SLC35A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.17282730
2axon ensheathment in central nervous system (GO:0032291)8.17282730
3fatty acid elongation (GO:0030497)5.34261870
4myelination (GO:0042552)4.67822301
5ensheathment of neurons (GO:0007272)4.64025164
6axon ensheathment (GO:0008366)4.64025164
7regulation of meiosis I (GO:0060631)4.48373993
8DNA double-strand break processing (GO:0000729)4.29438338
9long-chain fatty acid biosynthetic process (GO:0042759)4.23210220
10signal peptide processing (GO:0006465)3.96909028
11negative regulation of neurotransmitter secretion (GO:0046929)3.92522083
12negative regulation of neurotransmitter transport (GO:0051589)3.84930324
13L-amino acid import (GO:0043092)3.81852832
14presynaptic membrane assembly (GO:0097105)3.76955709
15presynaptic membrane organization (GO:0097090)3.75183842
16gonadal mesoderm development (GO:0007506)3.67071507
17myelin maintenance (GO:0043217)3.59304934
18protein localization to cilium (GO:0061512)3.57454654
19oligodendrocyte differentiation (GO:0048709)3.46370157
20positive regulation of mitochondrial fission (GO:0090141)3.40704665
21pyrimidine nucleobase catabolic process (GO:0006208)3.39206696
22photoreceptor cell differentiation (GO:0046530)3.39194239
23eye photoreceptor cell differentiation (GO:0001754)3.39194239
24detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38357131
25glycerophospholipid catabolic process (GO:0046475)3.34549303
26piRNA metabolic process (GO:0034587)3.33555565
27response to methylmercury (GO:0051597)3.30513936
28acrosome assembly (GO:0001675)3.29633493
29positive regulation of meiosis (GO:0045836)3.29416195
30regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.21426831
31glycosphingolipid biosynthetic process (GO:0006688)3.20982401
32cullin deneddylation (GO:0010388)3.20765238
33establishment of protein localization to Golgi (GO:0072600)3.18485267
34neural tube formation (GO:0001841)3.17037985
35response to lipoprotein particle (GO:0055094)3.16850581
36single strand break repair (GO:0000012)3.13316575
37asymmetric protein localization (GO:0008105)3.10718104
38synapsis (GO:0007129)3.08589695
39photoreceptor cell maintenance (GO:0045494)3.08033547
40amino acid import (GO:0043090)3.07908884
41retinal cone cell development (GO:0046549)3.07838672
42cholesterol biosynthetic process (GO:0006695)3.07457454
43righting reflex (GO:0060013)3.05117915
44behavioral response to ethanol (GO:0048149)3.04786487
45apical protein localization (GO:0045176)3.02798781
46positive regulation of meiotic cell cycle (GO:0051446)2.98312437
47neuron cell-cell adhesion (GO:0007158)2.98052714
48protein K11-linked deubiquitination (GO:0035871)2.96650451
49intraciliary transport (GO:0042073)2.96624365
50negative regulation of DNA recombination (GO:0045910)2.95474643
51response to redox state (GO:0051775)2.94738345
52negative regulation of protein localization to cell surface (GO:2000009)2.92611733
53nucleobase catabolic process (GO:0046113)2.92544012
54protein targeting to Golgi (GO:0000042)2.92462880
55regulation of collateral sprouting (GO:0048670)2.91902332
56myelination in peripheral nervous system (GO:0022011)2.91483795
57peripheral nervous system axon ensheathment (GO:0032292)2.91483795
58negative regulation of meiosis (GO:0045835)2.90810376
59import into cell (GO:0098657)2.87628958
60Golgi to endosome transport (GO:0006895)2.86903636
61positive regulation of oligodendrocyte differentiation (GO:0048714)2.83682026
62astrocyte development (GO:0014002)2.83579281
63resolution of meiotic recombination intermediates (GO:0000712)2.81000991
64mannosylation (GO:0097502)2.80972188
65long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.79751078
66preassembly of GPI anchor in ER membrane (GO:0016254)2.78834114
67C4-dicarboxylate transport (GO:0015740)2.77084089
68inositol phosphate catabolic process (GO:0071545)2.76130013
69positive regulation of mitotic sister chromatid separation (GO:1901970)2.76003471
70positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76003471
71positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76003471
72adhesion of symbiont to host cell (GO:0044650)2.74225083
73virion attachment to host cell (GO:0019062)2.74225083
74creatine metabolic process (GO:0006600)2.73211669
75protein deneddylation (GO:0000338)2.72084759
76long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.70954222
77negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.70843525
78neuronal action potential propagation (GO:0019227)2.70659320
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70431893
80anterograde synaptic vesicle transport (GO:0048490)2.70229314
81substantia nigra development (GO:0021762)2.69986768
82sterol biosynthetic process (GO:0016126)2.69751071
83germ cell migration (GO:0008354)2.69600516
84protein palmitoylation (GO:0018345)2.68432335
85cerebral cortex radially oriented cell migration (GO:0021799)2.68233437
86male meiosis (GO:0007140)2.68104703
87establishment of mitochondrion localization (GO:0051654)2.67784181
88adult walking behavior (GO:0007628)2.67234957
89cilium morphogenesis (GO:0060271)2.66700839
90peptidyl-tyrosine autophosphorylation (GO:0038083)2.66034234
91ribonucleoprotein complex disassembly (GO:0032988)2.65913407
92phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64681752
93inositol phosphate dephosphorylation (GO:0046855)2.64681752
94neuron remodeling (GO:0016322)2.62125433
95cilium organization (GO:0044782)2.58229020
96cilium assembly (GO:0042384)2.58089125
97retrograde transport, vesicle recycling within Golgi (GO:0000301)2.56445558
98prenylation (GO:0097354)2.55988495
99protein prenylation (GO:0018342)2.55988495
100nonmotile primary cilium assembly (GO:0035058)2.55429742
101kynurenine metabolic process (GO:0070189)2.54366652
102negative regulation of DNA-dependent DNA replication (GO:2000104)2.51253349
103regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.51007506
104membrane assembly (GO:0071709)2.50010186
105microtubule anchoring (GO:0034453)2.49496226
106acrosome reaction (GO:0007340)2.49090600
107olfactory bulb development (GO:0021772)2.48914914
108leukocyte migration involved in inflammatory response (GO:0002523)2.48875048
109amyloid precursor protein metabolic process (GO:0042982)2.48329023
110cellular response to sterol (GO:0036315)2.48232063
111S-adenosylmethionine metabolic process (GO:0046500)2.48211026
112regulation of timing of cell differentiation (GO:0048505)2.47848196
113regulation of acyl-CoA biosynthetic process (GO:0050812)2.47712674
114very long-chain fatty acid metabolic process (GO:0000038)2.47430512
115regulation of protein glycosylation (GO:0060049)2.46150246
116magnesium ion transport (GO:0015693)2.45744265
117regulation of amyloid precursor protein catabolic process (GO:1902991)2.44871359
118centriole replication (GO:0007099)2.44212393
119neurotransmitter uptake (GO:0001504)2.44191830
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.44176652
121protein targeting to vacuole (GO:0006623)2.43657949
122protein targeting to lysosome (GO:0006622)2.43657949
123establishment of protein localization to vacuole (GO:0072666)2.43657949
124brain morphogenesis (GO:0048854)2.43551988
125regulation of glucokinase activity (GO:0033131)2.42371818
126regulation of hexokinase activity (GO:1903299)2.42371818
127isoprenoid biosynthetic process (GO:0008299)2.42263948
128positive regulation of action potential (GO:0045760)2.42100325
129postreplication repair (GO:0006301)2.41633191
130reflex (GO:0060004)2.41383193
131synaptic vesicle exocytosis (GO:0016079)2.41256448
132regulation of development, heterochronic (GO:0040034)2.41069215
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.41041316
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.40465668
135negative regulation of JUN kinase activity (GO:0043508)2.39490071
136positive regulation of growth hormone secretion (GO:0060124)2.38825533
137regulation of beta-amyloid formation (GO:1902003)2.38323748
138transmission of nerve impulse (GO:0019226)2.38068296
139intra-Golgi vesicle-mediated transport (GO:0006891)2.37960877
140fatty-acyl-CoA biosynthetic process (GO:0046949)2.37777512
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37131861
142response to pheromone (GO:0019236)2.37081125
143chromatin remodeling at centromere (GO:0031055)2.36980905
144glycosylceramide metabolic process (GO:0006677)2.36742305
145DNA integration (GO:0015074)2.35698725
146fatty-acyl-CoA metabolic process (GO:0035337)2.35141925
147detection of light stimulus involved in visual perception (GO:0050908)2.34973004
148detection of light stimulus involved in sensory perception (GO:0050962)2.34973004
149platelet dense granule organization (GO:0060155)2.34840385
150regulation of lipoprotein metabolic process (GO:0050746)2.34831173
151regulation of mitochondrial fission (GO:0090140)2.34687394
152replication fork processing (GO:0031297)2.33487801
153dopamine transport (GO:0015872)2.33249449
154axon development (GO:0061564)2.33244021
155tryptophan catabolic process (GO:0006569)2.33038682
156indole-containing compound catabolic process (GO:0042436)2.33038682
157indolalkylamine catabolic process (GO:0046218)2.33038682
158axonal fasciculation (GO:0007413)2.32302846
159CENP-A containing nucleosome assembly (GO:0034080)2.32047734
160peripheral nervous system development (GO:0007422)2.31157063
161GPI anchor metabolic process (GO:0006505)2.28212237
162gamma-aminobutyric acid signaling pathway (GO:0007214)2.28059488
163gamma-aminobutyric acid transport (GO:0015812)2.27041626
164positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.26846703
165limb bud formation (GO:0060174)2.25970961
166detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.25559161
167detection of temperature stimulus involved in sensory perception (GO:0050961)2.25559161
168negative regulation of axonogenesis (GO:0050771)2.24477379
169synaptic vesicle maturation (GO:0016188)2.23972498
170regulation of synaptic vesicle exocytosis (GO:2000300)2.23589517
171GPI anchor biosynthetic process (GO:0006506)2.21760979
172cerebellar granule cell differentiation (GO:0021707)2.20412121
173glycine transport (GO:0015816)2.17965986
174nerve growth factor signaling pathway (GO:0038180)2.17253722
175activated T cell proliferation (GO:0050798)2.13725479
176regulation of voltage-gated calcium channel activity (GO:1901385)2.13497850
177negative regulation of inclusion body assembly (GO:0090084)2.12856182
178negative regulation of acute inflammatory response (GO:0002674)2.11404333
179glutamate secretion (GO:0014047)2.09969693
180dopamine biosynthetic process (GO:0042416)2.09315519
181membrane raft organization (GO:0031579)2.08532994
182regulation of vacuole organization (GO:0044088)2.07970288
183glutathione biosynthetic process (GO:0006750)2.07473839
184regulation of catecholamine metabolic process (GO:0042069)2.07042463
185regulation of dopamine metabolic process (GO:0042053)2.07042463
186peptidyl-cysteine modification (GO:0018198)2.06453619
187negative regulation of synaptic transmission (GO:0050805)2.04355178
188negative regulation of exocytosis (GO:0045920)2.03397065
189acidic amino acid transport (GO:0015800)2.02234093
190cyclic nucleotide catabolic process (GO:0009214)2.01282755
191glial cell differentiation (GO:0010001)1.99294669
192positive regulation of cellular amine metabolic process (GO:0033240)1.99278709
193positive regulation of glial cell differentiation (GO:0045687)1.98770940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.31229125
2ZNF274_21170338_ChIP-Seq_K562_Hela2.53310266
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.52228449
4TAF15_26573619_Chip-Seq_HEK293_Human2.30205293
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27895217
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27001037
7EWS_26573619_Chip-Seq_HEK293_Human2.26403914
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14663382
9EZH2_22144423_ChIP-Seq_EOC_Human2.13560208
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06136870
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06034615
12JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98953716
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96146296
14AR_21572438_ChIP-Seq_LNCaP_Human1.93578719
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92962830
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91629879
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91233238
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90571051
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89165878
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84674875
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.82541998
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.82541998
23* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80909324
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77980451
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.76699605
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75267336
27VDR_22108803_ChIP-Seq_LS180_Human1.74300194
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.70628838
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66937086
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.64957348
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64793029
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.64091119
33P300_19829295_ChIP-Seq_ESCs_Human1.63741554
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63494979
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.63036690
36CBP_20019798_ChIP-Seq_JUKART_Human1.62048584
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62048584
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56077848
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55260343
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52499719
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51577472
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.48675648
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.48650988
44BCAT_22108803_ChIP-Seq_LS180_Human1.48517550
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48122282
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.45468169
47ELK1_19687146_ChIP-ChIP_HELA_Human1.43722636
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.42336830
49ER_23166858_ChIP-Seq_MCF-7_Human1.41459554
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.41346365
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40821505
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.40301971
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.38558418
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35946424
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35926204
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35531981
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35531981
58TCF4_22108803_ChIP-Seq_LS180_Human1.35252345
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34049624
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32147638
61DROSHA_22980978_ChIP-Seq_HELA_Human1.29306789
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28787718
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.28683955
64IGF1R_20145208_ChIP-Seq_DFB_Human1.28311939
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27494182
66CDX2_22108803_ChIP-Seq_LS180_Human1.26763169
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25817879
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24808767
69REST_21632747_ChIP-Seq_MESCs_Mouse1.23377424
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23095807
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22470543
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20627095
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.20432321
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20124369
75FUS_26573619_Chip-Seq_HEK293_Human1.19901174
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.19733989
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19323344
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19100560
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19030289
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18854630
81IRF1_19129219_ChIP-ChIP_H3396_Human1.18339029
82* STAT3_23295773_ChIP-Seq_U87_Human1.17631455
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.16860153
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16788415
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15655763
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.15064950
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14827103
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14559466
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13945092
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13471883
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12783698
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.12075411
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11086232
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11014593
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11014593
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10938446
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.10930762
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10838407
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09501660
100JUN_21703547_ChIP-Seq_K562_Human1.08721518
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08685665
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08663298
103AR_25329375_ChIP-Seq_VCAP_Human1.08120964
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.07795425
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07691339
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.07614281
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07543448
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07186923
109TAL1_26923725_Chip-Seq_HPCs_Mouse1.06801327
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06602213
111RNF2_27304074_Chip-Seq_NSC_Mouse1.06457853
112TP53_18474530_ChIP-ChIP_U2OS_Human1.06192219
113AHR_22903824_ChIP-Seq_MCF-7_Human1.05826114
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05418571
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.05188553
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.04832867
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04566491
118* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04418698
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04294060
120TP53_22573176_ChIP-Seq_HFKS_Human1.03978956
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02681556
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02611375
123KDM2B_26808549_Chip-Seq_REH_Human1.01033422
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01023267
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00786701
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00780256
127P53_22387025_ChIP-Seq_ESCs_Mouse1.00759464
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00238496
129TCF4_23295773_ChIP-Seq_U87_Human1.00183238
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.00027861
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99889243
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99591764
133P300_18555785_Chip-Seq_ESCs_Mouse0.99094405
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98000805
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.95549288
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95451620
137RUNX2_22187159_ChIP-Seq_PCA_Human0.95368431
138STAT3_18555785_Chip-Seq_ESCs_Mouse0.95083497
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94396358
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.92498034
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92280096
142EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92005336
143NANOG_19829295_ChIP-Seq_ESCs_Human0.91518356
144SOX2_19829295_ChIP-Seq_ESCs_Human0.91518356

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.10635014
2MP0003880_abnormal_central_pattern3.61874799
3MP0000569_abnormal_digit_pigmentation3.52059339
4MP0008877_abnormal_DNA_methylation3.33150181
5MP0004270_analgesia3.18777556
6MP0003690_abnormal_glial_cell3.11123449
7MP0003136_yellow_coat_color3.08765935
8MP0003950_abnormal_plasma_membrane3.01234758
9MP0002102_abnormal_ear_morphology2.81462759
10MP0008057_abnormal_DNA_replication2.62549603
11MP0004859_abnormal_synaptic_plasticity2.35028024
12MP0001486_abnormal_startle_reflex2.33374031
13MP0003329_amyloid_beta_deposits2.28578860
14MP0002064_seizures2.24948081
15MP0002272_abnormal_nervous_system2.24910698
16MP0002734_abnormal_mechanical_nocicepti2.14306122
17MP0003634_abnormal_glial_cell2.13282984
18MP0004885_abnormal_endolymph2.12680849
19MP0001905_abnormal_dopamine_level2.07782527
20MP0005171_absent_coat_pigmentation2.07537377
21MP0009780_abnormal_chondrocyte_physiolo2.02970036
22MP0009046_muscle_twitch2.01358639
23MP0003635_abnormal_synaptic_transmissio1.99102472
24MP0009745_abnormal_behavioral_response1.98368703
25MP0004742_abnormal_vestibular_system1.93776956
26MP0005187_abnormal_penis_morphology1.86675696
27MP0000778_abnormal_nervous_system1.78828060
28MP0001968_abnormal_touch/_nociception1.77593300
29MP0001529_abnormal_vocalization1.74843998
30MP0004142_abnormal_muscle_tone1.73372877
31MP0005646_abnormal_pituitary_gland1.71666820
32MP0005423_abnormal_somatic_nervous1.68129930
33MP0002735_abnormal_chemical_nociception1.67012024
34MP0001986_abnormal_taste_sensitivity1.65353109
35MP0003633_abnormal_nervous_system1.64928858
36MP0005174_abnormal_tail_pigmentation1.64709212
37MP0002736_abnormal_nociception_after1.63580719
38MP0001188_hyperpigmentation1.63277785
39MP0000604_amyloidosis1.61169479
40MP0002063_abnormal_learning/memory/cond1.59332226
41MP0002572_abnormal_emotion/affect_behav1.58626804
42MP0001970_abnormal_pain_threshold1.58176275
43MP0002229_neurodegeneration1.56404020
44MP0003718_maternal_effect1.54522159
45MP0003787_abnormal_imprinting1.53447517
46MP0005410_abnormal_fertilization1.52356359
47MP0006054_spinal_hemorrhage1.51546231
48MP0004043_abnormal_pH_regulation1.46709056
49MP0000427_abnormal_hair_cycle1.46140436
50MP0005551_abnormal_eye_electrophysiolog1.43026909
51MP0001485_abnormal_pinna_reflex1.42807636
52MP0003631_nervous_system_phenotype1.42099748
53MP0002837_dystrophic_cardiac_calcinosis1.41848357
54MP0002067_abnormal_sensory_capabilities1.40653927
55MP0003252_abnormal_bile_duct1.39755517
56MP0004215_abnormal_myocardial_fiber1.37501301
57MP0004381_abnormal_hair_follicle1.36757065
58MP0001440_abnormal_grooming_behavior1.35530857
59MP0008260_abnormal_autophagy1.35278286
60MP0002638_abnormal_pupillary_reflex1.35013330
61MP0002733_abnormal_thermal_nociception1.33060362
62MP0008058_abnormal_DNA_repair1.30619752
63MP0005058_abnormal_lysosome_morphology1.30502468
64MP0005409_darkened_coat_color1.27461543
65MP0008789_abnormal_olfactory_epithelium1.27366147
66MP0008569_lethality_at_weaning1.26621060
67MP0000015_abnormal_ear_pigmentation1.23693441
68MP0003632_abnormal_nervous_system1.23203420
69MP0002938_white_spotting1.22696590
70MP0001501_abnormal_sleep_pattern1.17737094
71MP0001502_abnormal_circadian_rhythm1.17455983
72MP0000955_abnormal_spinal_cord1.16561967
73MP0002882_abnormal_neuron_morphology1.16438190
74MP0002928_abnormal_bile_duct1.16402009
75MP0001963_abnormal_hearing_physiology1.15747337
76MP0004924_abnormal_behavior1.13681984
77MP0005386_behavior/neurological_phenoty1.13681984
78MP0010368_abnormal_lymphatic_system1.11964429
79MP0000516_abnormal_urinary_system1.10928089
80MP0005367_renal/urinary_system_phenotyp1.10928089
81MP0002909_abnormal_adrenal_gland1.10533402
82MP0010386_abnormal_urinary_bladder1.09907300
83MP0002090_abnormal_vision1.09036044
84MP0002751_abnormal_autonomic_nervous1.08181474
85MP0002095_abnormal_skin_pigmentation1.07229493
86MP0001929_abnormal_gametogenesis1.07197961
87MP0009697_abnormal_copulation1.06824981
88MP0005084_abnormal_gallbladder_morpholo1.04726764
89MP0003195_calcinosis1.04174772
90MP0002160_abnormal_reproductive_system1.03364684
91MP0003183_abnormal_peptide_metabolism1.03234520
92MP0003121_genomic_imprinting1.03112412
93MP0003122_maternal_imprinting1.02911845
94MP0002066_abnormal_motor_capabilities/c1.02691733
95MP0005085_abnormal_gallbladder_physiolo1.01148392
96MP0010678_abnormal_skin_adnexa1.01066594
97MP0003698_abnormal_male_reproductive0.99797844
98MP0001293_anophthalmia0.99655655
99MP0001984_abnormal_olfaction0.99652210
100MP0003075_altered_response_to0.98899660
101MP0005499_abnormal_olfactory_system0.98814853
102MP0005394_taste/olfaction_phenotype0.98814853
103MP0005670_abnormal_white_adipose0.97929031
104MP0003567_abnormal_fetal_cardiomyocyte0.96550105
105MP0002233_abnormal_nose_morphology0.96410796
106MP0004134_abnormal_chest_morphology0.95443970
107MP0003890_abnormal_embryonic-extraembry0.95438749
108MP0006276_abnormal_autonomic_nervous0.93093308
109MP0002557_abnormal_social/conspecific_i0.92527073
110MP0005379_endocrine/exocrine_gland_phen0.92450542
111MP0005645_abnormal_hypothalamus_physiol0.91654908
112MP0000653_abnormal_sex_gland0.91361673
113MP0001346_abnormal_lacrimal_gland0.90862766
114MP0002234_abnormal_pharynx_morphology0.90475689
115MP0005623_abnormal_meninges_morphology0.90192759
116MP0004133_heterotaxia0.89500040
117MP0005408_hypopigmentation0.88310269
118MP0002295_abnormal_pulmonary_circulatio0.88083287
119MP0002210_abnormal_sex_determination0.86769971
120MP0002752_abnormal_somatic_nervous0.85943171
121MP0004811_abnormal_neuron_physiology0.85548317
122MP0005391_vision/eye_phenotype0.84691070
123MP0000383_abnormal_hair_follicle0.83743096
124MP0001145_abnormal_male_reproductive0.83433449
125MP0006082_CNS_inflammation0.82904204
126MP0003191_abnormal_cellular_cholesterol0.82833091
127MP0005451_abnormal_body_composition0.82257468
128MP0001299_abnormal_eye_distance/0.81419495
129MP0005253_abnormal_eye_physiology0.81132116
130MP0003119_abnormal_digestive_system0.81033489
131MP0002184_abnormal_innervation0.79859824
132MP0001177_atelectasis0.79586513
133MP0009840_abnormal_foam_cell0.78523131
134MP0000647_abnormal_sebaceous_gland0.77846460
135MP0000462_abnormal_digestive_system0.76498692
136MP0000026_abnormal_inner_ear0.76379443
137MP0000372_irregular_coat_pigmentation0.75053696
138MP0005195_abnormal_posterior_eye0.75051159
139MP0000639_abnormal_adrenal_gland0.75014008
140MP0001851_eye_inflammation0.73822319
141MP0004858_abnormal_nervous_system0.73219493
142MP0003724_increased_susceptibility_to0.72073044
143MP0006072_abnormal_retinal_apoptosis0.71534178
144MP0009384_cardiac_valve_regurgitation0.70158644
145MP0004147_increased_porphyrin_level0.68739992
146MP0005167_abnormal_blood-brain_barrier0.68338322
147MP0002822_catalepsy0.66847271
148MP0003879_abnormal_hair_cell0.66606163
149MP0002009_preneoplasia0.65904976

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.08375888
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.72269576
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.72269576
4Cerebral inclusion bodies (HP:0100314)4.26415394
5Parakeratosis (HP:0001036)3.96598292
6Abnormality of the corticospinal tract (HP:0002492)3.63265770
7Supranuclear gaze palsy (HP:0000605)3.53799141
8Sensory axonal neuropathy (HP:0003390)3.52605047
9Peripheral hypomyelination (HP:0007182)3.44690166
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.40026295
11Onion bulb formation (HP:0003383)3.19134632
12Tubulointerstitial nephritis (HP:0001970)3.12595046
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.08325319
14Abnormal respiratory motile cilium physiology (HP:0012261)3.01896652
15Abnormal ciliary motility (HP:0012262)3.01587459
16Pheochromocytoma (HP:0002666)2.99517681
17Molar tooth sign on MRI (HP:0002419)2.97641565
18Abnormality of midbrain morphology (HP:0002418)2.97641565
19Pancreatic fibrosis (HP:0100732)2.95584204
20Myokymia (HP:0002411)2.89491683
21Aplasia involving bones of the upper limbs (HP:0009823)2.87660100
22Aplasia of the phalanges of the hand (HP:0009802)2.87660100
23Aplasia involving bones of the extremities (HP:0009825)2.87660100
24Nephrogenic diabetes insipidus (HP:0009806)2.87230793
25Hyperglycinemia (HP:0002154)2.86827055
26Abolished electroretinogram (ERG) (HP:0000550)2.86086910
27Pancreatic cysts (HP:0001737)2.85505226
28Dysmetria (HP:0001310)2.83141803
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80287660
30Scanning speech (HP:0002168)2.78432041
31True hermaphroditism (HP:0010459)2.78331504
32Insidious onset (HP:0003587)2.77548313
33Termporal pattern (HP:0011008)2.77548313
34Nephronophthisis (HP:0000090)2.77204628
35Intention tremor (HP:0002080)2.75160024
36Abnormal auditory evoked potentials (HP:0006958)2.74517352
37Methylmalonic acidemia (HP:0002912)2.65116662
38Focal motor seizures (HP:0011153)2.63848108
39Autoamputation (HP:0001218)2.63672114
40Aplasia/Hypoplasia of the tibia (HP:0005772)2.63532718
41Clumsiness (HP:0002312)2.57299898
42Segmental peripheral demyelination/remyelination (HP:0003481)2.57075012
43Spastic gait (HP:0002064)2.56486430
44Neuroendocrine neoplasm (HP:0100634)2.54726627
45Ankle clonus (HP:0011448)2.54707929
46Absent speech (HP:0001344)2.54494820
47Progressive inability to walk (HP:0002505)2.53527020
48Retinal dysplasia (HP:0007973)2.48640384
49Abnormality of the renal medulla (HP:0100957)2.48439912
50Metabolic alkalosis (HP:0200114)2.47723357
51Abnormality of the labia minora (HP:0012880)2.46907097
52Chronic hepatic failure (HP:0100626)2.42992465
53Epileptic encephalopathy (HP:0200134)2.41665604
54Alacrima (HP:0000522)2.39806826
55Akinesia (HP:0002304)2.39129744
56Cerebral hemorrhage (HP:0001342)2.32883139
57Renal cortical cysts (HP:0000803)2.32134558
58Short tibia (HP:0005736)2.32060511
59Inability to walk (HP:0002540)2.31006208
60Megalencephaly (HP:0001355)2.29401599
61Slow saccadic eye movements (HP:0000514)2.28668390
62Thickened helices (HP:0000391)2.27558681
63Gonadotropin excess (HP:0000837)2.27328388
64Abnormal biliary tract physiology (HP:0012439)2.25341146
65Bile duct proliferation (HP:0001408)2.25341146
66Proximal tubulopathy (HP:0000114)2.25226540
67Hypokalemic alkalosis (HP:0001949)2.25012377
68Amyotrophic lateral sclerosis (HP:0007354)2.24589420
69Anteriorly placed anus (HP:0001545)2.24388143
70Increased circulating renin level (HP:0000848)2.24187130
71Absent septum pellucidum (HP:0001331)2.23840506
72Aplasia/Hypoplasia of the tongue (HP:0010295)2.22995087
73Poor coordination (HP:0002370)2.22881354
74Papillary thyroid carcinoma (HP:0002895)2.20187347
75Intestinal atresia (HP:0011100)2.18077657
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.17458255
77Absent/shortened dynein arms (HP:0200106)2.17458255
78Action tremor (HP:0002345)2.16289566
79Vaginal atresia (HP:0000148)2.14435737
80Tubulointerstitial abnormality (HP:0001969)2.14058501
81Supernumerary spleens (HP:0009799)2.13668879
82Febrile seizures (HP:0002373)2.13501393
83Colon cancer (HP:0003003)2.13264345
84Abnormality of the vitamin B12 metabolism (HP:0004341)2.12340354
85Atonic seizures (HP:0010819)2.12277379
86Hypoglycemic seizures (HP:0002173)2.12224561
87Bifid tongue (HP:0010297)2.12178252
88Abnormality of macular pigmentation (HP:0008002)2.12111425
89Axonal loss (HP:0003447)2.12027074
90Abnormality of the renal cortex (HP:0011035)2.11033873
91Hyperinsulinemic hypoglycemia (HP:0000825)2.10909620
92Lower limb muscle weakness (HP:0007340)2.10615629
93Postaxial hand polydactyly (HP:0001162)2.10488374
94Neoplasm of the adrenal cortex (HP:0100641)2.10122868
95Genital tract atresia (HP:0001827)2.09987407
96Leukodystrophy (HP:0002415)2.09909027
97Hypothermia (HP:0002045)2.09461990
98Thyroid carcinoma (HP:0002890)2.09393849
99Abnormality of vitamin B metabolism (HP:0004340)2.09211690
100Congenital ichthyosiform erythroderma (HP:0007431)2.08710061
101Hypoglycemic coma (HP:0001325)2.08172994
102Impaired vibration sensation in the lower limbs (HP:0002166)2.07946693
103Dialeptic seizures (HP:0011146)2.07928883
104Hypoplastic pelvis (HP:0008839)2.07572525
105Medulloblastoma (HP:0002885)2.07384258
106Central scotoma (HP:0000603)2.06996864
107Specific learning disability (HP:0001328)2.06746408
108Abnormality of chromosome stability (HP:0003220)2.06271436
109Rhinitis (HP:0012384)2.04997891
110Gait imbalance (HP:0002141)2.04480408
111Glioma (HP:0009733)2.04237693
112Humeroradial synostosis (HP:0003041)2.03427174
113Synostosis involving the elbow (HP:0003938)2.03427174
114Abnormality of the middle phalanges of the toes (HP:0010183)2.02283039
115Broad-based gait (HP:0002136)2.02194503
116Methylmalonic aciduria (HP:0012120)2.00821986
117Diplopia (HP:0000651)1.99962564
118Abnormality of binocular vision (HP:0011514)1.99962564
119Hemiparesis (HP:0001269)1.99954432
120Progressive cerebellar ataxia (HP:0002073)1.99465597
121Hypomagnesemia (HP:0002917)1.98691739
122Broad foot (HP:0001769)1.96546100
123Hepatosplenomegaly (HP:0001433)1.96494877
124Spastic paraparesis (HP:0002313)1.95997758
125Hyperventilation (HP:0002883)1.93941234
126Decreased lacrimation (HP:0000633)1.93403242
127Hip dysplasia (HP:0001385)1.93314704
128Medial flaring of the eyebrow (HP:0010747)1.93254432
129Neuronal loss in central nervous system (HP:0002529)1.93064066
130Poor speech (HP:0002465)1.92813856
131Paraparesis (HP:0002385)1.92626269
132Scotoma (HP:0000575)1.92046931
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.91635286
134Peripheral demyelination (HP:0011096)1.91299198
135Split foot (HP:0001839)1.89278965
136Ketoacidosis (HP:0001993)1.88114845
137Premature skin wrinkling (HP:0100678)1.87456706
138Cortical dysplasia (HP:0002539)1.86590078
139Postaxial foot polydactyly (HP:0001830)1.86356322
140Sensorimotor neuropathy (HP:0007141)1.83943840
141White forelock (HP:0002211)1.83702483
142Abnormality of the fovea (HP:0000493)1.83364792
143Abnormal protein glycosylation (HP:0012346)1.82917362
144Abnormal glycosylation (HP:0012345)1.82917362
145Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82917362
146Abnormal protein N-linked glycosylation (HP:0012347)1.82917362
147Abnormal respiratory epithelium morphology (HP:0012253)1.82257008
148Abnormal respiratory motile cilium morphology (HP:0005938)1.82257008
149Abnormality of glycine metabolism (HP:0010895)1.82211156
150Abnormality of serine family amino acid metabolism (HP:0010894)1.82211156
151Xerostomia (HP:0000217)1.81637779
152Truncal ataxia (HP:0002078)1.81321315
153Congenital primary aphakia (HP:0007707)1.80782291
154Focal seizures (HP:0007359)1.80300614
155Drooling (HP:0002307)1.79788907
156Cerebral hypomyelination (HP:0006808)1.77525656
157Polyphagia (HP:0002591)1.77414574
158Median cleft lip (HP:0000161)1.77328720
159Morphological abnormality of the pyramidal tract (HP:0002062)1.77313416
160Long nose (HP:0003189)1.76701653
161Blue irides (HP:0000635)1.76398450
162Congenital sensorineural hearing impairment (HP:0008527)1.75183875
163Abnormality of the septum pellucidum (HP:0007375)1.73887432
164Congenital hepatic fibrosis (HP:0002612)1.73712513
165Abnormal eating behavior (HP:0100738)1.73420976
166Fair hair (HP:0002286)1.73407028
167Gaze-evoked nystagmus (HP:0000640)1.73321978
168Progressive neurologic deterioration (HP:0002344)1.72774971
169Mutism (HP:0002300)1.72623388
170Generalized myoclonic seizures (HP:0002123)1.72586096
171Generalized tonic-clonic seizures (HP:0002069)1.72113319
172Increased neuronal autofluorescent lipopigment (HP:0002074)1.71603458
173Patchy hypopigmentation of hair (HP:0011365)1.71349532
174Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71228196
175Adrenal hypoplasia (HP:0000835)1.70803534
176Diminished movement (HP:0002374)1.70340598
177Stridor (HP:0010307)1.69760887
178Type II lissencephaly (HP:0007260)1.69591377
179Coronal craniosynostosis (HP:0004440)1.69516190
180Bowel incontinence (HP:0002607)1.69413280
181Abnormality of serum amino acid levels (HP:0003112)1.68283165
182Spastic paraplegia (HP:0001258)1.67743062
183Pachygyria (HP:0001302)1.66871538
184Narrow forehead (HP:0000341)1.66496779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.84539323
2STK394.70106584
3OXSR13.76917372
4TRIM283.49937106
5MAP4K23.40567924
6CASK3.03546100
7ACVR1B2.72749818
8PRPF4B2.70378232
9CDK192.68271886
10BCR2.30560101
11STK38L2.22979981
12PBK2.22583305
13ERBB32.22186204
14EPHB12.19630359
15PKN12.07235727
16MST42.05866434
17MAPKAPK52.05649809
18WNK41.98818675
19MET1.93006774
20NTRK11.88584768
21TNIK1.87861521
22FGFR21.84163631
23EPHA41.82118002
24EIF2AK31.79022906
25PINK11.66966448
26NEK61.65959997
27ZAK1.52147858
28WNK11.51540223
29SGK2231.50144556
30SGK4941.50144556
31FGR1.37861891
32MUSK1.32928362
33CSNK1G31.32872606
34LIMK11.32786004
35CSNK1A1L1.30898827
36MAP3K121.24592187
37MARK11.24317245
38PLK31.22624789
39BMPR1B1.21125552
40CAMK2B1.21081659
41CSNK1G21.19791841
42PLK41.18565476
43MAP3K91.16198414
44UHMK11.15720387
45GRK71.13746052
46PAK61.12897933
47STK31.09180507
48MAPK151.08201669
49AKT31.08170301
50ROCK21.05662382
51CSNK1G11.04604734
52INSRR1.04327803
53FER1.02484288
54MKNK21.02416776
55MKNK10.95604273
56PRKCE0.95326845
57CDK50.92746433
58CAMK2D0.92220392
59CAMK2A0.92169256
60GRK10.92012311
61MAP2K70.89105823
62DYRK20.85514173
63BMPR20.85410237
64ARAF0.85187028
65CLK10.84319131
66GRK50.83984219
67SRPK10.83923627
68PHKG10.83209441
69PHKG20.83209441
70ADRBK20.81507778
71NTRK30.80941655
72PAK30.80409553
73MAPK130.79247343
74EPHA30.79145879
75MAP3K130.79110490
76LATS10.78834733
77PRKCQ0.78381545
78PNCK0.78157103
79TRPM70.78125780
80DYRK30.77595110
81TIE10.77512697
82TTK0.77162336
83FES0.76825743
84NTRK20.74608891
85CAMK2G0.70373527
86TSSK60.69618760
87KSR20.68885971
88CDK140.67878333
89RIPK40.67172375
90PRKCH0.66979013
91ICK0.65932195
92CAMKK20.65588476
93MAP3K20.63865857
94MARK20.63546814
95EIF2AK20.61552860
96TAF10.61496739
97MAP2K40.61463561
98PLK10.61373460
99MOS0.61197525
100DAPK20.60845235
101PLK20.60442614
102MAP3K40.60430544
103FYN0.60143744
104NEK10.58581303
105PRKG10.58288997
106BRSK20.55775939
107ITK0.55602964
108MINK10.54232890
109YES10.53907937
110WEE10.52717971
111CDK150.51910011
112ERBB40.51818143
113PTK2B0.50646604
114CDK180.50638053
115PDPK10.48922922
116IRAK20.48900209
117WNK30.48031856
118IRAK10.47895644
119CDK11A0.47348946
120MAPK70.47198417
121TYRO30.46838323
122MAPK120.45625404
123CDK30.45200884
124BCKDK0.43014997
125FLT30.42654946
126RPS6KA40.42557197
127TGFBR10.42023794
128TEC0.42010616
129EGFR0.41942039
130PRKD10.41295279
131HIPK20.41043781
132STK240.40087998
133DYRK1A0.39527013
134PIK3CG0.39455219
135PRKCG0.39057178
136CSNK1A10.39036635
137NEK90.38570608
138PRKACB0.37386463
139ATM0.37097135
140NUAK10.36536711
141PRKACA0.36216721
142SGK10.35931529
143INSR0.35500612
144KSR10.35291236
145ADRBK10.34301704
146CDK60.33993098
147CAMK1G0.33433509
148TXK0.33298267
149VRK10.32451169
150CDC70.32012537
151STK110.30482399
152ABL10.29932088
153ATR0.29691940
154TGFBR20.28064388

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.47159215
2Fatty acid elongation_Homo sapiens_hsa000622.96814750
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.94247425
4Propanoate metabolism_Homo sapiens_hsa006402.92243099
5Ether lipid metabolism_Homo sapiens_hsa005652.57527095
6Non-homologous end-joining_Homo sapiens_hsa034502.39789108
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39466514
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34101232
9Basal transcription factors_Homo sapiens_hsa030222.27670170
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.06601357
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.03282563
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02170208
13Sulfur metabolism_Homo sapiens_hsa009201.89832592
14Homologous recombination_Homo sapiens_hsa034401.77494758
15Fanconi anemia pathway_Homo sapiens_hsa034601.74516980
16Collecting duct acid secretion_Homo sapiens_hsa049661.71375902
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71121075
18Sphingolipid metabolism_Homo sapiens_hsa006001.61685535
19GABAergic synapse_Homo sapiens_hsa047271.57508824
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57181849
21Synaptic vesicle cycle_Homo sapiens_hsa047211.56355525
22Glutamatergic synapse_Homo sapiens_hsa047241.49511531
23beta-Alanine metabolism_Homo sapiens_hsa004101.49130118
24Tryptophan metabolism_Homo sapiens_hsa003801.46476216
25Nicotine addiction_Homo sapiens_hsa050331.45803947
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40498337
27Histidine metabolism_Homo sapiens_hsa003401.38031820
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37309496
29Caffeine metabolism_Homo sapiens_hsa002321.37268801
30Serotonergic synapse_Homo sapiens_hsa047261.36857205
31Morphine addiction_Homo sapiens_hsa050321.34101285
32Rheumatoid arthritis_Homo sapiens_hsa053231.33582420
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.26704390
34Oxidative phosphorylation_Homo sapiens_hsa001901.25843179
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.25621750
36Vibrio cholerae infection_Homo sapiens_hsa051101.24442693
37Axon guidance_Homo sapiens_hsa043601.21637720
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17737706
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16434667
40Protein export_Homo sapiens_hsa030601.16191495
41Linoleic acid metabolism_Homo sapiens_hsa005911.15970684
42Nitrogen metabolism_Homo sapiens_hsa009101.14701974
43Salivary secretion_Homo sapiens_hsa049701.14306508
44Circadian entrainment_Homo sapiens_hsa047131.13509700
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13446982
46Mismatch repair_Homo sapiens_hsa034301.12278676
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09829563
48Butanoate metabolism_Homo sapiens_hsa006501.07550237
49Lysosome_Homo sapiens_hsa041421.06043742
50Long-term depression_Homo sapiens_hsa047301.05685012
51Renin secretion_Homo sapiens_hsa049241.05228497
52Fatty acid degradation_Homo sapiens_hsa000711.03581237
53Cocaine addiction_Homo sapiens_hsa050300.99778761
54RNA degradation_Homo sapiens_hsa030180.96385631
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94674649
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94161612
57Taste transduction_Homo sapiens_hsa047420.93438013
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92619773
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92064977
60Phagosome_Homo sapiens_hsa041450.91169514
61Vitamin B6 metabolism_Homo sapiens_hsa007500.89494111
62Selenocompound metabolism_Homo sapiens_hsa004500.89479957
63Mineral absorption_Homo sapiens_hsa049780.89470012
64Folate biosynthesis_Homo sapiens_hsa007900.87698671
65Insulin secretion_Homo sapiens_hsa049110.85918720
66Gastric acid secretion_Homo sapiens_hsa049710.85911662
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85841435
68Circadian rhythm_Homo sapiens_hsa047100.84608802
69Alzheimers disease_Homo sapiens_hsa050100.84387708
70Amphetamine addiction_Homo sapiens_hsa050310.84181223
71Oocyte meiosis_Homo sapiens_hsa041140.83592942
72Dopaminergic synapse_Homo sapiens_hsa047280.81748400
73Nucleotide excision repair_Homo sapiens_hsa034200.81616713
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78392335
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.77600292
76Cholinergic synapse_Homo sapiens_hsa047250.77128463
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76716491
78Pancreatic secretion_Homo sapiens_hsa049720.74816621
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74673087
80Olfactory transduction_Homo sapiens_hsa047400.73783329
81Ovarian steroidogenesis_Homo sapiens_hsa049130.72926773
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.71611152
83Fatty acid biosynthesis_Homo sapiens_hsa000610.71418302
84Dorso-ventral axis formation_Homo sapiens_hsa043200.70835792
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70529947
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69519886
87Endocytosis_Homo sapiens_hsa041440.67262129
88Arginine and proline metabolism_Homo sapiens_hsa003300.66792418
89Ras signaling pathway_Homo sapiens_hsa040140.66168892
90Phototransduction_Homo sapiens_hsa047440.65661260
91Autoimmune thyroid disease_Homo sapiens_hsa053200.65620828
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.64733518
93Arachidonic acid metabolism_Homo sapiens_hsa005900.63488763
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62983017
95Fatty acid metabolism_Homo sapiens_hsa012120.62092384
96Renal cell carcinoma_Homo sapiens_hsa052110.61393535
97N-Glycan biosynthesis_Homo sapiens_hsa005100.61152127
98Parkinsons disease_Homo sapiens_hsa050120.61028497
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60965838
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58271022
101Vitamin digestion and absorption_Homo sapiens_hsa049770.57847577
102cAMP signaling pathway_Homo sapiens_hsa040240.56761836
103Metabolic pathways_Homo sapiens_hsa011000.54670349
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52962294
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.52898652
106ABC transporters_Homo sapiens_hsa020100.52892207
107African trypanosomiasis_Homo sapiens_hsa051430.52649867
108Calcium signaling pathway_Homo sapiens_hsa040200.52345877
109Peroxisome_Homo sapiens_hsa041460.51798336
110Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51173135
111Long-term potentiation_Homo sapiens_hsa047200.49189807
112Retinol metabolism_Homo sapiens_hsa008300.48967087
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48679742
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48668346
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48592344
116Chemical carcinogenesis_Homo sapiens_hsa052040.47908500
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47624352
118Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47485304
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.47232979
120Malaria_Homo sapiens_hsa051440.45404472
121Regulation of autophagy_Homo sapiens_hsa041400.45032803
122p53 signaling pathway_Homo sapiens_hsa041150.45007205
123Proteasome_Homo sapiens_hsa030500.41468677
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41406767
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41173458
126Glutathione metabolism_Homo sapiens_hsa004800.40761052
127Glycerolipid metabolism_Homo sapiens_hsa005610.40460965
128Chemokine signaling pathway_Homo sapiens_hsa040620.40377257
129ErbB signaling pathway_Homo sapiens_hsa040120.39967248
130Choline metabolism in cancer_Homo sapiens_hsa052310.39765162
131Prion diseases_Homo sapiens_hsa050200.39597984
132Cardiac muscle contraction_Homo sapiens_hsa042600.39525657
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39246720
134Starch and sucrose metabolism_Homo sapiens_hsa005000.38676759
135TGF-beta signaling pathway_Homo sapiens_hsa043500.36402421
136One carbon pool by folate_Homo sapiens_hsa006700.35427219
137Cell cycle_Homo sapiens_hsa041100.33881660
138RNA transport_Homo sapiens_hsa030130.27943666
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26948511
140Purine metabolism_Homo sapiens_hsa002300.23047105

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