SLC35A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.58539878
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.52136517
3L-phenylalanine catabolic process (GO:0006559)5.14952634
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.14952634
5aromatic amino acid family catabolic process (GO:0009074)4.96316532
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.94138111
7L-phenylalanine metabolic process (GO:0006558)4.94138111
8axonemal dynein complex assembly (GO:0070286)4.93610435
9tryptophan catabolic process (GO:0006569)4.87539010
10indole-containing compound catabolic process (GO:0042436)4.87539010
11indolalkylamine catabolic process (GO:0046218)4.87539010
12cilium movement (GO:0003341)4.82237886
13sulfur amino acid catabolic process (GO:0000098)4.73178891
14tryptophan metabolic process (GO:0006568)4.72232347
15cysteine metabolic process (GO:0006534)4.70243363
16urea metabolic process (GO:0019627)4.66195763
17urea cycle (GO:0000050)4.66195763
18epithelial cilium movement (GO:0003351)4.64659250
19homocysteine metabolic process (GO:0050667)4.58746921
20kynurenine metabolic process (GO:0070189)4.53967435
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.45900000
22axoneme assembly (GO:0035082)4.42428804
23bile acid and bile salt transport (GO:0015721)4.27526412
24lysine catabolic process (GO:0006554)4.23892805
25lysine metabolic process (GO:0006553)4.23892805
26bile acid biosynthetic process (GO:0006699)4.22368773
27fucose catabolic process (GO:0019317)4.22095459
28L-fucose metabolic process (GO:0042354)4.22095459
29L-fucose catabolic process (GO:0042355)4.22095459
30cellular glucuronidation (GO:0052695)4.18509452
31glyoxylate metabolic process (GO:0046487)4.16983143
32negative regulation of sterol transport (GO:0032372)4.15694410
33negative regulation of cholesterol transport (GO:0032375)4.15694410
34nitrogen cycle metabolic process (GO:0071941)4.14034080
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12891164
36high-density lipoprotein particle remodeling (GO:0034375)4.09143168
37alpha-linolenic acid metabolic process (GO:0036109)4.07995535
38drug transmembrane transport (GO:0006855)4.04419145
39protein carboxylation (GO:0018214)4.04159061
40peptidyl-glutamic acid carboxylation (GO:0017187)4.04159061
41bile acid metabolic process (GO:0008206)4.04002064
42drug catabolic process (GO:0042737)4.02178172
43behavioral response to nicotine (GO:0035095)4.00627018
44intestinal cholesterol absorption (GO:0030299)3.92459204
45serine family amino acid catabolic process (GO:0009071)3.86753901
46amino-acid betaine metabolic process (GO:0006577)3.86269769
47intestinal absorption (GO:0050892)3.81583950
48reverse cholesterol transport (GO:0043691)3.81244926
49complement activation, alternative pathway (GO:0006957)3.80702478
50sulfation (GO:0051923)3.77822564
51urate metabolic process (GO:0046415)3.75031077
52regulation of protein activation cascade (GO:2000257)3.73719120
53uronic acid metabolic process (GO:0006063)3.73048345
54glucuronate metabolic process (GO:0019585)3.73048345
55kidney morphogenesis (GO:0060993)3.72953053
56regulation of triglyceride catabolic process (GO:0010896)3.68455131
57protein-lipid complex remodeling (GO:0034368)3.66107653
58macromolecular complex remodeling (GO:0034367)3.66107653
59plasma lipoprotein particle remodeling (GO:0034369)3.66107653
60phospholipid efflux (GO:0033700)3.65617473
61valine metabolic process (GO:0006573)3.65124250
62aromatic amino acid family metabolic process (GO:0009072)3.63947170
63drug transport (GO:0015893)3.57007014
64indolalkylamine metabolic process (GO:0006586)3.54410201
653-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.53198520
66purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.53198520
67regulation of complement activation (GO:0030449)3.53069338
68cellular modified amino acid catabolic process (GO:0042219)3.49031354
69sulfate transmembrane transport (GO:1902358)3.48914846
70response to nitrosative stress (GO:0051409)3.46374261
71flavonoid metabolic process (GO:0009812)3.46060320
72phospholipid homeostasis (GO:0055091)3.45695689
73regulation of bile acid biosynthetic process (GO:0070857)3.45681786
74benzene-containing compound metabolic process (GO:0042537)3.43849384
75neural tube formation (GO:0001841)3.43056247
76plasma lipoprotein particle assembly (GO:0034377)3.40087520
77acylglycerol homeostasis (GO:0055090)3.39412950
78triglyceride homeostasis (GO:0070328)3.39412950
79negative regulation of fibrinolysis (GO:0051918)3.37971261
80oxidative demethylation (GO:0070989)3.37369504
81exogenous drug catabolic process (GO:0042738)3.36834520
82regulation of hippo signaling (GO:0035330)3.35733735
83regulation of cholesterol homeostasis (GO:2000188)3.32869074
84cholesterol efflux (GO:0033344)3.32778107
85alpha-amino acid catabolic process (GO:1901606)3.31738515
86motile cilium assembly (GO:0044458)3.30647253
87tyrosine metabolic process (GO:0006570)3.30005227
88thyroid hormone metabolic process (GO:0042403)3.29849171
89regulation of cholesterol esterification (GO:0010872)3.29479208
90serine family amino acid metabolic process (GO:0009069)3.29271027
91regulation of fibrinolysis (GO:0051917)3.28810509
92lipoprotein metabolic process (GO:0042157)3.26577982
93ethanol oxidation (GO:0006069)3.24708151
94cellular biogenic amine catabolic process (GO:0042402)3.22896347
95amine catabolic process (GO:0009310)3.22896347
96sterol homeostasis (GO:0055092)3.21299051
97cholesterol homeostasis (GO:0042632)3.19339490
98very-low-density lipoprotein particle assembly (GO:0034379)3.17874054
99cellular amino acid catabolic process (GO:0009063)3.15533509
100plasma lipoprotein particle clearance (GO:0034381)3.15227371
101glycine metabolic process (GO:0006544)3.14877465
102rRNA catabolic process (GO:0016075)3.13559265
103protein-lipid complex assembly (GO:0065005)3.11446047
104intestinal epithelial cell development (GO:0060576)3.08803766
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05938899
106serine family amino acid biosynthetic process (GO:0009070)3.05684390
107plasma lipoprotein particle organization (GO:0071827)3.05065142
108short-chain fatty acid metabolic process (GO:0046459)3.04748225
109xenobiotic catabolic process (GO:0042178)3.03134659
110photoreceptor cell maintenance (GO:0045494)3.01436550
111* UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01388301
112fatty acid oxidation (GO:0019395)3.00449888
113sulfate transport (GO:0008272)2.98893816
114epoxygenase P450 pathway (GO:0019373)2.98773758
115low-density lipoprotein particle remodeling (GO:0034374)2.98424228
116hormone catabolic process (GO:0042447)2.98393163
117positive regulation of fatty acid oxidation (GO:0046321)2.96801473
118carnitine metabolic process (GO:0009437)2.96471308
119lipid oxidation (GO:0034440)2.95921609
120cilium organization (GO:0044782)2.95167821
121drug metabolic process (GO:0017144)2.93749780
122ketone body metabolic process (GO:1902224)2.93351095
123positive regulation of lipid catabolic process (GO:0050996)2.93070801
124glutamate metabolic process (GO:0006536)2.92210293
125protein-lipid complex subunit organization (GO:0071825)2.90694118
126regulation of mesoderm development (GO:2000380)2.90688375
127coenzyme catabolic process (GO:0009109)2.88927372
128fatty acid beta-oxidation (GO:0006635)2.88699834
129cellular ketone body metabolic process (GO:0046950)2.87542042
130regulation of guanylate cyclase activity (GO:0031282)2.86804330
131cilium assembly (GO:0042384)2.85584177
1322-oxoglutarate metabolic process (GO:0006103)2.85334768
133somite rostral/caudal axis specification (GO:0032525)2.85036683
134positive regulation of fatty acid beta-oxidation (GO:0032000)2.81773609
135detection of light stimulus involved in sensory perception (GO:0050962)2.80449848
136detection of light stimulus involved in visual perception (GO:0050908)2.80449848
137fucosylation (GO:0036065)2.78617591
138regulation of pigment cell differentiation (GO:0050932)2.77842828
139vitamin transmembrane transport (GO:0035461)2.77545772
140reflex (GO:0060004)2.75581374
141alkaloid metabolic process (GO:0009820)2.73339843
142signal transduction involved in regulation of gene expression (GO:0023019)2.72202548
143cilium morphogenesis (GO:0060271)2.71597366
144transepithelial transport (GO:0070633)2.69549455
145indole-containing compound metabolic process (GO:0042430)2.68280376
146negative regulation of sodium ion transport (GO:0010766)2.64472758
147oligosaccharide biosynthetic process (GO:0009312)2.63798347
148negative regulation of systemic arterial blood pressure (GO:0003085)2.63576634
149cornea development in camera-type eye (GO:0061303)2.63569037
150interkinetic nuclear migration (GO:0022027)2.61550531
151response to pheromone (GO:0019236)2.61157193
152behavioral response to ethanol (GO:0048149)2.59349672
153regulation of cilium movement (GO:0003352)2.56084837
154negative regulation of T cell differentiation in thymus (GO:0033085)2.55560977
155somite development (GO:0061053)2.54192635
156endoderm formation (GO:0001706)2.53882960
157establishment of protein localization to Golgi (GO:0072600)2.52965153
158positive regulation of guanylate cyclase activity (GO:0031284)2.49404181
159positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49078959
160lipid translocation (GO:0034204)2.48831480
161phospholipid translocation (GO:0045332)2.48831480
162arginine metabolic process (GO:0006525)2.48805702
163bicarbonate transport (GO:0015701)2.48550942
164digestion (GO:0007586)2.46349584
165primary alcohol catabolic process (GO:0034310)2.46014057
166retinoic acid metabolic process (GO:0042573)2.43937000
167sulfur compound transport (GO:0072348)2.43726091
168thyroid hormone generation (GO:0006590)2.43634856
169water-soluble vitamin biosynthetic process (GO:0042364)2.43633833
170left/right axis specification (GO:0070986)2.43356472
171intraciliary transport (GO:0042073)2.42320593
172neuronal action potential (GO:0019228)2.40948611
173ethanol metabolic process (GO:0006067)2.39060855
174phosphatidylserine acyl-chain remodeling (GO:0036150)2.38118981
175embryonic epithelial tube formation (GO:0001838)2.37904079
176cellular response to sterol (GO:0036315)2.37316472
177phenol-containing compound catabolic process (GO:0019336)2.36764531
178positive regulation of fatty acid transport (GO:2000193)2.36482630

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.87235702
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.87289133
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.22231061
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.14129519
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.85721244
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.31369158
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.20595120
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.01493057
9VDR_22108803_ChIP-Seq_LS180_Human2.98333395
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.89619038
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.86856399
12ZNF274_21170338_ChIP-Seq_K562_Hela2.86517923
13GATA1_22025678_ChIP-Seq_K562_Human2.79428945
14* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.57799171
15GBX2_23144817_ChIP-Seq_PC3_Human2.57657769
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54924523
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53189718
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.51895129
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42042245
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.34989247
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.33879182
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25608108
23IGF1R_20145208_ChIP-Seq_DFB_Human2.20742613
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.15397866
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10042468
26TAF15_26573619_Chip-Seq_HEK293_Human2.08170421
27FUS_26573619_Chip-Seq_HEK293_Human2.08020360
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.06678136
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.06591267
30TP63_17297297_ChIP-ChIP_HaCaT_Human2.04410211
31EWS_26573619_Chip-Seq_HEK293_Human2.04350835
32* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.03072217
33GATA4_25053715_ChIP-Seq_YYC3_Human2.01864553
34ER_23166858_ChIP-Seq_MCF-7_Human1.99532808
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99506201
36P300_19829295_ChIP-Seq_ESCs_Human1.93338135
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90198479
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.90198031
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86761547
40* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81178458
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80715351
42BCAT_22108803_ChIP-Seq_LS180_Human1.78067635
43NR3C1_21868756_ChIP-Seq_MCF10A_Human1.75661856
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74071977
45STAT3_23295773_ChIP-Seq_U87_Human1.71981660
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69591806
47CLOCK_20551151_ChIP-Seq_293T_Human1.69323489
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.67430304
49SMAD4_21799915_ChIP-Seq_A2780_Human1.65456710
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.64220417
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62610695
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61896749
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61446651
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59372887
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58005036
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55400186
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55247643
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.55030941
59FOXA2_19822575_ChIP-Seq_HepG2_Human1.54502381
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.54411100
61* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54103132
62AHR_22903824_ChIP-Seq_MCF-7_Human1.52822694
63GATA6_25053715_ChIP-Seq_YYC3_Human1.52732463
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50513300
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50332451
66CBP_20019798_ChIP-Seq_JUKART_Human1.50332451
67TCF4_22108803_ChIP-Seq_LS180_Human1.48250944
68TCF4_23295773_ChIP-Seq_U87_Human1.47547875
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47526858
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.47078965
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46340537
72* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46234379
73SOX2_20726797_ChIP-Seq_SW620_Human1.46119431
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44599665
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44190244
76AR_25329375_ChIP-Seq_VCAP_Human1.43676606
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42410095
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41691785
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41549611
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39432396
81TP53_16413492_ChIP-PET_HCT116_Human1.38826051
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.38155721
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34156739
84* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.34095268
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33910438
86* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33799836
87AR_21909140_ChIP-Seq_LNCAP_Human1.32462607
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31467742
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30967160
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.28948863
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.28097172
92RUNX2_22187159_ChIP-Seq_PCA_Human1.28089614
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25219177
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25217942
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24126179
96STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23734002
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23670201
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.23566203
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23322782
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22806495
101IRF1_19129219_ChIP-ChIP_H3396_Human1.22650033
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22480181
103NANOG_19829295_ChIP-Seq_ESCs_Human1.22208205
104SOX2_19829295_ChIP-Seq_ESCs_Human1.22208205
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.20067003
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.19887045
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19508313
108AR_21572438_ChIP-Seq_LNCaP_Human1.18615916
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17198003
110* FOXA1_25329375_ChIP-Seq_VCAP_Human1.15312240
111* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15312240
112P53_22387025_ChIP-Seq_ESCs_Mouse1.14133211
113EZH2_22144423_ChIP-Seq_EOC_Human1.14122811
114* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12675199
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12596023
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12346048
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11969946
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11836863
119* SMAD3_21741376_ChIP-Seq_HESCs_Human1.11794543
120GATA2_21666600_ChIP-Seq_HMVEC_Human1.11368684
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10516287
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09271493
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08833773
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.08640506
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.08574305
126RXR_22108803_ChIP-Seq_LS180_Human1.08085883
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07161730
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07161730
129SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06771796
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.05976698
131FOXA1_25552417_ChIP-Seq_VCAP_Human1.05710519
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05696165
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05696165
134ESR1_20079471_ChIP-ChIP_T-47D_Human1.04890019
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.04397885
136CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04281294
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04250461
138NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04250461
139TP53_22573176_ChIP-Seq_HFKS_Human1.03044712
140* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96549045
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95286869
142MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95192874
143VDR_24787735_ChIP-Seq_THP-1_Human0.94798422
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94506936
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94320674
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93809659
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93056265
148CDX2_22108803_ChIP-Seq_LS180_Human0.92887413
149BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92520186
150GATA2_19941826_ChIP-Seq_K562_Human0.91865040
151RUNX_20019798_ChIP-Seq_JUKART_Human0.89686665
152PU_27001747_Chip-Seq_BMDM_Mouse0.89027041
153TRIM28_21343339_ChIP-Seq_HEK293_Human0.85454773
154* GATA3_24758297_ChIP-Seq_MCF-7_Human0.85219624
155CJUN_26792858_Chip-Seq_BT549_Human0.85087913
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84376319
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82589167
158CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80304694
159SCL_19346495_ChIP-Seq_HPC-7_Human0.80108128
160EGR1_19374776_ChIP-ChIP_THP-1_Human0.78430845
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77158254
162* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.76879382
163* MYB_26560356_Chip-Seq_TH1_Human0.75923745
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75911757
165CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.75288471
166RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74668113
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.74414416
168HTT_18923047_ChIP-ChIP_STHdh_Human0.73592513
169AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73213259
170TP63_23658742_ChIP-Seq_EP156T_Human0.71933014
171PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71522144
172MYB_26560356_Chip-Seq_TH2_Human0.69899361
173EZH2_27294783_Chip-Seq_NPCs_Mouse0.69352568
174PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69092281
175BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.68860231
176TCF4_18268006_ChIP-ChIP_LS174T_Human0.68305620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.33466777
2MP0002139_abnormal_hepatobiliary_system5.90322390
3MP0005085_abnormal_gallbladder_physiolo4.85380077
4MP0005365_abnormal_bile_salt4.80297456
5MP0008875_abnormal_xenobiotic_pharmacok3.98183583
6MP0003252_abnormal_bile_duct3.63829112
7MP0000569_abnormal_digit_pigmentation3.00144485
8MP0001666_abnormal_nutrient_absorption2.98771557
9MP0003890_abnormal_embryonic-extraembry2.92801650
10MP0003806_abnormal_nucleotide_metabolis2.88849308
11MP0010329_abnormal_lipoprotein_level2.65499963
12MP0010234_abnormal_vibrissa_follicle2.41078277
13MP0009840_abnormal_foam_cell2.21798543
14MP0003300_gastrointestinal_ulcer2.21036611
15MP0002138_abnormal_hepatobiliary_system2.13045251
16MP0005332_abnormal_amino_acid2.12369517
17MP0004019_abnormal_vitamin_homeostasis2.11103196
18MP0008872_abnormal_physiological_respon2.03550112
19MP0005551_abnormal_eye_electrophysiolog2.01638834
20MP0003868_abnormal_feces_composition1.95714285
21MP0003191_abnormal_cellular_cholesterol1.94275959
22MP0005083_abnormal_biliary_tract1.86199703
23MP0003195_calcinosis1.83796580
24MP0000609_abnormal_liver_physiology1.80569077
25MP0001485_abnormal_pinna_reflex1.79158370
26MP0004264_abnormal_extraembryonic_tissu1.75163987
27MP0001664_abnormal_digestion1.73972258
28MP0004133_heterotaxia1.64047141
29MP0002160_abnormal_reproductive_system1.60418933
30MP0009643_abnormal_urine_homeostasis1.58733877
31MP0001873_stomach_inflammation1.54292004
32MP0003283_abnormal_digestive_organ1.52676608
33MP0008961_abnormal_basal_metabolism1.51634086
34MP0005319_abnormal_enzyme/_coenzyme1.49936153
35MP0002102_abnormal_ear_morphology1.49829208
36MP0005645_abnormal_hypothalamus_physiol1.48435589
37MP0002118_abnormal_lipid_homeostasis1.48130773
38MP0005646_abnormal_pituitary_gland1.46855105
39MP0003119_abnormal_digestive_system1.37564054
40MP0009764_decreased_sensitivity_to1.37348749
41MP0003705_abnormal_hypodermis_morpholog1.35814426
42MP0003646_muscle_fatigue1.34700767
43MP0002166_altered_tumor_susceptibility1.32119653
44MP0005389_reproductive_system_phenotype1.31383354
45MP0002277_abnormal_respiratory_mucosa1.30857403
46MP0005174_abnormal_tail_pigmentation1.30344583
47MP0010155_abnormal_intestine_physiology1.28695005
48MP0000631_abnormal_neuroendocrine_gland1.28232640
49MP0006292_abnormal_olfactory_placode1.24888973
50MP0001501_abnormal_sleep_pattern1.24635063
51MP0001764_abnormal_homeostasis1.24253827
52MP0002638_abnormal_pupillary_reflex1.21579405
53MP0008877_abnormal_DNA_methylation1.20652922
54MP0005636_abnormal_mineral_homeostasis1.17389094
55MP0009697_abnormal_copulation1.17007521
56MP0002653_abnormal_ependyma_morphology1.16198958
57MP0003436_decreased_susceptibility_to1.14843796
58MP0002938_white_spotting1.14706531
59MP0003937_abnormal_limbs/digits/tail_de1.13714446
60MP0009046_muscle_twitch1.11524752
61MP0000230_abnormal_systemic_arterial1.11425885
62MP0003186_abnormal_redox_activity1.10913158
63MP0004142_abnormal_muscle_tone1.10887153
64MP0001968_abnormal_touch/_nociception1.09805668
65MP0002837_dystrophic_cardiac_calcinosis1.09222650
66MP0002736_abnormal_nociception_after1.07359551
67MP0008469_abnormal_protein_level1.07234041
68MP0010352_gastrointestinal_tract_polyps1.05887611
69MP0005408_hypopigmentation1.05795071
70MP0005647_abnormal_sex_gland1.05081278
71MP0005220_abnormal_exocrine_pancreas1.04989847
72MP0006072_abnormal_retinal_apoptosis1.04053423
73MP0005253_abnormal_eye_physiology1.03663073
74MP0004043_abnormal_pH_regulation1.03282908
75MP0003718_maternal_effect1.03162377
76MP0003656_abnormal_erythrocyte_physiolo1.02830899
77MP0002136_abnormal_kidney_physiology1.01853374
78MP0004924_abnormal_behavior1.00878913
79MP0005386_behavior/neurological_phenoty1.00878913
80MP0003724_increased_susceptibility_to1.00539322
81MP0001756_abnormal_urination0.99237540
82MP0005584_abnormal_enzyme/coenzyme_acti0.98800862
83MP0002234_abnormal_pharynx_morphology0.98796975
84MP0000598_abnormal_liver_morphology0.98230578
85MP0000470_abnormal_stomach_morphology0.97630016
86MP0000013_abnormal_adipose_tissue0.96991830
87MP0001919_abnormal_reproductive_system0.95835150
88MP0010386_abnormal_urinary_bladder0.95609238
89MP0005464_abnormal_platelet_physiology0.95137741
90MP0002254_reproductive_system_inflammat0.94904208
91MP0004947_skin_inflammation0.94473005
92MP0009384_cardiac_valve_regurgitation0.93693328
93MP0010678_abnormal_skin_adnexa0.92642876
94MP0002006_tumorigenesis0.92347376
95MP0001835_abnormal_antigen_presentation0.91043592
96MP0002557_abnormal_social/conspecific_i0.90141174
97MP0005448_abnormal_energy_balance0.89528642
98MP0001845_abnormal_inflammatory_respons0.89176665
99MP0009780_abnormal_chondrocyte_physiolo0.88616956
100MP0009763_increased_sensitivity_to0.88357886
101MP0004885_abnormal_endolymph0.88096613
102MP0001765_abnormal_ion_homeostasis0.87963264
103MP0002272_abnormal_nervous_system0.87782794
104MP0001663_abnormal_digestive_system0.87746594
105MP0005451_abnormal_body_composition0.87415215
106MP0005195_abnormal_posterior_eye0.86025937
107MP0001984_abnormal_olfaction0.85457948
108MP0003866_abnormal_defecation0.84991537
109MP0001986_abnormal_taste_sensitivity0.84375543
110MP0003453_abnormal_keratinocyte_physiol0.84211757
111MP0005084_abnormal_gallbladder_morpholo0.84140582
112MP0009785_altered_susceptibility_to0.83734133
113MP0006054_spinal_hemorrhage0.83477106
114MP0001188_hyperpigmentation0.82297270
115MP0009745_abnormal_behavioral_response0.81890229
116MP0005058_abnormal_lysosome_morphology0.81345282
117MP0008057_abnormal_DNA_replication0.79820154
118MP0002419_abnormal_innate_immunity0.79001799
119MP0008004_abnormal_stomach_pH0.78632050
120MP0002735_abnormal_chemical_nociception0.78428935
121MP0009765_abnormal_xenobiotic_induced0.78407996
122MP0004147_increased_porphyrin_level0.78129805
123MP0000490_abnormal_crypts_of0.77114015
124MP0002909_abnormal_adrenal_gland0.77000346
125MP0005187_abnormal_penis_morphology0.76694416
126MP0002928_abnormal_bile_duct0.75966318
127MP0001881_abnormal_mammary_gland0.75896364
128MP0000647_abnormal_sebaceous_gland0.75686004
129MP0003183_abnormal_peptide_metabolism0.75183498
130MP0009642_abnormal_blood_homeostasis0.74944757
131MP0000538_abnormal_urinary_bladder0.74744308
132MP0003136_yellow_coat_color0.74111964
133MP0002009_preneoplasia0.73985827
134MP0004215_abnormal_myocardial_fiber0.73544774
135MP0000477_abnormal_intestine_morphology0.72628519
136MP0005025_abnormal_response_to0.72503831
137MP0003936_abnormal_reproductive_system0.71475457
138MP0005310_abnormal_salivary_gland0.71474297
139MP0002876_abnormal_thyroid_physiology0.71107702
140MP0004145_abnormal_muscle_electrophysio0.70813728
141MP0004782_abnormal_surfactant_physiolog0.70369058
142MP0005381_digestive/alimentary_phenotyp0.69500244
143MP0002098_abnormal_vibrissa_morphology0.68597783
144MP0000465_gastrointestinal_hemorrhage0.68506910
145MP0005166_decreased_susceptibility_to0.68348205
146MP0002060_abnormal_skin_morphology0.67992150
147MP0000566_synostosis0.67741484
148MP0008995_early_reproductive_senescence0.67417248
149MP0003953_abnormal_hormone_level0.66876159
150MP0009379_abnormal_foot_pigmentation0.66456964
151MP0000377_abnormal_hair_follicle0.64006451
152MP0006082_CNS_inflammation0.61859412
153MP0001533_abnormal_skeleton_physiology0.61434262
154MP0000383_abnormal_hair_follicle0.59690033
155MP0000427_abnormal_hair_cycle0.58394485
156MP0005334_abnormal_fat_pad0.57601987
157MP0001216_abnormal_epidermal_layer0.57391601
158MP0005023_abnormal_wound_healing0.55502610
159MP0001853_heart_inflammation0.55312874
160MP0001800_abnormal_humoral_immune0.55210363
161MP0002132_abnormal_respiratory_system0.54992567
162MP0005376_homeostasis/metabolism_phenot0.52610699
163MP0009053_abnormal_anal_canal0.52564871
164MP0000627_abnormal_mammary_gland0.52072809

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.73393709
2Abnormality of monocarboxylic acid metabolism (HP:0010996)5.05089616
3Abnormality of glutamine family amino acid metabolism (HP:0010902)4.65874491
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.61422647
5Absent/shortened dynein arms (HP:0200106)4.58838770
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.58838770
7Deep venous thrombosis (HP:0002625)4.58504713
8Pancreatic cysts (HP:0001737)4.53686435
9Xanthomatosis (HP:0000991)4.52762634
10Hypobetalipoproteinemia (HP:0003563)4.44908329
11Prolonged partial thromboplastin time (HP:0003645)4.31310274
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.27347886
13Abnormal ciliary motility (HP:0012262)4.15450457
14Pancreatic fibrosis (HP:0100732)4.10412301
15Abnormal respiratory motile cilium physiology (HP:0012261)4.10013522
16Abnormal respiratory epithelium morphology (HP:0012253)4.08473095
17Abnormal respiratory motile cilium morphology (HP:0005938)4.08473095
18Conjugated hyperbilirubinemia (HP:0002908)4.05896100
19Fat malabsorption (HP:0002630)4.05265676
20True hermaphroditism (HP:0010459)3.78566919
21Decreased circulating renin level (HP:0003351)3.76682469
22Rhinitis (HP:0012384)3.66796995
23Complement deficiency (HP:0004431)3.64020446
24Molar tooth sign on MRI (HP:0002419)3.59284046
25Abnormality of midbrain morphology (HP:0002418)3.59284046
26Epidermoid cyst (HP:0200040)3.58170562
27Abnormality of the common coagulation pathway (HP:0010990)3.56247887
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.51971828
29Joint hemorrhage (HP:0005261)3.50246858
30Hyperglycinuria (HP:0003108)3.50178384
31Abnormality of the renal cortex (HP:0011035)3.45962579
32Hypoglycemic coma (HP:0001325)3.42093976
33Hypolipoproteinemia (HP:0010981)3.39020903
34Hyperammonemia (HP:0001987)3.32488289
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30391973
36Genetic anticipation (HP:0003743)3.21661898
37Abnormality of the intrinsic pathway (HP:0010989)3.19913291
38Nephronophthisis (HP:0000090)3.19738856
39Abnormality of serine family amino acid metabolism (HP:0010894)3.18391172
40Abnormality of glycine metabolism (HP:0010895)3.18391172
41Hyperlipoproteinemia (HP:0010980)3.16140064
42Hyperglycinemia (HP:0002154)3.12104452
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09239921
44Myocardial infarction (HP:0001658)3.08851137
45Cystic liver disease (HP:0006706)3.05912868
46Acanthocytosis (HP:0001927)3.04888945
47Hyperventilation (HP:0002883)3.03641364
48Hydroxyprolinuria (HP:0003080)3.01952484
49Abnormality of proline metabolism (HP:0010907)3.01952484
50Abnormality of purine metabolism (HP:0004352)3.01049493
51Abnormality of the renal medulla (HP:0100957)3.00100843
52Ketosis (HP:0001946)2.98444021
53Abnormality of nucleobase metabolism (HP:0010932)2.98045884
54Chronic bronchitis (HP:0004469)2.97452564
55Congenital stationary night blindness (HP:0007642)2.96032814
56Esophageal varix (HP:0002040)2.93954683
57Tubular atrophy (HP:0000092)2.93926801
58Abnormality of pyrimidine metabolism (HP:0004353)2.92038666
59Hypoalphalipoproteinemia (HP:0003233)2.91199901
60Vascular calcification (HP:0004934)2.90481659
61Steatorrhea (HP:0002570)2.89861798
62Hypercholesterolemia (HP:0003124)2.86980322
63Chronic hepatic failure (HP:0100626)2.79986955
64Abnormality of renin-angiotensin system (HP:0000847)2.78576556
65Bronchiectasis (HP:0002110)2.78411700
66Abnormality of fatty-acid metabolism (HP:0004359)2.77602128
67Hepatocellular carcinoma (HP:0001402)2.74175582
68Abnormality of complement system (HP:0005339)2.74137311
69Abnormality of methionine metabolism (HP:0010901)2.70909086
70Medial flaring of the eyebrow (HP:0010747)2.68016758
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67311853
72Abnormality of alanine metabolism (HP:0010916)2.67311853
73Hyperalaninemia (HP:0003348)2.67311853
74Cardiovascular calcification (HP:0011915)2.60947120
75Metabolic alkalosis (HP:0200114)2.60409480
76Gaze-evoked nystagmus (HP:0000640)2.48545047
77Abnormality of the nasal septum (HP:0000419)2.48195106
78Protruding tongue (HP:0010808)2.48179066
79Hyperbilirubinemia (HP:0002904)2.46740784
80Hypoglycemic seizures (HP:0002173)2.46610220
81Chronic diarrhea (HP:0002028)2.46430907
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.44561022
83Congenital sensorineural hearing impairment (HP:0008527)2.43826126
84Furrowed tongue (HP:0000221)2.43006981
85Progressive cerebellar ataxia (HP:0002073)2.42652982
86Gout (HP:0001997)2.40207233
87Recurrent gram-negative bacterial infections (HP:0005420)2.38117314
88Abolished electroretinogram (ERG) (HP:0000550)2.37998650
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.35996541
90Proximal tubulopathy (HP:0000114)2.34717292
91Gingival bleeding (HP:0000225)2.32985479
92Hyperactive renin-angiotensin system (HP:0000841)2.31013407
93Systemic lupus erythematosus (HP:0002725)2.30579380
94Type II lissencephaly (HP:0007260)2.30288519
95Fair hair (HP:0002286)2.29927941
96Spastic diplegia (HP:0001264)2.29673861
97Ketoacidosis (HP:0001993)2.28946999
98Malnutrition (HP:0004395)2.28621796
99Renal cortical cysts (HP:0000803)2.28023552
100Abnormal tarsal ossification (HP:0008369)2.25674065
101Attenuation of retinal blood vessels (HP:0007843)2.22094935
102Menorrhagia (HP:0000132)2.21356461
103Glomerulonephritis (HP:0000099)2.20446801
104Metabolic acidosis (HP:0001942)2.20169427
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.20116731
106Pancreatitis (HP:0001733)2.19895913
107Cerebellar dysplasia (HP:0007033)2.19875966
108Bile duct proliferation (HP:0001408)2.19799647
109Abnormal biliary tract physiology (HP:0012439)2.19799647
110Generalized aminoaciduria (HP:0002909)2.19792339
111Congenital, generalized hypertrichosis (HP:0004540)2.19591219
112Congenital hepatic fibrosis (HP:0002612)2.18211598
113Inability to walk (HP:0002540)2.17937017
114Polydipsia (HP:0001959)2.16797030
115Abnormal drinking behavior (HP:0030082)2.16797030
116Right ventricular cardiomyopathy (HP:0011663)2.14222880
117Abdominal distention (HP:0003270)2.14126048
118Abnormal foot bone ossification (HP:0010675)2.13477303
119Abnormality of serum amino acid levels (HP:0003112)2.11995867
120Alkalosis (HP:0001948)2.11483716
121Progressive inability to walk (HP:0002505)2.11249738
122Vacuolated lymphocytes (HP:0001922)2.10489004
123Hypoplastic labia majora (HP:0000059)2.09649223
124Anencephaly (HP:0002323)2.07005537
125Gait imbalance (HP:0002141)2.06792293
126Spontaneous abortion (HP:0005268)2.04910663
127Congenital primary aphakia (HP:0007707)2.04233413
128Chorioretinal atrophy (HP:0000533)2.02215633
129Sensorimotor neuropathy (HP:0007141)2.01200735
130Hyperaldosteronism (HP:0000859)2.00171460
131Abnormal enzyme/coenzyme activity (HP:0012379)1.99913251
132Abnormality of vitamin B metabolism (HP:0004340)1.99662399
133Thrombophlebitis (HP:0004418)1.99390263
134Abnormality of chloride homeostasis (HP:0011422)1.98974599
135Decreased central vision (HP:0007663)1.98686500
136Stomach cancer (HP:0012126)1.98378682
137Delayed CNS myelination (HP:0002188)1.98146907
138Male pseudohermaphroditism (HP:0000037)1.97935422
139Postaxial foot polydactyly (HP:0001830)1.97268914
140Hypothermia (HP:0002045)1.97175484
141Abnormal rod and cone electroretinograms (HP:0008323)1.96748003
142Ileus (HP:0002595)1.96373758
143Symptomatic seizures (HP:0011145)1.96136491
144Sclerocornea (HP:0000647)1.95881380
145Nephritis (HP:0000123)1.95665171
146Abnormality of the vitamin B12 metabolism (HP:0004341)1.95622691
147Abnormality of the renal collecting system (HP:0004742)1.95230968
148Pendular nystagmus (HP:0012043)1.93586015
149Large for gestational age (HP:0001520)1.93220065
150Increased purine levels (HP:0004368)1.92652289
151Hyperuricemia (HP:0002149)1.92652289
152Dicarboxylic aciduria (HP:0003215)1.92360091
153Abnormality of dicarboxylic acid metabolism (HP:0010995)1.92360091
154Abnormality of the labia majora (HP:0012881)1.92273918
155Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91371700
156Clumsiness (HP:0002312)1.89153929
157Increased corneal curvature (HP:0100692)1.88953295
158Keratoconus (HP:0000563)1.88953295
159Poikilocytosis (HP:0004447)1.87098354
160Reduced antithrombin III activity (HP:0001976)1.86870172
161Abnormal biliary tract morphology (HP:0012440)1.86089888
162Increased mean platelet volume (HP:0011877)1.85857778
163Hemorrhage of the eye (HP:0011885)1.85269788
164Elevated alkaline phosphatase (HP:0003155)1.84053410
165Abnormality of transition element cation homeostasis (HP:0011030)1.83664223
166Skin nodule (HP:0200036)1.83426705
167Genital tract atresia (HP:0001827)1.82871353
168Abnormality of alkaline phosphatase activity (HP:0004379)1.82822299
169Rickets (HP:0002748)1.81664852
170Generalized hypopigmentation of hair (HP:0011358)1.81524537
171Glycosuria (HP:0003076)1.81148582
172Abnormality of urine glucose concentration (HP:0011016)1.81148582
173Abnormal platelet function (HP:0011869)1.80812106
174Impaired platelet aggregation (HP:0003540)1.80812106
175Nephrogenic diabetes insipidus (HP:0009806)1.80669369
176Broad-based gait (HP:0002136)1.80142209
177Pigmentary retinal degeneration (HP:0001146)1.78643898
178Mitral stenosis (HP:0001718)1.78137078
179Confusion (HP:0001289)1.78129194
180Vaginal atresia (HP:0000148)1.77410007
181Periodontitis (HP:0000704)1.76422631
182Hypochromic microcytic anemia (HP:0004840)1.76247682
183Aplasia/Hypoplasia of the spleen (HP:0010451)1.75272219
184Duplicated collecting system (HP:0000081)1.72166661
185Asplenia (HP:0001746)1.68399407
186Hyperkalemia (HP:0002153)1.64539467
187Patellar aplasia (HP:0006443)1.63714818
188Abnormality of potassium homeostasis (HP:0011042)1.63066844
189Short hallux (HP:0010109)1.61942544
190Bronchitis (HP:0012387)1.61446544
191Hypokalemia (HP:0002900)1.61228372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.29396896
2FRK5.15627347
3BMPR1B3.43327389
4SIK12.99244849
5MST1R2.90781544
6ERN12.68664581
7LATS12.67042728
8TAOK32.65481049
9ADRBK22.51676507
10BCKDK2.39899230
11INSRR2.30951927
12FGFR42.17989062
13MST42.17544208
14MAP3K142.14149209
15NUAK11.87608068
16TLK11.87586240
17TYK21.83426690
18MAP4K21.81844625
19PINK11.77243018
20FLT31.64942382
21MAPK131.62730284
22PTK61.62452075
23FGFR31.59170876
24CASK1.57796282
25MAP3K41.54704000
26CAMK1D1.54562162
27NEK91.50718457
28EPHA21.45701685
29JAK11.43358506
30JAK31.38438475
31RIPK11.37566124
32STK31.34468139
33LMTK21.33530762
34TGFBR21.32422719
35TNIK1.31364043
36IRAK31.30088804
37STK101.29887259
38MAPK111.29679207
39ERBB41.29280460
40TGFBR11.24197706
41PKN21.23432277
42CDK61.22583033
43TBK11.22198306
44ERBB31.22088893
45SCYL21.20085766
46PRKAA21.19974254
47MAP3K31.16018629
48ADRBK11.14026640
49EEF2K1.13221851
50DAPK21.11453097
51MKNK21.04190710
52MAP3K70.99520206
53PIK3CA0.99214587
54JAK20.95934582
55PIK3CG0.92971076
56PRKG20.92659078
57MET0.92501251
58IKBKE0.91245838
59MAP3K20.89966434
60MAPKAPK30.89571458
61STK240.89275856
62TEC0.88429179
63MAP2K30.87803523
64AKT30.87134789
65MAP2K70.85077767
66FGFR20.84771853
67ERBB20.84295423
68NLK0.83261864
69MAP2K20.83021789
70CHUK0.82255908
71MAP4K10.81128953
72EPHA30.81013684
73BCR0.80663370
74PRKCE0.80449563
75CSF1R0.80323885
76CSK0.77648931
77TRPM70.77321055
78STK390.76959053
79ITK0.76903339
80IRAK40.76667030
81CAMKK20.74163559
82ZAK0.73196746
83MAP3K100.72041062
84NEK20.70045389
85CDK90.69768950
86MAP2K60.68427735
87PAK30.67249657
88STK38L0.66409759
89PDK20.66379205
90WNK10.66243143
91PBK0.66083095
92SGK30.65924006
93OXSR10.65205704
94RPS6KA40.64254969
95PNCK0.63659689
96IKBKB0.63060330
97GRK60.63031988
98MAP3K130.62518606
99KIT0.62276604
100LRRK20.62081243
101MUSK0.61361211
102PRKAA10.60903492
103TRIB30.60653332
104TXK0.60047009
105CAMK1G0.59038972
106KDR0.58406816
107WNK30.56990729
108ZAP700.56256785
109TRIM280.55724459
110BTK0.55323823
111GRK10.55236529
112EIF2AK30.53362631
113MAPK150.52109429
114GSK3A0.52001296
115MELK0.51320597
116PIM10.50877383
117CDK80.50738902
118YES10.49519589
119SGK20.49343063
120PRKCQ0.46863197
121BLK0.46115385
122IGF1R0.45425979
123SIK30.44246919
124FER0.44071575
125MATK0.43666161
126RPS6KA50.43005051
127EIF2AK20.42904141
128WNK40.42072850
129MAP2K10.40212013
130MAP3K80.40121611
131BRSK20.38894019
132ABL10.38561650
133IRAK10.37809338
134PTK2B0.37787968
135CAMK2A0.37199143
136CSNK1A10.35994110
137TIE10.34682773
138PRKACA0.34378694
139PRKCA0.33950541
140PRKCI0.32874951
141PRKCG0.32323926
142MKNK10.31676896
143WEE10.30774078
144SGK2230.30658128
145SGK4940.30658128
146STK110.29931606
147SGK10.28271226
148RPS6KA60.27901806
149CSNK1A1L0.26225261
150NEK60.26129623
151STK380.24314510
152PRKCZ0.24070424
153CSNK1D0.23786332
154PHKG10.23277118
155PHKG20.23277118
156MAPKAPK50.22154198
157CSNK1G10.21219674

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.58126055
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.47298347
3Nitrogen metabolism_Homo sapiens_hsa009103.02253541
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.80158767
5Tryptophan metabolism_Homo sapiens_hsa003802.54957946
6Sulfur metabolism_Homo sapiens_hsa009202.50422100
7Arginine biosynthesis_Homo sapiens_hsa002202.45803892
8Fatty acid degradation_Homo sapiens_hsa000712.37788310
9Caffeine metabolism_Homo sapiens_hsa002322.31790131
10Complement and coagulation cascades_Homo sapiens_hsa046102.14820349
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11900015
12Histidine metabolism_Homo sapiens_hsa003402.06555820
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05965300
14Peroxisome_Homo sapiens_hsa041461.96065605
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90585252
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.89581213
17Selenocompound metabolism_Homo sapiens_hsa004501.88267293
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.84841408
19Chemical carcinogenesis_Homo sapiens_hsa052041.84227523
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83485001
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82205564
22Starch and sucrose metabolism_Homo sapiens_hsa005001.75456192
23PPAR signaling pathway_Homo sapiens_hsa033201.74274510
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.73303180
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.71014742
26Propanoate metabolism_Homo sapiens_hsa006401.68875728
27Phototransduction_Homo sapiens_hsa047441.68858684
28Vitamin digestion and absorption_Homo sapiens_hsa049771.67293600
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.67019322
30beta-Alanine metabolism_Homo sapiens_hsa004101.63280560
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62354862
32Bile secretion_Homo sapiens_hsa049761.61513006
33Butanoate metabolism_Homo sapiens_hsa006501.59310720
34Fat digestion and absorption_Homo sapiens_hsa049751.58319133
35Staphylococcus aureus infection_Homo sapiens_hsa051501.54930788
36Ether lipid metabolism_Homo sapiens_hsa005651.52652910
37ABC transporters_Homo sapiens_hsa020101.50494161
38Retinol metabolism_Homo sapiens_hsa008301.50104241
39Fatty acid metabolism_Homo sapiens_hsa012121.48166445
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.43513126
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41916960
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40777928
43Folate biosynthesis_Homo sapiens_hsa007901.38600391
44Arachidonic acid metabolism_Homo sapiens_hsa005901.22972653
45Taste transduction_Homo sapiens_hsa047421.22581319
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18556956
47Lysine degradation_Homo sapiens_hsa003101.14693794
48Nicotine addiction_Homo sapiens_hsa050331.14628341
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11683231
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09094115
51Phenylalanine metabolism_Homo sapiens_hsa003601.04949491
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04296396
53Renin-angiotensin system_Homo sapiens_hsa046141.03190728
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01023168
55Glutathione metabolism_Homo sapiens_hsa004800.92553987
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91367811
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88145238
58Pyruvate metabolism_Homo sapiens_hsa006200.87253267
59Tyrosine metabolism_Homo sapiens_hsa003500.86141425
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.83763908
61Arginine and proline metabolism_Homo sapiens_hsa003300.83482767
62Mineral absorption_Homo sapiens_hsa049780.83312260
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.81600939
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80788434
65Olfactory transduction_Homo sapiens_hsa047400.80522185
66Carbon metabolism_Homo sapiens_hsa012000.79820218
67Pentose phosphate pathway_Homo sapiens_hsa000300.79523727
68Homologous recombination_Homo sapiens_hsa034400.79031919
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78919058
70Glycerolipid metabolism_Homo sapiens_hsa005610.77761905
71Ovarian steroidogenesis_Homo sapiens_hsa049130.76868584
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75197286
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74157593
74One carbon pool by folate_Homo sapiens_hsa006700.73032017
75Biosynthesis of amino acids_Homo sapiens_hsa012300.69980893
76Salivary secretion_Homo sapiens_hsa049700.67381859
77Fanconi anemia pathway_Homo sapiens_hsa034600.66364507
78Galactose metabolism_Homo sapiens_hsa000520.65139191
79Steroid biosynthesis_Homo sapiens_hsa001000.64832461
80Circadian rhythm_Homo sapiens_hsa047100.64759269
81Fatty acid biosynthesis_Homo sapiens_hsa000610.63527771
82Serotonergic synapse_Homo sapiens_hsa047260.63247258
83Asthma_Homo sapiens_hsa053100.62853430
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62471337
85Dorso-ventral axis formation_Homo sapiens_hsa043200.59570064
86Sulfur relay system_Homo sapiens_hsa041220.58296590
87Fructose and mannose metabolism_Homo sapiens_hsa000510.57094635
88Sphingolipid metabolism_Homo sapiens_hsa006000.56716390
89Pancreatic secretion_Homo sapiens_hsa049720.56490101
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52998427
91Insulin secretion_Homo sapiens_hsa049110.51590916
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50896469
93Insulin resistance_Homo sapiens_hsa049310.49608173
94Fatty acid elongation_Homo sapiens_hsa000620.48349172
95Renin secretion_Homo sapiens_hsa049240.45281693
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44215293
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.43822449
98Morphine addiction_Homo sapiens_hsa050320.43346629
99Protein digestion and absorption_Homo sapiens_hsa049740.42558073
100Glutamatergic synapse_Homo sapiens_hsa047240.41642367
101Calcium signaling pathway_Homo sapiens_hsa040200.41074081
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39945475
103TGF-beta signaling pathway_Homo sapiens_hsa043500.38824887
104Legionellosis_Homo sapiens_hsa051340.38473133
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.38469363
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37372913
107Basal transcription factors_Homo sapiens_hsa030220.36933000
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36221034
109Graft-versus-host disease_Homo sapiens_hsa053320.35820172
110Other glycan degradation_Homo sapiens_hsa005110.35654207
111Vitamin B6 metabolism_Homo sapiens_hsa007500.34376566
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34044518
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.33882944
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33691222
115Long-term depression_Homo sapiens_hsa047300.33114322
116Metabolic pathways_Homo sapiens_hsa011000.32311931
117Hepatitis C_Homo sapiens_hsa051600.32100799
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.32066723
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28534879
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27209128
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27054478
122Circadian entrainment_Homo sapiens_hsa047130.26711721
123Small cell lung cancer_Homo sapiens_hsa052220.23760278
124Regulation of autophagy_Homo sapiens_hsa041400.23555419
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22612916
126Leishmaniasis_Homo sapiens_hsa051400.22013777
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21597500
128Autoimmune thyroid disease_Homo sapiens_hsa053200.20442174
129Hedgehog signaling pathway_Homo sapiens_hsa043400.20427175
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.19921613
131Protein export_Homo sapiens_hsa030600.18677179
132Toxoplasmosis_Homo sapiens_hsa051450.18309229
133Influenza A_Homo sapiens_hsa051640.18264978
134TNF signaling pathway_Homo sapiens_hsa046680.18113646
135N-Glycan biosynthesis_Homo sapiens_hsa005100.17099635
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16991460
137Pertussis_Homo sapiens_hsa051330.16955672
138Type I diabetes mellitus_Homo sapiens_hsa049400.16550498
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16132071
140Hematopoietic cell lineage_Homo sapiens_hsa046400.10926965
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.10890507
142Linoleic acid metabolism_Homo sapiens_hsa005910.10085591

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