SLC30A8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine pancreas development (GO:0031018)7.75391226
2signal peptide processing (GO:0006465)7.32373210
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.31425541
4protein maturation by protein folding (GO:0022417)7.27494397
5COPII vesicle coating (GO:0048208)7.23094292
6peptide hormone processing (GO:0016486)7.12844585
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)7.06906814
8protein retention in ER lumen (GO:0006621)6.32086714
9regulation of type B pancreatic cell apoptotic process (GO:2000674)6.01140760
10regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022356.00751513
11glandular epithelial cell differentiation (GO:0002067)5.87128416
12cellular ketone body metabolic process (GO:0046950)5.55797740
13ER overload response (GO:0006983)5.26970425
14vesicle coating (GO:0006901)5.23796360
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.18624431
16positive regulation of nuclease activity (GO:0032075)4.93068629
17ketone body metabolic process (GO:1902224)4.91370350
18* positive regulation of insulin secretion (GO:0032024)4.90919571
19type B pancreatic cell development (GO:0003323)4.88451045
20* regulation of insulin secretion (GO:0050796)4.76979796
21glandular epithelial cell development (GO:0002068)4.76286361
22exocrine pancreas development (GO:0031017)4.75083479
23inositol phosphate catabolic process (GO:0071545)4.67363213
24negative regulation of glycoprotein biosynthetic process (GO:0010561)4.56426874
25regulation of nuclease activity (GO:0032069)4.51217316
26detection of calcium ion (GO:0005513)4.50201594
27negative regulation of hormone biosynthetic process (GO:0032353)4.49524110
28* insulin secretion (GO:0030073)4.44653197
29intra-Golgi vesicle-mediated transport (GO:0006891)4.44289844
30endoplasmic reticulum unfolded protein response (GO:0030968)4.38996139
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.36740323
32* regulation of peptide hormone secretion (GO:0090276)4.35973664
33cellular response to unfolded protein (GO:0034620)4.34670347
34phosphorylated carbohydrate dephosphorylation (GO:0046838)4.29901937
35inositol phosphate dephosphorylation (GO:0046855)4.29901937
36* regulation of peptide secretion (GO:0002791)4.27534796
37cellular response to topologically incorrect protein (GO:0035967)4.25406389
38glycerophospholipid catabolic process (GO:0046475)4.24403925
39negative regulation of insulin secretion (GO:0046676)4.15912833
40ER-nucleus signaling pathway (GO:0006984)4.13076157
41ER to Golgi vesicle-mediated transport (GO:0006888)4.03868067
42nitric oxide mediated signal transduction (GO:0007263)4.00288275
43toxin metabolic process (GO:0009404)3.96487990
44* positive regulation of peptide hormone secretion (GO:0090277)3.96192247
45regulation of glucokinase activity (GO:0033131)3.93491108
46regulation of hexokinase activity (GO:1903299)3.93491108
47columnar/cuboidal epithelial cell development (GO:0002066)3.91307678
48negative regulation of hormone metabolic process (GO:0032351)3.90580883
49protein N-linked glycosylation via asparagine (GO:0018279)3.90559166
50cellular response to vitamin D (GO:0071305)3.89742914
51peptidyl-asparagine modification (GO:0018196)3.87493147
52* regulation of hormone secretion (GO:0046883)3.82196563
53* positive regulation of peptide secretion (GO:0002793)3.81300724
54negative regulation of norepinephrine secretion (GO:0010700)3.80335009
55protein localization to Golgi apparatus (GO:0034067)3.72921240
56negative regulation of protein oligomerization (GO:0032460)3.71110787
57regulation of glucocorticoid secretion (GO:2000849)3.68658718
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.68431485
59water-soluble vitamin biosynthetic process (GO:0042364)3.64816027
60epithelial cell fate commitment (GO:0072148)3.63249431
61negative regulation of peptide hormone secretion (GO:0090278)3.62555251
62L-alpha-amino acid transmembrane transport (GO:1902475)3.62401949
63negative regulation of catecholamine secretion (GO:0033604)3.62226856
64response to endoplasmic reticulum stress (GO:0034976)3.60874744
65polyol catabolic process (GO:0046174)3.57036273
66protein N-linked glycosylation (GO:0006487)3.56886101
67negative regulation of execution phase of apoptosis (GO:1900118)3.56062991
68* regulation of peptide transport (GO:0090087)3.49824637
69negative regulation of peptide secretion (GO:0002792)3.49550911
70respiratory chain complex IV assembly (GO:0008535)3.48741591
71negative regulation of glycoprotein metabolic process (GO:1903019)3.46584857
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42061886
73response to unfolded protein (GO:0006986)3.40047427
74interleukin-1-mediated signaling pathway (GO:0070498)3.38333083
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.36914745
76purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.36914745
77astrocyte differentiation (GO:0048708)3.36768815
78GDP-mannose metabolic process (GO:0019673)3.35455124
79negative regulation of bone resorption (GO:0045779)3.34311869
80auditory receptor cell differentiation (GO:0042491)3.33518877
81response to topologically incorrect protein (GO:0035966)3.32167910
82negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.31508203
83cytochrome complex assembly (GO:0017004)3.30846671
84* peptide hormone secretion (GO:0030072)3.30393137
85Golgi organization (GO:0007030)3.26422133
86positive regulation of gluconeogenesis (GO:0045722)3.25505205
87regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.24350718
88* peptide secretion (GO:0002790)3.23341310
89* positive regulation of hormone secretion (GO:0046887)3.21605911
90protein autoprocessing (GO:0016540)3.20288893
91fatty acid homeostasis (GO:0055089)3.19249418
92lactate metabolic process (GO:0006089)3.16219034
93Golgi vesicle transport (GO:0048193)3.13671782
94negative regulation of gluconeogenesis (GO:0045721)3.13195890
95negative regulation of neurological system process (GO:0031645)3.11746956
96regulation of oxidative phosphorylation (GO:0002082)3.10945598
97regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)3.10496899
98macroautophagy (GO:0016236)3.09739312
99intestinal epithelial cell development (GO:0060576)3.08797321
100nitric oxide biosynthetic process (GO:0006809)3.07734374
101inner ear receptor cell development (GO:0060119)3.07163892
102positive regulation of response to extracellular stimulus (GO:0032106)3.06094318
103positive regulation of response to nutrient levels (GO:0032109)3.06094318
104cellular response to hepatocyte growth factor stimulus (GO:0035729)3.04690851
105response to hepatocyte growth factor (GO:0035728)3.04690851
106* response to hexose (GO:0009746)3.04602746
107positive regulation of macroautophagy (GO:0016239)3.02569997
108dendritic spine morphogenesis (GO:0060997)3.02349864
109peptide metabolic process (GO:0006518)3.02051222
110cellular response to glucagon stimulus (GO:0071377)2.98032887
111positive regulation of glycolytic process (GO:0045821)2.97222724
112signal transduction involved in regulation of gene expression (GO:0023019)2.96790028
113intraciliary transport (GO:0042073)2.96167112
114* response to glucose (GO:0009749)2.95457624
115regulation of corticosteroid hormone secretion (GO:2000846)2.90829496
116negative regulation of acute inflammatory response (GO:0002674)2.90668819
117dentate gyrus development (GO:0021542)2.90601477
118cardiac left ventricle morphogenesis (GO:0003214)2.89582428
119regulation of Golgi to plasma membrane protein transport (GO:0042996)2.89237007
120* response to monosaccharide (GO:0034284)2.88585875
121eosinophil chemotaxis (GO:0048245)2.88023062
122positive regulation of protein autophosphorylation (GO:0031954)2.86013619
123pharyngeal system development (GO:0060037)2.85899717
124negative regulation of JUN kinase activity (GO:0043508)2.85556340
125regulation of energy homeostasis (GO:2000505)2.85508562
126positive regulation of histone H3-K4 methylation (GO:0051571)2.84469748
127nucleoside diphosphate catabolic process (GO:0009134)2.84216313
128protein targeting to Golgi (GO:0000042)2.83379045
129positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.82807308
130positive regulation of calcium ion import (GO:0090280)2.82240956
131chemosensory behavior (GO:0007635)2.81917772
132* sequestering of metal ion (GO:0051238)2.81431362
133regulation of glucocorticoid metabolic process (GO:0031943)2.80907549
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75356026
135positive regulation of respiratory burst (GO:0060267)2.74147095
136nodal signaling pathway (GO:0038092)2.72418746
137positive regulation of glycogen biosynthetic process (GO:0045725)2.69314863
138L-phenylalanine catabolic process (GO:0006559)2.69197164
139erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69197164
140regulation of protein glycosylation (GO:0060049)2.69097558
141pteridine-containing compound biosynthetic process (GO:0042559)2.69000441
142regulation of calcium ion-dependent exocytosis (GO:0017158)2.67308772
143xenobiotic catabolic process (GO:0042178)2.61777472
144negative regulation of glycogen metabolic process (GO:0070874)2.60011562
145positive regulation of neurotransmitter transport (GO:0051590)2.59454952
146regulation of acrosome reaction (GO:0060046)2.59277041
147proline transport (GO:0015824)2.58108163
148phenylpropanoid metabolic process (GO:0009698)2.57960504
149calcium ion import (GO:0070509)2.56602573
150somite rostral/caudal axis specification (GO:0032525)2.56180398
151sphingomyelin metabolic process (GO:0006684)2.56179317
152succinate metabolic process (GO:0006105)2.55924108
153artery smooth muscle contraction (GO:0014824)2.55728616
154alanine transport (GO:0032328)2.55056641
155positive regulation of glucose metabolic process (GO:0010907)2.53541751
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.53498510
157L-phenylalanine metabolic process (GO:0006558)2.53498510
158regulation of steroid hormone biosynthetic process (GO:0090030)2.53496583
159axoneme assembly (GO:0035082)2.52856022
160kidney morphogenesis (GO:0060993)2.52825548
161* peptide transport (GO:0015833)2.51835613
162phospholipid dephosphorylation (GO:0046839)2.50085209
163neuromuscular process controlling posture (GO:0050884)2.50038405
164positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.49505463
165regulation of autophagic vacuole assembly (GO:2000785)2.48746116
166Golgi transport vesicle coating (GO:0048200)11.6335294
167COPI coating of Golgi vesicle (GO:0048205)11.6335294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PDX1_19855005_ChIP-ChIP_MIN6_Mouse4.53580216
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary4.37967301
3GATA1_22025678_ChIP-Seq_K562_Human3.70361680
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39742596
5* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26323089
6PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.19357110
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.01664890
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01422958
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.0835399
10CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92062375
11ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86170671
12* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.80520865
13P300_19829295_ChIP-Seq_ESCs_Human1.78433040
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77792868
15SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76828446
16HTT_18923047_ChIP-ChIP_STHdh_Human1.75750040
17IGF1R_20145208_ChIP-Seq_DFB_Human1.75620286
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.75570058
19FUS_26573619_Chip-Seq_HEK293_Human1.75284886
20* SMAD4_21799915_ChIP-Seq_A2780_Human1.73657264
21FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.72880329
22REST_19997604_ChIP-ChIP_NEURONS_Mouse1.69948736
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69543683
24NR3C1_23031785_ChIP-Seq_PC12_Mouse1.67768352
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67094955
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66405442
27TAF15_26573619_Chip-Seq_HEK293_Human1.64725080
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64104766
29BCAT_22108803_ChIP-Seq_LS180_Human1.60131399
30SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.59706460
31OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.59403738
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59032364
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57114156
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56882538
35TFEB_21752829_ChIP-Seq_HELA_Human1.55837213
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.55654719
37REST_21632747_ChIP-Seq_MESCs_Mouse1.54700995
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52907814
39* AR_25329375_ChIP-Seq_VCAP_Human1.52578356
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50080691
41VDR_22108803_ChIP-Seq_LS180_Human1.49040315
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47332894
43ER_23166858_ChIP-Seq_MCF-7_Human1.45842912
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.45743207
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43359799
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41551795
47ZNF274_21170338_ChIP-Seq_K562_Hela1.40685534
48FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39164554
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38948422
50AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36845695
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.35654038
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.35338629
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.34865876
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34798853
55P53_22387025_ChIP-Seq_ESCs_Mouse1.34754449
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.33509946
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31253617
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30601303
59CBP_20019798_ChIP-Seq_JUKART_Human1.30601303
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29614253
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29286833
62EWS_26573619_Chip-Seq_HEK293_Human1.28882274
63CDX2_22108803_ChIP-Seq_LS180_Human1.27878181
64REST_18959480_ChIP-ChIP_MESCs_Mouse1.27081477
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.26631191
66FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.26512733
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24589956
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24266373
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23603259
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21728550
71NANOG_19829295_ChIP-Seq_ESCs_Human1.21110596
72SOX2_19829295_ChIP-Seq_ESCs_Human1.21110596
73SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20438316
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.20402817
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19925958
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18817327
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.18251031
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18106658
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.16136254
80EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15972850
81TCF4_22108803_ChIP-Seq_LS180_Human1.15830347
82STAT3_23295773_ChIP-Seq_U87_Human1.15624489
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14531142
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14252236
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13278794
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13129353
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12845841
88TP53_22573176_ChIP-Seq_HFKS_Human1.11145225
89ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11141819
90P300_18555785_Chip-Seq_ESCs_Mouse1.10657213
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.10626386
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.09946994
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09860492
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.09802909
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09350633
96RUNX2_22187159_ChIP-Seq_PCA_Human1.09182133
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09018179
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08561657
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07747913
100* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07689594
101* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07689584
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07473201
103FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07247230
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.06010134
105GATA1_19941826_ChIP-Seq_K562_Human1.04348823
106* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04299894
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.04216179
108PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03002088
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02855793
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02133350
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01865675
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01604894
113* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01282999
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00310083
115* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00177366
116OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99878510
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.99453122
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.98516538
119TBL1_22424771_ChIP-Seq_293T_Human0.98112158
120* TAL1_26923725_Chip-Seq_HPCs_Mouse0.97932794
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97906752
122FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96336313
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.95582142
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95497355
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95038526
126EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94327814
127FLI1_21867929_ChIP-Seq_TH2_Mouse0.93943225
128* ERG_20517297_ChIP-Seq_VCAP_Human0.92868002
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.89133320
130GF1B_26923725_Chip-Seq_HPCs_Mouse0.87284815
131SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87115529
132GBX2_23144817_ChIP-Seq_PC3_Human0.86716429
133STAT3_18555785_Chip-Seq_ESCs_Mouse0.86663752
134GATA3_27048872_Chip-Seq_THYMUS_Human0.85705824
135* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84315997
136* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82658295
137GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82421379
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81707861
139NANOG_18555785_Chip-Seq_ESCs_Mouse0.80878630
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80837201
141NMYC_18555785_Chip-Seq_ESCs_Mouse0.80641428
142SOX2_20726797_ChIP-Seq_SW620_Human0.80508014
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79843883
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79766632
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.79532723
146YAP1_20516196_ChIP-Seq_MESCs_Mouse0.79394137
147* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79144590
148HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78984972
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78539904
150TDRD3_21172665_ChIP-Seq_MCF-7_Human0.78488555
151IRF8_22096565_ChIP-ChIP_GC-B_Human0.78284042
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78148400
153GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77244140
154SMAD3_21741376_ChIP-Seq_ESCs_Human0.76856001
155* AR_20517297_ChIP-Seq_VCAP_Human0.76477033
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76468464
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.76397870
158NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75121639
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.74033587
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73791944
161CHD1_26751641_Chip-Seq_LNCaP_Human0.73533023
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.73334594
163TCF4_23295773_ChIP-Seq_U87_Human0.73080256
164* FOXA1_25329375_ChIP-Seq_VCAP_Human0.72875513
165* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.72875513
166* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.72684750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog5.72691715
2MP0004043_abnormal_pH_regulation4.62658859
3MP0003283_abnormal_digestive_organ4.59434925
4MP0000013_abnormal_adipose_tissue4.14531315
5* MP0002693_abnormal_pancreas_physiology4.12862604
6MP0009780_abnormal_chondrocyte_physiolo4.08183991
7MP0003195_calcinosis3.97386285
8MP0001944_abnormal_pancreas_morphology3.95724985
9MP0005379_endocrine/exocrine_gland_phen3.83004733
10MP0010386_abnormal_urinary_bladder3.80326827
11MP0003183_abnormal_peptide_metabolism3.74384341
12MP0002909_abnormal_adrenal_gland3.73007829
13MP0000678_abnormal_parathyroid_gland3.62067075
14MP0010234_abnormal_vibrissa_follicle3.54119415
15MP0002837_dystrophic_cardiac_calcinosis2.99634547
16MP0005220_abnormal_exocrine_pancreas2.89406831
17MP0006072_abnormal_retinal_apoptosis2.53708277
18MP0008877_abnormal_DNA_methylation2.47873203
19* MP0002078_abnormal_glucose_homeostasis2.34266715
20MP0005646_abnormal_pituitary_gland2.27023290
21MP0000003_abnormal_adipose_tissue2.21210903
22MP0001986_abnormal_taste_sensitivity2.05602823
23MP0005645_abnormal_hypothalamus_physiol1.96732930
24MP0002638_abnormal_pupillary_reflex1.82862579
25MP0004264_abnormal_extraembryonic_tissu1.82071602
26MP0009046_muscle_twitch1.77606891
27MP0002254_reproductive_system_inflammat1.74995703
28MP0003122_maternal_imprinting1.66014394
29MP0003123_paternal_imprinting1.61950702
30MP0001765_abnormal_ion_homeostasis1.60358958
31MP0002928_abnormal_bile_duct1.59969163
32MP0010329_abnormal_lipoprotein_level1.54403559
33MP0002163_abnormal_gland_morphology1.53110398
34MP0003121_genomic_imprinting1.53081286
35MP0000462_abnormal_digestive_system1.51520661
36MP0003172_abnormal_lysosome_physiology1.51333439
37MP0000613_abnormal_salivary_gland1.48905729
38MP0004019_abnormal_vitamin_homeostasis1.46812327
39MP0002896_abnormal_bone_mineralization1.45698506
40MP0005332_abnormal_amino_acid1.44911020
41MP0005058_abnormal_lysosome_morphology1.43004749
42* MP0003953_abnormal_hormone_level1.39495312
43MP0002102_abnormal_ear_morphology1.39313226
44MP0002234_abnormal_pharynx_morphology1.39306348
45MP0004270_analgesia1.38572528
46MP0000569_abnormal_digit_pigmentation1.36747628
47MP0009643_abnormal_urine_homeostasis1.35125304
48MP0005257_abnormal_intraocular_pressure1.31868873
49MP0002138_abnormal_hepatobiliary_system1.28983777
50MP0008961_abnormal_basal_metabolism1.28710082
51MP0005075_abnormal_melanosome_morpholog1.27407681
52MP0003300_gastrointestinal_ulcer1.26577554
53MP0010678_abnormal_skin_adnexa1.25256194
54MP0005310_abnormal_salivary_gland1.23737926
55MP0004885_abnormal_endolymph1.22943455
56MP0005551_abnormal_eye_electrophysiolog1.22281343
57MP0002139_abnormal_hepatobiliary_system1.22270810
58MP0005365_abnormal_bile_salt1.21828081
59MP0001756_abnormal_urination1.16854399
60MP0001984_abnormal_olfaction1.16391058
61MP0005174_abnormal_tail_pigmentation1.15695209
62MP0003868_abnormal_feces_composition1.14971324
63MP0009745_abnormal_behavioral_response1.14152588
64MP0002090_abnormal_vision1.14089234
65MP0005535_abnormal_body_temperature1.13508666
66MP0000631_abnormal_neuroendocrine_gland1.12462925
67MP0000427_abnormal_hair_cycle1.11404274
68MP0005367_renal/urinary_system_phenotyp1.08369025
69MP0000516_abnormal_urinary_system1.08369025
70MP0001502_abnormal_circadian_rhythm1.08334153
71MP0002876_abnormal_thyroid_physiology1.08136230
72MP0001501_abnormal_sleep_pattern1.03986227
73MP0003011_delayed_dark_adaptation1.01918257
74MP0003890_abnormal_embryonic-extraembry1.01737470
75MP0003252_abnormal_bile_duct1.01175134
76MP0003633_abnormal_nervous_system1.01089890
77MP0003959_abnormal_lean_body1.00813743
78MP0002064_seizures1.00774568
79MP0006054_spinal_hemorrhage1.00041846
80MP0002272_abnormal_nervous_system0.98495522
81MP0002557_abnormal_social/conspecific_i0.95492936
82MP0003119_abnormal_digestive_system0.93014098
83MP0005253_abnormal_eye_physiology0.90896861
84MP0006036_abnormal_mitochondrial_physio0.90009172
85MP0005375_adipose_tissue_phenotype0.89001059
86MP0001905_abnormal_dopamine_level0.88049004
87MP0002822_catalepsy0.87917701
88MP0000538_abnormal_urinary_bladder0.87603701
89MP0000230_abnormal_systemic_arterial0.84650884
90MP0000681_abnormal_thyroid_gland0.84325195
91MP0001270_distended_abdomen0.84019473
92MP0005386_behavior/neurological_phenoty0.82260960
93MP0004924_abnormal_behavior0.82260960
94* MP0005636_abnormal_mineral_homeostasis0.81567336
95MP0008872_abnormal_physiological_respon0.81362271
96MP0004147_increased_porphyrin_level0.81043582
97MP0010352_gastrointestinal_tract_polyps0.78387399
98MP0000639_abnormal_adrenal_gland0.75894656
99MP0003879_abnormal_hair_cell0.73594445
100MP0002572_abnormal_emotion/affect_behav0.73593482
101MP0002295_abnormal_pulmonary_circulatio0.73369301
102MP0004510_myositis0.71460941
103MP0004215_abnormal_myocardial_fiber0.71167631
104MP0001970_abnormal_pain_threshold0.71046320
105MP0005408_hypopigmentation0.70850465
106MP0005389_reproductive_system_phenotype0.69220566
107MP0003787_abnormal_imprinting0.68503121
108MP0001661_extended_life_span0.68232513
109MP0001666_abnormal_nutrient_absorption0.66865216
110MP0004085_abnormal_heartbeat0.66536502
111MP0002751_abnormal_autonomic_nervous0.66488986
112MP0000372_irregular_coat_pigmentation0.66416879
113MP0003866_abnormal_defecation0.66412537
114MP0009672_abnormal_birth_weight0.66091912
115MP0004133_heterotaxia0.65395898
116MP0004142_abnormal_muscle_tone0.65257757
117MP0002277_abnormal_respiratory_mucosa0.64970790
118MP0000015_abnormal_ear_pigmentation0.64528095
119MP0002118_abnormal_lipid_homeostasis0.64263608
120MP0006292_abnormal_olfactory_placode0.61594219
121MP0001186_pigmentation_phenotype0.60569110
122MP0001299_abnormal_eye_distance/0.59289526
123MP0002177_abnormal_outer_ear0.59024148
124MP0005334_abnormal_fat_pad0.58779315
125MP0002733_abnormal_thermal_nociception0.58647554
126MP0003795_abnormal_bone_structure0.58158262
127MP0005452_abnormal_adipose_tissue0.57621485
128MP0002734_abnormal_mechanical_nocicepti0.55873270
129* MP0009642_abnormal_blood_homeostasis0.55699835
130MP0005670_abnormal_white_adipose0.55125462
131MP0002938_white_spotting0.54268110
132MP0005084_abnormal_gallbladder_morpholo0.53951016
133* MP0005448_abnormal_energy_balance0.53820954
134MP0009703_decreased_birth_body0.51145754
135MP0002069_abnormal_eating/drinking_beha0.50314777
136MP0002970_abnormal_white_adipose0.47114687
137MP0000163_abnormal_cartilage_morphology0.46894368
138MP0001731_abnormal_postnatal_growth0.46106119
139MP0003045_fibrosis0.46089064
140MP0001919_abnormal_reproductive_system0.42146466
141MP0001664_abnormal_digestion0.41126843
142MP0005187_abnormal_penis_morphology0.40793165
143MP0004145_abnormal_muscle_electrophysio0.40762425
144MP0002653_abnormal_ependyma_morphology0.40252106
145MP0002229_neurodegeneration0.38758885
146MP0002168_other_aberrant_phenotype0.38201571
147MP0001764_abnormal_homeostasis0.36697268
148MP0000955_abnormal_spinal_cord0.36607175

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)8.45608443
2Hypoglycemic seizures (HP:0002173)7.90005311
3Symptomatic seizures (HP:0011145)7.41406382
4Hypoglycemic coma (HP:0001325)6.91312701
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.87015078
6Hyperglycemia (HP:0003074)5.09381665
7Insulin-resistant diabetes mellitus (HP:0000831)4.98061809
8Abnormality of the pancreatic islet cells (HP:0006476)4.73639353
9Abnormality of endocrine pancreas physiology (HP:0012093)4.73639353
10Abnormality of calcium-phosphate metabolism (HP:0100530)4.64442651
11Pancreatic islet-cell hyperplasia (HP:0004510)4.60587823
12Generalized aminoaciduria (HP:0002909)4.48303664
13Ketoacidosis (HP:0001993)4.38150263
14Large for gestational age (HP:0001520)4.20127469
15Late onset (HP:0003584)4.19732836
16Decreased circulating renin level (HP:0003351)3.99585540
17Abnormal pancreas size (HP:0012094)3.92550968
18Osteomalacia (HP:0002749)3.58574035
19Mucopolysacchariduria (HP:0008155)3.48187734
20Urinary glycosaminoglycan excretion (HP:0003541)3.48187734
21Hypokalemia (HP:0002900)3.47045674
22Dysostosis multiplex (HP:0000943)3.42397883
23Enlarged penis (HP:0000040)3.25461270
24Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20908829
25Abnormality of polysaccharide metabolism (HP:0011012)3.20908829
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20908829
27Abnormality of vitamin B metabolism (HP:0004340)3.07841565
28Abnormality of the intrinsic pathway (HP:0010989)3.03164187
29Insulin resistance (HP:0000855)3.01344717
30Methylmalonic acidemia (HP:0002912)3.01241165
31Conjugated hyperbilirubinemia (HP:0002908)2.97629098
32Hyperparathyroidism (HP:0000843)2.92702970
33Double outlet right ventricle (HP:0001719)2.90677495
34Congenital malformation of the right heart (HP:0011723)2.90677495
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90676732
36Hemiparesis (HP:0001269)2.83617733
37Prominent metopic ridge (HP:0005487)2.79804044
38Abnormality of potassium homeostasis (HP:0011042)2.77113223
39Hypomagnesemia (HP:0002917)2.76176593
40Dysautonomia (HP:0002459)2.75770024
41Agitation (HP:0000713)2.73544077
42Hypoplasia of the fovea (HP:0007750)2.73114393
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.73114393
44Abnormal protein glycosylation (HP:0012346)2.69478271
45Abnormal glycosylation (HP:0012345)2.69478271
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69478271
47Abnormal protein N-linked glycosylation (HP:0012347)2.69478271
48Hypothermia (HP:0002045)2.65723329
49Abnormality of renin-angiotensin system (HP:0000847)2.63949478
50Abnormality of vitamin metabolism (HP:0100508)2.62021446
51Limb hypertonia (HP:0002509)2.60271678
52Abnormality of the fovea (HP:0000493)2.56656288
53Progressive macrocephaly (HP:0004481)2.55780460
54Ketosis (HP:0001946)2.55176774
55Retinal atrophy (HP:0001105)2.54957143
56Hyperkalemia (HP:0002153)2.54285201
57Hyperthyroidism (HP:0000836)2.51115319
58Hyperactive renin-angiotensin system (HP:0000841)2.43606074
59Thoracolumbar scoliosis (HP:0002944)2.43099158
60Abnormal drinking behavior (HP:0030082)2.41280159
61Polydipsia (HP:0001959)2.41280159
62Hypokinesia (HP:0002375)2.40881230
63Chronic bronchitis (HP:0004469)2.39711257
64Progressive neurologic deterioration (HP:0002344)2.38629210
65Type I transferrin isoform profile (HP:0003642)2.37345745
66Abnormality of the metopic suture (HP:0005556)2.36323967
67Unilateral renal agenesis (HP:0000122)2.34079293
68Abdominal distention (HP:0003270)2.33205917
69Muscular hypotonia of the trunk (HP:0008936)2.32210924
70Testicular neoplasm (HP:0010788)2.32142526
71EEG with generalized epileptiform discharges (HP:0011198)2.31884337
72Methylmalonic aciduria (HP:0012120)2.30913647
73Conjunctival hamartoma (HP:0100780)2.30783490
74Increased CSF protein (HP:0002922)2.30133502
75Hypsarrhythmia (HP:0002521)2.28832289
76Gout (HP:0001997)2.27104893
77Neoplasm of the adrenal cortex (HP:0100641)2.26943254
78Medial flaring of the eyebrow (HP:0010747)2.24179215
79Intestinal atresia (HP:0011100)2.23879288
80Epileptiform EEG discharges (HP:0011182)2.20607560
81Hematochezia (HP:0002573)2.19417034
82Hamartoma of the eye (HP:0010568)2.18404782
83Hepatic necrosis (HP:0002605)2.18304017
84Hypophosphatemia (HP:0002148)2.17835360
85Pheochromocytoma (HP:0002666)2.15402825
86Tongue fasciculations (HP:0001308)2.14932313
87Exocrine pancreatic insufficiency (HP:0001738)2.14226370
88Cortical visual impairment (HP:0100704)2.12135463
89Abnormality of the renal cortex (HP:0011035)2.11152880
90Vascular calcification (HP:0004934)2.07487601
91Type I diabetes mellitus (HP:0100651)2.07223535
92Menstrual irregularities (HP:0000858)2.06710370
93Acute necrotizing encephalopathy (HP:0006965)2.06475793
94Abnormality of magnesium homeostasis (HP:0004921)2.05905077
95Protuberant abdomen (HP:0001538)2.04621390
96Abnormal sex determination (HP:0012244)2.03992124
97Sex reversal (HP:0012245)2.03992124
98Hypoalbuminemia (HP:0003073)1.96593852
99Abnormal albumin level (HP:0012116)1.96593852
100Vacuolated lymphocytes (HP:0001922)1.94511809
101Hyperphosphaturia (HP:0003109)1.94034130
102Hypotension (HP:0002615)1.93107447
103Proximal tubulopathy (HP:0000114)1.93083331
104Abnormality of chloride homeostasis (HP:0011422)1.92611037
105Postural tremor (HP:0002174)1.92360209
106Nephronophthisis (HP:0000090)1.90855162
107Hyperphosphatemia (HP:0002905)1.90357159
108Pancreatic fibrosis (HP:0100732)1.89900293
109Furrowed tongue (HP:0000221)1.89168382
110Aqueductal stenosis (HP:0002410)1.87305908
111Bifid tongue (HP:0010297)1.87254113
112Glycosuria (HP:0003076)1.87032230
113Abnormality of urine glucose concentration (HP:0011016)1.87032230
114Macroorchidism (HP:0000053)1.86018546
115Downturned corners of mouth (HP:0002714)1.85988455
116Abnormality of liposaccharide metabolism (HP:0010968)1.84625097
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.84625097
118Abnormality of glycolipid metabolism (HP:0010969)1.84625097
119Cystic liver disease (HP:0006706)1.84512604
120Renal cortical cysts (HP:0000803)1.83665988
121Diminished movement (HP:0002374)1.83189158
122Visual hallucinations (HP:0002367)1.83087577
123Increased circulating renin level (HP:0000848)1.82357462
124Irregular vertebral endplates (HP:0003301)1.82151784
125Anxiety (HP:0000739)1.81332755
126Mitochondrial inheritance (HP:0001427)1.80899964
127Poor suck (HP:0002033)1.80491072
128Congenital stationary night blindness (HP:0007642)1.80028508
129Neuroendocrine neoplasm (HP:0100634)1.79861024
130Hypercortisolism (HP:0001578)1.79599953
131Abnormality of midbrain morphology (HP:0002418)1.78518060
132Molar tooth sign on MRI (HP:0002419)1.78518060
133Congenital glaucoma (HP:0001087)1.78471214
134Neoplasm of the adrenal gland (HP:0100631)1.78304350
135Abnormality of the vitamin B12 metabolism (HP:0004341)1.76681788
136Elevated alkaline phosphatase (HP:0003155)1.76642736
137Acute hepatic failure (HP:0006554)1.76530020
138Abnormal rod and cone electroretinograms (HP:0008323)1.76176710
139Pancreatic cysts (HP:0001737)1.75434329
140Muscle fibrillation (HP:0010546)1.75376944
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74779478
142Dicarboxylic aciduria (HP:0003215)1.74779478
143Polyuria (HP:0000103)1.74091129
144Gaze-evoked nystagmus (HP:0000640)1.73702334
145Cardiovascular calcification (HP:0011915)1.73624696
146Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72044258
147Abnormality of the common coagulation pathway (HP:0010990)1.72011601
148Hypokalemic alkalosis (HP:0001949)1.71865150
149Abnormality of small intestinal villus morphology (HP:0011472)1.71198985
150Villous atrophy (HP:0011473)1.71198985
151Abnormality of purine metabolism (HP:0004352)1.71145131
152Abnormality of alkaline phosphatase activity (HP:0004379)1.69646656
153Restlessness (HP:0000711)1.69496351
154Albinism (HP:0001022)1.68049846
155Congenital sensorineural hearing impairment (HP:0008527)1.66273203
156Papillary thyroid carcinoma (HP:0002895)1.65540878
157Abnormal biliary tract morphology (HP:0012440)1.65371388
158Metaphyseal dysplasia (HP:0100255)1.63996753
159Intention tremor (HP:0002080)1.63765987
160Decreased subcutaneous fat (HP:0001002)1.63543250
161Growth hormone excess (HP:0000845)1.63183899
162Aplasia/Hypoplasia of the macula (HP:0008059)1.62957518
163Adrenal overactivity (HP:0002717)1.62058375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.96580335
2MAPK155.62068560
3PASK5.49399424
4PRKD34.59940054
5FGFR23.72934997
6FRK2.97152777
7TAOK32.87914248
8MAP3K22.87390684
9HIPK22.81406897
10WNK32.61174673
11PHKG22.58517642
12PHKG12.58517642
13MST42.55089997
14FLT32.19259249
15MAP4K22.19189217
16DAPK22.17279758
17WNK42.10269245
18GRK11.94074290
19ERN11.92576721
20ADRBK21.88822961
21IRAK31.83477555
22TRPM71.83205467
23MAP2K61.72285880
24CDC42BPA1.68954306
25PINK11.67167504
26CSNK1G11.56090104
27NTRK11.54037198
28STK31.51447978
29PIK3CG1.48134036
30IRAK11.46690893
31CAMKK21.39356101
32UHMK11.38170517
33TNIK1.37501886
34CASK1.31570193
35ACVR1B1.26016531
36AKT31.24752870
37EPHA31.24480549
38NTRK31.23316737
39MAP3K41.22528936
40PRKD21.18765097
41SCYL21.18195239
42PRKCH1.17795556
43BRD41.17091093
44STK391.12725669
45EIF2AK31.12571621
46BRSK21.11499787
47TRIM281.11472188
48NUAK11.11070352
49PTK21.10318566
50MAP3K11.10094796
51PTK2B1.06491312
52PDGFRA1.06164351
53CSNK1G31.03901906
54OXSR11.02637184
55STK240.96756784
56CSNK1G20.94709897
57BCKDK0.93140713
58DYRK1B0.89965345
59MET0.89598006
60PAK30.89236412
61YES10.89230769
62PRKCG0.89222489
63PRKAA20.87808767
64PLK20.85890566
65MAP3K120.84368440
66MAP2K20.83121952
67MAP3K90.80189953
68BMPR20.77968817
69BRAF0.76189890
70TNK20.74779015
71MKNK20.73675467
72PTK60.73417992
73STK110.72126391
74IRAK20.71250532
75MAP3K30.70301474
76NLK0.66603796
77WNK10.65778128
78PRKCE0.65115556
79STK40.60125627
80PRKCI0.59621976
81ITK0.59355635
82CDK30.58428897
83ZAK0.56154021
84BMPR1B0.54219404
85NEK60.53181683
86ERBB30.52720423
87STK160.50094719
88ADRBK10.48854680
89IRAK40.48239196
90PLK30.48081016
91RPS6KA20.46768893
92SGK30.45344084
93CAMK2D0.44435562
94PRKAA10.43862640
95JAK20.42310995
96MAP2K70.42282977
97LIMK10.42017009
98BRSK10.41426161
99FER0.40204267
100PRKG10.40047229
101TEC0.39954936
102CSNK1A1L0.39889717
103EPHA20.39026501
104RET0.38655883
105RPS6KB10.38474005
106STK38L0.37048001
107CSNK1A10.37043708
108CAMK2A0.36823218
109PNCK0.36689747
110JAK30.36450613
111MAPK130.31493051
112CSNK1D0.31396217
113ROCK10.31103809
114CHUK0.30719266
115ZAP700.30711329
116PRKACG0.30455720
117TESK10.30332722
118PRKCZ0.30182586
119PRKDC0.29551533
120SGK20.29475584
121BCR0.29374913
122GSK3A0.28334682
123TRIB30.28202150
124DAPK10.27891671
125SGK4940.27821749
126SGK2230.27821749
127CSK0.27405133
128FGFR40.27227449
129PRKACB0.26901930
130SIK10.26583282
131JAK10.25773406
132PRKD10.25364383
133DYRK1A0.25222196
134MTOR0.25207449
135PRKACA0.24597150
136IGF1R0.24191173
137VRK10.21678402
138CSNK1E0.21005201
139LMTK20.20964631
140ATM0.20793987
141CAMK2B0.19865022
142MAPK140.19608946
143CDK50.18522433
144CAMKK10.18428181
145AKT10.17262648
146PRKG20.16553159
147PRKCA0.16330087
148MARK20.16191919
149MAPK30.15162680
150BTK0.15153838
151FGFR30.14383148
152SGK10.14161963
153DYRK30.13679947
154RPS6KA30.12910056

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049509.33841745
2Protein export_Homo sapiens_hsa030606.44685902
3Sulfur metabolism_Homo sapiens_hsa009203.63145353
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.30055783
5Insulin secretion_Homo sapiens_hsa049113.25852849
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18819439
7Vibrio cholerae infection_Homo sapiens_hsa051102.15074700
8Type II diabetes mellitus_Homo sapiens_hsa049302.12657656
9Type I diabetes mellitus_Homo sapiens_hsa049402.06030276
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.01174822
11Vitamin B6 metabolism_Homo sapiens_hsa007501.96867228
12N-Glycan biosynthesis_Homo sapiens_hsa005101.85113706
13Selenocompound metabolism_Homo sapiens_hsa004501.78139677
14Oxidative phosphorylation_Homo sapiens_hsa001901.76262611
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63762996
16Cocaine addiction_Homo sapiens_hsa050301.53924973
17Lysosome_Homo sapiens_hsa041421.42938879
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.41835525
19Other glycan degradation_Homo sapiens_hsa005111.37235000
20Regulation of autophagy_Homo sapiens_hsa041401.34724732
21Circadian rhythm_Homo sapiens_hsa047101.31327382
22Propanoate metabolism_Homo sapiens_hsa006401.27542413
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26395507
24Phototransduction_Homo sapiens_hsa047441.22326684
25Folate biosynthesis_Homo sapiens_hsa007901.20825705
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19859917
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12153964
28Amphetamine addiction_Homo sapiens_hsa050311.09253235
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08868759
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08160098
31Ether lipid metabolism_Homo sapiens_hsa005651.07249948
32Glucagon signaling pathway_Homo sapiens_hsa049221.06218285
33Fatty acid metabolism_Homo sapiens_hsa012121.03936067
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03590823
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03389395
36Galactose metabolism_Homo sapiens_hsa000521.02653570
37Taste transduction_Homo sapiens_hsa047420.99306323
38Tryptophan metabolism_Homo sapiens_hsa003800.98036763
39beta-Alanine metabolism_Homo sapiens_hsa004100.94709694
40ABC transporters_Homo sapiens_hsa020100.93746075
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92191978
42Thyroid hormone synthesis_Homo sapiens_hsa049180.91836824
43Mineral absorption_Homo sapiens_hsa049780.89620851
44Insulin resistance_Homo sapiens_hsa049310.88775009
45Pancreatic secretion_Homo sapiens_hsa049720.86474026
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85221245
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83179481
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81628423
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.81322441
50Prolactin signaling pathway_Homo sapiens_hsa049170.80017430
51Butanoate metabolism_Homo sapiens_hsa006500.78524529
52Parkinsons disease_Homo sapiens_hsa050120.78354947
53Prion diseases_Homo sapiens_hsa050200.78190118
54Collecting duct acid secretion_Homo sapiens_hsa049660.76346035
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74981610
56Sphingolipid metabolism_Homo sapiens_hsa006000.74641601
57Alzheimers disease_Homo sapiens_hsa050100.68900943
58Dopaminergic synapse_Homo sapiens_hsa047280.68463583
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65630538
60Starch and sucrose metabolism_Homo sapiens_hsa005000.64934730
61Phenylalanine metabolism_Homo sapiens_hsa003600.64735546
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62687530
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62545404
64Synaptic vesicle cycle_Homo sapiens_hsa047210.61541698
65Serotonergic synapse_Homo sapiens_hsa047260.61370122
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60203662
67Circadian entrainment_Homo sapiens_hsa047130.59955427
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59575411
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59109986
70Long-term potentiation_Homo sapiens_hsa047200.58676887
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58513946
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57068548
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56558986
74Linoleic acid metabolism_Homo sapiens_hsa005910.56177384
75Cardiac muscle contraction_Homo sapiens_hsa042600.56010453
76Retinol metabolism_Homo sapiens_hsa008300.55655173
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55620655
78Cholinergic synapse_Homo sapiens_hsa047250.54617238
79Salivary secretion_Homo sapiens_hsa049700.53861478
80Long-term depression_Homo sapiens_hsa047300.53769442
81GABAergic synapse_Homo sapiens_hsa047270.51738870
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51449295
83Glutathione metabolism_Homo sapiens_hsa004800.51332042
84Glutamatergic synapse_Homo sapiens_hsa047240.50722747
85Estrogen signaling pathway_Homo sapiens_hsa049150.48746133
86Alcoholism_Homo sapiens_hsa050340.47393938
87Histidine metabolism_Homo sapiens_hsa003400.46656900
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45199081
89Insulin signaling pathway_Homo sapiens_hsa049100.44435992
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.43171547
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42573302
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41227775
93Chemical carcinogenesis_Homo sapiens_hsa052040.39720460
94Caffeine metabolism_Homo sapiens_hsa002320.37924946
95Tyrosine metabolism_Homo sapiens_hsa003500.37613672
96Arachidonic acid metabolism_Homo sapiens_hsa005900.37609326
97Nicotine addiction_Homo sapiens_hsa050330.37540939
98Nitrogen metabolism_Homo sapiens_hsa009100.37356818
99Antigen processing and presentation_Homo sapiens_hsa046120.36998116
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36890307
101Purine metabolism_Homo sapiens_hsa002300.36304847
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35672626
103Lysine degradation_Homo sapiens_hsa003100.34973922
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34669018
105Fatty acid elongation_Homo sapiens_hsa000620.33472732
106Arginine biosynthesis_Homo sapiens_hsa002200.31101899
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30798716
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30432530
109Inositol phosphate metabolism_Homo sapiens_hsa005620.30389294
110Fructose and mannose metabolism_Homo sapiens_hsa000510.29247856
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27677902
112Morphine addiction_Homo sapiens_hsa050320.27288931
113Legionellosis_Homo sapiens_hsa051340.27286677
114Thyroid cancer_Homo sapiens_hsa052160.25560609
115Fat digestion and absorption_Homo sapiens_hsa049750.24243128
116Phagosome_Homo sapiens_hsa041450.23519091
117AMPK signaling pathway_Homo sapiens_hsa041520.22719711
118Renin secretion_Homo sapiens_hsa049240.22436311
119Prostate cancer_Homo sapiens_hsa052150.20653096
120cAMP signaling pathway_Homo sapiens_hsa040240.20005984
121Protein digestion and absorption_Homo sapiens_hsa049740.19526528
122mTOR signaling pathway_Homo sapiens_hsa041500.19003759
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18579500
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.17527216
125Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17322600
126Fatty acid degradation_Homo sapiens_hsa000710.16176074
127FoxO signaling pathway_Homo sapiens_hsa040680.15066065
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.14348039
129Ovarian steroidogenesis_Homo sapiens_hsa049130.14071143
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10685291
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10139906
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.09815965
133Metabolic pathways_Homo sapiens_hsa011000.08381400
134Dorso-ventral axis formation_Homo sapiens_hsa043200.08344359
135Bladder cancer_Homo sapiens_hsa052190.07653182
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.05752916
137Peroxisome_Homo sapiens_hsa041460.05155866
138Melanogenesis_Homo sapiens_hsa049160.04702840
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.03817219
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.02593689

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »