SLC34A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)7.26645549
2negative regulation of complement activation (GO:0045916)7.22880930
3cellular response to nitric oxide (GO:0071732)7.01257592
4negative regulation of humoral immune response (GO:0002921)6.91073238
5negative regulation of protein activation cascade (GO:2000258)6.40144893
6response to xenobiotic stimulus (GO:0009410)6.18868872
7positive regulation of endothelial cell differentiation (GO:0045603)6.02196307
8regulation of endothelial cell differentiation (GO:0045601)5.86961844
9peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.82466110
10axonemal dynein complex assembly (GO:0070286)5.75397116
11lung lobe morphogenesis (GO:0060463)5.64799225
12cilium or flagellum-dependent cell motility (GO:0001539)5.46287774
13cellular response to reactive nitrogen species (GO:1902170)5.42778177
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)5.31628684
15one-carbon compound transport (GO:0019755)5.29320747
16endothelial tube morphogenesis (GO:0061154)5.27614592
17morphogenesis of an endothelium (GO:0003159)5.27614592
18positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003605.19036820
19response to nitric oxide (GO:0071731)5.13265768
20regulation of vasculogenesis (GO:2001212)4.71876042
21sodium-independent organic anion transport (GO:0043252)4.59004727
22respiratory gaseous exchange (GO:0007585)4.44438235
23regulation of complement activation (GO:0030449)4.41444141
24regulation of phospholipid biosynthetic process (GO:0071071)4.30682382
25cilium movement (GO:0003341)4.27305430
26peptide catabolic process (GO:0043171)4.25763245
27iron ion import (GO:0097286)4.08956846
28epithelial cell differentiation involved in prostate gland development (GO:0060742)4.06871197
29regulation of protein activation cascade (GO:2000257)4.04638738
30epithelial tube branching involved in lung morphogenesis (GO:0060441)4.02712644
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.01975894
32mesodermal cell differentiation (GO:0048333)4.00685569
33virion attachment to host cell (GO:0019062)4.00027850
34adhesion of symbiont to host cell (GO:0044650)4.00027850
35epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.96735664
36blood vessel maturation (GO:0001955)3.96273809
37sphingosine metabolic process (GO:0006670)3.89890545
38protein localization to endosome (GO:0036010)3.84134920
39lung vasculature development (GO:0060426)3.83967564
40neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.81791712
41hyperosmotic salinity response (GO:0042538)3.71755949
42establishment of apical/basal cell polarity (GO:0035089)3.69831563
43motile cilium assembly (GO:0044458)3.68028632
44hemidesmosome assembly (GO:0031581)3.65696707
45segment specification (GO:0007379)3.64410528
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.64306207
47negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.64123853
48respiratory tube development (GO:0030323)3.60108609
49endocrine hormone secretion (GO:0060986)3.56556098
50positive regulation of p38MAPK cascade (GO:1900745)3.55382585
51lung alveolus development (GO:0048286)3.46869384
52renal absorption (GO:0070293)3.46565228
53sodium ion homeostasis (GO:0055078)3.44279280
54regulation of hippo signaling (GO:0035330)3.42363376
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.41748654
56adhesion of symbiont to host (GO:0044406)3.40841428
57endocardial cushion development (GO:0003197)3.40669292
58diol metabolic process (GO:0034311)3.40618349
59lymphangiogenesis (GO:0001946)3.40582313
60response to vitamin A (GO:0033189)3.39143949
61epithelial cilium movement (GO:0003351)3.30886141
62ethanol metabolic process (GO:0006067)3.30294078
63macrophage chemotaxis (GO:0048246)3.28383107
64ethanol oxidation (GO:0006069)3.27597927
65cell adhesion mediated by integrin (GO:0033627)3.25304052
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.25193725
67calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.24989951
68embryonic foregut morphogenesis (GO:0048617)3.21176158
69complement activation, classical pathway (GO:0006958)3.19948334
70negative regulation of interleukin-2 production (GO:0032703)3.19765754
71angiotensin maturation (GO:0002003)3.19287038
72hormone catabolic process (GO:0042447)3.19036419
73artery development (GO:0060840)3.18788935
74polyol transport (GO:0015791)3.11488893
75establishment or maintenance of monopolar cell polarity (GO:0061339)3.10035136
76establishment of monopolar cell polarity (GO:0061162)3.10035136
77regulation of glomerular filtration (GO:0003093)3.09819517
78regulation of integrin-mediated signaling pathway (GO:2001044)3.09777150
79negative regulation of alcohol biosynthetic process (GO:1902931)3.08979742
80complement activation (GO:0006956)3.08003344
81positive regulation of vasculogenesis (GO:2001214)3.07742014
82glomerular epithelial cell development (GO:0072310)3.03556528
83vascular endothelial growth factor signaling pathway (GO:0038084)3.02694135
84triglyceride biosynthetic process (GO:0019432)3.02227318
85cellular response to thyroid hormone stimulus (GO:0097067)3.00466986
86negative regulation of fatty acid transport (GO:2000192)3.00254092
87response to hyperoxia (GO:0055093)2.99545648
88response to increased oxygen levels (GO:0036296)2.99545648
89fatty-acyl-CoA biosynthetic process (GO:0046949)2.97753577
90regulation of p38MAPK cascade (GO:1900744)2.97484374
91primary alcohol catabolic process (GO:0034310)2.97455623
92negative regulation of transcription by competitive promoter binding (GO:0010944)2.97283103
93import into cell (GO:0098657)2.97229936
94negative regulation of response to reactive oxygen species (GO:1901032)2.96730764
95regulation of cardioblast differentiation (GO:0051890)2.93570002
96branch elongation of an epithelium (GO:0060602)2.93567779
97Leydig cell differentiation (GO:0033327)2.91573155
98axis elongation (GO:0003401)2.90581565
99water homeostasis (GO:0030104)2.90418415
100acylglycerol biosynthetic process (GO:0046463)2.90290692
101neutral lipid biosynthetic process (GO:0046460)2.90290692
102left/right pattern formation (GO:0060972)2.89689866
103regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.88545935
104lung secretory cell differentiation (GO:0061140)2.86935138
105negative regulation of B cell mediated immunity (GO:0002713)2.86615515
106negative regulation of immunoglobulin mediated immune response (GO:0002890)2.86615515
107regulation of interleukin-13 production (GO:0032656)2.85491157
108toxin transport (GO:1901998)2.84549915
109branching involved in salivary gland morphogenesis (GO:0060445)2.83402938
110cellular sodium ion homeostasis (GO:0006883)2.81638626
111negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.81122377
112regulation of humoral immune response (GO:0002920)2.80211272
113cellular response to antibiotic (GO:0071236)2.79403699
114response to interleukin-6 (GO:0070741)2.79364900
115sphingoid metabolic process (GO:0046519)2.78662147
116glomerular filtration (GO:0003094)2.78640407
117lung-associated mesenchyme development (GO:0060484)2.78516364
118branching involved in labyrinthine layer morphogenesis (GO:0060670)2.76866964
119positive regulation of digestive system process (GO:0060456)2.75607755
120tight junction assembly (GO:0070830)2.75258849
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.74811733
122membrane protein proteolysis (GO:0033619)2.73656008
123regulation of apoptotic cell clearance (GO:2000425)2.72858407
124glomerular visceral epithelial cell development (GO:0072015)2.72047041
125protein autoprocessing (GO:0016540)2.71265839
126toxin metabolic process (GO:0009404)2.70834283
127hydrogen peroxide biosynthetic process (GO:0050665)2.70505099
128negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70051562
129multicellular organismal water homeostasis (GO:0050891)2.68620137
130endothelial cell chemotaxis (GO:0035767)2.67926976
131establishment of epithelial cell polarity (GO:0090162)2.67544075
132polarized epithelial cell differentiation (GO:0030859)2.67102538
133renal filtration (GO:0097205)2.65481925
134receptor catabolic process (GO:0032801)2.64664893
135axoneme assembly (GO:0035082)2.64410116
136striated muscle atrophy (GO:0014891)2.63986552
137cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63485426
138retina vasculature morphogenesis in camera-type eye (GO:0061299)2.61998456
139regulation of tight junction assembly (GO:2000810)2.61448094
140regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.60078154
141protein activation cascade (GO:0072376)2.58822409
142thyroid hormone generation (GO:0006590)2.57367545
143coronary vasculature morphogenesis (GO:0060977)2.57356204
144interleukin-6-mediated signaling pathway (GO:0070102)2.56808886
145wound healing, spreading of epidermal cells (GO:0035313)2.56321209
146thioester biosynthetic process (GO:0035384)2.56141835
147complement activation, alternative pathway (GO:0006957)2.53867132
148positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.51620105
149induction of positive chemotaxis (GO:0050930)2.51544689
150negative regulation of stress fiber assembly (GO:0051497)2.50758181
151columnar/cuboidal epithelial cell development (GO:0002066)2.46431880
152neuron remodeling (GO:0016322)2.44026593
153cellular hyperosmotic response (GO:0071474)2.42645080
154positive regulation of chemokine secretion (GO:0090197)2.42581693
155T cell mediated immunity (GO:0002456)2.42182395
156norepinephrine metabolic process (GO:0042415)2.41562798
157peptide cross-linking (GO:0018149)2.40602814
158fibroblast migration (GO:0010761)2.39130306
159phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.37147458
160apoptotic cell clearance (GO:0043277)2.36589391
161lateral ventricle development (GO:0021670)2.36357423
162establishment of endothelial barrier (GO:0061028)2.35973795
163left/right axis specification (GO:0070986)2.35523634
164membrane raft organization (GO:0031579)2.34822428
165surfactant homeostasis (GO:0043129)18.7510576
166chemical homeostasis within a tissue (GO:0048875)15.0169046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.54820740
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.21414198
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18195536
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.00855430
5CLOCK_20551151_ChIP-Seq_293T_Human2.97768802
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.82909391
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72892267
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.70059095
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66791075
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.66201694
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.61218914
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.54663095
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.42684561
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.32797557
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27677251
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24825673
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.14833265
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10421586
19PPAR_26484153_Chip-Seq_NCI-H1993_Human2.09451430
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.06854964
21SOX2_27498859_Chip-Seq_STOMACH_Mouse2.05728222
22SOX2_20726797_ChIP-Seq_SW620_Human2.04503458
23CDX2_20551321_ChIP-Seq_CACO-2_Human2.00326028
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99672320
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95687282
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92719868
27* LXR_22158963_ChIP-Seq_LIVER_Mouse1.91933611
28GATA4_25053715_ChIP-Seq_YYC3_Human1.89331862
29AHR_22903824_ChIP-Seq_MCF-7_Human1.87092525
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.86471114
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85070293
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.82400778
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81300301
34ZNF263_19887448_ChIP-Seq_K562_Human1.77860995
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75391973
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75374324
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71815008
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.71543302
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68978933
40RACK7_27058665_Chip-Seq_MCF-7_Human1.67775828
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66736233
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59971136
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.57393288
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.57393288
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.56831634
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52240165
47* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51919382
48AR_21572438_ChIP-Seq_LNCaP_Human1.50178871
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48723775
50* RXR_22158963_ChIP-Seq_LIVER_Mouse1.46837725
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46317916
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45332563
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.45056697
54CJUN_26792858_Chip-Seq_BT549_Human1.44685264
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43530754
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42966648
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.42709116
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41758702
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.40076237
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.39390116
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36448619
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.36388936
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35719129
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35526269
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.33905988
66GATA6_25053715_ChIP-Seq_YYC3_Human1.30122882
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29642153
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29642153
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29540433
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29122959
71* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28782335
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27917053
73* SMAD3_21741376_ChIP-Seq_HESCs_Human1.27246435
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27048162
75NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25042331
76* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24485456
77KLF5_25053715_ChIP-Seq_YYC3_Human1.24422257
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23848612
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22543918
80KDM2B_26808549_Chip-Seq_K562_Human1.22498586
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21161949
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20434639
83FOXA2_19822575_ChIP-Seq_HepG2_Human1.17914980
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15394278
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15394278
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14850595
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14259651
88ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12001945
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11572856
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10275182
91GATA1_19941826_ChIP-Seq_K562_Human1.09266947
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08110906
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07842194
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07828923
95GATA3_24758297_ChIP-Seq_MCF-7_Human1.07620194
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05926426
97P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04931223
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03918241
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03896187
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03822500
101TP53_18474530_ChIP-ChIP_U2OS_Human1.03804710
102SPI1_23127762_ChIP-Seq_K562_Human1.02225805
103WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02209307
104ISL1_27105846_Chip-Seq_CPCs_Mouse1.01933932
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99884128
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.99733222
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98823075
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.98692157
109CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98612981
110FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97941292
111* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97661000
112JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97496031
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.97051579
114DROSHA_22980978_ChIP-Seq_HELA_Human0.95622875
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95555709
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.93380632
117CREB1_26743006_Chip-Seq_LNCaP_Human0.92011528
118ATF3_27146783_Chip-Seq_COLON_Human0.91900484
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.90229390
120GATA2_19941826_ChIP-Seq_K562_Human0.89407147
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89333574
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89031772
123TP63_23658742_ChIP-Seq_EP156T_Human0.88935120
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87847997
125SMAD4_21799915_ChIP-Seq_A2780_Human0.87274757
126IRF8_22096565_ChIP-ChIP_GC-B_Human0.87061227
127VDR_24787735_ChIP-Seq_THP-1_Human0.86202254
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83672327
129* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82368515
130RXR_22108803_ChIP-Seq_LS180_Human0.75590362
131PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74899425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog9.80031249
2MP0001958_emphysema5.86272023
3MP0008995_early_reproductive_senescence4.76621969
4MP0005083_abnormal_biliary_tract3.98905260
5MP0008004_abnormal_stomach_pH3.68041801
6MP0010368_abnormal_lymphatic_system3.38538277
7MP0002138_abnormal_hepatobiliary_system3.11461598
8MP0001177_atelectasis2.89064993
9MP0003724_increased_susceptibility_to2.87476364
10MP0002133_abnormal_respiratory_system2.78084001
11MP0005388_respiratory_system_phenotype2.78084001
12MP0002295_abnormal_pulmonary_circulatio2.43137951
13MP0010234_abnormal_vibrissa_follicle2.34440513
14MP0005167_abnormal_blood-brain_barrier2.34257733
15MP0003191_abnormal_cellular_cholesterol2.28026625
16MP0000537_abnormal_urethra_morphology2.26160053
17MP0000566_synostosis2.18285199
18MP0001879_abnormal_lymphatic_vessel2.15124516
19MP0001542_abnormal_bone_strength2.12104080
20MP0009780_abnormal_chondrocyte_physiolo2.00283764
21MP0002132_abnormal_respiratory_system1.60755846
22MP0004272_abnormal_basement_membrane1.58787127
23MP0005503_abnormal_tendon_morphology1.51506630
24MP0008875_abnormal_xenobiotic_pharmacok1.49719377
25MP0001881_abnormal_mammary_gland1.47771066
26MP0005165_increased_susceptibility_to1.42923403
27MP0001175_abnormal_lung_morphology1.39882399
28MP0003950_abnormal_plasma_membrane1.39538455
29MP0009840_abnormal_foam_cell1.38859930
30MP0003566_abnormal_cell_adhesion1.34652619
31MP0005058_abnormal_lysosome_morphology1.33473427
32MP0003115_abnormal_respiratory_system1.30801428
33MP0005085_abnormal_gallbladder_physiolo1.29636310
34MP0002139_abnormal_hepatobiliary_system1.25848917
35MP0003786_premature_aging1.21042817
36MP0010678_abnormal_skin_adnexa1.20009922
37MP0005408_hypopigmentation1.15977583
38MP0002277_abnormal_respiratory_mucosa1.15705799
39MP0001666_abnormal_nutrient_absorption1.13036460
40MP0002098_abnormal_vibrissa_morphology1.07512525
41MP0004883_abnormal_blood_vessel1.06243029
42MP0003705_abnormal_hypodermis_morpholog1.06025498
43MP0004185_abnormal_adipocyte_glucose1.05948436
44MP0005387_immune_system_phenotype1.05614155
45MP0001790_abnormal_immune_system1.05614155
46MP0003303_peritoneal_inflammation1.04233682
47MP0002796_impaired_skin_barrier1.04106705
48MP0005275_abnormal_skin_tensile1.03998582
49MP0001851_eye_inflammation1.03737737
50MP0000462_abnormal_digestive_system1.03615671
51MP0005164_abnormal_response_to1.02940882
52MP0000534_abnormal_ureter_morphology1.02222571
53MP0004043_abnormal_pH_regulation1.01174668
54MP0000627_abnormal_mammary_gland1.00199089
55MP0002998_abnormal_bone_remodeling0.98495269
56MP0005023_abnormal_wound_healing0.97399032
57MP0003690_abnormal_glial_cell0.97369300
58MP0000767_abnormal_smooth_muscle0.95472779
59MP0010329_abnormal_lipoprotein_level0.94389934
60MP0002118_abnormal_lipid_homeostasis0.93753565
61MP0006138_congestive_heart_failure0.93565449
62MP0000343_altered_response_to0.91826718
63MP0000249_abnormal_blood_vessel0.91187125
64MP0003656_abnormal_erythrocyte_physiolo0.88107865
65MP0001440_abnormal_grooming_behavior0.87975604
66MP0000383_abnormal_hair_follicle0.85990956
67MP0003300_gastrointestinal_ulcer0.84107151
68MP0006054_spinal_hemorrhage0.83954304
69MP0005166_decreased_susceptibility_to0.83871417
70MP0001664_abnormal_digestion0.83785921
71MP0003091_abnormal_cell_migration0.83740889
72MP0000465_gastrointestinal_hemorrhage0.83470543
73MP0005595_abnormal_vascular_smooth0.83274228
74MP0004484_altered_response_of0.80824317
75MP0003045_fibrosis0.80300515
76MP0004264_abnormal_extraembryonic_tissu0.77646012
77MP0005397_hematopoietic_system_phenotyp0.76656560
78MP0001545_abnormal_hematopoietic_system0.76656560
79MP0003453_abnormal_keratinocyte_physiol0.76180527
80MP0003638_abnormal_response/metabolism_0.73745217
81MP0004947_skin_inflammation0.70939275
82MP0001849_ear_inflammation0.70868344
83MP0001943_abnormal_respiration0.70019211
84MP0003448_altered_tumor_morphology0.69364400
85MP0000013_abnormal_adipose_tissue0.66111840
86MP0002405_respiratory_system_inflammati0.64892883
87MP0001346_abnormal_lacrimal_gland0.62998080
88MP0009643_abnormal_urine_homeostasis0.62476666
89MP0002234_abnormal_pharynx_morphology0.62438103
90MP0002166_altered_tumor_susceptibility0.60820226
91MP0010352_gastrointestinal_tract_polyps0.60738494
92MP0005076_abnormal_cell_differentiation0.60304440
93MP0002909_abnormal_adrenal_gland0.59488488
94MP0009384_cardiac_valve_regurgitation0.57973603
95MP0001853_heart_inflammation0.57747564
96MP0002128_abnormal_blood_circulation0.57331877
97MP0003828_pulmonary_edema0.57269716
98MP0004130_abnormal_muscle_cell0.57158501
99MP0001533_abnormal_skeleton_physiology0.56975506
100MP0002060_abnormal_skin_morphology0.56051176
101MP0005025_abnormal_response_to0.55980783
102MP0002136_abnormal_kidney_physiology0.55377994
103MP0002108_abnormal_muscle_morphology0.54781335
104MP0000639_abnormal_adrenal_gland0.54630490
105MP0001502_abnormal_circadian_rhythm0.54296376
106MP0002168_other_aberrant_phenotype0.54222662
107MP0010155_abnormal_intestine_physiology0.54027743
108MP0001986_abnormal_taste_sensitivity0.53183009
109MP0005647_abnormal_sex_gland0.52892242
110* MP0002925_abnormal_cardiovascular_devel0.52678713
111MP0003329_amyloid_beta_deposits0.52249477
112MP0000681_abnormal_thyroid_gland0.52202787
113MP0005365_abnormal_bile_salt0.52177724
114MP0003075_altered_response_to0.52118984
115MP0003279_aneurysm0.52082445
116MP0002135_abnormal_kidney_morphology0.52062525
117MP0002419_abnormal_innate_immunity0.51968128
118MP0005360_urolithiasis0.51956140
119MP0008260_abnormal_autophagy0.51926989
120MP0008961_abnormal_basal_metabolism0.51678428
121MP0003436_decreased_susceptibility_to0.51426485
122MP0003890_abnormal_embryonic-extraembry0.51363104
123MP0003119_abnormal_digestive_system0.50717217
124MP0004019_abnormal_vitamin_homeostasis0.50490953
125MP0002877_abnormal_melanocyte_morpholog0.49752117
126MP0001756_abnormal_urination0.49530768
127MP0004084_abnormal_cardiac_muscle0.47851712
128* MP0001614_abnormal_blood_vessel0.47820419
129MP0004885_abnormal_endolymph0.47375330
130MP0000470_abnormal_stomach_morphology0.46133022
131MP0008438_abnormal_cutaneous_collagen0.45176238

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial fibrosis (HP:0005576)6.68140037
2Hyperactive renin-angiotensin system (HP:0000841)6.45871038
3Tachypnea (HP:0002789)6.33522596
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.06299643
5Respiratory distress (HP:0002098)5.73921860
6Chronic bronchitis (HP:0004469)5.70753674
7Gout (HP:0001997)5.57127802
8Renal salt wasting (HP:0000127)5.47811657
9Absent/shortened dynein arms (HP:0200106)5.34411100
10Dynein arm defect of respiratory motile cilia (HP:0012255)5.34411100
11Abnormal ciliary motility (HP:0012262)5.31592995
12Abnormal respiratory epithelium morphology (HP:0012253)5.29198950
13Abnormal respiratory motile cilium morphology (HP:0005938)5.29198950
14Polycythemia (HP:0001901)5.28529413
15Abnormal respiratory motile cilium physiology (HP:0012261)5.28397772
16Rhinitis (HP:0012384)4.99135039
17Neurofibrillary tangles (HP:0002185)4.21525624
18Hematochezia (HP:0002573)4.20799267
19Onycholysis (HP:0001806)4.06431994
20Hyperkalemia (HP:0002153)4.05889423
21Abnormality of the fingertips (HP:0001211)4.03155484
22Complement deficiency (HP:0004431)3.79135203
23Tubulointerstitial abnormality (HP:0001969)3.78321402
24Glomerulonephritis (HP:0000099)3.72116217
25Ulnar bowing (HP:0003031)3.70095278
26Abnormality of the nasal mucosa (HP:0000433)3.65711261
27Visceral angiomatosis (HP:0100761)3.56017804
28Tubulointerstitial nephritis (HP:0001970)3.54142608
29Systemic lupus erythematosus (HP:0002725)3.49622939
30Alveolar cell carcinoma (HP:0006519)3.45307136
31Cerebral inclusion bodies (HP:0100314)3.44842421
32Hemangiomatosis (HP:0007461)3.34951437
33Spontaneous hematomas (HP:0007420)3.32564433
34Nasal polyposis (HP:0100582)3.31083816
35Neoplasm of the tracheobronchial system (HP:0100552)3.20473017
36Abnormality of complement system (HP:0005339)3.12664607
37Long toe (HP:0010511)3.10286241
38Broad metatarsal (HP:0001783)3.08933235
39Esophageal varix (HP:0002040)3.06716482
40Abnormality of chloride homeostasis (HP:0011422)3.03897149
41Hypotension (HP:0002615)3.02826359
42Hyperaldosteronism (HP:0000859)2.93477208
43Thyroid-stimulating hormone excess (HP:0002925)2.84856816
44Chronic otitis media (HP:0000389)2.84836758
45Tubular atrophy (HP:0000092)2.76455374
46Bronchitis (HP:0012387)2.75108007
47Cerebral aneurysm (HP:0004944)2.68989153
48Osteolytic defects of the hand bones (HP:0009699)2.67430495
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.67430495
50Neonatal respiratory distress (HP:0002643)2.58884887
51Bowing of the arm (HP:0006488)2.55972266
52Bowed forearm bones (HP:0003956)2.55972266
53Supranuclear gaze palsy (HP:0000605)2.52020128
54Abnormality of renin-angiotensin system (HP:0000847)2.49919136
55Stomach cancer (HP:0012126)2.49096063
56Increased purine levels (HP:0004368)2.48897980
57Hyperuricemia (HP:0002149)2.48897980
58Loss of speech (HP:0002371)2.47173698
59Fragile nails (HP:0001808)2.43134966
60Conjunctival telangiectasia (HP:0000524)2.41222302
61Abnormal umbilical cord blood vessels (HP:0011403)2.38864775
62Single umbilical artery (HP:0001195)2.38864775
63Abnormality of the fetal cardiovascular system (HP:0010948)2.38864775
64Vascular tortuosity (HP:0004948)2.37530254
65Abnormality of purine metabolism (HP:0004352)2.37333640
66Potter facies (HP:0002009)2.36551910
67Facial shape deformation (HP:0011334)2.36551910
68Glomerulosclerosis (HP:0000096)2.36099318
69Milia (HP:0001056)2.34543271
70Bronchomalacia (HP:0002780)2.27711634
71Subacute progressive viral hepatitis (HP:0006572)2.24222155
72Pulmonary hypertension (HP:0002092)2.23149149
73Atrophic scars (HP:0001075)2.22484357
74Recurrent sinusitis (HP:0011108)2.19691878
75Aortic aneurysm (HP:0004942)2.17059181
76Glucose intolerance (HP:0000833)2.16260250
77Chronic sinusitis (HP:0011109)2.15044985
78Recurrent otitis media (HP:0000403)2.14936739
79Deep venous thrombosis (HP:0002625)2.13329936
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09461948
81Cerebral hemorrhage (HP:0001342)2.09362009
82Decreased circulating renin level (HP:0003351)2.09316475
83Growth hormone excess (HP:0000845)2.07526275
84Pulmonary fibrosis (HP:0002206)2.06509682
85Hyponatremia (HP:0002902)2.06267248
86Infertility (HP:0000789)2.06258797
87Shallow orbits (HP:0000586)2.05789748
88Stenosis of the external auditory canal (HP:0000402)2.04301321
89Pustule (HP:0200039)2.03594944
90Male infertility (HP:0003251)2.03288492
91Striae distensae (HP:0001065)2.02359394
92Rapidly progressive (HP:0003678)2.00508673
93Interstitial pulmonary disease (HP:0006530)14.1023949
94Turricephaly (HP:0000262)1.99018619
95Recurrent gram-negative bacterial infections (HP:0005420)1.94329498
96Abnormality of macrophages (HP:0004311)1.92544712
97Hypergammaglobulinemia (HP:0010702)1.91895780
98Eczematoid dermatitis (HP:0000976)1.90291593
99Atelectasis (HP:0100750)1.89869133
100Shawl scrotum (HP:0000049)1.88784523
101Megalencephaly (HP:0001355)1.86788605
102Synostosis involving the elbow (HP:0003938)1.85567356
103Humeroradial synostosis (HP:0003041)1.85567356
104Right ventricular cardiomyopathy (HP:0011663)1.85092129
105Aplasia of the phalanges of the hand (HP:0009802)1.84475882
106Aplasia involving bones of the extremities (HP:0009825)1.84475882
107Aplasia involving bones of the upper limbs (HP:0009823)1.84475882
108Hyperpituitarism (HP:0010514)1.81222559
109Hypokalemic alkalosis (HP:0001949)1.79133585
110Neoplasm of the lung (HP:0100526)1.78354011
111Abnormality of the dental pulp (HP:0006479)1.77731269
112Mildly elevated creatine phosphokinase (HP:0008180)1.75486091
113Microcytic anemia (HP:0001935)1.74906777
114Plantar hyperkeratosis (HP:0007556)1.74818749
115Pulmonary artery stenosis (HP:0004415)1.73375458
116Rectal prolapse (HP:0002035)1.73219488
117Aortic dissection (HP:0002647)1.71951578
118Hypoplasia of dental enamel (HP:0006297)1.71017153
119Camptodactyly of toe (HP:0001836)1.71012251
120Subcapsular cataract (HP:0000523)1.70162380
121Bronchiectasis (HP:0002110)1.69307812
122Exertional dyspnea (HP:0002875)1.69179116
123Prolonged neonatal jaundice (HP:0006579)1.68763282
124Nephritis (HP:0000123)1.67735773
125Split foot (HP:0001839)1.67657489
126Stage 5 chronic kidney disease (HP:0003774)1.66563113
127Vascular calcification (HP:0004934)1.66242373
128Recurrent bronchitis (HP:0002837)1.65530395
129Ankle contracture (HP:0006466)1.63531877
130Segmental peripheral demyelination/remyelination (HP:0003481)1.62134657
131Abnormality of the 2nd finger (HP:0004100)1.61538919
132Lip pit (HP:0100267)1.60433232
133Broad distal phalanx of finger (HP:0009836)1.59656612
134Abnormality of the gastric mucosa (HP:0004295)1.58124443
135Abnormality of sodium homeostasis (HP:0010931)1.57875903
136Adrenal overactivity (HP:0002717)1.57840537
137Thickened helices (HP:0000391)1.57215952
138Increased CSF protein (HP:0002922)1.57185687
139Progressive sensorineural hearing impairment (HP:0000408)1.56123664
140Dehydration (HP:0001944)1.55634562
141Cavernous hemangioma (HP:0001048)1.55493293
142Aneurysm (HP:0002617)1.55050917
143Arterial tortuosity (HP:0005116)1.55001610
144Abnormal glucose tolerance (HP:0001952)1.54825800
145Mitral stenosis (HP:0001718)1.54088149
146Cone-rod dystrophy (HP:0000548)1.53562887
147Cardiovascular calcification (HP:0011915)1.50460520
148Bell-shaped thorax (HP:0001591)1.48552563
149Neoplasm of the respiratory system (HP:0100606)1.47418499
150Abnormality of the dental root (HP:0006486)1.46591428
151Taurodontia (HP:0000679)1.46591428
152Abnormality of permanent molar morphology (HP:0011071)1.46591428
153Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.45872934
154Portal hypertension (HP:0001409)1.45029431
155Abnormality of renal excretion (HP:0011036)1.40077517
156Abnormality of molar (HP:0011077)1.39432734
157Abnormality of molar morphology (HP:0011070)1.39432734
158Distal lower limb muscle weakness (HP:0009053)1.39281633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.19471255
2FGFR24.72262999
3STK244.11855683
4LRRK23.20610905
5TGFBR23.17786721
6TRIB32.73577768
7ZAP702.71282428
8RIPK12.45786354
9EPHA22.44845969
10EPHB12.41659869
11LATS12.38591481
12PAK42.37712704
13PDGFRB2.20118332
14MST42.09545099
15DAPK21.98497454
16LMTK21.96661591
17EPHB21.95703979
18NLK1.87680685
19CAMK1D1.85561325
20FGFR41.76497448
21STK101.74270965
22FER1.72516027
23ILK1.70199405
24MST1R1.63124512
25ERN11.57558709
26PTK61.56131493
27MAP3K21.47225768
28BCR1.45283139
29MAP3K31.44209914
30TRPM71.43131020
31CDC42BPA1.42736587
32GRK11.37811081
33IRAK11.28885153
34MAP3K91.28802694
35KSR21.28180986
36SIK11.27984294
37PDGFRA1.26101248
38MAPK151.23240801
39EPHA31.20474297
40MET1.16010611
41CAMK1G1.15247873
42TAOK31.15094349
43TESK11.10718116
44CDK61.07407077
45YES11.04445734
46GSK3A1.04209297
47FGFR31.03430284
48MYLK1.01966155
49MAP3K61.00854972
50NEK60.99920781
51LATS20.98270706
52MAPKAPK30.96449201
53STK30.95262016
54STK38L0.94761084
55NME10.92982236
56PKN20.89861985
57ERBB30.85847251
58HIPK20.85004430
59PTK20.83633007
60SGK20.82898710
61PRKD10.78745133
62CSK0.76652699
63MAP3K140.75910707
64DDR20.75272787
65EGFR0.75186926
66MAP3K130.71065527
67BRSK20.69733560
68TBK10.67658636
69KDR0.67609975
70PDPK10.64020210
71MAP2K20.63264782
72MAP2K30.62682551
73SGK4940.61506092
74SGK2230.61506092
75MELK0.61144470
76ERBB20.58879429
77TGFBR10.57965928
78EEF2K0.57696322
79FRK0.56136620
80MAPK70.56121644
81FGFR10.55301599
82NEK90.54413617
83MARK20.54057968
84PTK2B0.53111919
85MAP3K10.52604040
86KIT0.49207051
87TYRO30.48594357
88RET0.45189866
89MAP3K120.44746937
90RPS6KA40.43680391
91PRKCE0.43616495
92NTRK10.43411071
93MAP2K10.42590493
94BMX0.42550426
95MATK0.42490465
96ABL10.41101272
97LIMK10.40457853
98INSR0.40439652
99JAK10.40372170
100DMPK0.40130064
101STK390.38965987
102PRPF4B0.37740054
103MAP3K70.36800329
104PRKCQ0.34946459
105PRKG20.34710001
106ROCK10.34482573
107WNK40.33818430
108PRKCD0.33680409
109TYK20.32792645
110TTN0.31570893
111PDK20.31345621
112MAPK120.31237144
113MAPKAPK20.29200861
114AKT30.29011667
115SGK30.28396501
116TAOK10.28199127
117CHUK0.27914430
118ABL20.27659381
119DAPK30.27295572
120MAPK30.27025885
121BLK0.26922724
122MAP3K80.26893600
123ROCK20.26727438
124IGF1R0.26037512
125JAK20.25749882
126DAPK10.25706534
127FGR0.25362881
128IRAK30.22867531
129MTOR0.22838063
130PRKAA20.22423849
131STK380.22178190
132PRKCH0.21918544
133PDK40.21202536
134PDK30.21202536
135RPS6KA20.19585453

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.26582708
2Fatty acid biosynthesis_Homo sapiens_hsa000614.05251440
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.10812273
4ECM-receptor interaction_Homo sapiens_hsa045122.41629515
5Adherens junction_Homo sapiens_hsa045202.37884263
6Asthma_Homo sapiens_hsa053102.11352536
7Lysosome_Homo sapiens_hsa041422.08445899
8Renin-angiotensin system_Homo sapiens_hsa046142.02933300
9Tight junction_Homo sapiens_hsa045301.94846996
10Autoimmune thyroid disease_Homo sapiens_hsa053201.91697650
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.84738751
12* Mineral absorption_Homo sapiens_hsa049781.80108372
13Allograft rejection_Homo sapiens_hsa053301.77109026
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75453079
15Graft-versus-host disease_Homo sapiens_hsa053321.73567194
16Phenylalanine metabolism_Homo sapiens_hsa003601.64070446
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60507218
18Circadian rhythm_Homo sapiens_hsa047101.60311286
19Focal adhesion_Homo sapiens_hsa045101.54627069
20Phagosome_Homo sapiens_hsa041451.54179395
21Bladder cancer_Homo sapiens_hsa052191.50209464
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.45926643
23Hippo signaling pathway_Homo sapiens_hsa043901.40182783
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36177132
25Type I diabetes mellitus_Homo sapiens_hsa049401.34319112
26Small cell lung cancer_Homo sapiens_hsa052221.34152582
27Renal cell carcinoma_Homo sapiens_hsa052111.29941573
28Pertussis_Homo sapiens_hsa051331.28639182
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.25113323
30Amoebiasis_Homo sapiens_hsa051461.25064547
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25035857
32Tyrosine metabolism_Homo sapiens_hsa003501.21399584
33Histidine metabolism_Homo sapiens_hsa003401.21038149
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20738062
35Fatty acid degradation_Homo sapiens_hsa000711.17021035
36ABC transporters_Homo sapiens_hsa020101.16345769
37Fatty acid metabolism_Homo sapiens_hsa012121.13475252
38Leishmaniasis_Homo sapiens_hsa051401.11840365
39beta-Alanine metabolism_Homo sapiens_hsa004101.10263332
40Malaria_Homo sapiens_hsa051441.08956998
41Antigen processing and presentation_Homo sapiens_hsa046121.08750950
42Tryptophan metabolism_Homo sapiens_hsa003801.08069257
43VEGF signaling pathway_Homo sapiens_hsa043701.08024945
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07395484
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02768590
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.02011540
47Thyroid cancer_Homo sapiens_hsa052161.00668427
48PPAR signaling pathway_Homo sapiens_hsa033201.00029230
49Bile secretion_Homo sapiens_hsa049760.99516646
50Rap1 signaling pathway_Homo sapiens_hsa040150.99333629
51Endocytosis_Homo sapiens_hsa041440.97818392
52Dorso-ventral axis formation_Homo sapiens_hsa043200.96823564
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96693551
54Toxoplasmosis_Homo sapiens_hsa051450.95892309
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95810732
56Ether lipid metabolism_Homo sapiens_hsa005650.95789913
57Fatty acid elongation_Homo sapiens_hsa000620.95609036
58Proteoglycans in cancer_Homo sapiens_hsa052050.94672816
59Sphingolipid metabolism_Homo sapiens_hsa006000.93107554
60Platelet activation_Homo sapiens_hsa046110.92010700
61Pancreatic cancer_Homo sapiens_hsa052120.91609104
62TGF-beta signaling pathway_Homo sapiens_hsa043500.88171121
63Endometrial cancer_Homo sapiens_hsa052130.87555752
64Notch signaling pathway_Homo sapiens_hsa043300.87119412
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86279271
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.86130127
67Selenocompound metabolism_Homo sapiens_hsa004500.85366214
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82975455
69Vibrio cholerae infection_Homo sapiens_hsa051100.82677653
70Gastric acid secretion_Homo sapiens_hsa049710.82623755
71Complement and coagulation cascades_Homo sapiens_hsa046100.82478897
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82010071
73Linoleic acid metabolism_Homo sapiens_hsa005910.81989445
74Hematopoietic cell lineage_Homo sapiens_hsa046400.80451178
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79460881
76Glutathione metabolism_Homo sapiens_hsa004800.77974105
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.77321555
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75168946
79Influenza A_Homo sapiens_hsa051640.74663226
80Hepatitis C_Homo sapiens_hsa051600.72973497
81Prolactin signaling pathway_Homo sapiens_hsa049170.72914725
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71141018
83Renin secretion_Homo sapiens_hsa049240.70670613
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68622205
85Pentose phosphate pathway_Homo sapiens_hsa000300.68488635
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68324454
87Salmonella infection_Homo sapiens_hsa051320.67589773
88Rheumatoid arthritis_Homo sapiens_hsa053230.66845225
89Pathways in cancer_Homo sapiens_hsa052000.66466463
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64002315
91Arachidonic acid metabolism_Homo sapiens_hsa005900.63274502
92Insulin resistance_Homo sapiens_hsa049310.63075701
93Viral myocarditis_Homo sapiens_hsa054160.62996397
94Taste transduction_Homo sapiens_hsa047420.62773946
95Axon guidance_Homo sapiens_hsa043600.62721406
96Other glycan degradation_Homo sapiens_hsa005110.61116508
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.60989706
98Protein digestion and absorption_Homo sapiens_hsa049740.59688803
99Tuberculosis_Homo sapiens_hsa051520.58041110
100Choline metabolism in cancer_Homo sapiens_hsa052310.57990429
101Retinol metabolism_Homo sapiens_hsa008300.57370857
102Starch and sucrose metabolism_Homo sapiens_hsa005000.57237484
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56674979
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.56080173
105Chronic myeloid leukemia_Homo sapiens_hsa052200.55759591
106MicroRNAs in cancer_Homo sapiens_hsa052060.55319122
107Thyroid hormone synthesis_Homo sapiens_hsa049180.53698438
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.53402582
109Inositol phosphate metabolism_Homo sapiens_hsa005620.51967592
110Acute myeloid leukemia_Homo sapiens_hsa052210.51623311
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49227537
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48943127
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48240746
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48119661
115Salivary secretion_Homo sapiens_hsa049700.47446159
116Vitamin digestion and absorption_Homo sapiens_hsa049770.47377977
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46600719
118Staphylococcus aureus infection_Homo sapiens_hsa051500.45945078
119Glycerolipid metabolism_Homo sapiens_hsa005610.44818148
120Prostate cancer_Homo sapiens_hsa052150.44579194
121Prion diseases_Homo sapiens_hsa050200.43841337
122Chemical carcinogenesis_Homo sapiens_hsa052040.43819237
123Peroxisome_Homo sapiens_hsa041460.43496357
124AMPK signaling pathway_Homo sapiens_hsa041520.43179416
125Apoptosis_Homo sapiens_hsa042100.43108240
126Collecting duct acid secretion_Homo sapiens_hsa049660.42163714
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41841488
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41769823
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41453487
130Dilated cardiomyopathy_Homo sapiens_hsa054140.41365220
131Ovarian steroidogenesis_Homo sapiens_hsa049130.40752412
132Colorectal cancer_Homo sapiens_hsa052100.40690715
133Pancreatic secretion_Homo sapiens_hsa049720.40333569
134TNF signaling pathway_Homo sapiens_hsa046680.38771815
135Osteoclast differentiation_Homo sapiens_hsa043800.37575482
136Estrogen signaling pathway_Homo sapiens_hsa049150.35829357

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