SLC31A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.63844803
2L-phenylalanine catabolic process (GO:0006559)6.63844803
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31843417
4L-phenylalanine metabolic process (GO:0006558)6.31843417
5aromatic amino acid family catabolic process (GO:0009074)5.97679943
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.65017679
7tryptophan metabolic process (GO:0006568)5.53007537
8indole-containing compound catabolic process (GO:0042436)5.45501738
9indolalkylamine catabolic process (GO:0046218)5.45501738
10tryptophan catabolic process (GO:0006569)5.45501738
11cysteine metabolic process (GO:0006534)5.45473687
12kynurenine metabolic process (GO:0070189)5.30951247
13glyoxylate metabolic process (GO:0046487)5.30747313
14alpha-linolenic acid metabolic process (GO:0036109)5.09078499
15bile acid biosynthetic process (GO:0006699)5.07513283
16sulfur amino acid catabolic process (GO:0000098)5.05907849
17urea metabolic process (GO:0019627)4.98589119
18urea cycle (GO:0000050)4.98589119
19high-density lipoprotein particle remodeling (GO:0034375)4.93811239
20protein carboxylation (GO:0018214)4.89936141
21peptidyl-glutamic acid carboxylation (GO:0017187)4.89936141
22tyrosine metabolic process (GO:0006570)4.82222119
23negative regulation of fibrinolysis (GO:0051918)4.80500084
24complement activation, alternative pathway (GO:0006957)4.68431729
25lysine metabolic process (GO:0006553)4.64006926
26lysine catabolic process (GO:0006554)4.64006926
27regulation of fibrinolysis (GO:0051917)4.62713803
28serine family amino acid catabolic process (GO:0009071)4.60877021
29regulation of protein activation cascade (GO:2000257)4.60735430
30homocysteine metabolic process (GO:0050667)4.58445054
31regulation of cholesterol esterification (GO:0010872)4.56875416
32nitrogen cycle metabolic process (GO:0071941)4.55190079
33aromatic amino acid family metabolic process (GO:0009072)4.53580048
34reverse cholesterol transport (GO:0043691)4.50626512
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.48239574
36Golgi transport vesicle coating (GO:0048200)4.48015061
37COPI coating of Golgi vesicle (GO:0048205)4.48015061
38epoxygenase P450 pathway (GO:0019373)4.37398610
39regulation of triglyceride catabolic process (GO:0010896)4.35886302
40plasma lipoprotein particle remodeling (GO:0034369)4.34501356
41protein-lipid complex remodeling (GO:0034368)4.34501356
42macromolecular complex remodeling (GO:0034367)4.34501356
43bile acid metabolic process (GO:0008206)4.33245362
44regulation of complement activation (GO:0030449)4.33085838
45amino-acid betaine metabolic process (GO:0006577)4.28292642
46cellular glucuronidation (GO:0052695)4.23137272
47phospholipid efflux (GO:0033700)4.21655980
48indolalkylamine metabolic process (GO:0006586)4.18076526
49negative regulation of cholesterol transport (GO:0032375)4.10141922
50negative regulation of sterol transport (GO:0032372)4.10141922
51aldehyde catabolic process (GO:0046185)4.10002786
52plasma lipoprotein particle clearance (GO:0034381)4.09159156
53bile acid and bile salt transport (GO:0015721)4.08886486
54primary alcohol catabolic process (GO:0034310)4.08072067
55benzene-containing compound metabolic process (GO:0042537)4.06737949
56exogenous drug catabolic process (GO:0042738)4.05153523
57alpha-amino acid catabolic process (GO:1901606)4.01730868
58triglyceride homeostasis (GO:0070328)4.01338764
59acylglycerol homeostasis (GO:0055090)4.01338764
60glucuronate metabolic process (GO:0019585)3.97233299
61uronic acid metabolic process (GO:0006063)3.97233299
62ethanol oxidation (GO:0006069)3.96958015
63L-serine metabolic process (GO:0006563)3.92714778
64cholesterol efflux (GO:0033344)3.92660617
65response to nitrosative stress (GO:0051409)3.87352540
66drug catabolic process (GO:0042737)3.85700673
67serine family amino acid metabolic process (GO:0009069)3.84663149
68omega-hydroxylase P450 pathway (GO:0097267)3.83651476
69cellular biogenic amine catabolic process (GO:0042402)3.79685730
70amine catabolic process (GO:0009310)3.79685730
71urate metabolic process (GO:0046415)3.74021775
72cellular ketone body metabolic process (GO:0046950)3.73108192
73cellular amino acid catabolic process (GO:0009063)3.73036950
74cellular modified amino acid catabolic process (GO:0042219)3.72779809
75fat-soluble vitamin biosynthetic process (GO:0042362)3.71565786
76fibrinolysis (GO:0042730)3.70286038
77glycine metabolic process (GO:0006544)3.69788548
78plasma lipoprotein particle assembly (GO:0034377)3.68556319
79low-density lipoprotein particle remodeling (GO:0034374)3.67987043
80iron ion import (GO:0097286)3.67361344
81intestinal cholesterol absorption (GO:0030299)3.66004666
82arginine metabolic process (GO:0006525)3.65390744
83UDP-N-acetylglucosamine metabolic process (GO:0006047)3.64739223
84phospholipid homeostasis (GO:0055091)3.64504836
85ethanol metabolic process (GO:0006067)3.59707664
86glutamate metabolic process (GO:0006536)3.59249357
87L-ascorbic acid metabolic process (GO:0019852)3.55178845
88coenzyme catabolic process (GO:0009109)3.53438611
89positive regulation of triglyceride lipase activity (GO:0061365)3.53374689
90positive regulation of lipoprotein lipase activity (GO:0051006)3.53374689
91serine family amino acid biosynthetic process (GO:0009070)3.51149438
92flavonoid metabolic process (GO:0009812)3.49184369
93cholesterol homeostasis (GO:0042632)3.48947451
94drug transmembrane transport (GO:0006855)3.48724082
95regulation of cholesterol homeostasis (GO:2000188)3.48364350
96regulation of bile acid biosynthetic process (GO:0070857)3.47494613
97imidazole-containing compound metabolic process (GO:0052803)3.46711540
98sterol homeostasis (GO:0055092)3.45580644
99short-chain fatty acid metabolic process (GO:0046459)3.44193024
100lipoprotein metabolic process (GO:0042157)3.42720097
101xenobiotic catabolic process (GO:0042178)3.42127964
102positive regulation of lipid catabolic process (GO:0050996)3.41368342
103plasma lipoprotein particle organization (GO:0071827)3.40474470
104heme transport (GO:0015886)3.35008694
105cofactor catabolic process (GO:0051187)3.34684102
106COPII vesicle coating (GO:0048208)3.33657110
107carboxylic acid catabolic process (GO:0046395)3.33463770
108organic acid catabolic process (GO:0016054)3.33463770
109very-low-density lipoprotein particle assembly (GO:0034379)3.31326455
110dicarboxylic acid biosynthetic process (GO:0043650)3.30821150
111oligosaccharide catabolic process (GO:0009313)3.28204019
112protein-lipid complex assembly (GO:0065005)3.27678143
113acute-phase response (GO:0006953)3.26778983
114glycosphingolipid catabolic process (GO:0046479)3.25410007
115ketone body metabolic process (GO:1902224)3.24170299
116negative regulation of protein activation cascade (GO:2000258)3.21103556
117negative regulation of lipase activity (GO:0060192)3.16477329
118nucleotide-sugar biosynthetic process (GO:0009226)3.11139570
119drug metabolic process (GO:0017144)3.10516507
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.05555020
121intestinal absorption (GO:0050892)3.02073568
122negative regulation of coagulation (GO:0050819)2.98219525
123regulation of apoptotic cell clearance (GO:2000425)2.97507386
124glycolipid catabolic process (GO:0019377)2.97341862
125negative regulation of blood coagulation (GO:0030195)2.94497147
126negative regulation of hemostasis (GO:1900047)2.94497147
127pyrimidine-containing compound transmembrane transport (GO:0072531)2.94473396
128vitamin transmembrane transport (GO:0035461)2.92108008
129protein-lipid complex subunit organization (GO:0071825)2.91606700
130proline metabolic process (GO:0006560)2.89232323
131gap junction assembly (GO:0016264)2.88967851
132vitamin biosynthetic process (GO:0009110)2.88872293
133cellular aldehyde metabolic process (GO:0006081)2.82079972
134midgut development (GO:0007494)2.78295246
135negative regulation of complement activation (GO:0045916)2.75364326
136primary alcohol metabolic process (GO:0034308)2.74461334
137negative regulation of fatty acid biosynthetic process (GO:0045717)2.72023321
138negative regulation of wound healing (GO:0061045)2.71588371
139L-alpha-amino acid transmembrane transport (GO:1902475)2.67926947
140apoptotic cell clearance (GO:0043277)2.66534273
141regulation of plasminogen activation (GO:0010755)2.66296916
142proline biosynthetic process (GO:0006561)2.66126958
143ceramide catabolic process (GO:0046514)2.65513142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.32075994
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.48036638
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.00119252
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.76801660
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97281066
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74178855
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.38326203
8E2F7_22180533_ChIP-Seq_HELA_Human3.49704546
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.44820680
10* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.37314911
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57407091
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55652556
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.49713564
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.45605886
15CLOCK_20551151_ChIP-Seq_293T_Human2.37002867
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.20741869
17PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.20062452
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01247233
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5476567
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.90410668
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88537780
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.81244016
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.79866261
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77732179
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60429905
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59170984
27* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59112282
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55566197
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55260620
30* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53494114
31GATA1_22025678_ChIP-Seq_K562_Human1.53255627
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.52296599
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.52282142
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51834598
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47413509
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47282665
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47200604
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44710790
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44540849
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43170840
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39697889
42EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38717686
43ELK1_19687146_ChIP-ChIP_HELA_Human1.38715978
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37356414
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.35530098
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.35382048
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34826874
48GATA4_25053715_ChIP-Seq_YYC3_Human1.33350355
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.31788754
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31466293
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29646752
52* SOX17_20123909_ChIP-Seq_XEN_Mouse1.27016401
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.25616621
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22423490
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22347411
56* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20484069
57TFEB_21752829_ChIP-Seq_HELA_Human1.19734212
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.18751859
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18221004
60DCP1A_22483619_ChIP-Seq_HELA_Human1.16513955
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13208180
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.13167816
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12125480
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10368221
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.09412456
66SOX2_20726797_ChIP-Seq_SW620_Human1.08204717
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05490439
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03478857
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.03442094
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.02758895
71ZNF263_19887448_ChIP-Seq_K562_Human1.01878520
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01001891
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00032371
74SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00032371
75PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95894635
76* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94629712
77CDX2_20551321_ChIP-Seq_CACO-2_Human0.93609493
78KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92295328
79FOXO3_23340844_ChIP-Seq_DLD1_Human0.91515330
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90600090
81* SRF_21415370_ChIP-Seq_HL-1_Mouse0.89915850
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89756470
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89684837
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89479108
85NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88917202
86HTT_18923047_ChIP-ChIP_STHdh_Human0.88540190
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88444754
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.88355022
89IRF8_27001747_Chip-Seq_BMDM_Mouse0.88058636
90NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.87474024
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87125756
92ETS1_20019798_ChIP-Seq_JURKAT_Human0.86143782
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86118313
94* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85906046
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85569319
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85470717
97ELF5_23300383_ChIP-Seq_T47D_Human0.84893140
98CHD1_26751641_Chip-Seq_LNCaP_Human0.84801969
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84407249
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83929887
101EOMES_21245162_ChIP-Seq_HESCs_Human0.83868526
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83027896
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82855009
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82855009
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82852960
106GATA6_25053715_ChIP-Seq_YYC3_Human0.81622055
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81117050
108* E2F1_21310950_ChIP-Seq_MCF-7_Human0.80061222
109* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79968909
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78847242
111AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78462788
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78238782
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.76055050
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.76055050
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.76055050
116BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.75951225
117AR_21909140_ChIP-Seq_LNCAP_Human0.75783423
118CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.70218996
119GATA3_24758297_ChIP-Seq_MCF-7_Human0.69395539
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67479275
121CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66829233
122TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65055147
123EGR1_19032775_ChIP-ChIP_M12_Human0.64762418
124CEBPB_22108803_ChIP-Seq_LS180_Human0.63568049
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.62325538
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62165745
127PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.62001237
128MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61266480
129RACK7_27058665_Chip-Seq_MCF-7_Human0.59123787
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.58960275
131RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58299283
132CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.57435606
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57226683
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.57133183
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.56748062
136GATA1_19941826_ChIP-Seq_K562_Human0.56646131
137GATA2_19941826_ChIP-Seq_K562_Human0.56447950
138LXR_22292898_ChIP-Seq_THP-1_Human0.56104046
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.55697028
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.55361626
141* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55084921
142FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53899989
143BCAT_22108803_ChIP-Seq_LS180_Human0.52889166
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.52528522
145RARA_24833708_ChIP-Seq_LIVER_Mouse0.51611368
146SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.51501346
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50188316
148AR_20517297_ChIP-Seq_VCAP_Human0.50019317
149ATF3_27146783_Chip-Seq_COLON_Human0.49560322
150CDX2_22108803_ChIP-Seq_LS180_Human0.48701843

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.23486471
2MP0005360_urolithiasis7.02559412
3MP0005085_abnormal_gallbladder_physiolo5.78196852
4MP0005365_abnormal_bile_salt5.14360608
5MP0008875_abnormal_xenobiotic_pharmacok4.67125004
6MP0003806_abnormal_nucleotide_metabolis3.73413984
7MP0003252_abnormal_bile_duct3.47049736
8MP0009840_abnormal_foam_cell3.15393012
9MP0010329_abnormal_lipoprotein_level3.13478857
10MP0003941_abnormal_skin_development3.12631323
11MP0005083_abnormal_biliary_tract2.97111652
12MP0005332_abnormal_amino_acid2.66023189
13MP0003195_calcinosis2.65898360
14MP0001666_abnormal_nutrient_absorption2.60677120
15MP0004019_abnormal_vitamin_homeostasis2.36675581
16MP0003191_abnormal_cellular_cholesterol2.14713371
17* MP0000609_abnormal_liver_physiology1.95663590
18MP0003186_abnormal_redox_activity1.85668920
19MP0002138_abnormal_hepatobiliary_system1.84756017
20MP0005257_abnormal_intraocular_pressure1.82379181
21MP0003950_abnormal_plasma_membrane1.80966620
22MP0002118_abnormal_lipid_homeostasis1.79085866
23MP0010352_gastrointestinal_tract_polyps1.78290132
24MP0005319_abnormal_enzyme/_coenzyme1.75597285
25MP0003890_abnormal_embryonic-extraembry1.65307761
26MP0009697_abnormal_copulation1.64057375
27MP0003705_abnormal_hypodermis_morpholog1.59245740
28MP0009643_abnormal_urine_homeostasis1.59122339
29MP0003566_abnormal_cell_adhesion1.55506381
30MP0006054_spinal_hemorrhage1.53534007
31MP0005584_abnormal_enzyme/coenzyme_acti1.40530073
32MP0001764_abnormal_homeostasis1.40329621
33MP0004957_abnormal_blastocyst_morpholog1.40193859
34MP0009764_decreased_sensitivity_to1.38054407
35MP0003868_abnormal_feces_composition1.36866711
36MP0003656_abnormal_erythrocyte_physiolo1.33167146
37MP0003136_yellow_coat_color1.30512921
38MP0002877_abnormal_melanocyte_morpholog1.29732221
39MP0003693_abnormal_embryo_hatching1.27886068
40MP0003011_delayed_dark_adaptation1.24788800
41MP0002090_abnormal_vision1.19583100
42MP0000598_abnormal_liver_morphology1.16916912
43MP0003436_decreased_susceptibility_to1.16856124
44* MP0004272_abnormal_basement_membrane1.15203855
45MP0005451_abnormal_body_composition1.14286761
46MP0002822_catalepsy1.10901644
47MP0010368_abnormal_lymphatic_system1.08850719
48MP0001756_abnormal_urination1.08104914
49MP0002938_white_spotting1.05123368
50MP0010678_abnormal_skin_adnexa1.04691232
51MP0005501_abnormal_skin_physiology1.04634974
52MP0008469_abnormal_protein_level1.04595054
53* MP0005408_hypopigmentation1.04298272
54MP0008007_abnormal_cellular_replicative1.03850328
55* MP0005636_abnormal_mineral_homeostasis1.03026915
56MP0003724_increased_susceptibility_to1.02561461
57MP0001915_intracranial_hemorrhage1.00065081
58MP0009763_increased_sensitivity_to0.98862656
59MP0005167_abnormal_blood-brain_barrier0.97908470
60MP0000647_abnormal_sebaceous_gland0.97741760
61MP0004233_abnormal_muscle_weight0.96486944
62MP0002254_reproductive_system_inflammat0.95856260
63MP0000604_amyloidosis0.93929989
64MP0009053_abnormal_anal_canal0.91827993
65MP0004782_abnormal_surfactant_physiolog0.90439895
66MP0003172_abnormal_lysosome_physiology0.89390466
67MP0005647_abnormal_sex_gland0.88812334
68MP0005197_abnormal_uvea_morphology0.86121428
69MP0008932_abnormal_embryonic_tissue0.85859868
70MP0001324_abnormal_eye_pigmentation0.83737351
71* MP0009642_abnormal_blood_homeostasis0.83366667
72MP0005220_abnormal_exocrine_pancreas0.83053285
73MP0003300_gastrointestinal_ulcer0.82688008
74MP0002136_abnormal_kidney_physiology0.81562602
75MP0005084_abnormal_gallbladder_morpholo0.81494243
76MP0001216_abnormal_epidermal_layer0.81482075
77MP0005275_abnormal_skin_tensile0.80250105
78MP0001730_embryonic_growth_arrest0.80167700
79MP0005058_abnormal_lysosome_morphology0.78046002
80MP0002060_abnormal_skin_morphology0.78044964
81MP0010307_abnormal_tumor_latency0.77069080
82MP0005376_homeostasis/metabolism_phenot0.75612160
83MP0002896_abnormal_bone_mineralization0.74972019
84MP0003111_abnormal_nucleus_morphology0.74442470
85MP0009672_abnormal_birth_weight0.74389025
86MP0001661_extended_life_span0.72891332
87MP0009384_cardiac_valve_regurgitation0.72676978
88MP0005670_abnormal_white_adipose0.72113237
89MP0005248_abnormal_Harderian_gland0.71557057
90MP0000383_abnormal_hair_follicle0.70207122
91MP0000377_abnormal_hair_follicle0.69633410
92MP0008438_abnormal_cutaneous_collagen0.67869996
93MP0001672_abnormal_embryogenesis/_devel0.66420432
94MP0005380_embryogenesis_phenotype0.66420432
95MP0005171_absent_coat_pigmentation0.66030076
96MP0002697_abnormal_eye_size0.63744272
97MP0002282_abnormal_trachea_morphology0.63412675
98MP0003984_embryonic_growth_retardation0.63251555
99MP0004883_abnormal_blood_vessel0.62998305
100MP0002295_abnormal_pulmonary_circulatio0.62502335
101MP0000371_diluted_coat_color0.62114747
102MP0003937_abnormal_limbs/digits/tail_de0.62108266
103MP0000358_abnormal_cell_content/0.61437977
104MP0002088_abnormal_embryonic_growth/wei0.61393884
105MP0005464_abnormal_platelet_physiology0.61314856
106MP0004147_increased_porphyrin_level0.61215407
107* MP0002086_abnormal_extraembryonic_tissu0.60120809
108MP0009765_abnormal_xenobiotic_induced0.59999270
109MP0001849_ear_inflammation0.59185974
110MP0001533_abnormal_skeleton_physiology0.59054255
111MP0000249_abnormal_blood_vessel0.58731881
112MP0004264_abnormal_extraembryonic_tissu0.58679802
113MP0003448_altered_tumor_morphology0.58664336
114MP0005395_other_phenotype0.58660724
115MP0000538_abnormal_urinary_bladder0.58379209
116MP0003690_abnormal_glial_cell0.58167533
117* MP0002098_abnormal_vibrissa_morphology0.58000000
118MP0006082_CNS_inflammation0.57669362
119MP0005166_decreased_susceptibility_to0.57538662
120MP0008004_abnormal_stomach_pH0.57514772
121MP0010234_abnormal_vibrissa_follicle0.57299008
122MP0002078_abnormal_glucose_homeostasis0.56822174
123MP0002132_abnormal_respiratory_system0.56288894
124MP0005266_abnormal_metabolism0.55595332
125MP0005164_abnormal_response_to0.55410250
126MP0001881_abnormal_mammary_gland0.54967830
127MP0005023_abnormal_wound_healing0.54720012
128MP0005334_abnormal_fat_pad0.54369402
129MP0001845_abnormal_inflammatory_respons0.54168617
130MP0002971_abnormal_brown_adipose0.53891137
131MP0009785_altered_susceptibility_to0.53076878
132MP0002796_impaired_skin_barrier0.52384666
133MP0003638_abnormal_response/metabolism_0.51944415
134MP0004947_skin_inflammation0.51100034
135MP0004043_abnormal_pH_regulation0.50391291
136MP0002876_abnormal_thyroid_physiology0.50070526
137MP0002168_other_aberrant_phenotype0.49825890
138MP0005666_abnormal_adipose_tissue0.49235671
139MP0002419_abnormal_innate_immunity0.49202755
140MP0006036_abnormal_mitochondrial_physio0.48938704
141MP0003279_aneurysm0.48762740
142MP0003453_abnormal_keratinocyte_physiol0.45755653
143MP0005535_abnormal_body_temperature0.45700468
144MP0003718_maternal_effect0.44877680
145MP0000639_abnormal_adrenal_gland0.44653708
146MP0001853_heart_inflammation0.43820323
147MP0002277_abnormal_respiratory_mucosa0.43724239
148MP0008873_increased_physiological_sensi0.43409782
149MP0005448_abnormal_energy_balance0.41663822

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.48625526
2Intrahepatic cholestasis (HP:0001406)6.42842500
3Deep venous thrombosis (HP:0002625)6.36022298
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.27089204
5Xanthomatosis (HP:0000991)5.59944478
6Prolonged partial thromboplastin time (HP:0003645)5.46659142
7Hypobetalipoproteinemia (HP:0003563)5.45779102
8Complement deficiency (HP:0004431)4.83276524
9Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56834210
10Hyperlipoproteinemia (HP:0010980)4.41688251
11Joint hemorrhage (HP:0005261)4.29857881
12Abnormality of the common coagulation pathway (HP:0010990)4.23969991
13Hypolipoproteinemia (HP:0010981)4.20225825
14Fat malabsorption (HP:0002630)4.09915359
15Hyperammonemia (HP:0001987)4.05161624
16Hyperglycinuria (HP:0003108)3.97333537
17Epidermoid cyst (HP:0200040)3.83049922
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.81940933
19Hyperglycinemia (HP:0002154)3.79052330
20Ketosis (HP:0001946)3.79024775
21Conjugated hyperbilirubinemia (HP:0002908)3.77709512
22Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.75701505
23Hypoglycemic coma (HP:0001325)3.74131276
24Hypoalphalipoproteinemia (HP:0003233)3.72385149
25Abnormality of serine family amino acid metabolism (HP:0010894)3.66444941
26Abnormality of glycine metabolism (HP:0010895)3.66444941
27Vacuolated lymphocytes (HP:0001922)3.65186046
28Abnormality of pyrimidine metabolism (HP:0004353)3.64703987
29Abnormality of complement system (HP:0005339)3.61574666
30Abnormality of glycolipid metabolism (HP:0010969)3.56617259
31Abnormality of liposaccharide metabolism (HP:0010968)3.56617259
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.56617259
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54825147
34Abnormality of the intrinsic pathway (HP:0010989)3.46139474
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34484111
36Abnormality of nucleobase metabolism (HP:0010932)3.30452318
37Hypercholesterolemia (HP:0003124)3.29994217
38Vascular calcification (HP:0004934)3.26106830
39Abnormality of methionine metabolism (HP:0010901)3.22099365
40Steatorrhea (HP:0002570)3.20999593
41Abnormality of fatty-acid metabolism (HP:0004359)3.17891644
42Systemic lupus erythematosus (HP:0002725)3.17758351
43Abnormality of purine metabolism (HP:0004352)3.13326484
44Hepatocellular carcinoma (HP:0001402)3.04507266
45Abnormality of glycolysis (HP:0004366)3.04246365
46Increased serum pyruvate (HP:0003542)3.00465825
47Gout (HP:0001997)2.98392413
48Rhinitis (HP:0012384)2.96193016
49Cardiovascular calcification (HP:0011915)2.95402985
50Myocardial infarction (HP:0001658)2.94180292
51Ketoacidosis (HP:0001993)2.91047447
52Hyperbilirubinemia (HP:0002904)2.88945055
53Metabolic acidosis (HP:0001942)2.83222343
54Delayed CNS myelination (HP:0002188)2.80517375
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.80289288
56Spastic diplegia (HP:0001264)2.79122665
57Chronic bronchitis (HP:0004469)2.77000235
58Esophageal varix (HP:0002040)2.70842631
59Recurrent gram-negative bacterial infections (HP:0005420)2.66060914
60Glomerulonephritis (HP:0000099)2.62861905
61Abnormal gallbladder physiology (HP:0012438)2.62460963
62Cholecystitis (HP:0001082)2.62460963
63Abnormal respiratory motile cilium physiology (HP:0012261)2.55436399
64Hydroxyprolinuria (HP:0003080)2.51212570
65Abnormality of proline metabolism (HP:0010907)2.51212570
66Malnutrition (HP:0004395)2.50521741
67Generalized aminoaciduria (HP:0002909)2.49490301
68Skin nodule (HP:0200036)2.45732420
69Lethargy (HP:0001254)2.39236092
70Multiple enchondromatosis (HP:0005701)2.38977087
71Irritability (HP:0000737)2.38041292
72Spontaneous abortion (HP:0005268)2.37281631
73Renal tubular acidosis (HP:0001947)2.37020048
74Increased cerebral lipofuscin (HP:0011813)2.35388216
75Abnormality of serum amino acid levels (HP:0003112)2.33844361
76Nausea (HP:0002018)2.32603692
77Dicarboxylic aciduria (HP:0003215)2.31857725
78Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31857725
79Abnormal respiratory motile cilium morphology (HP:0005938)2.29598550
80Abnormal respiratory epithelium morphology (HP:0012253)2.29598550
81Abnormality of transition element cation homeostasis (HP:0011030)2.22182344
82Mitral stenosis (HP:0001718)2.21978103
83Alkalosis (HP:0001948)2.19486297
84Hypoglycemic seizures (HP:0002173)2.18121697
85Sensorimotor neuropathy (HP:0007141)2.17827534
86Menorrhagia (HP:0000132)2.15765692
87Hemorrhage of the eye (HP:0011885)2.15538968
88Proximal tubulopathy (HP:0000114)2.12523734
89Abnormal ciliary motility (HP:0012262)2.11090606
90Abnormal cartilage morphology (HP:0002763)2.10593532
91Abnormality of iron homeostasis (HP:0011031)2.09303137
92Abnormal gallbladder morphology (HP:0012437)2.07293698
93Congenital ichthyosiform erythroderma (HP:0007431)2.06657354
94Increased purine levels (HP:0004368)2.06099086
95Hyperuricemia (HP:0002149)2.06099086
96Vomiting (HP:0002013)2.05939954
97Cholelithiasis (HP:0001081)2.05374010
98Reduced antithrombin III activity (HP:0001976)2.04548278
99Pancreatitis (HP:0001733)2.04518608
100Cerebral edema (HP:0002181)2.02947194
101Late onset (HP:0003584)2.02099723
102Neonatal onset (HP:0003623)2.01979780
103Acanthocytosis (HP:0001927)2.01971714
104Abnormality of urine glucose concentration (HP:0011016)2.01824302
105Glycosuria (HP:0003076)2.01824302
106Mucopolysacchariduria (HP:0008155)2.01779249
107Urinary glycosaminoglycan excretion (HP:0003541)2.01779249
108Osteomalacia (HP:0002749)2.01420619
109Rickets (HP:0002748)2.01406288
110Cortical dysplasia (HP:0002539)2.01205390
111Nephritis (HP:0000123)2.01156911
112Amyloidosis (HP:0011034)2.01006798
113Abnormality of vitamin metabolism (HP:0100508)1.99013412
114Abnormal enzyme/coenzyme activity (HP:0012379)1.98802721
115Abnormality of carpal bone ossification (HP:0006257)1.96581650
116Absent/shortened dynein arms (HP:0200106)1.95139274
117Dynein arm defect of respiratory motile cilia (HP:0012255)1.95139274
118Premature rupture of membranes (HP:0001788)1.93265349
119Hypochromic microcytic anemia (HP:0004840)1.93067747
120Thrombophlebitis (HP:0004418)1.91915529
121Metaphyseal irregularity (HP:0003025)1.91774288
122Increased neuronal autofluorescent lipopigment (HP:0002074)1.89248820
123Abnormality of polysaccharide metabolism (HP:0011012)1.87013968
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87013968
125Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87013968
126Ileus (HP:0002595)1.86634287
127Opisthotonus (HP:0002179)1.85727849
128Hypophosphatemic rickets (HP:0004912)1.85123697
129Gingival bleeding (HP:0000225)1.83363077
130Elevated alkaline phosphatase (HP:0003155)1.81573164
131Patchy hypopigmentation of hair (HP:0011365)1.78424057
132Axonal loss (HP:0003447)1.77977409
133Enlarged kidneys (HP:0000105)1.77603608
134Tetraparesis (HP:0002273)1.76504801
135Abnormality of alkaline phosphatase activity (HP:0004379)1.76258076
136Polycythemia (HP:0001901)1.75813840
137Beaking of vertebral bodies (HP:0004568)1.75498568
138Abnormality of the gallbladder (HP:0005264)1.75398654
139Symptomatic seizures (HP:0011145)1.71846719
140Abnormal tarsal ossification (HP:0008369)1.70880860
141Dysostosis multiplex (HP:0000943)1.70133774
142Protuberant abdomen (HP:0001538)1.68688509
143Megaloblastic anemia (HP:0001889)1.68130350
144Bifid scrotum (HP:0000048)1.66099969
145Poor head control (HP:0002421)1.65529231
146Right ventricular cardiomyopathy (HP:0011663)1.59727976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK197.09909670
2ERN14.25727074
3MAP3K103.88901014
4BCKDK3.87903061
5EIF2AK13.82708475
6TTK2.92607714
7FGFR42.92337370
8EIF2AK32.87816022
9NEK12.65049003
10SIK12.64142523
11TAOK32.33984705
12TSSK62.27246969
13MST1R2.23654230
14MAP2K32.20039187
15LMTK22.03190916
16EPHB21.98185019
17LATS11.92050734
18FRK1.75058505
19WEE11.75039302
20ERBB41.72796141
21SRPK11.65335731
22KDR1.65076316
23EPHA31.62404065
24BUB11.61451165
25MAP3K31.57625728
26PTK61.51692243
27TYK21.50559994
28TRIB31.47781411
29PKN21.46101492
30NEK91.45523501
31INSRR1.44541704
32STK391.39011355
33FLT31.38063347
34NME21.33744419
35TBK11.33632596
36MET1.31300324
37PLK31.29822333
38ACVR1B1.27360825
39MAP3K141.20980068
40RIPK11.18362422
41ABL21.17235671
42PIK3CG1.16908013
43IRAK31.13874087
44PDGFRA1.12978059
45MAP2K41.07577159
46EEF2K1.05814293
47STK241.05463782
48ERBB21.00484620
49GRK10.99151474
50MAPK110.98272905
51TAF10.94962967
52STK160.92962627
53CAMK1G0.92448481
54SCYL20.92432486
55PLK40.91823326
56STK40.91498856
57TGFBR20.88136762
58LRRK20.88075390
59STK38L0.87537120
60EPHA20.87258625
61PRKG20.86678248
62CDK60.85848938
63FGFR10.85405445
64DDR20.83799202
65NME10.83414149
66IRAK10.82365354
67MKNK10.82120923
68STK100.81513827
69EPHB10.81262824
70MAP2K60.81249746
71PBK0.80971914
72PLK10.80781971
73SMG10.80475025
74JAK20.79915017
75ICK0.79579941
76MAP3K120.77679004
77PNCK0.76531238
78MKNK20.76026555
79PRKAA20.75047280
80CDK70.74096604
81MAP3K80.73778224
82MATK0.73238027
83MAP2K10.72618770
84BMPR1B0.70305483
85JAK10.68668635
86MAPK120.68233181
87BRSK10.68086406
88TRIM280.67977534
89TIE10.66426368
90GRK70.65994101
91MAPK40.63511781
92NEK20.62936237
93WNK40.62473480
94PLK20.60803379
95ALK0.60179438
96MAPKAPK30.59987180
97CDC70.59039191
98GSK3A0.58255860
99PTK20.57393351
100CSK0.56807874
101NEK60.56736790
102YES10.55431644
103MST40.55222464
104MELK0.54566019
105MYLK0.53943584
106MAP3K20.53808688
107TLK10.53194048
108ZAP700.51280784
109STK30.50966663
110CHUK0.50897731
111FGFR20.50414255
112PAK20.49934406
113TGFBR10.49822596
114PIM20.48093979
115VRK20.48040942
116CDK120.47975586
117IKBKE0.47684622
118PRKACG0.47223914
119WNK30.46076908
120BRSK20.45476096
121CSNK1E0.45241065
122IGF1R0.45166217
123CHEK20.44028006
124CDK40.43585212
125DYRK1B0.42784575
126TESK10.42733328
127BMX0.42556686
128GRK60.42225275
129MAP3K110.41235529
130AURKB0.40864172
131FGFR30.40827912
132EIF2AK20.40538553
133MAP3K90.40271330
134EGFR0.39649815
135CSNK2A10.39472571
136PDK20.39345362
137CSNK1G10.38393805
138BLK0.37570662
139NTRK10.36603278
140MAP2K20.35596166
141AKT30.35310545
142IKBKB0.34662784
143OXSR10.34429129
144AKT20.34169871
145PAK40.33973092
146PRKCZ0.32471915
147NUAK10.32065720
148PRKAA10.31859745
149FER0.31733406
150ATM0.31269447
151CSNK1G30.30530727
152CSF1R0.28902615
153CAMK1D0.26989795
154LATS20.26930559
155MAPK150.26272199
156MTOR0.25053447

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.92107137
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.51846793
3Nitrogen metabolism_Homo sapiens_hsa009102.86676415
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70431844
5Tryptophan metabolism_Homo sapiens_hsa003802.69077409
6Arginine biosynthesis_Homo sapiens_hsa002202.65102995
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62966014
8Complement and coagulation cascades_Homo sapiens_hsa046102.56262794
9Fatty acid degradation_Homo sapiens_hsa000712.45065878
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39891952
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.38511466
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38173775
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32178861
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25433815
15Histidine metabolism_Homo sapiens_hsa003402.12060960
16Chemical carcinogenesis_Homo sapiens_hsa052042.06570638
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05755170
18Peroxisome_Homo sapiens_hsa041462.00958780
19Butanoate metabolism_Homo sapiens_hsa006501.93942629
20beta-Alanine metabolism_Homo sapiens_hsa004101.93325099
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.92288175
22Caffeine metabolism_Homo sapiens_hsa002321.90474621
23Staphylococcus aureus infection_Homo sapiens_hsa051501.89523239
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.86606929
25Propanoate metabolism_Homo sapiens_hsa006401.81254743
26Phenylalanine metabolism_Homo sapiens_hsa003601.80874280
27PPAR signaling pathway_Homo sapiens_hsa033201.79387502
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.75535308
29Tyrosine metabolism_Homo sapiens_hsa003501.69734458
30Fatty acid metabolism_Homo sapiens_hsa012121.68433569
31Retinol metabolism_Homo sapiens_hsa008301.65280650
32Sulfur metabolism_Homo sapiens_hsa009201.61187388
33Bile secretion_Homo sapiens_hsa049761.55746464
34Starch and sucrose metabolism_Homo sapiens_hsa005001.48393259
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45353881
36Selenocompound metabolism_Homo sapiens_hsa004501.43741413
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41080104
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36141123
39Fat digestion and absorption_Homo sapiens_hsa049751.35383106
40Pyruvate metabolism_Homo sapiens_hsa006201.29338134
41Folate biosynthesis_Homo sapiens_hsa007901.29031070
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27996803
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27787999
44Steroid biosynthesis_Homo sapiens_hsa001001.27565769
45Vitamin digestion and absorption_Homo sapiens_hsa049771.19454197
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16343806
47Carbon metabolism_Homo sapiens_hsa012001.10772528
48ABC transporters_Homo sapiens_hsa020101.09703874
49Fatty acid elongation_Homo sapiens_hsa000621.09111347
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08600569
51Arginine and proline metabolism_Homo sapiens_hsa003301.07548178
52Biosynthesis of amino acids_Homo sapiens_hsa012301.04553491
53Proteasome_Homo sapiens_hsa030501.03414822
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.02721219
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.00758165
56Sphingolipid metabolism_Homo sapiens_hsa006000.99223978
57Renin-angiotensin system_Homo sapiens_hsa046140.98629274
58Glutathione metabolism_Homo sapiens_hsa004800.97242819
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.96537356
60Sulfur relay system_Homo sapiens_hsa041220.95489868
61Protein export_Homo sapiens_hsa030600.88190355
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84746489
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82764984
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82160689
65N-Glycan biosynthesis_Homo sapiens_hsa005100.78254897
66Lysine degradation_Homo sapiens_hsa003100.70826015
67Glycerolipid metabolism_Homo sapiens_hsa005610.68988652
68One carbon pool by folate_Homo sapiens_hsa006700.68422686
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67373201
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66287181
71African trypanosomiasis_Homo sapiens_hsa051430.65822630
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64484464
73Pentose phosphate pathway_Homo sapiens_hsa000300.63867161
74Non-homologous end-joining_Homo sapiens_hsa034500.59003703
75Vibrio cholerae infection_Homo sapiens_hsa051100.55286619
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52352001
77Galactose metabolism_Homo sapiens_hsa000520.52279443
78Mismatch repair_Homo sapiens_hsa034300.47003419
79Vitamin B6 metabolism_Homo sapiens_hsa007500.46817356
80Metabolic pathways_Homo sapiens_hsa011000.43662411
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42617060
82* Mineral absorption_Homo sapiens_hsa049780.34401632
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33481354
84Fructose and mannose metabolism_Homo sapiens_hsa000510.31172964
85Prion diseases_Homo sapiens_hsa050200.30213039
86Nucleotide excision repair_Homo sapiens_hsa034200.30162988
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27555846
88Linoleic acid metabolism_Homo sapiens_hsa005910.26248758
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.26152340
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25545646
91RNA transport_Homo sapiens_hsa030130.25305606
92Insulin resistance_Homo sapiens_hsa049310.24576075
93DNA replication_Homo sapiens_hsa030300.24230951
94RNA polymerase_Homo sapiens_hsa030200.23330588
95Thyroid cancer_Homo sapiens_hsa052160.22159482
96Collecting duct acid secretion_Homo sapiens_hsa049660.19864521
97Pyrimidine metabolism_Homo sapiens_hsa002400.19790940
98Adherens junction_Homo sapiens_hsa045200.18257126
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.17440901
100Legionellosis_Homo sapiens_hsa051340.17185581
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17059288
102Lysosome_Homo sapiens_hsa041420.13106228
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11495254
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.08790475
105Protein digestion and absorption_Homo sapiens_hsa049740.08120198
106Pertussis_Homo sapiens_hsa051330.07198939
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.06602743
108Malaria_Homo sapiens_hsa051440.04711605
109Arachidonic acid metabolism_Homo sapiens_hsa005900.04340464
110Hepatitis C_Homo sapiens_hsa051600.03497467
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02056535
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1017941
113Glucagon signaling pathway_Homo sapiens_hsa04922-0.0755368
114AMPK signaling pathway_Homo sapiens_hsa04152-0.0659864
115Leishmaniasis_Homo sapiens_hsa05140-0.0643610
116Graft-versus-host disease_Homo sapiens_hsa05332-0.0410507
117Amoebiasis_Homo sapiens_hsa05146-0.0283348
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0228821
119Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0219869
120Other glycan degradation_Homo sapiens_hsa00511-0.0198123
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0184353

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