SLC35A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)4.52220892
2polyketide metabolic process (GO:0030638)4.52220892
3doxorubicin metabolic process (GO:0044598)4.52220892
4signal peptide processing (GO:0006465)4.49604433
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.49126660
6piRNA metabolic process (GO:0034587)4.10647278
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.05728368
8NADH dehydrogenase complex assembly (GO:0010257)4.05728368
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.05728368
10protein complex biogenesis (GO:0070271)4.01605177
11cell wall macromolecule catabolic process (GO:0016998)3.93628672
12response to pheromone (GO:0019236)3.89773282
13cullin deneddylation (GO:0010388)3.87285207
14protein deneddylation (GO:0000338)3.84533174
15respiratory chain complex IV assembly (GO:0008535)3.83035675
16COPI coating of Golgi vesicle (GO:0048205)3.76627983
17Golgi transport vesicle coating (GO:0048200)3.76627983
18protein polyglutamylation (GO:0018095)3.72754878
19mitochondrial respiratory chain complex assembly (GO:0033108)3.70361709
20oxidative phosphorylation (GO:0006119)3.70132238
21regulation of meiosis I (GO:0060631)3.64558216
22proteasome assembly (GO:0043248)3.64003972
23response to nitrosative stress (GO:0051409)3.61153909
24protein-cofactor linkage (GO:0018065)3.58529711
25positive regulation of receptor biosynthetic process (GO:0010870)3.57900001
26cell wall macromolecule metabolic process (GO:0044036)3.52184171
27inositol phosphate catabolic process (GO:0071545)3.50773437
28protein neddylation (GO:0045116)3.46152889
29platelet dense granule organization (GO:0060155)3.42183613
30aldehyde catabolic process (GO:0046185)3.42181825
31preassembly of GPI anchor in ER membrane (GO:0016254)3.41518430
32inositol phosphate dephosphorylation (GO:0046855)3.35508739
33phosphorylated carbohydrate dephosphorylation (GO:0046838)3.35508739
34GPI anchor metabolic process (GO:0006505)3.35092533
35UDP-N-acetylglucosamine metabolic process (GO:0006047)3.34551205
36retinal cone cell development (GO:0046549)3.32672087
37neural tube formation (GO:0001841)3.30724526
38cytochrome complex assembly (GO:0017004)3.29008942
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27160658
40GPI anchor biosynthetic process (GO:0006506)3.26762764
41misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.25112097
42establishment of integrated proviral latency (GO:0075713)3.22230433
43L-phenylalanine catabolic process (GO:0006559)3.13283398
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13283398
45deoxyribose phosphate biosynthetic process (GO:0046385)3.13058408
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.13058408
47anterograde synaptic vesicle transport (GO:0048490)3.11019168
48ATP synthesis coupled proton transport (GO:0015986)3.10421740
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10421740
50regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.10331922
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09865222
52aminoglycoside antibiotic metabolic process (GO:0030647)3.07088323
53mitochondrial DNA replication (GO:0006264)3.06005209
54nucleoside salvage (GO:0043174)3.05632633
55respiratory electron transport chain (GO:0022904)3.02925693
56electron transport chain (GO:0022900)3.02370188
57C-terminal protein lipidation (GO:0006501)3.00036456
58heme transport (GO:0015886)2.97230437
59quinone biosynthetic process (GO:1901663)2.96467210
60ubiquinone biosynthetic process (GO:0006744)2.96467210
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.95086365
62L-phenylalanine metabolic process (GO:0006558)2.95086365
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.92334481
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.92205766
65axoneme assembly (GO:0035082)2.91462666
66pyrimidine nucleoside biosynthetic process (GO:0046134)2.89779181
67protein localization to cilium (GO:0061512)2.88602721
68aromatic amino acid family catabolic process (GO:0009074)2.88342067
69ketone body metabolic process (GO:1902224)2.87493643
70regulation of cellular amino acid metabolic process (GO:0006521)2.87365948
71regulation of protein glycosylation (GO:0060049)2.87214762
72establishment of viral latency (GO:0019043)2.87126103
73synapsis (GO:0007129)2.86949747
74regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.85892326
75regulation of cilium movement (GO:0003352)2.85275882
76cellular ketone body metabolic process (GO:0046950)2.84128387
77response to misfolded protein (GO:0051788)2.83516581
78nucleobase biosynthetic process (GO:0046112)2.83080611
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82916990
80dopamine transport (GO:0015872)2.81027368
81ubiquinone metabolic process (GO:0006743)2.80394005
82peptidyl-histidine modification (GO:0018202)2.79480872
83epithelial cilium movement (GO:0003351)2.79091691
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78361005
85xenobiotic catabolic process (GO:0042178)2.77404857
86tryptophan metabolic process (GO:0006568)2.77403593
87quinone metabolic process (GO:1901661)2.77322238
88L-methionine salvage (GO:0071267)2.77081121
89L-methionine biosynthetic process (GO:0071265)2.77081121
90amino acid salvage (GO:0043102)2.77081121
91cilium morphogenesis (GO:0060271)2.76619861
92telomere maintenance via semi-conservative replication (GO:0032201)2.75819233
93regulation of metalloenzyme activity (GO:0048552)2.75633571
94water-soluble vitamin biosynthetic process (GO:0042364)2.74934469
95regulation of mitochondrial translation (GO:0070129)2.74291304
96intraciliary transport (GO:0042073)2.74136771
97C-terminal protein amino acid modification (GO:0018410)2.73533129
98ribosomal small subunit assembly (GO:0000028)2.73227342
99deoxyribonucleotide biosynthetic process (GO:0009263)2.72229346
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70441243
101viral protein processing (GO:0019082)2.70369960
102tryptophan catabolic process (GO:0006569)2.69925329
103indole-containing compound catabolic process (GO:0042436)2.69925329
104indolalkylamine catabolic process (GO:0046218)2.69925329
105organelle disassembly (GO:1903008)2.68681962
106pyrimidine nucleoside salvage (GO:0043097)2.66708302
107pyrimidine-containing compound salvage (GO:0008655)2.66708302
108S-adenosylmethionine metabolic process (GO:0046500)2.66507955
109positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.66418412
110histamine secretion (GO:0001821)2.66298203
111branched-chain amino acid catabolic process (GO:0009083)2.66274246
112exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65472911
113aerobic respiration (GO:0009060)2.65077771
114DNA strand elongation involved in DNA replication (GO:0006271)2.64399268
115DNA strand elongation (GO:0022616)2.63226101
116DNA double-strand break processing (GO:0000729)2.63037973
117fucose catabolic process (GO:0019317)2.62993009
118L-fucose metabolic process (GO:0042354)2.62993009
119L-fucose catabolic process (GO:0042355)2.62993009
120cilium organization (GO:0044782)2.62769514
121glycolipid biosynthetic process (GO:0009247)2.62419150
122polyol catabolic process (GO:0046174)2.62111039
123glyoxylate metabolic process (GO:0046487)2.61566033
124negative regulation of ligase activity (GO:0051352)2.60354634
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.60354634
126regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60326645
127purine nucleobase biosynthetic process (GO:0009113)2.60039644
128oxaloacetate metabolic process (GO:0006107)2.59413705
129intestinal epithelial cell development (GO:0060576)2.58291628
130histone H2A acetylation (GO:0043968)2.57913968
131purine-containing compound salvage (GO:0043101)2.57512917
132fucose metabolic process (GO:0006004)2.56484465
133opsonization (GO:0008228)2.56183319
134pyrimidine nucleoside metabolic process (GO:0006213)2.55628836
135cilium assembly (GO:0042384)2.55525158
136positive regulation of mitochondrial fission (GO:0090141)2.55469733
137telomere maintenance via recombination (GO:0000722)2.55341795
138adenosine metabolic process (GO:0046085)2.53584602
139protein maturation by protein folding (GO:0022417)2.53571793
140regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53531149
141mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52930744
142pyrimidine-containing compound biosynthetic process (GO:0072528)2.52573879
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52009231
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52009231
145peptide catabolic process (GO:0043171)2.51731770
146nucleotide-sugar metabolic process (GO:0009225)2.51071368
147DNA deamination (GO:0045006)2.50350948
148DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50151608
149regulation of receptor biosynthetic process (GO:0010869)2.49945564
150termination of RNA polymerase III transcription (GO:0006386)2.49700089
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.49700089
152histone H2A ubiquitination (GO:0033522)2.49680895
153pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.48661642
154peroxisome fission (GO:0016559)2.48574368
155short-chain fatty acid metabolic process (GO:0046459)2.47027741
156antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46164126
157IMP biosynthetic process (GO:0006188)2.45573240
158centriole replication (GO:0007099)2.43457377
159* proton transport (GO:0015992)2.43004554
160regulation of interleukin-8 secretion (GO:2000482)2.41704567
161mannosylation (GO:0097502)2.40659983
162peptidyl-cysteine modification (GO:0018198)2.40038593
163nonmotile primary cilium assembly (GO:0035058)2.39662779
164DNA methylation involved in gamete generation (GO:0043046)2.39337778
165* hydrogen transport (GO:0006818)2.39192764
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.38897047
167purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.36527861
168negative regulation of neurological system process (GO:0031645)2.35463771
169rRNA methylation (GO:0031167)2.34798294
170hydrogen ion transmembrane transport (GO:1902600)2.34656725
171indolalkylamine metabolic process (GO:0006586)2.33486535
172intra-S DNA damage checkpoint (GO:0031573)2.31467792
173melanosome transport (GO:0032402)2.31056324
174ribonucleoprotein complex disassembly (GO:0032988)2.30064552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.74225086
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47000466
3E2F7_22180533_ChIP-Seq_HELA_Human4.17957718
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.49249235
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.24620104
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24003831
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.18150824
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14925971
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.99181778
10ZNF274_21170338_ChIP-Seq_K562_Hela2.89421049
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.84575116
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.83999048
13IGF1R_20145208_ChIP-Seq_DFB_Human2.69772785
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65285456
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61043654
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60462228
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.55487495
18VDR_22108803_ChIP-Seq_LS180_Human2.52917782
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52436741
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.50786747
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50592932
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.43329992
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41668095
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40763500
25ELK1_19687146_ChIP-ChIP_HELA_Human2.33824123
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31498932
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30967293
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29420615
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27070638
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.25482332
31MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19384470
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12791247
33* ETS1_20019798_ChIP-Seq_JURKAT_Human2.11631342
34DCP1A_22483619_ChIP-Seq_HELA_Human2.08567799
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04906340
36PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00624271
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99034673
38ER_23166858_ChIP-Seq_MCF-7_Human1.95494160
39P300_19829295_ChIP-Seq_ESCs_Human1.93364276
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93264144
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.91516812
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91058288
43VDR_23849224_ChIP-Seq_CD4+_Human1.89978508
44GATA1_22025678_ChIP-Seq_K562_Human1.88539018
45FOXP3_21729870_ChIP-Seq_TREG_Human1.82189666
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79950145
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71207337
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71178387
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69688624
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65563718
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63455530
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61021266
53IRF1_19129219_ChIP-ChIP_H3396_Human1.60923580
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60445683
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.58365675
56AR_21909140_ChIP-Seq_LNCAP_Human1.57085232
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56785081
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.56072620
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.55224504
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54751825
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52861544
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52817702
63CBP_20019798_ChIP-Seq_JUKART_Human1.52817702
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52316731
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49053275
66NANOG_19829295_ChIP-Seq_ESCs_Human1.48369596
67SOX2_19829295_ChIP-Seq_ESCs_Human1.48369596
68TP53_22573176_ChIP-Seq_HFKS_Human1.48269905
69GABP_19822575_ChIP-Seq_HepG2_Human1.46768751
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43186916
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.42190300
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41832729
73BCAT_22108803_ChIP-Seq_LS180_Human1.41482460
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.41141050
75SMAD4_21799915_ChIP-Seq_A2780_Human1.40964689
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40738401
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40126493
78AR_25329375_ChIP-Seq_VCAP_Human1.38484189
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37050447
80FUS_26573619_Chip-Seq_HEK293_Human1.36912989
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36807727
82PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36299448
83EWS_26573619_Chip-Seq_HEK293_Human1.35246216
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35193723
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33443686
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33206153
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32793670
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31613823
89CRX_20693478_ChIP-Seq_RETINA_Mouse1.31484154
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.31450478
91TTF2_22483619_ChIP-Seq_HELA_Human1.31342589
92MYC_18940864_ChIP-ChIP_HL60_Human1.31212055
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.31091761
94* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31068525
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30940746
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.30640239
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30624450
98XRN2_22483619_ChIP-Seq_HELA_Human1.30060722
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29437417
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28295506
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.28295506
102ELK1_22589737_ChIP-Seq_MCF10A_Human1.27965153
103P53_22387025_ChIP-Seq_ESCs_Mouse1.27870984
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27143999
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26147195
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25270333
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24877479
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24640630
109TCF4_22108803_ChIP-Seq_LS180_Human1.24437395
110TAF15_26573619_Chip-Seq_HEK293_Human1.24319334
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.23911940
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18181830
113STAT3_23295773_ChIP-Seq_U87_Human1.17849868
114FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17783859
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.17501792
116CDX2_22108803_ChIP-Seq_LS180_Human1.17010143
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.16335156
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15228324
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14707772
120* TCF4_23295773_ChIP-Seq_U87_Human1.14666532
121* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14047803
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.14010880
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.13441972
124RUNX2_22187159_ChIP-Seq_PCA_Human1.13286042
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12559120
126STAT3_18555785_Chip-Seq_ESCs_Mouse1.11772363
127SMAD3_21741376_ChIP-Seq_EPCs_Human1.11303872
128MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11247157
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10838072
130* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10483221
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10341302
132PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09728918
133GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09017718
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08050165
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07922463
136WT1_19549856_ChIP-ChIP_CCG9911_Human1.07726670
137IRF8_21731497_ChIP-ChIP_J774_Mouse1.07658883
138P300_18555785_Chip-Seq_ESCs_Mouse1.07203450
139E2F1_18555785_Chip-Seq_ESCs_Mouse1.06655008
140PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06459291
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06035050
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05730995
143CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05592694
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04741774
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01733464
146IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00411574
147* E2F1_21310950_ChIP-Seq_MCF-7_Human0.99931230
148POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99632628
149HTT_18923047_ChIP-ChIP_STHdh_Human0.99436395
150ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98642968
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98182251
152TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93053389
153TP63_19390658_ChIP-ChIP_HaCaT_Human0.92406306
154ELF5_23300383_ChIP-Seq_T47D_Human0.92204324
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91076185
156FLI1_27457419_Chip-Seq_LIVER_Mouse0.90808570
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89433689
158LXR_22158963_ChIP-Seq_LIVER_Mouse0.89332103
159* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89005687
160CLOCK_20551151_ChIP-Seq_293T_Human0.88518197
161GBX2_23144817_ChIP-Seq_PC3_Human0.88358331
162SOX2_20726797_ChIP-Seq_SW620_Human0.84437559
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84432723
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83789193
165MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81725217
166YY1_21170310_ChIP-Seq_MESCs_Mouse0.81395567
167FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81053620
168ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80792956
169AR_20517297_ChIP-Seq_VCAP_Human0.80475879
170* SALL4_22934838_ChIP-ChIP_CD34+_Human0.79808264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.03628410
2MP0003806_abnormal_nucleotide_metabolis3.76610893
3MP0009697_abnormal_copulation3.68962614
4MP0005365_abnormal_bile_salt3.52361642
5MP0006054_spinal_hemorrhage3.34863759
6MP0003787_abnormal_imprinting3.24809709
7MP0000569_abnormal_digit_pigmentation3.15422622
8MP0005084_abnormal_gallbladder_morpholo3.10519807
9MP0005085_abnormal_gallbladder_physiolo3.03395117
10MP0008875_abnormal_xenobiotic_pharmacok2.87406439
11MP0008877_abnormal_DNA_methylation2.80472842
12MP0010368_abnormal_lymphatic_system2.51535853
13MP0005360_urolithiasis2.49584110
14MP0003186_abnormal_redox_activity2.46754570
15MP0005408_hypopigmentation2.32064999
16MP0003880_abnormal_central_pattern2.26727027
17MP0005174_abnormal_tail_pigmentation2.21438363
18MP0006072_abnormal_retinal_apoptosis2.21244175
19MP0009379_abnormal_foot_pigmentation2.17162160
20MP0003195_calcinosis2.09709511
21MP0002102_abnormal_ear_morphology2.00141321
22MP0001879_abnormal_lymphatic_vessel1.99529142
23MP0004782_abnormal_surfactant_physiolog1.98897063
24MP0005503_abnormal_tendon_morphology1.92924763
25MP0005220_abnormal_exocrine_pancreas1.92037039
26MP0005551_abnormal_eye_electrophysiolog1.90158856
27MP0003724_increased_susceptibility_to1.88997404
28MP0003693_abnormal_embryo_hatching1.86939663
29MP0000372_irregular_coat_pigmentation1.81410161
30MP0010386_abnormal_urinary_bladder1.79686953
31MP0004142_abnormal_muscle_tone1.76660344
32MP0005248_abnormal_Harderian_gland1.75301484
33MP0003718_maternal_effect1.72447799
34MP0005253_abnormal_eye_physiology1.71803680
35MP0000678_abnormal_parathyroid_gland1.69167914
36MP0000427_abnormal_hair_cycle1.69107855
37MP0004043_abnormal_pH_regulation1.67165225
38MP0006036_abnormal_mitochondrial_physio1.66546512
39MP0005083_abnormal_biliary_tract1.66382893
40MP0005171_absent_coat_pigmentation1.66241424
41MP0002938_white_spotting1.64443903
42MP0001188_hyperpigmentation1.62805528
43MP0010030_abnormal_orbit_morphology1.62678710
44MP0004147_increased_porphyrin_level1.60341095
45MP0003183_abnormal_peptide_metabolism1.55841941
46MP0009046_muscle_twitch1.55054800
47MP0003943_abnormal_hepatobiliary_system1.54227147
48MP0002909_abnormal_adrenal_gland1.52861698
49MP0004264_abnormal_extraembryonic_tissu1.52143516
50MP0005379_endocrine/exocrine_gland_phen1.50655870
51MP0008438_abnormal_cutaneous_collagen1.49511984
52MP0000015_abnormal_ear_pigmentation1.48703255
53MP0008004_abnormal_stomach_pH1.44953449
54MP0000681_abnormal_thyroid_gland1.43802475
55MP0006292_abnormal_olfactory_placode1.43166244
56MP0001764_abnormal_homeostasis1.40184053
57MP0003252_abnormal_bile_duct1.38738528
58MP0005075_abnormal_melanosome_morpholog1.37842634
59MP0002837_dystrophic_cardiac_calcinosis1.37776377
60MP0002132_abnormal_respiratory_system1.37285628
61MP0002163_abnormal_gland_morphology1.37015565
62MP0001984_abnormal_olfaction1.36928691
63MP0005646_abnormal_pituitary_gland1.36280650
64MP0001666_abnormal_nutrient_absorption1.33719776
65MP0008007_abnormal_cellular_replicative1.32310098
66MP0008872_abnormal_physiological_respon1.32144366
67MP0002095_abnormal_skin_pigmentation1.32073902
68MP0004215_abnormal_myocardial_fiber1.30884798
69MP0003045_fibrosis1.30814108
70MP0003122_maternal_imprinting1.30191373
71MP0010234_abnormal_vibrissa_follicle1.29559653
72MP0010329_abnormal_lipoprotein_level1.26855105
73MP0005636_abnormal_mineral_homeostasis1.25672072
74MP0003868_abnormal_feces_composition1.25463029
75MP0005332_abnormal_amino_acid1.24440122
76MP0003890_abnormal_embryonic-extraembry1.23753232
77MP0002877_abnormal_melanocyte_morpholog1.23416073
78MP0002876_abnormal_thyroid_physiology1.22101558
79MP0003786_premature_aging1.21620607
80MP0008058_abnormal_DNA_repair1.21137700
81MP0002928_abnormal_bile_duct1.19420702
82MP0006082_CNS_inflammation1.18323267
83MP0002090_abnormal_vision1.17332870
84MP0001486_abnormal_startle_reflex1.16853864
85MP0006035_abnormal_mitochondrial_morpho1.15898582
86MP0000049_abnormal_middle_ear1.14675482
87MP0001968_abnormal_touch/_nociception1.13028923
88MP0003011_delayed_dark_adaptation1.12741468
89MP0002006_tumorigenesis1.12175052
90MP0002272_abnormal_nervous_system1.11350410
91MP0009785_altered_susceptibility_to1.10182580
92MP0002166_altered_tumor_susceptibility1.10066933
93MP0008995_early_reproductive_senescence1.09173719
94MP0006276_abnormal_autonomic_nervous1.07690651
95MP0004957_abnormal_blastocyst_morpholog1.07640312
96MP0001501_abnormal_sleep_pattern1.05795778
97MP0002277_abnormal_respiratory_mucosa1.04796736
98MP0009745_abnormal_behavioral_response1.04055071
99MP0005395_other_phenotype1.02933566
100MP0004924_abnormal_behavior0.99561378
101MP0005386_behavior/neurological_phenoty0.99561378
102MP0001929_abnormal_gametogenesis0.98198080
103MP0009384_cardiac_valve_regurgitation0.95938970
104MP0005367_renal/urinary_system_phenotyp0.95889526
105MP0000516_abnormal_urinary_system0.95889526
106MP0003942_abnormal_urinary_system0.93559502
107MP0000013_abnormal_adipose_tissue0.92789626
108MP0010094_abnormal_chromosome_stability0.92657863
109MP0001835_abnormal_antigen_presentation0.92546724
110MP0002249_abnormal_larynx_morphology0.90552538
111MP0008932_abnormal_embryonic_tissue0.89983102
112MP0001919_abnormal_reproductive_system0.89243938
113MP0000538_abnormal_urinary_bladder0.89133123
114MP0000537_abnormal_urethra_morphology0.87950378
115MP0005645_abnormal_hypothalamus_physiol0.87362364
116MP0004883_abnormal_blood_vessel0.85924066
117MP0000613_abnormal_salivary_gland0.84116485
118MP0001664_abnormal_digestion0.84095366
119MP0004484_altered_response_of0.83617264
120MP0009643_abnormal_urine_homeostasis0.83043973
121MP0005319_abnormal_enzyme/_coenzyme0.82728222
122MP0004019_abnormal_vitamin_homeostasis0.82155717
123MP0001944_abnormal_pancreas_morphology0.81937431
124MP0002736_abnormal_nociception_after0.81015238
125MP0002160_abnormal_reproductive_system0.80895365
126MP0002229_neurodegeneration0.80378537
127MP0005535_abnormal_body_temperature0.79929567
128MP0003279_aneurysm0.79030102
129MP0002572_abnormal_emotion/affect_behav0.78873616
130MP0000465_gastrointestinal_hemorrhage0.78125642
131MP0005584_abnormal_enzyme/coenzyme_acti0.77107763
132MP0001986_abnormal_taste_sensitivity0.76516945
133MP0002557_abnormal_social/conspecific_i0.75672022
134MP0000653_abnormal_sex_gland0.75161501
135MP0000163_abnormal_cartilage_morphology0.73511805
136MP0003567_abnormal_fetal_cardiomyocyte0.73355619
137MP0002751_abnormal_autonomic_nervous0.73265182
138MP0000639_abnormal_adrenal_gland0.71754866
139MP0001119_abnormal_female_reproductive0.71394555
140MP0000490_abnormal_crypts_of0.70379044
141MP0002638_abnormal_pupillary_reflex0.70361653
142MP0005376_homeostasis/metabolism_phenot0.69440646
143MP0003121_genomic_imprinting0.69190930
144MP0004272_abnormal_basement_membrane0.68237860
145MP0001529_abnormal_vocalization0.67255818
146MP0001756_abnormal_urination0.66250427
147MP0009053_abnormal_anal_canal0.64498499
148MP0009764_decreased_sensitivity_to0.63959796
149MP0000598_abnormal_liver_morphology0.62433938
150MP0001663_abnormal_digestive_system0.62230188
151MP0000230_abnormal_systemic_arterial0.61447374
152MP0000631_abnormal_neuroendocrine_gland0.61128208
153MP0001905_abnormal_dopamine_level0.60838955
154MP0001873_stomach_inflammation0.60110013
155MP0002932_abnormal_joint_morphology0.58537929
156MP0005389_reproductive_system_phenotype0.56725780

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.60306190
2Abnormal mitochondria in muscle tissue (HP:0008316)4.30735914
3Aplastic anemia (HP:0001915)4.06725127
4Hepatic necrosis (HP:0002605)4.03996673
5Acute encephalopathy (HP:0006846)4.03542446
6Mitochondrial inheritance (HP:0001427)3.97031237
7Progressive macrocephaly (HP:0004481)3.85711985
8Increased CSF lactate (HP:0002490)3.69289938
9Hepatocellular necrosis (HP:0001404)3.68554409
10Reduced antithrombin III activity (HP:0001976)3.55550877
11Medial flaring of the eyebrow (HP:0010747)3.50112030
12Cerebral edema (HP:0002181)3.49568550
13Hypothermia (HP:0002045)3.48979102
14Conjugated hyperbilirubinemia (HP:0002908)3.48081601
15Generalized aminoaciduria (HP:0002909)3.45777896
16Molar tooth sign on MRI (HP:0002419)3.44990875
17Abnormality of midbrain morphology (HP:0002418)3.44990875
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.44056769
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.44056769
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43204132
21Type I transferrin isoform profile (HP:0003642)3.42479434
22Hypochromic microcytic anemia (HP:0004840)3.38460670
23Pancreatic cysts (HP:0001737)3.24603186
24Intrahepatic cholestasis (HP:0001406)3.18958472
25Hypoglycemic coma (HP:0001325)3.18602961
26Increased serum lactate (HP:0002151)3.11452208
27Abnormality of glycolysis (HP:0004366)3.10099660
28Increased serum pyruvate (HP:0003542)3.10099660
29Lipid accumulation in hepatocytes (HP:0006561)3.07886035
30Hypoglycemic seizures (HP:0002173)3.07198381
31Lactic acidosis (HP:0003128)3.00484220
32Abnormality of the intrinsic pathway (HP:0010989)2.96022543
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.90734504
34Hypobetalipoproteinemia (HP:0003563)2.88581422
35Increased hepatocellular lipid droplets (HP:0006565)2.84118605
36Exercise intolerance (HP:0003546)2.83868843
37Congenital primary aphakia (HP:0007707)2.80294957
38Metaphyseal dysplasia (HP:0100255)2.80070210
39Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.79143037
40Abnormal protein N-linked glycosylation (HP:0012347)2.79143037
41Abnormal protein glycosylation (HP:0012346)2.79143037
42Abnormal glycosylation (HP:0012345)2.79143037
43Nephronophthisis (HP:0000090)2.78543929
44Prolonged partial thromboplastin time (HP:0003645)2.78147138
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77839656
46Gait imbalance (HP:0002141)2.77071653
47Renal cortical cysts (HP:0000803)2.76428695
48Methylmalonic acidemia (HP:0002912)2.71528332
49Nephrogenic diabetes insipidus (HP:0009806)2.67098972
50Glycosuria (HP:0003076)2.61435798
51Abnormality of urine glucose concentration (HP:0011016)2.61435798
52Renal Fanconi syndrome (HP:0001994)2.59205502
53Hypoproteinemia (HP:0003075)2.56223575
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54664637
55Abnormality of alanine metabolism (HP:0010916)2.54664637
56Hyperalaninemia (HP:0003348)2.54664637
57Short tibia (HP:0005736)2.53808983
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52599565
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.50771246
60Ragged-red muscle fibers (HP:0003200)2.49631423
61Abnormality of fatty-acid metabolism (HP:0004359)2.48205768
62Lethargy (HP:0001254)2.46863675
63Symptomatic seizures (HP:0011145)2.45610121
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.45403744
65Respiratory failure (HP:0002878)2.45062372
66Congenital stationary night blindness (HP:0007642)2.40194257
673-Methylglutaconic aciduria (HP:0003535)2.37036130
68Amyotrophic lateral sclerosis (HP:0007354)2.34322697
69Genital tract atresia (HP:0001827)2.33296618
70Abnormality of the renal medulla (HP:0100957)2.32194569
71Fat malabsorption (HP:0002630)2.31351078
72Bile duct proliferation (HP:0001408)2.30133716
73Abnormal biliary tract physiology (HP:0012439)2.30133716
74Hypoplasia of the pons (HP:0012110)2.28567262
75Abnormality of the renal cortex (HP:0011035)2.27225245
76Hyperphosphaturia (HP:0003109)2.24402168
77Abnormality of macular pigmentation (HP:0008002)2.23057446
78Hyperbilirubinemia (HP:0002904)2.22562511
79Birth length less than 3rd percentile (HP:0003561)2.19452013
80Exertional dyspnea (HP:0002875)2.18226311
81Absent speech (HP:0001344)2.18191416
82Large for gestational age (HP:0001520)2.18029814
83Dysdiadochokinesis (HP:0002075)2.16540488
84Congenital, generalized hypertrichosis (HP:0004540)2.13168596
85Abolished electroretinogram (ERG) (HP:0000550)2.13121322
86Enlarged kidneys (HP:0000105)2.12765097
87Thyroiditis (HP:0100646)2.12458871
88Vaginal atresia (HP:0000148)2.12283356
89Opisthotonus (HP:0002179)2.12278865
90Increased intramyocellular lipid droplets (HP:0012240)2.11628732
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.11127165
92Type 2 muscle fiber atrophy (HP:0003554)2.10721103
93Abnormality of renal resorption (HP:0011038)2.09522626
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09445667
95Dicarboxylic aciduria (HP:0003215)2.09445667
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09065419
97Abnormal rod and cone electroretinograms (HP:0008323)2.08688538
98Hyperglycinemia (HP:0002154)2.08583004
99Abnormality of vitamin B metabolism (HP:0004340)2.08184521
100Increased muscle lipid content (HP:0009058)2.08008216
101Volvulus (HP:0002580)2.07563042
102Cerebral palsy (HP:0100021)2.06976168
103Brushfield spots (HP:0001088)2.05801658
104Alveolar cell carcinoma (HP:0006519)2.05646916
105Microvesicular hepatic steatosis (HP:0001414)2.05571230
106Proximal tubulopathy (HP:0000114)2.05157340
107Gaze-evoked nystagmus (HP:0000640)2.03872034
108Methylmalonic aciduria (HP:0012120)2.03706029
109Male pseudohermaphroditism (HP:0000037)2.02520117
110Steatorrhea (HP:0002570)2.00872930
111Respiratory difficulties (HP:0002880)2.00651046
112Neoplasm of the adrenal gland (HP:0100631)2.00499242
113Epiphyseal stippling (HP:0010655)1.98153947
114Limb dystonia (HP:0002451)1.98115258
115Abnormality of pyrimidine metabolism (HP:0004353)1.97456350
116Optic disc pallor (HP:0000543)1.95068448
117Leukodystrophy (HP:0002415)1.94727364
118Muscle fiber atrophy (HP:0100295)1.92802152
119Abnormal pancreas size (HP:0012094)1.92413042
120Optic nerve coloboma (HP:0000588)1.92225625
121Hyperammonemia (HP:0001987)1.91455830
122Ketoacidosis (HP:0001993)1.91090723
123Constricted visual fields (HP:0001133)1.90668898
124Attenuation of retinal blood vessels (HP:0007843)1.90513702
125Hyperventilation (HP:0002883)1.90001791
126Redundant skin (HP:0001582)1.89836311
127Atrophy/Degeneration involving motor neurons (HP:0007373)1.89806965
128Median cleft lip (HP:0000161)1.89523988
129Cystic liver disease (HP:0006706)1.89513155
130True hermaphroditism (HP:0010459)1.88708583
131Absent/shortened dynein arms (HP:0200106)1.88097849
132Dynein arm defect of respiratory motile cilia (HP:0012255)1.88097849
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.88097108
134Metabolic acidosis (HP:0001942)1.87577012
135Furrowed tongue (HP:0000221)1.87136790
136Abnormality of the pons (HP:0007361)1.86965890
137Renal tubular dysfunction (HP:0000124)1.86712648
138Postaxial foot polydactyly (HP:0001830)1.85031223
139Vomiting (HP:0002013)1.84569958
140Abnormality of the common coagulation pathway (HP:0010990)1.84391771
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.83730192
142Sclerocornea (HP:0000647)1.83530350
143Tubulointerstitial nephritis (HP:0001970)1.82645109
144Decreased circulating renin level (HP:0003351)1.80078821
145Abnormal respiratory motile cilium physiology (HP:0012261)1.79970575
146Hyperinsulinemic hypoglycemia (HP:0000825)1.79467718
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76740175
148Postaxial hand polydactyly (HP:0001162)1.76015291
149CNS demyelination (HP:0007305)1.75067197
150Congenital hepatic fibrosis (HP:0002612)1.74262077
151Thyroid-stimulating hormone excess (HP:0002925)1.73080851
152Occipital encephalocele (HP:0002085)1.70550140
153Female pseudohermaphroditism (HP:0010458)1.69648715
154Rhinitis (HP:0012384)1.68979152
155Pancreatic fibrosis (HP:0100732)1.68692139
156Ketosis (HP:0001946)1.68450802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM282.97568018
2STK162.96047826
3BCKDK2.62099383
4CDK82.59377152
5BMPR1B2.54272898
6MAP3K122.47459414
7FRK2.44481101
8TSSK62.41850557
9SIK32.41544259
10MYLK2.40877319
11CCNB12.37837116
12MAP4K22.29310187
13VRK12.23755070
14MAP3K42.19692753
15EIF2AK12.19058930
16ACVR1B2.16063278
17PASK2.12213577
18NME22.06415406
19EIF2AK32.03245363
20TGFBR11.90127855
21ERBB31.85776461
22CASK1.79112462
23GRK11.76836545
24BUB11.67378686
25TEC1.52676645
26BMPR21.51103273
27PLK21.49782951
28KDR1.48775901
29AKT31.48045721
30CSNK1G21.47308660
31ZAK1.46679774
32BCR1.41591957
33PLK41.41533430
34WEE11.40098862
35MUSK1.40054390
36SRPK11.38029296
37MKNK11.29261585
38BRSK21.23283603
39INSRR1.21761780
40OXSR11.21401562
41PIK3CG1.20157595
42BRAF1.18165464
43TIE11.17555260
44TESK11.16900046
45FLT31.15421306
46PAK31.15106304
47MST41.14596225
48PLK31.14588373
49PDK21.12629451
50WNK31.05726408
51PIK3CA1.04738554
52PINK11.03639761
53STK391.00505449
54CDC70.95388199
55NEK10.93018393
56MAP3K60.89867966
57TNIK0.87233356
58NEK60.86832525
59DAPK10.86302788
60NME10.85542434
61EIF2AK20.84849630
62MAP2K30.83610786
63RPS6KA40.81835322
64EPHA40.80900275
65TAOK20.80769625
66PAK40.80581303
67MAP2K70.79267279
68PIM20.78352573
69MAPK150.75173661
70MAP2K40.74633770
71MAP3K140.74614340
72SIK10.72709607
73EPHA30.71597963
74OBSCN0.69230251
75NUAK10.69215691
76CSNK1G30.68816050
77STK38L0.66456807
78ADRBK20.65809286
79YES10.64615999
80FER0.63986708
81ERN10.63526161
82TTK0.62058290
83ATR0.61980022
84RPS6KB20.60470780
85BTK0.60103242
86CSNK1G10.58666961
87DYRK20.58424084
88FES0.58258132
89PNCK0.58178845
90SCYL20.58001669
91GRK70.57744261
92CSNK2A10.57589776
93LIMK10.56899012
94CSF1R0.56515620
95CDK70.56260542
96EPHB20.55436776
97NLK0.54906386
98CAMK2A0.54079869
99AURKB0.54015138
100CLK10.53521195
101STK30.53259905
102ADRBK10.53216561
103LYN0.53025107
104KIT0.52353499
105PRKCG0.50791558
106KSR10.50620607
107SGK20.50454509
108ABL20.49909045
109IKBKE0.49741968
110TNK20.49605701
111ABL10.49184756
112MAPK130.45913315
113MINK10.45157257
114MATK0.44464752
115MARK10.43934168
116TLK10.43574278
117RAF10.42597459
118UHMK10.41777590
119GRK60.41087291
120PLK10.40514026
121DYRK1A0.40419973
122EGFR0.39398554
123PRKACA0.38552168
124IGF1R0.38186474
125PRKG10.37915499
126TYK20.37495294
127CDK30.37178254
128GRK50.37069171
129CAMK2D0.37048352
130PRKACB0.36895545
131TXK0.35828169
132TAOK30.35310207
133MAPK70.34566167
134CSNK2A20.34304245
135MAP3K50.33792757
136MST1R0.32871465
137MAPKAPK50.32688257
138CAMKK20.32479794
139PRKCE0.31995647
140CDK190.31923100
141TRPM70.31896782
142ITK0.31845247
143CSNK1A1L0.31742565
144MAP2K60.31588854
145PRKG20.31459084
146PRKCA0.31247094
147PRKCQ0.30825741
148ARAF0.29538695

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.82589028
2Sulfur metabolism_Homo sapiens_hsa009202.96839900
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.82159540
4Proteasome_Homo sapiens_hsa030502.79165942
5DNA replication_Homo sapiens_hsa030302.60362028
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.24921557
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11600939
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09076760
9Drug metabolism - other enzymes_Homo sapiens_hsa009832.07730221
10Oxidative phosphorylation_Homo sapiens_hsa001902.06707194
11Pyrimidine metabolism_Homo sapiens_hsa002402.02718123
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.94542345
13Mismatch repair_Homo sapiens_hsa034301.94326287
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92509434
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85814159
16Ribosome_Homo sapiens_hsa030101.83243284
17RNA polymerase_Homo sapiens_hsa030201.81806769
18Parkinsons disease_Homo sapiens_hsa050121.78144539
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70248016
20Propanoate metabolism_Homo sapiens_hsa006401.68597104
21Asthma_Homo sapiens_hsa053101.67704407
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67544348
23Tryptophan metabolism_Homo sapiens_hsa003801.65262102
24Peroxisome_Homo sapiens_hsa041461.61664540
25Folate biosynthesis_Homo sapiens_hsa007901.59188519
26Histidine metabolism_Homo sapiens_hsa003401.57880774
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53089070
28Pyruvate metabolism_Homo sapiens_hsa006201.52900310
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52072421
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49311620
31Chemical carcinogenesis_Homo sapiens_hsa052041.45976980
32Phototransduction_Homo sapiens_hsa047441.45456026
33Regulation of autophagy_Homo sapiens_hsa041401.45303787
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.44789037
35Base excision repair_Homo sapiens_hsa034101.44548090
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.44174809
37Graft-versus-host disease_Homo sapiens_hsa053321.38041064
38Nucleotide excision repair_Homo sapiens_hsa034201.37165096
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37027449
40Fatty acid elongation_Homo sapiens_hsa000621.36982746
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35803228
42Selenocompound metabolism_Homo sapiens_hsa004501.32701142
43One carbon pool by folate_Homo sapiens_hsa006701.31931389
44Glutathione metabolism_Homo sapiens_hsa004801.31665007
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26645483
46Fatty acid degradation_Homo sapiens_hsa000711.26494012
47Homologous recombination_Homo sapiens_hsa034401.26220012
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25315525
49Linoleic acid metabolism_Homo sapiens_hsa005911.23370515
50Nitrogen metabolism_Homo sapiens_hsa009101.20044899
51Autoimmune thyroid disease_Homo sapiens_hsa053201.19581066
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.19527105
53Allograft rejection_Homo sapiens_hsa053301.17951717
54Tyrosine metabolism_Homo sapiens_hsa003501.16945155
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15898049
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14846962
57Rheumatoid arthritis_Homo sapiens_hsa053231.14578628
58Alzheimers disease_Homo sapiens_hsa050101.14126361
59Huntingtons disease_Homo sapiens_hsa050161.13870339
60Non-homologous end-joining_Homo sapiens_hsa034501.13133027
61Phenylalanine metabolism_Homo sapiens_hsa003601.11461521
62Vibrio cholerae infection_Homo sapiens_hsa051101.08327707
63N-Glycan biosynthesis_Homo sapiens_hsa005101.06711406
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.06521288
65Purine metabolism_Homo sapiens_hsa002301.05702446
66beta-Alanine metabolism_Homo sapiens_hsa004101.04542491
67Butanoate metabolism_Homo sapiens_hsa006501.03840604
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03742488
69Spliceosome_Homo sapiens_hsa030401.01121537
70SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00125533
71Starch and sucrose metabolism_Homo sapiens_hsa005000.94521372
72Retinol metabolism_Homo sapiens_hsa008300.94422570
73RNA degradation_Homo sapiens_hsa030180.94154649
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91730123
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91047603
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90346987
77Ether lipid metabolism_Homo sapiens_hsa005650.89470299
78Galactose metabolism_Homo sapiens_hsa000520.87942839
79Metabolic pathways_Homo sapiens_hsa011000.85795303
80Nicotine addiction_Homo sapiens_hsa050330.85579066
81Arginine and proline metabolism_Homo sapiens_hsa003300.85411636
82Cell cycle_Homo sapiens_hsa041100.84128033
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83569165
84Caffeine metabolism_Homo sapiens_hsa002320.82909114
85Carbon metabolism_Homo sapiens_hsa012000.81495245
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77976315
87Sulfur relay system_Homo sapiens_hsa041220.77732360
88Complement and coagulation cascades_Homo sapiens_hsa046100.76916094
89Cardiac muscle contraction_Homo sapiens_hsa042600.75542245
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73579186
91Olfactory transduction_Homo sapiens_hsa047400.72046051
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70964231
93Fatty acid metabolism_Homo sapiens_hsa012120.69957177
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69836524
95Synaptic vesicle cycle_Homo sapiens_hsa047210.68092898
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66531980
97RNA transport_Homo sapiens_hsa030130.65239734
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62704809
99GABAergic synapse_Homo sapiens_hsa047270.60363650
100Biosynthesis of amino acids_Homo sapiens_hsa012300.58363297
101Antigen processing and presentation_Homo sapiens_hsa046120.58198186
102Circadian rhythm_Homo sapiens_hsa047100.55918794
103Mineral absorption_Homo sapiens_hsa049780.55898663
104Insulin secretion_Homo sapiens_hsa049110.54027640
105Taste transduction_Homo sapiens_hsa047420.52828358
106Dopaminergic synapse_Homo sapiens_hsa047280.52794173
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52007577
108Basal transcription factors_Homo sapiens_hsa030220.51011662
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49956090
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49149994
111Arachidonic acid metabolism_Homo sapiens_hsa005900.47072992
112Oocyte meiosis_Homo sapiens_hsa041140.46853278
113Phagosome_Homo sapiens_hsa041450.46670492
114Thyroid cancer_Homo sapiens_hsa052160.46299660
115Hematopoietic cell lineage_Homo sapiens_hsa046400.45321374
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45142253
117Renin secretion_Homo sapiens_hsa049240.44364526
118Legionellosis_Homo sapiens_hsa051340.43484467
119Sphingolipid metabolism_Homo sapiens_hsa006000.42201681
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41981911
121Staphylococcus aureus infection_Homo sapiens_hsa051500.41864447
122Fanconi anemia pathway_Homo sapiens_hsa034600.40715022
123Circadian entrainment_Homo sapiens_hsa047130.40592650
124Amphetamine addiction_Homo sapiens_hsa050310.40478453
125Morphine addiction_Homo sapiens_hsa050320.39552459
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38651505
127Salivary secretion_Homo sapiens_hsa049700.38450674
128Serotonergic synapse_Homo sapiens_hsa047260.38204525
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34330957
130Collecting duct acid secretion_Homo sapiens_hsa049660.28046988
131Pentose phosphate pathway_Homo sapiens_hsa000300.27852973
132Steroid biosynthesis_Homo sapiens_hsa001000.27223831
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.19383249
134ABC transporters_Homo sapiens_hsa020100.17779899
135PPAR signaling pathway_Homo sapiens_hsa033200.16730409
136Vitamin digestion and absorption_Homo sapiens_hsa049770.16451620
137Type I diabetes mellitus_Homo sapiens_hsa049400.15728880
138Other glycan degradation_Homo sapiens_hsa005110.11636083
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.11489894
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11202005

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