SLC33A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.46392847
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.46392847
3L-phenylalanine metabolic process (GO:0006558)6.11737745
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11737745
5aromatic amino acid family catabolic process (GO:0009074)5.45072091
6cysteine metabolic process (GO:0006534)4.85546898
7COPI coating of Golgi vesicle (GO:0048205)4.75183269
8Golgi transport vesicle coating (GO:0048200)4.75183269
9behavioral response to nicotine (GO:0035095)4.73712209
10sulfur amino acid catabolic process (GO:0000098)4.70768282
11L-fucose catabolic process (GO:0042355)4.56815138
12fucose catabolic process (GO:0019317)4.56815138
13L-fucose metabolic process (GO:0042354)4.56815138
14alpha-linolenic acid metabolic process (GO:0036109)4.56664948
15indole-containing compound catabolic process (GO:0042436)4.55957080
16indolalkylamine catabolic process (GO:0046218)4.55957080
17tryptophan catabolic process (GO:0006569)4.55957080
18glyoxylate metabolic process (GO:0046487)4.51388687
19tryptophan metabolic process (GO:0006568)4.49387188
20bile acid biosynthetic process (GO:0006699)4.42747634
21lysine metabolic process (GO:0006553)4.42271662
22lysine catabolic process (GO:0006554)4.42271662
23kynurenine metabolic process (GO:0070189)4.41880615
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35342223
25drug transmembrane transport (GO:0006855)4.31085921
26homocysteine metabolic process (GO:0050667)4.23020176
27peptidyl-glutamic acid carboxylation (GO:0017187)4.14493989
28protein carboxylation (GO:0018214)4.14493989
29signal peptide processing (GO:0006465)4.13730544
30exogenous drug catabolic process (GO:0042738)4.10475805
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05828719
32cellular modified amino acid catabolic process (GO:0042219)4.01275941
33aromatic amino acid family metabolic process (GO:0009072)3.96439807
34urea cycle (GO:0000050)3.93259808
35urea metabolic process (GO:0019627)3.93259808
36high-density lipoprotein particle remodeling (GO:0034375)3.91565480
37tyrosine metabolic process (GO:0006570)3.91209048
38bile acid metabolic process (GO:0008206)3.87283758
39complement activation, alternative pathway (GO:0006957)3.86526043
40short-chain fatty acid metabolic process (GO:0046459)3.81366180
41COPII vesicle coating (GO:0048208)3.80301271
42water-soluble vitamin biosynthetic process (GO:0042364)3.78250359
43negative regulation of fibrinolysis (GO:0051918)3.77572313
44valine metabolic process (GO:0006573)3.75660670
45intestinal cholesterol absorption (GO:0030299)3.75067484
46oxidative demethylation (GO:0070989)3.74863988
47regulation of protein activation cascade (GO:2000257)3.70694922
48nitrogen cycle metabolic process (GO:0071941)3.70589314
49serine family amino acid catabolic process (GO:0009071)3.70453694
50reverse cholesterol transport (GO:0043691)3.70044710
51alpha-amino acid catabolic process (GO:1901606)3.65611928
52regulation of cholesterol homeostasis (GO:2000188)3.63635065
53glutamate metabolic process (GO:0006536)3.62794121
54regulation of fibrinolysis (GO:0051917)3.62345326
55amino-acid betaine metabolic process (GO:0006577)3.61807587
56urate metabolic process (GO:0046415)3.56100758
57cellular amino acid catabolic process (GO:0009063)3.55116773
58maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53455106
59coenzyme catabolic process (GO:0009109)3.53188746
60indolalkylamine metabolic process (GO:0006586)3.49652810
61regulation of complement activation (GO:0030449)3.48899445
62glycine transport (GO:0015816)3.47459681
63regulation of triglyceride catabolic process (GO:0010896)3.46361893
64plasma lipoprotein particle remodeling (GO:0034369)3.43744883
65protein-lipid complex remodeling (GO:0034368)3.43744883
66macromolecular complex remodeling (GO:0034367)3.43744883
67triglyceride homeostasis (GO:0070328)3.42099653
68acylglycerol homeostasis (GO:0055090)3.42099653
69drug transport (GO:0015893)3.41462638
70drug catabolic process (GO:0042737)3.37024120
71cellular ketone body metabolic process (GO:0046950)3.36933149
72bile acid and bile salt transport (GO:0015721)3.33082460
73negative regulation of cholesterol transport (GO:0032375)3.32681052
74negative regulation of sterol transport (GO:0032372)3.32681052
75regulation of cholesterol esterification (GO:0010872)3.30305669
764-hydroxyproline metabolic process (GO:0019471)3.29850189
77phospholipid efflux (GO:0033700)3.29702918
78aspartate family amino acid catabolic process (GO:0009068)3.28575983
79regulation of glucokinase activity (GO:0033131)3.27904068
80regulation of hexokinase activity (GO:1903299)3.27904068
81plasma lipoprotein particle clearance (GO:0034381)3.25279932
822-oxoglutarate metabolic process (GO:0006103)3.24264618
83fatty acid oxidation (GO:0019395)3.23628359
84fatty acid beta-oxidation (GO:0006635)3.22766743
85tricarboxylic acid metabolic process (GO:0072350)3.20515245
86S-adenosylmethionine metabolic process (GO:0046500)3.19867750
87lipid oxidation (GO:0034440)3.18777236
88gamma-aminobutyric acid transport (GO:0015812)3.17710708
89cellular glucuronidation (GO:0052695)3.17599938
90regulation of hippo signaling (GO:0035330)3.17422536
91serine family amino acid metabolic process (GO:0009069)3.17391254
92sulfation (GO:0051923)3.16269870
93carboxylic acid catabolic process (GO:0046395)3.16172217
94organic acid catabolic process (GO:0016054)3.16172217
95benzene-containing compound metabolic process (GO:0042537)3.15865086
96protein retention in ER lumen (GO:0006621)3.14442925
97dicarboxylic acid biosynthetic process (GO:0043650)3.12182547
98macroautophagy (GO:0016236)3.11126011
99cholesterol efflux (GO:0033344)3.10173132
100fatty acid catabolic process (GO:0009062)3.09946446
101acetyl-CoA metabolic process (GO:0006084)3.09090650
102monocarboxylic acid catabolic process (GO:0072329)3.08178003
103endocrine pancreas development (GO:0031018)3.07372966
104response to pheromone (GO:0019236)3.06568560
105fucosylation (GO:0036065)3.06052308
106aldehyde catabolic process (GO:0046185)3.03848278
107phospholipid homeostasis (GO:0055091)3.03236673
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00942454
109intestinal absorption (GO:0050892)3.00722096
110nonmotile primary cilium assembly (GO:0035058)2.99734433
111ethanol oxidation (GO:0006069)2.99692323
112cellular biogenic amine catabolic process (GO:0042402)2.97293930
113amine catabolic process (GO:0009310)2.97293930
114lipoprotein metabolic process (GO:0042157)2.97157584
115nephron tubule morphogenesis (GO:0072078)2.96606363
116nephron epithelium morphogenesis (GO:0072088)2.96606363
117regulation of cholesterol biosynthetic process (GO:0045540)2.96546396
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95979684
119plasma lipoprotein particle assembly (GO:0034377)2.95515506
120branched-chain amino acid metabolic process (GO:0009081)2.94988777
121ketone body metabolic process (GO:1902224)2.94135611
122glucuronate metabolic process (GO:0019585)2.92354855
123iron ion import (GO:0097286)2.90892719
124detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88503259
125rRNA catabolic process (GO:0016075)2.88073909
126indole-containing compound metabolic process (GO:0042430)2.87095084
127protein import into peroxisome matrix (GO:0016558)2.84556729
128detection of light stimulus involved in sensory perception (GO:0050962)2.83686771
129detection of light stimulus involved in visual perception (GO:0050908)2.83686771
130organic cation transport (GO:0015695)2.83019530
131dopamine transport (GO:0015872)2.81403798
132kidney morphogenesis (GO:0060993)2.78442121
133arginine metabolic process (GO:0006525)2.75843235
134reflex (GO:0060004)2.75142279
135magnesium ion transport (GO:0015693)2.73618793
136retinal metabolic process (GO:0042574)2.72586221
137protein K11-linked deubiquitination (GO:0035871)2.70158275
138positive regulation of glycolytic process (GO:0045821)2.64403665
139preassembly of GPI anchor in ER membrane (GO:0016254)2.61857678
140neural tube formation (GO:0001841)2.59779304
141epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.57211370
142primary amino compound metabolic process (GO:1901160)2.53917736
143thyroid hormone metabolic process (GO:0042403)2.53792603
144zinc ion homeostasis (GO:0055069)2.52547282
145nucleotide transmembrane transport (GO:1901679)2.50611899
146adaptation of signaling pathway (GO:0023058)2.49990477
147auditory receptor cell differentiation (GO:0042491)2.48221624
148replicative senescence (GO:0090399)2.46942657
149purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.46089605
1503-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.46089605
151phasic smooth muscle contraction (GO:0014821)2.46005408
152regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.45040564
153cilium morphogenesis (GO:0060271)2.44997815
154positive regulation of fatty acid oxidation (GO:0046321)2.44569611
155establishment of protein localization to Golgi (GO:0072600)2.44456544
156endosome to melanosome transport (GO:0035646)2.43291735
157endosome to pigment granule transport (GO:0043485)2.43291735
158reciprocal DNA recombination (GO:0035825)2.41801415
159reciprocal meiotic recombination (GO:0007131)2.41801415
160retinal cone cell development (GO:0046549)2.40392221
161flavonoid metabolic process (GO:0009812)2.39937438
162fucose metabolic process (GO:0006004)2.38115191
163uronic acid metabolic process (GO:0006063)2.38027097
164renal tubule morphogenesis (GO:0061333)2.36994416
165positive regulation of fatty acid beta-oxidation (GO:0032000)2.36605270
166alkaloid metabolic process (GO:0009820)2.36434710
167fatty acid transmembrane transport (GO:1902001)2.36118691
168cellular response to exogenous dsRNA (GO:0071360)2.33521607
169photoreceptor cell development (GO:0042461)2.32408171
170negative regulation of systemic arterial blood pressure (GO:0003085)2.32305923
171peristalsis (GO:0030432)2.32011626
172mannosylation (GO:0097502)2.31904040
173DNA deamination (GO:0045006)2.30140007
174cAMP catabolic process (GO:0006198)2.29597796
175cellular response to ethanol (GO:0071361)2.28391438
176parturition (GO:0007567)2.28164552
177positive regulation of fatty acid transport (GO:2000193)2.27921797
178piRNA metabolic process (GO:0034587)2.27290251

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.87670454
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.58522240
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.63651419
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.38237991
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.67801305
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.19324528
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.11765630
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63607133
9ZNF274_21170338_ChIP-Seq_K562_Hela3.52113430
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.34152094
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.28720110
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.21912523
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.92388156
14GBX2_23144817_ChIP-Seq_PC3_Human2.89064737
15VDR_22108803_ChIP-Seq_LS180_Human2.86713744
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71015940
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63232275
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.50136175
19GATA1_22025678_ChIP-Seq_K562_Human2.31337074
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.24414077
21IGF1R_20145208_ChIP-Seq_DFB_Human2.20843342
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15136216
23EWS_26573619_Chip-Seq_HEK293_Human2.12764821
24TAF15_26573619_Chip-Seq_HEK293_Human2.11482199
25PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10006113
26FUS_26573619_Chip-Seq_HEK293_Human2.08893829
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.06605279
28CLOCK_20551151_ChIP-Seq_293T_Human2.06459209
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98761288
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96095251
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.93118269
32ER_23166858_ChIP-Seq_MCF-7_Human1.92210940
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86143108
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81130684
35P300_19829295_ChIP-Seq_ESCs_Human1.80394024
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.80175682
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78310048
38STAT3_23295773_ChIP-Seq_U87_Human1.74781574
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74643788
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72426324
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.72206699
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67219409
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65767362
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63884796
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58923918
46SMAD4_21799915_ChIP-Seq_A2780_Human1.57127094
47TP53_16413492_ChIP-PET_HCT116_Human1.54164602
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53827855
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53219871
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.52085741
51* TCF4_23295773_ChIP-Seq_U87_Human1.50275589
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49274118
53CBP_20019798_ChIP-Seq_JUKART_Human1.48475668
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48475668
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46921743
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46809630
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44885955
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.44204151
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.42974953
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.40739837
61AR_25329375_ChIP-Seq_VCAP_Human1.40066746
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39980588
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39350027
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36872318
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36803652
66TCF4_22108803_ChIP-Seq_LS180_Human1.36382349
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35026482
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34838407
69TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32020596
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30517351
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.30253369
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.29431400
73IRF1_19129219_ChIP-ChIP_H3396_Human1.28149241
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.27905117
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.27696823
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26274111
77GATA4_25053715_ChIP-Seq_YYC3_Human1.26228053
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24779858
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24779858
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24074982
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.23659140
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23364536
83AR_21572438_ChIP-Seq_LNCaP_Human1.23339796
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22897906
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22595399
86AHR_22903824_ChIP-Seq_MCF-7_Human1.21574946
87SOX2_19829295_ChIP-Seq_ESCs_Human1.21317129
88NANOG_19829295_ChIP-Seq_ESCs_Human1.21317129
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21252262
90EZH2_22144423_ChIP-Seq_EOC_Human1.20100631
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.18729294
92P53_22387025_ChIP-Seq_ESCs_Mouse1.18682219
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.18279491
94RUNX2_22187159_ChIP-Seq_PCA_Human1.18213686
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17071448
96HTT_18923047_ChIP-ChIP_STHdh_Human1.16232897
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.15043994
98TP53_22573176_ChIP-Seq_HFKS_Human1.11649724
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.11511626
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11511626
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10956420
102E2F1_18555785_Chip-Seq_ESCs_Mouse1.10434655
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.10051829
104FOXA1_25552417_ChIP-Seq_VCAP_Human1.09197211
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08074130
106SOX2_20726797_ChIP-Seq_SW620_Human1.06982390
107TRIM28_21343339_ChIP-Seq_HEK293_Human1.06112578
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.06106493
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06032399
110JUN_21703547_ChIP-Seq_K562_Human1.05456845
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.04749041
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.03932573
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03152779
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03152779
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03115480
116TP53_18474530_ChIP-ChIP_U2OS_Human1.01830276
117ELK1_19687146_ChIP-ChIP_HELA_Human1.00763081
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00258818
119P300_18555785_Chip-Seq_ESCs_Mouse0.99418422
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.98238695
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98223090
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98138094
123* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90156326
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.89312749
125SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87899197
126ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86480772
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86467610
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85984545
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83439590
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79929221
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.79440844
132GATA6_25053715_ChIP-Seq_YYC3_Human0.78855343
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78684292
134* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78408930
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78061347
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77432090
137TP63_23658742_ChIP-Seq_EP156T_Human0.76117495
138NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75971772
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75105226
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75043973
141SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74162315
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73331298
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72144442
144PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71936552
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.70602935
146NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70016134
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69483225
148CDX2_19796622_ChIP-Seq_MESCs_Mouse0.69253970
149NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.69211575
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.66759086
151GATA1_19941826_ChIP-Seq_K562_Human0.66631577
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66418814
153PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65939559
154BCAT_22108803_ChIP-Seq_LS180_Human0.65005536
155ERG_20517297_ChIP-Seq_VCAP_Human0.64592165
156CDX2_22108803_ChIP-Seq_LS180_Human0.63722722
157SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.63598494
158CBP_21632823_ChIP-Seq_H3396_Human0.63231389
159SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.62222273
160TBX20_22328084_ChIP-Seq_HEART_Mouse0.60526460
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.60526460
162RXRA_24833708_ChIP-Seq_LIVER_Mouse0.60020783
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.58798909
164SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.58486280
165GATA2_21666600_ChIP-Seq_HMVEC_Human0.57026603
166IRF8_27001747_Chip-Seq_BMDM_Mouse0.55723865
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.54977222
168GATA2_19941826_ChIP-Seq_K562_Human0.54136255
169FOXM1_26456572_ChIP-Seq_MCF-7_Human0.53957911
170* AR_20517297_ChIP-Seq_VCAP_Human0.53787804
171RARA_24833708_ChIP-Seq_LIVER_Mouse0.52843927
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.52801385
173RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.51291459
174NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.50935161
175CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.50558436
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.50270141
177GATA3_27048872_Chip-Seq_THYMUS_Human0.50261024
178FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.49351682
179LXR_22292898_ChIP-Seq_THP-1_Human0.48682715
180CJUN_26792858_Chip-Seq_BT549_Human0.47721866
181RACK7_27058665_Chip-Seq_MCF-7_Human0.44910020
182P63_26484246_Chip-Seq_KERATINOCYTES_Human0.44658714
183RXR_22108803_ChIP-Seq_LS180_Human0.44539918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.61451318
2MP0005360_urolithiasis6.04896119
3MP0005365_abnormal_bile_salt5.20592156
4MP0005085_abnormal_gallbladder_physiolo4.77037020
5MP0000569_abnormal_digit_pigmentation4.45232116
6MP0003195_calcinosis3.77468275
7MP0008875_abnormal_xenobiotic_pharmacok3.75956895
8MP0003252_abnormal_bile_duct3.60027427
9MP0004043_abnormal_pH_regulation2.86672875
10MP0005332_abnormal_amino_acid2.86476885
11MP0001666_abnormal_nutrient_absorption2.79874424
12MP0003806_abnormal_nucleotide_metabolis2.74997459
13MP0005083_abnormal_biliary_tract2.73136660
14MP0002138_abnormal_hepatobiliary_system2.70380291
15MP0010329_abnormal_lipoprotein_level2.63270967
16MP0000427_abnormal_hair_cycle2.58555943
17MP0009840_abnormal_foam_cell2.58223976
18MP0000383_abnormal_hair_follicle2.58038370
19MP0004142_abnormal_muscle_tone2.48124791
20MP0003011_delayed_dark_adaptation2.36387008
21MP0005551_abnormal_eye_electrophysiolog2.21951487
22MP0005220_abnormal_exocrine_pancreas2.07941339
23MP0010678_abnormal_skin_adnexa2.07571780
24MP0003868_abnormal_feces_composition2.06207280
25MP0009643_abnormal_urine_homeostasis2.03179341
26MP0006072_abnormal_retinal_apoptosis2.01531800
27MP0004019_abnormal_vitamin_homeostasis1.96289670
28MP0002118_abnormal_lipid_homeostasis1.93319857
29MP0003136_yellow_coat_color1.91417604
30MP0000609_abnormal_liver_physiology1.86480031
31MP0001919_abnormal_reproductive_system1.83389464
32MP0009780_abnormal_chondrocyte_physiolo1.78702858
33MP0003191_abnormal_cellular_cholesterol1.78143817
34MP0001986_abnormal_taste_sensitivity1.76107815
35MP0003646_muscle_fatigue1.74651982
36MP0005389_reproductive_system_phenotype1.73950229
37MP0001944_abnormal_pancreas_morphology1.70610659
38MP0002693_abnormal_pancreas_physiology1.65995936
39MP0002877_abnormal_melanocyte_morpholog1.64808338
40MP0005253_abnormal_eye_physiology1.61419937
41MP0005058_abnormal_lysosome_morphology1.60700456
42MP0003718_maternal_effect1.60007234
43MP0005174_abnormal_tail_pigmentation1.56656298
44MP0005636_abnormal_mineral_homeostasis1.55698837
45MP0002160_abnormal_reproductive_system1.51268521
46MP0005319_abnormal_enzyme/_coenzyme1.50566042
47MP0002078_abnormal_glucose_homeostasis1.50472907
48MP0003183_abnormal_peptide_metabolism1.49268670
49MP0004885_abnormal_endolymph1.49033693
50MP0001765_abnormal_ion_homeostasis1.47939752
51MP0002234_abnormal_pharynx_morphology1.47430788
52MP0003283_abnormal_digestive_organ1.47265265
53MP0008877_abnormal_DNA_methylation1.46874085
54MP0003300_gastrointestinal_ulcer1.44918278
55MP0003950_abnormal_plasma_membrane1.44344606
56MP0002938_white_spotting1.42648348
57MP0002254_reproductive_system_inflammat1.42568883
58MP0004147_increased_porphyrin_level1.42177408
59MP0008872_abnormal_physiological_respon1.39811311
60MP0010234_abnormal_vibrissa_follicle1.37844749
61MP0002102_abnormal_ear_morphology1.37353509
62MP0001764_abnormal_homeostasis1.36794518
63MP0005584_abnormal_enzyme/coenzyme_acti1.34751524
64MP0001756_abnormal_urination1.33940276
65MP0002909_abnormal_adrenal_gland1.33253737
66MP0005379_endocrine/exocrine_gland_phen1.31654687
67MP0000013_abnormal_adipose_tissue1.27605305
68MP0000604_amyloidosis1.26610532
69MP0000372_irregular_coat_pigmentation1.24886919
70MP0008775_abnormal_heart_ventricle1.16896031
71MP0004264_abnormal_extraembryonic_tissu1.16816567
72MP0001324_abnormal_eye_pigmentation1.16096858
73MP0002876_abnormal_thyroid_physiology1.15465722
74MP0005535_abnormal_body_temperature1.13436511
75MP0002928_abnormal_bile_duct1.11958286
76MP0003890_abnormal_embryonic-extraembry1.11257500
77MP0001501_abnormal_sleep_pattern1.10701070
78MP0005408_hypopigmentation1.08973252
79MP0002638_abnormal_pupillary_reflex1.08757498
80MP0003705_abnormal_hypodermis_morpholog1.07747641
81MP0004215_abnormal_myocardial_fiber1.07389997
82MP0005084_abnormal_gallbladder_morpholo1.06913262
83MP0005645_abnormal_hypothalamus_physiol1.06521715
84MP0010386_abnormal_urinary_bladder1.04604131
85MP0003172_abnormal_lysosome_physiology1.04121805
86MP0005395_other_phenotype1.02083500
87MP0003329_amyloid_beta_deposits1.01420081
88MP0009046_muscle_twitch0.99359295
89MP0003186_abnormal_redox_activity0.97104097
90MP0000647_abnormal_sebaceous_gland0.96059666
91MP0000598_abnormal_liver_morphology0.95053248
92MP0009642_abnormal_blood_homeostasis0.94296079
93MP0001661_extended_life_span0.93580690
94MP0000371_diluted_coat_color0.93106418
95MP0004924_abnormal_behavior0.92927774
96MP0005386_behavior/neurological_phenoty0.92927774
97MP0004133_heterotaxia0.91302711
98MP0002837_dystrophic_cardiac_calcinosis0.89049639
99MP0002272_abnormal_nervous_system0.88220059
100MP0008469_abnormal_protein_level0.87104249
101MP0005195_abnormal_posterior_eye0.86788516
102MP0005646_abnormal_pituitary_gland0.85939005
103MP0002136_abnormal_kidney_physiology0.84991284
104MP0000631_abnormal_neuroendocrine_gland0.84775505
105MP0003959_abnormal_lean_body0.84326801
106MP0003045_fibrosis0.84315185
107MP0005503_abnormal_tendon_morphology0.84261229
108MP0003941_abnormal_skin_development0.82944391
109MP0003953_abnormal_hormone_level0.81232672
110MP0005448_abnormal_energy_balance0.79986903
111MP0001873_stomach_inflammation0.78251369
112MP0005647_abnormal_sex_gland0.77959394
113MP0005334_abnormal_fat_pad0.77525996
114MP0002971_abnormal_brown_adipose0.77380968
115MP0002896_abnormal_bone_mineralization0.76399741
116MP0001984_abnormal_olfaction0.76316655
117MP0009764_decreased_sensitivity_to0.74959023
118MP0009384_cardiac_valve_regurgitation0.74071139
119MP0003690_abnormal_glial_cell0.73178513
120MP0003936_abnormal_reproductive_system0.73130427
121MP0001485_abnormal_pinna_reflex0.72166114
122MP0003632_abnormal_nervous_system0.72017909
123MP0005167_abnormal_blood-brain_barrier0.70742275
124MP0005670_abnormal_white_adipose0.70416210
125MP0000579_abnormal_nail_morphology0.70187230
126MP0002098_abnormal_vibrissa_morphology0.70178680
127MP0003656_abnormal_erythrocyte_physiolo0.69875519
128MP0003937_abnormal_limbs/digits/tail_de0.69459123
129MP0000538_abnormal_urinary_bladder0.69342771
130MP0009745_abnormal_behavioral_response0.68613627
131MP0008961_abnormal_basal_metabolism0.68463675
132MP0004134_abnormal_chest_morphology0.68238148
133MP0009763_increased_sensitivity_to0.68216724
134MP0009697_abnormal_copulation0.67963104
135MP0000230_abnormal_systemic_arterial0.67953024
136MP0001968_abnormal_touch/_nociception0.63987115
137MP0009765_abnormal_xenobiotic_induced0.63830959
138MP0000003_abnormal_adipose_tissue0.63593628
139MP0006036_abnormal_mitochondrial_physio0.63355741
140MP0005310_abnormal_salivary_gland0.62763217
141MP0002295_abnormal_pulmonary_circulatio0.62565854
142MP0004130_abnormal_muscle_cell0.62390674
143MP0002168_other_aberrant_phenotype0.62298844
144MP0002166_altered_tumor_susceptibility0.57061986
145MP0000613_abnormal_salivary_gland0.56265128
146MP0000639_abnormal_adrenal_gland0.55939604
147MP0005376_homeostasis/metabolism_phenot0.55048570
148MP0005451_abnormal_body_composition0.53911887
149MP0003075_altered_response_to0.51221097
150MP0003638_abnormal_response/metabolism_0.51153011
151MP0006054_spinal_hemorrhage0.51033647
152MP0005666_abnormal_adipose_tissue0.50355787
153MP0000462_abnormal_digestive_system0.50188287
154MP0001881_abnormal_mammary_gland0.49896207
155MP0005375_adipose_tissue_phenotype0.48265536
156MP0002090_abnormal_vision0.48048077
157MP0001845_abnormal_inflammatory_respons0.43078560
158MP0009053_abnormal_anal_canal0.42474637
159MP0004947_skin_inflammation0.39507338

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.12870039
2Intrahepatic cholestasis (HP:0001406)5.54667084
3Hypoglycemic coma (HP:0001325)5.33511645
4Xanthomatosis (HP:0000991)4.81574102
5Ketoacidosis (HP:0001993)4.70581213
6Deep venous thrombosis (HP:0002625)4.66226354
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.63096867
8Hypoglycemic seizures (HP:0002173)4.58672434
9Ketosis (HP:0001946)4.58383610
10Pancreatic cysts (HP:0001737)4.48986981
11Hyperinsulinemic hypoglycemia (HP:0000825)4.42692373
12Prolonged partial thromboplastin time (HP:0003645)4.28703109
13Hypobetalipoproteinemia (HP:0003563)4.16249147
14Abnormality of the intrinsic pathway (HP:0010989)4.11918034
15Abnormality of the common coagulation pathway (HP:0010990)4.05910181
16Type II lissencephaly (HP:0007260)4.05637250
17Pancreatic fibrosis (HP:0100732)3.98721846
18Molar tooth sign on MRI (HP:0002419)3.94146454
19Abnormality of midbrain morphology (HP:0002418)3.94146454
20Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86436803
21Symptomatic seizures (HP:0011145)3.69712358
22Conjugated hyperbilirubinemia (HP:0002908)3.68228550
23Complement deficiency (HP:0004431)3.68117945
24Hyperglycinuria (HP:0003108)3.66280301
25Gout (HP:0001997)3.62654362
26Hyperlipoproteinemia (HP:0010980)3.60871744
27True hermaphroditism (HP:0010459)3.59676544
28Hyperglycinemia (HP:0002154)3.58681810
29Fat malabsorption (HP:0002630)3.58332357
30Congenital stationary night blindness (HP:0007642)3.57108212
31Fair hair (HP:0002286)3.55197336
32Abnormality of glycine metabolism (HP:0010895)3.53797202
33Abnormality of serine family amino acid metabolism (HP:0010894)3.53797202
34Abnormality of the renal cortex (HP:0011035)3.53521190
35Hyperventilation (HP:0002883)3.51371043
36Tubular atrophy (HP:0000092)3.48619735
37Hyperammonemia (HP:0001987)3.39231686
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.35428058
39Late onset (HP:0003584)3.21932976
40Nephronophthisis (HP:0000090)3.20935253
41Epidermoid cyst (HP:0200040)3.19147801
42Hypolipoproteinemia (HP:0010981)3.18984427
43Abnormality of purine metabolism (HP:0004352)3.18485743
44Abnormality of aspartate family amino acid metabolism (HP:0010899)3.14925180
45Generalized aminoaciduria (HP:0002909)3.06870468
46Large for gestational age (HP:0001520)3.06358384
47Abnormality of the renal medulla (HP:0100957)3.04350389
48Joint hemorrhage (HP:0005261)3.00815428
49Hyperglycemia (HP:0003074)2.96887154
50Abnormal biliary tract physiology (HP:0012439)2.96181284
51Bile duct proliferation (HP:0001408)2.96181284
52Decreased circulating renin level (HP:0003351)2.92587654
53Generalized hypopigmentation of hair (HP:0011358)2.92304587
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.90565093
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.89090932
56Chronic hepatic failure (HP:0100626)2.86892194
57Abnormality of fatty-acid metabolism (HP:0004359)2.86884001
58Abnormality of alanine metabolism (HP:0010916)2.85453956
59Hyperalaninemia (HP:0003348)2.85453956
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.85453956
61Abnormality of methionine metabolism (HP:0010901)2.85260931
62Cerebellar dysplasia (HP:0007033)2.84054943
63Urinary glycosaminoglycan excretion (HP:0003541)2.83105973
64Mucopolysacchariduria (HP:0008155)2.83105973
65Skin nodule (HP:0200036)2.81928972
66Hypoalphalipoproteinemia (HP:0003233)2.78358887
67Abnormality of the pancreatic islet cells (HP:0006476)2.74932624
68Abnormality of endocrine pancreas physiology (HP:0012093)2.74932624
69Concave nail (HP:0001598)2.71627247
70Furrowed tongue (HP:0000221)2.70682970
71Increased corneal curvature (HP:0100692)2.70609240
72Keratoconus (HP:0000563)2.70609240
73Cystic liver disease (HP:0006706)2.67558046
74Abnormality of nucleobase metabolism (HP:0010932)2.66715420
75Abnormality of the pons (HP:0007361)2.65928792
76Steatorrhea (HP:0002570)2.60800338
77Dysostosis multiplex (HP:0000943)2.58648422
78Hydroxyprolinuria (HP:0003080)2.58120277
79Abnormality of proline metabolism (HP:0010907)2.58120277
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56877642
81Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56877642
82Abnormality of polysaccharide metabolism (HP:0011012)2.56877642
83Hyperbilirubinemia (HP:0002904)2.55228580
84Renal cortical cysts (HP:0000803)2.52123464
85Congenital, generalized hypertrichosis (HP:0004540)2.51763462
86Alkalosis (HP:0001948)2.51747812
87Abnormality of complement system (HP:0005339)2.51195131
88Hypoplasia of the pons (HP:0012110)2.47853242
89Medial flaring of the eyebrow (HP:0010747)2.47493539
90Lissencephaly (HP:0001339)2.42402434
91Myocardial infarction (HP:0001658)2.42218960
92Hyperactive renin-angiotensin system (HP:0000841)2.41207253
93Hypokalemic alkalosis (HP:0001949)2.40834300
94Irritability (HP:0000737)2.39107010
95Attenuation of retinal blood vessels (HP:0007843)2.34472017
96Clumsiness (HP:0002312)2.33644036
97Metabolic acidosis (HP:0001942)2.33460718
98Delayed CNS myelination (HP:0002188)2.33026389
99Hepatocellular carcinoma (HP:0001402)2.32860162
100Progressive inability to walk (HP:0002505)2.30921016
101Pancreatitis (HP:0001733)2.30651353
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.30328285
103Hypercholesterolemia (HP:0003124)2.27041564
104Inability to walk (HP:0002540)2.25762139
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.25320000
106Abnormal drinking behavior (HP:0030082)2.24651179
107Polydipsia (HP:0001959)2.24651179
108Gaze-evoked nystagmus (HP:0000640)2.24253066
109Congenital hepatic fibrosis (HP:0002612)2.23123400
110Dicarboxylic aciduria (HP:0003215)2.22684774
111Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22684774
112Proximal tubulopathy (HP:0000114)2.22457745
113Pancreatic islet-cell hyperplasia (HP:0004510)2.21894354
114Abnormal enzyme/coenzyme activity (HP:0012379)2.20808868
115Chorioretinal atrophy (HP:0000533)2.20394722
116Vacuolated lymphocytes (HP:0001922)2.20194178
117Abolished electroretinogram (ERG) (HP:0000550)2.19243597
118Sensorimotor neuropathy (HP:0007141)2.18238453
119Glycosuria (HP:0003076)2.15855622
120Abnormality of urine glucose concentration (HP:0011016)2.15855622
121Increased purine levels (HP:0004368)2.14949465
122Hyperuricemia (HP:0002149)2.14949465
123Protuberant abdomen (HP:0001538)2.14421139
124Abnormality of serum amino acid levels (HP:0003112)2.12459054
125Tachypnea (HP:0002789)2.12066556
126Pendular nystagmus (HP:0012043)2.11749324
127Elevated alkaline phosphatase (HP:0003155)2.10395581
128Protruding tongue (HP:0010808)2.10377148
129Aplasia/hypoplasia of the uterus (HP:0008684)2.09479817
130Increased circulating renin level (HP:0000848)2.09087062
131Hypoplastic labia majora (HP:0000059)2.07460990
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07274942
133Abnormality of alkaline phosphatase activity (HP:0004379)2.06178643
134Hypothermia (HP:0002045)2.04535022
135Vascular calcification (HP:0004934)2.00211982
136Nephrogenic diabetes insipidus (HP:0009806)1.99942095
137Acute hepatic failure (HP:0006554)1.98853826
138Hypoplasia of the uterus (HP:0000013)1.98801573
139Retinal atrophy (HP:0001105)1.96604379
140Widely spaced teeth (HP:0000687)1.96497413
141Congenital primary aphakia (HP:0007707)1.96264009
142Gait imbalance (HP:0002141)1.95601656
143Insulin-resistant diabetes mellitus (HP:0000831)1.93898245
144Lethargy (HP:0001254)1.93420534
145Mitral stenosis (HP:0001718)1.91819248
146Malnutrition (HP:0004395)1.91231816
147Hypophosphatemia (HP:0002148)1.90224887
148Abnormality of the labia majora (HP:0012881)1.88199992
149Spastic diplegia (HP:0001264)1.86951814
150Abnormality of chloride homeostasis (HP:0011422)1.85286516
151Abdominal distention (HP:0003270)1.85196083
152Esophageal varix (HP:0002040)1.84464273
153Back pain (HP:0003418)1.84380902
154Stomach cancer (HP:0012126)1.84207364
155Hypokalemia (HP:0002900)1.83440141
156Systemic lupus erythematosus (HP:0002725)1.82843268
157Cardiovascular calcification (HP:0011915)1.81353277
158Enlarged kidneys (HP:0000105)1.80762448
159Sclerocornea (HP:0000647)1.80663680
160Insulin resistance (HP:0000855)1.80194433
161Abnormality of renin-angiotensin system (HP:0000847)1.79831588
162Severe muscular hypotonia (HP:0006829)1.78516529
163Pachygyria (HP:0001302)1.77016739
164Barrel-shaped chest (HP:0001552)1.74687158
165Arthropathy (HP:0003040)1.74138479
166Male pseudohermaphroditism (HP:0000037)1.72428945
167Hypoalbuminemia (HP:0003073)1.70634397
168Abnormal albumin level (HP:0012116)1.70634397
169Amelogenesis imperfecta (HP:0000705)1.69903551
170Anencephaly (HP:0002323)1.69659860
171Partial agenesis of the corpus callosum (HP:0001338)1.68339404
172Disproportionate short-trunk short stature (HP:0003521)1.68286275
173Postaxial foot polydactyly (HP:0001830)1.67631537
174Congenital sensorineural hearing impairment (HP:0008527)1.67450829
175Lipid accumulation in hepatocytes (HP:0006561)1.65022671
176Hemiparesis (HP:0001269)1.64533377
177Progressive cerebellar ataxia (HP:0002073)1.63726592
178Abnormal protein N-linked glycosylation (HP:0012347)1.62770327
179Abnormal protein glycosylation (HP:0012346)1.62770327
180Abnormal glycosylation (HP:0012345)1.62770327
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62770327
182Polyuria (HP:0000103)1.62534046
183Abnormality of secondary sexual hair (HP:0009888)1.62233499
184Abnormality of the axillary hair (HP:0100134)1.62233499
185Duplicated collecting system (HP:0000081)1.60660281
186Abnormal rod and cone electroretinograms (HP:0008323)1.58006452
187Genetic anticipation (HP:0003743)1.56961783
188Poor coordination (HP:0002370)1.55868535
189Aplasia/Hypoplasia of the fovea (HP:0008060)1.55733775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.68359513
2BCKDK4.26622893
3TAOK34.08077463
4ERN14.07007674
5FRK3.92994093
6MAP3K23.65310924
7ACVR1B3.38459949
8BMPR1B3.35634196
9TLK12.78292134
10ADRBK22.77220230
11SIK12.56979932
12MAP3K32.52235411
13FGFR42.48779276
14GRK12.47984617
15ZAK2.37822855
16MAPK152.34965238
17WNK42.19155058
18FLT32.12666410
19PASK2.03731331
20TNIK2.03687509
21STK38L1.88211899
22WNK31.85042166
23PINK11.84573936
24TGFBR11.76151386
25TRIB31.75210820
26BRSK21.71911532
27PTK61.60044768
28EPHA31.58498177
29NUAK11.57873980
30CASK1.52977575
31ERBB41.47771416
32MST1R1.45435860
33SCYL21.44957852
34PIK3CG1.31948282
35HIPK21.28404144
36TRPM71.28299233
37MAP3K41.28221986
38MAP3K131.27813538
39MET1.22935433
40TYK21.21024557
41MAPKAPK31.20228288
42JAK11.18945918
43EPHB11.18710742
44JAK21.18591577
45NTRK11.16078790
46PAK31.14902983
47MAP3K141.13107581
48PDGFRA1.11882239
49PIK3CA1.11139912
50MAP4K21.11057585
51ADRBK11.11051440
52OXSR11.10735057
53PRKD31.10212294
54TIE11.09687339
55MAP3K11.08147859
56PKN21.06764432
57IRAK31.03710556
58MAPK131.03097503
59TRIM281.01758060
60ERBB30.99647198
61TBK10.99140365
62DAPK20.98775374
63PTK20.95688523
64IRAK10.94961824
65STK390.94913295
66AKT30.94802523
67STK30.94553087
68STK240.94068790
69JAK30.93684842
70RIPK10.93345692
71PNCK0.92100552
72NEK90.92047965
73LATS10.88630715
74KSR20.86688018
75FGFR30.84377313
76FGFR20.83932181
77MKNK20.83089340
78DYRK1B0.81836128
79TXK0.81187876
80MST40.79417430
81MUSK0.79290938
82FER0.78748765
83MAPKAPK50.78293989
84NTRK30.76012176
85WEE10.75849493
86PRKAA20.74970754
87CAMKK20.74783413
88PRKCG0.73000854
89RET0.72077921
90MAPK110.70701988
91PRKCH0.70304025
92MAP2K20.67300624
93MAP2K60.66711288
94IRAK20.62765668
95GSK3A0.62209060
96PRKAA10.59800669
97RPS6KA50.56099430
98PDPK10.55684094
99CAMK1D0.55134493
100PRKCI0.54032754
101SGK2230.53837689
102SGK4940.53837689
103TEC0.53308159
104BRD40.49509951
105PRKACG0.48715638
106MAP2K40.48096512
107NLK0.47030063
108SGK30.46605595
109MELK0.46464915
110MAP2K70.46251151
111IGF1R0.46229103
112STK380.45297133
113PLK20.44462299
114ABL20.43790881
115BMPR20.43225149
116MAP2K10.41071396
117PRKCZ0.39325155
118WNK10.38475850
119PRKCQ0.37257162
120IKBKE0.37019129
121PRKCE0.36652738
122CSK0.36474556
123PDK30.36275463
124PDK40.36275463
125CSNK1G10.35599297
126MTOR0.35236103
127CAMK2G0.34628940
128IKBKB0.34612030
129ABL10.33996833
130MAP3K70.33810782
131SGK20.32710286
132CSNK1A1L0.31879047
133VRK10.31824141
134RPS6KA60.31742630
135PDK10.31730953
136LMTK20.31600059
137EGFR0.31312896
138EIF2AK30.30695035
139MAP3K90.30210084
140BCR0.29761530
141CSNK1A10.29734969
142CHUK0.29356061
143CAMK1G0.29334141
144STK110.28946909
145PHKG10.28121318
146PHKG20.28121318
147CAMK2A0.27628378
148PRKACA0.26763943
149CAMKK10.26461308
150CDC42BPA0.25339584
151PDGFRB0.24998041
152ERBB20.23911447
153PRKD10.23637267
154ITK0.22875667
155ZAP700.21567642
156PDK20.21559411
157LRRK20.20760831
158IRAK40.19151032
159PRKCA0.19079971

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.77108048
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53431807
3Nitrogen metabolism_Homo sapiens_hsa009103.42798879
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90998143
5Sulfur metabolism_Homo sapiens_hsa009202.74747060
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71471680
7Tryptophan metabolism_Homo sapiens_hsa003802.67330651
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61030269
9Fatty acid degradation_Homo sapiens_hsa000712.42968441
10Arginine biosynthesis_Homo sapiens_hsa002202.38471724
11Butanoate metabolism_Homo sapiens_hsa006502.27465838
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19575865
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03264893
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02644397
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01739656
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00651107
17Complement and coagulation cascades_Homo sapiens_hsa046101.95968864
18Propanoate metabolism_Homo sapiens_hsa006401.94517306
19Selenocompound metabolism_Homo sapiens_hsa004501.90519873
20Peroxisome_Homo sapiens_hsa041461.86756059
21Protein export_Homo sapiens_hsa030601.76127524
22Fatty acid metabolism_Homo sapiens_hsa012121.74433830
23Histidine metabolism_Homo sapiens_hsa003401.70333750
24Ether lipid metabolism_Homo sapiens_hsa005651.69162120
25Phototransduction_Homo sapiens_hsa047441.65035437
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62173268
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60331884
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57188521
29PPAR signaling pathway_Homo sapiens_hsa033201.53084346
30* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50547339
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49520612
32Bile secretion_Homo sapiens_hsa049761.48764161
33Folate biosynthesis_Homo sapiens_hsa007901.44129990
34beta-Alanine metabolism_Homo sapiens_hsa004101.41724150
35Phenylalanine metabolism_Homo sapiens_hsa003601.35533138
36Starch and sucrose metabolism_Homo sapiens_hsa005001.35366962
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31915438
38ABC transporters_Homo sapiens_hsa020101.29456749
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28403006
40Chemical carcinogenesis_Homo sapiens_hsa052041.27609126
41Caffeine metabolism_Homo sapiens_hsa002321.27299644
42Fat digestion and absorption_Homo sapiens_hsa049751.26684245
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23083184
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.21659768
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21550159
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20851022
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18969954
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.18385987
49Pyruvate metabolism_Homo sapiens_hsa006201.17460643
50Mineral absorption_Homo sapiens_hsa049781.14313343
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11112348
52Tyrosine metabolism_Homo sapiens_hsa003501.10965268
53Ovarian steroidogenesis_Homo sapiens_hsa049131.10522195
54Fatty acid elongation_Homo sapiens_hsa000621.09328505
55Arachidonic acid metabolism_Homo sapiens_hsa005901.06962898
56Steroid biosynthesis_Homo sapiens_hsa001001.03389994
57Staphylococcus aureus infection_Homo sapiens_hsa051501.03348202
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02060894
59Basal transcription factors_Homo sapiens_hsa030220.98958755
60Retinol metabolism_Homo sapiens_hsa008300.98508882
61Circadian rhythm_Homo sapiens_hsa047100.93427155
62Homologous recombination_Homo sapiens_hsa034400.92461943
63Vitamin digestion and absorption_Homo sapiens_hsa049770.92091919
64Arginine and proline metabolism_Homo sapiens_hsa003300.91267220
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87844026
66Carbon metabolism_Homo sapiens_hsa012000.84634939
67Fanconi anemia pathway_Homo sapiens_hsa034600.83996744
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82737339
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.79406216
70Lysine degradation_Homo sapiens_hsa003100.77201072
71Biosynthesis of amino acids_Homo sapiens_hsa012300.75553494
72Sphingolipid metabolism_Homo sapiens_hsa006000.72113622
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.71728641
74Lysosome_Homo sapiens_hsa041420.70113570
75RNA degradation_Homo sapiens_hsa030180.68869336
76Nicotine addiction_Homo sapiens_hsa050330.68534296
77Prion diseases_Homo sapiens_hsa050200.67746973
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.66599813
79Sulfur relay system_Homo sapiens_hsa041220.65828014
80Glycerolipid metabolism_Homo sapiens_hsa005610.65572735
81Serotonergic synapse_Homo sapiens_hsa047260.64344810
82Taste transduction_Homo sapiens_hsa047420.63693803
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59008309
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.58885552
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57345558
86Dorso-ventral axis formation_Homo sapiens_hsa043200.55980925
87Insulin resistance_Homo sapiens_hsa049310.55567984
88Fatty acid biosynthesis_Homo sapiens_hsa000610.54322526
89N-Glycan biosynthesis_Homo sapiens_hsa005100.52074183
90TGF-beta signaling pathway_Homo sapiens_hsa043500.51345621
91Other glycan degradation_Homo sapiens_hsa005110.50247285
92Insulin secretion_Homo sapiens_hsa049110.49652094
93Olfactory transduction_Homo sapiens_hsa047400.49237052
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48462757
95Type II diabetes mellitus_Homo sapiens_hsa049300.47923936
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45926698
97RNA polymerase_Homo sapiens_hsa030200.43196289
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42903916
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.42148478
100Galactose metabolism_Homo sapiens_hsa000520.41064413
101Fructose and mannose metabolism_Homo sapiens_hsa000510.40451497
102Thyroid hormone synthesis_Homo sapiens_hsa049180.40360750
103Glutathione metabolism_Homo sapiens_hsa004800.39837537
104Type I diabetes mellitus_Homo sapiens_hsa049400.39831703
105Pancreatic secretion_Homo sapiens_hsa049720.38280347
106Morphine addiction_Homo sapiens_hsa050320.37548595
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36563191
108Vibrio cholerae infection_Homo sapiens_hsa051100.35737537
109* Metabolic pathways_Homo sapiens_hsa011000.35692159
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35347939
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34843815
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33383381
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33370057
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33319748
115Glucagon signaling pathway_Homo sapiens_hsa049220.32620537
116Protein digestion and absorption_Homo sapiens_hsa049740.32383451
117Oxidative phosphorylation_Homo sapiens_hsa001900.30468871
118Vitamin B6 metabolism_Homo sapiens_hsa007500.30239729
119Pentose phosphate pathway_Homo sapiens_hsa000300.29783673
120Renin-angiotensin system_Homo sapiens_hsa046140.29364860
121Glutamatergic synapse_Homo sapiens_hsa047240.27780091
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24408117
123Linoleic acid metabolism_Homo sapiens_hsa005910.22857104
124Regulation of autophagy_Homo sapiens_hsa041400.20275145
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18422153
126AMPK signaling pathway_Homo sapiens_hsa041520.12035190
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.09534213
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09217698
129Cocaine addiction_Homo sapiens_hsa050300.07381139
130One carbon pool by folate_Homo sapiens_hsa006700.07311666

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