SLC30A6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.24613243
2nuclear pore organization (GO:0006999)5.67767168
3signal peptide processing (GO:0006465)5.64575625
4DNA deamination (GO:0045006)5.29712850
5proteasome assembly (GO:0043248)4.92563341
6L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.67838363
7protein deneddylation (GO:0000338)4.49687662
8pore complex assembly (GO:0046931)4.47988247
9cullin deneddylation (GO:0010388)4.39298174
10termination of RNA polymerase III transcription (GO:0006386)4.11742464
11transcription elongation from RNA polymerase III promoter (GO:0006385)4.11742464
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.07992222
13L-methionine salvage (GO:0071267)4.07416646
14L-methionine biosynthetic process (GO:0071265)4.07416646
15amino acid salvage (GO:0043102)4.07416646
16protein localization to kinetochore (GO:0034501)3.97792006
17regulation of centriole replication (GO:0046599)3.92472220
18mitotic sister chromatid cohesion (GO:0007064)3.90414028
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.90337692
20purine nucleobase biosynthetic process (GO:0009113)3.86365655
21ribosome assembly (GO:0042255)3.86220947
22positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82594319
23chromatin remodeling at centromere (GO:0031055)3.80482713
24protein localization to chromosome, centromeric region (GO:0071459)3.73638935
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.73561412
26antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.72635035
27negative regulation of ligase activity (GO:0051352)3.70985054
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.70985054
29nucleobase biosynthetic process (GO:0046112)3.68740375
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63331925
31DNA unwinding involved in DNA replication (GO:0006268)3.62707467
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.61035329
33DNA strand elongation involved in DNA replication (GO:0006271)3.58842934
34rRNA modification (GO:0000154)3.58755629
35telomere maintenance via semi-conservative replication (GO:0032201)3.57408857
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54966561
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54966561
38regulation of cellular amino acid metabolic process (GO:0006521)3.54463209
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.53992921
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.53883352
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.53883352
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.53883352
43establishment of integrated proviral latency (GO:0075713)3.48785410
447-methylguanosine mRNA capping (GO:0006370)3.47998040
45metaphase plate congression (GO:0051310)3.47652653
46mitotic sister chromatid segregation (GO:0000070)3.46861650
47regulation of centrosome cycle (GO:0046605)3.46579299
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45591674
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45591674
50DNA strand elongation (GO:0022616)3.42897552
51mitotic nuclear envelope disassembly (GO:0007077)3.42731117
52RNA capping (GO:0036260)3.42566943
537-methylguanosine RNA capping (GO:0009452)3.42566943
54termination of RNA polymerase I transcription (GO:0006363)3.40326113
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38078233
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.38078233
57sister chromatid segregation (GO:0000819)3.33573320
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.32872635
59transcription from RNA polymerase I promoter (GO:0006360)3.32008404
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30862944
61regulation of centrosome duplication (GO:0010824)3.28862795
62positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28678006
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27140662
64regulation of mitotic spindle checkpoint (GO:1903504)3.27140662
65antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.23032450
66positive regulation of ligase activity (GO:0051351)3.22686236
67methionine biosynthetic process (GO:0009086)3.21883250
68DNA replication-dependent nucleosome assembly (GO:0006335)3.20452185
69DNA replication-dependent nucleosome organization (GO:0034723)3.20452185
70nuclear envelope disassembly (GO:0051081)3.18965609
71membrane disassembly (GO:0030397)3.18965609
72ribosomal large subunit biogenesis (GO:0042273)3.17904603
73telomere maintenance via recombination (GO:0000722)3.17110943
74formation of translation preinitiation complex (GO:0001731)3.16773046
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14280654
76cotranslational protein targeting to membrane (GO:0006613)3.14180199
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.12382659
78transcription-coupled nucleotide-excision repair (GO:0006283)3.11808205
79IMP biosynthetic process (GO:0006188)3.11030927
80maturation of SSU-rRNA (GO:0030490)3.10595574
81protein neddylation (GO:0045116)3.08911331
82spindle checkpoint (GO:0031577)3.07531489
83protein targeting to ER (GO:0045047)3.06231937
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04973365
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04973365
86non-recombinational repair (GO:0000726)3.04848805
87double-strand break repair via nonhomologous end joining (GO:0006303)3.04848805
88cell cycle G1/S phase transition (GO:0044843)3.04468069
89G1/S transition of mitotic cell cycle (GO:0000082)3.04468069
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03809087
91mitochondrial respiratory chain complex I assembly (GO:0032981)3.03809087
92NADH dehydrogenase complex assembly (GO:0010257)3.03809087
93negative regulation of DNA repair (GO:0045738)3.03694920
94negative regulation of chromosome segregation (GO:0051985)3.03562531
95ribosomal small subunit assembly (GO:0000028)3.02392751
96rRNA methylation (GO:0031167)3.02173486
97protein localization to endoplasmic reticulum (GO:0070972)3.02134757
98pseudouridine synthesis (GO:0001522)3.01437094
99response to X-ray (GO:0010165)3.01127866
100negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00965303
101negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00965303
102negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00965303
103negative regulation of mitotic sister chromatid separation (GO:2000816)3.00965303
104negative regulation of sister chromatid segregation (GO:0033046)3.00965303
105DNA replication-independent nucleosome assembly (GO:0006336)2.99334527
106DNA replication-independent nucleosome organization (GO:0034724)2.99334527
107paraxial mesoderm development (GO:0048339)2.98874027
108mitotic spindle checkpoint (GO:0071174)2.97494181
109regulation of translational fidelity (GO:0006450)2.97334035
110regulation of mitochondrial translation (GO:0070129)2.96913586
111histone exchange (GO:0043486)2.96659425
112negative regulation of DNA-dependent DNA replication (GO:2000104)2.96345869
113transcription initiation from RNA polymerase I promoter (GO:0006361)2.96076580
114DNA replication checkpoint (GO:0000076)2.95326958
115tRNA aminoacylation for protein translation (GO:0006418)2.94625732
116regulation of chromosome segregation (GO:0051983)2.94043304
117translation (GO:0006412)2.93989995
118G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.93960986
119IMP metabolic process (GO:0046040)2.93934247
120GMP metabolic process (GO:0046037)2.93897616
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.92609220
122ribonucleoprotein complex biogenesis (GO:0022613)2.91352716
123tRNA aminoacylation (GO:0043039)2.91352692
124amino acid activation (GO:0043038)2.91352692
125mitotic chromosome condensation (GO:0007076)2.90950130
126nucleotide transmembrane transport (GO:1901679)2.90931826
127ribosomal small subunit biogenesis (GO:0042274)2.90688519
128folic acid-containing compound biosynthetic process (GO:0009396)2.89862827
129COPII vesicle coating (GO:0048208)2.89719980
130RNA-dependent DNA replication (GO:0006278)2.88882319
131regulation of sister chromatid segregation (GO:0033045)2.88114916
132regulation of mitotic sister chromatid separation (GO:0010965)2.88114916
133regulation of mitotic sister chromatid segregation (GO:0033047)2.88114916
134histone-serine phosphorylation (GO:0035404)2.87246729
135establishment of chromosome localization (GO:0051303)2.85965980
136DNA replication initiation (GO:0006270)2.85839262
137nucleotide-sugar biosynthetic process (GO:0009226)2.85807941
138ribosome biogenesis (GO:0042254)2.84539950
139establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83560903
140protein complex biogenesis (GO:0070271)2.82872465
141rRNA processing (GO:0006364)2.82416440
142regulation of ubiquitin-protein transferase activity (GO:0051438)2.81381339
143mitotic spindle assembly checkpoint (GO:0007094)2.81065283
144spindle assembly checkpoint (GO:0071173)2.80871029
145kinetochore organization (GO:0051383)2.80447831
146telomere maintenance via telomerase (GO:0007004)2.79893707
147mitotic metaphase plate congression (GO:0007080)2.79521394
148regulation of ligase activity (GO:0051340)2.78524963
149telomere maintenance via telomere lengthening (GO:0010833)2.76649736
150cellular component biogenesis (GO:0044085)2.76477730
151cellular protein complex localization (GO:0034629)2.76193586
152DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.74042715
153mitotic recombination (GO:0006312)2.74005989
154DNA strand renaturation (GO:0000733)2.73971132
155nucleotide-excision repair, DNA gap filling (GO:0006297)2.73848026
156positive regulation of cell cycle arrest (GO:0071158)2.71651089
157protein K6-linked ubiquitination (GO:0085020)2.71429080
158DNA geometric change (GO:0032392)2.71414586
159rRNA metabolic process (GO:0016072)2.71254810
160regulation of DNA endoreduplication (GO:0032875)2.71158115
161translational termination (GO:0006415)2.70846448
162mitochondrial respiratory chain complex assembly (GO:0033108)2.70420082
163L-serine metabolic process (GO:0006563)2.69833692
164dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.69748804
165neutrophil activation involved in immune response (GO:0002283)2.68879677
166CENP-A containing nucleosome assembly (GO:0034080)2.68309780
167replication fork processing (GO:0031297)2.67809426
168DNA duplex unwinding (GO:0032508)2.67411065
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.66640035
170positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66640035
171positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66640035
172DNA-templated transcription, elongation (GO:0006354)2.66573442
173guanosine-containing compound biosynthetic process (GO:1901070)2.66502974
174glutamine metabolic process (GO:0006541)2.66172627
175regulation of sister chromatid cohesion (GO:0007063)2.65347238
176transcription elongation from RNA polymerase II promoter (GO:0006368)2.64102058
177methionine metabolic process (GO:0006555)2.63722437
178mitotic G2/M transition checkpoint (GO:0044818)2.63612039
179regulation of helicase activity (GO:0051095)2.59115440
180tetrahydrofolate metabolic process (GO:0046653)2.59055881
181mitochondrial DNA replication (GO:0006264)2.58901003
182positive regulation of chromosome segregation (GO:0051984)2.58724242
183DNA double-strand break processing (GO:0000729)2.57226312
184pre-miRNA processing (GO:0031054)2.55475824
185regulation of spindle checkpoint (GO:0090231)2.55143400
186regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54811491
187regulation of spindle organization (GO:0090224)2.52587738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.68850903
2E2F7_22180533_ChIP-Seq_HELA_Human4.39502058
3* GABP_17652178_ChIP-ChIP_JURKAT_Human3.94404221
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.94290448
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80039984
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.78292670
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71973402
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.70570168
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38433812
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29946086
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.27638176
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.21115291
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90125070
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88117350
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80900630
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69305450
17* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68130228
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62467241
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61205452
20VDR_23849224_ChIP-Seq_CD4+_Human2.53541534
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48265024
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.47176820
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.44002208
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42596917
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34552927
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32407658
27* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25653175
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14163879
29DCP1A_22483619_ChIP-Seq_HELA_Human2.13465170
30ELK1_19687146_ChIP-ChIP_HELA_Human2.08390946
31FOXP3_21729870_ChIP-Seq_TREG_Human2.06723374
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03994857
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03476585
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.99191893
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.98980176
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97945743
37* XRN2_22483619_ChIP-Seq_HELA_Human1.97606862
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97405936
39* GABP_19822575_ChIP-Seq_HepG2_Human1.94253911
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89184866
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84428945
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82026920
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77358993
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76952648
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.70530883
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67454928
47* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64085625
48AR_21909140_ChIP-Seq_LNCAP_Human1.63998304
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.61712767
50* TTF2_22483619_ChIP-Seq_HELA_Human1.61170578
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61106893
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.59150551
53* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55145145
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50336203
55* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49709486
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47015598
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.46782861
58* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45558329
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.45188038
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41419891
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41121486
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.37216260
63* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36850677
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34510444
65FUS_26573619_Chip-Seq_HEK293_Human1.33770926
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.32061626
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30728502
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29280439
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28271651
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26196211
71* SPI1_23547873_ChIP-Seq_NB4_Human1.20351619
72EWS_26573619_Chip-Seq_HEK293_Human1.19655608
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19567703
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18518504
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17131936
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15804195
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.15421123
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11903664
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11885791
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11619149
81TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10737581
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09868258
83TFEB_21752829_ChIP-Seq_HELA_Human1.09241467
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07184019
85FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04592756
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03941843
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.02276114
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02231606
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01298433
90KDM5A_27292631_Chip-Seq_BREAST_Human1.01149336
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.00721878
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00262229
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00015981
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98520616
95BRD4_25478319_ChIP-Seq_HGPS_Human0.98295609
96* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97653811
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97480660
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97132431
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94962708
100IRF1_19129219_ChIP-ChIP_H3396_Human0.94872659
101HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94653508
102MYC_18940864_ChIP-ChIP_HL60_Human0.94169438
103WT1_19549856_ChIP-ChIP_CCG9911_Human0.93525016
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93483201
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.91864129
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91150530
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.90160638
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86918982
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86829867
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86294615
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86185872
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84830718
113* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82931112
114GATA1_22025678_ChIP-Seq_K562_Human0.82017060
115* ELF5_23300383_ChIP-Seq_T47D_Human0.81617255
116ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81404195
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80097101
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80097101
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79803698
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79774486
121PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79465078
122POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79116139
123MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79052048
124CHD1_26751641_Chip-Seq_LNCaP_Human0.78857527
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78092763
126GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77740852
127ZNF274_21170338_ChIP-Seq_K562_Hela0.77693723
128SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77282854
129GATA4_25053715_ChIP-Seq_YYC3_Human0.76631616
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75872026
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75632102
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.75035487
133* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74843378
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74599156
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.70402622
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69374119
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.68615567
138MYB_21317192_ChIP-Seq_ERMYB_Mouse0.68451668
139TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.68307114
140CIITA_25753668_ChIP-Seq_RAJI_Human0.68206470
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67877516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.18583114
2MP0003693_abnormal_embryo_hatching3.45932281
3MP0004957_abnormal_blastocyst_morpholog3.11132265
4MP0008007_abnormal_cellular_replicative2.76449120
5MP0003186_abnormal_redox_activity2.67422529
6MP0009333_abnormal_splenocyte_physiolog2.54015886
7MP0003890_abnormal_embryonic-extraembry2.52518765
8MP0006082_CNS_inflammation2.44210083
9MP0005671_abnormal_response_to2.34643363
10MP0010352_gastrointestinal_tract_polyps2.28991941
11MP0003724_increased_susceptibility_to2.21276739
12MP0002139_abnormal_hepatobiliary_system2.20797831
13MP0008932_abnormal_embryonic_tissue2.15388805
14MP0009697_abnormal_copulation2.14896426
15MP0004272_abnormal_basement_membrane2.13285521
16MP0008057_abnormal_DNA_replication2.12943724
17MP0008438_abnormal_cutaneous_collagen2.10483144
18MP0003950_abnormal_plasma_membrane2.08457818
19MP0009379_abnormal_foot_pigmentation2.02552077
20MP0005058_abnormal_lysosome_morphology1.99864614
21MP0003077_abnormal_cell_cycle1.98249836
22MP0001542_abnormal_bone_strength1.95881251
23MP0003656_abnormal_erythrocyte_physiolo1.89092092
24MP0001661_extended_life_span1.87955141
25MP0003111_abnormal_nucleus_morphology1.87036343
26MP0010094_abnormal_chromosome_stability1.85687566
27MP0009785_altered_susceptibility_to1.83991821
28MP0008058_abnormal_DNA_repair1.83541080
29MP0005451_abnormal_body_composition1.80795490
30MP0003567_abnormal_fetal_cardiomyocyte1.75230316
31MP0006054_spinal_hemorrhage1.73581194
32MP0002148_abnormal_hypersensitivity_rea1.61565423
33MP0002084_abnormal_developmental_patter1.58940501
34MP0001672_abnormal_embryogenesis/_devel1.58029087
35MP0005380_embryogenesis_phenotype1.58029087
36MP0001697_abnormal_embryo_size1.56415316
37MP0001764_abnormal_homeostasis1.53296492
38MP0001835_abnormal_antigen_presentation1.52644516
39MP0003984_embryonic_growth_retardation1.50479164
40MP0001853_heart_inflammation1.49856077
41MP0003195_calcinosis1.49612352
42MP0003718_maternal_effect1.49489075
43MP0002088_abnormal_embryonic_growth/wei1.46794109
44MP0000372_irregular_coat_pigmentation1.46633518
45MP0001293_anophthalmia1.46218295
46MP0003937_abnormal_limbs/digits/tail_de1.44196283
47MP0009384_cardiac_valve_regurgitation1.43548183
48MP0009840_abnormal_foam_cell1.41067187
49MP0002086_abnormal_extraembryonic_tissu1.40385542
50MP0003941_abnormal_skin_development1.38154107
51MP0010307_abnormal_tumor_latency1.34324226
52MP0003136_yellow_coat_color1.33536896
53MP0005084_abnormal_gallbladder_morpholo1.32602257
54MP0005085_abnormal_gallbladder_physiolo1.32535225
55MP0001286_abnormal_eye_development1.32437444
56MP0010030_abnormal_orbit_morphology1.31858117
57MP0002697_abnormal_eye_size1.31155081
58MP0002085_abnormal_embryonic_tissue1.30728959
59MP0002419_abnormal_innate_immunity1.30503176
60MP0002396_abnormal_hematopoietic_system1.26642158
61MP0005275_abnormal_skin_tensile1.26070131
62MP0008877_abnormal_DNA_methylation1.25382431
63MP0004264_abnormal_extraembryonic_tissu1.25163931
64MP0005408_hypopigmentation1.24406773
65MP0005000_abnormal_immune_tolerance1.24008471
66MP0000569_abnormal_digit_pigmentation1.21698984
67MP0005025_abnormal_response_to1.21634085
68MP0006036_abnormal_mitochondrial_physio1.21372059
69MP0002009_preneoplasia1.20927637
70MP0001243_abnormal_dermal_layer1.20311866
71MP0002080_prenatal_lethality1.17931877
72MP0005332_abnormal_amino_acid1.17253998
73MP0000647_abnormal_sebaceous_gland1.17174953
74MP0003191_abnormal_cellular_cholesterol1.15669669
75MP0000428_abnormal_craniofacial_morphol1.14847707
76MP0004197_abnormal_fetal_growth/weight/1.14104748
77MP0000689_abnormal_spleen_morphology1.13876538
78MP0001533_abnormal_skeleton_physiology1.10886137
79MP0010368_abnormal_lymphatic_system1.09894348
80MP0003943_abnormal_hepatobiliary_system1.09869154
81MP0004147_increased_porphyrin_level1.08346351
82MP0010678_abnormal_skin_adnexa1.08322924
83MP0002160_abnormal_reproductive_system1.07888280
84MP0002933_joint_inflammation1.07506740
85MP0003763_abnormal_thymus_physiology1.07474092
86MP0002723_abnormal_immune_serum1.07400020
87MP0002877_abnormal_melanocyte_morpholog1.06910541
88MP0004233_abnormal_muscle_weight1.05478615
89MP0002722_abnormal_immune_system1.05453062
90MP0008469_abnormal_protein_level1.04747077
91MP0002452_abnormal_antigen_presenting1.04737812
92MP0002420_abnormal_adaptive_immunity1.01514270
93MP0000383_abnormal_hair_follicle1.00919539
94MP0003786_premature_aging1.00428880
95MP0001915_intracranial_hemorrhage1.00316958
96MP0001819_abnormal_immune_cell0.99847232
97MP0003315_abnormal_perineum_morphology0.99633871
98MP0001845_abnormal_inflammatory_respons0.99565526
99MP0002060_abnormal_skin_morphology0.97483139
100MP0005636_abnormal_mineral_homeostasis0.95486110
101MP0002111_abnormal_tail_morphology0.95036038
102MP0002233_abnormal_nose_morphology0.94963652
103MP0002092_abnormal_eye_morphology0.94110231
104MP0009672_abnormal_birth_weight0.93960427
105MP0001800_abnormal_humoral_immune0.92668385
106MP0006035_abnormal_mitochondrial_morpho0.91679644
107MP0002163_abnormal_gland_morphology0.91657496
108MP0000427_abnormal_hair_cycle0.91271244
109MP0002429_abnormal_blood_cell0.90799678
110MP0002405_respiratory_system_inflammati0.90620991
111MP0000858_altered_metastatic_potential0.90550371
112MP0000313_abnormal_cell_death0.89888878
113MP0002132_abnormal_respiratory_system0.89866552
114MP0003436_decreased_susceptibility_to0.88615634
115MP0003705_abnormal_hypodermis_morpholog0.88524282
116MP0000537_abnormal_urethra_morphology0.88522979
117MP0003566_abnormal_cell_adhesion0.87564729
118MP0000716_abnormal_immune_system0.87272764
119MP0001666_abnormal_nutrient_absorption0.87236488
120MP0003942_abnormal_urinary_system0.87019317
121MP0009703_decreased_birth_body0.86935769
122MP0009765_abnormal_xenobiotic_induced0.86492657
123MP0000762_abnormal_tongue_morphology0.86461438
124MP0000432_abnormal_head_morphology0.84381276
125MP0005376_homeostasis/metabolism_phenot0.84056591
126MP0002398_abnormal_bone_marrow0.83880326
127MP0005464_abnormal_platelet_physiology0.83413150
128MP0009053_abnormal_anal_canal0.83129377
129MP0008260_abnormal_autophagy0.83102196
130MP0005319_abnormal_enzyme/_coenzyme0.82565509
131MP0001730_embryonic_growth_arrest0.81684359
132MP0010234_abnormal_vibrissa_follicle0.81670711
133MP0005390_skeleton_phenotype0.80729378
134MP0000579_abnormal_nail_morphology0.80497612
135MP0003011_delayed_dark_adaptation0.80276782
136MP0005023_abnormal_wound_healing0.80274785
137MP0000350_abnormal_cell_proliferation0.80103721
138MP0003828_pulmonary_edema0.79199270
139MP0005365_abnormal_bile_salt0.78622154
140MP0001986_abnormal_taste_sensitivity0.78488733
141MP0002019_abnormal_tumor_incidence0.78063736
142MP0000358_abnormal_cell_content/0.78055190
143MP0005360_urolithiasis0.77913671
144MP0003221_abnormal_cardiomyocyte_apopto0.77882633
145MP0005220_abnormal_exocrine_pancreas0.77004388
146MP0000685_abnormal_immune_system0.76891050
147MP0009763_increased_sensitivity_to0.76145531
148MP0003115_abnormal_respiratory_system0.75670178
149MP0003755_abnormal_palate_morphology0.75644926
150MP0004947_skin_inflammation0.74936052
151MP0001879_abnormal_lymphatic_vessel0.74896483
152MP0000343_altered_response_to0.74427052
153MP0002938_white_spotting0.73844637
154MP0003935_abnormal_craniofacial_develop0.73668816
155MP0003795_abnormal_bone_structure0.71932518
156MP0003252_abnormal_bile_duct0.71636672
157MP0005384_cellular_phenotype0.71325406
158MP0008873_increased_physiological_sensi0.71068800
159MP0005197_abnormal_uvea_morphology0.70967955
160MP0003119_abnormal_digestive_system0.70456191
161MP0001119_abnormal_female_reproductive0.67916933
162MP0001299_abnormal_eye_distance/0.67395209
163MP0005076_abnormal_cell_differentiation0.66459886
164MP0003868_abnormal_feces_composition0.66322368
165MP0005395_other_phenotype0.66126837
166MP0002254_reproductive_system_inflammat0.66121127
167MP0005083_abnormal_biliary_tract0.65314552
168MP0002109_abnormal_limb_morphology0.64648778
169MP0001216_abnormal_epidermal_layer0.63900477
170MP0005621_abnormal_cell_physiology0.62951929

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.06942864
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.95428402
3Abnormality of chromosome stability (HP:0003220)3.59007395
4Meckel diverticulum (HP:0002245)3.53906787
5Increased serum pyruvate (HP:0003542)3.49205677
6Abnormality of glycolysis (HP:0004366)3.49205677
7Type I transferrin isoform profile (HP:0003642)3.43796637
8Abnormality of the anterior horn cell (HP:0006802)3.39158484
9Degeneration of anterior horn cells (HP:0002398)3.39158484
10Abnormality of the ileum (HP:0001549)3.33403541
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.26094777
12Abnormality of the preputium (HP:0100587)3.24979892
13Nephroblastoma (Wilms tumor) (HP:0002667)3.23151488
143-Methylglutaconic aciduria (HP:0003535)3.20768768
15Embryonal renal neoplasm (HP:0011794)3.15630266
16Irregular epiphyses (HP:0010582)3.13257014
17Reduced antithrombin III activity (HP:0001976)3.02819355
18Sparse eyelashes (HP:0000653)2.99061062
19Abnormal protein glycosylation (HP:0012346)2.95843493
20Abnormal glycosylation (HP:0012345)2.95843493
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.95843493
22Abnormal protein N-linked glycosylation (HP:0012347)2.95843493
23Prolonged neonatal jaundice (HP:0006579)2.85871339
24Acute necrotizing encephalopathy (HP:0006965)2.82527045
25Pancreatic islet-cell hyperplasia (HP:0004510)2.81067617
26Cerebral hypomyelination (HP:0006808)2.80550727
27Rough bone trabeculation (HP:0100670)2.76655445
28Hepatocellular necrosis (HP:0001404)2.74179024
29Abnormal lung lobation (HP:0002101)2.71375253
30Hepatic necrosis (HP:0002605)2.67867011
31Parakeratosis (HP:0001036)2.66563789
32Duodenal stenosis (HP:0100867)2.65597239
33Small intestinal stenosis (HP:0012848)2.65597239
34Hypobetalipoproteinemia (HP:0003563)2.59192652
35Mitochondrial inheritance (HP:0001427)2.56602636
36Congenital ichthyosiform erythroderma (HP:0007431)2.54854641
37Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.53860919
38Petechiae (HP:0000967)2.53694596
39Megaloblastic anemia (HP:0001889)2.50049562
40Abnormality of the axillary hair (HP:0100134)2.47792682
41Abnormality of secondary sexual hair (HP:0009888)2.47792682
42Missing ribs (HP:0000921)2.47258813
43Abnormal mitochondria in muscle tissue (HP:0008316)2.46006036
44Amniotic constriction ring (HP:0009775)2.42818904
45Abnormality of placental membranes (HP:0011409)2.42818904
46Macrocytic anemia (HP:0001972)2.39679974
47Dry hair (HP:0011359)2.39637744
48Stomatitis (HP:0010280)2.39373379
49Tongue fasciculations (HP:0001308)2.39204775
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.38355456
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.38355456
52Abnormality of the umbilical cord (HP:0010881)2.36875380
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34650914
54Opisthotonus (HP:0002179)2.34378539
55Acute encephalopathy (HP:0006846)2.32838990
56Increased serum lactate (HP:0002151)2.31624267
57Hypoglycemic coma (HP:0001325)2.31532502
58Abnormal foot bone ossification (HP:0010675)2.31432471
59Hepatosplenomegaly (HP:0001433)2.28130523
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27576570
61Absent epiphyses (HP:0010577)2.27576570
62Increased CSF lactate (HP:0002490)2.27567052
63Birth length less than 3rd percentile (HP:0003561)2.27204867
64Recurrent abscess formation (HP:0002722)2.26991443
65Abnormality of the carotid arteries (HP:0005344)2.24748176
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22974158
67Congenital, generalized hypertrichosis (HP:0004540)2.22856031
68Microvesicular hepatic steatosis (HP:0001414)2.22549491
69Clubbing of toes (HP:0100760)2.19007321
70Selective tooth agenesis (HP:0001592)2.18166053
71Abnormality of the duodenum (HP:0002246)2.14999826
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.13779978
73Abnormal trabecular bone morphology (HP:0100671)2.13013282
74Entropion (HP:0000621)2.12437601
75Oral leukoplakia (HP:0002745)2.11908659
76Ependymoma (HP:0002888)2.11689256
77Absent radius (HP:0003974)2.11671045
78Hypoplastic labia majora (HP:0000059)2.11537430
79Ovarian neoplasm (HP:0100615)2.11074014
80Type 2 muscle fiber atrophy (HP:0003554)2.10998200
81Nausea (HP:0002018)2.10397756
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.09898878
83Patent foramen ovale (HP:0001655)2.09872753
84Flat capital femoral epiphysis (HP:0003370)2.08740099
85Microglossia (HP:0000171)2.07190231
86Stillbirth (HP:0003826)2.05409790
87Gonadal dysgenesis (HP:0000133)2.04778817
88Abnormal number of erythroid precursors (HP:0012131)2.03089255
89Progressive macrocephaly (HP:0004481)2.02497950
90Biliary tract neoplasm (HP:0100574)2.01555065
91Aplasia involving forearm bones (HP:0009822)2.01432648
92Absent forearm bone (HP:0003953)2.01432648
93Carpal bone hypoplasia (HP:0001498)2.01034650
94Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00470192
95Hypoplasia of the thymus (HP:0000778)2.00457992
96Vacuolated lymphocytes (HP:0001922)1.99878069
97Rhabdomyosarcoma (HP:0002859)1.99459777
98Methylmalonic aciduria (HP:0012120)1.98763952
99Elevated erythrocyte sedimentation rate (HP:0003565)1.98741156
100Abnormality of cells of the erythroid lineage (HP:0012130)1.98639346
101Abnormality of methionine metabolism (HP:0010901)1.97033040
102Premature rupture of membranes (HP:0001788)1.95834268
103Muscle fibrillation (HP:0010546)1.94227614
104Breast hypoplasia (HP:0003187)1.93725902
105Abnormality of serum amino acid levels (HP:0003112)1.93649696
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93236360
107Abnormal tarsal ossification (HP:0008369)1.92677509
108Cerebral edema (HP:0002181)1.90457854
109Duplicated collecting system (HP:0000081)1.89780752
11011 pairs of ribs (HP:0000878)1.89485222
111Reticulocytopenia (HP:0001896)1.88969093
112Severe combined immunodeficiency (HP:0004430)1.88873518
113Lactic acidosis (HP:0003128)1.88482731
114Dicarboxylic aciduria (HP:0003215)1.87717155
115Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87717155
116Absent eyebrow (HP:0002223)1.87117906
117Myelodysplasia (HP:0002863)1.86955772
118Abnormalities of placenta or umbilical cord (HP:0001194)1.86928273
119Right ventricular cardiomyopathy (HP:0011663)1.86740281
120Respiratory failure (HP:0002878)1.86701277
121Papillary thyroid carcinoma (HP:0002895)1.85160587
122Bifid tongue (HP:0010297)1.84926157
123Abnormality of the pancreatic islet cells (HP:0006476)1.84405288
124Abnormality of endocrine pancreas physiology (HP:0012093)1.84405288
125Curly hair (HP:0002212)1.84049434
126Microretrognathia (HP:0000308)1.83984356
127Abnormality of the labia majora (HP:0012881)1.83612154
128Poor head control (HP:0002421)1.83398657
129Small epiphyses (HP:0010585)1.83375095
130Abnormal biliary tract morphology (HP:0012440)1.82419416
131CNS demyelination (HP:0007305)1.82378028
132Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79520286
133Tetraparesis (HP:0002273)1.79304027
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78565896
135Syringomyelia (HP:0003396)1.78314471
136Spinal cord lesions (HP:0100561)1.78314471
137Lethargy (HP:0001254)1.78226916
138Sloping forehead (HP:0000340)1.77647538
139Female pseudohermaphroditism (HP:0010458)1.77536497
140Abnormality of the columella (HP:0009929)1.77000589
141Hypoglycemic seizures (HP:0002173)1.76379813
142CNS hypomyelination (HP:0003429)1.76274444
143Clitoromegaly (HP:0000057)1.75624152
144Abnormality of macrophages (HP:0004311)1.75333715
145Hyperglycinemia (HP:0002154)1.74005062
146Adrenal hypoplasia (HP:0000835)1.73019924
147Ureteral duplication (HP:0000073)1.71572309
148Hypoplastic pelvis (HP:0008839)1.71401655
149Epiphyseal stippling (HP:0010655)1.70893746
150Proximal tubulopathy (HP:0000114)1.70478344
151Abnormality of the fetal cardiovascular system (HP:0010948)1.70344776
152Abnormal umbilical cord blood vessels (HP:0011403)1.70344776
153Single umbilical artery (HP:0001195)1.70344776
154Ectopic kidney (HP:0000086)1.69712327
155Biconcave vertebral bodies (HP:0004586)1.69698992
156Delayed epiphyseal ossification (HP:0002663)1.69016574
157Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68979082
158Neoplasm of the colon (HP:0100273)1.65871236
159Beaking of vertebral bodies (HP:0004568)1.65623078
160Deviation of the thumb (HP:0009603)1.65194559
161Volvulus (HP:0002580)1.64215150
162Overlapping toe (HP:0001845)1.63883015
163Triphalangeal thumb (HP:0001199)1.63095882
164Colon cancer (HP:0003003)1.62627512
165Pterygium (HP:0001059)1.62370539
166Choanal atresia (HP:0000453)1.61803087
167Hyperinsulinemic hypoglycemia (HP:0000825)1.60854407
168Uterine neoplasm (HP:0010784)1.60199939
169Glioma (HP:0009733)1.59363423
170Neoplasm of the small intestine (HP:0100833)1.59240639
171Medulloblastoma (HP:0002885)1.58579344
172Deep philtrum (HP:0002002)1.57903912
173Short humerus (HP:0005792)1.57844582
174Aplasia/hypoplasia of the humerus (HP:0006507)1.57695180
175Abnormality of the pons (HP:0007361)1.57483855
176Neoplasm of the rectum (HP:0100743)1.56925491
177Osteolytic defects of the hand bones (HP:0009699)1.55810401
178Osteolytic defects of the phalanges of the hand (HP:0009771)1.55810401
179Ankyloglossia (HP:0010296)1.54742968
180Poikiloderma (HP:0001029)1.53723084
181Asymmetry of the thorax (HP:0001555)1.53322169
182Cortical dysplasia (HP:0002539)1.53089526
183Hypoplasia of the pons (HP:0012110)1.52934261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.01882043
2NME23.96454496
3EIF2AK13.27467865
4EIF2AK33.19123301
5WEE12.98850664
6STK162.85436447
7PDK22.45496370
8PBK2.37287864
9TRIM282.31384247
10NEK12.24424222
11SCYL22.18941214
12PIM22.14498716
13KDR2.05620174
14BRSK22.00004788
15VRK11.88067765
16LATS11.85908313
17MST41.82769170
18STK38L1.82656620
19BCKDK1.81649539
20NEK91.78071551
21TXK1.69814802
22SRPK11.61402518
23TESK21.60146445
24BRD41.59222212
25IRAK31.56780223
26CDK81.50159743
27ZAK1.43820385
28NME11.43056252
29TAF11.39968936
30PLK41.39363430
31TLK11.38273247
32TESK11.37619309
33ERBB31.36037763
34TSSK61.34592396
35NEK61.33702375
36STK31.32231232
37PAK41.28323585
38ERBB41.27242124
39LIMK11.26424585
40RPS6KA41.23344096
41KIT1.14108650
42ACVR1B1.13081555
43MAP3K121.11797942
44MKNK11.11357665
45NEK21.11191931
46IRAK41.08478097
47MAP3K31.08362115
48ARAF1.07021500
49SIK31.05676071
50CDC71.05449172
51MAP3K21.05304665
52FGFR11.02450148
53BMPR1B1.00160591
54ADRBK20.98218423
55EPHA20.97266970
56PLK30.94465392
57CCNB10.94371050
58EIF2AK20.92041731
59MELK0.91545589
60AURKA0.90879426
61YES10.90806307
62ZAP700.90779211
63PLK10.90358953
64DYRK30.88432223
65BRAF0.87138367
66AURKB0.85602342
67ATM0.85053204
68AKT30.84993718
69CDK70.84933513
70TBK10.83380973
71MET0.82745435
72BRSK10.82547559
73IKBKB0.82504352
74WNK30.81352149
75BLK0.80529885
76STK100.79127854
77CHEK10.76851923
78INSRR0.75010630
79BCR0.74794730
80TEC0.74039161
81MST1R0.72220783
82CDK60.71198211
83PASK0.68923248
84CSNK2A10.66798210
85MYLK0.65663304
86PDGFRA0.65234556
87CASK0.65210531
88KSR10.63779595
89FLT30.63422922
90MKNK20.63395838
91STK390.63096126
92CDK40.60393280
93MAP3K140.59434143
94LATS20.59260852
95CLK10.59135017
96MAP4K10.58102462
97RPS6KA50.56308228
98STK40.55805485
99GRK70.55552834
100LYN0.55294855
101CSNK2A20.55046785
102IKBKE0.54752812
103NLK0.54121275
104MAP3K100.53442217
105WNK40.52202909
106MAP3K80.51182081
107TRPM70.50516215
108ABL20.50250808
109RAF10.49593715
110TTK0.49049975
111MATK0.47109944
112DYRK20.46002704
113IRAK10.45181150
114PIM10.44686759
115MARK30.43366975
116STK240.42517651
117MAPK70.42470527
118OXSR10.42078206
119CDK10.40704404
120ATR0.40695854
121MAP3K110.40221454
122CHEK20.39991307
123CSNK1G10.39677014
124MAP2K20.37975566
125MAPK110.37680177
126NUAK10.37074124
127CDK120.36688627
128FER0.35760779
129PAK20.35186522
130GRK10.34689968
131PRKCI0.34339169
132FRK0.34180864
133PKN20.33976110
134TYK20.33829924
135PLK20.33228079
136RPS6KB20.33194167
137FGFR40.33083725
138TGFBR10.33058937
139PRKCD0.32649688
140VRK20.32645237
141CDK30.29534914
142PTK20.29376424
143PRKCE0.27983024
144PRKDC0.27332539
145CSNK1E0.26945717
146LMTK20.26756097
147ALK0.26034003

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.23645159
2Protein export_Homo sapiens_hsa030603.46717758
3RNA polymerase_Homo sapiens_hsa030203.42998653
4DNA replication_Homo sapiens_hsa030303.07726513
5Ribosome_Homo sapiens_hsa030102.95672473
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50987080
7Mismatch repair_Homo sapiens_hsa034302.45762206
8Nucleotide excision repair_Homo sapiens_hsa034202.27181260
9Pyrimidine metabolism_Homo sapiens_hsa002402.25965785
10Folate biosynthesis_Homo sapiens_hsa007902.09784219
11Homologous recombination_Homo sapiens_hsa034402.00541102
12Propanoate metabolism_Homo sapiens_hsa006401.82186041
13One carbon pool by folate_Homo sapiens_hsa006701.75781770
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73725745
15Basal transcription factors_Homo sapiens_hsa030221.73704931
16Steroid biosynthesis_Homo sapiens_hsa001001.72903137
17Oxidative phosphorylation_Homo sapiens_hsa001901.71483401
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.69259172
19Base excision repair_Homo sapiens_hsa034101.68341725
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64021235
21Spliceosome_Homo sapiens_hsa030401.60091892
22RNA transport_Homo sapiens_hsa030131.59474900
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53235436
24Vitamin B6 metabolism_Homo sapiens_hsa007501.52435408
25Sulfur relay system_Homo sapiens_hsa041221.50664836
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46293626
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43606993
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42642930
29Fatty acid elongation_Homo sapiens_hsa000621.39890704
30Sulfur metabolism_Homo sapiens_hsa009201.36299445
31Other glycan degradation_Homo sapiens_hsa005111.35051064
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31354900
33Vitamin digestion and absorption_Homo sapiens_hsa049771.30846404
34Parkinsons disease_Homo sapiens_hsa050121.26384016
35Glutathione metabolism_Homo sapiens_hsa004801.21281271
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.18080830
37Cell cycle_Homo sapiens_hsa041101.14694102
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.13038537
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12009455
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10482860
41Purine metabolism_Homo sapiens_hsa002301.10420562
42Thyroid cancer_Homo sapiens_hsa052161.03529984
43mRNA surveillance pathway_Homo sapiens_hsa030151.03454677
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02471325
45Fatty acid metabolism_Homo sapiens_hsa012121.02093105
46RNA degradation_Homo sapiens_hsa030180.97646112
47Small cell lung cancer_Homo sapiens_hsa052220.96950288
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95272156
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94951429
50Selenocompound metabolism_Homo sapiens_hsa004500.94542275
51Lysine degradation_Homo sapiens_hsa003100.93003732
52Arachidonic acid metabolism_Homo sapiens_hsa005900.92694544
53Sphingolipid metabolism_Homo sapiens_hsa006000.91882841
54Huntingtons disease_Homo sapiens_hsa050160.91866883
55Ether lipid metabolism_Homo sapiens_hsa005650.90869514
56Legionellosis_Homo sapiens_hsa051340.86210231
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85979998
58TGF-beta signaling pathway_Homo sapiens_hsa043500.84667680
59Histidine metabolism_Homo sapiens_hsa003400.84593180
60Adherens junction_Homo sapiens_hsa045200.84484495
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83669855
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82513983
63Butanoate metabolism_Homo sapiens_hsa006500.79139896
64Pentose phosphate pathway_Homo sapiens_hsa000300.79037809
65p53 signaling pathway_Homo sapiens_hsa041150.79010741
66Fatty acid degradation_Homo sapiens_hsa000710.79000880
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78935804
68Biosynthesis of amino acids_Homo sapiens_hsa012300.78436829
69Alzheimers disease_Homo sapiens_hsa050100.76252909
70Fatty acid biosynthesis_Homo sapiens_hsa000610.74701956
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74635929
72Metabolic pathways_Homo sapiens_hsa011000.74212850
73N-Glycan biosynthesis_Homo sapiens_hsa005100.73723613
74ECM-receptor interaction_Homo sapiens_hsa045120.73408544
75Fanconi anemia pathway_Homo sapiens_hsa034600.72262338
76Peroxisome_Homo sapiens_hsa041460.71502884
77Lysosome_Homo sapiens_hsa041420.71393365
78Caffeine metabolism_Homo sapiens_hsa002320.70512711
79Antigen processing and presentation_Homo sapiens_hsa046120.70255874
80Non-homologous end-joining_Homo sapiens_hsa034500.69775097
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69331918
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69213129
83Hippo signaling pathway_Homo sapiens_hsa043900.67560663
84Linoleic acid metabolism_Homo sapiens_hsa005910.66875734
85Epstein-Barr virus infection_Homo sapiens_hsa051690.65695374
86Chemical carcinogenesis_Homo sapiens_hsa052040.65676352
87Hematopoietic cell lineage_Homo sapiens_hsa046400.64740421
88Oocyte meiosis_Homo sapiens_hsa041140.63574434
89Fructose and mannose metabolism_Homo sapiens_hsa000510.63556877
90MicroRNAs in cancer_Homo sapiens_hsa052060.62375970
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62170683
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61856997
93Carbon metabolism_Homo sapiens_hsa012000.61691860
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59368792
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59032431
96Hedgehog signaling pathway_Homo sapiens_hsa043400.58228118
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57753991
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57132727
99Malaria_Homo sapiens_hsa051440.55179234
100Primary immunodeficiency_Homo sapiens_hsa053400.55159629
101Staphylococcus aureus infection_Homo sapiens_hsa051500.54857973
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.54200611
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53132664
104Basal cell carcinoma_Homo sapiens_hsa052170.53046967
105Prostate cancer_Homo sapiens_hsa052150.52021418
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50265926
107Pyruvate metabolism_Homo sapiens_hsa006200.49934359
108Proteoglycans in cancer_Homo sapiens_hsa052050.49556935
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.49472513
110Rheumatoid arthritis_Homo sapiens_hsa053230.47601769
111Fat digestion and absorption_Homo sapiens_hsa049750.47478882
112Galactose metabolism_Homo sapiens_hsa000520.47229462
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47139004
114Arginine and proline metabolism_Homo sapiens_hsa003300.46350682
115Vibrio cholerae infection_Homo sapiens_hsa051100.45811202
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.45166239
117Starch and sucrose metabolism_Homo sapiens_hsa005000.44599777
118Phagosome_Homo sapiens_hsa041450.43394820
119Viral carcinogenesis_Homo sapiens_hsa052030.41280723
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41264620
121Retinol metabolism_Homo sapiens_hsa008300.40818531
122Melanoma_Homo sapiens_hsa052180.40722739
123Tryptophan metabolism_Homo sapiens_hsa003800.39571285
124Renin-angiotensin system_Homo sapiens_hsa046140.38928599
125Asthma_Homo sapiens_hsa053100.38002388
126Allograft rejection_Homo sapiens_hsa053300.37464507
127Complement and coagulation cascades_Homo sapiens_hsa046100.37447996
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37080995
129Nitrogen metabolism_Homo sapiens_hsa009100.37005736
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35757674
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35438945
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35083028
133Bladder cancer_Homo sapiens_hsa052190.34472723
134Graft-versus-host disease_Homo sapiens_hsa053320.34335788
135Maturity onset diabetes of the young_Homo sapiens_hsa049500.33358061
136Wnt signaling pathway_Homo sapiens_hsa043100.32527231
137Collecting duct acid secretion_Homo sapiens_hsa049660.30767313
138beta-Alanine metabolism_Homo sapiens_hsa004100.27635594
139Pancreatic cancer_Homo sapiens_hsa052120.27060209

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