SLC30A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.42751542
2COPI coating of Golgi vesicle (GO:0048205)6.42751542
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.71923597
4positive regulation of gamma-delta T cell activation (GO:0046645)4.68243727
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.61881691
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.61881691
7response to pheromone (GO:0019236)4.56831058
8signal peptide processing (GO:0006465)4.50022249
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.47235675
10water-soluble vitamin biosynthetic process (GO:0042364)4.29722510
11regulation of glucokinase activity (GO:0033131)4.26637446
12regulation of hexokinase activity (GO:1903299)4.26637446
13lactate metabolic process (GO:0006089)4.25066352
14antigen processing and presentation of endogenous antigen (GO:0019883)4.17773334
15positive regulation of protein autophosphorylation (GO:0031954)4.12472593
16DNA double-strand break processing (GO:0000729)4.11396275
17COPII vesicle coating (GO:0048208)4.02512885
18keratinocyte development (GO:0003334)3.92285951
19platelet dense granule organization (GO:0060155)3.83260911
20protein retention in ER lumen (GO:0006621)3.82844537
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70552097
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.58100396
23DNA deamination (GO:0045006)3.56954409
24regulation of interferon-beta biosynthetic process (GO:0045357)3.44873616
25negative regulation of cell killing (GO:0031342)3.44221054
26negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44221054
27positive regulation of nuclease activity (GO:0032075)3.43531148
28regulation of gamma-delta T cell differentiation (GO:0045586)3.40958755
29replication fork processing (GO:0031297)3.40227325
30endoplasmic reticulum unfolded protein response (GO:0030968)3.38337607
31regulation of gamma-delta T cell activation (GO:0046643)3.38166099
32proteasome assembly (GO:0043248)3.34320078
33positive regulation of natural killer cell differentiation (GO:0032825)3.30250499
34cellular response to unfolded protein (GO:0034620)3.29360274
35UDP-N-acetylglucosamine metabolic process (GO:0006047)3.26397484
36synapsis (GO:0007129)3.21948600
37RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.20715325
38prostate gland growth (GO:0060736)3.19048252
39* sequestering of metal ion (GO:0051238)3.18563107
40regulation of nuclease activity (GO:0032069)3.17758575
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.15945560
42protein K6-linked ubiquitination (GO:0085020)3.14909385
43apoptotic cell clearance (GO:0043277)3.12797888
44exocrine pancreas development (GO:0031017)3.10932190
45ER-nucleus signaling pathway (GO:0006984)3.09992725
46regulation of DNA endoreduplication (GO:0032875)3.08929110
47antigen processing and presentation via MHC class Ib (GO:0002475)3.08664379
48negative regulation of axon extension involved in axon guidance (GO:0048843)3.08229232
49positive regulation by symbiont of host defense response (GO:0052509)3.07028167
50modulation by symbiont of host defense response (GO:0052031)3.07028167
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.07028167
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.07028167
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.07028167
54modulation by symbiont of host immune response (GO:0052553)3.07028167
55positive regulation of glycoprotein biosynthetic process (GO:0010560)3.04947145
56indolalkylamine metabolic process (GO:0006586)3.04814017
57tryptophan catabolic process (GO:0006569)3.04084901
58indole-containing compound catabolic process (GO:0042436)3.04084901
59indolalkylamine catabolic process (GO:0046218)3.04084901
60cellular response to topologically incorrect protein (GO:0035967)3.01870900
61kidney morphogenesis (GO:0060993)2.96224100
62limb bud formation (GO:0060174)2.95793778
63mannose metabolic process (GO:0006013)2.94057544
64dorsal/ventral axis specification (GO:0009950)2.94042033
65positive regulation of interferon-alpha production (GO:0032727)2.93064927
66somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92032056
67isotype switching (GO:0045190)2.92032056
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92032056
69protein prenylation (GO:0018342)2.90896613
70prenylation (GO:0097354)2.90896613
71L-fucose catabolic process (GO:0042355)2.89612468
72fucose catabolic process (GO:0019317)2.89612468
73L-fucose metabolic process (GO:0042354)2.89612468
74vesicle coating (GO:0006901)2.88900489
75dopamine transport (GO:0015872)2.88579371
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87689117
77protein N-linked glycosylation via asparagine (GO:0018279)2.86330705
78regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.86308270
79ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.85848891
80peptidyl-asparagine modification (GO:0018196)2.83944856
81respiratory chain complex IV assembly (GO:0008535)2.82966113
82nucleotide transmembrane transport (GO:1901679)2.82451092
83negative regulation of axon guidance (GO:1902668)2.82133794
84somite development (GO:0061053)2.81796538
85anterior/posterior axis specification, embryo (GO:0008595)2.81242745
86production of molecular mediator involved in inflammatory response (GO:0002532)2.81151810
87regulation of protein autophosphorylation (GO:0031952)2.80808813
88regulation of mesoderm development (GO:2000380)2.76412371
89regulation of interferon-alpha production (GO:0032647)2.76112930
90protein K11-linked deubiquitination (GO:0035871)2.74823869
91transepithelial transport (GO:0070633)2.74220302
92regulation of interleukin-12 biosynthetic process (GO:0045075)2.72853633
93response to endoplasmic reticulum stress (GO:0034976)2.72208510
94double-strand break repair via homologous recombination (GO:0000724)2.71731766
95recombinational repair (GO:0000725)2.71428325
96sulfation (GO:0051923)2.70926700
973-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.67981775
98purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.67981775
99cell adhesion mediated by integrin (GO:0033627)2.66726181
100cellular response to vitamin D (GO:0071305)2.65721291
101kynurenine metabolic process (GO:0070189)2.64941684
102branched-chain amino acid catabolic process (GO:0009083)2.61532489
103positive thymic T cell selection (GO:0045059)2.61026487
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60510398
105valine metabolic process (GO:0006573)2.60397051
106tryptophan metabolic process (GO:0006568)2.59228901
107negative regulation of neurological system process (GO:0031645)2.59156295
108protein N-linked glycosylation (GO:0006487)2.58199174
109positive regulation of glycolytic process (GO:0045821)2.56343030
110response to type I interferon (GO:0034340)2.56312559
111neural tube formation (GO:0001841)2.55882420
112peptide catabolic process (GO:0043171)2.54433013
113negative regulation of mast cell activation (GO:0033004)2.54292929
114female gonad development (GO:0008585)2.53404679
115cullin deneddylation (GO:0010388)2.51966807
116response to interferon-alpha (GO:0035455)2.51089227
117cellular response to type I interferon (GO:0071357)2.50384604
118type I interferon signaling pathway (GO:0060337)2.50384604
119positive regulation of isotype switching (GO:0045830)2.50151327
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.48977363
121cytochrome complex assembly (GO:0017004)2.48823511
122regulation of B cell receptor signaling pathway (GO:0050855)2.48371387
123embryonic foregut morphogenesis (GO:0048617)2.47989808
124pericardium development (GO:0060039)2.45146279
125dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.44689552
126cornea development in camera-type eye (GO:0061303)2.44468894
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.42914534
128neutrophil activation involved in immune response (GO:0002283)2.42824115
129preassembly of GPI anchor in ER membrane (GO:0016254)2.42543015
130regulation of acrosome reaction (GO:0060046)2.42478583
131endoderm formation (GO:0001706)2.41020816
132positive regulation of natural killer cell activation (GO:0032816)2.40823042
133regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.40686270
134estrogen metabolic process (GO:0008210)2.40497087
135cellular response to ATP (GO:0071318)2.39496495
136forebrain morphogenesis (GO:0048853)2.39227054
137establishment of protein localization to Golgi (GO:0072600)2.38984082
138positive regulation of interferon-beta production (GO:0032728)2.38639725
139cilium morphogenesis (GO:0060271)2.38264771
140regulation of natural killer cell differentiation (GO:0032823)2.38127178
141adenosine metabolic process (GO:0046085)2.38032501
142piRNA metabolic process (GO:0034587)2.37444047
143ketone body metabolic process (GO:1902224)2.37138516
144histone H2A acetylation (GO:0043968)2.36937645
145macrophage activation involved in immune response (GO:0002281)2.36718245
146anterograde synaptic vesicle transport (GO:0048490)2.36181916
147embryonic epithelial tube formation (GO:0001838)2.35345467
148S-adenosylmethionine metabolic process (GO:0046500)2.35056248
149negative chemotaxis (GO:0050919)2.35053939
150behavioral response to nicotine (GO:0035095)2.34726282
151negative regulation of systemic arterial blood pressure (GO:0003085)2.34286003
152positive regulation of glycoprotein metabolic process (GO:1903020)2.32817589
153multicellular organism reproduction (GO:0032504)2.32013795
154response to unfolded protein (GO:0006986)2.31631155
155I-kappaB phosphorylation (GO:0007252)2.30412114
156protein deneddylation (GO:0000338)2.30263892
157positive regulation of B cell differentiation (GO:0045579)2.29206334
158organ formation (GO:0048645)2.28846477
159GPI anchor metabolic process (GO:0006505)2.28826252
160protein polyglutamylation (GO:0018095)2.28581685
161parental behavior (GO:0060746)2.28057921
162protein targeting to Golgi (GO:0000042)2.27801599
163intraciliary transport (GO:0042073)2.27570292
164cellular response to vitamin (GO:0071295)2.27088268
165protein complex biogenesis (GO:0070271)2.27059224
166exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.27035109
167cobalamin metabolic process (GO:0009235)2.27022573
168regulation of natural killer cell activation (GO:0032814)2.25269203
169leukocyte aggregation (GO:0070486)2.24109348
170positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.23131971
171regulation of B cell differentiation (GO:0045577)2.22989549
172positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.22657484
173response to peptidoglycan (GO:0032494)2.22296907
174intestinal cholesterol absorption (GO:0030299)2.21920591
175detection of molecule of bacterial origin (GO:0032490)2.21805817
176response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20851024
177response to host immune response (GO:0052572)2.20851024
178growth hormone receptor signaling pathway (GO:0060396)2.17231056
179T-helper 1 type immune response (GO:0042088)2.16464958
180response to topologically incorrect protein (GO:0035966)2.14961435
181ER overload response (GO:0006983)2.14741987
182positive regulation of DNA recombination (GO:0045911)2.14028874
183positive regulation of humoral immune response (GO:0002922)2.12439605
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.12292840
185regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.11100458
186positive regulation of immunoglobulin mediated immune response (GO:0002891)2.11067620
187positive regulation of B cell mediated immunity (GO:0002714)2.11067620
188response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.11064584
189response to host (GO:0075136)2.11064584
190response to host defenses (GO:0052200)2.11064584
191endocrine pancreas development (GO:0031018)2.10047942
192positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.09586844
193gland morphogenesis (GO:0022612)2.09154014
194positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.09015580
195positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.04793779
196respiratory burst (GO:0045730)2.04792996
197hormone catabolic process (GO:0042447)2.04613112
198cellular response to interferon-alpha (GO:0035457)2.03852111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.24606915
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.38992558
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29727400
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23273873
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11305140
6GATA1_22025678_ChIP-Seq_K562_Human3.05903494
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.05805589
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.03971625
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98721063
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92237902
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.88330311
12ZNF274_21170338_ChIP-Seq_K562_Hela2.76195902
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75780164
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73213756
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67043040
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66801391
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.65921798
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56709081
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55822971
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.54533910
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53881214
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.48514131
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.44033797
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.42182030
25GBX2_23144817_ChIP-Seq_PC3_Human2.40011512
26FUS_26573619_Chip-Seq_HEK293_Human2.38999106
27VDR_22108803_ChIP-Seq_LS180_Human2.35691793
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30744434
29* EWS_26573619_Chip-Seq_HEK293_Human2.24785681
30P300_19829295_ChIP-Seq_ESCs_Human2.23769384
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.21627564
32MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20813939
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.12806775
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08924180
35PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06748979
36TAF15_26573619_Chip-Seq_HEK293_Human2.06031804
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05437442
38* GABP_17652178_ChIP-ChIP_JURKAT_Human2.04462460
39RXR_22158963_ChIP-Seq_LIVER_Mouse2.02594002
40* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01940596
41IGF1R_20145208_ChIP-Seq_DFB_Human2.01605358
42SMAD_19615063_ChIP-ChIP_OVARY_Human2.01305757
43PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00308670
44* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00209623
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97007574
46MYB_26560356_Chip-Seq_TH2_Human1.91669160
47CLOCK_20551151_ChIP-Seq_293T_Human1.85479371
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81960159
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81924534
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.80521854
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80405502
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.72258884
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.71468647
54SPI1_23547873_ChIP-Seq_NB4_Human1.69581074
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69100196
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68957247
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68669497
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67333426
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66967107
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66118071
61BCAT_22108803_ChIP-Seq_LS180_Human1.64534412
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63270644
63* GATA2_21666600_ChIP-Seq_HMVEC_Human1.61886961
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59286586
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58984317
66ER_23166858_ChIP-Seq_MCF-7_Human1.57655792
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.57626099
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.56998063
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55784633
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55759079
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.55672110
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55198671
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54969915
74SMAD4_21799915_ChIP-Seq_A2780_Human1.54251111
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54073114
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52937769
77* MYB_26560356_Chip-Seq_TH1_Human1.52794607
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52697321
79* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51433487
80MYC_22102868_ChIP-Seq_BL_Human1.51257548
81SCL_19346495_ChIP-Seq_HPC-7_Human1.50200004
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49589534
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49045469
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.48751857
85* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48637015
86RUNX_20019798_ChIP-Seq_JUKART_Human1.48042400
87SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47274121
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46199051
89CBP_20019798_ChIP-Seq_JUKART_Human1.46199051
90VDR_24763502_ChIP-Seq_THP-1_Human1.45574788
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45140642
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43517652
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42950268
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41977985
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41912273
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41389087
97STAT3_23295773_ChIP-Seq_U87_Human1.40750896
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.38946897
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.37181575
100E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37043908
101TRIM28_21343339_ChIP-Seq_HEK293_Human1.36920154
102NANOG_19829295_ChIP-Seq_ESCs_Human1.36027568
103SOX2_19829295_ChIP-Seq_ESCs_Human1.36027568
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35965022
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35366086
106* SOX2_20726797_ChIP-Seq_SW620_Human1.35200945
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34430580
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33963536
109CDX2_22108803_ChIP-Seq_LS180_Human1.33615279
110GATA4_25053715_ChIP-Seq_YYC3_Human1.33577008
111* MAF_26560356_Chip-Seq_TH1_Human1.33185972
112TFEB_21752829_ChIP-Seq_HELA_Human1.33004935
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32855953
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32829295
115* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32285672
116RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32142999
117AR_25329375_ChIP-Seq_VCAP_Human1.32003932
118TCF4_22108803_ChIP-Seq_LS180_Human1.31940425
119* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30866051
120* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30866051
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.29771105
122PU_27001747_Chip-Seq_BMDM_Mouse1.29452617
123GATA3_27048872_Chip-Seq_THYMUS_Human1.28976246
124FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26035186
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25991432
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25304750
127TCF4_23295773_ChIP-Seq_U87_Human1.25220331
128MYC_18940864_ChIP-ChIP_HL60_Human1.25066613
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24710500
130PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24588989
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23747986
132NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23594184
133P53_22387025_ChIP-Seq_ESCs_Mouse1.23463251
134FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22459013
135VDR_23849224_ChIP-Seq_CD4+_Human1.21796273
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20950396
137GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20599837
138SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.19685521
139E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19043175
140E2F1_18555785_Chip-Seq_ESCs_Mouse1.18915622
141* SMAD4_21741376_ChIP-Seq_EPCs_Human1.18669933
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18347441
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17112279
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17095767
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16747994
146* GATA6_25053715_ChIP-Seq_YYC3_Human1.16620135
147SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15976697
148P300_18555785_Chip-Seq_ESCs_Mouse1.15807039
149UTX_26944678_Chip-Seq_JUKART_Human1.15453150
150OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15017610
151SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14797086
152ESR1_21235772_ChIP-Seq_MCF-7_Human1.14515924
153CMYC_18555785_Chip-Seq_ESCs_Mouse1.14110527
154POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12701010
155STAT3_18555785_Chip-Seq_ESCs_Mouse1.12114981
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11160622
157GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11042467
158AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09684353
159CJUN_26792858_Chip-Seq_BT549_Human1.09662283
160FLI1_21867929_ChIP-Seq_TH2_Mouse1.09246378
161RUNX2_22187159_ChIP-Seq_PCA_Human1.08977104
162GATA3_26560356_Chip-Seq_TH2_Human1.07900066
163PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06826995
164CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06775622
165FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06728586
166TP53_22573176_ChIP-Seq_HFKS_Human1.06264687
167BP1_19119308_ChIP-ChIP_Hs578T_Human1.06214430
168TP53_18474530_ChIP-ChIP_U2OS_Human1.05986945
169FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05211058
170FOXA1_25329375_ChIP-Seq_VCAP_Human1.05211058
171TCF7_22412390_ChIP-Seq_EML_Mouse1.05136852
172CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04848961
173* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04288738
174HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04179735
175* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04006539
176SPI1_23127762_ChIP-Seq_K562_Human1.03913802
177* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03256061
178VDR_21846776_ChIP-Seq_THP-1_Human1.02577795
179BRD4_25478319_ChIP-Seq_HGPS_Human1.02402291
180CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00285043
181* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.00183152
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.99888423
183* ELK1_19687146_ChIP-ChIP_HELA_Human0.99690898
184HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99296994
185GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97562082
186NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96820660
187TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96740616
188GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95958595
189NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95167550
190NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95167550
191FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95144339
192PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93691363
193* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92616915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.75311238
2MP0000372_irregular_coat_pigmentation3.51238453
3MP0003300_gastrointestinal_ulcer2.66493274
4MP0008438_abnormal_cutaneous_collagen2.66346123
5MP0005367_renal/urinary_system_phenotyp2.62840111
6MP0000516_abnormal_urinary_system2.62840111
7MP0008877_abnormal_DNA_methylation2.46407634
8MP0001835_abnormal_antigen_presentation2.43172503
9MP0002837_dystrophic_cardiac_calcinosis2.40251371
10MP0000569_abnormal_digit_pigmentation2.40148564
11MP0002938_white_spotting2.25820477
12MP0003436_decreased_susceptibility_to2.22189853
13MP0005058_abnormal_lysosome_morphology2.15439247
14MP0002166_altered_tumor_susceptibility2.13144918
15MP0006054_spinal_hemorrhage2.10289089
16MP0003705_abnormal_hypodermis_morpholog2.10250836
17MP0002877_abnormal_melanocyte_morpholog2.02434140
18MP0003950_abnormal_plasma_membrane2.01728596
19MP0005220_abnormal_exocrine_pancreas1.96452468
20MP0005075_abnormal_melanosome_morpholog1.94408421
21MP0003890_abnormal_embryonic-extraembry1.92167528
22MP0003183_abnormal_peptide_metabolism1.87763700
23MP0005365_abnormal_bile_salt1.87585482
24MP0002876_abnormal_thyroid_physiology1.85445365
25MP0009785_altered_susceptibility_to1.83872039
26MP0006072_abnormal_retinal_apoptosis1.83743243
27MP0006292_abnormal_olfactory_placode1.80952098
28MP0000685_abnormal_immune_system1.78983071
29MP0005379_endocrine/exocrine_gland_phen1.77960083
30MP0004264_abnormal_extraembryonic_tissu1.77877847
31MP0002163_abnormal_gland_morphology1.77307362
32MP0003724_increased_susceptibility_to1.75989672
33MP0001485_abnormal_pinna_reflex1.74708269
34MP0005551_abnormal_eye_electrophysiolog1.74044996
35MP0002006_tumorigenesis1.70489971
36MP0005084_abnormal_gallbladder_morpholo1.68409089
37MP0005000_abnormal_immune_tolerance1.66533477
38MP0005275_abnormal_skin_tensile1.65128555
39MP0005253_abnormal_eye_physiology1.64372686
40MP0002419_abnormal_innate_immunity1.63115969
41MP0004947_skin_inflammation1.62140639
42MP0008872_abnormal_physiological_respon1.61705623
43MP0003252_abnormal_bile_duct1.61669239
44MP0005387_immune_system_phenotype1.60790738
45MP0001790_abnormal_immune_system1.60790738
46MP0006082_CNS_inflammation1.58571775
47MP0001533_abnormal_skeleton_physiology1.58427483
48MP0002160_abnormal_reproductive_system1.57200975
49MP0003283_abnormal_digestive_organ1.55398176
50MP0010352_gastrointestinal_tract_polyps1.54797160
51MP0005025_abnormal_response_to1.54691450
52MP0005174_abnormal_tail_pigmentation1.53367503
53MP0005671_abnormal_response_to1.52865315
54MP0000427_abnormal_hair_cycle1.52267515
55MP0002139_abnormal_hepatobiliary_system1.50937333
56MP0005646_abnormal_pituitary_gland1.48567431
57MP0003566_abnormal_cell_adhesion1.48345703
58MP0002090_abnormal_vision1.47634981
59MP0008058_abnormal_DNA_repair1.46756885
60MP0002148_abnormal_hypersensitivity_rea1.46711299
61MP0003786_premature_aging1.45575765
62MP0001984_abnormal_olfaction1.44181008
63MP0002693_abnormal_pancreas_physiology1.43752610
64MP0010155_abnormal_intestine_physiology1.42961725
65MP0002452_abnormal_antigen_presenting1.40016456
66MP0010234_abnormal_vibrissa_follicle1.39947731
67MP0003787_abnormal_imprinting1.37923876
68MP0001873_stomach_inflammation1.37559167
69MP0001800_abnormal_humoral_immune1.37326872
70MP0003718_maternal_effect1.36121883
71MP0002282_abnormal_trachea_morphology1.35927647
72MP0002751_abnormal_autonomic_nervous1.34453885
73MP0001845_abnormal_inflammatory_respons1.33865498
74MP0002723_abnormal_immune_serum1.33298749
75MP0001324_abnormal_eye_pigmentation1.32995390
76MP0003172_abnormal_lysosome_physiology1.31485575
77MP0002405_respiratory_system_inflammati1.30355502
78MP0005464_abnormal_platelet_physiology1.30314530
79MP0003303_peritoneal_inflammation1.30032158
80* MP0001666_abnormal_nutrient_absorption1.29291602
81MP0005389_reproductive_system_phenotype1.28251685
82MP0002060_abnormal_skin_morphology1.27722130
83MP0002998_abnormal_bone_remodeling1.27020145
84MP0005187_abnormal_penis_morphology1.26689861
85MP0003937_abnormal_limbs/digits/tail_de1.24667027
86MP0005171_absent_coat_pigmentation1.24279009
87MP0003646_muscle_fatigue1.23363591
88MP0003195_calcinosis1.22859935
89MP0001944_abnormal_pancreas_morphology1.22802103
90MP0001819_abnormal_immune_cell1.22024814
91MP0002420_abnormal_adaptive_immunity1.21568884
92MP0003763_abnormal_thymus_physiology1.20875351
93MP0008057_abnormal_DNA_replication1.20409257
94MP0003868_abnormal_feces_composition1.19824406
95MP0001293_anophthalmia1.18860703
96MP0000858_altered_metastatic_potential1.18484525
97MP0001986_abnormal_taste_sensitivity1.18023743
98MP0005023_abnormal_wound_healing1.17033071
99MP0004133_heterotaxia1.16813854
100MP0010678_abnormal_skin_adnexa1.16306834
101MP0010094_abnormal_chromosome_stability1.15283377
102MP0000465_gastrointestinal_hemorrhage1.14147359
103MP0008469_abnormal_protein_level1.13364043
104MP0005645_abnormal_hypothalamus_physiol1.12848853
105MP0005076_abnormal_cell_differentiation1.12564408
106MP0004215_abnormal_myocardial_fiber1.12457284
107MP0000647_abnormal_sebaceous_gland1.12335105
108MP0005257_abnormal_intraocular_pressure1.11284431
109MP0003011_delayed_dark_adaptation1.10304288
110MP0008995_early_reproductive_senescence1.10199147
111MP0005085_abnormal_gallbladder_physiolo1.09631475
112MP0004134_abnormal_chest_morphology1.06431696
113MP0000631_abnormal_neuroendocrine_gland1.05427720
114MP0000015_abnormal_ear_pigmentation1.03930274
115MP0002138_abnormal_hepatobiliary_system1.02771559
116MP0000383_abnormal_hair_follicle1.02667128
117MP0009764_decreased_sensitivity_to1.02468669
118MP0009697_abnormal_copulation1.02275963
119MP0005395_other_phenotype1.02046138
120MP0005360_urolithiasis1.01907954
121MP0001958_emphysema1.01520013
122MP0003795_abnormal_bone_structure1.00609929
123MP0002234_abnormal_pharynx_morphology1.00540284
124MP0009780_abnormal_chondrocyte_physiolo0.99885110
125MP0003806_abnormal_nucleotide_metabolis0.99382196
126MP0003045_fibrosis0.99284753
127MP0004885_abnormal_endolymph0.98358349
128MP0003866_abnormal_defecation0.97886835
129MP0001119_abnormal_female_reproductive0.97860506
130MP0004484_altered_response_of0.97664411
131MP0000609_abnormal_liver_physiology0.97480179
132MP0003448_altered_tumor_morphology0.97123115
133MP0010386_abnormal_urinary_bladder0.96970801
134MP0005390_skeleton_phenotype0.96863359
135MP0000371_diluted_coat_color0.96008917
136MP0002933_joint_inflammation0.94863524
137MP0002095_abnormal_skin_pigmentation0.94750973
138MP0009643_abnormal_urine_homeostasis0.93865401
139MP0005310_abnormal_salivary_gland0.93184250
140MP0000716_abnormal_immune_system0.92930464
141MP0002896_abnormal_bone_mineralization0.91394063
142MP0008875_abnormal_xenobiotic_pharmacok0.91274097
143MP0003943_abnormal_hepatobiliary_system0.91227557
144MP0003279_aneurysm0.91120251
145MP0000538_abnormal_urinary_bladder0.91001094
146MP0003121_genomic_imprinting0.90856051
147MP0004808_abnormal_hematopoietic_stem0.90601445
148MP0002398_abnormal_bone_marrow0.90070244
149MP0005408_hypopigmentation0.89876519
150MP0005332_abnormal_amino_acid0.88865269
151MP0002638_abnormal_pupillary_reflex0.88340051
152MP0001764_abnormal_homeostasis0.88074564
153MP0002295_abnormal_pulmonary_circulatio0.87586467
154MP0005083_abnormal_biliary_tract0.87476901
155MP0001881_abnormal_mammary_gland0.86864610
156MP0002396_abnormal_hematopoietic_system0.85023115
157MP0003091_abnormal_cell_migration0.84802176
158MP0003186_abnormal_redox_activity0.84647313
159MP0001853_heart_inflammation0.84000807
160MP0009278_abnormal_bone_marrow0.83067050
161MP0002928_abnormal_bile_duct0.82030451
162MP0003119_abnormal_digestive_system0.81863422
163MP0002168_other_aberrant_phenotype0.81632673
164MP0010368_abnormal_lymphatic_system0.80745965
165MP0000613_abnormal_salivary_gland0.80498784
166MP0002254_reproductive_system_inflammat0.80063891
167MP0000598_abnormal_liver_morphology0.79511711
168MP0002009_preneoplasia0.79380067
169MP0009333_abnormal_splenocyte_physiolog0.79280331
170MP0003191_abnormal_cellular_cholesterol0.78668084
171MP0000639_abnormal_adrenal_gland0.78461446
172MP0004782_abnormal_surfactant_physiolog0.78392880
173MP0001756_abnormal_urination0.78281332
174MP0000490_abnormal_crypts_of0.78182570
175MP0005195_abnormal_posterior_eye0.77733009
176MP0005410_abnormal_fertilization0.77654083
177MP0010307_abnormal_tumor_latency0.76373298
178MP0002277_abnormal_respiratory_mucosa0.75447512
179MP0001177_atelectasis0.73707213
180MP0002233_abnormal_nose_morphology0.73489742
181MP0000653_abnormal_sex_gland0.71676952
182MP0003941_abnormal_skin_development0.70471921
183MP0001929_abnormal_gametogenesis0.70263456
184MP0005391_vision/eye_phenotype0.70246372
185MP0008775_abnormal_heart_ventricle0.68831830
186MP0003567_abnormal_fetal_cardiomyocyte0.67509846

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.77057184
2Pancreatic fibrosis (HP:0100732)3.54490032
3Methylmalonic acidemia (HP:0002912)3.34178507
4Eczematoid dermatitis (HP:0000976)3.21414720
5True hermaphroditism (HP:0010459)3.20774213
6Abnormality of the intrinsic pathway (HP:0010989)3.17215626
7Vacuolated lymphocytes (HP:0001922)3.12481117
8Thrombocytosis (HP:0001894)3.05713834
9Thyroiditis (HP:0100646)3.00905697
10Abnormality of midbrain morphology (HP:0002418)3.00525251
11Molar tooth sign on MRI (HP:0002419)3.00525251
12Hypothermia (HP:0002045)2.98878652
13Hematochezia (HP:0002573)2.92990805
14Periodontitis (HP:0000704)2.89163555
15Intestinal atresia (HP:0011100)2.86516444
16Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86392473
17Recurrent abscess formation (HP:0002722)2.85046797
18T lymphocytopenia (HP:0005403)2.83362727
19Abnormality of the renal cortex (HP:0011035)2.79508314
20Recurrent bacterial skin infections (HP:0005406)2.77723399
21Abnormality of T cell number (HP:0011839)2.77469839
22Abnormality of methionine metabolism (HP:0010901)2.76800332
23Urinary glycosaminoglycan excretion (HP:0003541)2.70837252
24Mucopolysacchariduria (HP:0008155)2.70837252
25Abnormality of polysaccharide metabolism (HP:0011012)2.68841410
26Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68841410
27Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68841410
28Dysostosis multiplex (HP:0000943)2.67195140
29Abnormality of the common coagulation pathway (HP:0010990)2.67027842
30Cervical subluxation (HP:0003308)2.63625474
31Methylmalonic aciduria (HP:0012120)2.63613878
32Aortic dissection (HP:0002647)2.63606096
33Chronic hepatic failure (HP:0100626)2.62145366
34Abnormality of vitamin B metabolism (HP:0004340)2.61561016
35Hamartoma of the eye (HP:0010568)2.57838263
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.55199967
37Osteolytic defects of the hand bones (HP:0009699)2.55199967
38Protrusio acetabuli (HP:0003179)2.55090260
39Nephronophthisis (HP:0000090)2.53314126
40Hypoglycemic coma (HP:0001325)2.47643865
41Aortic aneurysm (HP:0004942)2.47576756
42Conjugated hyperbilirubinemia (HP:0002908)2.47294750
43Renal cortical cysts (HP:0000803)2.47220668
44Gaze-evoked nystagmus (HP:0000640)2.46161881
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.45780129
46Hypoglycemic seizures (HP:0002173)2.43559948
47Abolished electroretinogram (ERG) (HP:0000550)2.42160543
48Autoimmune thrombocytopenia (HP:0001973)2.41946426
49Hypoplastic pelvis (HP:0008839)2.41519097
50Elevated erythrocyte sedimentation rate (HP:0003565)2.40567124
51Congenital stationary night blindness (HP:0007642)2.39460750
52Abnormality of the renal medulla (HP:0100957)2.36767674
53Arterial thrombosis (HP:0004420)2.35897349
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.35223968
55Recurrent gram-negative bacterial infections (HP:0005420)2.35026237
56Pendular nystagmus (HP:0012043)2.33746507
57Abnormality of chromosome stability (HP:0003220)2.32753721
58Myositis (HP:0100614)2.31310056
59Increased cerebral lipofuscin (HP:0011813)2.30506482
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.30324418
61Hypoplasia of the fovea (HP:0007750)2.30324418
62Medial flaring of the eyebrow (HP:0010747)2.30282468
63Interstitial pulmonary disease (HP:0006530)2.29834786
64Recurrent viral infections (HP:0004429)2.29482266
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.29065110
66Furrowed tongue (HP:0000221)2.28170422
67Hypoproteinemia (HP:0003075)2.25785970
68Myocardial infarction (HP:0001658)2.25059006
69Meningioma (HP:0002858)2.23047256
70Aplasia/Hypoplasia of the tongue (HP:0010295)2.20910066
71Orchitis (HP:0100796)2.19628068
72Congenital, generalized hypertrichosis (HP:0004540)2.19498825
73Increased corneal curvature (HP:0100692)2.18161308
74Keratoconus (HP:0000563)2.18161308
75Nonimmune hydrops fetalis (HP:0001790)2.17183298
76Spondylolisthesis (HP:0003302)2.15601670
77Cystic liver disease (HP:0006706)2.14902803
78Symptomatic seizures (HP:0011145)2.14515180
79Short tibia (HP:0005736)2.14434691
80Generalized aminoaciduria (HP:0002909)2.14003890
81Pancreatic islet-cell hyperplasia (HP:0004510)2.12520438
82Conjunctival hamartoma (HP:0100780)2.12278254
83Recurrent fungal infections (HP:0002841)2.12212750
84Disproportionate short-trunk short stature (HP:0003521)2.12021808
85Peritonitis (HP:0002586)2.11922930
86Thoracolumbar scoliosis (HP:0002944)2.10408384
87Thin bony cortex (HP:0002753)2.08983912
88Long toe (HP:0010511)2.07322319
89Gingivitis (HP:0000230)2.06649022
90Gingival bleeding (HP:0000225)2.06581155
91Vertebral compression fractures (HP:0002953)2.05575687
92Premature rupture of membranes (HP:0001788)2.03987613
93Small hand (HP:0200055)2.03776420
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.03673726
95Reduced antithrombin III activity (HP:0001976)2.03611907
96Progressive inability to walk (HP:0002505)2.03022239
97Asplenia (HP:0001746)2.02520415
98Glioma (HP:0009733)2.01280672
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.00660731
100Abnormality of the fovea (HP:0000493)2.00634953
101Congenital sensorineural hearing impairment (HP:0008527)2.00361504
102Hypoplasia of the thymus (HP:0000778)2.00089342
103Neoplasm of the adrenal cortex (HP:0100641)2.00031485
104Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99573697
105Beaking of vertebral bodies (HP:0004568)1.99407280
106Ependymoma (HP:0002888)1.99105014
107Abnormality of macrophages (HP:0004311)1.98959714
108Aqueductal stenosis (HP:0002410)1.98952465
109Abdominal distention (HP:0003270)1.98911979
110Dilatation of the ascending aorta (HP:0005111)1.98443881
111Chorioretinal atrophy (HP:0000533)1.96560638
112Abnormality of the lumbar spine (HP:0100712)1.96471122
113Hyperglycemia (HP:0003074)1.96302881
114Posterior subcapsular cataract (HP:0007787)1.96197094
115Decreased central vision (HP:0007663)1.95577787
116Macroorchidism (HP:0000053)1.95550289
117Broad face (HP:0000283)1.95000185
118Severe short stature (HP:0003510)1.93836559
119Gonadotropin excess (HP:0000837)1.91066845
120Atrophic scars (HP:0001075)1.90956831
121Genital tract atresia (HP:0001827)1.90876972
122Bifid tongue (HP:0010297)1.90446326
123Attenuation of retinal blood vessels (HP:0007843)1.89056713
124Ketoacidosis (HP:0001993)1.88857866
125Tubular atrophy (HP:0000092)1.87656246
126Abnormal biliary tract physiology (HP:0012439)1.87564127
127Bile duct proliferation (HP:0001408)1.87564127
128Gastrointestinal infarctions (HP:0005244)1.86570596
129Aortic regurgitation (HP:0001659)1.85616744
130Abnormality of the astrocytes (HP:0100707)1.85145823
131Astrocytoma (HP:0009592)1.85145823
132Male pseudohermaphroditism (HP:0000037)1.84568763
133Chronic otitis media (HP:0000389)1.84181415
134Progressive macrocephaly (HP:0004481)1.84131574
135Congenital hepatic fibrosis (HP:0002612)1.83765043
136Fair hair (HP:0002286)1.83283288
137Abnormality of T cells (HP:0002843)1.82342993
138Abnormality of the nasal septum (HP:0000419)1.81692890
139Abnormality of the phalanges of the 5th finger (HP:0004213)1.80951337
140Cerebral aneurysm (HP:0004944)1.80692075
141Volvulus (HP:0002580)1.80484845
142Vasculitis (HP:0002633)1.79162614
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79051119
144Short 1st metacarpal (HP:0010034)1.79051119
145Abnormal rod and cone electroretinograms (HP:0008323)1.79046771
146Abnormality of serum amino acid levels (HP:0003112)1.77634175
147Vaginal atresia (HP:0000148)1.77627293
148Hyperinsulinemic hypoglycemia (HP:0000825)1.77365275
149Breast carcinoma (HP:0003002)1.76778226
150IgA deficiency (HP:0002720)1.76599850
151Rectal prolapse (HP:0002035)1.76496723
152Pustule (HP:0200039)1.76059067
153Recurrent skin infections (HP:0001581)1.75692916
154Aneurysm (HP:0002617)1.75666196
155Meckel diverticulum (HP:0002245)1.75662860
156Abnormal protein N-linked glycosylation (HP:0012347)1.75599881
157Abnormal protein glycosylation (HP:0012346)1.75599881
158Abnormal glycosylation (HP:0012345)1.75599881
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75599881
160Radial bowing (HP:0002986)1.75301161
161Stenosis of the external auditory canal (HP:0000402)1.75215093
162Prolonged partial thromboplastin time (HP:0003645)1.75123809
163Cutaneous melanoma (HP:0012056)1.74966926
164Spontaneous hematomas (HP:0007420)1.74928577
165Adrenal hypoplasia (HP:0000835)1.74735075
166Hypobetalipoproteinemia (HP:0003563)1.74076445
167Optic neuritis (HP:0100653)1.73708826
168Retrobulbar optic neuritis (HP:0100654)1.73708826
169Abnormality of the ileum (HP:0001549)1.71793409
170Abnormality of homocysteine metabolism (HP:0010919)1.70724361
171Homocystinuria (HP:0002156)1.70724361
172Subacute progressive viral hepatitis (HP:0006572)1.69979091
173Anencephaly (HP:0002323)1.69924189
174Hemoptysis (HP:0002105)1.69878391
175Abnormality of the duodenum (HP:0002246)1.69506847
176Fat malabsorption (HP:0002630)1.69495462
177Postaxial foot polydactyly (HP:0001830)1.69144660
178Menorrhagia (HP:0000132)1.68682361
179Hyperglycinemia (HP:0002154)1.68219715
180Ureteral obstruction (HP:0006000)1.68157277
181Abnormality of vitamin metabolism (HP:0100508)1.68154485
182Chronic diarrhea (HP:0002028)1.68078712
183Abnormality of the thoracic spine (HP:0100711)1.67098022
184Micronodular cirrhosis (HP:0001413)1.67064008
185Abnormality of B cell number (HP:0010975)1.67010643
186Short hallux (HP:0010109)1.66927019
187Gastrointestinal inflammation (HP:0004386)1.66513328
188Abnormality of glycolipid metabolism (HP:0010969)1.65880434
189Abnormality of liposaccharide metabolism (HP:0010968)1.65880434
190Abnormality of glycosphingolipid metabolism (HP:0004343)1.65880434
191Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65565025
192Mediastinal lymphadenopathy (HP:0100721)1.65441855
193Abnormality of endocrine pancreas physiology (HP:0012093)1.65070149
194Abnormality of the pancreatic islet cells (HP:0006476)1.65070149
195Abnormality of monocarboxylic acid metabolism (HP:0010996)1.64751848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.67092240
2TRIM284.39188898
3TAOK33.36225608
4BMPR1B2.98743543
5FRK2.83637337
6WNK32.55361928
7IRAK32.48212048
8JAK32.41528019
9PKN22.24495796
10TYK22.19778065
11MKNK22.15980848
12MAP3K142.15448641
13MAP4K22.14112272
14INSRR2.13182644
15GRK12.04416626
16TBK11.97195165
17TRIB31.96089065
18JAK11.95217765
19TNIK1.93680052
20MAP4K11.89538338
21BCR1.86982180
22FLT31.81484807
23SIK11.78694414
24BCKDK1.75176090
25ZAK1.70707626
26PTK61.68412826
27PLK21.68363609
28ADRBK21.66447643
29RPS6KA41.62336937
30IRAK41.61824004
31FGFR31.60139760
32FGFR41.58551340
33ZAP701.54227530
34PLK31.54047196
35EIF2AK11.53813637
36CSK1.47942963
37STK391.46733962
38PINK11.44926062
39CDK121.44182172
40FGFR21.43499846
41EPHA31.43010380
42LATS11.42916568
43IKBKE1.40061894
44PAK31.36050053
45WEE11.32279621
46TGFBR21.29819006
47MKNK11.27529046
48PASK1.24738451
49PDGFRA1.21560887
50NUAK11.20847665
51BTK1.20455677
52OXSR11.20148294
53NLK1.18513606
54NEK91.16534686
55ITK1.14760850
56TTN1.13516005
57KIT1.08971140
58TXK1.07233915
59LRRK21.06700835
60CHUK1.05325137
61PDK21.03487421
62TRPM71.01743349
63CSNK1G11.01301513
64PIK3CG1.00623814
65EPHB10.98668343
66MAPK130.96870158
67MAPKAPK30.95764798
68IKBKB0.95628731
69CSF1R0.95069947
70NME20.94694560
71MAP3K30.94099026
72STK38L0.94085755
73TEC0.93627057
74EIF2AK30.93025226
75TSSK60.92783767
76MAP3K40.92522976
77SCYL20.92363443
78PLK40.92274136
79ERBB30.90189300
80CASK0.89254283
81PTK20.88037240
82HIPK20.86213870
83CAMK1D0.84567699
84PDGFRB0.84061299
85MAP3K20.83769316
86PRKCE0.83750676
87BRD40.83313281
88STK100.82921561
89EIF2AK20.80420335
90MST1R0.79783292
91CSNK1G20.79709845
92EEF2K0.77006237
93IRAK10.75226742
94LCK0.74769480
95JAK20.74187195
96ADRBK10.73690089
97FER0.73593748
98HCK0.73036123
99CSNK1G30.71481327
100PAK40.71463483
101MAP3K120.70968284
102EPHA20.70947522
103TAOK20.70593448
104CSNK1A1L0.70411700
105PBK0.70043219
106TGFBR10.69588471
107MST40.66430047
108SIK30.66104025
109STK160.64887996
110AKT30.63400815
111VRK10.61823285
112PTK2B0.61656487
113STK30.61365857
114TIE10.60684916
115BUB10.60673099
116LYN0.59699633
117MAPK150.59556886
118SYK0.59360647
119MAP3K100.58615296
120RIPK10.57066483
121KDR0.56057411
122IGF1R0.55742467
123DDR20.54813266
124PLK10.53962640
125MUSK0.53341937
126MTOR0.51559256
127MARK30.51428286
128ERBB40.51126698
129RPS6KB20.50687925
130BLK0.50331834
131SRPK10.50013782
132CDK60.48525138
133NEK10.47956772
134FGFR10.47455367
135MET0.47080421
136BMX0.46751099
137PIK3CA0.46320467
138PAK20.45729641
139TESK10.45244109
140ACVR1B0.44766886
141CAMKK20.44599589
142TLK10.44165599
143BRSK20.43556594
144MAPKAPK20.43406295
145EGFR0.43070892
146PRKCG0.42781032
147WNK40.42780621
148DYRK1B0.41937507
149ATM0.40921994
150TAF10.40299760
151TNK20.39655099
152MAP2K30.38798757
153RPS6KA20.38584832
154PIM10.37517127
155PNCK0.37184123
156MELK0.36807034
157GRK70.36277680
158ABL10.35098125
159STK240.33205207
160VRK20.33186478
161BMPR20.32550825
162ATR0.32435244
163PRKCI0.31701095
164CSNK1A10.29711457
165CSNK1D0.28431264
166ROCK10.26964371
167GRK50.26382674
168PRKAA20.25901963
169EPHA40.25455697
170TTK0.24548516
171CAMK2A0.24404255
172PKN10.24090115
173BRSK10.22933836

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.58371454
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.47936681
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68556860
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.61432716
5Propanoate metabolism_Homo sapiens_hsa006402.48024247
6Non-homologous end-joining_Homo sapiens_hsa034502.42364670
7Proteasome_Homo sapiens_hsa030502.39580450
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37582098
9Homologous recombination_Homo sapiens_hsa034402.25713348
10N-Glycan biosynthesis_Homo sapiens_hsa005102.07216201
11Fanconi anemia pathway_Homo sapiens_hsa034601.96949090
12Selenocompound metabolism_Homo sapiens_hsa004501.96508555
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.96059115
14Caffeine metabolism_Homo sapiens_hsa002321.92113566
15Basal transcription factors_Homo sapiens_hsa030221.91071300
16Butanoate metabolism_Homo sapiens_hsa006501.90262111
17Leishmaniasis_Homo sapiens_hsa051401.87967875
18Other glycan degradation_Homo sapiens_hsa005111.84713810
19Lysosome_Homo sapiens_hsa041421.81756919
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81501542
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79411952
22RNA polymerase_Homo sapiens_hsa030201.78124368
23Sulfur metabolism_Homo sapiens_hsa009201.75663105
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75050612
25Antigen processing and presentation_Homo sapiens_hsa046121.72594077
26Phototransduction_Homo sapiens_hsa047441.71856599
27Legionellosis_Homo sapiens_hsa051341.67215567
28Nitrogen metabolism_Homo sapiens_hsa009101.63531751
29RNA degradation_Homo sapiens_hsa030181.58463780
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58146071
31Staphylococcus aureus infection_Homo sapiens_hsa051501.51519959
32Linoleic acid metabolism_Homo sapiens_hsa005911.51322372
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50905092
34Measles_Homo sapiens_hsa051621.49333912
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41488574
36Steroid biosynthesis_Homo sapiens_hsa001001.40296632
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.40027472
38Chemical carcinogenesis_Homo sapiens_hsa052041.38133995
39Osteoclast differentiation_Homo sapiens_hsa043801.36821325
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36363241
41Fatty acid elongation_Homo sapiens_hsa000621.33971737
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33189491
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31395508
44Malaria_Homo sapiens_hsa051441.30989944
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30948023
46Ether lipid metabolism_Homo sapiens_hsa005651.30005771
47Primary immunodeficiency_Homo sapiens_hsa053401.29329931
48TNF signaling pathway_Homo sapiens_hsa046681.29042278
49Retinol metabolism_Homo sapiens_hsa008301.28044972
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26977445
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.25554706
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24170530
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.24126821
54Toxoplasmosis_Homo sapiens_hsa051451.22925254
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21593139
56Vitamin digestion and absorption_Homo sapiens_hsa049771.19971180
57Hematopoietic cell lineage_Homo sapiens_hsa046401.17103361
58Influenza A_Homo sapiens_hsa051641.16068889
59Pertussis_Homo sapiens_hsa051331.14152206
60Regulation of autophagy_Homo sapiens_hsa041401.12103387
61Type I diabetes mellitus_Homo sapiens_hsa049401.09287304
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05716902
63Herpes simplex infection_Homo sapiens_hsa051681.04595894
64Complement and coagulation cascades_Homo sapiens_hsa046101.01913077
65Insulin resistance_Homo sapiens_hsa049311.01422206
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01154106
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00952482
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.98704390
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.97368037
70B cell receptor signaling pathway_Homo sapiens_hsa046620.97140489
71Apoptosis_Homo sapiens_hsa042100.96916263
72beta-Alanine metabolism_Homo sapiens_hsa004100.96389851
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96228250
74Hepatitis B_Homo sapiens_hsa051610.94400409
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93833839
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93830443
77Vitamin B6 metabolism_Homo sapiens_hsa007500.93174768
78Tuberculosis_Homo sapiens_hsa051520.93112070
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91972482
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90814814
81Graft-versus-host disease_Homo sapiens_hsa053320.90011175
82Renin-angiotensin system_Homo sapiens_hsa046140.89699339
83Glutathione metabolism_Homo sapiens_hsa004800.89678777
84ABC transporters_Homo sapiens_hsa020100.88809826
85p53 signaling pathway_Homo sapiens_hsa041150.88191781
86Small cell lung cancer_Homo sapiens_hsa052220.88106138
87Hepatitis C_Homo sapiens_hsa051600.87834142
88Adherens junction_Homo sapiens_hsa045200.87706328
89Starch and sucrose metabolism_Homo sapiens_hsa005000.87174387
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86139004
91Protein digestion and absorption_Homo sapiens_hsa049740.85932458
92Phagosome_Homo sapiens_hsa041450.85850553
93Allograft rejection_Homo sapiens_hsa053300.85342112
94Chronic myeloid leukemia_Homo sapiens_hsa052200.84979873
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84902623
96RNA transport_Homo sapiens_hsa030130.84856938
97Amoebiasis_Homo sapiens_hsa051460.82419019
98Oxidative phosphorylation_Homo sapiens_hsa001900.82342998
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82053775
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81719829
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81476036
102Shigellosis_Homo sapiens_hsa051310.81385022
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81128554
104Galactose metabolism_Homo sapiens_hsa000520.80020428
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.78384856
106Hedgehog signaling pathway_Homo sapiens_hsa043400.77675597
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.77098727
108TGF-beta signaling pathway_Homo sapiens_hsa043500.76700697
109Circadian rhythm_Homo sapiens_hsa047100.76506357
110One carbon pool by folate_Homo sapiens_hsa006700.76151983
111Folate biosynthesis_Homo sapiens_hsa007900.75782313
112Prolactin signaling pathway_Homo sapiens_hsa049170.75420094
113ECM-receptor interaction_Homo sapiens_hsa045120.73942475
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73914828
115Focal adhesion_Homo sapiens_hsa045100.73374823
116Fat digestion and absorption_Homo sapiens_hsa049750.72703462
117Mismatch repair_Homo sapiens_hsa034300.72588398
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71671294
119Tryptophan metabolism_Homo sapiens_hsa003800.71161134
120Prostate cancer_Homo sapiens_hsa052150.71058946
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70871434
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69874344
123Acute myeloid leukemia_Homo sapiens_hsa052210.66257501
124T cell receptor signaling pathway_Homo sapiens_hsa046600.66224121
125Viral myocarditis_Homo sapiens_hsa054160.65757273
126Purine metabolism_Homo sapiens_hsa002300.65436741
127Pancreatic cancer_Homo sapiens_hsa052120.63867290
128Sphingolipid metabolism_Homo sapiens_hsa006000.63529803
129Rheumatoid arthritis_Homo sapiens_hsa053230.62714515
130Lysine degradation_Homo sapiens_hsa003100.61729005
131Pyrimidine metabolism_Homo sapiens_hsa002400.61153619
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.60994986
133Metabolic pathways_Homo sapiens_hsa011000.60927411
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60760670
135Chemokine signaling pathway_Homo sapiens_hsa040620.59581471
136Proteoglycans in cancer_Homo sapiens_hsa052050.57364639
137Arachidonic acid metabolism_Homo sapiens_hsa005900.55918797
138Platelet activation_Homo sapiens_hsa046110.55439895
139Fatty acid metabolism_Homo sapiens_hsa012120.55212790
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54288811
141Glycerolipid metabolism_Homo sapiens_hsa005610.54263683
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52851502
143Nucleotide excision repair_Homo sapiens_hsa034200.52672569
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49778913
145Parkinsons disease_Homo sapiens_hsa050120.49334255
146Viral carcinogenesis_Homo sapiens_hsa052030.48762052
147Collecting duct acid secretion_Homo sapiens_hsa049660.48150570
148Type II diabetes mellitus_Homo sapiens_hsa049300.47348266
149Adipocytokine signaling pathway_Homo sapiens_hsa049200.47277966
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46293195
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45458815
152Peroxisome_Homo sapiens_hsa041460.45209384
153Fatty acid degradation_Homo sapiens_hsa000710.43557200
154Salmonella infection_Homo sapiens_hsa051320.42693567
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42463813
156Vibrio cholerae infection_Homo sapiens_hsa051100.41831012
157Dorso-ventral axis formation_Homo sapiens_hsa043200.41667264
158SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40565141
159Olfactory transduction_Homo sapiens_hsa047400.40212798
160Pyruvate metabolism_Homo sapiens_hsa006200.40031076
161Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39998774
162HTLV-I infection_Homo sapiens_hsa051660.39701375
163Basal cell carcinoma_Homo sapiens_hsa052170.39660108
164Ovarian steroidogenesis_Homo sapiens_hsa049130.38442172
165Melanoma_Homo sapiens_hsa052180.36543504
166Taste transduction_Homo sapiens_hsa047420.35788197
167Mineral absorption_Homo sapiens_hsa049780.35158471
168Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32969363
169Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30185872
170Oocyte meiosis_Homo sapiens_hsa041140.27905206
171Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27328253
172Hippo signaling pathway_Homo sapiens_hsa043900.27223302
173Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27131007

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