subacute progressive viral hepatitis (HP:0006572)2.50388072
35Ketoacidosis (HP:0001993)2.49657153
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46043657
37Xanthomatosis (HP:0000991)2.45548098
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44631387
39B lymphocytopenia (HP:0010976)2.43330538
40Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.42558681
41Spinal rigidity (HP:0003306)2.40561060
42Late onset (HP:0003584)2.39755164
43Symptomatic seizures (HP:0011145)2.38068237
44Abnormal foot bone ossification (HP:0010675)2.37457901
45Poor head control (HP:0002421)2.37091654
46Ankyloglossia (HP:0010296)2.36234576
47Abnormality of polysaccharide metabolism (HP:0011012)2.35314686
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35314686
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35314686
50Aortic dissection (HP:0002647)2.32210425
51Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.30335380
52Ketosis (HP:0001946)2.30192357
53Severe short stature (HP:0003510)2.29739173
54Small epiphyses (HP:0010585)2.29707100
55Deep venous thrombosis (HP:0002625)2.28931373
56Metaphyseal cupping (HP:0003021)2.28916192
57Hypobetalipoproteinemia (HP:0003563)2.28781501
58Vacuolated lymphocytes (HP:0001922)2.27395598
59Chronic diarrhea (HP:0002028)2.25970747
60Abnormality of the frontal sinuses (HP:0002687)2.25572147
61Syringomyelia (HP:0003396)2.24631075
62Spinal cord lesions (HP:0100561)2.24631075
63Hypoplasia of the thymus (HP:0000778)2.23432161
64Curly hair (HP:0002212)2.23386370
65Recurrent viral infections (HP:0004429)2.23061002
66Abnormal platelet volume (HP:0011876)2.22100006
67Hyperglycemia (HP:0003074)2.17874791
68Elbow flexion contracture (HP:0002987)2.17833453
69Abnormality of the acetabulum (HP:0003170)2.16596411
70Bladder diverticulum (HP:0000015)2.15664376
71Right ventricular cardiomyopathy (HP:0011663)2.14635226
72Recurrent bronchitis (HP:0002837)2.14634926
73Abnormality of the lumbar spine (HP:0100712)2.14284802
74Fatigue (HP:0012378)2.13223082
75Capillary hemangiomas (HP:0005306)2.12249879
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.10122749
77Generalized aminoaciduria (HP:0002909)2.09789779
78Spastic diplegia (HP:0001264)2.06795326
79Cutaneous melanoma (HP:0012056)2.06095034
80Cervical subluxation (HP:0003308)2.05380006
81Tetraparesis (HP:0002273)2.05165174
82Abnormality of dentin (HP:0010299)2.05155509
83Verrucae (HP:0200043)2.05002694
84Papilloma (HP:0012740)2.05002694
85Gastrointestinal inflammation (HP:0004386)2.04649516
86Mitral stenosis (HP:0001718)2.02946537
87Gout (HP:0001997)2.02759032
88Agammaglobulinemia (HP:0004432)2.02107579
89Deep philtrum (HP:0002002)2.01394897
90Intrahepatic cholestasis (HP:0001406)2.01336675
91Hepatocellular carcinoma (HP:0001402)2.00753800
92Relative macrocephaly (HP:0004482)2.00205881
93Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00134924
94Abnormal protein N-linked glycosylation (HP:0012347)2.00134924
95Abnormal protein glycosylation (HP:0012346)2.00134924
96Abnormal glycosylation (HP:0012345)2.00134924
97Impaired platelet aggregation (HP:0003540)1.99223147
98Abnormal platelet function (HP:0011869)1.99223147
99Abnormal tarsal ossification (HP:0008369)1.98919996
100Atrophic scars (HP:0001075)1.98791461
101Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.98268546
102Abnormality of T cell physiology (HP:0011840)1.96961143
103Myocardial infarction (HP:0001658)1.96083890
104Long toe (HP:0010511)1.95930460
105Global brain atrophy (HP:0002283)1.93918906
106Interstitial pulmonary disease (HP:0006530)1.93251768
107Aortic aneurysm (HP:0004942)1.92251580
108Hematochezia (HP:0002573)1.92063860
109Lower limb hyperreflexia (HP:0002395)1.91947006
110Soft skin (HP:0000977)1.91300573
111Micronodular cirrhosis (HP:0001413)1.90887803
112Protuberant abdomen (HP:0001538)1.90879983
113Inflammation of the large intestine (HP:0002037)1.90022559
114Viral hepatitis (HP:0006562)1.89687448
115Epiphyseal dysplasia (HP:0002656)1.88446029
116Coxa valga (HP:0002673)1.87471851
117Abnormality of the fingertips (HP:0001211)1.83420630
118Cardiovascular calcification (HP:0011915)1.83231690
119Abnormal cartilage morphology (HP:0002763)1.83167018
120Flattened epiphyses (HP:0003071)1.82578719
121Bilateral sensorineural hearing impairment (HP:0008619)1.82366386
122Redundant skin (HP:0001582)1.81680703
123Abnormality of purine metabolism (HP:0004352)1.81612170
124Cerebral aneurysm (HP:0004944)1.81051365
125Papilledema (HP:0001085)1.80891562
126Abnormality of the thoracic spine (HP:0100711)1.80582374
127Periodontitis (HP:0000704)1.80581888
128Menorrhagia (HP:0000132)1.80559281
129Abdominal distention (HP:0003270)1.80507892
130Complement deficiency (HP:0004431)1.80013756
131Entropion (HP:0000621)1.79292695
132Ulnar bowing (HP:0003031)1.79196300
133Ankle contracture (HP:0006466)1.78851177
134Resting tremor (HP:0002322)1.77514224
135Pancreatic islet-cell hyperplasia (HP:0004510)1.77438284
136Irregular vertebral endplates (HP:0003301)1.76699143
137Osteolytic defects of the hand bones (HP:0009699)1.76239802
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.76239802
139Nonimmune hydrops fetalis (HP:0001790)1.75777319
140Abnormality of B cell number (HP:0010975)1.75039742
141Gastrointestinal stroma tumor (HP:0100723)1.73818285
142Thin bony cortex (HP:0002753)1.73605394
143Eczematoid dermatitis (HP:0000976)1.73533146
144Selective tooth agenesis (HP:0001592)1.73390894
145Colitis (HP:0002583)1.72684768
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72611268
147Fat malabsorption (HP:0002630)1.72505670
148Hypoplasia of the pons (HP:0012110)1.72457834
149Deviation of the thumb (HP:0009603)1.72365062
150Chromsome breakage (HP:0040012)1.71969419
151Osteomyelitis (HP:0002754)1.71379768
152Abnormality of the pons (HP:0007361)1.71139323
153Deformed sella turcica (HP:0002681)1.70239403
154Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.69566695
155Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68968811
156Missing ribs (HP:0000921)1.68788643
157Abnormal umbilical cord blood vessels (HP:0011403)1.68721028
158Single umbilical artery (HP:0001195)1.68721028
159Abnormality of the fetal cardiovascular system (HP:0010948)1.68721028
160Insulin resistance (HP:0000855)1.68501779
161Abnormality of sulfur amino acid metabolism (HP:0004339)1.68350194
162Abnormality of the distal phalanges of the toes (HP:0010182)1.68005619
163Abnormality of the gastric mucosa (HP:0004295)1.67914598
164Abnormality of T cells (HP:0002843)1.67480124
165Abnormality of carpal bone ossification (HP:0006257)1.66613069
166Microvesicular hepatic steatosis (HP:0001414)1.66252347
167Abnormality of nucleobase metabolism (HP:0010932)1.65944000
168Lymphopenia (HP:0001888)1.65828688
169Coarse hair (HP:0002208)1.65198879
170Absent frontal sinuses (HP:0002688)1.65088187
171T lymphocytopenia (HP:0005403)1.64889564
172Abnormal biliary tract morphology (HP:0012440)1.64194549
173Hydroxyprolinuria (HP:0003080)1.63912491
174Abnormality of proline metabolism (HP:0010907)1.63912491
175Abnormal ossification of hand bones (HP:0005921)1.63443697
176Radial bowing (HP:0002986)1.62917909
177Recurrent gram-negative bacterial infections (HP:0005420)1.62577127
178Thyroid carcinoma (HP:0002890)1.62166969
179Self-mutilation (HP:0000742)1.62066393
180Hypolipoproteinemia (HP:0010981)1.61988108
181Aplasia cutis congenita (HP:0001057)1.61569979
182Ureteral duplication (HP:0000073)1.61166158
183Barrel-shaped chest (HP:0001552)1.60811179
184Hyperalaninemia (HP:0003348)1.59208108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.20964356
2TRIB33.52755639
3PKN23.31635181
4SCYL23.00859779
5MAP3K102.85239356
6EEF2K2.84500426
7PASK2.64996364
8FLT32.54651002
9PINK12.41926501
10MAP4K12.25303630
11MYLK2.08307931
12PBK2.03097727
13PTK61.97762639
14FRK1.91726335
15TAOK31.90472510
16EIF2AK31.86246299
17STK391.84145047
18LRRK21.76807154
19SIK11.74786750
20GRK61.71201232
21RIPK11.62275775
22NEK21.56897262
23IRAK31.49597461
24STK101.48794525
25BCKDK1.47592965
26RPS6KA41.46775308
27BTK1.46056363
28TRPM71.44408119
29BRSK21.42756776
30NME21.37014128
31CSNK1A1L1.31478865
32PDGFRA1.31076878
33SRPK11.31018643
34TYK21.29974643
35BRD41.27612532
36CDC71.27576348
37BMPR21.25139948
38MAP3K81.24626204
39JAK31.24243997
40LATS21.23550307
41STK38L1.23034758
42ZAP701.20894164
43DYRK31.17475044
44INSRR1.14160100
45FGFR41.12884001
46CLK11.12650463
47HIPK21.11970400
48ERBB31.11325613
49ILK1.09882844
50MAP3K121.08646492
51MAP2K31.08259504
52MAP3K141.08130429
53CSNK1G31.06972754
54CDK41.05831251
55CSNK1G11.05496995
56CSF1R1.04078005
57WNK41.02631208
58ARAF0.98272015
59LATS10.97263037
60MAP3K30.97108990
61KSR10.94270151
62CSK0.93779653
63MAPK110.92434711
64ICK0.92368150
65AKT30.91010505
66WEE10.90954163
67STK30.90491231
68MAP3K20.88790055
69JAK20.88499673
70RPS6KB20.85658641
71ITK0.84783843
72RPS6KB10.83859936
73MOS0.80379571
74BLK0.79055134
75DYRK1B0.78506143
76CDK80.76393484
77KIT0.76155314
78SYK0.74982697
79FER0.74274687
80JAK10.74210341
81CDK60.74146353
82LYN0.73850729
83MAP2K70.73580145
84MST1R0.69851594
85TLK10.69809244
86TEC0.67966372
87ZAK0.66929043
88PAK40.64905682
89RIPK40.64514384
90CDK70.63221898
91TBK10.63074904
92PDGFRB0.61856707
93MARK30.61603689
94ERBB40.61406433
95PIM10.61065086
96RPS6KA50.60158510
97LCK0.60104466
98BMX0.59093730
99NEK10.58775197
100AKT20.58333249
101CAMK1D0.57225125
102AURKB0.56521724
103MELK0.56056448
104FGFR30.55448757
105MET0.54771889
106MTOR0.54529953
107STK240.54140550
108BCR0.53659879
109PLK40.53340731
110NUAK10.51264573
111TTN0.51192133
112KDR0.51185344
113PIK3CG0.51068913
114MAP3K130.49925241
115CDK120.49883885
116MAP3K90.48813628
117ALK0.48635000
118ATR0.48224504
119TESK20.47881747
120PAK20.47829920
121CAMKK20.47706400
122MAP2K10.47649645
123TGFBR20.46481003
124KSR20.45768850
125NLK0.45722045
126STK40.44865964
127MAP2K20.43916764
128CHUK0.43790122
129CSNK1G20.43471052
130RAF10.43430278
131NEK90.43364110
132HCK0.42608209
133MAP3K50.41660078
134RET0.41601390
135SMG10.41297455
136EPHA20.40285250
137MAP3K10.40064617
138TGFBR10.40056362
139ATM0.38939494
140EIF2AK10.38803272
141CDK30.38555331
142NEK60.38219010
143MAPKAPK50.37648796
144MST40.37054154
145CAMK1G0.36553758
146MAPKAPK30.36100066
147TSSK60.35896895
148BRSK10.35128837
149TTK0.34200831
150ACVR1B0.33237640
151PIM20.32906904

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.82861785
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.66430457
3Selenocompound metabolism_Homo sapiens_hsa004502.56042690
4Protein export_Homo sapiens_hsa030602.42412045
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96270119
6One carbon pool by folate_Homo sapiens_hsa006701.95587216
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85521902
8Antigen processing and presentation_Homo sapiens_hsa046121.74669330
9N-Glycan biosynthesis_Homo sapiens_hsa005101.72083862
10ECM-receptor interaction_Homo sapiens_hsa045121.70625867
11Folate biosynthesis_Homo sapiens_hsa007901.68518133
12Nitrogen metabolism_Homo sapiens_hsa009101.62019077
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61696466
14Sulfur metabolism_Homo sapiens_hsa009201.58519654
15Sphingolipid metabolism_Homo sapiens_hsa006001.47899380
16B cell receptor signaling pathway_Homo sapiens_hsa046621.47690799
17Steroid biosynthesis_Homo sapiens_hsa001001.47381281
18Tryptophan metabolism_Homo sapiens_hsa003801.46603884
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.42973799
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.42945089
21Fatty acid degradation_Homo sapiens_hsa000711.40346361
22DNA replication_Homo sapiens_hsa030301.38926741
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35192283
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34731784
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.34645589
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32299003
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29110725
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.28049515
29Primary immunodeficiency_Homo sapiens_hsa053401.28049259
30Caffeine metabolism_Homo sapiens_hsa002321.26756620
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26050322
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24666357
33Renin-angiotensin system_Homo sapiens_hsa046141.24396638
34Nucleotide excision repair_Homo sapiens_hsa034201.23782704
35Other glycan degradation_Homo sapiens_hsa005111.23215664
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22708574
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21681222
38Lysine degradation_Homo sapiens_hsa003101.21341822
39Fat digestion and absorption_Homo sapiens_hsa049751.21133831
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20069927
41Complement and coagulation cascades_Homo sapiens_hsa046101.15829647
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.15776542
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13873178
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.13417855
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12453304
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11449831
47Systemic lupus erythematosus_Homo sapiens_hsa053221.10756686
48Lysosome_Homo sapiens_hsa041421.07357969
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07316492
50Starch and sucrose metabolism_Homo sapiens_hsa005001.06882350
51Legionellosis_Homo sapiens_hsa051341.06200209
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05472001
53Insulin resistance_Homo sapiens_hsa049311.03922007
54Pentose phosphate pathway_Homo sapiens_hsa000300.96919478
55ABC transporters_Homo sapiens_hsa020100.95936812
56Pyrimidine metabolism_Homo sapiens_hsa002400.95389896
57Focal adhesion_Homo sapiens_hsa045100.94466027
58Vitamin digestion and absorption_Homo sapiens_hsa049770.94238771
59Galactose metabolism_Homo sapiens_hsa000520.93277159
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.92948328
61Endometrial cancer_Homo sapiens_hsa052130.92466843
62Protein digestion and absorption_Homo sapiens_hsa049740.92056452
63Glutathione metabolism_Homo sapiens_hsa004800.91906525
64Arginine biosynthesis_Homo sapiens_hsa002200.90026630
65Chronic myeloid leukemia_Homo sapiens_hsa052200.87730835
66Leishmaniasis_Homo sapiens_hsa051400.87385096
67Viral carcinogenesis_Homo sapiens_hsa052030.86381460
68Fatty acid biosynthesis_Homo sapiens_hsa000610.84474785
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84418052
70TGF-beta signaling pathway_Homo sapiens_hsa043500.81364437
71Basal transcription factors_Homo sapiens_hsa030220.81129721
72Biosynthesis of amino acids_Homo sapiens_hsa012300.80545048
73Staphylococcus aureus infection_Homo sapiens_hsa051500.78066776
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76685466
75Small cell lung cancer_Homo sapiens_hsa052220.74852240
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74313346
77Osteoclast differentiation_Homo sapiens_hsa043800.72614480
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72255735
79Peroxisome_Homo sapiens_hsa041460.71811107
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.71756163
81mTOR signaling pathway_Homo sapiens_hsa041500.71157608
82Mismatch repair_Homo sapiens_hsa034300.70544809
83Thyroid cancer_Homo sapiens_hsa052160.68952609
84Phenylalanine metabolism_Homo sapiens_hsa003600.67538886
85Cell cycle_Homo sapiens_hsa041100.67036775
86Melanoma_Homo sapiens_hsa052180.63710616
87Measles_Homo sapiens_hsa051620.63381370
88Non-small cell lung cancer_Homo sapiens_hsa052230.63261464
89Fatty acid metabolism_Homo sapiens_hsa012120.63012108
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61912787
91Alcoholism_Homo sapiens_hsa050340.61889631
92Carbon metabolism_Homo sapiens_hsa012000.61679926
93Proteoglycans in cancer_Homo sapiens_hsa052050.61326871
94Sulfur relay system_Homo sapiens_hsa041220.60909607
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60501758
96Histidine metabolism_Homo sapiens_hsa003400.60396356
97Fructose and mannose metabolism_Homo sapiens_hsa000510.60011107
98Non-homologous end-joining_Homo sapiens_hsa034500.59678178
99Pancreatic cancer_Homo sapiens_hsa052120.59513361
100Hepatitis B_Homo sapiens_hsa051610.58973797
101PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57392009
102Pyruvate metabolism_Homo sapiens_hsa006200.57217655
103Adherens junction_Homo sapiens_hsa045200.57071076
104Fatty acid elongation_Homo sapiens_hsa000620.56858972
105Apoptosis_Homo sapiens_hsa042100.56645074
106Hematopoietic cell lineage_Homo sapiens_hsa046400.55903999
107Chemical carcinogenesis_Homo sapiens_hsa052040.55269983
108Bladder cancer_Homo sapiens_hsa052190.54932826
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.54925794
110Arginine and proline metabolism_Homo sapiens_hsa003300.54527371
111PPAR signaling pathway_Homo sapiens_hsa033200.54377721
112p53 signaling pathway_Homo sapiens_hsa041150.54308103
113beta-Alanine metabolism_Homo sapiens_hsa004100.53685166
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53184452
115Shigellosis_Homo sapiens_hsa051310.52511681
116Toxoplasmosis_Homo sapiens_hsa051450.52505983
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51316109
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51212978
119Base excision repair_Homo sapiens_hsa034100.51159442
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.50980139
121Bile secretion_Homo sapiens_hsa049760.50917791
122RNA transport_Homo sapiens_hsa030130.50816885
123Thyroid hormone synthesis_Homo sapiens_hsa049180.50707132
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49978630
125mRNA surveillance pathway_Homo sapiens_hsa030150.48607222
126Acute myeloid leukemia_Homo sapiens_hsa052210.48086233
127Tyrosine metabolism_Homo sapiens_hsa003500.46578451
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.45073005
129Fanconi anemia pathway_Homo sapiens_hsa034600.44887562
130Purine metabolism_Homo sapiens_hsa002300.44614647
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43638157
132Platelet activation_Homo sapiens_hsa046110.43497623
133Herpes simplex infection_Homo sapiens_hsa051680.43034958
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42655137
135Prostate cancer_Homo sapiens_hsa052150.41197951
136AMPK signaling pathway_Homo sapiens_hsa041520.40612099
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39162929
138Propanoate metabolism_Homo sapiens_hsa006400.39119690
139MicroRNAs in cancer_Homo sapiens_hsa052060.38723321

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